Reaction Details |
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Target | Neuraminidase |
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Ligand | BDBM50365357 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1735172 (CHEMBL4150708) |
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Ki | 4.0±n/a nM |
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Citation | Zhang, J; Poongavanam, V; Kang, D; Bertagnin, C; Lu, H; Kong, X; Ju, H; Lu, X; Gao, P; Tian, Y; Jia, H; Desta, S; Ding, X; Sun, L; Fang, Z; Huang, B; Liang, X; Jia, R; Ma, X; Xu, W; Murugan, NA; Loregian, A; Huang, B; Zhan, P; Liu, X Optimization of N-Substituted Oseltamivir Derivatives as Potent Inhibitors of Group-1 and -2 Influenza A Neuraminidases, Including a Drug-Resistant Variant. J Med Chem61:6379-6397 (2018) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Neuraminidase |
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Name: | Neuraminidase |
Synonyms: | NA | NRAM_I71A1 |
Type: | PROTEIN |
Mol. Mass.: | 52105.18 |
Organism: | Influenza A virus (strain A/Memphis/1/1971 H3N2) |
Description: | ChEMBL_578382 |
Residue: | 469 |
Sequence: | MNPNQKIITIGSVSLTIATVCFLMQIAILVTTVTLHFKQYECDSPANNQVMPCEPIIIER
NITEIVYLTNTTIEKEICPKLVEYRNWSKPQCKITGFAPFSKDNSIRLSAGGDIWVTREP
YVSCDPGKCYQFALGQGTTLDNKHSNDTIHDRIPHRTLLMNELGVPFHLGTRQVCIAWSS
SSCHDGKAWLHVCVTGDDKNATASFIYDGRLVDSIGSWSQNILRTQESECVCINGTCTVV
MTDGSASGRADTRILFIEEGKIVHISPLSGSAQHVEECSCYPRYPGVRCICRDNWKGSNR
PVVDINVKDYSIDSRYVCSGLVGDTPRNNDRSSNSNCRNPNNDKGNHGVKGWAFDDGNDV
WMGRTISKDSRSGYETFKVIGGWSTPNSKSQINRQVIVDSDNRSGYSGIFSVEGKSCINR
CFYVELIRGREQETRVWWTSNSIVVFCGTSGTYGTGSWPDGADINLMPI
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BDBM50365357 |
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n/a |
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Name | BDBM50365357 |
Synonyms: | CHEMBL4168935 |
Type | Small organic molecule |
Emp. Form. | C20H33N7O5 |
Mol. Mass. | 451.5199 |
SMILES | CCC(CC)O[C@@H]1C=C([C@@H]([C@H](NC(N)=N)[C@H]1NC(C)=O)n1cc(nn1)C(O)CC)C(O)=O |r,c:7| |
Structure |
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