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USPatent US9533989

Compile data set for download or QSAR
Found 123 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM260691
PNG
(US9533989, 1)
Show SMILES N[C@H]1CCCC[C@H]1Nc1nc(Nc2cccc3[nH]ccc23)c2c(cc[nH]c2=O)n1
Show InChI InChI=1S/C21H23N7O/c22-13-4-1-2-5-16(13)26-21-27-17-9-11-24-20(29)18(17)19(28-21)25-15-7-3-6-14-12(15)8-10-23-14/h3,6-11,13,16,23H,1-2,4-5,22H2,(H,24,29)(H2,25,26,27,28)/t13-,16+/m0/s1
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n/an/a 0.809n/an/an/an/an/an/a



Ziarco Pharma Ltd.

US Patent


Assay Description
The Promega ADP-Glo Kinase Assay is a luminescent ADP detection assay that provides a universal, homogeneous, high-throughput screening method to mea...

US Patent US9533989 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ31M7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM260692
PNG
(US9533989, 2 | US9533989, 31)
Show SMILES N[C@H]1CCCC[C@H]1Nc1ncc(C(N)=O)c(Nc2cccc3n(CCCc4ccc(O)cc4)ccc23)n1
Show InChI InChI=1S/C28H33N7O2/c29-22-6-1-2-7-24(22)33-28-31-17-21(26(30)37)27(34-28)32-23-8-3-9-25-20(23)14-16-35(25)15-4-5-18-10-12-19(36)13-11-18/h3,8-14,16-17,22,24,36H,1-2,4-7,15,29H2,(H2,30,37)(H2,31,32,33,34)/t22-,24+/m0/s1
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n/an/a 1.18n/an/an/an/an/an/a



Ziarco Pharma Ltd.

US Patent


Assay Description
The Promega ADP-Glo Kinase Assay is a luminescent ADP detection assay that provides a universal, homogeneous, high-throughput screening method to mea...

US Patent US9533989 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ31M7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM260693
PNG
(US9533989, 3)
Show SMILES N[C@H]1CCCC[C@H]1Nc1ncc(C(N)=O)c(Nc2cccc3n(CCCc4cccc(O)c4)ccc23)n1
Show InChI InChI=1S/C28H33N7O2/c29-22-9-1-2-10-24(22)33-28-31-17-21(26(30)37)27(34-28)32-23-11-4-12-25-20(23)13-15-35(25)14-5-7-18-6-3-8-19(36)16-18/h3-4,6,8,11-13,15-17,22,24,36H,1-2,5,7,9-10,14,29H2,(H2,30,37)(H2,31,32,33,34)/t22-,24+/m0/s1
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Ziarco Pharma Ltd.

US Patent


Assay Description
The Promega ADP-Glo Kinase Assay is a luminescent ADP detection assay that provides a universal, homogeneous, high-throughput screening method to mea...

US Patent US9533989 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ31M7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM260694
PNG
(US9533989, 13 | US9533989, 4)
Show SMILES N[C@H]1CCCC[C@H]1Nc1ncc(C(N)=O)c(Nc2cccc(c2)-c2ccc(O)cc2)n1
Show InChI InChI=1S/C23H26N6O2/c24-19-6-1-2-7-20(19)28-23-26-13-18(21(25)31)22(29-23)27-16-5-3-4-15(12-16)14-8-10-17(30)11-9-14/h3-5,8-13,19-20,30H,1-2,6-7,24H2,(H2,25,31)(H2,26,27,28,29)/t19-,20+/m0/s1
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n/an/a 1.57n/an/an/an/an/an/a



Ziarco Pharma Ltd.

US Patent


Assay Description
The Promega ADP-Glo Kinase Assay is a luminescent ADP detection assay that provides a universal, homogeneous, high-throughput screening method to mea...

US Patent US9533989 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ31M7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM260695
PNG
(US9533989, 5 | US9533989, 8)
Show SMILES N[C@H]1CCCC[C@H]1Nc1ncc(C(N)=O)c(Nc2cccc(c2)-c2cccc(O)c2)n1
Show InChI InChI=1S/C23H26N6O2/c24-19-9-1-2-10-20(19)28-23-26-13-18(21(25)31)22(29-23)27-16-7-3-5-14(11-16)15-6-4-8-17(30)12-15/h3-8,11-13,19-20,30H,1-2,9-10,24H2,(H2,25,31)(H2,26,27,28,29)/t19-,20+/m0/s1
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Ziarco Pharma Ltd.

US Patent


Assay Description
The Promega ADP-Glo Kinase Assay is a luminescent ADP detection assay that provides a universal, homogeneous, high-throughput screening method to mea...

US Patent US9533989 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ31M7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM260696
PNG
(US9533989, 6)
Show SMILES Cc1ccc(Cn2ccc3c(Nc4nc(N[C@@H]5CCCC[C@@H]5N)ncc4C(N)=O)cccc23)cc1
Show InChI InChI=1S/C27H31N7O/c1-17-9-11-18(12-10-17)16-34-14-13-19-22(7-4-8-24(19)34)31-26-20(25(29)35)15-30-27(33-26)32-23-6-3-2-5-21(23)28/h4,7-15,21,23H,2-3,5-6,16,28H2,1H3,(H2,29,35)(H2,30,31,32,33)/t21-,23+/m0/s1
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Ziarco Pharma Ltd.

US Patent


Assay Description
The Promega ADP-Glo Kinase Assay is a luminescent ADP detection assay that provides a universal, homogeneous, high-throughput screening method to mea...

US Patent US9533989 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ31M7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM260697
PNG
(US9533989, 7)
Show SMILES COc1cccc(CCCn2ccc3c(Nc4nc(N[C@@H]5CCCC[C@@H]5N)ncc4C(N)=O)cccc23)c1
Show InChI InChI=1S/C29H35N7O2/c1-38-20-9-4-7-19(17-20)8-6-15-36-16-14-21-24(12-5-13-26(21)36)33-28-22(27(31)37)18-32-29(35-28)34-25-11-3-2-10-23(25)30/h4-5,7,9,12-14,16-18,23,25H,2-3,6,8,10-11,15,30H2,1H3,(H2,31,37)(H2,32,33,34,35)/t23-,25+/m0/s1
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Ziarco Pharma Ltd.

US Patent


Assay Description
The Promega ADP-Glo Kinase Assay is a luminescent ADP detection assay that provides a universal, homogeneous, high-throughput screening method to mea...

US Patent US9533989 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ31M7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM260695
PNG
(US9533989, 5 | US9533989, 8)
Show SMILES N[C@H]1CCCC[C@H]1Nc1ncc(C(N)=O)c(Nc2cccc(c2)-c2cccc(O)c2)n1
Show InChI InChI=1S/C23H26N6O2/c24-19-9-1-2-10-20(19)28-23-26-13-18(21(25)31)22(29-23)27-16-7-3-5-14(11-16)15-6-4-8-17(30)12-15/h3-8,11-13,19-20,30H,1-2,9-10,24H2,(H2,25,31)(H2,26,27,28,29)/t19-,20+/m0/s1
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Ziarco Pharma Ltd.

US Patent


Assay Description
The Promega ADP-Glo Kinase Assay is a luminescent ADP detection assay that provides a universal, homogeneous, high-throughput screening method to mea...

US Patent US9533989 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ31M7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM260699
PNG
(US9533989, 9)
Show SMILES Cc1cccc(Cn2ccc3c(Nc4nc(N[C@@H]5CCCC[C@@H]5N)ncc4C(N)=O)cccc23)c1
Show InChI InChI=1S/C27H31N7O/c1-17-6-4-7-18(14-17)16-34-13-12-19-22(10-5-11-24(19)34)31-26-20(25(29)35)15-30-27(33-26)32-23-9-3-2-8-21(23)28/h4-7,10-15,21,23H,2-3,8-9,16,28H2,1H3,(H2,29,35)(H2,30,31,32,33)/t21-,23+/m0/s1
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Ziarco Pharma Ltd.

US Patent


Assay Description
The Promega ADP-Glo Kinase Assay is a luminescent ADP detection assay that provides a universal, homogeneous, high-throughput screening method to mea...

US Patent US9533989 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ31M7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM260700
PNG
(US9533989, 10)
Show SMILES N[C@H]1CCCC[C@H]1Nc1ncc(C(N)=O)c(Nc2cccc3n(Cc4ccccc4)ccc23)n1
Show InChI InChI=1S/C26H29N7O/c27-20-9-4-5-10-22(20)31-26-29-15-19(24(28)34)25(32-26)30-21-11-6-12-23-18(21)13-14-33(23)16-17-7-2-1-3-8-17/h1-3,6-8,11-15,20,22H,4-5,9-10,16,27H2,(H2,28,34)(H2,29,30,31,32)/t20-,22+/m0/s1
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Ziarco Pharma Ltd.

US Patent


Assay Description
The Promega ADP-Glo Kinase Assay is a luminescent ADP detection assay that provides a universal, homogeneous, high-throughput screening method to mea...

US Patent US9533989 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ31M7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM260701
PNG
(US9533989, 11)
Show SMILES COc1cc(Nc2nc(N[C@@H]3CCCC[C@@H]3N)nc(O)c2C(N)=O)cc(OC)c1
Show InChI InChI=1S/C19H26N6O4/c1-28-11-7-10(8-12(9-11)29-2)22-17-15(16(21)26)18(27)25-19(24-17)23-14-6-4-3-5-13(14)20/h7-9,13-14H,3-6,20H2,1-2H3,(H2,21,26)(H3,22,23,24,25,27)/t13-,14+/m0/s1
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Ziarco Pharma Ltd.

US Patent


Assay Description
The Promega ADP-Glo Kinase Assay is a luminescent ADP detection assay that provides a universal, homogeneous, high-throughput screening method to mea...

US Patent US9533989 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ31M7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM260702
PNG
(US9533989, 12)
Show SMILES N[C@H]1CCCC[C@H]1Nc1ncc(C(N)=O)c(Nc2ccc3CCN(Cc3c2)C(=O)c2cccnc2)n1
Show InChI InChI=1S/C26H30N8O2/c27-21-5-1-2-6-22(21)32-26-30-14-20(23(28)35)24(33-26)31-19-8-7-16-9-11-34(15-18(16)12-19)25(36)17-4-3-10-29-13-17/h3-4,7-8,10,12-14,21-22H,1-2,5-6,9,11,15,27H2,(H2,28,35)(H2,30,31,32,33)/t21-,22+/m0/s1
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Ziarco Pharma Ltd.

US Patent


Assay Description
The Promega ADP-Glo Kinase Assay is a luminescent ADP detection assay that provides a universal, homogeneous, high-throughput screening method to mea...

US Patent US9533989 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ31M7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM260694
PNG
(US9533989, 13 | US9533989, 4)
Show SMILES N[C@H]1CCCC[C@H]1Nc1ncc(C(N)=O)c(Nc2cccc(c2)-c2ccc(O)cc2)n1
Show InChI InChI=1S/C23H26N6O2/c24-19-6-1-2-7-20(19)28-23-26-13-18(21(25)31)22(29-23)27-16-5-3-4-15(12-16)14-8-10-17(30)11-9-14/h3-5,8-13,19-20,30H,1-2,6-7,24H2,(H2,25,31)(H2,26,27,28,29)/t19-,20+/m0/s1
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Ziarco Pharma Ltd.

US Patent


Assay Description
The Promega ADP-Glo Kinase Assay is a luminescent ADP detection assay that provides a universal, homogeneous, high-throughput screening method to mea...

US Patent US9533989 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ31M7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM260704
PNG
(US9533989, 14 | US9533989, 30)
Show SMILES N[C@H]1CCCC[C@H]1Nc1ncc(C(N)=O)c(Nc2cccc3n(CCc4ccc(O)cc4)ccc23)n1
Show InChI InChI=1S/C27H31N7O2/c28-21-4-1-2-5-23(21)32-27-30-16-20(25(29)36)26(33-27)31-22-6-3-7-24-19(22)13-15-34(24)14-12-17-8-10-18(35)11-9-17/h3,6-11,13,15-16,21,23,35H,1-2,4-5,12,14,28H2,(H2,29,36)(H2,30,31,32,33)/t21-,23+/m0/s1
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Ziarco Pharma Ltd.

US Patent


Assay Description
The Promega ADP-Glo Kinase Assay is a luminescent ADP detection assay that provides a universal, homogeneous, high-throughput screening method to mea...

US Patent US9533989 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ31M7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM260705
PNG
(US9533989, 15)
Show SMILES N[C@H]1CCCC[C@H]1Nc1ncc(C(N)=O)c(Nc2ccc3CCN(Cc3c2)C(=O)C2CCC2)n1
Show InChI InChI=1S/C25H33N7O2/c26-20-6-1-2-7-21(20)30-25-28-13-19(22(27)33)23(31-25)29-18-9-8-15-10-11-32(14-17(15)12-18)24(34)16-4-3-5-16/h8-9,12-13,16,20-21H,1-7,10-11,14,26H2,(H2,27,33)(H2,28,29,30,31)/t20-,21+/m0/s1
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Ziarco Pharma Ltd.

US Patent


Assay Description
The Promega ADP-Glo Kinase Assay is a luminescent ADP detection assay that provides a universal, homogeneous, high-throughput screening method to mea...

US Patent US9533989 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ31M7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM260706
PNG
(US9533989, 16)
Show SMILES N[C@H]1CCCC[C@H]1Nc1ncc(C(N)=O)c(Nc2ccc3CCN(Cc3c2)C(=O)Cc2ccccc2)n1
Show InChI InChI=1S/C28H33N7O2/c29-23-8-4-5-9-24(23)33-28-31-16-22(26(30)37)27(34-28)32-21-11-10-19-12-13-35(17-20(19)15-21)25(36)14-18-6-2-1-3-7-18/h1-3,6-7,10-11,15-16,23-24H,4-5,8-9,12-14,17,29H2,(H2,30,37)(H2,31,32,33,34)/t23-,24+/m0/s1
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Ziarco Pharma Ltd.

US Patent


Assay Description
The Promega ADP-Glo Kinase Assay is a luminescent ADP detection assay that provides a universal, homogeneous, high-throughput screening method to mea...

US Patent US9533989 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ31M7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM260707
PNG
(US9533989, 17)
Show SMILES Cc1cccc(c1)-c1cccc(Nc2nc(N[C@@H]3CCCC[C@@H]3N)ncc2C(N)=O)c1
Show InChI InChI=1S/C24H28N6O/c1-15-6-4-7-16(12-15)17-8-5-9-18(13-17)28-23-19(22(26)31)14-27-24(30-23)29-21-11-3-2-10-20(21)25/h4-9,12-14,20-21H,2-3,10-11,25H2,1H3,(H2,26,31)(H2,27,28,29,30)/t20-,21+/m0/s1
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Ziarco Pharma Ltd.

US Patent


Assay Description
The Promega ADP-Glo Kinase Assay is a luminescent ADP detection assay that provides a universal, homogeneous, high-throughput screening method to mea...

US Patent US9533989 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ31M7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM260708
PNG
(US9533989, 18 | US9533989, 41)
Show SMILES COc1ccc(CCCn2ccc3c(Nc4nc(N[C@@H]5CCCC[C@@H]5N)ncc4C(N)=O)cccc23)cc1
Show InChI InChI=1S/C29H35N7O2/c1-38-20-13-11-19(12-14-20)6-5-16-36-17-15-21-24(9-4-10-26(21)36)33-28-22(27(31)37)18-32-29(35-28)34-25-8-3-2-7-23(25)30/h4,9-15,17-18,23,25H,2-3,5-8,16,30H2,1H3,(H2,31,37)(H2,32,33,34,35)/t23-,25+/m0/s1
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n/an/a 5.49n/an/an/an/an/an/a



Ziarco Pharma Ltd.

US Patent


Assay Description
The Promega ADP-Glo Kinase Assay is a luminescent ADP detection assay that provides a universal, homogeneous, high-throughput screening method to mea...

US Patent US9533989 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ31M7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM260709
PNG
(US9533989, 19)
Show SMILES CCC(=O)N1CCc2ccc(Nc3nc(N[C@@H]4CCCC[C@@H]4N)ncc3C(N)=O)cc2C1
Show InChI InChI=1S/C23H31N7O2/c1-2-20(31)30-10-9-14-7-8-16(11-15(14)13-30)27-22-17(21(25)32)12-26-23(29-22)28-19-6-4-3-5-18(19)24/h7-8,11-12,18-19H,2-6,9-10,13,24H2,1H3,(H2,25,32)(H2,26,27,28,29)/t18-,19+/m0/s1
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n/an/a 5.62n/an/an/an/an/an/a



Ziarco Pharma Ltd.

US Patent


Assay Description
The Promega ADP-Glo Kinase Assay is a luminescent ADP detection assay that provides a universal, homogeneous, high-throughput screening method to mea...

US Patent US9533989 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ31M7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM260710
PNG
(US9533989, 20 | US9533989, 35)
Show SMILES COc1ccc(CCn2ccc3c(Nc4nc(N[C@@H]5CCCC[C@@H]5N)ncc4C(N)=O)cccc23)cc1
Show InChI InChI=1S/C28H33N7O2/c1-37-19-11-9-18(10-12-19)13-15-35-16-14-20-23(7-4-8-25(20)35)32-27-21(26(30)36)17-31-28(34-27)33-24-6-3-2-5-22(24)29/h4,7-12,14,16-17,22,24H,2-3,5-6,13,15,29H2,1H3,(H2,30,36)(H2,31,32,33,34)/t22-,24+/m0/s1
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Ziarco Pharma Ltd.

US Patent


Assay Description
The Promega ADP-Glo Kinase Assay is a luminescent ADP detection assay that provides a universal, homogeneous, high-throughput screening method to mea...

US Patent US9533989 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ31M7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM260711
PNG
(US9533989, 21)
Show SMILES N[C@H]1CCCC[C@H]1Nc1ncc(C(N)=O)c(Nc2cccc3n(Cc4ccc(Cl)cc4)ccc23)n1
Show InChI InChI=1S/C26H28ClN7O/c27-17-10-8-16(9-11-17)15-34-13-12-18-21(6-3-7-23(18)34)31-25-19(24(29)35)14-30-26(33-25)32-22-5-2-1-4-20(22)28/h3,6-14,20,22H,1-2,4-5,15,28H2,(H2,29,35)(H2,30,31,32,33)/t20-,22+/m0/s1
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Ziarco Pharma Ltd.

US Patent


Assay Description
The Promega ADP-Glo Kinase Assay is a luminescent ADP detection assay that provides a universal, homogeneous, high-throughput screening method to mea...

US Patent US9533989 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ31M7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM260712
PNG
(US9533989, 22)
Show SMILES N[C@H]1CCCC[C@H]1Nc1ncc(C(N)=O)c(Nc2cccc3n(CCc4cccc(O)c4)ccc23)n1
Show InChI InChI=1S/C27H31N7O2/c28-21-7-1-2-8-23(21)32-27-30-16-20(25(29)36)26(33-27)31-22-9-4-10-24-19(22)12-14-34(24)13-11-17-5-3-6-18(35)15-17/h3-6,9-10,12,14-16,21,23,35H,1-2,7-8,11,13,28H2,(H2,29,36)(H2,30,31,32,33)/t21-,23+/m0/s1
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Ziarco Pharma Ltd.

US Patent


Assay Description
The Promega ADP-Glo Kinase Assay is a luminescent ADP detection assay that provides a universal, homogeneous, high-throughput screening method to mea...

US Patent US9533989 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ31M7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM260713
PNG
(US9533989, 23)
Show SMILES COc1ccccc1CCCn1ccc2c(Nc3nc(N[C@@H]4CCCC[C@@H]4N)ncc3C(N)=O)cccc12
Show InChI InChI=1S/C29H35N7O2/c1-38-26-14-5-2-8-19(26)9-7-16-36-17-15-20-23(12-6-13-25(20)36)33-28-21(27(31)37)18-32-29(35-28)34-24-11-4-3-10-22(24)30/h2,5-6,8,12-15,17-18,22,24H,3-4,7,9-11,16,30H2,1H3,(H2,31,37)(H2,32,33,34,35)/t22-,24+/m0/s1
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Ziarco Pharma Ltd.

US Patent


Assay Description
The Promega ADP-Glo Kinase Assay is a luminescent ADP detection assay that provides a universal, homogeneous, high-throughput screening method to mea...

US Patent US9533989 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ31M7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM260714
PNG
(US9533989, 24)
Show SMILES N[C@H]1CCCC[C@H]1Nc1ncc(C(N)=O)c(Nc2ccc3CCN(Cc3c2)C(=O)c2ccncc2)n1
Show InChI InChI=1S/C26H30N8O2/c27-21-3-1-2-4-22(21)32-26-30-14-20(23(28)35)24(33-26)31-19-6-5-16-9-12-34(15-18(16)13-19)25(36)17-7-10-29-11-8-17/h5-8,10-11,13-14,21-22H,1-4,9,12,15,27H2,(H2,28,35)(H2,30,31,32,33)/t21-,22+/m0/s1
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Ziarco Pharma Ltd.

US Patent


Assay Description
The Promega ADP-Glo Kinase Assay is a luminescent ADP detection assay that provides a universal, homogeneous, high-throughput screening method to mea...

US Patent US9533989 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ31M7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM260715
PNG
(US9533989, 25)
Show SMILES N[C@H]1CCCC[C@H]1Nc1nc(Nc2cccc(c2)-c2ccccc2)c(C(N)=O)c2nccn12
Show InChI InChI=1S/C25H27N7O/c26-19-11-4-5-12-20(19)30-25-31-23(21(22(27)33)24-28-13-14-32(24)25)29-18-10-6-9-17(15-18)16-7-2-1-3-8-16/h1-3,6-10,13-15,19-20,29H,4-5,11-12,26H2,(H2,27,33)(H,30,31)/t19-,20+/m0/s1
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Ziarco Pharma Ltd.

US Patent


Assay Description
The Promega ADP-Glo Kinase Assay is a luminescent ADP detection assay that provides a universal, homogeneous, high-throughput screening method to mea...

US Patent US9533989 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ31M7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM260716
PNG
(US9533989, 26)
Show SMILES N[C@H]1CCCC[C@H]1Nc1ncc(C(N)=O)c(Nc2cccc3n(CCc4ccccc4O)ccc23)n1
Show InChI InChI=1S/C27H31N7O2/c28-20-7-2-3-8-22(20)32-27-30-16-19(25(29)36)26(33-27)31-21-9-5-10-23-18(21)13-15-34(23)14-12-17-6-1-4-11-24(17)35/h1,4-6,9-11,13,15-16,20,22,35H,2-3,7-8,12,14,28H2,(H2,29,36)(H2,30,31,32,33)/t20-,22+/m0/s1
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Ziarco Pharma Ltd.

US Patent


Assay Description
The Promega ADP-Glo Kinase Assay is a luminescent ADP detection assay that provides a universal, homogeneous, high-throughput screening method to mea...

US Patent US9533989 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ31M7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM260717
PNG
(US9533989, 27)
Show SMILES N[C@H]1CCCC[C@H]1Nc1ncc(C(N)=O)c(Nc2ccc3CCN(Cc3c2)C(=O)c2ccc(O)cc2)n1
Show InChI InChI=1S/C27H31N7O3/c28-22-3-1-2-4-23(22)32-27-30-14-21(24(29)36)25(33-27)31-19-8-5-16-11-12-34(15-18(16)13-19)26(37)17-6-9-20(35)10-7-17/h5-10,13-14,22-23,35H,1-4,11-12,15,28H2,(H2,29,36)(H2,30,31,32,33)/t22-,23+/m0/s1
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Ziarco Pharma Ltd.

US Patent


Assay Description
The Promega ADP-Glo Kinase Assay is a luminescent ADP detection assay that provides a universal, homogeneous, high-throughput screening method to mea...

US Patent US9533989 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ31M7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM260718
PNG
(US9533989, 108 | US9533989, 28)
Show SMILES N[C@H]1CCCC[C@H]1Nc1ncc(C(N)=O)c(Nc2cccc3n(Cc4ccc(O)cc4)ccc23)n1
Show InChI InChI=1S/C26H29N7O2/c27-20-4-1-2-5-22(20)31-26-29-14-19(24(28)35)25(32-26)30-21-6-3-7-23-18(21)12-13-33(23)15-16-8-10-17(34)11-9-16/h3,6-14,20,22,34H,1-2,4-5,15,27H2,(H2,28,35)(H2,29,30,31,32)/t20-,22+/m0/s1
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Ziarco Pharma Ltd.

US Patent


Assay Description
The Promega ADP-Glo Kinase Assay is a luminescent ADP detection assay that provides a universal, homogeneous, high-throughput screening method to mea...

US Patent US9533989 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ31M7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM260719
PNG
(US9533989, 29)
Show SMILES N[C@H]1CCCC[C@H]1Nc1ncc(C(N)=O)c(Nc2ccc3n(Cc4ccccc4)ccc3c2)n1
Show InChI InChI=1S/C26H29N7O/c27-21-8-4-5-9-22(21)31-26-29-15-20(24(28)34)25(32-26)30-19-10-11-23-18(14-19)12-13-33(23)16-17-6-2-1-3-7-17/h1-3,6-7,10-15,21-22H,4-5,8-9,16,27H2,(H2,28,34)(H2,29,30,31,32)/t21-,22+/m0/s1
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Ziarco Pharma Ltd.

US Patent


Assay Description
The Promega ADP-Glo Kinase Assay is a luminescent ADP detection assay that provides a universal, homogeneous, high-throughput screening method to mea...

US Patent US9533989 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ31M7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM260704
PNG
(US9533989, 14 | US9533989, 30)
Show SMILES N[C@H]1CCCC[C@H]1Nc1ncc(C(N)=O)c(Nc2cccc3n(CCc4ccc(O)cc4)ccc23)n1
Show InChI InChI=1S/C27H31N7O2/c28-21-4-1-2-5-23(21)32-27-30-16-20(25(29)36)26(33-27)31-22-6-3-7-24-19(22)13-15-34(24)14-12-17-8-10-18(35)11-9-17/h3,6-11,13,15-16,21,23,35H,1-2,4-5,12,14,28H2,(H2,29,36)(H2,30,31,32,33)/t21-,23+/m0/s1
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Ziarco Pharma Ltd.

US Patent


Assay Description
The Promega ADP-Glo Kinase Assay is a luminescent ADP detection assay that provides a universal, homogeneous, high-throughput screening method to mea...

US Patent US9533989 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ31M7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM260692
PNG
(US9533989, 2 | US9533989, 31)
Show SMILES N[C@H]1CCCC[C@H]1Nc1ncc(C(N)=O)c(Nc2cccc3n(CCCc4ccc(O)cc4)ccc23)n1
Show InChI InChI=1S/C28H33N7O2/c29-22-6-1-2-7-24(22)33-28-31-17-21(26(30)37)27(34-28)32-23-8-3-9-25-20(23)14-16-35(25)15-4-5-18-10-12-19(36)13-11-18/h3,8-14,16-17,22,24,36H,1-2,4-7,15,29H2,(H2,30,37)(H2,31,32,33,34)/t22-,24+/m0/s1
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Ziarco Pharma Ltd.

US Patent


Assay Description
The Promega ADP-Glo Kinase Assay is a luminescent ADP detection assay that provides a universal, homogeneous, high-throughput screening method to mea...

US Patent US9533989 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ31M7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM260722
PNG
(US9533989, 32)
Show SMILES N[C@H]1CCCC[C@H]1Nc1ncc(C(N)=O)c(Nc2cccc3n(Cc4cccc(O)c4)ccc23)n1
Show InChI InChI=1S/C26H29N7O2/c27-20-7-1-2-8-22(20)31-26-29-14-19(24(28)35)25(32-26)30-21-9-4-10-23-18(21)11-12-33(23)15-16-5-3-6-17(34)13-16/h3-6,9-14,20,22,34H,1-2,7-8,15,27H2,(H2,28,35)(H2,29,30,31,32)/t20-,22+/m0/s1
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n/an/a 12n/an/an/an/an/an/a



Ziarco Pharma Ltd.

US Patent


Assay Description
The Promega ADP-Glo Kinase Assay is a luminescent ADP detection assay that provides a universal, homogeneous, high-throughput screening method to mea...

US Patent US9533989 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ31M7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM260723
PNG
(US9533989, 33)
Show SMILES N[C@H]1CCCC[C@H]1Nc1ncc(C(N)=O)c(Nc2cccc3n(CCCc4ccccc4)ccc23)n1
Show InChI InChI=1S/C28H33N7O/c29-22-11-4-5-12-24(22)33-28-31-18-21(26(30)36)27(34-28)32-23-13-6-14-25-20(23)15-17-35(25)16-7-10-19-8-2-1-3-9-19/h1-3,6,8-9,13-15,17-18,22,24H,4-5,7,10-12,16,29H2,(H2,30,36)(H2,31,32,33,34)/t22-,24+/m0/s1
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n/an/a 12.1n/an/an/an/an/an/a



Ziarco Pharma Ltd.

US Patent


Assay Description
The Promega ADP-Glo Kinase Assay is a luminescent ADP detection assay that provides a universal, homogeneous, high-throughput screening method to mea...

US Patent US9533989 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ31M7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM260724
PNG
(US9533989, 34)
Show SMILES COc1cccc(CCn2ccc3c(Nc4nc(N[C@@H]5CCCC[C@@H]5N)ncc4C(N)=O)cccc23)c1
Show InChI InChI=1S/C28H33N7O2/c1-37-19-7-4-6-18(16-19)12-14-35-15-13-20-23(10-5-11-25(20)35)32-27-21(26(30)36)17-31-28(34-27)33-24-9-3-2-8-22(24)29/h4-7,10-11,13,15-17,22,24H,2-3,8-9,12,14,29H2,1H3,(H2,30,36)(H2,31,32,33,34)/t22-,24+/m0/s1
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Ziarco Pharma Ltd.

US Patent


Assay Description
The Promega ADP-Glo Kinase Assay is a luminescent ADP detection assay that provides a universal, homogeneous, high-throughput screening method to mea...

US Patent US9533989 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ31M7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM260710
PNG
(US9533989, 20 | US9533989, 35)
Show SMILES COc1ccc(CCn2ccc3c(Nc4nc(N[C@@H]5CCCC[C@@H]5N)ncc4C(N)=O)cccc23)cc1
Show InChI InChI=1S/C28H33N7O2/c1-37-19-11-9-18(10-12-19)13-15-35-16-14-20-23(7-4-8-25(20)35)32-27-21(26(30)36)17-31-28(34-27)33-24-6-3-2-5-22(24)29/h4,7-12,14,16-17,22,24H,2-3,5-6,13,15,29H2,1H3,(H2,30,36)(H2,31,32,33,34)/t22-,24+/m0/s1
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n/an/a 12.3n/an/an/an/an/an/a



Ziarco Pharma Ltd.

US Patent


Assay Description
The Promega ADP-Glo Kinase Assay is a luminescent ADP detection assay that provides a universal, homogeneous, high-throughput screening method to mea...

US Patent US9533989 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ31M7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM260726
PNG
(US9533989, 36)
Show SMILES COC(=O)N1CCc2ccc(Nc3nc(N[C@@H]4CCCC[C@@H]4N)ncc3C(N)=O)cc2C1
Show InChI InChI=1S/C22H29N7O3/c1-32-22(31)29-9-8-13-6-7-15(10-14(13)12-29)26-20-16(19(24)30)11-25-21(28-20)27-18-5-3-2-4-17(18)23/h6-7,10-11,17-18H,2-5,8-9,12,23H2,1H3,(H2,24,30)(H2,25,26,27,28)/t17-,18+/m0/s1
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Ziarco Pharma Ltd.

US Patent


Assay Description
The Promega ADP-Glo Kinase Assay is a luminescent ADP detection assay that provides a universal, homogeneous, high-throughput screening method to mea...

US Patent US9533989 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ31M7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM260727
PNG
(US9533989, 37)
Show SMILES COc1ccccc1CCn1ccc2c(Nc3nc(N[C@@H]4CCCC[C@@H]4N)ncc3C(N)=O)cccc12
Show InChI InChI=1S/C28H33N7O2/c1-37-25-12-5-2-7-18(25)13-15-35-16-14-19-22(10-6-11-24(19)35)32-27-20(26(30)36)17-31-28(34-27)33-23-9-4-3-8-21(23)29/h2,5-7,10-12,14,16-17,21,23H,3-4,8-9,13,15,29H2,1H3,(H2,30,36)(H2,31,32,33,34)/t21-,23+/m0/s1
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Ziarco Pharma Ltd.

US Patent


Assay Description
The Promega ADP-Glo Kinase Assay is a luminescent ADP detection assay that provides a universal, homogeneous, high-throughput screening method to mea...

US Patent US9533989 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ31M7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM260728
PNG
(US9533989, 38)
Show SMILES CCOC(=O)N1CCc2ccc(Nc3nc(N[C@@H]4CCCC[C@@H]4N)ncc3C(N)=O)cc2C1
Show InChI InChI=1S/C23H31N7O3/c1-2-33-23(32)30-10-9-14-7-8-16(11-15(14)13-30)27-21-17(20(25)31)12-26-22(29-21)28-19-6-4-3-5-18(19)24/h7-8,11-12,18-19H,2-6,9-10,13,24H2,1H3,(H2,25,31)(H2,26,27,28,29)/t18-,19+/m0/s1
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Ziarco Pharma Ltd.

US Patent


Assay Description
The Promega ADP-Glo Kinase Assay is a luminescent ADP detection assay that provides a universal, homogeneous, high-throughput screening method to mea...

US Patent US9533989 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ31M7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM260729
PNG
(US9533989, 39)
Show SMILES N[C@H]1CCCC[C@H]1Nc1ncc(C(N)=O)c(Nc2cccc3n(CCc4ccccc4)ccc23)n1
Show InChI InChI=1S/C27H31N7O/c28-21-9-4-5-10-23(21)32-27-30-17-20(25(29)35)26(33-27)31-22-11-6-12-24-19(22)14-16-34(24)15-13-18-7-2-1-3-8-18/h1-3,6-8,11-12,14,16-17,21,23H,4-5,9-10,13,15,28H2,(H2,29,35)(H2,30,31,32,33)/t21-,23+/m0/s1
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Ziarco Pharma Ltd.

US Patent


Assay Description
The Promega ADP-Glo Kinase Assay is a luminescent ADP detection assay that provides a universal, homogeneous, high-throughput screening method to mea...

US Patent US9533989 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ31M7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM260730
PNG
(US9533989, 40)
Show SMILES CCS(=O)(=O)N1CCc2ccc(Nc3nc(N[C@@H]4CCCC[C@@H]4N)ncc3C(N)=O)cc2C1
Show InChI InChI=1S/C22H31N7O3S/c1-2-33(31,32)29-10-9-14-7-8-16(11-15(14)13-29)26-21-17(20(24)30)12-25-22(28-21)27-19-6-4-3-5-18(19)23/h7-8,11-12,18-19H,2-6,9-10,13,23H2,1H3,(H2,24,30)(H2,25,26,27,28)/t18-,19+/m0/s1
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Ziarco Pharma Ltd.

US Patent


Assay Description
The Promega ADP-Glo Kinase Assay is a luminescent ADP detection assay that provides a universal, homogeneous, high-throughput screening method to mea...

US Patent US9533989 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ31M7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM260708
PNG
(US9533989, 18 | US9533989, 41)
Show SMILES COc1ccc(CCCn2ccc3c(Nc4nc(N[C@@H]5CCCC[C@@H]5N)ncc4C(N)=O)cccc23)cc1
Show InChI InChI=1S/C29H35N7O2/c1-38-20-13-11-19(12-14-20)6-5-16-36-17-15-21-24(9-4-10-26(21)36)33-28-22(27(31)37)18-32-29(35-28)34-25-8-3-2-7-23(25)30/h4,9-15,17-18,23,25H,2-3,5-8,16,30H2,1H3,(H2,31,37)(H2,32,33,34,35)/t23-,25+/m0/s1
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Ziarco Pharma Ltd.

US Patent


Assay Description
The Promega ADP-Glo Kinase Assay is a luminescent ADP detection assay that provides a universal, homogeneous, high-throughput screening method to mea...

US Patent US9533989 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ31M7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM260732
PNG
(US9533989, 42)
Show SMILES N[C@H]1CCCC[C@H]1Nc1ncc(C(N)=O)c(Nc2ccc3ccn(Cc4ccccc4)c3c2)n1
Show InChI InChI=1S/C26H29N7O/c27-21-8-4-5-9-22(21)31-26-29-15-20(24(28)34)25(32-26)30-19-11-10-18-12-13-33(23(18)14-19)16-17-6-2-1-3-7-17/h1-3,6-7,10-15,21-22H,4-5,8-9,16,27H2,(H2,28,34)(H2,29,30,31,32)/t21-,22+/m0/s1
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Ziarco Pharma Ltd.

US Patent


Assay Description
The Promega ADP-Glo Kinase Assay is a luminescent ADP detection assay that provides a universal, homogeneous, high-throughput screening method to mea...

US Patent US9533989 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ31M7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM260733
PNG
(US9533989, 43)
Show SMILES N[C@H]1CCCC[C@H]1Nc1ncc(C(N)=O)c(Nc2ccc3CCN(Cc3c2)C(=O)c2ccccc2O)n1
Show InChI InChI=1S/C27H31N7O3/c28-21-6-2-3-7-22(21)32-27-30-14-20(24(29)36)25(33-27)31-18-10-9-16-11-12-34(15-17(16)13-18)26(37)19-5-1-4-8-23(19)35/h1,4-5,8-10,13-14,21-22,35H,2-3,6-7,11-12,15,28H2,(H2,29,36)(H2,30,31,32,33)/t21-,22+/m0/s1
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Ziarco Pharma Ltd.

US Patent


Assay Description
The Promega ADP-Glo Kinase Assay is a luminescent ADP detection assay that provides a universal, homogeneous, high-throughput screening method to mea...

US Patent US9533989 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ31M7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM260734
PNG
(US9533989, 44)
Show SMILES N[C@H]1CCCC[C@H]1Nc1ncc(C(N)=O)c(NC2(O)CC(=CC=C2)c2ccc(Cl)cc2)n1 |c:21,23|
Show InChI InChI=1S/C23H27ClN6O2/c24-16-9-7-14(8-10-16)15-4-3-11-23(32,12-15)30-21-17(20(26)31)13-27-22(29-21)28-19-6-2-1-5-18(19)25/h3-4,7-11,13,18-19,32H,1-2,5-6,12,25H2,(H2,26,31)(H2,27,28,29,30)/t18-,19+,23?/m0/s1
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Ziarco Pharma Ltd.

US Patent


Assay Description
The Promega ADP-Glo Kinase Assay is a luminescent ADP detection assay that provides a universal, homogeneous, high-throughput screening method to mea...

US Patent US9533989 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ31M7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM260735
PNG
(US9533989, 45)
Show SMILES N[C@H]1CCCC[C@H]1Nc1ncc(C(N)=O)c(Nc2ccc3CCN(Cc3c2)C(=O)Oc2ccccc2)n1
Show InChI InChI=1S/C27H31N7O3/c28-22-8-4-5-9-23(22)32-26-30-15-21(24(29)35)25(33-26)31-19-11-10-17-12-13-34(16-18(17)14-19)27(36)37-20-6-2-1-3-7-20/h1-3,6-7,10-11,14-15,22-23H,4-5,8-9,12-13,16,28H2,(H2,29,35)(H2,30,31,32,33)/t22-,23+/m0/s1
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Ziarco Pharma Ltd.

US Patent


Assay Description
The Promega ADP-Glo Kinase Assay is a luminescent ADP detection assay that provides a universal, homogeneous, high-throughput screening method to mea...

US Patent US9533989 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ31M7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM260736
PNG
(US9533989, 46)
Show SMILES N[C@H]1CCCC[C@H]1Nc1ncc(C(N)=O)c(Nc2ccc3CCN(Cc3c2)C(=O)c2cccc(O)c2)n1
Show InChI InChI=1S/C27H31N7O3/c28-22-6-1-2-7-23(22)32-27-30-14-21(24(29)36)25(33-27)31-19-9-8-16-10-11-34(15-18(16)12-19)26(37)17-4-3-5-20(35)13-17/h3-5,8-9,12-14,22-23,35H,1-2,6-7,10-11,15,28H2,(H2,29,36)(H2,30,31,32,33)/t22-,23+/m0/s1
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Ziarco Pharma Ltd.

US Patent


Assay Description
The Promega ADP-Glo Kinase Assay is a luminescent ADP detection assay that provides a universal, homogeneous, high-throughput screening method to mea...

US Patent US9533989 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ31M7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM260737
PNG
(US9533989, 47)
Show SMILES N[C@H]1CCCC[C@H]1Nc1ncc(C(N)=O)c(Nc2ccc3CCN(Cc3c2)C(=O)c2ccccc2)n1
Show InChI InChI=1S/C27H31N7O2/c28-22-8-4-5-9-23(22)32-27-30-15-21(24(29)35)25(33-27)31-20-11-10-17-12-13-34(16-19(17)14-20)26(36)18-6-2-1-3-7-18/h1-3,6-7,10-11,14-15,22-23H,4-5,8-9,12-13,16,28H2,(H2,29,35)(H2,30,31,32,33)/t22-,23+/m0/s1
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Ziarco Pharma Ltd.

US Patent


Assay Description
The Promega ADP-Glo Kinase Assay is a luminescent ADP detection assay that provides a universal, homogeneous, high-throughput screening method to mea...

US Patent US9533989 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ31M7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM260738
PNG
(US9533989, 48)
Show SMILES CSc1cccc(c1)C(=O)N1CCc2ccc(Nc3nc(N[C@@H]4CCCC[C@@H]4N)ncc3C(N)=O)cc2C1
Show InChI InChI=1S/C28H33N7O2S/c1-38-21-6-4-5-18(14-21)27(37)35-12-11-17-9-10-20(13-19(17)16-35)32-26-22(25(30)36)15-31-28(34-26)33-24-8-3-2-7-23(24)29/h4-6,9-10,13-15,23-24H,2-3,7-8,11-12,16,29H2,1H3,(H2,30,36)(H2,31,32,33,34)/t23-,24+/m0/s1
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Ziarco Pharma Ltd.

US Patent


Assay Description
The Promega ADP-Glo Kinase Assay is a luminescent ADP detection assay that provides a universal, homogeneous, high-throughput screening method to mea...

US Patent US9533989 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ31M7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM260739
PNG
(US9533989, 49)
Show SMILES N[C@H]1CCCC[C@H]1Nc1ncc(C(N)=O)c(Nc2ccc3CCN(Cc3c2)S(=O)(=O)Cc2ccccc2)n1
Show InChI InChI=1S/C27H33N7O3S/c28-23-8-4-5-9-24(23)32-27-30-15-22(25(29)35)26(33-27)31-21-11-10-19-12-13-34(16-20(19)14-21)38(36,37)17-18-6-2-1-3-7-18/h1-3,6-7,10-11,14-15,23-24H,4-5,8-9,12-13,16-17,28H2,(H2,29,35)(H2,30,31,32,33)/t23-,24+/m0/s1
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Ziarco Pharma Ltd.

US Patent


Assay Description
The Promega ADP-Glo Kinase Assay is a luminescent ADP detection assay that provides a universal, homogeneous, high-throughput screening method to mea...

US Patent US9533989 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ31M7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM260740
PNG
(US9533989, 50)
Show SMILES CC(C)OC(=O)N1CCc2ccc(Nc3nc(N[C@@H]4CCCC[C@@H]4N)ncc3C(N)=O)cc2C1
Show InChI InChI=1S/C24H33N7O3/c1-14(2)34-24(33)31-10-9-15-7-8-17(11-16(15)13-31)28-22-18(21(26)32)12-27-23(30-22)29-20-6-4-3-5-19(20)25/h7-8,11-12,14,19-20H,3-6,9-10,13,25H2,1-2H3,(H2,26,32)(H2,27,28,29,30)/t19-,20+/m0/s1
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Ziarco Pharma Ltd.

US Patent


Assay Description
The Promega ADP-Glo Kinase Assay is a luminescent ADP detection assay that provides a universal, homogeneous, high-throughput screening method to mea...

US Patent US9533989 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ31M7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM260741
PNG
(US9533989, 51)
Show SMILES N[C@H]1CCCC[C@H]1Nc1ncc(C(N)=O)c(Nc2cccc(c2)-c2ccc(Cl)cc2)n1
Show InChI InChI=1S/C23H25ClN6O/c24-16-10-8-14(9-11-16)15-4-3-5-17(12-15)28-22-18(21(26)31)13-27-23(30-22)29-20-7-2-1-6-19(20)25/h3-5,8-13,19-20H,1-2,6-7,25H2,(H2,26,31)(H2,27,28,29,30)/t19-,20+/m0/s1
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Ziarco Pharma Ltd.

US Patent


Assay Description
The Promega ADP-Glo Kinase Assay is a luminescent ADP detection assay that provides a universal, homogeneous, high-throughput screening method to mea...

US Patent US9533989 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ31M7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM65363
PNG
(US9533989, 52)
Show SMILES CSc1cccc(Cn2ccc3c(Nc4nc(N[C@@H]5CCCC[C@@H]5N)ncc4C(N)=O)cccc23)c1
Show InChI InChI=1S/C27H31N7OS/c1-36-18-7-4-6-17(14-18)16-34-13-12-19-22(10-5-11-24(19)34)31-26-20(25(29)35)15-30-27(33-26)32-23-9-3-2-8-21(23)28/h4-7,10-15,21,23H,2-3,8-9,16,28H2,1H3,(H2,29,35)(H2,30,31,32,33)/t21-,23+/m0/s1
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Ziarco Pharma Ltd.

US Patent


Assay Description
The Promega ADP-Glo Kinase Assay is a luminescent ADP detection assay that provides a universal, homogeneous, high-throughput screening method to mea...

US Patent US9533989 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ31M7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM260742
PNG
(US9533989, 53)
Show SMILES CC(=O)N1CCc2ccc(Nc3nc(N[C@@H]4CCCC[C@@H]4N)ncc3C(N)=O)cc2C1
Show InChI InChI=1S/C22H29N7O2/c1-13(30)29-9-8-14-6-7-16(10-15(14)12-29)26-21-17(20(24)31)11-25-22(28-21)27-19-5-3-2-4-18(19)23/h6-7,10-11,18-19H,2-5,8-9,12,23H2,1H3,(H2,24,31)(H2,25,26,27,28)/t18-,19+/m0/s1
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Ziarco Pharma Ltd.

US Patent


Assay Description
The Promega ADP-Glo Kinase Assay is a luminescent ADP detection assay that provides a universal, homogeneous, high-throughput screening method to mea...

US Patent US9533989 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ31M7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM260743
PNG
(US9533989, 54)
Show SMILES N[C@H]1CCCC[C@H]1Nc1ncc(C(N)=O)c(Nc2cccc3n(Cc4ccccc4O)ccc23)n1
Show InChI InChI=1S/C26H29N7O2/c27-19-7-2-3-8-21(19)31-26-29-14-18(24(28)35)25(32-26)30-20-9-5-10-22-17(20)12-13-33(22)15-16-6-1-4-11-23(16)34/h1,4-6,9-14,19,21,34H,2-3,7-8,15,27H2,(H2,28,35)(H2,29,30,31,32)/t19-,21+/m0/s1
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Ziarco Pharma Ltd.

US Patent


Assay Description
The Promega ADP-Glo Kinase Assay is a luminescent ADP detection assay that provides a universal, homogeneous, high-throughput screening method to mea...

US Patent US9533989 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ31M7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM260744
PNG
(US9533989, 55)
Show SMILES N[C@H]1CCCC[C@H]1Nc1ncc(C(N)=O)c(Nc2ccc3CCN(Cc3c2)C(=O)OCc2ccccc2)n1
Show InChI InChI=1S/C28H33N7O3/c29-23-8-4-5-9-24(23)33-27-31-15-22(25(30)36)26(34-27)32-21-11-10-19-12-13-35(16-20(19)14-21)28(37)38-17-18-6-2-1-3-7-18/h1-3,6-7,10-11,14-15,23-24H,4-5,8-9,12-13,16-17,29H2,(H2,30,36)(H2,31,32,33,34)/t23-,24+/m0/s1
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Ziarco Pharma Ltd.

US Patent


Assay Description
The Promega ADP-Glo Kinase Assay is a luminescent ADP detection assay that provides a universal, homogeneous, high-throughput screening method to mea...

US Patent US9533989 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ31M7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM260745
PNG
(US9533989, 56)
Show SMILES N[C@H]1CCCC[C@H]1Nc1ncc(C(N)=O)c(Nc2ccc3CCN(Cc3c2)C(=O)c2cccc(F)c2)n1
Show InChI InChI=1S/C27H30FN7O2/c28-19-5-3-4-17(12-19)26(37)35-11-10-16-8-9-20(13-18(16)15-35)32-25-21(24(30)36)14-31-27(34-25)33-23-7-2-1-6-22(23)29/h3-5,8-9,12-14,22-23H,1-2,6-7,10-11,15,29H2,(H2,30,36)(H2,31,32,33,34)/t22-,23+/m0/s1
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Ziarco Pharma Ltd.

US Patent


Assay Description
The Promega ADP-Glo Kinase Assay is a luminescent ADP detection assay that provides a universal, homogeneous, high-throughput screening method to mea...

US Patent US9533989 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ31M7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM260746
PNG
(US9533989, 57)
Show SMILES N[C@H]1CCCC[C@H]1Nc1ncc(C(N)=O)c(Nc2ccc3CCN(Cc3c2)C(=O)OC2CC2)n1
Show InChI InChI=1S/C24H31N7O3/c25-19-3-1-2-4-20(19)29-23-27-12-18(21(26)32)22(30-23)28-16-6-5-14-9-10-31(13-15(14)11-16)24(33)34-17-7-8-17/h5-6,11-12,17,19-20H,1-4,7-10,13,25H2,(H2,26,32)(H2,27,28,29,30)/t19-,20+/m0/s1
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Ziarco Pharma Ltd.

US Patent


Assay Description
The Promega ADP-Glo Kinase Assay is a luminescent ADP detection assay that provides a universal, homogeneous, high-throughput screening method to mea...

US Patent US9533989 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ31M7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM260747
PNG
(US9533989, 58)
Show SMILES CS(=O)(=O)N1CCc2ccc(Nc3nc(N[C@@H]4CCCC[C@@H]4N)ncc3C(N)=O)cc2C1
Show InChI InChI=1S/C21H29N7O3S/c1-32(30,31)28-9-8-13-6-7-15(10-14(13)12-28)25-20-16(19(23)29)11-24-21(27-20)26-18-5-3-2-4-17(18)22/h6-7,10-11,17-18H,2-5,8-9,12,22H2,1H3,(H2,23,29)(H2,24,25,26,27)/t17-,18+/m0/s1
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Ziarco Pharma Ltd.

US Patent


Assay Description
The Promega ADP-Glo Kinase Assay is a luminescent ADP detection assay that provides a universal, homogeneous, high-throughput screening method to mea...

US Patent US9533989 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ31M7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM260748
PNG
(US9533989, 59)
Show SMILES N[C@H]1CCCC[C@H]1Nc1nc(Nc2cccc(c2)-c2ccc(O)cc2)c2c(cc[nH]c2=O)n1
Show InChI InChI=1S/C25H26N6O2/c26-19-6-1-2-7-20(19)29-25-30-21-12-13-27-24(33)22(21)23(31-25)28-17-5-3-4-16(14-17)15-8-10-18(32)11-9-15/h3-5,8-14,19-20,32H,1-2,6-7,26H2,(H,27,33)(H2,28,29,30,31)/t19-,20+/m0/s1
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Ziarco Pharma Ltd.

US Patent


Assay Description
The Promega ADP-Glo Kinase Assay is a luminescent ADP detection assay that provides a universal, homogeneous, high-throughput screening method to mea...

US Patent US9533989 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ31M7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM260750
PNG
(US9533989, 61)
Show SMILES N[C@H]1CCCC[C@H]1Nc1ncc(C(N)=O)c(Nc2ccc3CCN(Cc3c2)S(=O)(=O)C2CC2)n1
Show InChI InChI=1S/C23H31N7O3S/c24-19-3-1-2-4-20(19)28-23-26-12-18(21(25)31)22(29-23)27-16-6-5-14-9-10-30(13-15(14)11-16)34(32,33)17-7-8-17/h5-6,11-12,17,19-20H,1-4,7-10,13,24H2,(H2,25,31)(H2,26,27,28,29)/t19-,20+/m0/s1
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Ziarco Pharma Ltd.

US Patent


Assay Description
The Promega ADP-Glo Kinase Assay is a luminescent ADP detection assay that provides a universal, homogeneous, high-throughput screening method to mea...

US Patent US9533989 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ31M7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM260749
PNG
(US9533989, 60)
Show SMILES N[C@H]1CCCC[C@H]1Nc1ncc(C(N)=O)c(Nc2cccc3n(Cc4ccccc4F)ccc23)n1
Show InChI InChI=1S/C26H28FN7O/c27-19-7-2-1-6-16(19)15-34-13-12-17-21(10-5-11-23(17)34)31-25-18(24(29)35)14-30-26(33-25)32-22-9-4-3-8-20(22)28/h1-2,5-7,10-14,20,22H,3-4,8-9,15,28H2,(H2,29,35)(H2,30,31,32,33)/t20-,22+/m0/s1
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Ziarco Pharma Ltd.

US Patent


Assay Description
The Promega ADP-Glo Kinase Assay is a luminescent ADP detection assay that provides a universal, homogeneous, high-throughput screening method to mea...

US Patent US9533989 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ31M7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM260751
PNG
(US9533989, 62)
Show SMILES N[C@H]1CCCC[C@H]1Nc1ncc(C(N)=O)c(Nc2ccc3CCN(Cc3c2)C(=O)c2ccc(F)cc2)n1
Show InChI InChI=1S/C27H30FN7O2/c28-19-8-5-17(6-9-19)26(37)35-12-11-16-7-10-20(13-18(16)15-35)32-25-21(24(30)36)14-31-27(34-25)33-23-4-2-1-3-22(23)29/h5-10,13-14,22-23H,1-4,11-12,15,29H2,(H2,30,36)(H2,31,32,33,34)/t22-,23+/m0/s1
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Ziarco Pharma Ltd.

US Patent


Assay Description
The Promega ADP-Glo Kinase Assay is a luminescent ADP detection assay that provides a universal, homogeneous, high-throughput screening method to mea...

US Patent US9533989 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ31M7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM260752
PNG
(US9533989, 63)
Show SMILES CSc1ccc(Cn2ccc3c(Nc4nc(N[C@@H]5CCCC[C@@H]5N)ncc4C(N)=O)cccc23)cc1
Show InChI InChI=1S/C27H31N7OS/c1-36-18-11-9-17(10-12-18)16-34-14-13-19-22(7-4-8-24(19)34)31-26-20(25(29)35)15-30-27(33-26)32-23-6-3-2-5-21(23)28/h4,7-15,21,23H,2-3,5-6,16,28H2,1H3,(H2,29,35)(H2,30,31,32,33)/t21-,23+/m0/s1
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Ziarco Pharma Ltd.

US Patent


Assay Description
The Promega ADP-Glo Kinase Assay is a luminescent ADP detection assay that provides a universal, homogeneous, high-throughput screening method to mea...

US Patent US9533989 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ31M7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM260753
PNG
(US9533989, 64)
Show SMILES N[C@H]1CCCC[C@H]1Nc1ncc(C(N)=O)c(Nc2ccc3CCN(Cc3c2)c2ccccn2)n1
Show InChI InChI=1S/C25H30N8O/c26-20-5-1-2-6-21(20)31-25-29-14-19(23(27)34)24(32-25)30-18-9-8-16-10-12-33(15-17(16)13-18)22-7-3-4-11-28-22/h3-4,7-9,11,13-14,20-21H,1-2,5-6,10,12,15,26H2,(H2,27,34)(H2,29,30,31,32)/t20-,21+/m0/s1
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Ziarco Pharma Ltd.

US Patent


Assay Description
The Promega ADP-Glo Kinase Assay is a luminescent ADP detection assay that provides a universal, homogeneous, high-throughput screening method to mea...

US Patent US9533989 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ31M7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM260754
PNG
(US9533989, 65)
Show SMILES Cc1ccccc1Cn1ccc2c(Nc3nc(N[C@@H]4CCCC[C@@H]4N)ncc3C(N)=O)cccc12
Show InChI InChI=1S/C27H31N7O/c1-17-7-2-3-8-18(17)16-34-14-13-19-22(11-6-12-24(19)34)31-26-20(25(29)35)15-30-27(33-26)32-23-10-5-4-9-21(23)28/h2-3,6-8,11-15,21,23H,4-5,9-10,16,28H2,1H3,(H2,29,35)(H2,30,31,32,33)/t21-,23+/m0/s1
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Ziarco Pharma Ltd.

US Patent


Assay Description
The Promega ADP-Glo Kinase Assay is a luminescent ADP detection assay that provides a universal, homogeneous, high-throughput screening method to mea...

US Patent US9533989 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ31M7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM260755
PNG
(US9533989, 66)
Show SMILES Cc1cccc(c1)-c1cccc(Nc2nc(N[C@@H]3CCCC[C@@H]3N)n3ccnc3c2C(N)=O)c1
Show InChI InChI=1S/C26H29N7O/c1-16-6-4-7-17(14-16)18-8-5-9-19(15-18)30-24-22(23(28)34)25-29-12-13-33(25)26(32-24)31-21-11-3-2-10-20(21)27/h4-9,12-15,20-21,30H,2-3,10-11,27H2,1H3,(H2,28,34)(H,31,32)/t20-,21+/m0/s1
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Ziarco Pharma Ltd.

US Patent


Assay Description
The Promega ADP-Glo Kinase Assay is a luminescent ADP detection assay that provides a universal, homogeneous, high-throughput screening method to mea...

US Patent US9533989 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ31M7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM260756
PNG
(US9533989, 67)
Show SMILES COc1cccc(c1)C(=O)N1CCc2ccc(Nc3nc(N[C@@H]4CCCC[C@@H]4N)ncc3C(N)=O)cc2C1
Show InChI InChI=1S/C28H33N7O3/c1-38-21-6-4-5-18(14-21)27(37)35-12-11-17-9-10-20(13-19(17)16-35)32-26-22(25(30)36)15-31-28(34-26)33-24-8-3-2-7-23(24)29/h4-6,9-10,13-15,23-24H,2-3,7-8,11-12,16,29H2,1H3,(H2,30,36)(H2,31,32,33,34)/t23-,24+/m0/s1
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Ziarco Pharma Ltd.

US Patent


Assay Description
The Promega ADP-Glo Kinase Assay is a luminescent ADP detection assay that provides a universal, homogeneous, high-throughput screening method to mea...

US Patent US9533989 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ31M7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM260757
PNG
(US9533989, 68)
Show SMILES CCc1cccc(c1)C(=O)N1CCc2ccc(Nc3nc(N[C@@H]4CCCC[C@@H]4N)ncc3C(N)=O)cc2C1
Show InChI InChI=1S/C29H35N7O2/c1-2-18-6-5-7-20(14-18)28(38)36-13-12-19-10-11-22(15-21(19)17-36)33-27-23(26(31)37)16-32-29(35-27)34-25-9-4-3-8-24(25)30/h5-7,10-11,14-16,24-25H,2-4,8-9,12-13,17,30H2,1H3,(H2,31,37)(H2,32,33,34,35)/t24-,25+/m0/s1
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Ziarco Pharma Ltd.

US Patent


Assay Description
The Promega ADP-Glo Kinase Assay is a luminescent ADP detection assay that provides a universal, homogeneous, high-throughput screening method to mea...

US Patent US9533989 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ31M7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM260758
PNG
(US9533989, 69)
Show SMILES N[C@H]1CCCC[C@H]1Nc1ncc(C(N)=O)c(Nc2ccc3CCN(Cc3c2)C(=O)C2CCCCC2)n1
Show InChI InChI=1S/C27H37N7O2/c28-22-8-4-5-9-23(22)32-27-30-15-21(24(29)35)25(33-27)31-20-11-10-17-12-13-34(16-19(17)14-20)26(36)18-6-2-1-3-7-18/h10-11,14-15,18,22-23H,1-9,12-13,16,28H2,(H2,29,35)(H2,30,31,32,33)/t22-,23+/m0/s1
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Ziarco Pharma Ltd.

US Patent


Assay Description
The Promega ADP-Glo Kinase Assay is a luminescent ADP detection assay that provides a universal, homogeneous, high-throughput screening method to mea...

US Patent US9533989 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ31M7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM260759
PNG
(US9533989, 70)
Show SMILES CC(C)S(=O)(=O)N1CCc2ccc(Nc3nc(N[C@@H]4CCCC[C@@H]4N)ncc3C(N)=O)cc2C1
Show InChI InChI=1S/C23H33N7O3S/c1-14(2)34(32,33)30-10-9-15-7-8-17(11-16(15)13-30)27-22-18(21(25)31)12-26-23(29-22)28-20-6-4-3-5-19(20)24/h7-8,11-12,14,19-20H,3-6,9-10,13,24H2,1-2H3,(H2,25,31)(H2,26,27,28,29)/t19-,20+/m0/s1
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Ziarco Pharma Ltd.

US Patent


Assay Description
The Promega ADP-Glo Kinase Assay is a luminescent ADP detection assay that provides a universal, homogeneous, high-throughput screening method to mea...

US Patent US9533989 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ31M7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM260760
PNG
(US9533989, 71)
Show SMILES COc1ccccc1C(=O)N1CCc2ccc(Nc3nc(N[C@@H]4CCCC[C@@H]4N)ncc3C(N)=O)cc2C1
Show InChI InChI=1S/C28H33N7O3/c1-38-24-9-5-2-6-20(24)27(37)35-13-12-17-10-11-19(14-18(17)16-35)32-26-21(25(30)36)15-31-28(34-26)33-23-8-4-3-7-22(23)29/h2,5-6,9-11,14-15,22-23H,3-4,7-8,12-13,16,29H2,1H3,(H2,30,36)(H2,31,32,33,34)/t22-,23+/m0/s1
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Ziarco Pharma Ltd.

US Patent


Assay Description
The Promega ADP-Glo Kinase Assay is a luminescent ADP detection assay that provides a universal, homogeneous, high-throughput screening method to mea...

US Patent US9533989 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ31M7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM260761
PNG
(US9533989, 72)
Show SMILES Cc1ccc(cc1)C(=O)N1CCc2ccc(Nc3nc(N[C@@H]4CCCC[C@@H]4N)ncc3C(N)=O)cc2C1
Show InChI InChI=1S/C28H33N7O2/c1-17-6-8-19(9-7-17)27(37)35-13-12-18-10-11-21(14-20(18)16-35)32-26-22(25(30)36)15-31-28(34-26)33-24-5-3-2-4-23(24)29/h6-11,14-15,23-24H,2-5,12-13,16,29H2,1H3,(H2,30,36)(H2,31,32,33,34)/t23-,24+/m0/s1
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Ziarco Pharma Ltd.

US Patent


Assay Description
The Promega ADP-Glo Kinase Assay is a luminescent ADP detection assay that provides a universal, homogeneous, high-throughput screening method to mea...

US Patent US9533989 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ31M7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM260762
PNG
(US9533989, 73)
Show SMILES N[C@H]1CCCC[C@H]1Nc1ncc(C(N)=O)c(Nc2ccc3CCN(Cc3c2)C(=O)c2ccccc2Cl)n1
Show InChI InChI=1S/C27H30ClN7O2/c28-21-6-2-1-5-19(21)26(37)35-12-11-16-9-10-18(13-17(16)15-35)32-25-20(24(30)36)14-31-27(34-25)33-23-8-4-3-7-22(23)29/h1-2,5-6,9-10,13-14,22-23H,3-4,7-8,11-12,15,29H2,(H2,30,36)(H2,31,32,33,34)/t22-,23+/m0/s1
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Ziarco Pharma Ltd.

US Patent


Assay Description
The Promega ADP-Glo Kinase Assay is a luminescent ADP detection assay that provides a universal, homogeneous, high-throughput screening method to mea...

US Patent US9533989 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ31M7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM260763
PNG
(US9533989, 74)
Show SMILES N[C@H]1CCCC[C@H]1Nc1ncc(C(N)=O)c(Nc2cccc3n(Cc4ccccc4Cl)ccc23)n1
Show InChI InChI=1S/C26H28ClN7O/c27-19-7-2-1-6-16(19)15-34-13-12-17-21(10-5-11-23(17)34)31-25-18(24(29)35)14-30-26(33-25)32-22-9-4-3-8-20(22)28/h1-2,5-7,10-14,20,22H,3-4,8-9,15,28H2,(H2,29,35)(H2,30,31,32,33)/t20-,22+/m0/s1
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Ziarco Pharma Ltd.

US Patent


Assay Description
The Promega ADP-Glo Kinase Assay is a luminescent ADP detection assay that provides a universal, homogeneous, high-throughput screening method to mea...

US Patent US9533989 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ31M7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM260764
PNG
(US9533989, 75)
Show SMILES N[C@H]1CCCC[C@H]1Nc1ncc(C(N)=O)c(Nc2ccc3CCN(Cc3c2)C(=O)c2ccccc2F)n1
Show InChI InChI=1S/C27H30FN7O2/c28-21-6-2-1-5-19(21)26(37)35-12-11-16-9-10-18(13-17(16)15-35)32-25-20(24(30)36)14-31-27(34-25)33-23-8-4-3-7-22(23)29/h1-2,5-6,9-10,13-14,22-23H,3-4,7-8,11-12,15,29H2,(H2,30,36)(H2,31,32,33,34)/t22-,23+/m0/s1
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Ziarco Pharma Ltd.

US Patent


Assay Description
The Promega ADP-Glo Kinase Assay is a luminescent ADP detection assay that provides a universal, homogeneous, high-throughput screening method to mea...

US Patent US9533989 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ31M7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM260765
PNG
(US9533989, 76)
Show SMILES N[C@H]1CCCC[C@H]1Nc1ncc(C(N)=O)c(Nc2cccc(COc3ccccc3)c2)n1
Show InChI InChI=1S/C24H28N6O2/c25-20-11-4-5-12-21(20)29-24-27-14-19(22(26)31)23(30-24)28-17-8-6-7-16(13-17)15-32-18-9-2-1-3-10-18/h1-3,6-10,13-14,20-21H,4-5,11-12,15,25H2,(H2,26,31)(H2,27,28,29,30)/t20-,21+/m0/s1
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Ziarco Pharma Ltd.

US Patent


Assay Description
The Promega ADP-Glo Kinase Assay is a luminescent ADP detection assay that provides a universal, homogeneous, high-throughput screening method to mea...

US Patent US9533989 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ31M7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM260766
PNG
(US9533989, 77)
Show SMILES N[C@H]1CCCC[C@H]1Nc1ncc(C(N)=O)c(Nc2ccc3CCN(Cc3c2)C(=O)c2ccc(Cl)cc2)n1
Show InChI InChI=1S/C27H30ClN7O2/c28-19-8-5-17(6-9-19)26(37)35-12-11-16-7-10-20(13-18(16)15-35)32-25-21(24(30)36)14-31-27(34-25)33-23-4-2-1-3-22(23)29/h5-10,13-14,22-23H,1-4,11-12,15,29H2,(H2,30,36)(H2,31,32,33,34)/t22-,23+/m0/s1
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Ziarco Pharma Ltd.

US Patent


Assay Description
The Promega ADP-Glo Kinase Assay is a luminescent ADP detection assay that provides a universal, homogeneous, high-throughput screening method to mea...

US Patent US9533989 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ31M7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM260767
PNG
(US9533989, 78)
Show SMILES N[C@H]1CCCC[C@H]1Nc1ncc(C(N)=O)c(Nc2ccc3CCN(Cc3c2)C(=O)C2CCCC2)n1
Show InChI InChI=1S/C26H35N7O2/c27-21-7-3-4-8-22(21)31-26-29-14-20(23(28)34)24(32-26)30-19-10-9-16-11-12-33(15-18(16)13-19)25(35)17-5-1-2-6-17/h9-10,13-14,17,21-22H,1-8,11-12,15,27H2,(H2,28,34)(H2,29,30,31,32)/t21-,22+/m0/s1
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Ziarco Pharma Ltd.

US Patent


Assay Description
The Promega ADP-Glo Kinase Assay is a luminescent ADP detection assay that provides a universal, homogeneous, high-throughput screening method to mea...

US Patent US9533989 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ31M7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM260768
PNG
(US9533989, 79)
Show SMILES N[C@H]1CCCC[C@H]1Nc1ncc(C(N)=O)c(Nc2cccc3n(Cc4cccc(Cl)c4)ccc23)n1
Show InChI InChI=1S/C26H28ClN7O/c27-17-6-3-5-16(13-17)15-34-12-11-18-21(9-4-10-23(18)34)31-25-19(24(29)35)14-30-26(33-25)32-22-8-2-1-7-20(22)28/h3-6,9-14,20,22H,1-2,7-8,15,28H2,(H2,29,35)(H2,30,31,32,33)/t20-,22+/m0/s1
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Ziarco Pharma Ltd.

US Patent


Assay Description
The Promega ADP-Glo Kinase Assay is a luminescent ADP detection assay that provides a universal, homogeneous, high-throughput screening method to mea...

US Patent US9533989 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ31M7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM260769
PNG
(US9533989, 80)
Show SMILES Cc1cccc(c1)C(=O)N1CCc2ccc(Nc3nc(N[C@@H]4CCCC[C@@H]4N)ncc3C(N)=O)cc2C1
Show InChI InChI=1S/C28H33N7O2/c1-17-5-4-6-19(13-17)27(37)35-12-11-18-9-10-21(14-20(18)16-35)32-26-22(25(30)36)15-31-28(34-26)33-24-8-3-2-7-23(24)29/h4-6,9-10,13-15,23-24H,2-3,7-8,11-12,16,29H2,1H3,(H2,30,36)(H2,31,32,33,34)/t23-,24+/m0/s1
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Ziarco Pharma Ltd.

US Patent


Assay Description
The Promega ADP-Glo Kinase Assay is a luminescent ADP detection assay that provides a universal, homogeneous, high-throughput screening method to mea...

US Patent US9533989 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ31M7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM260770
PNG
(US9533989, 81)
Show SMILES N[C@H]1CCCC[C@H]1Nc1ncc(C(N)=O)c(Nc2ccc3CCN(Cc3c2)C(=O)C2CC2)n1
Show InChI InChI=1S/C24H31N7O2/c25-19-3-1-2-4-20(19)29-24-27-12-18(21(26)32)22(30-24)28-17-8-7-14-9-10-31(13-16(14)11-17)23(33)15-5-6-15/h7-8,11-12,15,19-20H,1-6,9-10,13,25H2,(H2,26,32)(H2,27,28,29,30)/t19-,20+/m0/s1
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Ziarco Pharma Ltd.

US Patent


Assay Description
The Promega ADP-Glo Kinase Assay is a luminescent ADP detection assay that provides a universal, homogeneous, high-throughput screening method to mea...

US Patent US9533989 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ31M7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM260771
PNG
(US9533989, 82)
Show SMILES CSc1ccc(cc1)C(=O)N1CCc2ccc(Nc3nc(N[C@@H]4CCCC[C@@H]4N)ncc3C(N)=O)cc2C1
Show InChI InChI=1S/C28H33N7O2S/c1-38-21-10-7-18(8-11-21)27(37)35-13-12-17-6-9-20(14-19(17)16-35)32-26-22(25(30)36)15-31-28(34-26)33-24-5-3-2-4-23(24)29/h6-11,14-15,23-24H,2-5,12-13,16,29H2,1H3,(H2,30,36)(H2,31,32,33,34)/t23-,24+/m0/s1
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Ziarco Pharma Ltd.

US Patent


Assay Description
The Promega ADP-Glo Kinase Assay is a luminescent ADP detection assay that provides a universal, homogeneous, high-throughput screening method to mea...

US Patent US9533989 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ31M7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM260772
PNG
(US9533989, 83)
Show SMILES CCc1ccc(cc1)C(=O)N1CCc2ccc(Nc3nc(N[C@@H]4CCCC[C@@H]4N)ncc3C(N)=O)cc2C1
Show InChI InChI=1S/C29H35N7O2/c1-2-18-7-9-20(10-8-18)28(38)36-14-13-19-11-12-22(15-21(19)17-36)33-27-23(26(31)37)16-32-29(35-27)34-25-6-4-3-5-24(25)30/h7-12,15-16,24-25H,2-6,13-14,17,30H2,1H3,(H2,31,37)(H2,32,33,34,35)/t24-,25+/m0/s1
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n/an/a 40.6n/an/an/an/an/an/a



Ziarco Pharma Ltd.

US Patent


Assay Description
The Promega ADP-Glo Kinase Assay is a luminescent ADP detection assay that provides a universal, homogeneous, high-throughput screening method to mea...

US Patent US9533989 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ31M7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM260773
PNG
(US9533989, 84)
Show SMILES COc1cccc(Cn2ccc3ccc(Nc4nc(N[C@@H]5CCCC[C@@H]5N)ncc4C(N)=O)cc23)c1
Show InChI InChI=1S/C27H31N7O2/c1-36-20-6-4-5-17(13-20)16-34-12-11-18-9-10-19(14-24(18)34)31-26-21(25(29)35)15-30-27(33-26)32-23-8-3-2-7-22(23)28/h4-6,9-15,22-23H,2-3,7-8,16,28H2,1H3,(H2,29,35)(H2,30,31,32,33)/t22-,23+/m0/s1
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Ziarco Pharma Ltd.

US Patent


Assay Description
The Promega ADP-Glo Kinase Assay is a luminescent ADP detection assay that provides a universal, homogeneous, high-throughput screening method to mea...

US Patent US9533989 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ31M7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM260774
PNG
(US9533989, 85)
Show SMILES COc1ccc(Cn2ccc3ccc(Nc4nc(N[C@@H]5CCCC[C@@H]5N)ncc4C(N)=O)cc23)cc1
Show InChI InChI=1S/C27H31N7O2/c1-36-20-10-6-17(7-11-20)16-34-13-12-18-8-9-19(14-24(18)34)31-26-21(25(29)35)15-30-27(33-26)32-23-5-3-2-4-22(23)28/h6-15,22-23H,2-5,16,28H2,1H3,(H2,29,35)(H2,30,31,32,33)/t22-,23+/m0/s1
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Ziarco Pharma Ltd.

US Patent


Assay Description
The Promega ADP-Glo Kinase Assay is a luminescent ADP detection assay that provides a universal, homogeneous, high-throughput screening method to mea...

US Patent US9533989 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ31M7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM260775
PNG
(US9533989, 86)
Show SMILES COc1ccc(Cc2cccc(Nc3nc(N[C@@H]4CCCC[C@@H]4N)ncc3C(N)=O)c2)cc1
Show InChI InChI=1S/C25H30N6O2/c1-33-19-11-9-16(10-12-19)13-17-5-4-6-18(14-17)29-24-20(23(27)32)15-28-25(31-24)30-22-8-3-2-7-21(22)26/h4-6,9-12,14-15,21-22H,2-3,7-8,13,26H2,1H3,(H2,27,32)(H2,28,29,30,31)/t21-,22+/m0/s1
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Ziarco Pharma Ltd.

US Patent


Assay Description
The Promega ADP-Glo Kinase Assay is a luminescent ADP detection assay that provides a universal, homogeneous, high-throughput screening method to mea...

US Patent US9533989 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ31M7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM260776
PNG
(US9533989, 87)
Show SMILES COc1ccccc1Cn1ccc2ccc(Nc3nc(N[C@@H]4CCCC[C@@H]4N)ncc3C(N)=O)cc12
Show InChI InChI=1S/C27H31N7O2/c1-36-24-9-5-2-6-18(24)16-34-13-12-17-10-11-19(14-23(17)34)31-26-20(25(29)35)15-30-27(33-26)32-22-8-4-3-7-21(22)28/h2,5-6,9-15,21-22H,3-4,7-8,16,28H2,1H3,(H2,29,35)(H2,30,31,32,33)/t21-,22+/m0/s1
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n/an/a 45.8n/an/an/an/an/an/a



Ziarco Pharma Ltd.

US Patent


Assay Description
The Promega ADP-Glo Kinase Assay is a luminescent ADP detection assay that provides a universal, homogeneous, high-throughput screening method to mea...

US Patent US9533989 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ31M7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM260777
PNG
(US9533989, 88)
Show SMILES CCc1ccccc1C(=O)N1CCc2ccc(Nc3nc(N[C@@H]4CCCC[C@@H]4N)ncc3C(N)=O)cc2C1
Show InChI InChI=1S/C29H35N7O2/c1-2-18-7-3-4-8-22(18)28(38)36-14-13-19-11-12-21(15-20(19)17-36)33-27-23(26(31)37)16-32-29(35-27)34-25-10-6-5-9-24(25)30/h3-4,7-8,11-12,15-16,24-25H,2,5-6,9-10,13-14,17,30H2,1H3,(H2,31,37)(H2,32,33,34,35)/t24-,25+/m0/s1
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n/an/a 48.4n/an/an/an/an/an/a



Ziarco Pharma Ltd.

US Patent


Assay Description
The Promega ADP-Glo Kinase Assay is a luminescent ADP detection assay that provides a universal, homogeneous, high-throughput screening method to mea...

US Patent US9533989 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ31M7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM260778
PNG
(US9533989, 89)
Show SMILES N[C@H]1CCCC[C@H]1Nc1ncc(C(N)=O)c(Nc2ccc3CCN(Cc3c2)C(=O)c2cccc(Cl)c2)n1
Show InChI InChI=1S/C27H30ClN7O2/c28-19-5-3-4-17(12-19)26(37)35-11-10-16-8-9-20(13-18(16)15-35)32-25-21(24(30)36)14-31-27(34-25)33-23-7-2-1-6-22(23)29/h3-5,8-9,12-14,22-23H,1-2,6-7,10-11,15,29H2,(H2,30,36)(H2,31,32,33,34)/t22-,23+/m0/s1
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n/an/a 48.6n/an/an/an/an/an/a



Ziarco Pharma Ltd.

US Patent


Assay Description
The Promega ADP-Glo Kinase Assay is a luminescent ADP detection assay that provides a universal, homogeneous, high-throughput screening method to mea...

US Patent US9533989 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ31M7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM260779
PNG
(US9533989, 90)
Show SMILES N[C@H]1CCCC[C@H]1Nc1ncc(C(N)=O)c(Nc2ccc3CCN(Cc3c2)C(=O)c2ccccn2)n1
Show InChI InChI=1S/C26H30N8O2/c27-20-5-1-2-6-21(20)32-26-30-14-19(23(28)35)24(33-26)31-18-9-8-16-10-12-34(15-17(16)13-18)25(36)22-7-3-4-11-29-22/h3-4,7-9,11,13-14,20-21H,1-2,5-6,10,12,15,27H2,(H2,28,35)(H2,30,31,32,33)/t20-,21+/m0/s1
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n/an/a 48.9n/an/an/an/an/an/a



Ziarco Pharma Ltd.

US Patent


Assay Description
The Promega ADP-Glo Kinase Assay is a luminescent ADP detection assay that provides a universal, homogeneous, high-throughput screening method to mea...

US Patent US9533989 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ31M7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM260780
PNG
(US9533989, 91)
Show SMILES N[C@H]1CCCC[C@H]1Nc1ncc(C(N)=O)c(Nc2cccc3n(Cc4cccc(Oc5ccccc5)c4)ccc23)n1
Show InChI InChI=1S/C32H33N7O2/c33-26-12-4-5-13-28(26)37-32-35-19-25(30(34)40)31(38-32)36-27-14-7-15-29-24(27)16-17-39(29)20-21-8-6-11-23(18-21)41-22-9-2-1-3-10-22/h1-3,6-11,14-19,26,28H,4-5,12-13,20,33H2,(H2,34,40)(H2,35,36,37,38)/t26-,28+/m0/s1
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n/an/a 55.1n/an/an/an/an/an/a



Ziarco Pharma Ltd.

US Patent


Assay Description
The Promega ADP-Glo Kinase Assay is a luminescent ADP detection assay that provides a universal, homogeneous, high-throughput screening method to mea...

US Patent US9533989 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ31M7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM260781
PNG
(US9533989, 92)
Show SMILES COc1ccc(cc1)C(=O)N1CCc2ccc(Nc3nc(N[C@@H]4CCCC[C@@H]4N)ncc3C(N)=O)cc2C1
Show InChI InChI=1S/C28H33N7O3/c1-38-21-10-7-18(8-11-21)27(37)35-13-12-17-6-9-20(14-19(17)16-35)32-26-22(25(30)36)15-31-28(34-26)33-24-5-3-2-4-23(24)29/h6-11,14-15,23-24H,2-5,12-13,16,29H2,1H3,(H2,30,36)(H2,31,32,33,34)/t23-,24+/m0/s1
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Ziarco Pharma Ltd.

US Patent


Assay Description
The Promega ADP-Glo Kinase Assay is a luminescent ADP detection assay that provides a universal, homogeneous, high-throughput screening method to mea...

US Patent US9533989 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ31M7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM260782
PNG
(US9533989, 93)
Show SMILES Cc1cccc(Nc2nc(N[C@@H]3CCCC[C@@H]3N)nc3cc[nH]c(=O)c23)c1
Show InChI InChI=1S/C20H24N6O/c1-12-5-4-6-13(11-12)23-18-17-16(9-10-22-19(17)27)25-20(26-18)24-15-8-3-2-7-14(15)21/h4-6,9-11,14-15H,2-3,7-8,21H2,1H3,(H,22,27)(H2,23,24,25,26)/t14-,15+/m0/s1
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n/an/a 60.9n/an/an/an/an/an/a



Ziarco Pharma Ltd.

US Patent


Assay Description
The Promega ADP-Glo Kinase Assay is a luminescent ADP detection assay that provides a universal, homogeneous, high-throughput screening method to mea...

US Patent US9533989 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ31M7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM260783
PNG
(US9533989, 94)
Show SMILES CSc1ccccc1C(=O)N1CCc2ccc(Nc3nc(N[C@@H]4CCCC[C@@H]4N)ncc3C(N)=O)cc2C1
Show InChI InChI=1S/C28H33N7O2S/c1-38-24-9-5-2-6-20(24)27(37)35-13-12-17-10-11-19(14-18(17)16-35)32-26-21(25(30)36)15-31-28(34-26)33-23-8-4-3-7-22(23)29/h2,5-6,9-11,14-15,22-23H,3-4,7-8,12-13,16,29H2,1H3,(H2,30,36)(H2,31,32,33,34)/t22-,23+/m0/s1
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n/an/a 61.3n/an/an/an/an/an/a



Ziarco Pharma Ltd.

US Patent


Assay Description
The Promega ADP-Glo Kinase Assay is a luminescent ADP detection assay that provides a universal, homogeneous, high-throughput screening method to mea...

US Patent US9533989 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ31M7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM260784
PNG
(US9533989, 95)
Show SMILES N[C@H]1CCCC[C@H]1Nc1ncc(C(N)=O)c(Nc2cccc(Cc3ccc(Cl)cc3)c2)n1
Show InChI InChI=1S/C24H27ClN6O/c25-17-10-8-15(9-11-17)12-16-4-3-5-18(13-16)29-23-19(22(27)32)14-28-24(31-23)30-21-7-2-1-6-20(21)26/h3-5,8-11,13-14,20-21H,1-2,6-7,12,26H2,(H2,27,32)(H2,28,29,30,31)/t20-,21+/m0/s1
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n/an/a 69.9n/an/an/an/an/an/a



Ziarco Pharma Ltd.

US Patent


Assay Description
The Promega ADP-Glo Kinase Assay is a luminescent ADP detection assay that provides a universal, homogeneous, high-throughput screening method to mea...

US Patent US9533989 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ31M7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM260785
PNG
(US9533989, 96)
Show SMILES N[C@H]1CCCC[C@H]1Nc1ncc(C(N)=O)c(Nc2cccc3n(Cc4ccc(cc4)-c4ccccc4)ccc23)n1
Show InChI InChI=1S/C32H33N7O/c33-26-9-4-5-10-28(26)37-32-35-19-25(30(34)40)31(38-32)36-27-11-6-12-29-24(27)17-18-39(29)20-21-13-15-23(16-14-21)22-7-2-1-3-8-22/h1-3,6-8,11-19,26,28H,4-5,9-10,20,33H2,(H2,34,40)(H2,35,36,37,38)/t26-,28+/m0/s1
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n/an/a 72.4n/an/an/an/an/an/a



Ziarco Pharma Ltd.

US Patent


Assay Description
The Promega ADP-Glo Kinase Assay is a luminescent ADP detection assay that provides a universal, homogeneous, high-throughput screening method to mea...

US Patent US9533989 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ31M7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM260786
PNG
(US9533989, 97)
Show SMILES N[C@H]1CCCC[C@H]1Nc1ncc(C(N)=O)c(Nc2ccc3CCN(Cc4ccccc4)Cc3c2)n1
Show InChI InChI=1S/C27H33N7O/c28-23-8-4-5-9-24(23)32-27-30-15-22(25(29)35)26(33-27)31-21-11-10-19-12-13-34(17-20(19)14-21)16-18-6-2-1-3-7-18/h1-3,6-7,10-11,14-15,23-24H,4-5,8-9,12-13,16-17,28H2,(H2,29,35)(H2,30,31,32,33)/t23-,24+/m0/s1
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n/an/a 72.6n/an/an/an/an/an/a



Ziarco Pharma Ltd.

US Patent


Assay Description
The Promega ADP-Glo Kinase Assay is a luminescent ADP detection assay that provides a universal, homogeneous, high-throughput screening method to mea...

US Patent US9533989 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ31M7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM260787
PNG
(US9533989, 98)
Show SMILES N[C@H]1CCCC[C@H]1Nc1ncc(C(N)=O)c(Nc2cccc(Sc3cccc(O)c3)c2)n1
Show InChI InChI=1S/C23H26N6O2S/c24-19-9-1-2-10-20(19)28-23-26-13-18(21(25)31)22(29-23)27-14-5-3-7-16(11-14)32-17-8-4-6-15(30)12-17/h3-8,11-13,19-20,30H,1-2,9-10,24H2,(H2,25,31)(H2,26,27,28,29)/t19-,20+/m0/s1
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Ziarco Pharma Ltd.

US Patent


Assay Description
The Promega ADP-Glo Kinase Assay is a luminescent ADP detection assay that provides a universal, homogeneous, high-throughput screening method to mea...

US Patent US9533989 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ31M7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM260788
PNG
(US9533989, 99)
Show SMILES N[C@H]1CCCC[C@H]1Nc1ncc(C(N)=O)c(Nc2cccc(Sc3ccc(O)cc3)c2)n1
Show InChI InChI=1S/C23H26N6O2S/c24-19-6-1-2-7-20(19)28-23-26-13-18(21(25)31)22(29-23)27-14-4-3-5-17(12-14)32-16-10-8-15(30)9-11-16/h3-5,8-13,19-20,30H,1-2,6-7,24H2,(H2,25,31)(H2,26,27,28,29)/t19-,20+/m0/s1
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n/an/a 74.5n/an/an/an/an/an/a



Ziarco Pharma Ltd.

US Patent


Assay Description
The Promega ADP-Glo Kinase Assay is a luminescent ADP detection assay that provides a universal, homogeneous, high-throughput screening method to mea...

US Patent US9533989 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ31M7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM260789
PNG
(US9533989, 100)
Show SMILES COc1ccc(Sc2cccc(Nc3nc(N[C@@H]4CCCC[C@@H]4N)ncc3C(N)=O)c2)cc1
Show InChI InChI=1S/C24H28N6O2S/c1-32-16-9-11-17(12-10-16)33-18-6-4-5-15(13-18)28-23-19(22(26)31)14-27-24(30-23)29-21-8-3-2-7-20(21)25/h4-6,9-14,20-21H,2-3,7-8,25H2,1H3,(H2,26,31)(H2,27,28,29,30)/t20-,21+/m0/s1
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Ziarco Pharma Ltd.

US Patent


Assay Description
The Promega ADP-Glo Kinase Assay is a luminescent ADP detection assay that provides a universal, homogeneous, high-throughput screening method to mea...

US Patent US9533989 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ31M7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM260790
PNG
(US9533989, 101)
Show SMILES Cc1ccccc1C(=O)N1CCc2ccc(Nc3nc(N[C@@H]4CCCC[C@@H]4N)ncc3C(N)=O)cc2C1
Show InChI InChI=1S/C28H33N7O2/c1-17-6-2-3-7-21(17)27(37)35-13-12-18-10-11-20(14-19(18)16-35)32-26-22(25(30)36)15-31-28(34-26)33-24-9-5-4-8-23(24)29/h2-3,6-7,10-11,14-15,23-24H,4-5,8-9,12-13,16,29H2,1H3,(H2,30,36)(H2,31,32,33,34)/t23-,24+/m0/s1
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n/an/a 78.4n/an/an/an/an/an/a



Ziarco Pharma Ltd.

US Patent


Assay Description
The Promega ADP-Glo Kinase Assay is a luminescent ADP detection assay that provides a universal, homogeneous, high-throughput screening method to mea...

US Patent US9533989 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ31M7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM260791
PNG
(US9533989, 102)
Show SMILES N[C@H]1CCCC[C@H]1Nc1ncc(C(N)=O)c(Nc2ccc3ccn(Cc4ccc(O)cc4)c3c2)n1
Show InChI InChI=1S/C26H29N7O2/c27-21-3-1-2-4-22(21)31-26-29-14-20(24(28)35)25(32-26)30-18-8-7-17-11-12-33(23(17)13-18)15-16-5-9-19(34)10-6-16/h5-14,21-22,34H,1-4,15,27H2,(H2,28,35)(H2,29,30,31,32)/t21-,22+/m0/s1
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n/an/a 94.9n/an/an/an/an/an/a



Ziarco Pharma Ltd.

US Patent


Assay Description
The Promega ADP-Glo Kinase Assay is a luminescent ADP detection assay that provides a universal, homogeneous, high-throughput screening method to mea...

US Patent US9533989 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ31M7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM260792
PNG
(US9533989, 103)
Show SMILES Cc1cccc(Cc2cccc(Nc3nc(N[C@@H]4CCCC[C@@H]4N)ncc3C(N)=O)c2)c1
Show InChI InChI=1S/C25H30N6O/c1-16-6-4-7-17(12-16)13-18-8-5-9-19(14-18)29-24-20(23(27)32)15-28-25(31-24)30-22-11-3-2-10-21(22)26/h4-9,12,14-15,21-22H,2-3,10-11,13,26H2,1H3,(H2,27,32)(H2,28,29,30,31)/t21-,22+/m0/s1
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Ziarco Pharma Ltd.

US Patent


Assay Description
The Promega ADP-Glo Kinase Assay is a luminescent ADP detection assay that provides a universal, homogeneous, high-throughput screening method to mea...

US Patent US9533989 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ31M7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM260793
PNG
(US9533989, 104)
Show SMILES CNC(=O)COc1cccc(Nc2nc(N[C@@H]3CCCC[C@@H]3N)ncc2C(N)=O)c1
Show InChI InChI=1S/C20H27N7O3/c1-23-17(28)11-30-13-6-4-5-12(9-13)25-19-14(18(22)29)10-24-20(27-19)26-16-8-3-2-7-15(16)21/h4-6,9-10,15-16H,2-3,7-8,11,21H2,1H3,(H2,22,29)(H,23,28)(H2,24,25,26,27)/t15-,16+/m0/s1
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Ziarco Pharma Ltd.

US Patent


Assay Description
The Promega ADP-Glo Kinase Assay is a luminescent ADP detection assay that provides a universal, homogeneous, high-throughput screening method to mea...

US Patent US9533989 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ31M7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM260794
PNG
(US9533989, 105)
Show SMILES N[C@H]1CCCC[C@H]1Nc1ncc(C(N)=O)c(Nc2ccc3CCCN(C(=O)C4CC4)c3c2)n1
Show InChI InChI=1S/C24H31N7O2/c25-18-5-1-2-6-19(18)29-24-27-13-17(21(26)32)22(30-24)28-16-10-9-14-4-3-11-31(20(14)12-16)23(33)15-7-8-15/h9-10,12-13,15,18-19H,1-8,11,25H2,(H2,26,32)(H2,27,28,29,30)/t18-,19+/m0/s1
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Ziarco Pharma Ltd.

US Patent


Assay Description
The Promega ADP-Glo Kinase Assay is a luminescent ADP detection assay that provides a universal, homogeneous, high-throughput screening method to mea...

US Patent US9533989 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ31M7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM260795
PNG
(US9533989, 106)
Show SMILES N[C@H]1CCCC[C@H]1Nc1ncc(C(N)=O)c(Nc2cccc(Sc3ccc(Cl)cc3)c2)n1
Show InChI InChI=1S/C23H25ClN6OS/c24-14-8-10-16(11-9-14)32-17-5-3-4-15(12-17)28-22-18(21(26)31)13-27-23(30-22)29-20-7-2-1-6-19(20)25/h3-5,8-13,19-20H,1-2,6-7,25H2,(H2,26,31)(H2,27,28,29,30)/t19-,20+/m0/s1
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Ziarco Pharma Ltd.

US Patent


Assay Description
The Promega ADP-Glo Kinase Assay is a luminescent ADP detection assay that provides a universal, homogeneous, high-throughput screening method to mea...

US Patent US9533989 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ31M7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM260796
PNG
(US9533989, 107)
Show SMILES COc1cc(Nc2nc(N[C@@H]3CCCC[C@@H]3N)n3ccnc3c2C(N)=O)ccc1-c1cccc(C)c1
Show InChI InChI=1S/C27H31N7O2/c1-16-6-5-7-17(14-16)19-11-10-18(15-22(19)36-2)31-25-23(24(29)35)26-30-12-13-34(26)27(33-25)32-21-9-4-3-8-20(21)28/h5-7,10-15,20-21,31H,3-4,8-9,28H2,1-2H3,(H2,29,35)(H,32,33)/t20-,21+/m0/s1
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Ziarco Pharma Ltd.

US Patent


Assay Description
The Promega ADP-Glo Kinase Assay is a luminescent ADP detection assay that provides a universal, homogeneous, high-throughput screening method to mea...

US Patent US9533989 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ31M7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM260718
PNG
(US9533989, 108 | US9533989, 28)
Show SMILES N[C@H]1CCCC[C@H]1Nc1ncc(C(N)=O)c(Nc2cccc3n(Cc4ccc(O)cc4)ccc23)n1
Show InChI InChI=1S/C26H29N7O2/c27-20-4-1-2-5-22(20)31-26-29-14-19(24(28)35)25(32-26)30-21-6-3-7-23-18(21)12-13-33(23)15-16-8-10-17(34)11-9-16/h3,6-14,20,22,34H,1-2,4-5,15,27H2,(H2,28,35)(H2,29,30,31,32)/t20-,22+/m0/s1
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Ziarco Pharma Ltd.

US Patent


Assay Description
The Promega ADP-Glo Kinase Assay is a luminescent ADP detection assay that provides a universal, homogeneous, high-throughput screening method to mea...

US Patent US9533989 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ31M7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM260798
PNG
(US9533989, 109)
Show SMILES N[C@H]1CCCC[C@H]1Nc1ncc(C(N)=O)c(Nc2ccc3CCN(Cc3c2)S(=O)(=O)c2ccccc2)n1
Show InChI InChI=1S/C26H31N7O3S/c27-22-8-4-5-9-23(22)31-26-29-15-21(24(28)34)25(32-26)30-19-11-10-17-12-13-33(16-18(17)14-19)37(35,36)20-6-2-1-3-7-20/h1-3,6-7,10-11,14-15,22-23H,4-5,8-9,12-13,16,27H2,(H2,28,34)(H2,29,30,31,32)/t22-,23+/m0/s1
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Ziarco Pharma Ltd.

US Patent


Assay Description
The Promega ADP-Glo Kinase Assay is a luminescent ADP detection assay that provides a universal, homogeneous, high-throughput screening method to mea...

US Patent US9533989 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ31M7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM260799
PNG
(US9533989, 110)
Show SMILES CN1CCc2ccc(Nc3nc(N[C@@H]4CCCC[C@@H]4N)ncc3C(N)=O)cc2C1
Show InChI InChI=1S/C21H29N7O/c1-28-9-8-13-6-7-15(10-14(13)12-28)25-20-16(19(23)29)11-24-21(27-20)26-18-5-3-2-4-17(18)22/h6-7,10-11,17-18H,2-5,8-9,12,22H2,1H3,(H2,23,29)(H2,24,25,26,27)/t17-,18+/m0/s1
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Ziarco Pharma Ltd.

US Patent


Assay Description
The Promega ADP-Glo Kinase Assay is a luminescent ADP detection assay that provides a universal, homogeneous, high-throughput screening method to mea...

US Patent US9533989 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ31M7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM260800
PNG
(US9533989, 111)
Show SMILES Cc1cccc(Sc2cccc(Nc3nc(N[C@@H]4CCCC[C@H]4N)ncc3C(N)=O)c2)c1
Show InChI InChI=1S/C24H28N6OS/c1-15-6-4-8-17(12-15)32-18-9-5-7-16(13-18)28-23-19(22(26)31)14-27-24(30-23)29-21-11-3-2-10-20(21)25/h4-9,12-14,20-21H,2-3,10-11,25H2,1H3,(H2,26,31)(H2,27,28,29,30)/t20-,21-/m1/s1
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Ziarco Pharma Ltd.

US Patent


Assay Description
The Promega ADP-Glo Kinase Assay is a luminescent ADP detection assay that provides a universal, homogeneous, high-throughput screening method to mea...

US Patent US9533989 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ31M7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM260801
PNG
(US9533989, 112)
Show SMILES COc1ccccc1Cn1ccc2cc(Nc3nc(N[C@@H]4CCCC[C@@H]4N)ncc3C(N)=O)ccc12
Show InChI InChI=1S/C27H31N7O2/c1-36-24-9-5-2-6-18(24)16-34-13-12-17-14-19(10-11-23(17)34)31-26-20(25(29)35)15-30-27(33-26)32-22-8-4-3-7-21(22)28/h2,5-6,9-15,21-22H,3-4,7-8,16,28H2,1H3,(H2,29,35)(H2,30,31,32,33)/t21-,22+/m0/s1
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Ziarco Pharma Ltd.

US Patent


Assay Description
The Promega ADP-Glo Kinase Assay is a luminescent ADP detection assay that provides a universal, homogeneous, high-throughput screening method to mea...

US Patent US9533989 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ31M7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM260802
PNG
(US9533989, 113)
Show SMILES COc1cccc(Sc2cccc(Nc3nc(N[C@@H]4CCCC[C@@H]4N)ncc3C(N)=O)c2)c1
Show InChI InChI=1S/C24H28N6O2S/c1-32-16-7-5-9-18(13-16)33-17-8-4-6-15(12-17)28-23-19(22(26)31)14-27-24(30-23)29-21-11-3-2-10-20(21)25/h4-9,12-14,20-21H,2-3,10-11,25H2,1H3,(H2,26,31)(H2,27,28,29,30)/t20-,21+/m0/s1
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Ziarco Pharma Ltd.

US Patent


Assay Description
The Promega ADP-Glo Kinase Assay is a luminescent ADP detection assay that provides a universal, homogeneous, high-throughput screening method to mea...

US Patent US9533989 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ31M7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM260803
PNG
(US9533989, 114)
Show SMILES N[C@H]1CCCC[C@H]1Nc1ncc(C(N)=O)c(Nc2cccc(Cc3ccccc3)c2)n1
Show InChI InChI=1S/C24H28N6O/c25-20-11-4-5-12-21(20)29-24-27-15-19(22(26)31)23(30-24)28-18-10-6-9-17(14-18)13-16-7-2-1-3-8-16/h1-3,6-10,14-15,20-21H,4-5,11-13,25H2,(H2,26,31)(H2,27,28,29,30)/t20-,21+/m0/s1
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Ziarco Pharma Ltd.

US Patent


Assay Description
The Promega ADP-Glo Kinase Assay is a luminescent ADP detection assay that provides a universal, homogeneous, high-throughput screening method to mea...

US Patent US9533989 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ31M7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM260804
PNG
(US9533989, 115)
Show SMILES Cc1nc(N[C@@H]2CCCC[C@@H]2N)nc(Nc2cccc(c2)-c2cccc(O)c2)c1C(N)=O
Show InChI InChI=1S/C24H28N6O2/c1-14-21(22(26)32)23(30-24(27-14)29-20-11-3-2-10-19(20)25)28-17-8-4-6-15(12-17)16-7-5-9-18(31)13-16/h4-9,12-13,19-20,31H,2-3,10-11,25H2,1H3,(H2,26,32)(H2,27,28,29,30)/t19-,20+/m0/s1
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Ziarco Pharma Ltd.

US Patent


Assay Description
The Promega ADP-Glo Kinase Assay is a luminescent ADP detection assay that provides a universal, homogeneous, high-throughput screening method to mea...

US Patent US9533989 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ31M7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM260805
PNG
(US9533989, 116)
Show SMILES N[C@H]1CCCC[C@H]1Nc1ncc(C(N)=O)c(Nc2cccc(Sc3ccccc3)c2)n1
Show InChI InChI=1S/C23H26N6OS/c24-19-11-4-5-12-20(19)28-23-26-14-18(21(25)30)22(29-23)27-15-7-6-10-17(13-15)31-16-8-2-1-3-9-16/h1-3,6-10,13-14,19-20H,4-5,11-12,24H2,(H2,25,30)(H2,26,27,28,29)/t19-,20+/m0/s1
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Ziarco Pharma Ltd.

US Patent


Assay Description
The Promega ADP-Glo Kinase Assay is a luminescent ADP detection assay that provides a universal, homogeneous, high-throughput screening method to mea...

US Patent US9533989 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ31M7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM260806
PNG
(US9533989, 117)
Show SMILES N[C@H]1CCCC[C@H]1Nc1ncc(C(N)=O)c(Nc2ccc(Cc3ccccc3)cc2)n1
Show InChI InChI=1S/C24H28N6O/c25-20-8-4-5-9-21(20)29-24-27-15-19(22(26)31)23(30-24)28-18-12-10-17(11-13-18)14-16-6-2-1-3-7-16/h1-3,6-7,10-13,15,20-21H,4-5,8-9,14,25H2,(H2,26,31)(H2,27,28,29,30)/t20-,21+/m0/s1
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Ziarco Pharma Ltd.

US Patent


Assay Description
The Promega ADP-Glo Kinase Assay is a luminescent ADP detection assay that provides a universal, homogeneous, high-throughput screening method to mea...

US Patent US9533989 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ31M7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM260807
PNG
(US9533989, 118)
Show SMILES N[C@H]1CCCC[C@H]1Nc1ncc(C(N)=O)c(Nc2ccc3CCNCc3c2)n1
Show InChI InChI=1S/C20H27N7O/c21-16-3-1-2-4-17(16)26-20-24-11-15(18(22)28)19(27-20)25-14-6-5-12-7-8-23-10-13(12)9-14/h5-6,9,11,16-17,23H,1-4,7-8,10,21H2,(H2,22,28)(H2,24,25,26,27)/t16-,17+/m0/s1
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Ziarco Pharma Ltd.

US Patent


Assay Description
The Promega ADP-Glo Kinase Assay is a luminescent ADP detection assay that provides a universal, homogeneous, high-throughput screening method to mea...

US Patent US9533989 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ31M7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM260808
PNG
(US9533989, 119)
Show SMILES N[C@H]1CCCC[C@H]1Nc1ncc(C(N)=O)c(Nc2ccc(Sc3ccccc3)cc2)n1
Show InChI InChI=1S/C23H26N6OS/c24-19-8-4-5-9-20(19)28-23-26-14-18(21(25)30)22(29-23)27-15-10-12-17(13-11-15)31-16-6-2-1-3-7-16/h1-3,6-7,10-14,19-20H,4-5,8-9,24H2,(H2,25,30)(H2,26,27,28,29)/t19-,20+/m0/s1
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Ziarco Pharma Ltd.

US Patent


Assay Description
The Promega ADP-Glo Kinase Assay is a luminescent ADP detection assay that provides a universal, homogeneous, high-throughput screening method to mea...

US Patent US9533989 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ31M7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM260809
PNG
(US9533989, 120)
Show SMILES Cc1nc(N[C@@H]2CCCC[C@@H]2N)nc(Nc2cccc(c2)-c2ccc(O)cc2)c1C(N)=O
Show InChI InChI=1S/C24H28N6O2/c1-14-21(22(26)32)23(30-24(27-14)29-20-8-3-2-7-19(20)25)28-17-6-4-5-16(13-17)15-9-11-18(31)12-10-15/h4-6,9-13,19-20,31H,2-3,7-8,25H2,1H3,(H2,26,32)(H2,27,28,29,30)/t19-,20+/m0/s1
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Ziarco Pharma Ltd.

US Patent


Assay Description
The Promega ADP-Glo Kinase Assay is a luminescent ADP detection assay that provides a universal, homogeneous, high-throughput screening method to mea...

US Patent US9533989 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ31M7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM260810
PNG
(US9533989, 121)
Show SMILES CC(C)C(=O)N1CCc2ccc(Nc3nc(N[C@@H]4CCCC[C@@H]4N)ncc3C(N)=O)cc2C1
Show InChI InChI=1S/C24H33N7O2/c1-14(2)23(33)31-10-9-15-7-8-17(11-16(15)13-31)28-22-18(21(26)32)12-27-24(30-22)29-20-6-4-3-5-19(20)25/h7-8,11-12,14,19-20H,3-6,9-10,13,25H2,1-2H3,(H2,26,32)(H2,27,28,29,30)/t19-,20+/m0/s1
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Ziarco Pharma Ltd.

US Patent


Assay Description
The Promega ADP-Glo Kinase Assay is a luminescent ADP detection assay that provides a universal, homogeneous, high-throughput screening method to mea...

US Patent US9533989 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ31M7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM260811
PNG
(US9533989, 122)
Show SMILES N[C@H]1CCCC[C@H]1Nc1ncc(C(N)=O)c(Nc2cccc3N(CCCc23)C(=O)C2CC2)n1
Show InChI InChI=1S/C24H31N7O2/c25-17-6-1-2-7-19(17)29-24-27-13-16(21(26)32)22(30-24)28-18-8-3-9-20-15(18)5-4-12-31(20)23(33)14-10-11-14/h3,8-9,13-14,17,19H,1-2,4-7,10-12,25H2,(H2,26,32)(H2,27,28,29,30)/t17-,19+/m0/s1
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n/an/a 284n/an/an/an/an/an/a



Ziarco Pharma Ltd.

US Patent


Assay Description
The Promega ADP-Glo Kinase Assay is a luminescent ADP detection assay that provides a universal, homogeneous, high-throughput screening method to mea...

US Patent US9533989 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ31M7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM260812
PNG
(US9533989, 123)
Show SMILES N[C@H]1CCCC[C@H]1Nc1ncc(C(N)=O)c(Nc2cccc3n(Cc4ccccc4Oc4ccccc4)ccc23)n1
Show InChI InChI=1S/C32H33N7O2/c33-25-12-5-6-13-27(25)37-32-35-19-24(30(34)40)31(38-32)36-26-14-8-15-28-23(26)17-18-39(28)20-21-9-4-7-16-29(21)41-22-10-2-1-3-11-22/h1-4,7-11,14-19,25,27H,5-6,12-13,20,33H2,(H2,34,40)(H2,35,36,37,38)/t25-,27+/m0/s1
PDB
MMDB

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KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 298n/an/an/an/an/an/a



Ziarco Pharma Ltd.

US Patent


Assay Description
The Promega ADP-Glo Kinase Assay is a luminescent ADP detection assay that provides a universal, homogeneous, high-throughput screening method to mea...

US Patent US9533989 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ31M7
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%