Found 772 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Apelin receptor
(Homo sapiens (Human)) | BDBM269515
((2R)-N-(4-(3,5-dimethyl-4-isoxazolyl)-5-(6-methoxy...)Show SMILES COc1cccc(n1)-c1nnc(NS(=O)(=O)[C@H](C)Cc2ncc(F)cn2)n1-c1c(C)noc1C |r,wD:16.17,(-8.76,-3.84,;-9.16,-2.35,;-8.07,-1.27,;-8.47,.22,;-7.38,1.31,;-5.89,.91,;-5.49,-.57,;-6.58,-1.66,;-4,-.97,;-3.53,-2.44,;-1.99,-2.44,;-1.51,-.97,;-.18,-.2,;1.15,-.97,;.38,-2.31,;1.92,-2.31,;2.49,-.2,;2.49,1.34,;3.82,-.97,;5.16,-.2,;6.49,-.97,;7.82,-.2,;7.82,1.34,;9.16,2.11,;6.49,2.11,;5.16,1.34,;-2.76,-.07,;-2.76,1.47,;-1.51,2.38,;-.18,1.61,;-1.99,3.84,;-3.53,3.84,;-4,2.38,;-5.34,1.61,)| Show InChI InChI=1S/C20H21FN8O4S/c1-11(8-16-22-9-14(21)10-23-16)34(30,31)28-20-26-25-19(15-6-5-7-17(24-15)32-4)29(20)18-12(2)27-33-13(18)3/h5-7,9-11H,8H2,1-4H3,(H,26,28)/t11-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 140 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US9845310 (2017)
BindingDB Entry DOI: 10.7270/Q28P62TV |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM269536
((1R,2S)-1-methoxy-N-(4-(2-methoxyphenyl)-5-(6-meth...)Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1-c1ccccc1OC)c1ncc(C)cn1 |r,wU:3.3,2.1,(5.9,-3.92,;4.57,-3.15,;4.57,-1.61,;3.23,-.84,;3.23,.7,;1.9,-1.61,;1.13,-2.94,;2.67,-2.94,;.57,-.84,;-.77,-1.61,;-1.24,-3.07,;-2.78,-3.07,;-3.26,-1.61,;-4.75,-1.21,;-5.15,.28,;-6.63,.68,;-7.72,-.41,;-7.32,-1.9,;-8.41,-2.99,;-9.9,-2.59,;-5.84,-2.3,;-2.01,-.7,;-2.01,.84,;-3.35,1.61,;-3.35,3.15,;-2.01,3.92,;-.68,3.15,;-.68,1.61,;.65,.84,;1.99,1.61,;5.9,-.84,;7.23,-1.61,;8.57,-.84,;8.57,.7,;9.9,1.47,;7.23,1.47,;5.9,.7,)| Show InChI InChI=1S/C24H27N7O5S/c1-15-13-25-22(26-14-15)21(36-5)16(2)37(32,33)30-24-29-28-23(17-9-8-12-20(27-17)35-4)31(24)18-10-6-7-11-19(18)34-3/h6-14,16,21H,1-5H3,(H,29,30)/t16-,21-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 4.20 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US9845310 (2017)
BindingDB Entry DOI: 10.7270/Q28P62TV |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM269546
((1R,2S)-1-methoxy-N-(5-(6-methoxy-2-pyridinyl)-4-(...)Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1-c1cccc(C)c1)c1ncc(C)cn1 |r| Show InChI InChI=1S/C24H27N7O4S/c1-15-8-6-9-18(12-15)31-23(19-10-7-11-20(27-19)34-4)28-29-24(31)30-36(32,33)17(3)21(35-5)22-25-13-16(2)14-26-22/h6-14,17,21H,1-5H3,(H,29,30)/t17-,21-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 6 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US9845310 (2017)
BindingDB Entry DOI: 10.7270/Q28P62TV |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM269552
((1R,2S)-N-(4-(3,5-dichlorophenyl)-5-(6-methoxy-2-p...)Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1-c1cc(Cl)cc(Cl)c1)c1ncc(C)cn1 |r| Show InChI InChI=1S/C23H23Cl2N7O4S/c1-13-11-26-21(27-12-13)20(36-4)14(2)37(33,34)31-23-30-29-22(18-6-5-7-19(28-18)35-3)32(23)17-9-15(24)8-16(25)10-17/h5-12,14,20H,1-4H3,(H,30,31)/t14-,20-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 60 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US9845310 (2017)
BindingDB Entry DOI: 10.7270/Q28P62TV |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM269571
((2S,3R)-N-(4-(2,6-dimethoxyphenyl)-5-(2-methyl-4-p...)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(C)cn2)nnc1-c1ccnc(C)c1 |r,wU:16.17,18.19,(-6.76,1.22,;-5.43,.45,;-4.09,1.22,;-4.09,2.76,;-2.76,3.53,;-1.42,2.76,;-1.42,1.22,;-.09,.45,;1.24,1.22,;-2.76,.45,;-2.76,-1.09,;-1.51,-1.99,;-.18,-1.22,;1.15,-1.99,;.38,-3.33,;1.92,-3.33,;2.49,-1.22,;2.49,.32,;3.82,-1.99,;3.82,-3.53,;5.16,-1.22,;6.49,-1.99,;7.82,-1.22,;7.82,.32,;9.16,1.09,;6.49,1.09,;5.16,.32,;-1.99,-3.46,;-3.53,-3.46,;-4,-1.99,;-5.49,-1.59,;-5.89,-.11,;-7.38,.29,;-8.47,-.8,;-8.07,-2.28,;-9.16,-3.37,;-6.58,-2.68,)| Show InChI InChI=1S/C25H29N7O4S/c1-15-13-27-23(28-14-15)17(3)18(4)37(33,34)31-25-30-29-24(19-10-11-26-16(2)12-19)32(25)22-20(35-5)8-7-9-21(22)36-6/h7-14,17-18H,1-6H3,(H,30,31)/t17-,18-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 5.20 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US9845310 (2017)
BindingDB Entry DOI: 10.7270/Q28P62TV |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM269578
((1R,2R)-N-(4-(2,6-dimethoxyphenyl)-5-(5-methyl-3-p...)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@H](C)[C@H](OC(C)C)c2ncc(C)cn2)nnc1-c1cncc(C)c1 |r,wU:18.19,wD:16.17,(-6.76,2.38,;-5.43,1.61,;-4.09,2.38,;-4.09,3.92,;-2.76,4.69,;-1.42,3.92,;-1.42,2.38,;-.09,1.61,;1.24,2.38,;-2.76,1.61,;-2.76,.07,;-1.51,-.84,;-.18,-.07,;1.15,-.84,;.38,-2.17,;1.92,-2.17,;2.49,-.07,;2.49,1.47,;3.82,-.84,;3.82,-2.38,;5.16,-3.15,;6.49,-2.38,;5.16,-4.69,;5.16,-.07,;6.49,-.84,;7.82,-.07,;7.82,1.47,;9.16,2.24,;6.49,2.24,;5.16,1.47,;-1.99,-2.3,;-3.53,-2.3,;-4,-.84,;-5.49,-.44,;-5.89,1.05,;-7.38,1.45,;-8.47,.36,;-8.07,-1.13,;-9.16,-2.22,;-6.58,-1.53,)| Show InChI InChI=1S/C27H33N7O5S/c1-16(2)39-24(25-29-13-18(4)14-30-25)19(5)40(35,36)33-27-32-31-26(20-11-17(3)12-28-15-20)34(27)23-21(37-6)9-8-10-22(23)38-7/h8-16,19,24H,1-7H3,(H,32,33)/t19-,24+/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 140 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US9845310 (2017)
BindingDB Entry DOI: 10.7270/Q28P62TV |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM269580
((1S,2R)-N-(4-(2,6-dimethoxyphenyl)-5-(5-methyl-3-p...)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@H](C)[C@@H](OC(C)C)c2ncc(C)cn2)nnc1-c1cncc(C)c1 |r,wD:16.17,18.19,(-6.76,2.38,;-5.43,1.61,;-4.09,2.38,;-4.09,3.92,;-2.76,4.69,;-1.42,3.92,;-1.42,2.38,;-.09,1.61,;1.24,2.38,;-2.76,1.61,;-2.76,.07,;-1.51,-.84,;-.18,-.07,;1.15,-.84,;.38,-2.17,;1.92,-2.17,;2.49,-.07,;2.49,1.47,;3.82,-.84,;3.82,-2.38,;5.16,-3.15,;6.49,-2.38,;5.16,-4.69,;5.16,-.07,;6.49,-.84,;7.82,-.07,;7.82,1.47,;9.16,2.24,;6.49,2.24,;5.16,1.47,;-1.99,-2.3,;-3.53,-2.3,;-4,-.84,;-5.49,-.44,;-5.89,1.05,;-7.38,1.45,;-8.47,.36,;-8.07,-1.13,;-9.16,-2.22,;-6.58,-1.53,)| Show InChI InChI=1S/C27H33N7O5S/c1-16(2)39-24(25-29-13-18(4)14-30-25)19(5)40(35,36)33-27-32-31-26(20-11-17(3)12-28-15-20)34(27)23-21(37-6)9-8-10-22(23)38-7/h8-16,19,24H,1-7H3,(H,32,33)/t19-,24-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 150 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US9845310 (2017)
BindingDB Entry DOI: 10.7270/Q28P62TV |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM269583
((1S,2R)-N-(4-(2,6-dimethoxyphenyl)-5-(6-methoxy-2-...)Show SMILES COc1cccc(n1)-c1nnc(NS(=O)(=O)[C@H](C)[C@@H](OC(C)C)c2ncc(C)cn2)n1-c1c(OC)cccc1OC |r,wD:16.17,18.19,(-10.64,-1.82,;-9.16,-2.22,;-8.07,-1.13,;-8.47,.36,;-7.38,1.45,;-5.89,1.05,;-5.49,-.44,;-6.58,-1.53,;-4,-.84,;-3.53,-2.3,;-1.99,-2.3,;-1.51,-.84,;-.18,-.07,;1.15,-.84,;.38,-2.17,;1.92,-2.17,;2.49,-.07,;2.49,1.47,;3.82,-.84,;3.82,-2.38,;5.16,-3.15,;6.49,-2.38,;5.16,-4.69,;5.16,-.07,;6.49,-.84,;7.82,-.07,;7.82,1.47,;9.16,2.24,;6.49,2.24,;5.16,1.47,;-2.76,.07,;-2.76,1.61,;-4.09,2.38,;-5.43,1.61,;-6.76,2.38,;-4.09,3.92,;-2.76,4.69,;-1.42,3.92,;-1.42,2.38,;-.09,1.61,;1.24,2.38,)| Show InChI InChI=1S/C27H33N7O6S/c1-16(2)40-24(25-28-14-17(3)15-29-25)18(4)41(35,36)33-27-32-31-26(19-10-8-13-22(30-19)39-7)34(27)23-20(37-5)11-9-12-21(23)38-6/h8-16,18,24H,1-7H3,(H,32,33)/t18-,24-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 2 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US9845310 (2017)
BindingDB Entry DOI: 10.7270/Q28P62TV |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM269590
((1R,2S)-N-(4-(2,6-dimethoxyphenyl)-5-(2-methyl-4-p...)Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2ccnc(C)c2)n1-c1c(OC)cccc1OC)c1ncc(C)cn1 |r,wU:3.3,2.1,(5.16,-3.92,;3.82,-3.15,;3.82,-1.61,;2.49,-.84,;2.49,.7,;1.15,-1.61,;.38,-2.94,;1.92,-2.94,;-.18,-.84,;-1.51,-1.61,;-1.99,-3.07,;-3.53,-3.07,;-4,-1.61,;-5.49,-1.21,;-5.89,.28,;-7.38,.68,;-8.47,-.41,;-8.07,-1.9,;-9.16,-2.99,;-6.58,-2.3,;-2.76,-.7,;-2.76,.84,;-4.09,1.61,;-5.43,.84,;-6.76,1.61,;-4.09,3.15,;-2.76,3.92,;-1.42,3.15,;-1.42,1.61,;-.09,.84,;1.24,1.61,;5.16,-.84,;6.49,-1.61,;7.82,-.84,;7.82,.7,;9.16,1.47,;6.49,1.47,;5.16,.7,)| Show InChI InChI=1S/C25H29N7O5S/c1-15-13-27-23(28-14-15)22(37-6)17(3)38(33,34)31-25-30-29-24(18-10-11-26-16(2)12-18)32(25)21-19(35-4)8-7-9-20(21)36-5/h7-14,17,22H,1-6H3,(H,30,31)/t17-,22-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 2.40 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US9845310 (2017)
BindingDB Entry DOI: 10.7270/Q28P62TV |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM269592
((1S,2R)-N-(4-(2,6-dimethoxyphenyl)-5-(6-methoxy-2-...)Show SMILES CCO[C@H]([C@@H](C)S(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1-c1c(OC)cccc1OC)c1ncc(C)cn1 |r,wD:4.4,3.2,(4.86,-4.69,;4.86,-3.15,;3.53,-2.38,;3.53,-.84,;2.2,-.07,;2.2,1.47,;.86,-.84,;.09,-2.17,;1.63,-2.17,;-.47,-.07,;-1.81,-.84,;-2.28,-2.3,;-3.82,-2.3,;-4.3,-.84,;-5.78,-.44,;-6.55,.89,;-8.09,.89,;-8.86,-.44,;-8.09,-1.77,;-8.86,-3.11,;-10.4,-3.11,;-6.55,-1.77,;-3.05,.07,;-3.05,1.61,;-1.59,2.32,;-.25,1.55,;1.08,2.33,;-1.72,3.92,;-3.05,4.69,;-4.38,3.92,;-4.38,2.38,;-5.72,1.61,;-7.05,2.38,;4.86,-.07,;6.2,-.84,;7.53,-.07,;7.53,1.47,;8.86,2.24,;6.2,2.24,;4.86,1.47,)| Show InChI InChI=1S/C26H31N7O6S/c1-7-39-23(24-27-14-16(2)15-28-24)17(3)40(34,35)32-26-31-30-25(18-10-8-13-21(29-18)38-6)33(26)22-19(36-4)11-9-12-20(22)37-5/h8-15,17,23H,7H2,1-6H3,(H,31,32)/t17-,23-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 15 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US9845310 (2017)
BindingDB Entry DOI: 10.7270/Q28P62TV |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM269601
((2R)-N-(4-(2,6-dimethoxyphenyl)-5-(6-methoxy-2-pyr...)Show SMILES COc1cccc(n1)-c1nnc(NS(=O)(=O)[C@@H](C)Cc2ncc(F)cn2)n1-c1c(OC)cccc1OC |r,wU:16.17,(-8.12,-4.76,;-8.89,-3.43,;-8.12,-2.1,;-8.89,-.76,;-8.12,.57,;-6.58,.57,;-5.81,-.76,;-6.58,-2.1,;-4.27,-.76,;-3.79,-2.23,;-2.25,-2.23,;-1.78,-.76,;-.45,.01,;.89,-.76,;.12,-2.1,;1.66,-2.1,;2.22,.01,;2.22,1.55,;3.56,-.76,;4.89,.01,;6.22,-.76,;7.56,.01,;7.56,1.55,;8.89,2.32,;6.22,2.32,;4.89,1.55,;-3.02,.14,;-3.02,1.68,;-4.36,2.45,;-5.69,1.68,;-7.03,2.45,;-4.36,3.99,;-3.02,4.76,;-1.69,3.99,;-1.69,2.45,;-.36,1.68,;.98,2.45,)| Show InChI InChI=1S/C23H24FN7O5S/c1-14(11-19-25-12-15(24)13-26-19)37(32,33)30-23-29-28-22(16-7-5-10-20(27-16)36-4)31(23)21-17(34-2)8-6-9-18(21)35-3/h5-10,12-14H,11H2,1-4H3,(H,29,30)/t14-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 0.25 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US9845310 (2017)
BindingDB Entry DOI: 10.7270/Q28P62TV |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM269607
((1S,2R)-N-(4-(2,6-dimethoxyphenyl)-5-(6-methyl-2-p...)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](O)c2ncc(F)cn2)nnc1-c1cccc(C)n1 |r,wU:16.17,18.19,(1.27,2.13,;.18,1.04,;-1.31,1.44,;-1.71,2.92,;-3.19,3.32,;-4.28,2.23,;-3.88,.75,;-4.97,-.34,;-6.46,.06,;-2.4,.35,;-2,-1.14,;-.53,-1.62,;.8,-.85,;2.13,-1.62,;1.36,-2.95,;3.47,-2.39,;2.9,-.28,;2.13,1.05,;4.44,-.28,;5.21,-1.62,;5.21,1.05,;6.75,1.05,;7.52,2.39,;6.75,3.72,;7.52,5.05,;5.21,3.72,;4.44,2.39,;-.53,-3.16,;-2,-3.63,;-2.9,-2.39,;-4.44,-2.39,;-5.21,-1.05,;-6.75,-1.05,;-7.52,-2.39,;-6.75,-3.72,;-7.52,-5.05,;-5.21,-3.72,)| Show InChI InChI=1S/C23H24FN7O5S/c1-13-7-5-8-16(27-13)22-28-29-23(31(22)19-17(35-3)9-6-10-18(19)36-4)30-37(33,34)14(2)20(32)21-25-11-15(24)12-26-21/h5-12,14,20,32H,1-4H3,(H,29,30)/t14-,20-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 20 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US9845310 (2017)
BindingDB Entry DOI: 10.7270/Q28P62TV |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM269623
((2S)-N-(4-(2,6-dimethoxyphenyl)-5-(5-(trifluoromet...)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)Cc2ncc(F)cn2)nnc1-c1cncc(c1)C(F)(F)F |r,wU:16.17,(1.08,2.33,;-.25,1.55,;-1.59,2.32,;-1.72,3.92,;-3.05,4.69,;-4.38,3.92,;-4.38,2.38,;-5.72,1.61,;-7.05,2.38,;-3.05,1.61,;-3.05,.07,;-1.81,-.84,;-.47,-.07,;.86,-.84,;.09,-2.17,;1.63,-2.17,;2.2,-.07,;2.2,1.47,;3.53,-.84,;4.86,-.07,;6.2,-.84,;7.53,-.07,;7.53,1.47,;8.86,2.24,;6.2,2.24,;4.86,1.47,;-2.28,-2.3,;-3.82,-2.3,;-4.3,-.84,;-5.78,-.44,;-6.55,.89,;-8.09,.89,;-8.86,-.44,;-8.09,-1.77,;-6.55,-1.77,;-8.86,-3.11,;-10.4,-3.11,;-8.09,-4.44,;-7.32,-3.11,)| Show InChI InChI=1S/C23H21F4N7O4S/c1-13(7-19-29-11-16(24)12-30-19)39(35,36)33-22-32-31-21(14-8-15(10-28-9-14)23(25,26)27)34(22)20-17(37-2)5-4-6-18(20)38-3/h4-6,8-13H,7H2,1-3H3,(H,32,33)/t13-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 36 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US9845310 (2017)
BindingDB Entry DOI: 10.7270/Q28P62TV |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM269628
((2S)-N-(4-(2,6-dimethoxyphenyl)-5-(6-ethoxy-2-pyri...)Show SMILES CCOc1cccc(n1)-c1nnc(NS(=O)(=O)[C@@H](C)Cc2ncc(F)cn2)n1-c1c(OC)cccc1OC |r,wU:17.18,(-11.2,3.24,;-10.43,1.91,;-8.89,1.91,;-8.12,.57,;-8.89,-.76,;-8.12,-2.1,;-6.58,-2.1,;-5.81,-.76,;-6.58,.57,;-4.27,-.76,;-3.79,-2.23,;-2.25,-2.23,;-1.78,-.76,;-.45,.01,;.89,-.76,;.12,-2.1,;1.66,-2.1,;2.22,.01,;2.22,1.55,;3.56,-.76,;4.89,.01,;6.22,-.76,;7.56,.01,;7.56,1.55,;8.89,2.32,;6.22,2.32,;4.89,1.55,;-3.02,.14,;-3.02,1.68,;-1.69,2.45,;-.36,1.68,;.98,2.45,;-1.69,3.99,;-3.02,4.76,;-4.36,3.99,;-4.36,2.45,;-5.69,1.68,;-7.03,2.45,)| Show InChI InChI=1S/C24H26FN7O5S/c1-5-37-21-11-6-8-17(28-21)23-29-30-24(32(23)22-18(35-3)9-7-10-19(22)36-4)31-38(33,34)15(2)12-20-26-13-16(25)14-27-20/h6-11,13-15H,5,12H2,1-4H3,(H,30,31)/t15-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 0.120 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US9845310 (2017)
BindingDB Entry DOI: 10.7270/Q28P62TV |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM269636
((2S)-N-(5-(6-cyano-2-pyridinyl)-4-(2,6-dimethoxyph...)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)Cc2ncc(F)cn2)nnc1-c1cccc(n1)C#N |r,wU:16.17,(1.36,2.45,;.03,1.68,;-1.31,2.45,;-1.31,3.99,;-2.64,4.76,;-3.97,3.99,;-3.97,2.45,;-5.31,1.68,;-6.64,2.45,;-2.64,1.68,;-2.64,.14,;-1.39,-.76,;-.06,.01,;1.27,-.76,;.5,-2.1,;2.04,-2.1,;2.61,.01,;2.61,1.55,;3.94,-.76,;5.27,.01,;6.61,-.76,;7.94,.01,;7.94,1.55,;9.28,2.32,;6.61,2.32,;5.27,1.55,;-1.87,-2.23,;-3.41,-2.23,;-3.89,-.76,;-5.43,-.76,;-6.2,.57,;-7.74,.57,;-8.51,-.76,;-7.75,-2.19,;-6.2,-2.1,;-8.5,-3.54,;-9.25,-4.88,)| Show InChI InChI=1S/C23H21FN8O4S/c1-14(10-20-26-12-15(24)13-27-20)37(33,34)31-23-30-29-22(17-7-4-6-16(11-25)28-17)32(23)21-18(35-2)8-5-9-19(21)36-3/h4-9,12-14H,10H2,1-3H3,(H,30,31)/t14-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 74 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US9845310 (2017)
BindingDB Entry DOI: 10.7270/Q28P62TV |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM269636
((2S)-N-(5-(6-cyano-2-pyridinyl)-4-(2,6-dimethoxyph...)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)Cc2ncc(F)cn2)nnc1-c1cccc(n1)C#N |r,wU:16.17,(1.36,2.45,;.03,1.68,;-1.31,2.45,;-1.31,3.99,;-2.64,4.76,;-3.97,3.99,;-3.97,2.45,;-5.31,1.68,;-6.64,2.45,;-2.64,1.68,;-2.64,.14,;-1.39,-.76,;-.06,.01,;1.27,-.76,;.5,-2.1,;2.04,-2.1,;2.61,.01,;2.61,1.55,;3.94,-.76,;5.27,.01,;6.61,-.76,;7.94,.01,;7.94,1.55,;9.28,2.32,;6.61,2.32,;5.27,1.55,;-1.87,-2.23,;-3.41,-2.23,;-3.89,-.76,;-5.43,-.76,;-6.2,.57,;-7.74,.57,;-8.51,-.76,;-7.75,-2.19,;-6.2,-2.1,;-8.5,-3.54,;-9.25,-4.88,)| Show InChI InChI=1S/C23H21FN8O4S/c1-14(10-20-26-12-15(24)13-27-20)37(33,34)31-23-30-29-22(17-7-4-6-16(11-25)28-17)32(23)21-18(35-2)8-5-9-19(21)36-3/h4-9,12-14H,10H2,1-3H3,(H,30,31)/t14-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 39 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US9845310 (2017)
BindingDB Entry DOI: 10.7270/Q28P62TV |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM269655
((2S)-N-(5-(6-(difluoromethoxy)-2-pyridinyl)-4-(2,6...)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)Cc2ncc(F)cn2)nnc1-c1cccc(OC(F)F)n1 |r,wU:16.17,(.98,3.12,;-.36,2.35,;-1.69,3.12,;-1.69,4.66,;-3.02,5.43,;-4.36,4.66,;-4.36,3.12,;-5.69,2.35,;-7.03,3.12,;-3.02,2.35,;-3.02,.81,;-1.78,-.1,;-.45,.67,;.89,-.1,;.12,-1.43,;1.66,-1.43,;2.22,.67,;2.22,2.21,;3.56,-.1,;4.89,.67,;6.22,-.1,;7.56,.67,;7.56,2.21,;8.89,2.98,;6.22,2.98,;4.89,2.21,;-2.25,-1.56,;-3.79,-1.56,;-4.27,-.1,;-5.81,-.1,;-6.58,1.24,;-8.12,1.24,;-8.89,-.1,;-8.12,-1.43,;-8.89,-2.76,;-8.12,-4.1,;-8.89,-5.43,;-6.58,-4.1,;-6.58,-1.43,)| Show InChI InChI=1S/C23H22F3N7O5S/c1-13(10-18-27-11-14(24)12-28-18)39(34,35)32-23-31-30-21(15-6-4-9-19(29-15)38-22(25)26)33(23)20-16(36-2)7-5-8-17(20)37-3/h4-9,11-13,22H,10H2,1-3H3,(H,31,32)/t13-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 1.80 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US9845310 (2017)
BindingDB Entry DOI: 10.7270/Q28P62TV |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM269663
((2S,3R)-N-(4-(2,6-dimethoxyphenyl)-5-(6-methoxy-4-...)Show SMILES COc1cc(C)cc(n1)-c1nnc(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(F)cn2)n1-c1c(OC)cccc1OC |r,wU:17.18,19.20,(-8.12,-4.76,;-8.89,-3.43,;-8.12,-2.1,;-8.89,-.76,;-8.12,.57,;-8.89,1.91,;-6.58,.57,;-5.81,-.76,;-6.58,-2.1,;-4.27,-.76,;-3.79,-2.23,;-2.25,-2.23,;-1.78,-.76,;-.45,.01,;.89,-.76,;.12,-2.1,;1.66,-2.1,;2.22,.01,;2.22,1.55,;3.56,-.76,;3.56,-2.3,;4.89,.01,;6.22,-.76,;7.56,.01,;7.56,1.55,;8.89,2.32,;6.22,2.32,;4.89,1.55,;-3.02,.14,;-3.02,1.68,;-1.69,2.45,;-.36,1.68,;.98,2.45,;-1.69,3.99,;-3.02,4.76,;-4.36,3.99,;-4.36,2.45,;-5.69,1.68,;-7.03,2.45,)| Show InChI InChI=1S/C25H28FN7O5S/c1-14-10-18(29-21(11-14)38-6)24-30-31-25(33(24)22-19(36-4)8-7-9-20(22)37-5)32-39(34,35)16(3)15(2)23-27-12-17(26)13-28-23/h7-13,15-16H,1-6H3,(H,31,32)/t15-,16-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 0.120 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US9845310 (2017)
BindingDB Entry DOI: 10.7270/Q28P62TV |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM269666
((2S,3R)-N-(4-(2,6-dimethoxyphenyl)-5-(6-ethoxy-2-p...)Show SMILES CCOc1cccc(n1)-c1nnc(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(C)cn2)n1-c1c(OC)cccc1OC |r,wU:17.18,19.20,(-8.89,-5.43,;-8.12,-4.1,;-8.89,-2.76,;-8.12,-1.43,;-8.89,-.1,;-8.12,1.24,;-6.58,1.24,;-5.81,-.1,;-6.58,-1.43,;-4.27,-.1,;-3.79,-1.56,;-2.25,-1.56,;-1.78,-.1,;-.45,.67,;.89,-.1,;.12,-1.43,;1.66,-1.43,;2.22,.67,;2.22,2.21,;3.56,-.1,;3.56,-1.64,;4.89,.67,;6.22,-.1,;7.56,.67,;7.56,2.21,;8.89,2.98,;6.22,2.98,;4.89,2.21,;-3.02,.81,;-3.02,2.35,;-1.69,3.12,;-.36,2.35,;.98,3.12,;-1.69,4.66,;-3.02,5.43,;-4.36,4.66,;-4.36,3.12,;-5.69,2.35,;-7.03,3.12,)| Show InChI InChI=1S/C26H31N7O5S/c1-7-38-22-13-8-10-19(29-22)25-30-31-26(33(25)23-20(36-5)11-9-12-21(23)37-6)32-39(34,35)18(4)17(3)24-27-14-16(2)15-28-24/h8-15,17-18H,7H2,1-6H3,(H,31,32)/t17-,18-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 0.0680 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US9845310 (2017)
BindingDB Entry DOI: 10.7270/Q28P62TV |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM269682
((1R,2S)-N-(4-(2,6-dimethoxyphenyl)-5-(6-(dimethyla...)Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccc(n2)N(C)C)n1-c1c(OC)cccc1OC)c1ncc(C)cn1 |r,wU:3.3,2.1,(6.85,-3.21,;5.36,-2.82,;4.96,-1.33,;3.48,-.93,;3.08,.56,;2.39,-2.02,;1.3,-3.11,;3.48,-3.11,;1.3,-.93,;-.19,-1.33,;-.66,-2.79,;-2.2,-2.79,;-2.68,-1.33,;-4.17,-.93,;-4.57,.56,;-6.05,.96,;-7.14,-.13,;-6.74,-1.62,;-5.26,-2.02,;-7.83,-2.71,;-9.32,-2.31,;-7.43,-4.2,;-1.43,-.42,;-1.43,1.12,;-.1,1.89,;1.23,1.12,;2.57,1.89,;-.1,3.43,;-1.43,4.2,;-2.77,3.43,;-2.77,1.89,;-4.1,1.12,;-5.44,1.89,;6.05,-.24,;7.54,-.64,;8.63,.45,;8.23,1.94,;9.32,3.03,;6.74,2.34,;5.66,1.25,)| Show InChI InChI=1S/C26H32N8O5S/c1-16-14-27-24(28-15-16)23(39-7)17(2)40(35,36)32-26-31-30-25(18-10-8-13-21(29-18)33(3)4)34(26)22-19(37-5)11-9-12-20(22)38-6/h8-15,17,23H,1-7H3,(H,31,32)/t17-,23-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 0.210 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US9845310 (2017)
BindingDB Entry DOI: 10.7270/Q28P62TV |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM269691
((2S)—N-(4-(2,6-dimethoxyphenyl)-5-(3-pyridiny...)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@H](C)Cc2ncc(F)cn2)nnc1-c1cccnc1 |r,wD:16.17,(-6.48,-6.09,;-5.15,-6.86,;-3.81,-6.09,;-3.81,-4.55,;-2.48,-3.78,;-1.15,-4.55,;-1.15,-6.09,;.19,-6.86,;1.52,-6.09,;-2.48,-6.86,;-2.48,-8.4,;-1.23,-9.3,;.1,-8.53,;1.43,-9.3,;2.77,-10.07,;.1,-10.07,;2.77,-8.53,;2.77,-6.99,;4.1,-9.3,;5.44,-8.53,;6.77,-9.3,;8.1,-8.53,;8.1,-6.99,;9.44,-6.22,;6.77,-6.22,;5.44,-6.99,;-1.71,-10.77,;-3.25,-10.77,;-3.72,-9.3,;-5.26,-9.3,;-6.03,-7.97,;-7.57,-7.97,;-8.34,-9.3,;-7.57,-10.64,;-6.03,-10.64,)| Show InChI InChI=1S/C22H22FN7O4S/c1-14(10-19-25-12-16(23)13-26-19)35(31,32)29-22-28-27-21(15-6-5-9-24-11-15)30(22)20-17(33-2)7-4-8-18(20)34-3/h4-9,11-14H,10H2,1-3H3,(H,28,29)/t14-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 25 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US9845310 (2017)
BindingDB Entry DOI: 10.7270/Q28P62TV |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM363104
(N-(4-(2,6-dimethoxyphenyl)-5-(3-pyridinyl)-4H-1,2,...)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)C(C)Cc2ncc(F)cn2)nnc1-c1cccnc1 |(-7.16,-3.61,;-5.82,-4.38,;-4.49,-3.61,;-4.49,-2.07,;-3.16,-1.3,;-1.82,-2.07,;-1.82,-3.61,;-.49,-4.38,;.85,-3.61,;-3.16,-4.38,;-3.16,-5.92,;-1.91,-6.82,;-.58,-6.05,;.76,-6.82,;-.01,-8.16,;1.53,-8.16,;2.09,-6.05,;2.09,-4.51,;3.43,-6.82,;4.76,-6.05,;6.09,-6.82,;7.43,-6.05,;7.43,-4.51,;8.76,-3.74,;6.09,-3.74,;4.76,-4.51,;-2.39,-8.29,;-3.93,-8.29,;-4.4,-6.82,;-5.94,-6.82,;-6.71,-5.49,;-8.25,-5.49,;-9.02,-6.82,;-8.25,-8.16,;-6.71,-8.16,)| Show InChI InChI=1S/C22H22FN7O4S/c1-14(10-19-25-12-16(23)13-26-19)35(31,32)29-22-28-27-21(15-6-5-9-24-11-15)30(22)20-17(33-2)7-4-8-18(20)34-3/h4-9,11-14H,10H2,1-3H3,(H,28,29) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 6.40 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US9845310 (2017)
BindingDB Entry DOI: 10.7270/Q28P62TV |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM269694
((2S)-N-(4-(2,6-dimethoxyphenyl)-5-(5-methyl-3-pyri...)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)Cc2ncc(F)cn2)nnc1-c1cncc(C)c1 |r,wU:16.17,(-7.03,5.9,;-5.69,5.13,;-4.36,5.9,;-4.36,7.44,;-3.02,8.21,;-1.69,7.44,;-1.69,5.9,;-.36,5.13,;.98,5.9,;-3.02,5.13,;-3.02,3.59,;-1.78,2.68,;-.45,3.45,;.89,2.68,;.12,1.35,;1.66,1.35,;2.22,3.45,;2.22,4.99,;3.56,2.68,;4.89,3.45,;6.22,2.68,;7.56,3.45,;7.56,4.99,;8.89,5.76,;6.22,5.76,;4.89,4.99,;-2.25,1.22,;-3.79,1.22,;-4.27,2.68,;-5.81,2.68,;-6.58,1.35,;-8.12,1.35,;-8.89,2.68,;-8.12,4.02,;-8.89,5.35,;-6.58,4.02,)| Show InChI InChI=1S/C23H24FN7O4S/c1-14-8-16(11-25-10-14)22-28-29-23(31(22)21-18(34-3)6-5-7-19(21)35-4)30-36(32,33)15(2)9-20-26-12-17(24)13-27-20/h5-8,10-13,15H,9H2,1-4H3,(H,29,30)/t15-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 4.90 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US9845310 (2017)
BindingDB Entry DOI: 10.7270/Q28P62TV |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM269713
(6-(4-(2,6-dimethoxyphenyl)-5-((((1S)-2-(5-fluoro-2...)Show SMILES CCNC(=O)c1cccc(n1)-c1nnc(NS(=O)(=O)[C@@H](C)Cc2ncc(F)cn2)n1-c1c(OC)cccc1OC |r,wU:19.20,(-5.04,2.44,;-5.81,1.1,;-7.35,1.1,;-8.12,2.44,;-9.66,2.44,;-7.35,3.77,;-8.12,5.1,;-7.35,6.44,;-5.81,6.44,;-5.04,5.1,;-5.81,3.77,;-3.5,5.1,;-3.02,3.64,;-1.48,3.64,;-1.01,5.1,;.32,5.87,;1.66,5.1,;.89,3.77,;2.43,3.77,;2.99,5.87,;2.99,7.41,;4.33,5.1,;5.66,5.87,;6.99,5.1,;8.33,5.87,;8.33,7.41,;9.66,8.18,;6.99,8.18,;5.66,7.41,;-2.25,6.01,;-2.25,7.55,;-3.59,8.32,;-4.92,7.55,;-6.26,8.32,;-3.59,9.86,;-2.25,10.63,;-.92,9.86,;-.92,8.32,;.41,7.55,;1.75,8.32,)| Show InChI InChI=1S/C25H27FN8O5S/c1-5-27-24(35)18-9-6-8-17(30-18)23-31-32-25(34(23)22-19(38-3)10-7-11-20(22)39-4)33-40(36,37)15(2)12-21-28-13-16(26)14-29-21/h6-11,13-15H,5,12H2,1-4H3,(H,27,35)(H,32,33)/t15-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 6.30 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US9845310 (2017)
BindingDB Entry DOI: 10.7270/Q28P62TV |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM269716
(6-(4-(2,6-dimethoxyphenyl)-5-((((1S)-2-(5-fluoro-2...)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)Cc2ncc(F)cn2)nnc1-c1cccc(n1)C(=O)N(C)C |r,wU:16.17,(-6.26,9.32,;-4.92,8.55,;-3.59,9.32,;-3.59,10.86,;-2.25,11.63,;-.92,10.86,;-.92,9.32,;.41,8.55,;1.75,9.32,;-2.25,8.55,;-2.25,7.01,;-1.01,6.1,;.32,6.87,;1.66,6.1,;.89,4.77,;2.43,4.77,;2.99,6.87,;2.99,8.41,;4.33,6.1,;5.66,6.87,;6.99,6.1,;8.33,6.87,;8.33,8.41,;9.66,9.18,;6.99,9.18,;5.66,8.41,;-1.48,4.64,;-3.02,4.64,;-3.5,6.1,;-5.04,6.1,;-5.81,7.44,;-7.35,7.44,;-8.12,6.1,;-7.35,4.77,;-5.81,4.77,;-8.12,3.44,;-9.66,3.44,;-7.35,2.1,;-5.81,2.1,;-8.12,.77,)| Show InChI InChI=1S/C25H27FN8O5S/c1-15(12-21-27-13-16(26)14-28-21)40(36,37)32-25-31-30-23(17-8-6-9-18(29-17)24(35)33(2)3)34(25)22-19(38-4)10-7-11-20(22)39-5/h6-11,13-15H,12H2,1-5H3,(H,31,32)/t15-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 45 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US9845310 (2017)
BindingDB Entry DOI: 10.7270/Q28P62TV |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM269720
((2S,3R)—N-(4-(2,6-dimethoxyphenyl)-5-(5-methy...)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@@H](C)c2ncc(F)cn2)nnc1-c1cncc(C)c1 |r,wU:16.17,wD:18.19,(.85,-12.76,;-.49,-13.53,;-1.82,-12.76,;-1.82,-11.22,;-3.16,-10.45,;-4.49,-11.22,;-4.49,-12.76,;-5.82,-13.53,;-7.16,-12.76,;-3.16,-13.53,;-3.16,-15.07,;-1.91,-15.98,;-.58,-15.21,;.76,-15.98,;-.01,-17.31,;1.53,-17.31,;2.09,-15.21,;2.09,-13.67,;3.43,-15.98,;3.43,-17.52,;4.76,-15.21,;6.09,-15.98,;7.43,-15.21,;7.43,-13.67,;8.76,-12.9,;6.09,-12.9,;4.76,-13.67,;-2.39,-17.44,;-3.93,-17.44,;-4.4,-15.98,;-5.94,-15.98,;-6.71,-17.31,;-8.25,-17.31,;-9.02,-15.98,;-8.25,-14.65,;-9.02,-13.31,;-6.71,-14.65,)| Show InChI InChI=1S/C24H26FN7O4S/c1-14-9-17(11-26-10-14)23-29-30-24(32(23)21-19(35-4)7-6-8-20(21)36-5)31-37(33,34)16(3)15(2)22-27-12-18(25)13-28-22/h6-13,15-16H,1-5H3,(H,30,31)/t15-,16+/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 0.280 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US9845310 (2017)
BindingDB Entry DOI: 10.7270/Q28P62TV |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM359952
((1S,2R)-N-(4-(2,6-dimethoxyphenyl)-5-(3-pyridinyl)...)Show SMILES CO[C@H]([C@@H](C)S(=O)(=O)Nc1nnc(-c2cccnc2)n1-c1c(OC)cccc1OC)c1ncc(F)cn1 |r,wD:3.3,2.1,(-6.59,.22,;-5.13,-.25,;-4.81,-1.76,;-3.34,-2.23,;-3.02,-3.74,;-2.2,-1.2,;-3.23,-.06,;-1.17,-2.35,;-1.05,-.17,;.41,-.65,;.89,-2.11,;2.43,-2.11,;2.9,-.65,;4.37,-.17,;5.51,-1.2,;6.98,-.73,;7.3,.78,;6.15,1.81,;4.69,1.33,;1.66,.26,;1.66,1.8,;2.99,2.57,;4.32,1.8,;5.66,2.57,;2.99,4.11,;1.66,4.88,;.32,4.11,;.32,2.57,;-1.01,1.8,;-2.19,2.79,;-5.95,-2.79,;-5.63,-4.29,;-6.78,-5.32,;-8.24,-4.85,;-9.39,-5.88,;-8.56,-3.34,;-7.42,-2.31,)| Show InChI InChI=1S/C23H24FN7O5S/c1-14(20(36-4)21-26-12-16(24)13-27-21)37(32,33)30-23-29-28-22(15-7-6-10-25-11-15)31(23)19-17(34-2)8-5-9-18(19)35-3/h5-14,20H,1-4H3,(H,29,30)/t14-,20-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 150 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US9845310 (2017)
BindingDB Entry DOI: 10.7270/Q28P62TV |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM269735
((1R,2S)-N-(4-(2,6-dimethoxyphenyl)-5-(5-methyl-3-p...)Show SMILES CCO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cncc(C)c2)n1-c1c(OC)cccc1OC)c1ncc(C)cn1 |r,wU:4.4,3.2,(4.79,-4.69,;4.79,-3.15,;3.45,-2.38,;3.45,-.84,;2.12,-.07,;2.12,1.47,;.79,-.84,;.02,-2.17,;1.56,-2.17,;-.55,-.07,;-1.88,-.84,;-2.36,-2.3,;-3.9,-2.3,;-4.37,-.84,;-5.71,-.07,;-6.48,-1.4,;-8.02,-1.4,;-8.79,-.07,;-8.02,1.27,;-8.79,2.6,;-6.48,1.27,;-3.13,.07,;-3.13,1.61,;-1.72,2.29,;-.4,1.51,;.95,2.26,;-1.79,3.92,;-3.13,4.69,;-4.46,3.92,;-4.46,2.38,;-5.8,1.61,;-7.13,2.38,;4.79,-.07,;6.12,-.84,;7.45,-.07,;7.45,1.47,;8.79,2.24,;6.12,2.24,;4.79,1.47,)| Show InChI InChI=1S/C26H31N7O5S/c1-7-38-23(24-28-13-17(3)14-29-24)18(4)39(34,35)32-26-31-30-25(19-11-16(2)12-27-15-19)33(26)22-20(36-5)9-8-10-21(22)37-6/h8-15,18,23H,7H2,1-6H3,(H,31,32)/t18-,23-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 0.800 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US9845310 (2017)
BindingDB Entry DOI: 10.7270/Q28P62TV |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM359969
((2R)-2-(4-chlorophenyl)-N-(4-(2,6-dimethoxyphenyl)...)Show SMILES COc1cccc(n1)-c1nnc(N(CC[Si](C)(C)C)S(=O)(=O)C[C@H](O)c2ccc(Cl)cc2)n1-c1c(OC)cccc1OC |r,wU:23.24,(-8.84,1.66,;-9.16,3.16,;-8.02,4.19,;-8.34,5.7,;-7.19,6.73,;-5.73,6.25,;-5.41,4.75,;-6.55,3.72,;-3.94,4.27,;-3.47,2.81,;-1.93,2.81,;-1.45,4.27,;.01,4.75,;.33,6.25,;1.87,6.42,;2.49,7.83,;4.02,8,;1.58,9.07,;3.11,9.24,;1.16,3.72,;1.56,2.23,;.07,2.63,;2.49,4.49,;3.83,3.72,;3.83,2.18,;5.16,4.49,;6.49,3.72,;7.83,4.49,;7.83,6.03,;9.16,6.8,;6.49,6.8,;5.16,6.03,;-2.7,5.18,;-2.7,6.72,;-4.03,7.49,;-5.36,6.72,;-6.7,7.49,;-4.03,9.03,;-2.7,9.8,;-1.36,9.03,;-1.36,7.49,;-.03,6.72,;1.3,7.49,)| Show InChI InChI=1S/C29H36ClN5O6SSi/c1-39-24-10-8-11-25(40-2)27(24)35-28(22-9-7-12-26(31-22)41-3)32-33-29(35)34(17-18-43(4,5)6)42(37,38)19-23(36)20-13-15-21(30)16-14-20/h7-16,23,36H,17-19H2,1-6H3/t23-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 0.340 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US9845310 (2017)
BindingDB Entry DOI: 10.7270/Q28P62TV |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM269748
((R)—N-(4-(2,6-dimethoxyphenyl)-5-(6-methoxypy...)Show SMILES COc1cccc(n1)-c1nnc(NS(=O)(=O)C[C@@H](O)c2ccc(F)cc2S(C)(=O)=O)n1-c1c(OC)cccc1OC |r,wD:17.18,(-8.29,-9.17,;-8.68,-7.68,;-7.59,-6.59,;-7.99,-5.11,;-6.89,-4.02,;-5.41,-4.42,;-5.01,-5.91,;-6.1,-7,;-3.68,-6.68,;-3.2,-8.14,;-1.66,-8.14,;-1.19,-6.68,;.15,-5.91,;1.48,-6.68,;.71,-8.01,;2.25,-8.01,;2.81,-5.91,;4.15,-6.68,;4.15,-8.22,;5.48,-5.91,;5.48,-4.37,;6.82,-3.6,;8.15,-4.37,;9.48,-3.6,;8.15,-5.91,;6.82,-6.68,;6.82,-8.22,;5.48,-8.99,;8.15,-8.99,;8.15,-7.45,;-2.43,-5.77,;-2.43,-3.69,;-3.77,-2.92,;-5.1,-3.69,;-6.43,-2.92,;-3.77,-1.38,;-2.43,-.61,;-1.1,-1.38,;-1.1,-2.92,;.24,-3.69,;1.57,-2.92,)| Show InChI InChI=1S/C25H26FN5O8S2/c1-37-19-8-6-9-20(38-2)23(19)31-24(17-7-5-10-22(27-17)39-3)28-29-25(31)30-41(35,36)14-18(32)16-12-11-15(26)13-21(16)40(4,33)34/h5-13,18,32H,14H2,1-4H3,(H,29,30)/t18-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 0.170 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US9845310 (2017)
BindingDB Entry DOI: 10.7270/Q28P62TV |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM269750
((R)—N-(4-(2,6-dimethoxyphenyl)-5-(6-methoxypy...)Show SMILES COc1cccc(n1)-c1nnc(NS(=O)(=O)C[C@@H](O)c2ccc(F)cc2)n1-c1c(OC)cccc1OC |r,wD:17.18,(-8.69,-9.29,;-9.08,-7.8,;-7.99,-6.71,;-8.39,-5.22,;-7.3,-4.14,;-5.81,-4.54,;-5.41,-6.03,;-6.5,-7.11,;-4.08,-6.8,;-3.6,-8.26,;-2.06,-8.26,;-1.59,-6.8,;-.25,-6.03,;1.08,-6.8,;.31,-8.13,;1.85,-8.13,;2.41,-6.03,;3.75,-6.8,;3.75,-8.34,;5.08,-6.03,;6.41,-6.8,;7.75,-6.03,;7.75,-4.49,;9.08,-3.72,;6.41,-3.72,;5.08,-4.49,;-2.83,-5.89,;-2.83,-3.81,;-4.17,-3.04,;-5.5,-3.81,;-6.83,-3.04,;-4.17,-1.5,;-2.83,-.73,;-1.5,-1.5,;-1.5,-3.04,;-.17,-3.81,;1.17,-3.04,)| Show InChI InChI=1S/C24H24FN5O6S/c1-34-19-7-5-8-20(35-2)22(19)30-23(17-6-4-9-21(26-17)36-3)27-28-24(30)29-37(32,33)14-18(31)15-10-12-16(25)13-11-15/h4-13,18,31H,14H2,1-3H3,(H,28,29)/t18-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 0.75 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US9845310 (2017)
BindingDB Entry DOI: 10.7270/Q28P62TV |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM269755
((R)-2-(2-cyano-4-fluorophenyl)-N-(4-(2,6-dimethoxy...)Show SMILES CO[C@H](CS(=O)(=O)N(CC[Si](C)(C)C)c1nnc(-c2cccc(OC)n2)n1-c1c(OC)cccc1OC)c1ccc(F)cc1Br |r,wD:2.1,(2.9,-11.43,;4.23,-10.66,;4.23,-9.12,;2.9,-8.35,;1.56,-9.12,;.79,-10.45,;2.33,-10.45,;.23,-8.35,;.63,-6.86,;2.12,-6.46,;2.51,-4.97,;4,-4.57,;1.43,-3.88,;2.91,-3.48,;-1.1,-9.12,;-1.58,-10.58,;-3.12,-10.58,;-3.6,-9.12,;-4.93,-8.35,;-5.33,-6.86,;-6.81,-6.46,;-7.9,-7.54,;-7.51,-9.03,;-8.6,-10.12,;-8.2,-11.61,;-6.02,-9.43,;-2.35,-8.21,;-2.35,-3.78,;-3.68,-3.01,;-5.02,-3.78,;-6.35,-3.01,;-3.68,-1.47,;-2.35,-.7,;-1.02,-1.47,;-1.02,-3.01,;.32,-3.78,;1.65,-3.01,;5.56,-8.35,;5.56,-6.81,;6.9,-6.04,;8.23,-6.81,;9.57,-6.04,;8.23,-8.35,;6.9,-9.12,;6.9,-10.66,)| Show InChI InChI=1S/C30H37BrFN5O6SSi/c1-40-24-11-9-12-25(41-2)28(24)37-29(23-10-8-13-27(33-23)43-4)34-35-30(37)36(16-17-45(5,6)7)44(38,39)19-26(42-3)21-15-14-20(32)18-22(21)31/h8-15,18,26H,16-17,19H2,1-7H3/t26-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 0.210 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US9845310 (2017)
BindingDB Entry DOI: 10.7270/Q28P62TV |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM269763
((1R,2S)—N-(4-(2,6-dimethoxyphenyl)-5-(6-metho...)Show SMILES COc1cccc(n1)-c1nnc(NS(=O)(=O)[C@@H](C)[C@@H](O)c2ccc(F)cc2)n1-c1c(OC)cccc1OC |r,wU:16.17,wD:18.19,(-9.25,-20.18,;-8.85,-18.69,;-7.36,-18.3,;-6.96,-16.81,;-5.47,-16.41,;-4.39,-17.5,;-4.78,-18.99,;-6.27,-19.38,;-3.7,-20.08,;-3.7,-21.62,;-2.23,-22.09,;-1.33,-20.85,;.21,-20.85,;.98,-22.18,;1.75,-23.51,;-.35,-22.95,;2.32,-21.41,;2.32,-19.87,;3.65,-22.18,;3.65,-23.72,;4.99,-21.41,;6.32,-22.18,;7.65,-21.41,;7.65,-19.87,;8.99,-19.1,;6.32,-19.1,;4.99,-19.87,;-2.23,-19.6,;-1.47,-16.75,;-2.56,-15.66,;-4.04,-16.06,;-5.13,-14.97,;-2.16,-14.17,;-.67,-13.77,;.42,-14.86,;.02,-16.35,;1.11,-17.44,;2.6,-17.04,)| Show InChI InChI=1S/C25H26FN5O6S/c1-15(23(32)16-11-13-17(26)14-12-16)38(33,34)30-25-29-28-24(18-7-5-10-21(27-18)37-4)31(25)22-19(35-2)8-6-9-20(22)36-3/h5-15,23,32H,1-4H3,(H,29,30)/t15-,23+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 13 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US9845310 (2017)
BindingDB Entry DOI: 10.7270/Q28P62TV |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM269774
((1S,2S)—N-(4-(2,6-dimethoxyphenyl)-5-(5-methy...)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@@H](O)c2nc(C)c(C)s2)nnc1-c1cncc(C)c1 |r,wU:16.17,wD:18.19,(3,-3.99,;4.33,-4.76,;5.67,-3.99,;5.67,-2.45,;7,-1.68,;8.33,-2.45,;8.33,-3.99,;9.67,-4.76,;11,-3.99,;7,-4.76,;7,-6.3,;8.25,-7.21,;9.58,-6.44,;10.67,-7.52,;9.9,-8.86,;11.44,-8.86,;12.16,-7.13,;12.56,-5.64,;13.25,-8.22,;12.85,-9.7,;14.73,-7.82,;15.98,-8.72,;17.23,-7.82,;18.56,-8.59,;16.75,-6.35,;17.52,-5.02,;15.21,-6.35,;7.77,-8.67,;6.23,-8.67,;5.76,-7.21,;4.22,-7.21,;3.45,-8.54,;1.91,-8.54,;1.14,-7.21,;1.91,-5.87,;1.14,-4.54,;3.45,-5.87,)| Show InChI InChI=1S/C24H28N6O5S2/c1-13-10-17(12-25-11-13)22-27-28-24(30(22)20-18(34-5)8-7-9-19(20)35-6)29-37(32,33)16(4)21(31)23-26-14(2)15(3)36-23/h7-12,16,21,31H,1-6H3,(H,28,29)/t16-,21+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 98 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US9845310 (2017)
BindingDB Entry DOI: 10.7270/Q28P62TV |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM269774
((1S,2S)—N-(4-(2,6-dimethoxyphenyl)-5-(5-methy...)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@@H](O)c2nc(C)c(C)s2)nnc1-c1cncc(C)c1 |r,wU:16.17,wD:18.19,(3,-3.99,;4.33,-4.76,;5.67,-3.99,;5.67,-2.45,;7,-1.68,;8.33,-2.45,;8.33,-3.99,;9.67,-4.76,;11,-3.99,;7,-4.76,;7,-6.3,;8.25,-7.21,;9.58,-6.44,;10.67,-7.52,;9.9,-8.86,;11.44,-8.86,;12.16,-7.13,;12.56,-5.64,;13.25,-8.22,;12.85,-9.7,;14.73,-7.82,;15.98,-8.72,;17.23,-7.82,;18.56,-8.59,;16.75,-6.35,;17.52,-5.02,;15.21,-6.35,;7.77,-8.67,;6.23,-8.67,;5.76,-7.21,;4.22,-7.21,;3.45,-8.54,;1.91,-8.54,;1.14,-7.21,;1.91,-5.87,;1.14,-4.54,;3.45,-5.87,)| Show InChI InChI=1S/C24H28N6O5S2/c1-13-10-17(12-25-11-13)22-27-28-24(30(22)20-18(34-5)8-7-9-19(20)35-6)29-37(32,33)16(4)21(31)23-26-14(2)15(3)36-23/h7-12,16,21,31H,1-6H3,(H,28,29)/t16-,21+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 4.70 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US9845310 (2017)
BindingDB Entry DOI: 10.7270/Q28P62TV |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM363199
((1R,2S)-N-(4-(2,6-dimethoxyphenyl)-5-(5-methylpyri...)Show SMILES COc1cnc(cn1)[C@@H](O)[C@H](C)S(=O)(=O)Nc1nnc(-c2cncc(C)c2)n1-c1c(OC)cccc1OC |r,wU:10.11,8.9,(-1.48,3.63,;-2.57,4.71,;-4.06,4.32,;-4.46,2.83,;-5.95,2.43,;-7.03,3.52,;-6.64,5.01,;-5.15,5.4,;-8.52,3.12,;-8.92,1.63,;-9.61,4.21,;-9.21,5.7,;-11.1,3.81,;-11.87,2.48,;-10.33,2.48,;-12.19,4.9,;-13.68,4.5,;-14.15,3.04,;-15.69,3.04,;-16.17,4.5,;-17.71,4.5,;-18.48,3.17,;-20.02,3.17,;-20.79,4.5,;-20.02,5.83,;-20.79,7.17,;-18.48,5.83,;-14.92,5.41,;-14.92,6.95,;-16.25,7.72,;-17.59,6.95,;-18.92,7.72,;-16.25,9.26,;-14.92,10.03,;-13.59,9.26,;-13.59,7.72,;-12.25,6.95,;-10.92,7.72,)| Show InChI InChI=1S/C24H27N7O6S/c1-14-9-16(11-25-10-14)23-28-29-24(31(23)21-18(35-3)7-6-8-19(21)36-4)30-38(33,34)15(2)22(32)17-12-27-20(37-5)13-26-17/h6-13,15,22,32H,1-5H3,(H,29,30)/t15-,22-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 9.5 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US9845310 (2017)
BindingDB Entry DOI: 10.7270/Q28P62TV |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM269806
((2R)—N-(4-(2,6-dimethoxyphenyl)-5-(6-methoxy-...)Show SMILES CO[C@H](CS(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1-c1c(OC)cccc1OC)c1ccc(F)cn1 |r,wD:2.1,(7.77,-13.93,;6.23,-13.93,;5.46,-12.6,;3.92,-12.6,;3.15,-13.93,;2.38,-15.26,;4.49,-14.7,;1.82,-13.16,;.49,-13.93,;.49,-15.47,;-.98,-15.95,;-1.88,-14.7,;-3.37,-14.3,;-3.77,-12.81,;-5.26,-12.42,;-6.35,-13.5,;-5.95,-14.99,;-7.04,-16.08,;-6.64,-17.57,;-4.46,-15.39,;-.98,-13.45,;-1.55,-11.31,;-.46,-10.22,;1.02,-10.62,;2.11,-9.53,;-.86,-8.74,;-2.35,-8.34,;-3.44,-9.43,;-3.04,-10.91,;-4.13,-12,;-5.62,-11.6,;6.23,-11.26,;5.46,-9.93,;6.23,-8.6,;7.77,-8.6,;8.54,-7.26,;8.54,-9.93,;7.77,-11.26,)| Show InChI InChI=1S/C24H25FN6O6S/c1-34-18-8-6-9-19(35-2)22(18)31-23(17-7-5-10-21(27-17)37-4)28-29-24(31)30-38(32,33)14-20(36-3)16-12-11-15(25)13-26-16/h5-13,20H,14H2,1-4H3,(H,29,30)/t20-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 0.300 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US9845310 (2017)
BindingDB Entry DOI: 10.7270/Q28P62TV |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM269811
((2R)—N-(4-(2,6-dimethoxyphenyl)-5-(6-methoxy-...)Show SMILES COc1cccc(n1)-c1nnc(NS(=O)(=O)C[C@@H](O)c2cc(C)on2)n1-c1c(OC)cccc1OC |r,wD:17.18,(-7.17,-15.16,;-7.57,-13.68,;-6.48,-12.59,;-6.88,-11.1,;-5.79,-10.01,;-4.3,-10.41,;-3.91,-11.9,;-4.99,-12.99,;-2.57,-12.67,;-2.1,-14.13,;-.56,-14.13,;-.08,-12.67,;1.25,-11.9,;2.59,-12.67,;1.5,-13.76,;3.68,-13.76,;3.68,-11.58,;5.16,-11.98,;5.56,-13.46,;6.25,-10.89,;6.25,-9.35,;7.72,-8.87,;8.49,-7.54,;8.62,-10.12,;7.72,-11.36,;-1.33,-11.76,;-1.33,-9.86,;-2.66,-9.09,;-3.99,-9.86,;-5.33,-9.09,;-2.66,-7.55,;-1.33,-6.78,;.01,-7.55,;.01,-9.09,;1.34,-9.86,;2.67,-9.09,)| Show InChI InChI=1S/C22H24N6O7S/c1-13-11-15(26-35-13)16(29)12-36(30,31)27-22-25-24-21(14-7-5-10-19(23-14)34-4)28(22)20-17(32-2)8-6-9-18(20)33-3/h5-11,16,29H,12H2,1-4H3,(H,25,27)/t16-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 0.990 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US9845310 (2017)
BindingDB Entry DOI: 10.7270/Q28P62TV |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM269814
((2R)—N-(4-(2,6-dimethoxyphenyl)-5-(6-methoxy-...)Show SMILES COc1cccc(n1)-c1nnc(NS(=O)(=O)C[C@@H](O)c2cc(C)no2)n1-c1c(OC)cccc1OC |r,wD:17.18,(-7.29,-14.62,;-7.69,-13.13,;-6.6,-12.04,;-7,-10.55,;-5.91,-9.46,;-4.42,-9.86,;-4.02,-11.35,;-5.11,-12.44,;-2.69,-12.12,;-2.21,-13.58,;-.67,-13.58,;-.2,-12.12,;1.14,-11.35,;2.47,-12.12,;1.38,-13.21,;3.56,-13.21,;3.56,-11.03,;5.05,-11.43,;5.44,-12.92,;6.13,-10.34,;6.13,-8.8,;7.6,-8.32,;8.37,-6.99,;8.5,-9.57,;7.6,-10.81,;-1.44,-11.21,;-1.44,-9.31,;-2.78,-8.54,;-4.11,-9.31,;-5.45,-8.54,;-2.78,-7,;-1.44,-6.23,;-.11,-7,;-.11,-8.54,;1.22,-9.31,;2.56,-8.54,)| Show InChI InChI=1S/C22H24N6O7S/c1-13-11-18(35-26-13)15(29)12-36(30,31)27-22-25-24-21(14-7-5-10-19(23-14)34-4)28(22)20-16(32-2)8-6-9-17(20)33-3/h5-11,15,29H,12H2,1-4H3,(H,25,27)/t15-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 4 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US9845310 (2017)
BindingDB Entry DOI: 10.7270/Q28P62TV |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM269816
((2R)—N-(4-(2,6-dimethoxyphenyl)-5-(6-methoxy-...)Show SMILES COc1cccc(n1)-c1nnc(NS(=O)(=O)C[C@@H](O)c2ncc(C)cn2)n1-c1c(OC)cccc1OC |r,wD:17.18,(-7.61,-14.86,;-8.01,-13.38,;-6.92,-12.29,;-7.32,-10.8,;-6.23,-9.71,;-4.74,-10.11,;-4.34,-11.6,;-5.43,-12.69,;-3.01,-12.37,;-2.53,-13.83,;-.99,-13.83,;-.52,-12.37,;.82,-11.6,;2.15,-12.37,;1.06,-13.46,;3.24,-13.46,;3.24,-11.28,;4.73,-11.68,;5.13,-13.16,;5.82,-10.59,;7.3,-10.99,;8.39,-9.9,;7.99,-8.41,;9.08,-7.32,;6.51,-8.01,;5.42,-9.1,;-1.76,-11.46,;-1.76,-9.56,;-3.1,-8.79,;-4.43,-9.56,;-5.76,-8.79,;-3.1,-7.25,;-1.76,-6.48,;-.43,-7.25,;-.43,-8.79,;.91,-9.56,;2.24,-8.79,)| Show InChI InChI=1S/C23H25N7O6S/c1-14-11-24-21(25-12-14)16(31)13-37(32,33)29-23-28-27-22(15-7-5-10-19(26-15)36-4)30(23)20-17(34-2)8-6-9-18(20)35-3/h5-12,16,31H,13H2,1-4H3,(H,28,29)/t16-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 0.700 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US9845310 (2017)
BindingDB Entry DOI: 10.7270/Q28P62TV |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM269835
((1R,2R)—N-(4-(2,6-dimethoxyphenyl)-5-(5-methy...)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@@H](O)c2ncc(F)cn2)nnc1-c1cncc(C)c1 |r,wU:16.17,wD:18.19,(1.83,-6.71,;.49,-7.48,;-.84,-6.71,;-.89,-5.14,;-2.22,-4.37,;-3.56,-5.14,;-3.56,-6.68,;-4.89,-7.45,;-6.22,-6.68,;-2.22,-7.45,;-2.22,-8.99,;-.98,-9.9,;.36,-9.13,;1.69,-9.9,;.92,-11.23,;2.46,-11.23,;3.03,-9.13,;3.03,-7.59,;4.36,-9.9,;4.36,-11.44,;5.69,-9.13,;7.03,-9.9,;8.36,-9.13,;8.36,-7.59,;9.69,-6.82,;7.03,-6.82,;5.69,-7.59,;-1.45,-11.36,;-2.99,-11.36,;-3.47,-9.9,;-4.95,-9.5,;-5.72,-10.83,;-7.26,-10.83,;-8.03,-9.5,;-7.26,-8.16,;-8.03,-6.83,;-5.72,-8.16,)| Show InChI InChI=1S/C23H24FN7O5S/c1-13-8-15(10-25-9-13)22-28-29-23(31(22)19-17(35-3)6-5-7-18(19)36-4)30-37(33,34)14(2)20(32)21-26-11-16(24)12-27-21/h5-12,14,20,32H,1-4H3,(H,29,30)/t14-,20+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 69 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US9845310 (2017)
BindingDB Entry DOI: 10.7270/Q28P62TV |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM269835
((1R,2R)—N-(4-(2,6-dimethoxyphenyl)-5-(5-methy...)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@@H](O)c2ncc(F)cn2)nnc1-c1cncc(C)c1 |r,wU:16.17,wD:18.19,(1.83,-6.71,;.49,-7.48,;-.84,-6.71,;-.89,-5.14,;-2.22,-4.37,;-3.56,-5.14,;-3.56,-6.68,;-4.89,-7.45,;-6.22,-6.68,;-2.22,-7.45,;-2.22,-8.99,;-.98,-9.9,;.36,-9.13,;1.69,-9.9,;.92,-11.23,;2.46,-11.23,;3.03,-9.13,;3.03,-7.59,;4.36,-9.9,;4.36,-11.44,;5.69,-9.13,;7.03,-9.9,;8.36,-9.13,;8.36,-7.59,;9.69,-6.82,;7.03,-6.82,;5.69,-7.59,;-1.45,-11.36,;-2.99,-11.36,;-3.47,-9.9,;-4.95,-9.5,;-5.72,-10.83,;-7.26,-10.83,;-8.03,-9.5,;-7.26,-8.16,;-8.03,-6.83,;-5.72,-8.16,)| Show InChI InChI=1S/C23H24FN7O5S/c1-13-8-15(10-25-9-13)22-28-29-23(31(22)19-17(35-3)6-5-7-18(19)36-4)30-37(33,34)14(2)20(32)21-26-11-16(24)12-27-21/h5-12,14,20,32H,1-4H3,(H,29,30)/t14-,20+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 4.80 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US9845310 (2017)
BindingDB Entry DOI: 10.7270/Q28P62TV |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM360069
((1R,2R)-N-(4-(2,6-dimethoxyphenyl)-5-(6-methoxy-2-...)Show SMILES COc1cccc(n1)-c1nnc(NS(=O)(=O)[C@@H](C)[C@@H](O)c2ncc(F)cn2)n1-c1c(OC)cccc1OC |r,wU:16.17,wD:18.19,(-9.69,-9.54,;-8.17,-9.8,;-7.4,-8.47,;-8.17,-7.14,;-7.4,-5.8,;-5.86,-5.8,;-5.09,-7.14,;-5.86,-8.47,;-3.76,-7.91,;-3.28,-9.37,;-1.74,-9.37,;-1.26,-7.91,;.22,-7.51,;1.56,-8.28,;.79,-9.61,;2.33,-9.61,;2.89,-7.51,;2.89,-5.97,;4.22,-8.28,;4.22,-9.82,;5.56,-7.51,;6.89,-8.28,;8.22,-7.51,;8.22,-5.97,;9.56,-5.2,;6.89,-5.2,;5.56,-5.97,;-2.51,-7,;-2.51,-4.34,;-1.13,-3.6,;.2,-4.37,;1.54,-3.6,;-1.18,-2.03,;-2.51,-1.26,;-3.84,-2.03,;-3.84,-3.57,;-5.18,-4.34,;-6.36,-3.35,)| Show InChI InChI=1S/C23H24FN7O6S/c1-13(20(32)21-25-11-14(24)12-26-21)38(33,34)30-23-29-28-22(15-7-5-10-18(27-15)37-4)31(23)19-16(35-2)8-6-9-17(19)36-3/h5-13,20,32H,1-4H3,(H,29,30)/t13-,20+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 0.280 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US9845310 (2017)
BindingDB Entry DOI: 10.7270/Q28P62TV |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM269843
((S)-2-(2,4-difluorophenyl)-N-(4-(2,6-dimethoxyphen...)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)C[C@H](O)c2ccc(F)cc2F)nnc1-c1cncc(C)c1 |r,wU:17.18,(1.32,-8.51,;-.01,-9.28,;-1.35,-8.51,;-1.39,-6.95,;-2.73,-6.18,;-4.06,-6.95,;-4.06,-8.49,;-5.39,-9.26,;-6.73,-8.49,;-2.73,-9.26,;-2.73,-11.16,;-1.48,-12.06,;-.15,-11.29,;1.19,-12.06,;.42,-13.4,;1.96,-13.4,;2.52,-11.29,;3.85,-12.06,;3.85,-13.6,;5.19,-11.29,;5.19,-9.75,;6.52,-8.98,;7.85,-9.75,;9.19,-8.98,;7.85,-11.29,;6.52,-12.06,;6.52,-13.6,;-1.96,-13.53,;-3.5,-13.53,;-3.97,-12.06,;-5.31,-11.29,;-6.08,-12.63,;-7.62,-12.63,;-8.39,-11.29,;-7.62,-9.96,;-8.39,-8.63,;-6.08,-9.96,)| Show InChI InChI=1S/C24H23F2N5O5S/c1-14-9-15(12-27-11-14)23-28-29-24(31(23)22-20(35-2)5-4-6-21(22)36-3)30-37(33,34)13-19(32)17-8-7-16(25)10-18(17)26/h4-12,19,32H,13H2,1-3H3,(H,29,30)/t19-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 1.10 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US9845310 (2017)
BindingDB Entry DOI: 10.7270/Q28P62TV |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM269868
((1S,2R)—N-(4-(2,6-dimethoxyphenyl)-5-(5-methy...)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](OCCO)c2ncc(C)cn2)nnc1-c1cncc(C)c1 |r,wU:18.19,16.17,(1.57,-2.91,;.24,-3.68,;-1.1,-2.91,;-1.14,-1.35,;-2.48,-.58,;-3.81,-1.35,;-3.81,-2.89,;-5.15,-3.66,;-6.48,-2.89,;-2.48,-3.66,;-2.48,-5.2,;-1.23,-6.1,;.1,-5.33,;1.44,-6.1,;.67,-7.43,;2.21,-7.43,;2.77,-5.33,;2.77,-3.79,;4.1,-6.1,;4.1,-7.64,;5.44,-8.41,;5.44,-9.95,;6.77,-10.72,;5.44,-5.33,;6.77,-6.1,;8.1,-5.33,;8.1,-3.79,;9.44,-3.02,;6.77,-3.02,;5.44,-3.79,;-1.71,-7.57,;-3.25,-7.57,;-3.72,-6.1,;-5.21,-5.7,;-5.98,-7.04,;-7.52,-7.04,;-8.29,-5.7,;-7.52,-4.37,;-8.29,-3.04,;-5.98,-4.37,)| Show InChI InChI=1S/C26H31N7O6S/c1-16-11-19(15-27-12-16)25-30-31-26(33(25)22-20(37-4)7-6-8-21(22)38-5)32-40(35,36)18(3)23(39-10-9-34)24-28-13-17(2)14-29-24/h6-8,11-15,18,23,34H,9-10H2,1-5H3,(H,31,32)/t18-,23-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 12 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US9845310 (2017)
BindingDB Entry DOI: 10.7270/Q28P62TV |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM269881
((1S,2S)—N-(4-(2,6-dimethoxyphenyl)-5-(5-methy...)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@H](C)[C@H](OCC(C)(C)O)c2ncc(C)cn2)nnc1-c1cncc(C)c1 |r,wU:18.19,wD:16.17,(1.28,-3.3,;-.05,-4.07,;-1.39,-3.3,;-1.44,-1.74,;-2.77,-.97,;-4.1,-1.74,;-4.1,-3.28,;-5.44,-4.05,;-6.77,-3.28,;-2.77,-4.05,;-2.77,-5.77,;-1.52,-6.67,;-.19,-5.9,;1.14,-6.67,;1.91,-8.01,;.37,-8.01,;2.48,-5.9,;2.48,-4.36,;3.81,-6.67,;3.81,-8.21,;5.14,-8.98,;5.14,-10.52,;6.48,-11.29,;5.14,-12.06,;3.81,-11.29,;5.14,-5.9,;5.14,-4.36,;6.48,-3.59,;7.81,-4.36,;9.15,-3.59,;7.81,-5.9,;6.48,-6.67,;-2,-8.14,;-3.54,-8.14,;-4.02,-6.67,;-5.35,-5.9,;-6.12,-7.24,;-7.66,-7.24,;-8.43,-5.9,;-7.66,-4.57,;-8.43,-3.24,;-6.12,-4.57,)| Show InChI InChI=1S/C28H35N7O6S/c1-17-11-20(15-29-12-17)26-32-33-27(35(26)23-21(39-6)9-8-10-22(23)40-7)34-42(37,38)19(3)24(41-16-28(4,5)36)25-30-13-18(2)14-31-25/h8-15,19,24,36H,16H2,1-7H3,(H,33,34)/t19-,24+/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 3.30 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US9845310 (2017)
BindingDB Entry DOI: 10.7270/Q28P62TV |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM269883
(1S,2S)—N-(4-(2,6-dimethoxyphenyl)-5-(5-methyl...)Show SMILES COCCO[C@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cncc(C)c2)n1-c1c(OC)cccc1OC)c1ncc(C)cn1 |r,wU:6.6,wD:5.4,(6.48,-13.22,;6.48,-11.68,;5.14,-10.91,;5.14,-9.37,;3.81,-8.6,;3.81,-7.06,;2.48,-6.29,;2.48,-4.75,;1.14,-7.06,;1.91,-8.39,;.37,-8.39,;-.19,-6.29,;-1.52,-7.06,;-2,-8.52,;-3.54,-8.52,;-4.02,-7.06,;-5.35,-6.29,;-6.12,-7.62,;-7.66,-7.62,;-8.43,-6.29,;-7.66,-4.95,;-8.43,-3.62,;-6.12,-4.95,;-2.77,-6.15,;-2.77,-4.43,;-1.39,-3.69,;-.05,-4.46,;1.28,-3.69,;-1.44,-2.12,;-2.77,-1.35,;-4.1,-2.12,;-4.1,-3.66,;-5.44,-4.43,;-6.77,-3.66,;5.14,-6.29,;5.14,-4.75,;6.48,-3.98,;7.81,-4.75,;9.15,-3.98,;7.81,-6.29,;6.48,-7.06,)| Show InChI InChI=1S/C27H33N7O6S/c1-17-12-20(16-28-13-17)26-31-32-27(34(26)23-21(38-5)8-7-9-22(23)39-6)33-41(35,36)19(3)24(40-11-10-37-4)25-29-14-18(2)15-30-25/h7-9,12-16,19,24H,10-11H2,1-6H3,(H,32,33)/t19-,24+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 0.460 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US9845310 (2017)
BindingDB Entry DOI: 10.7270/Q28P62TV |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM269884
((1S,2R)—N-(4-(2,6-dimethoxyphenyl)-5-(6-metho...)Show SMILES COc1cccc(n1)-c1nnc(NS(=O)(=O)[C@@H](C)[C@H](OCCO)c2ncc(C)cn2)n1-c1c(OC)cccc1OC |r,wU:18.19,16.17,(-9.97,-9.05,;-8.43,-9.05,;-7.66,-7.71,;-8.43,-6.38,;-7.66,-5.04,;-6.12,-5.04,;-5.35,-6.38,;-6.12,-7.71,;-4.02,-7.15,;-3.54,-8.61,;-2,-8.61,;-1.52,-7.15,;-.19,-6.38,;1.14,-7.15,;1.91,-8.48,;.37,-8.48,;2.48,-6.38,;2.48,-4.84,;3.81,-7.15,;3.81,-8.69,;5.14,-9.46,;5.14,-11,;6.48,-11.77,;5.14,-6.38,;5.14,-4.84,;6.48,-4.07,;7.81,-4.84,;9.15,-4.07,;7.81,-6.38,;6.48,-7.15,;-2.77,-6.24,;-2.77,-4.52,;-1.39,-3.78,;-.05,-4.55,;1.28,-3.78,;-1.44,-2.21,;-2.77,-1.44,;-4.1,-2.21,;-4.1,-3.75,;-5.44,-4.52,;-6.77,-3.75,)| Show InChI InChI=1S/C26H31N7O7S/c1-16-14-27-24(28-15-16)23(40-13-12-34)17(2)41(35,36)32-26-31-30-25(18-8-6-11-21(29-18)39-5)33(26)22-19(37-3)9-7-10-20(22)38-4/h6-11,14-15,17,23,34H,12-13H2,1-5H3,(H,31,32)/t17-,23-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 0.260 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US9845310 (2017)
BindingDB Entry DOI: 10.7270/Q28P62TV |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM269888
((2S)—N-(4-(2,6-dimethoxyphenyl)-5-(5-ethyl-3-...)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@H](C)Cc2ncc(F)cn2)nnc1-c1cncc(C=C)c1 |r,wD:16.17,(1.99,-3.97,;.66,-4.74,;-.68,-3.97,;-.68,-2.43,;-2.01,-1.66,;-3.34,-2.43,;-3.34,-3.97,;-4.68,-4.74,;-6.01,-3.97,;-2.01,-4.74,;-2.01,-6.28,;-.76,-7.19,;.57,-6.42,;1.9,-7.19,;2.67,-8.52,;1.13,-8.52,;3.24,-6.42,;3.24,-4.88,;4.57,-7.19,;5.9,-6.42,;5.9,-4.88,;7.24,-4.11,;8.57,-4.88,;9.9,-4.11,;8.57,-6.42,;7.24,-7.19,;-1.24,-8.65,;-2.78,-8.65,;-3.26,-7.19,;-4.8,-7.19,;-5.57,-8.52,;-7.11,-8.52,;-7.88,-7.19,;-7.11,-5.85,;-7.88,-4.52,;-9.42,-4.52,;-5.57,-5.85,)| Show InChI InChI=1S/C24H24FN7O4S/c1-5-16-10-17(12-26-11-16)23-29-30-24(32(23)22-19(35-3)7-6-8-20(22)36-4)31-37(33,34)15(2)9-21-27-13-18(25)14-28-21/h5-8,10-15H,1,9H2,2-4H3,(H,30,31)/t15-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 7.90 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US9845310 (2017)
BindingDB Entry DOI: 10.7270/Q28P62TV |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM269886
((2S)—N-(4-(2,6-dimethoxyphenyl)-5-(5-ethenyl-...)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)Cc2ncc(F)cn2)nnc1-c1cncc(C=C)c1 |r,wU:16.17,(2,-3.8,;.66,-4.57,;-.67,-3.8,;-.67,-2.26,;-2,-1.49,;-3.34,-2.26,;-3.34,-3.8,;-4.67,-4.57,;-6.01,-3.8,;-2,-4.57,;-2,-6.11,;-.76,-7.02,;.57,-6.25,;1.91,-7.02,;2.68,-8.35,;1.14,-8.35,;3.24,-6.25,;3.24,-4.71,;4.58,-7.02,;5.91,-6.25,;5.91,-4.71,;7.24,-3.94,;8.58,-4.71,;9.91,-3.94,;8.58,-6.25,;7.24,-7.02,;-1.23,-8.48,;-2.77,-8.48,;-3.25,-7.02,;-4.79,-7.02,;-5.56,-8.35,;-7.1,-8.35,;-7.87,-7.02,;-7.1,-5.68,;-7.87,-4.35,;-9.41,-4.35,;-5.56,-5.68,)| Show InChI InChI=1S/C24H24FN7O4S/c1-5-16-10-17(12-26-11-16)23-29-30-24(32(23)22-19(35-3)7-6-8-20(22)36-4)31-37(33,34)15(2)9-21-27-13-18(25)14-28-21/h5-8,10-15H,1,9H2,2-4H3,(H,30,31)/t15-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 6.70 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US9845310 (2017)
BindingDB Entry DOI: 10.7270/Q28P62TV |
More data for this
Ligand-Target Pair | |
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