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USPatent US9150519

Compile Data Set for Download or QSAR

Found 242 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Sphingosine 1-phosphate receptor 1


(Homo sapiens (Human))		BDBM50313357
PNG
(3-(4-(6-(cyclohexyl(cyclopropylmethyl)amino)pyrimi...)
Show SMILES Cc1cc(ccc1NC(=O)c1cc(ncn1)N(CC1CC1)C1CCCCC1)S(=O)(=O)NCCC(O)=O
Show InChI InChI=1S/C25H33N5O5S/c1-17-13-20(36(34,35)28-12-11-24(31)32)9-10-21(17)29-25(33)22-14-23(27-16-26-22)30(15-18-7-8-18)19-5-3-2-4-6-19/h9-10,13-14,16,18-19,28H,2-8,11-12,15H2,1H3,(H,29,33)(H,31,32)
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US Patent
 2 -46.2n/an/an/an/an/a7.44



MERCK SERONO SA

US Patent


Assay Description
Membranes were prepared from CHO cells expressing S1P1 or S1P3 for use in ligand and 35S-GTPgammaS binding studies. Cells were suspended in 50 mM TRI...

US Patent US9150519 (2015)


BindingDB Entry DOI: 10.7270/Q2H993ZK
More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 1


(Homo sapiens (Human))		BDBM50313351
PNG
(6-(dipropylamino)-N-(1H-indazol-5-yl)pyrimidine-4-...)
Show SMILES CCCN(CCC)c1cc(ncn1)C(=O)Nc1ccc2[nH]ncc2c1
Show InChI InChI=1S/C18H22N6O/c1-3-7-24(8-4-2)17-10-16(19-12-20-17)18(25)22-14-5-6-15-13(9-14)11-21-23-15/h5-6,9-12H,3-4,7-8H2,1-2H3,(H,21,23)(H,22,25)
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US Patent
 3 -45.2n/an/an/an/an/a7.44



MERCK SERONO SA

US Patent


Assay Description
Membranes were prepared from CHO cells expressing S1P1 or S1P3 for use in ligand and 35S-GTPgammaS binding studies. Cells were suspended in 50 mM TRI...

US Patent US9150519 (2015)


BindingDB Entry DOI: 10.7270/Q2H993ZK
More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 1


(Homo sapiens (Human))		BDBM183667
PNG
(US9150519, 1-55)
Show SMILES COCCN(C1CCCCC1)c1cc(ncn1)C(=O)Nc1ccc(cc1C)S(N)(=O)=O
Show InChI InChI=1S/C21H29N5O4S/c1-15-12-17(31(22,28)29)8-9-18(15)25-21(27)19-13-20(24-14-23-19)26(10-11-30-2)16-6-4-3-5-7-16/h8-9,12-14,16H,3-7,10-11H2,1-2H3,(H,25,27)(H2,22,28,29)
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US Patent
 3.20 -45.1n/an/an/an/an/a7.44



MERCK SERONO SA

US Patent


Assay Description
Membranes were prepared from CHO cells expressing S1P1 or S1P3 for use in ligand and 35S-GTPgammaS binding studies. Cells were suspended in 50 mM TRI...

US Patent US9150519 (2015)


BindingDB Entry DOI: 10.7270/Q2H993ZK
More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 1


(Homo sapiens (Human))		BDBM50313358
PNG
(3-(4-(6-((cyclopropylmethyl)(propyl)amino)pyrimidi...)
Show SMILES CCCN(CC1CC1)c1cc(ncn1)C(=O)Nc1ccc(cc1C)S(=O)(=O)NCCC(O)=O
Show InChI InChI=1S/C22H29N5O5S/c1-3-10-27(13-16-4-5-16)20-12-19(23-14-24-20)22(30)26-18-7-6-17(11-15(18)2)33(31,32)25-9-8-21(28)29/h6-7,11-12,14,16,25H,3-5,8-10,13H2,1-2H3,(H,26,30)(H,28,29)
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US Patent
 6 -43.6n/an/an/an/an/a7.44



MERCK SERONO SA

US Patent


Assay Description
Membranes were prepared from CHO cells expressing S1P1 or S1P3 for use in ligand and 35S-GTPgammaS binding studies. Cells were suspended in 50 mM TRI...

US Patent US9150519 (2015)


BindingDB Entry DOI: 10.7270/Q2H993ZK
More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 1


(Homo sapiens (Human))		BDBM183668
PNG
(US9150519, 1-56)
Show SMILES CCCN(CC1CC1)c1cc(ncn1)C(=O)Nc1ccc(cc1C)S(N)(=O)=O
Show InChI InChI=1S/C19H25N5O3S/c1-3-8-24(11-14-4-5-14)18-10-17(21-12-22-18)19(25)23-16-7-6-15(9-13(16)2)28(20,26)27/h6-7,9-10,12,14H,3-5,8,11H2,1-2H3,(H,23,25)(H2,20,26,27)
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US Patent
 7 -43.3n/an/an/an/an/a7.44



MERCK SERONO SA

US Patent


Assay Description
Membranes were prepared from CHO cells expressing S1P1 or S1P3 for use in ligand and 35S-GTPgammaS binding studies. Cells were suspended in 50 mM TRI...

US Patent US9150519 (2015)


BindingDB Entry DOI: 10.7270/Q2H993ZK
More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 1


(Homo sapiens (Human))		BDBM183686
PNG
(US9150519, 1-84)
Show SMILES OC(=O)C1CN(Cc2ccc(NC(=O)c3cc(ncn3)N(CC3CC3)C3CCCCC3)cc2)C1
Show InChI InChI=1S/C26H33N5O3/c32-25(29-21-10-8-18(9-11-21)13-30-15-20(16-30)26(33)34)23-12-24(28-17-27-23)31(14-19-6-7-19)22-4-2-1-3-5-22/h8-12,17,19-20,22H,1-7,13-16H2,(H,29,32)(H,33,34)
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US Patent
 7 -43.3n/an/an/an/an/a7.44



MERCK SERONO SA

US Patent


Assay Description
Membranes were prepared from CHO cells expressing S1P1 or S1P3 for use in ligand and 35S-GTPgammaS binding studies. Cells were suspended in 50 mM TRI...

US Patent US9150519 (2015)


BindingDB Entry DOI: 10.7270/Q2H993ZK
More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 1


(Homo sapiens (Human))		BDBM183701
PNG
(US9150519, 1-100)
Show SMILES CCCN(CC1CC1)c1cc(ncn1)C(=O)Nc1ccc(CNCC(O)=O)cc1C
Show InChI InChI=1S/C22H29N5O3/c1-3-8-27(13-16-4-5-16)20-10-19(24-14-25-20)22(30)26-18-7-6-17(9-15(18)2)11-23-12-21(28)29/h6-7,9-10,14,16,23H,3-5,8,11-13H2,1-2H3,(H,26,30)(H,28,29)
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US Patent
 8 -43.0n/an/an/an/an/a7.44



MERCK SERONO SA

US Patent


Assay Description
Membranes were prepared from CHO cells expressing S1P1 or S1P3 for use in ligand and 35S-GTPgammaS binding studies. Cells were suspended in 50 mM TRI...

US Patent US9150519 (2015)


BindingDB Entry DOI: 10.7270/Q2H993ZK
More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 1


(Homo sapiens (Human))		BDBM50313359
PNG
(4-(4-(6-(cyclohexyl(cyclopropylmethyl)amino)pyrimi...)
Show SMILES Cc1cc(ccc1NC(=O)c1cc(ncn1)N(CC1CC1)C1CCCCC1)S(=O)(=O)NCCCC(O)=O
Show InChI InChI=1S/C26H35N5O5S/c1-18-14-21(37(35,36)29-13-5-8-25(32)33)11-12-22(18)30-26(34)23-15-24(28-17-27-23)31(16-19-9-10-19)20-6-3-2-4-7-20/h11-12,14-15,17,19-20,29H,2-10,13,16H2,1H3,(H,30,34)(H,32,33)
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US Patent
 8 -43.0n/an/an/an/an/a7.44



MERCK SERONO SA

US Patent


Assay Description
Membranes were prepared from CHO cells expressing S1P1 or S1P3 for use in ligand and 35S-GTPgammaS binding studies. Cells were suspended in 50 mM TRI...

US Patent US9150519 (2015)


BindingDB Entry DOI: 10.7270/Q2H993ZK
More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 1


(Homo sapiens (Human))		BDBM183699
PNG
(US9150519, 1-97)
Show SMILES CCCN(CC1CC1)c1cc(ncn1)C(=O)Nc1ccc(CNCCC(O)=O)cc1C
Show InChI InChI=1S/C23H31N5O3/c1-3-10-28(14-17-4-5-17)21-12-20(25-15-26-21)23(31)27-19-7-6-18(11-16(19)2)13-24-9-8-22(29)30/h6-7,11-12,15,17,24H,3-5,8-10,13-14H2,1-2H3,(H,27,31)(H,29,30)
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US Patent
 9 -42.7n/an/an/an/an/a7.44



MERCK SERONO SA

US Patent


Assay Description
Membranes were prepared from CHO cells expressing S1P1 or S1P3 for use in ligand and 35S-GTPgammaS binding studies. Cells were suspended in 50 mM TRI...

US Patent US9150519 (2015)


BindingDB Entry DOI: 10.7270/Q2H993ZK
More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 1


(Homo sapiens (Human))		BDBM50313363
PNG
(3-(4-(6-(cyclohexyl(cyclopropylmethyl)amino)pyrimi...)
Show SMILES OC(=O)CCNCc1ccc(NC(=O)c2cc(ncn2)N(CC2CC2)C2CCCCC2)cc1
Show InChI InChI=1S/C25H33N5O3/c31-24(32)12-13-26-15-18-8-10-20(11-9-18)29-25(33)22-14-23(28-17-27-22)30(16-19-6-7-19)21-4-2-1-3-5-21/h8-11,14,17,19,21,26H,1-7,12-13,15-16H2,(H,29,33)(H,31,32)
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US Patent
 9 -42.7n/an/an/an/an/a7.44



MERCK SERONO SA

US Patent


Assay Description
Membranes were prepared from CHO cells expressing S1P1 or S1P3 for use in ligand and 35S-GTPgammaS binding studies. Cells were suspended in 50 mM TRI...

US Patent US9150519 (2015)


BindingDB Entry DOI: 10.7270/Q2H993ZK
More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 1


(Homo sapiens (Human))		BDBM183676
PNG
(US9150519, 1-69)
Show SMILES CC(C)CN(C1CCCC1)c1cc(ncn1)C(=O)Nc1ccc2[nH]ncc2c1
Show InChI InChI=1S/C21H26N6O/c1-14(2)12-27(17-5-3-4-6-17)20-10-19(22-13-23-20)21(28)25-16-7-8-18-15(9-16)11-24-26-18/h7-11,13-14,17H,3-6,12H2,1-2H3,(H,24,26)(H,25,28)
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US Patent
 10 -42.4n/an/an/an/an/a7.44



MERCK SERONO SA

US Patent


Assay Description
Membranes were prepared from CHO cells expressing S1P1 or S1P3 for use in ligand and 35S-GTPgammaS binding studies. Cells were suspended in 50 mM TRI...

US Patent US9150519 (2015)


BindingDB Entry DOI: 10.7270/Q2H993ZK
More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 1


(Homo sapiens (Human))		BDBM50313361
PNG
(2-(4-(6-(cyclohexyl(cyclopropylmethyl)amino)pyrimi...)
Show SMILES OC(=O)CNCc1ccc(NC(=O)c2cc(ncn2)N(CC2CC2)C2CCCCC2)cc1
Show InChI InChI=1S/C24H31N5O3/c30-23(31)14-25-13-17-8-10-19(11-9-17)28-24(32)21-12-22(27-16-26-21)29(15-18-6-7-18)20-4-2-1-3-5-20/h8-12,16,18,20,25H,1-7,13-15H2,(H,28,32)(H,30,31)
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US Patent
 12 -42.0n/an/an/an/an/a7.44



MERCK SERONO SA

US Patent


Assay Description
Membranes were prepared from CHO cells expressing S1P1 or S1P3 for use in ligand and 35S-GTPgammaS binding studies. Cells were suspended in 50 mM TRI...

US Patent US9150519 (2015)


BindingDB Entry DOI: 10.7270/Q2H993ZK
More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 1


(Homo sapiens (Human))		BDBM183692
PNG
(US9150519, 1-90)
Show SMILES COCCN(CC1CC1)c1cc(ncn1)C(=O)Nc1ccc2[nH]ncc2c1
Show InChI InChI=1S/C19H22N6O2/c1-27-7-6-25(11-13-2-3-13)18-9-17(20-12-21-18)19(26)23-15-4-5-16-14(8-15)10-22-24-16/h4-5,8-10,12-13H,2-3,6-7,11H2,1H3,(H,22,24)(H,23,26)
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US Patent
 23 -40.5n/an/an/an/an/a7.44



MERCK SERONO SA

US Patent


Assay Description
Membranes were prepared from CHO cells expressing S1P1 or S1P3 for use in ligand and 35S-GTPgammaS binding studies. Cells were suspended in 50 mM TRI...

US Patent US9150519 (2015)


BindingDB Entry DOI: 10.7270/Q2H993ZK
More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 1


(Homo sapiens (Human))		BDBM183710
PNG
(US9150519, 1-113)
Show SMILES CCCN(CC1CC1)c1cc(ncn1)C(=O)Nc1cccc2[nH]ccc12
Show InChI InChI=1S/C20H23N5O/c1-2-10-25(12-14-6-7-14)19-11-18(22-13-23-19)20(26)24-17-5-3-4-16-15(17)8-9-21-16/h3-5,8-9,11,13-14,21H,2,6-7,10,12H2,1H3,(H,24,26)
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US Patent
 25 -40.3n/an/an/an/an/a7.44



MERCK SERONO SA

US Patent


Assay Description
Membranes were prepared from CHO cells expressing S1P1 or S1P3 for use in ligand and 35S-GTPgammaS binding studies. Cells were suspended in 50 mM TRI...

US Patent US9150519 (2015)


BindingDB Entry DOI: 10.7270/Q2H993ZK
More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 1


(Homo sapiens (Human))		BDBM50313362
PNG
(2-((4-(6-(cyclohexyl(cyclopropylmethyl)amino)pyrim...)
Show SMILES CN(CC(O)=O)Cc1ccc(NC(=O)c2cc(ncn2)N(CC2CC2)C2CCCCC2)cc1
Show InChI InChI=1S/C25H33N5O3/c1-29(16-24(31)32)14-18-9-11-20(12-10-18)28-25(33)22-13-23(27-17-26-22)30(15-19-7-8-19)21-5-3-2-4-6-21/h9-13,17,19,21H,2-8,14-16H2,1H3,(H,28,33)(H,31,32)
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US Patent
 29 -40.0n/an/an/an/an/a7.44



MERCK SERONO SA

US Patent


Assay Description
Membranes were prepared from CHO cells expressing S1P1 or S1P3 for use in ligand and 35S-GTPgammaS binding studies. Cells were suspended in 50 mM TRI...

US Patent US9150519 (2015)


BindingDB Entry DOI: 10.7270/Q2H993ZK
More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 1


(Homo sapiens (Human))		BDBM183687
PNG
(US9150519, 1-85)
Show SMILES CCCN(CC1CC1)c1cc(ncn1)C(=O)Nc1ccc(CO)cc1C
Show InChI InChI=1S/C20H26N4O2/c1-3-8-24(11-15-4-5-15)19-10-18(21-13-22-19)20(26)23-17-7-6-16(12-25)9-14(17)2/h6-7,9-10,13,15,25H,3-5,8,11-12H2,1-2H3,(H,23,26)
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US Patent
 43 -39.1n/an/an/an/an/a7.44



MERCK SERONO SA

US Patent


Assay Description
Membranes were prepared from CHO cells expressing S1P1 or S1P3 for use in ligand and 35S-GTPgammaS binding studies. Cells were suspended in 50 mM TRI...

US Patent US9150519 (2015)


BindingDB Entry DOI: 10.7270/Q2H993ZK
More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 1


(Homo sapiens (Human))		BDBM50313345
PNG
(6-(cyclohexyl(cyclopropylmethyl)amino)-N-(4-((dime...)
Show SMILES CN(C)Cc1ccc(NC(=O)c2cc(ncn2)N(CC2CC2)C2CCCCC2)cc1
Show InChI InChI=1S/C24H33N5O/c1-28(2)15-18-10-12-20(13-11-18)27-24(30)22-14-23(26-17-25-22)29(16-19-8-9-19)21-6-4-3-5-7-21/h10-14,17,19,21H,3-9,15-16H2,1-2H3,(H,27,30)
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 51 -38.7n/an/an/an/an/a7.44



MERCK SERONO SA

US Patent


Assay Description
Membranes were prepared from CHO cells expressing S1P1 or S1P3 for use in ligand and 35S-GTPgammaS binding studies. Cells were suspended in 50 mM TRI...

US Patent US9150519 (2015)


BindingDB Entry DOI: 10.7270/Q2H993ZK
More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 1


(Homo sapiens (Human))		BDBM50313333
PNG
(6-(cyclohexylamino)-N-(4-(methylsulfonamido)phenyl...)
Show SMILES CS(=O)(=O)Nc1ccc(NC(=O)c2cc(NC3CCCCC3)ncn2)cc1
Show InChI InChI=1S/C18H23N5O3S/c1-27(25,26)23-15-9-7-14(8-10-15)22-18(24)16-11-17(20-12-19-16)21-13-5-3-2-4-6-13/h7-13,23H,2-6H2,1H3,(H,22,24)(H,19,20,21)
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US Patent
 280 -34.8n/an/an/an/an/a7.44



MERCK SERONO SA

US Patent


Assay Description
Membranes were prepared from CHO cells expressing S1P1 or S1P3 for use in ligand and 35S-GTPgammaS binding studies. Cells were suspended in 50 mM TRI...

US Patent US9150519 (2015)


BindingDB Entry DOI: 10.7270/Q2H993ZK
More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 1


(Homo sapiens (Human))		BDBM50313326
PNG
(6-(cyclohexylamino)-N-(2-fluoro-4-hydroxyphenyl)py...)
Show SMILES Oc1ccc(NC(=O)c2cc(NC3CCCCC3)ncn2)c(F)c1
Show InChI InChI=1S/C17H19FN4O2/c18-13-8-12(23)6-7-14(13)22-17(24)15-9-16(20-10-19-15)21-11-4-2-1-3-5-11/h6-11,23H,1-5H2,(H,22,24)(H,19,20,21)
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US Patent
 340 -34.3n/an/an/an/an/a7.44



MERCK SERONO SA

US Patent


Assay Description
Membranes were prepared from CHO cells expressing S1P1 or S1P3 for use in ligand and 35S-GTPgammaS binding studies. Cells were suspended in 50 mM TRI...

US Patent US9150519 (2015)


BindingDB Entry DOI: 10.7270/Q2H993ZK
More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 1


(Homo sapiens (Human))		BDBM50313327
PNG
(CHEMBL1076723 | N-(2-chloro-4-hydroxyphenyl)-6-(cy...)
Show SMILES Oc1ccc(NC(=O)c2cc(NC3CCCCC3)ncn2)c(Cl)c1
Show InChI InChI=1S/C17H19ClN4O2/c18-13-8-12(23)6-7-14(13)22-17(24)15-9-16(20-10-19-15)21-11-4-2-1-3-5-11/h6-11,23H,1-5H2,(H,22,24)(H,19,20,21)
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US Patent
 380 -34.1n/an/an/an/an/a7.44



MERCK SERONO SA

US Patent


Assay Description
Membranes were prepared from CHO cells expressing S1P1 or S1P3 for use in ligand and 35S-GTPgammaS binding studies. Cells were suspended in 50 mM TRI...

US Patent US9150519 (2015)


BindingDB Entry DOI: 10.7270/Q2H993ZK
More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 1


(Homo sapiens (Human))		BDBM50313346
PNG
(6-(cyclohexylamino)-N-(1H-indazol-5-yl)pyrimidine-...)
Show SMILES O=C(Nc1ccc2[nH]ncc2c1)c1cc(NC2CCCCC2)ncn1
Show InChI InChI=1S/C18H20N6O/c25-18(23-14-6-7-15-12(8-14)10-21-24-15)16-9-17(20-11-19-16)22-13-4-2-1-3-5-13/h6-11,13H,1-5H2,(H,21,24)(H,23,25)(H,19,20,22)
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US Patent
 458 -33.6n/an/an/an/an/a7.44



MERCK SERONO SA

US Patent


Assay Description
Membranes were prepared from CHO cells expressing S1P1 or S1P3 for use in ligand and 35S-GTPgammaS binding studies. Cells were suspended in 50 mM TRI...

US Patent US9150519 (2015)


BindingDB Entry DOI: 10.7270/Q2H993ZK
More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 1


(Homo sapiens (Human))		BDBM183644
PNG
(US9150519, 1-6)
Show SMILES Oc1ccc(NC(=O)c2cc(NC3CCCCC3)ncn2)cc1Cl
Show InChI InChI=1S/C17H19ClN4O2/c18-13-8-12(6-7-15(13)23)22-17(24)14-9-16(20-10-19-14)21-11-4-2-1-3-5-11/h6-11,23H,1-5H2,(H,22,24)(H,19,20,21)
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US Patent
 500 -33.4n/an/an/an/an/a7.44



MERCK SERONO SA

US Patent


Assay Description
Membranes were prepared from CHO cells expressing S1P1 or S1P3 for use in ligand and 35S-GTPgammaS binding studies. Cells were suspended in 50 mM TRI...

US Patent US9150519 (2015)


BindingDB Entry DOI: 10.7270/Q2H993ZK
More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 1


(Homo sapiens (Human))		BDBM183643
PNG
(US9150519, 1-5)
Show SMILES Oc1ccc(NC(=O)c2cc(NC3CCCCC3)ncn2)c2ccccc12
Show InChI InChI=1S/C21H22N4O2/c26-19-11-10-17(15-8-4-5-9-16(15)19)25-21(27)18-12-20(23-13-22-18)24-14-6-2-1-3-7-14/h4-5,8-14,26H,1-3,6-7H2,(H,25,27)(H,22,23,24)
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US Patent
 540 -33.3n/an/an/an/an/a7.44



MERCK SERONO SA

US Patent


Assay Description
Membranes were prepared from CHO cells expressing S1P1 or S1P3 for use in ligand and 35S-GTPgammaS binding studies. Cells were suspended in 50 mM TRI...

US Patent US9150519 (2015)


BindingDB Entry DOI: 10.7270/Q2H993ZK
More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 1


(Homo sapiens (Human))		BDBM50313325
PNG
(6-(Cyclohexylamino)-N-(4-hydroxy-2-methylphenyl)py...)
Show SMILES Cc1cc(O)ccc1NC(=O)c1cc(NC2CCCCC2)ncn1
Show InChI InChI=1S/C18H22N4O2/c1-12-9-14(23)7-8-15(12)22-18(24)16-10-17(20-11-19-16)21-13-5-3-2-4-6-13/h7-11,13,23H,2-6H2,1H3,(H,22,24)(H,19,20,21)
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US Patent
 550 -33.2n/an/an/an/an/a7.44



MERCK SERONO SA

US Patent


Assay Description
Membranes were prepared from CHO cells expressing S1P1 or S1P3 for use in ligand and 35S-GTPgammaS binding studies. Cells were suspended in 50 mM TRI...

US Patent US9150519 (2015)


BindingDB Entry DOI: 10.7270/Q2H993ZK
More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 1


(Homo sapiens (Human))		BDBM183645
PNG
(US9150519, 1-9)
Show SMILES Cc1c(O)ccc(NC(=O)c2cc(NC3CCCCC3)ncn2)c1C
Show InChI InChI=1S/C19H24N4O2/c1-12-13(2)17(24)9-8-15(12)23-19(25)16-10-18(21-11-20-16)22-14-6-4-3-5-7-14/h8-11,14,24H,3-7H2,1-2H3,(H,23,25)(H,20,21,22)
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US Patent
 650 -32.8n/an/an/an/an/a7.44



MERCK SERONO SA

US Patent


Assay Description
Membranes were prepared from CHO cells expressing S1P1 or S1P3 for use in ligand and 35S-GTPgammaS binding studies. Cells were suspended in 50 mM TRI...

US Patent US9150519 (2015)


BindingDB Entry DOI: 10.7270/Q2H993ZK
More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 1


(Homo sapiens (Human))		BDBM183646
PNG
(US9150519, 1-10)
Show SMILES Cc1cc(NC(=O)c2cc(NC3CCCCC3)ncn2)c(C)cc1O
Show InChI InChI=1S/C19H24N4O2/c1-12-9-17(24)13(2)8-15(12)23-19(25)16-10-18(21-11-20-16)22-14-6-4-3-5-7-14/h8-11,14,24H,3-7H2,1-2H3,(H,23,25)(H,20,21,22)
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US Patent
 740 -32.5n/an/an/an/an/a7.44



MERCK SERONO SA

US Patent


Assay Description
Membranes were prepared from CHO cells expressing S1P1 or S1P3 for use in ligand and 35S-GTPgammaS binding studies. Cells were suspended in 50 mM TRI...

US Patent US9150519 (2015)


BindingDB Entry DOI: 10.7270/Q2H993ZK
More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 1


(Homo sapiens (Human))		BDBM50313320
PNG
(6-(cyclohexyl(methyl)amino)-N-(4-hydroxyphenyl)pyr...)
Show SMILES CN(C1CCCCC1)c1cc(ncn1)C(=O)Nc1ccc(O)cc1
Show InChI InChI=1S/C18H22N4O2/c1-22(14-5-3-2-4-6-14)17-11-16(19-12-20-17)18(24)21-13-7-9-15(23)10-8-13/h7-12,14,23H,2-6H2,1H3,(H,21,24)
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US Patent
 810 -32.3n/an/an/an/an/a7.44



MERCK SERONO SA

US Patent


Assay Description
Membranes were prepared from CHO cells expressing S1P1 or S1P3 for use in ligand and 35S-GTPgammaS binding studies. Cells were suspended in 50 mM TRI...

US Patent US9150519 (2015)


BindingDB Entry DOI: 10.7270/Q2H993ZK
More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 1


(Homo sapiens (Human))		BDBM50313318
PNG
(CHEMBL1081268 | N-(4-hydroxyphenyl)-6-(o-tolylamin...)
Show SMILES Cc1ccccc1Nc1cc(ncn1)C(=O)Nc1ccc(O)cc1
Show InChI InChI=1S/C18H16N4O2/c1-12-4-2-3-5-15(12)22-17-10-16(19-11-20-17)18(24)21-13-6-8-14(23)9-7-13/h2-11,23H,1H3,(H,21,24)(H,19,20,22)
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US Patent
 840 -32.2n/an/an/an/an/a7.44



MERCK SERONO SA

US Patent


Assay Description
Membranes were prepared from CHO cells expressing S1P1 or S1P3 for use in ligand and 35S-GTPgammaS binding studies. Cells were suspended in 50 mM TRI...

US Patent US9150519 (2015)


BindingDB Entry DOI: 10.7270/Q2H993ZK
More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 1


(Homo sapiens (Human))		BDBM183642
PNG
(US9150519, 1-4)
Show SMILES Cc1cc(NC(=O)c2cc(NC3CCCCC3)ncn2)ccc1O
Show InChI InChI=1S/C18H22N4O2/c1-12-9-14(7-8-16(12)23)22-18(24)15-10-17(20-11-19-15)21-13-5-3-2-4-6-13/h7-11,13,23H,2-6H2,1H3,(H,22,24)(H,19,20,21)
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US Patent
 980 -31.9n/an/an/an/an/a7.44



MERCK SERONO SA

US Patent


Assay Description
Membranes were prepared from CHO cells expressing S1P1 or S1P3 for use in ligand and 35S-GTPgammaS binding studies. Cells were suspended in 50 mM TRI...

US Patent US9150519 (2015)


BindingDB Entry DOI: 10.7270/Q2H993ZK
More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 1


(Homo sapiens (Human))		BDBM183672
PNG
(US9150519, 1-64)
Show SMILES CN(C)S(=O)(=O)c1ccc(NC(=O)c2cc(ncn2)N(CC2CC2)C2CCCCC2)c(C)c1
Show InChI InChI=1S/C24H33N5O3S/c1-17-13-20(33(31,32)28(2)3)11-12-21(17)27-24(30)22-14-23(26-16-25-22)29(15-18-9-10-18)19-7-5-4-6-8-19/h11-14,16,18-19H,4-10,15H2,1-3H3,(H,27,30)
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US Patent
 1.02E+3 -31.8n/an/an/an/an/a7.44



MERCK SERONO SA

US Patent


Assay Description
Membranes were prepared from CHO cells expressing S1P1 or S1P3 for use in ligand and 35S-GTPgammaS binding studies. Cells were suspended in 50 mM TRI...

US Patent US9150519 (2015)


BindingDB Entry DOI: 10.7270/Q2H993ZK
More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 1


(Homo sapiens (Human))		BDBM50313313
PNG
(6-(cyclohexylamino)-N-(4-hydroxyphenyl)pyrimidine-...)
Show SMILES Oc1ccc(NC(=O)c2cc(NC3CCCCC3)ncn2)cc1
Show InChI InChI=1S/C17H20N4O2/c22-14-8-6-13(7-9-14)21-17(23)15-10-16(19-11-18-15)20-12-4-2-1-3-5-12/h6-12,22H,1-5H2,(H,21,23)(H,18,19,20)
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US Patent
 1.68E+3 -30.6n/an/an/an/an/a7.44



MERCK SERONO SA

US Patent


Assay Description
Membranes were prepared from CHO cells expressing S1P1 or S1P3 for use in ligand and 35S-GTPgammaS binding studies. Cells were suspended in 50 mM TRI...

US Patent US9150519 (2015)


BindingDB Entry DOI: 10.7270/Q2H993ZK
More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 1


(Homo sapiens (Human))		BDBM50313330
PNG
(6-(cyclohexylamino)-N-(4-(2-hydroxyethyl)phenyl)py...)
Show SMILES OCCc1ccc(NC(=O)c2cc(NC3CCCCC3)ncn2)cc1
Show InChI InChI=1S/C19H24N4O2/c24-11-10-14-6-8-16(9-7-14)23-19(25)17-12-18(21-13-20-17)22-15-4-2-1-3-5-15/h6-9,12-13,15,24H,1-5,10-11H2,(H,23,25)(H,20,21,22)
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US Patent
 2.00E+3 -30.2n/an/an/an/an/a7.44



MERCK SERONO SA

US Patent


Assay Description
Membranes were prepared from CHO cells expressing S1P1 or S1P3 for use in ligand and 35S-GTPgammaS binding studies. Cells were suspended in 50 mM TRI...

US Patent US9150519 (2015)


BindingDB Entry DOI: 10.7270/Q2H993ZK
More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 1


(Homo sapiens (Human))		BDBM50313316
PNG
(6-(cyclopentylamino)-N-(4-hydroxyphenyl)pyrimidine...)
Show SMILES Oc1ccc(NC(=O)c2cc(NC3CCCC3)ncn2)cc1
Show InChI InChI=1S/C16H18N4O2/c21-13-7-5-12(6-8-13)20-16(22)14-9-15(18-10-17-14)19-11-3-1-2-4-11/h5-11,21H,1-4H2,(H,20,22)(H,17,18,19)
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US Patent
 2.13E+3 -30.1n/an/an/an/an/a7.44



MERCK SERONO SA

US Patent


Assay Description
Membranes were prepared from CHO cells expressing S1P1 or S1P3 for use in ligand and 35S-GTPgammaS binding studies. Cells were suspended in 50 mM TRI...

US Patent US9150519 (2015)


BindingDB Entry DOI: 10.7270/Q2H993ZK
More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 1


(Homo sapiens (Human))		BDBM183688
PNG
(US9150519, 1-86)
Show SMILES Cc1cc(ccc1NC(=O)c1cc(ncn1)N(CC1CC1)C1CCCCC1)S(=O)(=O)NCCC(=O)OC(C)(C)C
Show InChI InChI=1S/C29H41N5O5S/c1-20-16-23(40(37,38)32-15-14-27(35)39-29(2,3)4)12-13-24(20)33-28(36)25-17-26(31-19-30-25)34(18-21-10-11-21)22-8-6-5-7-9-22/h12-13,16-17,19,21-22,32H,5-11,14-15,18H2,1-4H3,(H,33,36)
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 2.46E+3 -29.8n/an/an/an/an/a7.44



MERCK SERONO SA

US Patent


Assay Description
Membranes were prepared from CHO cells expressing S1P1 or S1P3 for use in ligand and 35S-GTPgammaS binding studies. Cells were suspended in 50 mM TRI...

US Patent US9150519 (2015)


BindingDB Entry DOI: 10.7270/Q2H993ZK
More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 1


(Homo sapiens (Human))		BDBM183641
PNG
(US9150519, 1-2)
Show SMILES Oc1ccc(NC(=O)c2cc(NCC3CCCCC3)ncn2)cc1
Show InChI InChI=1S/C18H22N4O2/c23-15-8-6-14(7-9-15)22-18(24)16-10-17(21-12-20-16)19-11-13-4-2-1-3-5-13/h6-10,12-13,23H,1-5,11H2,(H,22,24)(H,19,20,21)
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US Patent
 3.23E+3 -29.1n/an/an/an/an/a7.44



MERCK SERONO SA

US Patent


Assay Description
Membranes were prepared from CHO cells expressing S1P1 or S1P3 for use in ligand and 35S-GTPgammaS binding studies. Cells were suspended in 50 mM TRI...

US Patent US9150519 (2015)


BindingDB Entry DOI: 10.7270/Q2H993ZK
More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 1


(Homo sapiens (Human))		BDBM183648
PNG
(US9150519, 1-12)
Show SMILES O=C(Nc1ccncc1)c1cc(NC2CCCCC2)ncn1
Show InChI InChI=1S/C16H19N5O/c22-16(21-13-6-8-17-9-7-13)14-10-15(19-11-18-14)20-12-4-2-1-3-5-12/h6-12H,1-5H2,(H,17,21,22)(H,18,19,20)
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 3.36E+3 -29.0n/an/an/an/an/a7.44



MERCK SERONO SA

US Patent


Assay Description
Membranes were prepared from CHO cells expressing S1P1 or S1P3 for use in ligand and 35S-GTPgammaS binding studies. Cells were suspended in 50 mM TRI...

US Patent US9150519 (2015)


BindingDB Entry DOI: 10.7270/Q2H993ZK
More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 1


(Homo sapiens (Human))		BDBM183647
PNG
(US9150519, 1-11)
Show SMILES Oc1c(Cl)cc(NC(=O)c2cc(NC3CCCCC3)ncn2)cc1Cl
Show InChI InChI=1S/C17H18Cl2N4O2/c18-12-6-11(7-13(19)16(12)24)23-17(25)14-8-15(21-9-20-14)22-10-4-2-1-3-5-10/h6-10,24H,1-5H2,(H,23,25)(H,20,21,22)
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 3.45E+3 -29.0n/an/an/an/an/a7.44



MERCK SERONO SA

US Patent


Assay Description
Membranes were prepared from CHO cells expressing S1P1 or S1P3 for use in ligand and 35S-GTPgammaS binding studies. Cells were suspended in 50 mM TRI...

US Patent US9150519 (2015)


BindingDB Entry DOI: 10.7270/Q2H993ZK
More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 1


(Homo sapiens (Human))		BDBM183645
PNG
(US9150519, 1-9)
Show SMILES Cc1c(O)ccc(NC(=O)c2cc(NC3CCCCC3)ncn2)c1C
Show InChI InChI=1S/C19H24N4O2/c1-12-13(2)17(24)9-8-15(12)23-19(25)16-10-18(21-11-20-16)22-14-6-4-3-5-7-14/h8-11,14,24H,3-7H2,1-2H3,(H,23,25)(H,20,21,22)
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n/an/an/an/a 1.04E+3n/an/a7.430



MERCK SERONO SA

US Patent


Assay Description
Measurements of 35S-GTPgammaS Binding: Membranes (1 to 10 µg protein) prepared as described above, were incubated in 96-well Scintiplates (PerkinElm...

US Patent US9150519 (2015)


BindingDB Entry DOI: 10.7270/Q2H993ZK
More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 1


(Homo sapiens (Human))		BDBM183646
PNG
(US9150519, 1-10)
Show SMILES Cc1cc(NC(=O)c2cc(NC3CCCCC3)ncn2)c(C)cc1O
Show InChI InChI=1S/C19H24N4O2/c1-12-9-17(24)13(2)8-15(12)23-19(25)16-10-18(21-11-20-16)22-14-6-4-3-5-7-14/h8-11,14,24H,3-7H2,1-2H3,(H,23,25)(H,20,21,22)
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n/an/an/an/a 1.44E+3n/an/a7.430



MERCK SERONO SA

US Patent


Assay Description
Measurements of 35S-GTPgammaS Binding: Membranes (1 to 10 µg protein) prepared as described above, were incubated in 96-well Scintiplates (PerkinElm...

US Patent US9150519 (2015)


BindingDB Entry DOI: 10.7270/Q2H993ZK
More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 1


(Homo sapiens (Human))		BDBM183653
PNG
(US9150519, 1-27)
Show SMILES COc1cc(NS(C)(=O)=O)ccc1NC(=O)c1cc(NC2CCCCC2)ncn1
Show InChI InChI=1S/C19H25N5O4S/c1-28-17-10-14(24-29(2,26)27)8-9-15(17)23-19(25)16-11-18(21-12-20-16)22-13-6-4-3-5-7-13/h8-13,24H,3-7H2,1-2H3,(H,23,25)(H,20,21,22)
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n/an/an/an/a 374n/an/a7.430



MERCK SERONO SA

US Patent


Assay Description
Measurements of 35S-GTPgammaS Binding: Membranes (1 to 10 µg protein) prepared as described above, were incubated in 96-well Scintiplates (PerkinElm...

US Patent US9150519 (2015)


BindingDB Entry DOI: 10.7270/Q2H993ZK
More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 1


(Homo sapiens (Human))		BDBM183662
PNG
(US9150519, 1-42)
Show SMILES COCCNS(=O)(=O)c1ccc(NC(=O)c2cc(ncn2)N(C)C2CCCCC2)cc1
Show InChI InChI=1S/C21H29N5O4S/c1-26(17-6-4-3-5-7-17)20-14-19(22-15-23-20)21(27)25-16-8-10-18(11-9-16)31(28,29)24-12-13-30-2/h8-11,14-15,17,24H,3-7,12-13H2,1-2H3,(H,25,27)
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n/an/an/an/a 2.28E+3n/an/a7.430



MERCK SERONO SA

US Patent


Assay Description
Measurements of 35S-GTPgammaS Binding: Membranes (1 to 10 µg protein) prepared as described above, were incubated in 96-well Scintiplates (PerkinElm...

US Patent US9150519 (2015)


BindingDB Entry DOI: 10.7270/Q2H993ZK
More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 1


(Homo sapiens (Human))		BDBM50313340
PNG
(6-(dipropylamino)-N-(2-methyl-4-sulfamoylphenyl)py...)
Show SMILES CCCN(CCC)c1cc(ncn1)C(=O)Nc1ccc(cc1C)S(N)(=O)=O
Show InChI InChI=1S/C18H25N5O3S/c1-4-8-23(9-5-2)17-11-16(20-12-21-17)18(24)22-15-7-6-14(10-13(15)3)27(19,25)26/h6-7,10-12H,4-5,8-9H2,1-3H3,(H,22,24)(H2,19,25,26)
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n/an/an/an/a 36n/an/a7.430



MERCK SERONO SA

US Patent


Assay Description
Measurements of 35S-GTPgammaS Binding: Membranes (1 to 10 µg protein) prepared as described above, were incubated in 96-well Scintiplates (PerkinElm...

US Patent US9150519 (2015)


BindingDB Entry DOI: 10.7270/Q2H993ZK
More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 1


(Homo sapiens (Human))		BDBM183671
PNG
(US9150519, 1-60)
Show SMILES CCCN(C(C)C)c1cc(ncn1)C(=O)Nc1ccc(cc1C)S(N)(=O)=O
Show InChI InChI=1S/C18H25N5O3S/c1-5-8-23(12(2)3)17-10-16(20-11-21-17)18(24)22-15-7-6-14(9-13(15)4)27(19,25)26/h6-7,9-12H,5,8H2,1-4H3,(H,22,24)(H2,19,25,26)
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n/an/an/an/a 51n/an/a7.430



MERCK SERONO SA

US Patent


Assay Description
Measurements of 35S-GTPgammaS Binding: Membranes (1 to 10 µg protein) prepared as described above, were incubated in 96-well Scintiplates (PerkinElm...

US Patent US9150519 (2015)


BindingDB Entry DOI: 10.7270/Q2H993ZK
More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 1


(Homo sapiens (Human))		BDBM183673
PNG
(US9150519, 1-65)
Show SMILES Cc1cc(ccc1NC(=O)c1cc(OC2CCCCC2)ncn1)S(N)(=O)=O
Show InChI InChI=1S/C18H22N4O4S/c1-12-9-14(27(19,24)25)7-8-15(12)22-18(23)16-10-17(21-11-20-16)26-13-5-3-2-4-6-13/h7-11,13H,2-6H2,1H3,(H,22,23)(H2,19,24,25)
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n/an/an/an/a 1.33E+4n/an/a7.430



MERCK SERONO SA

US Patent


Assay Description
Measurements of 35S-GTPgammaS Binding: Membranes (1 to 10 µg protein) prepared as described above, were incubated in 96-well Scintiplates (PerkinElm...

US Patent US9150519 (2015)


BindingDB Entry DOI: 10.7270/Q2H993ZK
More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 1


(Homo sapiens (Human))		BDBM183675
PNG
(US9150519, 1-67)
Show SMILES CCCN(C(C)C)c1cc(ncn1)C(=O)Nc1ccc2[nH]ncc2c1
Show InChI InChI=1S/C18H22N6O/c1-4-7-24(12(2)3)17-9-16(19-11-20-17)18(25)22-14-5-6-15-13(8-14)10-21-23-15/h5-6,8-12H,4,7H2,1-3H3,(H,21,23)(H,22,25)
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n/an/an/an/a 68n/an/a7.430



MERCK SERONO SA

US Patent


Assay Description
Measurements of 35S-GTPgammaS Binding: Membranes (1 to 10 µg protein) prepared as described above, were incubated in 96-well Scintiplates (PerkinElm...

US Patent US9150519 (2015)


BindingDB Entry DOI: 10.7270/Q2H993ZK
More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 1


(Homo sapiens (Human))		BDBM183676
PNG
(US9150519, 1-69)
Show SMILES CC(C)CN(C1CCCC1)c1cc(ncn1)C(=O)Nc1ccc2[nH]ncc2c1
Show InChI InChI=1S/C21H26N6O/c1-14(2)12-27(17-5-3-4-6-17)20-10-19(22-13-23-20)21(28)25-16-7-8-18-15(9-16)11-24-26-18/h7-11,13-14,17H,3-6,12H2,1-2H3,(H,24,26)(H,25,28)
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n/an/an/an/a 19n/an/a7.430



MERCK SERONO SA

US Patent


Assay Description
Measurements of 35S-GTPgammaS Binding: Membranes (1 to 10 µg protein) prepared as described above, were incubated in 96-well Scintiplates (PerkinElm...

US Patent US9150519 (2015)


BindingDB Entry DOI: 10.7270/Q2H993ZK
More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 1


(Homo sapiens (Human))		BDBM183682
PNG
(US9150519, 1-76)
Show SMILES COC(=O)CCNCc1ccc(NC(=O)c2cc(ncn2)N(CC2CC2)C2CCCCC2)cc1
Show InChI InChI=1S/C26H35N5O3/c1-34-25(32)13-14-27-16-19-9-11-21(12-10-19)30-26(33)23-15-24(29-18-28-23)31(17-20-7-8-20)22-5-3-2-4-6-22/h9-12,15,18,20,22,27H,2-8,13-14,16-17H2,1H3,(H,30,33)
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n/an/an/an/a 48n/an/a7.430



MERCK SERONO SA

US Patent


Assay Description
Measurements of 35S-GTPgammaS Binding: Membranes (1 to 10 µg protein) prepared as described above, were incubated in 96-well Scintiplates (PerkinElm...

US Patent US9150519 (2015)


BindingDB Entry DOI: 10.7270/Q2H993ZK
More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 1


(Homo sapiens (Human))		BDBM50313361
PNG
(2-(4-(6-(cyclohexyl(cyclopropylmethyl)amino)pyrimi...)
Show SMILES OC(=O)CNCc1ccc(NC(=O)c2cc(ncn2)N(CC2CC2)C2CCCCC2)cc1
Show InChI InChI=1S/C24H31N5O3/c30-23(31)14-25-13-17-8-10-19(11-9-17)28-24(32)21-12-22(27-16-26-21)29(15-18-6-7-18)20-4-2-1-3-5-20/h8-12,16,18,20,25H,1-7,13-15H2,(H,28,32)(H,30,31)
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n/an/an/an/a 35n/an/a7.430



MERCK SERONO SA

US Patent


Assay Description
Measurements of 35S-GTPgammaS Binding: Membranes (1 to 10 µg protein) prepared as described above, were incubated in 96-well Scintiplates (PerkinElm...

US Patent US9150519 (2015)


BindingDB Entry DOI: 10.7270/Q2H993ZK
More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 1


(Homo sapiens (Human))		BDBM183698
PNG
(US9150519, 1-96)
Show SMILES CCCN(CC1CC1)c1cc(ncn1)C(=O)Nc1ccc(CN(C)CCO)cc1C
Show InChI InChI=1S/C23H33N5O2/c1-4-9-28(15-18-5-6-18)22-13-21(24-16-25-22)23(30)26-20-8-7-19(12-17(20)2)14-27(3)10-11-29/h7-8,12-13,16,18,29H,4-6,9-11,14-15H2,1-3H3,(H,26,30)
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n/an/an/an/a 391n/an/a7.430



MERCK SERONO SA

US Patent


Assay Description
Measurements of 35S-GTPgammaS Binding: Membranes (1 to 10 µg protein) prepared as described above, were incubated in 96-well Scintiplates (PerkinElm...

US Patent US9150519 (2015)


BindingDB Entry DOI: 10.7270/Q2H993ZK
More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 1


(Homo sapiens (Human))		BDBM183703
PNG
(US9150519, 1-102)
Show SMILES CCCN(CC1CC1)c1cc(ncn1)C(=O)Nc1ccc(cc1C)S(=O)(=O)N(C)CC(O)=O
Show InChI InChI=1S/C22H29N5O5S/c1-4-9-27(12-16-5-6-16)20-11-19(23-14-24-20)22(30)25-18-8-7-17(10-15(18)2)33(31,32)26(3)13-21(28)29/h7-8,10-11,14,16H,4-6,9,12-13H2,1-3H3,(H,25,30)(H,28,29)
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n/an/an/an/a 1.23E+3n/an/a7.430



MERCK SERONO SA

US Patent


Assay Description
Measurements of 35S-GTPgammaS Binding: Membranes (1 to 10 µg protein) prepared as described above, were incubated in 96-well Scintiplates (PerkinElm...

US Patent US9150519 (2015)


BindingDB Entry DOI: 10.7270/Q2H993ZK
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 242 total )  |  Next  |  Last  >>
* indicates data uncertainty>20%