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USPatent US10280167

Compile data set for download or QSAR
Found 39 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
RNA-directed RNA polymerase


(Hepatitis C virus)		BDBM384083
PNG
(US10280167, Example 6)
Show SMILES CCc1[nH]c(nc1C1CC1)-c1nc(N)c2[nH]c(=O)n(Cc3ccccc3)c2n1
Show InChI InChI=1S/C20H21N7O/c1-2-13-14(12-8-9-12)23-17(22-13)18-25-16(21)15-19(26-18)27(20(28)24-15)10-11-6-4-3-5-7-11/h3-7,12H,2,8-10H2,1H3,(H,22,23)(H,24,28)(H2,21,25,26)
PDB

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n/an/an/an/a 53n/an/an/an/a



University of Nottingham



Assay Description
Activation of human TLR7 results in robust production of interferon by plasmacytoid dendritic cells present in human blood. The potential of compound...

Br J Pharmacol 144: 317-22 (2005)


BindingDB Entry DOI: 10.7270/Q2Z60RDV
More data for this
Ligand-Target Pair
RNA-directed RNA polymerase


(Hepatitis C virus)		BDBM384108
PNG
(US10280167, Example 53)
Show SMILES Cc1cn[nH]c1-c1nc(N)c2[nH]c(=O)n(Cc3ccccc3)c2n1
Show InChI InChI=1S/C16H15N7O/c1-9-7-18-22-11(9)14-20-13(17)12-15(21-14)23(16(24)19-12)8-10-5-3-2-4-6-10/h2-7H,8H2,1H3,(H,18,22)(H,19,24)(H2,17,20,21)
PDB

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n/an/an/an/a 760n/an/an/an/a



University of Nottingham



Assay Description
Activation of human TLR7 results in robust production of interferon by plasmacytoid dendritic cells present in human blood. The potential of compound...

Br J Pharmacol 144: 317-22 (2005)


BindingDB Entry DOI: 10.7270/Q2Z60RDV
More data for this
Ligand-Target Pair
RNA-directed RNA polymerase


(Hepatitis C virus)		BDBM384082
PNG
(US10280167, Example 5)
Show SMILES Cc1[nH]c(nc1C1CC1)-c1nc(N)c2[nH]c(=O)n(Cc3ccccc3)c2n1
Show InChI InChI=1S/C19H19N7O/c1-10-13(12-7-8-12)22-16(21-10)17-24-15(20)14-18(25-17)26(19(27)23-14)9-11-5-3-2-4-6-11/h2-6,12H,7-9H2,1H3,(H,21,22)(H,23,27)(H2,20,24,25)
PDB

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University of Nottingham



Assay Description
Activation of human TLR7 results in robust production of interferon by plasmacytoid dendritic cells present in human blood. The potential of compound...

Br J Pharmacol 144: 317-22 (2005)


BindingDB Entry DOI: 10.7270/Q2Z60RDV
More data for this
Ligand-Target Pair
RNA-directed RNA polymerase


(Hepatitis C virus)		BDBM384084
PNG
(US10280167, Example 7)
Show SMILES Cc1nc([nH]c1C)-c1nc(N)c2[nH]c(=O)n(Cc3ccccc3)c2n1
Show InChI InChI=1S/C17H17N7O/c1-9-10(2)20-14(19-9)15-22-13(18)12-16(23-15)24(17(25)21-12)8-11-6-4-3-5-7-11/h3-7H,8H2,1-2H3,(H,19,20)(H,21,25)(H2,18,22,23)
PDB

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University of Nottingham



Assay Description
Activation of human TLR7 results in robust production of interferon by plasmacytoid dendritic cells present in human blood. The potential of compound...

Br J Pharmacol 144: 317-22 (2005)


BindingDB Entry DOI: 10.7270/Q2Z60RDV
More data for this
Ligand-Target Pair
RNA-directed RNA polymerase


(Hepatitis C virus)		BDBM384085
PNG
(US10280167, Example 8)
Show SMILES Cc1c[nH]c(n1)-c1nc(N)c2[nH]c(=O)n(Cc3ccccc3)c2n1
Show InChI InChI=1S/C16H15N7O/c1-9-7-18-13(19-9)14-21-12(17)11-15(22-14)23(16(24)20-11)8-10-5-3-2-4-6-10/h2-7H,8H2,1H3,(H,18,19)(H,20,24)(H2,17,21,22)
PDB

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University of Nottingham



Assay Description
Activation of human TLR7 results in robust production of interferon by plasmacytoid dendritic cells present in human blood. The potential of compound...

Br J Pharmacol 144: 317-22 (2005)


BindingDB Entry DOI: 10.7270/Q2Z60RDV
More data for this
Ligand-Target Pair
RNA-directed RNA polymerase


(Hepatitis C virus)		BDBM384087
PNG
(US10280167, Example 10)
Show SMILES Nc1nc(nc2n(CC3CCOCC3)c(=O)[nH]c12)-c1nc(c[nH]1)C1CC1
Show InChI InChI=1S/C17H21N7O2/c18-13-12-16(24(17(25)21-12)8-9-3-5-26-6-4-9)23-15(22-13)14-19-7-11(20-14)10-1-2-10/h7,9-10H,1-6,8H2,(H,19,20)(H,21,25)(H2,18,22,23)
PDB

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n/an/an/an/a 730n/an/an/an/a



University of Nottingham



Assay Description
Activation of human TLR7 results in robust production of interferon by plasmacytoid dendritic cells present in human blood. The potential of compound...

Br J Pharmacol 144: 317-22 (2005)


BindingDB Entry DOI: 10.7270/Q2Z60RDV
More data for this
Ligand-Target Pair
RNA-directed RNA polymerase


(Hepatitis C virus)		BDBM384096
PNG
(US10280167, Example 25)
Show SMILES Nc1nc(nc2n(Cc3cccc(CN4CCCC4)c3)c(=O)[nH]c12)-c1ncc[nH]1
Show InChI InChI=1S/C20H22N8O/c21-16-15-19(26-18(25-16)17-22-6-7-23-17)28(20(29)24-15)12-14-5-3-4-13(10-14)11-27-8-1-2-9-27/h3-7,10H,1-2,8-9,11-12H2,(H,22,23)(H,24,29)(H2,21,25,26)
PDB

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n/an/an/an/a 6n/an/an/an/a



University of Nottingham



Assay Description
Activation of human TLR7 results in robust production of interferon by plasmacytoid dendritic cells present in human blood. The potential of compound...

Br J Pharmacol 144: 317-22 (2005)


BindingDB Entry DOI: 10.7270/Q2Z60RDV
More data for this
Ligand-Target Pair
RNA-directed RNA polymerase


(Hepatitis C virus)		BDBM384100
PNG
(US10280167, Example 29)
Show SMILES CC(C)c1c[nH]c(n1)-c1nc(N)c2[nH]c(=O)n(Cc3ccccc3)c2n1
Show InChI InChI=1S/C18H19N7O/c1-10(2)12-8-20-15(21-12)16-23-14(19)13-17(24-16)25(18(26)22-13)9-11-6-4-3-5-7-11/h3-8,10H,9H2,1-2H3,(H,20,21)(H,22,26)(H2,19,23,24)
PDB

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n/an/an/an/a 1.66E+3n/an/an/an/a



University of Nottingham



Assay Description
Activation of human TLR7 results in robust production of interferon by plasmacytoid dendritic cells present in human blood. The potential of compound...

Br J Pharmacol 144: 317-22 (2005)


BindingDB Entry DOI: 10.7270/Q2Z60RDV
More data for this
Ligand-Target Pair
RNA-directed RNA polymerase


(Hepatitis C virus)		BDBM384103
PNG
(US10280167, Example 32)
Show SMILES Nc1nc(nc2n(Cc3ccccc3)c(=O)[nH]c12)-c1cnco1
Show InChI InChI=1S/C15H12N6O2/c16-12-11-14(20-13(19-12)10-6-17-8-23-10)21(15(22)18-11)7-9-4-2-1-3-5-9/h1-6,8H,7H2,(H,18,22)(H2,16,19,20)
PDB

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n/an/an/an/a 1.51E+3n/an/an/an/a



University of Nottingham



Assay Description
Activation of human TLR7 results in robust production of interferon by plasmacytoid dendritic cells present in human blood. The potential of compound...

Br J Pharmacol 144: 317-22 (2005)


BindingDB Entry DOI: 10.7270/Q2Z60RDV
More data for this
Ligand-Target Pair
RNA-directed RNA polymerase


(Hepatitis C virus)		BDBM384106
PNG
(US10280167, Example 35)
Show SMILES Cc1cnn(c1)-c1nc(N)c2[nH]c(=O)n(Cc3ccccc3)c2n1
Show InChI InChI=1S/C16H15N7O/c1-10-7-18-23(8-10)15-20-13(17)12-14(21-15)22(16(24)19-12)9-11-5-3-2-4-6-11/h2-8H,9H2,1H3,(H,19,24)(H2,17,20,21)
PDB

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University of Nottingham



Assay Description
Activation of human TLR7 results in robust production of interferon by plasmacytoid dendritic cells present in human blood. The potential of compound...

Br J Pharmacol 144: 317-22 (2005)


BindingDB Entry DOI: 10.7270/Q2Z60RDV
More data for this
Ligand-Target Pair
RNA-directed RNA polymerase


(Hepatitis C virus)		BDBM384112
PNG
(US10280167, Example 58)
Show SMILES Nc1nc(nc2n(Cc3ccc(OCC(O)=O)nc3)c(=O)[nH]c12)-c1ncc[nH]1
Show InChI InChI=1S/C16H14N8O4/c17-12-11-15(23-14(22-12)13-18-3-4-19-13)24(16(27)21-11)6-8-1-2-9(20-5-8)28-7-10(25)26/h1-5H,6-7H2,(H,18,19)(H,21,27)(H,25,26)(H2,17,22,23)
PDB

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n/an/an/an/a 2.75E+3n/an/an/an/a



University of Nottingham



Assay Description
Activation of human TLR7 results in robust production of interferon by plasmacytoid dendritic cells present in human blood. The potential of compound...

Br J Pharmacol 144: 317-22 (2005)


BindingDB Entry DOI: 10.7270/Q2Z60RDV
More data for this
Ligand-Target Pair
RNA-directed RNA polymerase


(Hepatitis C virus)		BDBM384114
PNG
(US10280167, Example 61)
Show SMILES CN1CCN(CCCCCn2c3nc(nc(N)c3[nH]c2=O)-c2ncc[nH]2)CC1
Show InChI InChI=1S/C18H27N9O/c1-25-9-11-26(12-10-25)7-3-2-4-8-27-17-13(22-18(27)28)14(19)23-16(24-17)15-20-5-6-21-15/h5-6H,2-4,7-12H2,1H3,(H,20,21)(H,22,28)(H2,19,23,24)
PDB

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n/an/an/an/a 1.34E+3n/an/an/an/a



University of Nottingham



Assay Description
Activation of human TLR7 results in robust production of interferon by plasmacytoid dendritic cells present in human blood. The potential of compound...

Br J Pharmacol 144: 317-22 (2005)


BindingDB Entry DOI: 10.7270/Q2Z60RDV
More data for this
Ligand-Target Pair
RNA-directed RNA polymerase


(Hepatitis C virus)		BDBM384086
PNG
(US10280167, Example 9)
Show SMILES Cc1ccc(Cn2c3nc(nc(N)c3[nH]c2=O)-c2ncc[nH]2)cn1
Show InChI InChI=1S/C15H14N8O/c1-8-2-3-9(6-19-8)7-23-14-10(20-15(23)24)11(16)21-13(22-14)12-17-4-5-18-12/h2-6H,7H2,1H3,(H,17,18)(H,20,24)(H2,16,21,22)
PDB

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University of Nottingham



Assay Description
Activation of human TLR7 results in robust production of interferon by plasmacytoid dendritic cells present in human blood. The potential of compound...

Br J Pharmacol 144: 317-22 (2005)


BindingDB Entry DOI: 10.7270/Q2Z60RDV
More data for this
Ligand-Target Pair
RNA-directed RNA polymerase


(Hepatitis C virus)		BDBM384091
PNG
(US10280167, Example 18)
Show SMILES Nc1nc(nc2n(Cc3ccccc3)c(=O)[nH]c12)-c1ccc[nH]1
Show InChI InChI=1S/C16H14N6O/c17-13-12-15(21-14(20-13)11-7-4-8-18-11)22(16(23)19-12)9-10-5-2-1-3-6-10/h1-8,18H,9H2,(H,19,23)(H2,17,20,21)
PDB

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n/an/an/an/a 2.58E+3n/an/an/an/a



University of Nottingham



Assay Description
Activation of human TLR7 results in robust production of interferon by plasmacytoid dendritic cells present in human blood. The potential of compound...

Br J Pharmacol 144: 317-22 (2005)


BindingDB Entry DOI: 10.7270/Q2Z60RDV
More data for this
Ligand-Target Pair
RNA-directed RNA polymerase


(Hepatitis C virus)		BDBM384098
PNG
(US10280167, Example 27)
Show SMILES Nc1nc(nc2n(Cc3ccccc3)c(=O)[nH]c12)-c1nccn1CCO
Show InChI InChI=1S/C17H17N7O2/c18-13-12-15(22-14(21-13)16-19-6-7-23(16)8-9-25)24(17(26)20-12)10-11-4-2-1-3-5-11/h1-7,25H,8-10H2,(H,20,26)(H2,18,21,22)
PDB

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University of Nottingham



Assay Description
Activation of human TLR7 results in robust production of interferon by plasmacytoid dendritic cells present in human blood. The potential of compound...

Br J Pharmacol 144: 317-22 (2005)


BindingDB Entry DOI: 10.7270/Q2Z60RDV
More data for this
Ligand-Target Pair
RNA-directed RNA polymerase


(Hepatitis C virus)		BDBM384101
PNG
(US10280167, Example 30)
Show SMILES CCc1c[nH]c(n1)-c1nc(N)c2[nH]c(=O)n(Cc3ccccc3)c2n1
Show InChI InChI=1S/C17H17N7O/c1-2-11-8-19-14(20-11)15-22-13(18)12-16(23-15)24(17(25)21-12)9-10-6-4-3-5-7-10/h3-8H,2,9H2,1H3,(H,19,20)(H,21,25)(H2,18,22,23)
PDB

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University of Nottingham



Assay Description
Activation of human TLR7 results in robust production of interferon by plasmacytoid dendritic cells present in human blood. The potential of compound...

Br J Pharmacol 144: 317-22 (2005)


BindingDB Entry DOI: 10.7270/Q2Z60RDV
More data for this
Ligand-Target Pair
RNA-directed RNA polymerase


(Hepatitis C virus)		BDBM384109
PNG
(US10280167, Example 54)
Show SMILES CN(C)CCOc1ccc(Cn2c3nc(nc(N)c3[nH]c2=O)-c2nc(c[nH]2)C2CC2)cn1
Show InChI InChI=1S/C21H25N9O2/c1-29(2)7-8-32-15-6-3-12(9-23-15)11-30-20-16(26-21(30)31)17(22)27-19(28-20)18-24-10-14(25-18)13-4-5-13/h3,6,9-10,13H,4-5,7-8,11H2,1-2H3,(H,24,25)(H,26,31)(H2,22,27,28)
PDB

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Assay Description
Activation of human TLR7 results in robust production of interferon by plasmacytoid dendritic cells present in human blood. The potential of compound...

Br J Pharmacol 144: 317-22 (2005)


BindingDB Entry DOI: 10.7270/Q2Z60RDV
More data for this
Ligand-Target Pair
RNA-directed RNA polymerase


(Hepatitis C virus)		BDBM384113
PNG
(US10280167, Example 60)
Show SMILES Nc1nc(nc2n(Cc3ccc4CCNCc4c3)c(=O)[nH]c12)-c1nc(c[nH]1)C1CC1
Show InChI InChI=1S/C21H22N8O/c22-17-16-20(28-19(27-17)18-24-9-15(25-18)13-3-4-13)29(21(30)26-16)10-11-1-2-12-5-6-23-8-14(12)7-11/h1-2,7,9,13,23H,3-6,8,10H2,(H,24,25)(H,26,30)(H2,22,27,28)
PDB

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University of Nottingham



Assay Description
Activation of human TLR7 results in robust production of interferon by plasmacytoid dendritic cells present in human blood. The potential of compound...

Br J Pharmacol 144: 317-22 (2005)


BindingDB Entry DOI: 10.7270/Q2Z60RDV
More data for this
Ligand-Target Pair
RNA-directed RNA polymerase


(Hepatitis C virus)		BDBM384078
PNG
(US10280167, Example 1)
Show SMILES Nc1nc(nc2n(Cc3ccccc3)c(=O)[nH]c12)-c1nc(c[nH]1)C1CC1
Show InChI InChI=1S/C18H17N7O/c19-14-13-17(25(18(26)22-13)9-10-4-2-1-3-5-10)24-16(23-14)15-20-8-12(21-15)11-6-7-11/h1-5,8,11H,6-7,9H2,(H,20,21)(H,22,26)(H2,19,23,24)
PDB

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University of Nottingham



Assay Description
Activation of human TLR7 results in robust production of interferon by plasmacytoid dendritic cells present in human blood. The potential of compound...

Br J Pharmacol 144: 317-22 (2005)


BindingDB Entry DOI: 10.7270/Q2Z60RDV
More data for this
Ligand-Target Pair
RNA-directed RNA polymerase


(Hepatitis C virus)		BDBM384080
PNG
(US10280167, Example 3)
Show SMILES Nc1nc(nc2n(Cc3ccccc3)c(=O)[nH]c12)-c1nc(c[nH]1)C1CCCC1
Show InChI InChI=1S/C20H21N7O/c21-16-15-19(27(20(28)24-15)11-12-6-2-1-3-7-12)26-18(25-16)17-22-10-14(23-17)13-8-4-5-9-13/h1-3,6-7,10,13H,4-5,8-9,11H2,(H,22,23)(H,24,28)(H2,21,25,26)
PDB

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n/an/an/an/a 1.40E+4n/an/an/an/a



University of Nottingham



Assay Description
Activation of human TLR7 results in robust production of interferon by plasmacytoid dendritic cells present in human blood. The potential of compound...

Br J Pharmacol 144: 317-22 (2005)


BindingDB Entry DOI: 10.7270/Q2Z60RDV
More data for this
Ligand-Target Pair
RNA-directed RNA polymerase


(Hepatitis C virus)		BDBM384104
PNG
(US10280167, Example 33)
Show SMILES Cc1noc(n1)-c1nc(N)c2[nH]c(=O)n(Cc3ccccc3)c2n1
Show InChI InChI=1S/C15H13N7O2/c1-8-17-14(24-21-8)12-19-11(16)10-13(20-12)22(15(23)18-10)7-9-5-3-2-4-6-9/h2-6H,7H2,1H3,(H,18,23)(H2,16,19,20)
PDB

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n/an/an/an/a 810n/an/an/an/a



University of Nottingham



Assay Description
Activation of human TLR7 results in robust production of interferon by plasmacytoid dendritic cells present in human blood. The potential of compound...

Br J Pharmacol 144: 317-22 (2005)


BindingDB Entry DOI: 10.7270/Q2Z60RDV
More data for this
Ligand-Target Pair
RNA-directed RNA polymerase


(Hepatitis C virus)		BDBM384105
PNG
(US10280167, Example 34)
Show SMILES COCCc1nnc(o1)-c1nc(N)c2[nH]c(=O)n(Cc3ccccc3)c2n1
Show InChI InChI=1S/C17H17N7O3/c1-26-8-7-11-22-23-16(27-11)14-20-13(18)12-15(21-14)24(17(25)19-12)9-10-5-3-2-4-6-10/h2-6H,7-9H2,1H3,(H,19,25)(H2,18,20,21)
PDB

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n/an/an/an/a 690n/an/an/an/a



University of Nottingham



Assay Description
Activation of human TLR7 results in robust production of interferon by plasmacytoid dendritic cells present in human blood. The potential of compound...

Br J Pharmacol 144: 317-22 (2005)


BindingDB Entry DOI: 10.7270/Q2Z60RDV
More data for this
Ligand-Target Pair
RNA-directed RNA polymerase


(Hepatitis C virus)		BDBM384111
PNG
(US10280167, Example 57)
Show SMILES COC(=O)COc1ccc(Cn2c3nc(nc(N)c3[nH]c2=O)-c2ncc[nH]2)cn1
Show InChI InChI=1S/C17H16N8O4/c1-28-11(26)8-29-10-3-2-9(6-21-10)7-25-16-12(22-17(25)27)13(18)23-15(24-16)14-19-4-5-20-14/h2-6H,7-8H2,1H3,(H,19,20)(H,22,27)(H2,18,23,24)
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n/an/an/an/a 1.21E+3n/an/an/an/a



University of Nottingham



Assay Description
Activation of human TLR7 results in robust production of interferon by plasmacytoid dendritic cells present in human blood. The potential of compound...

Br J Pharmacol 144: 317-22 (2005)


BindingDB Entry DOI: 10.7270/Q2Z60RDV
More data for this
Ligand-Target Pair
RNA-directed RNA polymerase


(Hepatitis C virus)		BDBM384081
PNG
(US10280167, Example 4)
Show SMILES Nc1nc(nc2n(Cc3ccccc3)c(=O)[nH]c12)-c1ncc[nH]1
Show InChI InChI=1S/C15H13N7O/c16-11-10-14(21-13(20-11)12-17-6-7-18-12)22(15(23)19-10)8-9-4-2-1-3-5-9/h1-7H,8H2,(H,17,18)(H,19,23)(H2,16,20,21)
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Assay Description
Activation of human TLR7 results in robust production of interferon by plasmacytoid dendritic cells present in human blood. The potential of compound...

Br J Pharmacol 144: 317-22 (2005)


BindingDB Entry DOI: 10.7270/Q2Z60RDV
More data for this
Ligand-Target Pair
RNA-directed RNA polymerase


(Hepatitis C virus)		BDBM384089
PNG
(US10280167, Example 12)
Show SMILES Cn1ccnc1-c1nc(N)c2[nH]c(=O)n(Cc3ccccc3)c2n1
Show InChI InChI=1S/C16H15N7O/c1-22-8-7-18-15(22)13-20-12(17)11-14(21-13)23(16(24)19-11)9-10-5-3-2-4-6-10/h2-8H,9H2,1H3,(H,19,24)(H2,17,20,21)
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Assay Description
Activation of human TLR7 results in robust production of interferon by plasmacytoid dendritic cells present in human blood. The potential of compound...

Br J Pharmacol 144: 317-22 (2005)


BindingDB Entry DOI: 10.7270/Q2Z60RDV
More data for this
Ligand-Target Pair
RNA-directed RNA polymerase


(Hepatitis C virus)		BDBM384090
PNG
(US10280167, Example 15)
Show SMILES Nc1nc(nc2n(Cc3ccccc3)c(=O)[nH]c12)-c1cncnc1
Show InChI InChI=1S/C16H13N7O/c17-13-12-15(22-14(21-13)11-6-18-9-19-7-11)23(16(24)20-12)8-10-4-2-1-3-5-10/h1-7,9H,8H2,(H,20,24)(H2,17,21,22)
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n/an/an/an/a 1.69E+4n/an/an/an/a



University of Nottingham



Assay Description
Activation of human TLR7 results in robust production of interferon by plasmacytoid dendritic cells present in human blood. The potential of compound...

Br J Pharmacol 144: 317-22 (2005)


BindingDB Entry DOI: 10.7270/Q2Z60RDV
More data for this
Ligand-Target Pair
RNA-directed RNA polymerase


(Hepatitis C virus)		BDBM384097
PNG
(US10280167, Example 26)
Show SMILES Cc1ccc(Cn2c3nc(nc(N)c3[nH]c2=O)-c2nc(c[nH]2)C2CC2)cn1
Show InChI InChI=1S/C18H18N8O/c1-9-2-3-10(6-20-9)8-26-17-13(23-18(26)27)14(19)24-16(25-17)15-21-7-12(22-15)11-4-5-11/h2-3,6-7,11H,4-5,8H2,1H3,(H,21,22)(H,23,27)(H2,19,24,25)
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Assay Description
Activation of human TLR7 results in robust production of interferon by plasmacytoid dendritic cells present in human blood. The potential of compound...

Br J Pharmacol 144: 317-22 (2005)


BindingDB Entry DOI: 10.7270/Q2Z60RDV
More data for this
Ligand-Target Pair
RNA-directed RNA polymerase


(Hepatitis C virus)		BDBM384115
PNG
(US10280167, Example 62)
Show SMILES Nc1nc(nc2n(CCCCCCN3CCCC3)c(=O)[nH]c12)-c1nc(c[nH]1)C1CC1
Show InChI InChI=1S/C21H30N8O/c22-17-16-20(27-19(26-17)18-23-13-15(24-18)14-7-8-14)29(21(30)25-16)12-4-2-1-3-9-28-10-5-6-11-28/h13-14H,1-12H2,(H,23,24)(H,25,30)(H2,22,26,27)
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Assay Description
Activation of human TLR7 results in robust production of interferon by plasmacytoid dendritic cells present in human blood. The potential of compound...

Br J Pharmacol 144: 317-22 (2005)


BindingDB Entry DOI: 10.7270/Q2Z60RDV
More data for this
Ligand-Target Pair
RNA-directed RNA polymerase


(Hepatitis C virus)		BDBM384088
PNG
(US10280167, Example 11)
Show SMILES COCCn1ccnc1-c1nc(N)c2[nH]c(=O)n(Cc3ccccc3)c2n1
Show InChI InChI=1S/C18H19N7O2/c1-27-10-9-24-8-7-20-17(24)15-22-14(19)13-16(23-15)25(18(26)21-13)11-12-5-3-2-4-6-12/h2-8H,9-11H2,1H3,(H,21,26)(H2,19,22,23)
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Assay Description
Activation of human TLR7 results in robust production of interferon by plasmacytoid dendritic cells present in human blood. The potential of compound...

Br J Pharmacol 144: 317-22 (2005)


BindingDB Entry DOI: 10.7270/Q2Z60RDV
More data for this
Ligand-Target Pair
RNA-directed RNA polymerase


(Hepatitis C virus)		BDBM384093
PNG
(US10280167, Example 20)
Show SMILES Nc1nc(nc2n(Cc3ccccc3)c(=O)[nH]c12)-c1ccco1
Show InChI InChI=1S/C16H13N5O2/c17-13-12-15(20-14(19-13)11-7-4-8-23-11)21(16(22)18-12)9-10-5-2-1-3-6-10/h1-8H,9H2,(H,18,22)(H2,17,19,20)
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Assay Description
Activation of human TLR7 results in robust production of interferon by plasmacytoid dendritic cells present in human blood. The potential of compound...

Br J Pharmacol 144: 317-22 (2005)


BindingDB Entry DOI: 10.7270/Q2Z60RDV
More data for this
Ligand-Target Pair
RNA-directed RNA polymerase


(Hepatitis C virus)		BDBM384099
PNG
(US10280167, Example 28)
Show SMILES CC(C)(C)c1c[nH]c(n1)-c1nc(N)c2[nH]c(=O)n(Cc3ccccc3)c2n1
Show InChI InChI=1S/C19H21N7O/c1-19(2,3)12-9-21-15(22-12)16-24-14(20)13-17(25-16)26(18(27)23-13)10-11-7-5-4-6-8-11/h4-9H,10H2,1-3H3,(H,21,22)(H,23,27)(H2,20,24,25)
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n/an/an/an/a>2.38E+4n/an/an/an/a



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Assay Description
Activation of human TLR7 results in robust production of interferon by plasmacytoid dendritic cells present in human blood. The potential of compound...

Br J Pharmacol 144: 317-22 (2005)


BindingDB Entry DOI: 10.7270/Q2Z60RDV
More data for this
Ligand-Target Pair
RNA-directed RNA polymerase


(Hepatitis C virus)		BDBM384095
PNG
(US10280167, Example 24)
Show SMILES Nc1nc(nc2n(Cc3ccc4CCNCc4c3)c(=O)[nH]c12)-c1ncc[nH]1
Show InChI InChI=1S/C18H18N8O/c19-14-13-17(25-16(24-14)15-21-5-6-22-15)26(18(27)23-13)9-10-1-2-11-3-4-20-8-12(11)7-10/h1-2,5-7,20H,3-4,8-9H2,(H,21,22)(H,23,27)(H2,19,24,25)
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Assay Description
Activation of human TLR7 results in robust production of interferon by plasmacytoid dendritic cells present in human blood. The potential of compound...

Br J Pharmacol 144: 317-22 (2005)


BindingDB Entry DOI: 10.7270/Q2Z60RDV
More data for this
Ligand-Target Pair
RNA-directed RNA polymerase


(Hepatitis C virus)		BDBM384102
PNG
(US10280167, Example 31)
Show SMILES Nc1nc(nc2n(Cc3ccccc3)c(=O)[nH]c12)-c1nc(c[nH]1)C(F)(F)F
Show InChI InChI=1S/C16H12F3N7O/c17-16(18,19)9-6-21-12(22-9)13-24-11(20)10-14(25-13)26(15(27)23-10)7-8-4-2-1-3-5-8/h1-6H,7H2,(H,21,22)(H,23,27)(H2,20,24,25)
PDB

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n/an/an/an/a 1.30E+3n/an/an/an/a



University of Nottingham



Assay Description
Activation of human TLR7 results in robust production of interferon by plasmacytoid dendritic cells present in human blood. The potential of compound...

Br J Pharmacol 144: 317-22 (2005)


BindingDB Entry DOI: 10.7270/Q2Z60RDV
More data for this
Ligand-Target Pair
RNA-directed RNA polymerase


(Hepatitis C virus)		BDBM384110
PNG
(US10280167, Example 55)
Show SMILES Nc1nc(nc2n(Cc3cccc(c3)C(=O)N3CCCC3)c(=O)[nH]c12)-c1nnc[nH]1
Show InChI InChI=1S/C19H19N9O2/c20-14-13-17(25-16(24-14)15-21-10-22-26-15)28(19(30)23-13)9-11-4-3-5-12(8-11)18(29)27-6-1-2-7-27/h3-5,8,10H,1-2,6-7,9H2,(H,23,30)(H2,20,24,25)(H,21,22,26)
PDB

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Assay Description
Activation of human TLR7 results in robust production of interferon by plasmacytoid dendritic cells present in human blood. The potential of compound...

Br J Pharmacol 144: 317-22 (2005)


BindingDB Entry DOI: 10.7270/Q2Z60RDV
More data for this
Ligand-Target Pair
RNA-directed RNA polymerase


(Hepatitis C virus)		BDBM384116
PNG
(US10280167, Example 63)
Show SMILES Nc1nc(nc2n(CC3CCOCC3)c(=O)[nH]c12)-c1ncc[nH]1
Show InChI InChI=1S/C14H17N7O2/c15-10-9-13(20-12(19-10)11-16-3-4-17-11)21(14(22)18-9)7-8-1-5-23-6-2-8/h3-4,8H,1-2,5-7H2,(H,16,17)(H,18,22)(H2,15,19,20)
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Assay Description
Activation of human TLR7 results in robust production of interferon by plasmacytoid dendritic cells present in human blood. The potential of compound...

Br J Pharmacol 144: 317-22 (2005)


BindingDB Entry DOI: 10.7270/Q2Z60RDV
More data for this
Ligand-Target Pair
RNA-directed RNA polymerase


(Hepatitis C virus)		BDBM384079
PNG
(US10280167, Example 2)
Show SMILES Nc1nc(nc2n(Cc3ccccc3)c(=O)[nH]c12)-c1nc(c[nH]1)-c1ccccc1
Show InChI InChI=1S/C21H17N7O/c22-17-16-20(28(21(29)25-16)12-13-7-3-1-4-8-13)27-19(26-17)18-23-11-15(24-18)14-9-5-2-6-10-14/h1-11H,12H2,(H,23,24)(H,25,29)(H2,22,26,27)
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Assay Description
Activation of human TLR7 results in robust production of interferon by plasmacytoid dendritic cells present in human blood. The potential of compound...

Br J Pharmacol 144: 317-22 (2005)


BindingDB Entry DOI: 10.7270/Q2Z60RDV
More data for this
Ligand-Target Pair
RNA-directed RNA polymerase


(Hepatitis C virus)		BDBM384092
PNG
(US10280167, Example 19)
Show SMILES Nc1nc(nc2n(Cc3ccccc3)c(=O)[nH]c12)-c1cn[nH]c1
Show InChI InChI=1S/C15H13N7O/c16-12-11-14(21-13(20-12)10-6-17-18-7-10)22(15(23)19-11)8-9-4-2-1-3-5-9/h1-7H,8H2,(H,17,18)(H,19,23)(H2,16,20,21)
PDB

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Assay Description
Activation of human TLR7 results in robust production of interferon by plasmacytoid dendritic cells present in human blood. The potential of compound...

Br J Pharmacol 144: 317-22 (2005)


BindingDB Entry DOI: 10.7270/Q2Z60RDV
More data for this
Ligand-Target Pair
RNA-directed RNA polymerase


(Hepatitis C virus)		BDBM384107
PNG
(US10280167, Example 36)
Show SMILES Nc1nc(nc2n(Cc3ccccc3)c(=O)[nH]c12)-n1cccn1
Show InChI InChI=1S/C15H13N7O/c16-12-11-13(20-14(19-12)22-8-4-7-17-22)21(15(23)18-11)9-10-5-2-1-3-6-10/h1-8H,9H2,(H,18,23)(H2,16,19,20)
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Assay Description
Activation of human TLR7 results in robust production of interferon by plasmacytoid dendritic cells present in human blood. The potential of compound...

Br J Pharmacol 144: 317-22 (2005)


BindingDB Entry DOI: 10.7270/Q2Z60RDV
More data for this
Ligand-Target Pair
RNA-directed RNA polymerase


(Hepatitis C virus)		BDBM384094
PNG
(US10280167, Example 23)
Show SMILES Nc1nc(nc2n(Cc3ccccc3)c(=O)[nH]c12)-c1ccn[nH]1
Show InChI InChI=1S/C15H13N7O/c16-12-11-14(20-13(19-12)10-6-7-17-21-10)22(15(23)18-11)8-9-4-2-1-3-5-9/h1-7H,8H2,(H,17,21)(H,18,23)(H2,16,19,20)
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Assay Description
Activation of human TLR7 results in robust production of interferon by plasmacytoid dendritic cells present in human blood. The potential of compound...

Br J Pharmacol 144: 317-22 (2005)


BindingDB Entry DOI: 10.7270/Q2Z60RDV
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%