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PubMed code 9685232

Compile data set for download or QSAR
Found 26 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Glycogen phosphorylase, liver form


(Homo sapiens (Human))		BDBM50065954
PNG
((S)-5-chloro-N-(1-(dimethylamino)-1-oxo-3-phenylpr...)
Show SMILES CN(C)C(=O)[C@H](Cc1ccccc1)NC(=O)c1cc2cc(Cl)ccc2[nH]1
Show InChI InChI=1S/C20H20ClN3O2/c1-24(2)20(26)18(10-13-6-4-3-5-7-13)23-19(25)17-12-14-11-15(21)8-9-16(14)22-17/h3-9,11-12,18,22H,10H2,1-2H3,(H,23,25)/t18-/m0/s1
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n/an/a 82n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against recombinant human liver glycogen phosphorylase a (rHLGPa) catalyzed release of phosphate from glucose-1-phosphat...

J Med Chem 41: 2934-8 (1998)


Article DOI: 10.1021/jm980264k
BindingDB Entry DOI: 10.7270/Q2NS0T1T
More data for this
Ligand-Target Pair
Glycogen phosphorylase, liver form


(Homo sapiens (Human))		BDBM50065955
PNG
(5-Bromo-1H-indole-2-carboxylic acid ((1S,2R)-1-ben...)
Show SMILES CN(C)C(=O)[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cc2cc(Br)ccc2[nH]1
Show InChI InChI=1S/C21H22BrN3O3/c1-25(2)21(28)19(26)17(10-13-6-4-3-5-7-13)24-20(27)18-12-14-11-15(22)8-9-16(14)23-18/h3-9,11-12,17,19,23,26H,10H2,1-2H3,(H,24,27)/t17-,19+/m0/s1
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n/an/a 97n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against recombinant human liver glycogen phosphorylase a (rHLGPa) catalyzed release of phosphate from glucose-1-phosphat...

J Med Chem 41: 2934-8 (1998)


Article DOI: 10.1021/jm980264k
BindingDB Entry DOI: 10.7270/Q2NS0T1T
More data for this
Ligand-Target Pair
Glycogen phosphorylase, liver form


(Homo sapiens (Human))		BDBM50065944
PNG
(5-Bromo-1H-indole-2-carboxylic acid ((S)-1-dimethy...)
Show SMILES CN(C)C(=O)[C@H](Cc1ccccc1)NC(=O)c1cc2cc(Br)ccc2[nH]1
Show InChI InChI=1S/C20H20BrN3O2/c1-24(2)20(26)18(10-13-6-4-3-5-7-13)23-19(25)17-12-14-11-15(21)8-9-16(14)22-17/h3-9,11-12,18,22H,10H2,1-2H3,(H,23,25)/t18-/m0/s1
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n/an/a 110n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against recombinant human liver glycogen phosphorylase a (rHLGPa) catalyzed release of phosphate from glucose-1-phosphat...

J Med Chem 41: 2934-8 (1998)


Article DOI: 10.1021/jm980264k
BindingDB Entry DOI: 10.7270/Q2NS0T1T
More data for this
Ligand-Target Pair
Glycogen phosphorylase, liver form


(Homo sapiens (Human))		BDBM50065951
PNG
(5-Chloro-1H-indole-2-carboxylic acid ((S)-1-methyl...)
Show SMILES CNC(=O)[C@H](Cc1ccccc1)NC(=O)c1cc2cc(Cl)ccc2[nH]1
Show InChI InChI=1S/C19H18ClN3O2/c1-21-18(24)16(9-12-5-3-2-4-6-12)23-19(25)17-11-13-10-14(20)7-8-15(13)22-17/h2-8,10-11,16,22H,9H2,1H3,(H,21,24)(H,23,25)/t16-/m0/s1
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n/an/a 110n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against recombinant human liver glycogen phosphorylase a (rHLGPa) catalyzed release of phosphate from glucose-1-phosphat...

J Med Chem 41: 2934-8 (1998)


Article DOI: 10.1021/jm980264k
BindingDB Entry DOI: 10.7270/Q2NS0T1T
More data for this
Ligand-Target Pair
Glycogen phosphorylase, liver form


(Homo sapiens (Human))		BDBM50065965
PNG
(5-Chloro-1H-indole-2-carboxylic acid ((1S,2R)-1-be...)
Show SMILES CN(C)C(=O)[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cc2cc(Cl)ccc2[nH]1
Show InChI InChI=1S/C21H22ClN3O3/c1-25(2)21(28)19(26)17(10-13-6-4-3-5-7-13)24-20(27)18-12-14-11-15(22)8-9-16(14)23-18/h3-9,11-12,17,19,23,26H,10H2,1-2H3,(H,24,27)/t17-,19+/m0/s1
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n/an/a 110n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against recombinant human liver glycogen phosphorylase a (rHLGPa) catalyzed release of phosphate from glucose-1-phosphat...

J Med Chem 41: 2934-8 (1998)


Article DOI: 10.1021/jm980264k
BindingDB Entry DOI: 10.7270/Q2NS0T1T
More data for this
Ligand-Target Pair
Glycogen phosphorylase, liver form


(Homo sapiens (Human))		BDBM50065943
PNG
((S)-2-[(5-Chloro-1H-indole-2-carbonyl)-amino]-3-ph...)
Show SMILES COC(=O)[C@H](Cc1ccccc1)NC(=O)c1cc2cc(Cl)ccc2[nH]1
Show InChI InChI=1S/C19H17ClN2O3/c1-25-19(24)17(9-12-5-3-2-4-6-12)22-18(23)16-11-13-10-14(20)7-8-15(13)21-16/h2-8,10-11,17,21H,9H2,1H3,(H,22,23)/t17-/m0/s1
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n/an/a 140n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against recombinant human liver glycogen phosphorylase a (rHLGPa) catalyzed release of phosphate from glucose-1-phosphat...

J Med Chem 41: 2934-8 (1998)


Article DOI: 10.1021/jm980264k
BindingDB Entry DOI: 10.7270/Q2NS0T1T
More data for this
Ligand-Target Pair
Glycogen phosphorylase, liver form


(Homo sapiens (Human))		BDBM50065962
PNG
(5-Fluoro-1H-indole-2-carboxylic acid ((1S,2R)-1-be...)
Show SMILES CN(C)C(=O)[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cc2cc(F)ccc2[nH]1
Show InChI InChI=1S/C21H22FN3O3/c1-25(2)21(28)19(26)17(10-13-6-4-3-5-7-13)24-20(27)18-12-14-11-15(22)8-9-16(14)23-18/h3-9,11-12,17,19,23,26H,10H2,1-2H3,(H,24,27)/t17-,19+/m0/s1
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n/an/a 170n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against recombinant human liver glycogen phosphorylase a (rHLGPa) catalyzed release of phosphate from glucose-1-phosphat...

J Med Chem 41: 2934-8 (1998)


Article DOI: 10.1021/jm980264k
BindingDB Entry DOI: 10.7270/Q2NS0T1T
More data for this
Ligand-Target Pair
Glycogen phosphorylase, liver form


(Homo sapiens (Human))		BDBM35346
PNG
((S)-5-chloro-N-(3-(4-fluorophenyl)-1-(4-hydroxypip...)
Show SMILES OC1CCN(CC1)C(=O)[C@H](Cc1ccc(F)cc1)NC(=O)c1cc2cc(Cl)ccc2[nH]1 |r|
Show InChI InChI=1S/C23H23ClFN3O3/c24-16-3-6-19-15(12-16)13-20(26-19)22(30)27-21(11-14-1-4-17(25)5-2-14)23(31)28-9-7-18(29)8-10-28/h1-6,12-13,18,21,26,29H,7-11H2,(H,27,30)/t21-/m0/s1
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n/an/a 205n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against recombinant human liver glycogen phosphorylase a (rHLGPa) catalyzed release of phosphate from glucose-1-phosphat...

J Med Chem 41: 2934-8 (1998)


Article DOI: 10.1021/jm980264k
BindingDB Entry DOI: 10.7270/Q2NS0T1T
More data for this
Ligand-Target Pair
Glycogen phosphorylase, liver form


(Homo sapiens (Human))		BDBM50065948
PNG
((2R,3S)-3-[(5-Chloro-1H-indole-2-carbonyl)-amino]-...)
Show SMILES COC(=O)[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cc2cc(Cl)ccc2[nH]1
Show InChI InChI=1S/C20H19ClN2O4/c1-27-20(26)18(24)16(9-12-5-3-2-4-6-12)23-19(25)17-11-13-10-14(21)7-8-15(13)22-17/h2-8,10-11,16,18,22,24H,9H2,1H3,(H,23,25)/t16-,18+/m0/s1
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n/an/a 210n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against recombinant human liver glycogen phosphorylase a (rHLGPa) catalyzed release of phosphate from glucose-1-phosphat...

J Med Chem 41: 2934-8 (1998)


Article DOI: 10.1021/jm980264k
BindingDB Entry DOI: 10.7270/Q2NS0T1T
More data for this
Ligand-Target Pair
Glycogen phosphorylase, liver form


(Homo sapiens (Human))		BDBM50065949
PNG
(5-Chloro-1H-indole-2-carboxylic acid ((R)-1-methyl...)
Show SMILES CNC(=O)[C@@H](Cc1ccccc1)NC(=O)c1cc2cc(Cl)ccc2[nH]1
Show InChI InChI=1S/C19H18ClN3O2/c1-21-18(24)16(9-12-5-3-2-4-6-12)23-19(25)17-11-13-10-14(20)7-8-15(13)22-17/h2-8,10-11,16,22H,9H2,1H3,(H,21,24)(H,23,25)/t16-/m1/s1
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n/an/a 220n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against recombinant human liver glycogen phosphorylase a (rHLGPa) catalyzed release of phosphate from glucose-1-phosphat...

J Med Chem 41: 2934-8 (1998)


Article DOI: 10.1021/jm980264k
BindingDB Entry DOI: 10.7270/Q2NS0T1T
More data for this
Ligand-Target Pair
Glycogen phosphorylase, liver form


(Homo sapiens (Human))		BDBM50065945
PNG
(5-Chloro-1H-indole-2-carboxylic acid ((R)-1-dimeth...)
Show SMILES CN(C)C(=O)[C@@H](Cc1ccccc1)NC(=O)c1cc2cc(Cl)ccc2[nH]1
Show InChI InChI=1S/C20H20ClN3O2/c1-24(2)20(26)18(10-13-6-4-3-5-7-13)23-19(25)17-12-14-11-15(21)8-9-16(14)22-17/h3-9,11-12,18,22H,10H2,1-2H3,(H,23,25)/t18-/m1/s1
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n/an/a 260n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against recombinant human liver glycogen phosphorylase a (rHLGPa) catalyzed release of phosphate from glucose-1-phosphat...

J Med Chem 41: 2934-8 (1998)


Article DOI: 10.1021/jm980264k
BindingDB Entry DOI: 10.7270/Q2NS0T1T
More data for this
Ligand-Target Pair
Glycogen phosphorylase, liver form


(Homo sapiens (Human))		BDBM50065953
PNG
((S)-5-chloro-N-(1-(4-hydroxypiperidin-1-yl)-1-oxo-...)
Show SMILES OC1CCN(CC1)C(=O)[C@H](Cc1ccccc1)NC(=O)c1cc2cc(Cl)ccc2[nH]1
Show InChI InChI=1S/C23H24ClN3O3/c24-17-6-7-19-16(13-17)14-20(25-19)22(29)26-21(12-15-4-2-1-3-5-15)23(30)27-10-8-18(28)9-11-27/h1-7,13-14,18,21,25,28H,8-12H2,(H,26,29)/t21-/m0/s1
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n/an/a 260n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against recombinant human liver glycogen phosphorylase a (rHLGPa) catalyzed release of phosphate from glucose-1-phosphat...

J Med Chem 41: 2934-8 (1998)


Article DOI: 10.1021/jm980264k
BindingDB Entry DOI: 10.7270/Q2NS0T1T
More data for this
Ligand-Target Pair
Glycogen phosphorylase, liver form


(Homo sapiens (Human))		BDBM50065961
PNG
((2R,3S)-3-[(5-Chloro-1H-indole-2-carbonyl)-amino]-...)
Show SMILES O[C@H]([C@H](Cc1ccccc1)NC(=O)c1cc2cc(Cl)ccc2[nH]1)C(O)=O
Show InChI InChI=1S/C19H17ClN2O4/c20-13-6-7-14-12(9-13)10-16(21-14)18(24)22-15(17(23)19(25)26)8-11-4-2-1-3-5-11/h1-7,9-10,15,17,21,23H,8H2,(H,22,24)(H,25,26)/t15-,17+/m0/s1
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n/an/a 330n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against recombinant human liver glycogen phosphorylase a (rHLGPa) catalyzed release of phosphate from glucose-1-phosphat...

J Med Chem 41: 2934-8 (1998)


Article DOI: 10.1021/jm980264k
BindingDB Entry DOI: 10.7270/Q2NS0T1T
More data for this
Ligand-Target Pair
Glycogen phosphorylase, liver form


(Homo sapiens (Human))		BDBM50065968
PNG
(1H-Indole-2-carboxylic acid ((S)-1-dimethylcarbamo...)
Show SMILES CN(C)C(=O)[C@H](Cc1ccccc1)NC(=O)c1cc2ccccc2[nH]1
Show InChI InChI=1S/C20H21N3O2/c1-23(2)20(25)18(12-14-8-4-3-5-9-14)22-19(24)17-13-15-10-6-7-11-16(15)21-17/h3-11,13,18,21H,12H2,1-2H3,(H,22,24)/t18-/m0/s1
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n/an/a 400n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against recombinant human liver glycogen phosphorylase a (rHLGPa) catalyzed release of phosphate from glucose-1-phosphat...

J Med Chem 41: 2934-8 (1998)


Article DOI: 10.1021/jm980264k
BindingDB Entry DOI: 10.7270/Q2NS0T1T
More data for this
Ligand-Target Pair
Glycogen phosphorylase, liver form


(Homo sapiens (Human))		BDBM50065967
PNG
(5-Fluoro-1H-indole-2-carboxylic acid ((S)-1-dimeth...)
Show SMILES CN(C)C(=O)[C@H](Cc1ccccc1)NC(=O)c1cc2cc(F)ccc2[nH]1
Show InChI InChI=1S/C20H20FN3O2/c1-24(2)20(26)18(10-13-6-4-3-5-7-13)23-19(25)17-12-14-11-15(21)8-9-16(14)22-17/h3-9,11-12,18,22H,10H2,1-2H3,(H,23,25)/t18-/m0/s1
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n/an/a 430n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against recombinant human liver glycogen phosphorylase a (rHLGPa) catalyzed release of phosphate from glucose-1-phosphat...

J Med Chem 41: 2934-8 (1998)


Article DOI: 10.1021/jm980264k
BindingDB Entry DOI: 10.7270/Q2NS0T1T
More data for this
Ligand-Target Pair
Glycogen phosphorylase, liver form


(Homo sapiens (Human))		BDBM50065952
PNG
(1H-Indole-2-carboxylic acid ((1S,2R)-1-benzyl-2-di...)
Show SMILES CN(C)C(=O)[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cc2ccccc2[nH]1
Show InChI InChI=1S/C21H23N3O3/c1-24(2)21(27)19(25)17(12-14-8-4-3-5-9-14)23-20(26)18-13-15-10-6-7-11-16(15)22-18/h3-11,13,17,19,22,25H,12H2,1-2H3,(H,23,26)/t17-,19+/m0/s1
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n/an/a 440n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against recombinant human liver glycogen phosphorylase a (rHLGPa) catalyzed release of phosphate from glucose-1-phosphat...

J Med Chem 41: 2934-8 (1998)


Article DOI: 10.1021/jm980264k
BindingDB Entry DOI: 10.7270/Q2NS0T1T
More data for this
Ligand-Target Pair
Glycogen phosphorylase, liver form


(Homo sapiens (Human))		BDBM50065950
PNG
(5-Chloro-1H-indole-2-carboxylic acid ((1S,2R)-1-be...)
Show SMILES CNC(=O)[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cc2cc(Cl)ccc2[nH]1
Show InChI InChI=1S/C20H20ClN3O3/c1-22-20(27)18(25)16(9-12-5-3-2-4-6-12)24-19(26)17-11-13-10-14(21)7-8-15(13)23-17/h2-8,10-11,16,18,23,25H,9H2,1H3,(H,22,27)(H,24,26)/t16-,18+/m0/s1
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n/an/a 680n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against recombinant human liver glycogen phosphorylase a (rHLGPa) catalyzed release of phosphate from glucose-1-phosphat...

J Med Chem 41: 2934-8 (1998)


Article DOI: 10.1021/jm980264k
BindingDB Entry DOI: 10.7270/Q2NS0T1T
More data for this
Ligand-Target Pair
Glycogen phosphorylase, liver form


(Homo sapiens (Human))		BDBM50065964
PNG
(5-Chloro-1H-indole-2-carboxylic acid ((1R,2R)-1-be...)
Show SMILES CN(C)C(=O)[C@H](O)[C@@H](Cc1ccccc1)NC(=O)c1cc2cc(Cl)ccc2[nH]1
Show InChI InChI=1S/C21H22ClN3O3/c1-25(2)21(28)19(26)17(10-13-6-4-3-5-7-13)24-20(27)18-12-14-11-15(22)8-9-16(14)23-18/h3-9,11-12,17,19,23,26H,10H2,1-2H3,(H,24,27)/t17-,19-/m1/s1
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n/an/a 1.70E+3n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against recombinant human liver glycogen phosphorylase a (rHLGPa) catalyzed release of phosphate from glucose-1-phosphat...

J Med Chem 41: 2934-8 (1998)


Article DOI: 10.1021/jm980264k
BindingDB Entry DOI: 10.7270/Q2NS0T1T
More data for this
Ligand-Target Pair
Glycogen phosphorylase, liver form


(Homo sapiens (Human))		BDBM50065966
PNG
((S)-2-[(5-Chloro-1H-indole-2-carbonyl)-amino]-3-ph...)
Show SMILES OC(=O)[C@H](Cc1ccccc1)NC(=O)c1cc2cc(Cl)ccc2[nH]1
Show InChI InChI=1S/C18H15ClN2O3/c19-13-6-7-14-12(9-13)10-15(20-14)17(22)21-16(18(23)24)8-11-4-2-1-3-5-11/h1-7,9-10,16,20H,8H2,(H,21,22)(H,23,24)/t16-/m0/s1
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n/an/a 1.70E+3n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against recombinant human liver glycogen phosphorylase a (rHLGPa) catalyzed release of phosphate from glucose-1-phosphat...

J Med Chem 41: 2934-8 (1998)


Article DOI: 10.1021/jm980264k
BindingDB Entry DOI: 10.7270/Q2NS0T1T
More data for this
Ligand-Target Pair
Glycogen phosphorylase, liver form


(Homo sapiens (Human))		BDBM50065957
PNG
(5-Chloro-1H-indole-2-carboxylic acid ((1S,2R)-1-be...)
Show SMILES NC(=O)[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cc2cc(Cl)ccc2[nH]1
Show InChI InChI=1S/C19H18ClN3O3/c20-13-6-7-14-12(9-13)10-16(22-14)19(26)23-15(17(24)18(21)25)8-11-4-2-1-3-5-11/h1-7,9-10,15,17,22,24H,8H2,(H2,21,25)(H,23,26)/t15-,17+/m0/s1
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n/an/a 1.70E+3n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against recombinant human liver glycogen phosphorylase a (rHLGPa) catalyzed release of phosphate from glucose-1-phosphat...

J Med Chem 41: 2934-8 (1998)


Article DOI: 10.1021/jm980264k
BindingDB Entry DOI: 10.7270/Q2NS0T1T
More data for this
Ligand-Target Pair
Glycogen phosphorylase, liver form


(Homo sapiens (Human))		BDBM50065960
PNG
(5-Chloro-1H-indole-2-carboxylic acid ((1R,2S)-1-be...)
Show SMILES CN(C)C(=O)[C@@H](O)[C@@H](Cc1ccccc1)NC(=O)c1cc2cc(Cl)ccc2[nH]1
Show InChI InChI=1S/C21H22ClN3O3/c1-25(2)21(28)19(26)17(10-13-6-4-3-5-7-13)24-20(27)18-12-14-11-15(22)8-9-16(14)23-18/h3-9,11-12,17,19,23,26H,10H2,1-2H3,(H,24,27)/t17-,19+/m1/s1
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n/an/a 1.80E+3n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against recombinant human liver glycogen phosphorylase a (rHLGPa) catalyzed release of phosphate from glucose-1-phosphat...

J Med Chem 41: 2934-8 (1998)


Article DOI: 10.1021/jm980264k
BindingDB Entry DOI: 10.7270/Q2NS0T1T
More data for this
Ligand-Target Pair
Glycogen phosphorylase, liver form


(Homo sapiens (Human))		BDBM50065956
PNG
(5-Methoxy-1H-indole-2-carboxylic acid ((S)-1-dimet...)
Show SMILES COc1ccc2[nH]c(cc2c1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N(C)C
Show InChI InChI=1S/C21H23N3O3/c1-24(2)21(26)19(11-14-7-5-4-6-8-14)23-20(25)18-13-15-12-16(27-3)9-10-17(15)22-18/h4-10,12-13,19,22H,11H2,1-3H3,(H,23,25)/t19-/m0/s1
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n/an/a 4.70E+3n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against recombinant human liver glycogen phosphorylase a (rHLGPa) catalyzed release of phosphate from glucose-1-phosphat...

J Med Chem 41: 2934-8 (1998)


Article DOI: 10.1021/jm980264k
BindingDB Entry DOI: 10.7270/Q2NS0T1T
More data for this
Ligand-Target Pair
Glycogen phosphorylase, liver form


(Homo sapiens (Human))		BDBM50065963
PNG
(5-Chloro-1H-indole-2-carboxylic acid ((1S,2R)-1-cy...)
Show SMILES CN(C)C(=O)[C@H](O)[C@H](CC1CCCCC1)NC(=O)c1cc2cc(Cl)ccc2[nH]1
Show InChI InChI=1S/C21H28ClN3O3/c1-25(2)21(28)19(26)17(10-13-6-4-3-5-7-13)24-20(27)18-12-14-11-15(22)8-9-16(14)23-18/h8-9,11-13,17,19,23,26H,3-7,10H2,1-2H3,(H,24,27)/t17-,19+/m0/s1
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n/an/a 6.50E+3n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against recombinant human liver glycogen phosphorylase a (rHLGPa) catalyzed release of phosphate from glucose-1-phosphat...

J Med Chem 41: 2934-8 (1998)


Article DOI: 10.1021/jm980264k
BindingDB Entry DOI: 10.7270/Q2NS0T1T
More data for this
Ligand-Target Pair
Glycogen phosphorylase, liver form


(Homo sapiens (Human))		BDBM50065946
PNG
(5-Chloro-1H-indole-2-carboxylic acid ((1S,2R)-1-be...)
Show SMILES OC[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cc2cc(Cl)ccc2[nH]1
Show InChI InChI=1S/C19H19ClN2O3/c20-14-6-7-15-13(9-14)10-17(21-15)19(25)22-16(18(24)11-23)8-12-4-2-1-3-5-12/h1-7,9-10,16,18,21,23-24H,8,11H2,(H,22,25)/t16-,18-/m0/s1
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n/an/a 6.80E+3n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against recombinant human liver glycogen phosphorylase a (rHLGPa) catalyzed release of phosphate from glucose-1-phosphat...

J Med Chem 41: 2934-8 (1998)


Article DOI: 10.1021/jm980264k
BindingDB Entry DOI: 10.7270/Q2NS0T1T
More data for this
Ligand-Target Pair
Glycogen phosphorylase, liver form


(Homo sapiens (Human))		BDBM50065958
PNG
(5-Chloro-1H-indole-2-carboxylic acid ((1S,2S)-1-be...)
Show SMILES CN(C)C(=O)[C@@H](O)[C@H](Cc1ccccc1)NC(=O)c1cc2cc(Cl)ccc2[nH]1
Show InChI InChI=1S/C21H22ClN3O3/c1-25(2)21(28)19(26)17(10-13-6-4-3-5-7-13)24-20(27)18-12-14-11-15(22)8-9-16(14)23-18/h3-9,11-12,17,19,23,26H,10H2,1-2H3,(H,24,27)/t17-,19-/m0/s1
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n/an/a 8.70E+3n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against recombinant human liver glycogen phosphorylase a (rHLGPa) catalyzed release of phosphate from glucose-1-phosphat...

J Med Chem 41: 2934-8 (1998)


Article DOI: 10.1021/jm980264k
BindingDB Entry DOI: 10.7270/Q2NS0T1T
More data for this
Ligand-Target Pair
Glycogen phosphorylase, liver form


(Homo sapiens (Human))		BDBM50065959
PNG
(5-Chloro-1H-indole-2-carboxylic acid ((S)-1-hydrox...)
Show SMILES OC[C@H](Cc1ccccc1)NC(=O)c1cc2cc(Cl)ccc2[nH]1
Show InChI InChI=1S/C18H17ClN2O2/c19-14-6-7-16-13(9-14)10-17(21-16)18(23)20-15(11-22)8-12-4-2-1-3-5-12/h1-7,9-10,15,21-22H,8,11H2,(H,20,23)/t15-/m0/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against recombinant human liver glycogen phosphorylase a (rHLGPa) catalyzed release of phosphate from glucose-1-phosphat...

J Med Chem 41: 2934-8 (1998)


Article DOI: 10.1021/jm980264k
BindingDB Entry DOI: 10.7270/Q2NS0T1T
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%