| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Receptor-interacting serine/threonine-protein kinase 2 |
|---|
| Ligand | BDBM50279292 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1720614 (CHEMBL4135614) |
|---|
| IC50 | 12±n/a nM |
|---|
| Citation |  He, X; Da Ros, S; Nelson, J; Zhu, X; Jiang, T; Okram, B; Jiang, S; Michellys, PY; Iskandar, M; Espinola, S; Jia, Y; Bursulaya, B; Kreusch, A; Gao, MY; Spraggon, G; Baaten, J; Clemmer, L; Meeusen, S; Huang, D; Hill, R; Nguyen-Tran, V; Fathman, J; Liu, B; Tuntland, T; Gordon, P; Hollenbeck, T; Ng, K; Shi, J; Bordone, L; Liu, H Identification of Potent and Selective RIPK2 Inhibitors for the Treatment of Inflammatory Diseases. ACS Med Chem Lett8:1048-1053 (2017) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Receptor-interacting serine/threonine-protein kinase 2 |
|---|
| Name: | Receptor-interacting serine/threonine-protein kinase 2 |
|---|
| Synonyms: | 2.7.10.2 | 2.7.11.1 | RIPK2_MOUSE | Receptor-interacting serine/threonine-protein kinase 2 | Rip2 | Ripk2 | Tyrosine-protein kinase RIPK2 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 60406.99 |
|---|
| Organism: | Mus musculus |
|---|
| Description: | ChEMBL_118266 |
|---|
| Residue: | 539 |
|---|
| Sequence: | MNGDAICSALPPIPYHKLADLHYLSRGASGTVSSARHADWRVRVAVKHLHIHTPLLDSER
NDILREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDIAWPL
RFRILHEIALGVNYLHNMNPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRS
YKSAPEGGTIIYMPPENYEPGQKSRASVKHDIYSYAVIMWEVLSRKQPFEEVTNPLQIMY
SVSQGHRPDTSEENLPFDIPHRGLMISLIQSGWAQNPDERPSFLKCLIELEPVLRTFEDI
TFLEAVIQLKKAKIQSSSSTIHLCDKKMDLSLNIPANHPPQEESCGSSLLSRNTGSPGPS
RSLSAPQDKGFLSGAPQDCSSLKAHHCPGNHSWDGIVSVPPGAAFCDRRASSCSLAVISP
FLVEKGSERPPIGIAQQWIQSKREAIVSQMTEACLNQSLDALLSRDLIMKEDYELISTKP
TRTSKVRQLLDTSDIQGEEFAKVVVQKLKDNKQLGLQPYPEVPVLSKAPPSNFPQNKSL
|
|
|
|---|
| BDBM50279292 |
|---|
| n/a |
|---|
| Name | BDBM50279292 |
|---|
| Synonyms: | CHEMBL4161327 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C17H19FN4O3S |
|---|
| Mol. Mass. | 378.421 |
|---|
| SMILES | CCOc1cc2ncc(-c3cc(N)nc(F)c3)n2cc1S(=O)(=O)C(C)C |
|---|
| Structure | 
|
|---|
Search and Browse
