BindingDB logo
myBDB logout

PubMed code 26757340

Compile data set for download or QSAR
Found 34 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Quinolone resistance protein NorA


(Staphylococcus aureus)		BDBM50153269
PNG
(CHEMBL3775575)
Show SMILES CCOC(=O)c1c(C)n(Cc2cccc(c2)[N+]([O-])=O)c2ccc(OCCCN3CCCCC3)cc12
Show InChI InChI=1S/C27H33N3O5/c1-3-34-27(31)26-20(2)29(19-21-9-7-10-22(17-21)30(32)33)25-12-11-23(18-24(25)26)35-16-8-15-28-13-5-4-6-14-28/h7,9-12,17-18H,3-6,8,13-16,19H2,1-2H3
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 4.40E+3n/an/an/an/an/an/a



University of Perugia

Curated by ChEMBL


Assay Description
Inhibition of NorA efflux pump in Staphylococcus aureus 1199B assessed as reduction in EtBr efflux incubated for 20 mins measured for 5 mins by real-...

J Med Chem 59: 867-91 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01219
BindingDB Entry DOI: 10.7270/Q28W3G57
More data for this
Ligand-Target Pair
Quinolone resistance protein NorA


(Staphylococcus aureus)		BDBM50153186
PNG
(CHEMBL3774520)
Show SMILES CCOC(=O)c1c(C)n(Cc2ccccc2F)c2ccc(OCCCN3CCCCC3)cc12
Show InChI InChI=1S/C27H33FN2O3/c1-3-32-27(31)26-20(2)30(19-21-10-5-6-11-24(21)28)25-13-12-22(18-23(25)26)33-17-9-16-29-14-7-4-8-15-29/h5-6,10-13,18H,3-4,7-9,14-17,19H2,1-2H3
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 4.80E+3n/an/an/an/an/an/a



University of Perugia

Curated by ChEMBL


Assay Description
Inhibition of NorA efflux pump in Staphylococcus aureus 1199B assessed as reduction in EtBr efflux incubated for 20 mins measured for 5 mins by real-...

J Med Chem 59: 867-91 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01219
BindingDB Entry DOI: 10.7270/Q28W3G57
More data for this
Ligand-Target Pair
Quinolone resistance protein NorA


(Staphylococcus aureus)		BDBM50153316
PNG
(CHEMBL3775207)
Show SMILES CCOC(=O)c1c(C)n(Cc2ccccc2C)c2ccc(OCCCN3CCCCC3)cc12
Show InChI InChI=1S/C28H36N2O3/c1-4-32-28(31)27-22(3)30(20-23-12-7-6-11-21(23)2)26-14-13-24(19-25(26)27)33-18-10-17-29-15-8-5-9-16-29/h6-7,11-14,19H,4-5,8-10,15-18,20H2,1-3H3
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 4.80E+3n/an/an/an/an/an/a



University of Perugia

Curated by ChEMBL


Assay Description
Inhibition of NorA efflux pump in Staphylococcus aureus 1199B assessed as reduction in EtBr efflux incubated for 20 mins measured for 5 mins by real-...

J Med Chem 59: 867-91 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01219
BindingDB Entry DOI: 10.7270/Q28W3G57
More data for this
Ligand-Target Pair
Quinolone resistance protein NorA


(Staphylococcus aureus)		BDBM50153183
PNG
(CHEMBL3774548)
Show SMILES CCOC(=O)c1c(C)n(Cc2ccccc2OC)c2ccc(OCCCN3CCCCC3)cc12
Show InChI InChI=1S/C28H36N2O4/c1-4-33-28(31)27-21(2)30(20-22-11-6-7-12-26(22)32-3)25-14-13-23(19-24(25)27)34-18-10-17-29-15-8-5-9-16-29/h6-7,11-14,19H,4-5,8-10,15-18,20H2,1-3H3
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 5.00E+3n/an/an/an/an/an/a



University of Perugia

Curated by ChEMBL


Assay Description
Inhibition of NorA efflux pump in Staphylococcus aureus 1199B assessed as reduction in EtBr efflux incubated for 20 mins measured for 5 mins by real-...

J Med Chem 59: 867-91 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01219
BindingDB Entry DOI: 10.7270/Q28W3G57
More data for this
Ligand-Target Pair
Quinolone resistance protein NorA


(Staphylococcus aureus)		BDBM50153314
PNG
(CHEMBL3774689)
Show SMILES CCOC(=O)c1c(C)n(Cc2ccccc2)c2ccc(OCC(F)CN3CCCCC3)cc12
Show InChI InChI=1S/C27H33FN2O3/c1-3-32-27(31)26-20(2)30(17-21-10-6-4-7-11-21)25-13-12-23(16-24(25)26)33-19-22(28)18-29-14-8-5-9-15-29/h4,6-7,10-13,16,22H,3,5,8-9,14-15,17-19H2,1-2H3
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 5.10E+3n/an/an/an/an/an/a



University of Perugia

Curated by ChEMBL


Assay Description
Inhibition of NorA efflux pump in Staphylococcus aureus 1199B assessed as reduction in EtBr efflux incubated for 20 mins measured for 5 mins by real-...

J Med Chem 59: 867-91 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01219
BindingDB Entry DOI: 10.7270/Q28W3G57
More data for this
Ligand-Target Pair
Quinolone resistance protein NorA


(Staphylococcus aureus)		BDBM50153284
PNG
(CHEMBL3775852)
Show SMILES CCOC(=O)c1c(C)n(Cc2ccccc2)c2ccc(OCC(O)CN3CCCCC3)cc12
Show InChI InChI=1S/C27H34N2O4/c1-3-32-27(31)26-20(2)29(17-21-10-6-4-7-11-21)25-13-12-23(16-24(25)26)33-19-22(30)18-28-14-8-5-9-15-28/h4,6-7,10-13,16,22,30H,3,5,8-9,14-15,17-19H2,1-2H3
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 5.80E+3n/an/an/an/an/an/a



University of Perugia

Curated by ChEMBL


Assay Description
Inhibition of NorA efflux pump in Staphylococcus aureus 1199B assessed as reduction in EtBr efflux incubated for 20 mins measured for 5 mins by real-...

J Med Chem 59: 867-91 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01219
BindingDB Entry DOI: 10.7270/Q28W3G57
More data for this
Ligand-Target Pair
Quinolone resistance protein NorA


(Staphylococcus aureus)		BDBM50153278
PNG
(CHEMBL3775105)
Show SMILES CCOC(=O)c1c(C)n(Cc2ccccc2)c2ccc(OCCCN3CCCCC3)cc12
Show InChI InChI=1S/C27H34N2O3/c1-3-31-27(30)26-21(2)29(20-22-11-6-4-7-12-22)25-14-13-23(19-24(25)26)32-18-10-17-28-15-8-5-9-16-28/h4,6-7,11-14,19H,3,5,8-10,15-18,20H2,1-2H3
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 6.00E+3n/an/an/an/an/an/a



University of Perugia

Curated by ChEMBL


Assay Description
Inhibition of NorA efflux pump in Staphylococcus aureus 1199B assessed as reduction in EtBr efflux incubated for 20 mins measured for 5 mins by real-...

J Med Chem 59: 867-91 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01219
BindingDB Entry DOI: 10.7270/Q28W3G57
More data for this
Ligand-Target Pair
Quinolone resistance protein NorA


(Staphylococcus aureus)		BDBM50153317
PNG
(CHEMBL3774886)
Show SMILES CCOC(=O)c1c(C)n(Cc2cccc(C)c2)c2ccc(OCCCN3CCCCC3)cc12
Show InChI InChI=1S/C28H36N2O3/c1-4-32-28(31)27-22(3)30(20-23-11-8-10-21(2)18-23)26-13-12-24(19-25(26)27)33-17-9-16-29-14-6-5-7-15-29/h8,10-13,18-19H,4-7,9,14-17,20H2,1-3H3
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 6.10E+3n/an/an/an/an/an/a



University of Perugia

Curated by ChEMBL


Assay Description
Inhibition of NorA efflux pump in Staphylococcus aureus 1199B assessed as reduction in EtBr efflux incubated for 20 mins measured for 5 mins by real-...

J Med Chem 59: 867-91 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01219
BindingDB Entry DOI: 10.7270/Q28W3G57
More data for this
Ligand-Target Pair
Quinolone resistance protein NorA


(Staphylococcus aureus)		BDBM50153187
PNG
(CHEMBL3775401)
Show SMILES CCOC(=O)c1c(C)n(Cc2cccc(F)c2)c2ccc(OCCCN3CCCCC3)cc12
Show InChI InChI=1S/C27H33FN2O3/c1-3-32-27(31)26-20(2)30(19-21-9-7-10-22(28)17-21)25-12-11-23(18-24(25)26)33-16-8-15-29-13-5-4-6-14-29/h7,9-12,17-18H,3-6,8,13-16,19H2,1-2H3
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 6.10E+3n/an/an/an/an/an/a



University of Perugia

Curated by ChEMBL


Assay Description
Inhibition of NorA efflux pump in Staphylococcus aureus 1199B assessed as reduction in EtBr efflux incubated for 20 mins measured for 5 mins by real-...

J Med Chem 59: 867-91 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01219
BindingDB Entry DOI: 10.7270/Q28W3G57
More data for this
Ligand-Target Pair
Quinolone resistance protein NorA


(Staphylococcus aureus)		BDBM50153271
PNG
(CHEMBL3774968)
Show SMILES CCOC(=O)Cc1c(C)n(Cc2ccccc2)c2ccc(OCCCN3CCCCCC3)cc12
Show InChI InChI=1S/C29H38N2O3/c1-3-33-29(32)21-26-23(2)31(22-24-12-7-6-8-13-24)28-15-14-25(20-27(26)28)34-19-11-18-30-16-9-4-5-10-17-30/h6-8,12-15,20H,3-5,9-11,16-19,21-22H2,1-2H3
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 6.10E+3n/an/an/an/an/an/a



University of Perugia

Curated by ChEMBL


Assay Description
Inhibition of NorA efflux pump in Staphylococcus aureus 1199B assessed as reduction in EtBr efflux incubated for 20 mins measured for 5 mins by real-...

J Med Chem 59: 867-91 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01219
BindingDB Entry DOI: 10.7270/Q28W3G57
More data for this
Ligand-Target Pair
Quinolone resistance protein NorA


(Staphylococcus aureus)		BDBM50153268
PNG
(CHEMBL3775173)
Show SMILES CCOC(=O)c1c(C)n(Cc2ccccc2[N+]([O-])=O)c2ccc(OCCCN3CCCCC3)cc12
Show InChI InChI=1S/C27H33N3O5/c1-3-34-27(31)26-20(2)29(19-21-10-5-6-11-24(21)30(32)33)25-13-12-22(18-23(25)26)35-17-9-16-28-14-7-4-8-15-28/h5-6,10-13,18H,3-4,7-9,14-17,19H2,1-2H3
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 6.30E+3n/an/an/an/an/an/a



University of Perugia

Curated by ChEMBL


Assay Description
Inhibition of NorA efflux pump in Staphylococcus aureus 1199B assessed as reduction in EtBr efflux incubated for 20 mins measured for 5 mins by real-...

J Med Chem 59: 867-91 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01219
BindingDB Entry DOI: 10.7270/Q28W3G57
More data for this
Ligand-Target Pair
Quinolone resistance protein NorA


(Staphylococcus aureus)		BDBM50153270
PNG
(CHEMBL3775819)
Show SMILES CCOC(=O)c1c(C)n(Cc2ccc(cc2)[N+]([O-])=O)c2ccc(OCCCN3CCCCC3)cc12
Show InChI InChI=1S/C27H33N3O5/c1-3-34-27(31)26-20(2)29(19-21-8-10-22(11-9-21)30(32)33)25-13-12-23(18-24(25)26)35-17-7-16-28-14-5-4-6-15-28/h8-13,18H,3-7,14-17,19H2,1-2H3
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 6.50E+3n/an/an/an/an/an/a



University of Perugia

Curated by ChEMBL


Assay Description
Inhibition of NorA efflux pump in Staphylococcus aureus 1199B assessed as reduction in EtBr efflux incubated for 20 mins measured for 5 mins by real-...

J Med Chem 59: 867-91 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01219
BindingDB Entry DOI: 10.7270/Q28W3G57
More data for this
Ligand-Target Pair
Quinolone resistance protein NorA


(Staphylococcus aureus)		BDBM50153272
PNG
(CHEMBL3775722)
Show SMILES Cc1cc2cc(OCCCN3CCCCC3)ccc2n1Cc1ccccc1
Show InChI InChI=1S/C24H30N2O/c1-20-17-22-18-23(27-16-8-15-25-13-6-3-7-14-25)11-12-24(22)26(20)19-21-9-4-2-5-10-21/h2,4-5,9-12,17-18H,3,6-8,13-16,19H2,1H3
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 6.60E+3n/an/an/an/an/an/a



University of Perugia

Curated by ChEMBL


Assay Description
Inhibition of NorA efflux pump in Staphylococcus aureus 1199B assessed as reduction in EtBr efflux incubated for 20 mins measured for 5 mins by real-...

J Med Chem 59: 867-91 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01219
BindingDB Entry DOI: 10.7270/Q28W3G57
More data for this
Ligand-Target Pair
Quinolone resistance protein NorA


(Staphylococcus aureus)		BDBM50153182
PNG
(CHEMBL3775053)
Show SMILES CCOC(=O)c1c(C)n(Cc2ccc(C)cc2)c2ccc(OCCCN3CCCCC3)cc12
Show InChI InChI=1S/C28H36N2O3/c1-4-32-28(31)27-22(3)30(20-23-11-9-21(2)10-12-23)26-14-13-24(19-25(26)27)33-18-8-17-29-15-6-5-7-16-29/h9-14,19H,4-8,15-18,20H2,1-3H3
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 6.70E+3n/an/an/an/an/an/a



University of Perugia

Curated by ChEMBL


Assay Description
Inhibition of NorA efflux pump in Staphylococcus aureus 1199B assessed as reduction in EtBr efflux incubated for 20 mins measured for 5 mins by real-...

J Med Chem 59: 867-91 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01219
BindingDB Entry DOI: 10.7270/Q28W3G57
More data for this
Ligand-Target Pair
Quinolone resistance protein NorA


(Staphylococcus aureus)		BDBM50153283
PNG
(CHEMBL3774445)
Show SMILES CCOC(=O)c1c(C)n(Cc2ccccc2)c2ccc(OCCCCN)cc12
Show InChI InChI=1S/C23H28N2O3/c1-3-27-23(26)22-17(2)25(16-18-9-5-4-6-10-18)21-12-11-19(15-20(21)22)28-14-8-7-13-24/h4-6,9-12,15H,3,7-8,13-14,16,24H2,1-2H3
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 6.70E+3n/an/an/an/an/an/a



University of Perugia

Curated by ChEMBL


Assay Description
Inhibition of NorA efflux pump in Staphylococcus aureus 1199B assessed as reduction in EtBr efflux incubated for 20 mins measured for 5 mins by real-...

J Med Chem 59: 867-91 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01219
BindingDB Entry DOI: 10.7270/Q28W3G57
More data for this
Ligand-Target Pair
Quinolone resistance protein NorA


(Staphylococcus aureus)		BDBM50153285
PNG
(CHEMBL3774995)
Show SMILES CCOC(=O)c1c(C)n(Cc2ccccc2)c2ccc(OCC(O)CN3CCCCCC3)cc12
Show InChI InChI=1S/C28H36N2O4/c1-3-33-28(32)27-21(2)30(18-22-11-7-6-8-12-22)26-14-13-24(17-25(26)27)34-20-23(31)19-29-15-9-4-5-10-16-29/h6-8,11-14,17,23,31H,3-5,9-10,15-16,18-20H2,1-2H3
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 6.80E+3n/an/an/an/an/an/a



University of Perugia

Curated by ChEMBL


Assay Description
Inhibition of NorA efflux pump in Staphylococcus aureus 1199B assessed as reduction in EtBr efflux incubated for 20 mins measured for 5 mins by real-...

J Med Chem 59: 867-91 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01219
BindingDB Entry DOI: 10.7270/Q28W3G57
More data for this
Ligand-Target Pair
Quinolone resistance protein NorA


(Staphylococcus aureus)		BDBM50153185
PNG
(CHEMBL3775726)
Show SMILES CCOC(=O)c1c(C)n(Cc2ccc(OC)cc2)c2ccc(OCCCN3CCCCC3)cc12
Show InChI InChI=1S/C28H36N2O4/c1-4-33-28(31)27-21(2)30(20-22-9-11-23(32-3)12-10-22)26-14-13-24(19-25(26)27)34-18-8-17-29-15-6-5-7-16-29/h9-14,19H,4-8,15-18,20H2,1-3H3
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 7.10E+3n/an/an/an/an/an/a



University of Perugia

Curated by ChEMBL


Assay Description
Inhibition of NorA efflux pump in Staphylococcus aureus 1199B assessed as reduction in EtBr efflux incubated for 20 mins measured for 5 mins by real-...

J Med Chem 59: 867-91 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01219
BindingDB Entry DOI: 10.7270/Q28W3G57
More data for this
Ligand-Target Pair
Quinolone resistance protein NorA


(Staphylococcus aureus)		BDBM50153184
PNG
(CHEMBL3774891)
Show SMILES CCOC(=O)c1c(C)n(Cc2cccc(OC)c2)c2ccc(OCCCN3CCCCC3)cc12
Show InChI InChI=1S/C28H36N2O4/c1-4-33-28(31)27-21(2)30(20-22-10-8-11-23(18-22)32-3)26-13-12-24(19-25(26)27)34-17-9-16-29-14-6-5-7-15-29/h8,10-13,18-19H,4-7,9,14-17,20H2,1-3H3
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 7.30E+3n/an/an/an/an/an/a



University of Perugia

Curated by ChEMBL


Assay Description
Inhibition of NorA efflux pump in Staphylococcus aureus 1199B assessed as reduction in EtBr efflux incubated for 20 mins measured for 5 mins by real-...

J Med Chem 59: 867-91 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01219
BindingDB Entry DOI: 10.7270/Q28W3G57
More data for this
Ligand-Target Pair
Quinolone resistance protein NorA


(Staphylococcus aureus)		BDBM50153192
PNG
(CHEMBL3775789)
Show SMILES CCOC(=O)c1c(C)n(Cc2ccc(F)cc2)c2ccc(OCCCN3CCCCC3)cc12
Show InChI InChI=1S/C27H33FN2O3/c1-3-32-27(31)26-20(2)30(19-21-8-10-22(28)11-9-21)25-13-12-23(18-24(25)26)33-17-7-16-29-14-5-4-6-15-29/h8-13,18H,3-7,14-17,19H2,1-2H3
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 8.70E+3n/an/an/an/an/an/a



University of Perugia

Curated by ChEMBL


Assay Description
Inhibition of NorA efflux pump in Staphylococcus aureus 1199B assessed as reduction in EtBr efflux incubated for 20 mins measured for 5 mins by real-...

J Med Chem 59: 867-91 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01219
BindingDB Entry DOI: 10.7270/Q28W3G57
More data for this
Ligand-Target Pair
Quinolone resistance protein NorA


(Staphylococcus aureus)		BDBM50153277
PNG
(CHEMBL3774527)
Show SMILES CCOC(=O)c1c(C)n(Cc2ccccc2)c2ccc(OCCN3CCN(C)CC3)cc12
Show InChI InChI=1S/C26H33N3O3/c1-4-31-26(30)25-20(2)29(19-21-8-6-5-7-9-21)24-11-10-22(18-23(24)25)32-17-16-28-14-12-27(3)13-15-28/h5-11,18H,4,12-17,19H2,1-3H3
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 1.01E+4n/an/an/an/an/an/a



University of Perugia

Curated by ChEMBL


Assay Description
Inhibition of NorA efflux pump in Staphylococcus aureus 1199B assessed as reduction in EtBr efflux incubated for 20 mins measured for 5 mins by real-...

J Med Chem 59: 867-91 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01219
BindingDB Entry DOI: 10.7270/Q28W3G57
More data for this
Ligand-Target Pair
Quinolone resistance protein NorA


(Staphylococcus aureus)		BDBM50153288
PNG
(CHEMBL3775693)
Show SMILES CCOC(=O)c1c(C)n(Cc2ccccc2)c2ccc(OCC(N)CO)cc12
Show InChI InChI=1S/C22H26N2O4/c1-3-27-22(26)21-15(2)24(12-16-7-5-4-6-8-16)20-10-9-18(11-19(20)21)28-14-17(23)13-25/h4-11,17,25H,3,12-14,23H2,1-2H3
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 1.04E+4n/an/an/an/an/an/a



University of Perugia

Curated by ChEMBL


Assay Description
Inhibition of NorA efflux pump in Staphylococcus aureus 1199B assessed as reduction in EtBr efflux incubated for 20 mins measured for 5 mins by real-...

J Med Chem 59: 867-91 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01219
BindingDB Entry DOI: 10.7270/Q28W3G57
More data for this
Ligand-Target Pair
Quinolone resistance protein NorA


(Staphylococcus aureus)		BDBM50153279
PNG
(CHEMBL3775483)
Show SMILES CCOC(=O)c1c(C)n(Cc2ccccc2)c2ccc(OCCCN3CCOCC3)cc12
Show InChI InChI=1S/C26H32N2O4/c1-3-31-26(29)25-20(2)28(19-21-8-5-4-6-9-21)24-11-10-22(18-23(24)25)32-15-7-12-27-13-16-30-17-14-27/h4-6,8-11,18H,3,7,12-17,19H2,1-2H3
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents
Article
PubMed
n/an/a 1.06E+4n/an/an/an/an/an/a



University of Perugia

Curated by ChEMBL


Assay Description
Inhibition of NorA efflux pump in Staphylococcus aureus 1199B assessed as reduction in EtBr efflux incubated for 20 mins measured for 5 mins by real-...

J Med Chem 59: 867-91 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01219
BindingDB Entry DOI: 10.7270/Q28W3G57
More data for this
Ligand-Target Pair
Quinolone resistance protein NorA


(Staphylococcus aureus)		BDBM50153274
PNG
(CHEMBL3775322)
Show SMILES CCOC(=O)c1c(C)n(Cc2ccccc2)c2ccc(OCCN3CCCCC3)cc12
Show InChI InChI=1S/C26H32N2O3/c1-3-30-26(29)25-20(2)28(19-21-10-6-4-7-11-21)24-13-12-22(18-23(24)25)31-17-16-27-14-8-5-9-15-27/h4,6-7,10-13,18H,3,5,8-9,14-17,19H2,1-2H3
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 1.16E+4n/an/an/an/an/an/a



University of Perugia

Curated by ChEMBL


Assay Description
Inhibition of NorA efflux pump in Staphylococcus aureus 1199B assessed as reduction in EtBr efflux incubated for 20 mins measured for 5 mins by real-...

J Med Chem 59: 867-91 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01219
BindingDB Entry DOI: 10.7270/Q28W3G57
More data for this
Ligand-Target Pair
Quinolone resistance protein NorA


(Staphylococcus aureus)		BDBM50153280
PNG
(CHEMBL3774675)
Show SMILES CCOC(=O)c1c(C)n(Cc2ccccc2)c2ccc(OCCCN3CCN(C)CC3)cc12
Show InChI InChI=1S/C27H35N3O3/c1-4-32-27(31)26-21(2)30(20-22-9-6-5-7-10-22)25-12-11-23(19-24(25)26)33-18-8-13-29-16-14-28(3)15-17-29/h5-7,9-12,19H,4,8,13-18,20H2,1-3H3
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 1.19E+4n/an/an/an/an/an/a



University of Perugia

Curated by ChEMBL


Assay Description
Inhibition of NorA efflux pump in Staphylococcus aureus 1199B assessed as reduction in EtBr efflux incubated for 20 mins measured for 5 mins by real-...

J Med Chem 59: 867-91 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01219
BindingDB Entry DOI: 10.7270/Q28W3G57
More data for this
Ligand-Target Pair
Quinolone resistance protein NorA


(Staphylococcus aureus)		BDBM50153282
PNG
(CHEMBL3775841)
Show SMILES CCOC(=O)c1c(C)n(Cc2ccccc2)c2ccc(OCCCN)cc12
Show InChI InChI=1S/C22H26N2O3/c1-3-26-22(25)21-16(2)24(15-17-8-5-4-6-9-17)20-11-10-18(14-19(20)21)27-13-7-12-23/h4-6,8-11,14H,3,7,12-13,15,23H2,1-2H3
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 1.25E+4n/an/an/an/an/an/a



University of Perugia

Curated by ChEMBL


Assay Description
Inhibition of NorA efflux pump in Staphylococcus aureus 1199B assessed as reduction in EtBr efflux incubated for 20 mins measured for 5 mins by real-...

J Med Chem 59: 867-91 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01219
BindingDB Entry DOI: 10.7270/Q28W3G57
More data for this
Ligand-Target Pair
Quinolone resistance protein NorA


(Staphylococcus aureus)		BDBM50153281
PNG
(CHEMBL3775062)
Show SMILES CCOC(=O)c1c(C)n(Cc2ccccc2)c2ccc(OCCCN3CCNCC3)cc12
Show InChI InChI=1S/C26H33N3O3/c1-3-31-26(30)25-20(2)29(19-21-8-5-4-6-9-21)24-11-10-22(18-23(24)25)32-17-7-14-28-15-12-27-13-16-28/h4-6,8-11,18,27H,3,7,12-17,19H2,1-2H3
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 1.25E+4n/an/an/an/an/an/a



University of Perugia

Curated by ChEMBL


Assay Description
Inhibition of NorA efflux pump in Staphylococcus aureus 1199B assessed as reduction in EtBr efflux incubated for 20 mins measured for 5 mins by real-...

J Med Chem 59: 867-91 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01219
BindingDB Entry DOI: 10.7270/Q28W3G57
More data for this
Ligand-Target Pair
Quinolone resistance protein NorA


(Staphylococcus aureus)		BDBM50153315
PNG
(CHEMBL3774582)
Show SMILES CCOC(=O)c1c(C)n(CCc2ccccc2)c2ccc(OCCCN3CCCCC3)cc12
Show InChI InChI=1S/C28H36N2O3/c1-3-32-28(31)27-22(2)30(19-15-23-11-6-4-7-12-23)26-14-13-24(21-25(26)27)33-20-10-18-29-16-8-5-9-17-29/h4,6-7,11-14,21H,3,5,8-10,15-20H2,1-2H3
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.37E+4n/an/an/an/an/an/a



University of Perugia

Curated by ChEMBL


Assay Description
Inhibition of NorA efflux pump in Staphylococcus aureus 1199B assessed as reduction in EtBr efflux incubated for 20 mins measured for 5 mins by real-...

J Med Chem 59: 867-91 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01219
BindingDB Entry DOI: 10.7270/Q28W3G57
More data for this
Ligand-Target Pair
Quinolone resistance protein NorA


(Staphylococcus aureus)		BDBM50153249
PNG
(CHEMBL3775871)
Show SMILES CCOC(=O)c1c(C)n(Cc2ccc(cc2)C(F)(F)F)c2ccc(OCCCN3CCCCC3)cc12
Show InChI InChI=1S/C28H33F3N2O3/c1-3-35-27(34)26-20(2)33(19-21-8-10-22(11-9-21)28(29,30)31)25-13-12-23(18-24(25)26)36-17-7-16-32-14-5-4-6-15-32/h8-13,18H,3-7,14-17,19H2,1-2H3
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 1.41E+4n/an/an/an/an/an/a



University of Perugia

Curated by ChEMBL


Assay Description
Inhibition of NorA efflux pump in Staphylococcus aureus 1199B assessed as reduction in EtBr efflux incubated for 20 mins measured for 5 mins by real-...

J Med Chem 59: 867-91 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01219
BindingDB Entry DOI: 10.7270/Q28W3G57
More data for this
Ligand-Target Pair
Quinolone resistance protein NorA


(Staphylococcus aureus)		BDBM50153247
PNG
(CHEMBL3775857)
Show SMILES CCOC(=O)c1c(C)n(Cc2cccc(c2)C(F)(F)F)c2ccc(OCCCN3CCCCC3)cc12
Show InChI InChI=1S/C28H33F3N2O3/c1-3-35-27(34)26-20(2)33(19-21-9-7-10-22(17-21)28(29,30)31)25-12-11-23(18-24(25)26)36-16-8-15-32-13-5-4-6-14-32/h7,9-12,17-18H,3-6,8,13-16,19H2,1-2H3
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 1.42E+4n/an/an/an/an/an/a



University of Perugia

Curated by ChEMBL


Assay Description
Inhibition of NorA efflux pump in Staphylococcus aureus 1199B assessed as reduction in EtBr efflux incubated for 20 mins measured for 5 mins by real-...

J Med Chem 59: 867-91 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01219
BindingDB Entry DOI: 10.7270/Q28W3G57
More data for this
Ligand-Target Pair
Quinolone resistance protein NorA


(Staphylococcus aureus)		BDBM50153276
PNG
(CHEMBL3775445)
Show SMILES CCOC(=O)c1c(C)n(Cc2ccccc2)c2ccc(OCCN3CCNCC3)cc12
Show InChI InChI=1S/C25H31N3O3/c1-3-30-25(29)24-19(2)28(18-20-7-5-4-6-8-20)23-10-9-21(17-22(23)24)31-16-15-27-13-11-26-12-14-27/h4-10,17,26H,3,11-16,18H2,1-2H3
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 1.55E+4n/an/an/an/an/an/a



University of Perugia

Curated by ChEMBL


Assay Description
Inhibition of NorA efflux pump in Staphylococcus aureus 1199B assessed as reduction in EtBr efflux incubated for 20 mins measured for 5 mins by real-...

J Med Chem 59: 867-91 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01219
BindingDB Entry DOI: 10.7270/Q28W3G57
More data for this
Ligand-Target Pair
Quinolone resistance protein NorA


(Staphylococcus aureus)		BDBM50153275
PNG
(CHEMBL3775842)
Show SMILES CCOC(=O)c1c(C)n(Cc2ccccc2)c2ccc(OCCN3CCOCC3)cc12
Show InChI InChI=1S/C25H30N2O4/c1-3-30-25(28)24-19(2)27(18-20-7-5-4-6-8-20)23-10-9-21(17-22(23)24)31-16-13-26-11-14-29-15-12-26/h4-10,17H,3,11-16,18H2,1-2H3
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 1.68E+4n/an/an/an/an/an/a



University of Perugia

Curated by ChEMBL


Assay Description
Inhibition of NorA efflux pump in Staphylococcus aureus 1199B assessed as reduction in EtBr efflux incubated for 20 mins measured for 5 mins by real-...

J Med Chem 59: 867-91 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01219
BindingDB Entry DOI: 10.7270/Q28W3G57
More data for this
Ligand-Target Pair
Quinolone resistance protein NorA


(Staphylococcus aureus)		BDBM50153286
PNG
(CHEMBL3775271)
Show SMILES CCOC(=O)c1c(C)n(Cc2ccccc2)c2ccc(OCC(O)CN3CCOCC3)cc12
Show InChI InChI=1S/C26H32N2O5/c1-3-32-26(30)25-19(2)28(16-20-7-5-4-6-8-20)24-10-9-22(15-23(24)25)33-18-21(29)17-27-11-13-31-14-12-27/h4-10,15,21,29H,3,11-14,16-18H2,1-2H3
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 1.70E+4n/an/an/an/an/an/a



University of Perugia

Curated by ChEMBL


Assay Description
Inhibition of NorA efflux pump in Staphylococcus aureus 1199B assessed as reduction in EtBr efflux incubated for 20 mins measured for 5 mins by real-...

J Med Chem 59: 867-91 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01219
BindingDB Entry DOI: 10.7270/Q28W3G57
More data for this
Ligand-Target Pair
Quinolone resistance protein NorA


(Staphylococcus aureus)		BDBM50153287
PNG
(CHEMBL3775507)
Show SMILES CCOC(=O)c1c(C)n(Cc2ccccc2)c2ccc(OCC(O)CN)cc12
Show InChI InChI=1S/C22H26N2O4/c1-3-27-22(26)21-15(2)24(13-16-7-5-4-6-8-16)20-10-9-18(11-19(20)21)28-14-17(25)12-23/h4-11,17,25H,3,12-14,23H2,1-2H3
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 1.71E+4n/an/an/an/an/an/a



University of Perugia

Curated by ChEMBL


Assay Description
Inhibition of NorA efflux pump in Staphylococcus aureus 1199B assessed as reduction in EtBr efflux incubated for 20 mins measured for 5 mins by real-...

J Med Chem 59: 867-91 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01219
BindingDB Entry DOI: 10.7270/Q28W3G57
More data for this
Ligand-Target Pair
Quinolone resistance protein NorA


(Staphylococcus aureus)		BDBM50153273
PNG
(CHEMBL3775114)
Show SMILES CCOC(=O)c1c(C)n(Cc2ccccc2)c2ccc(OCCN(C)C)cc12
Show InChI InChI=1S/C23H28N2O3/c1-5-27-23(26)22-17(2)25(16-18-9-7-6-8-10-18)21-12-11-19(15-20(21)22)28-14-13-24(3)4/h6-12,15H,5,13-14,16H2,1-4H3
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 2.25E+4n/an/an/an/an/an/a



University of Perugia

Curated by ChEMBL


Assay Description
Inhibition of NorA efflux pump in Staphylococcus aureus 1199B assessed as reduction in EtBr efflux incubated for 20 mins measured for 5 mins by real-...

J Med Chem 59: 867-91 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01219
BindingDB Entry DOI: 10.7270/Q28W3G57
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%