Reaction Details | |||
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Target | Squalene synthase | ||
Ligand | BDBM50052357 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_202113 (CHEMBL808971) | ||
IC50 | 27±n/a nM | ||
Citation | Brown, GR; Clarke, DS; Foubister, AJ; Freeman, S; Harrison, PJ; Johnson, MC; Mallion, KB; McCormick, J; McTaggart, F; Reid, AC; Smith, GJ; Taylor, MJ Synthesis and activity of a novel series of 3-biarylquinuclidine squalene synthase inhibitors. J Med Chem39:2971-9 (1996) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Squalene synthase | |||
Name: | Squalene synthase | ||
Synonyms: | FDFT_RAT | FPP:FPP farnesyltransferase | Farnesyl-diphosphate farnesyltransferase | Fdft1 | SQS | SS | Squalene synthetase | ||
Type: | PROTEIN | ||
Mol. Mass.: | 48109.41 | ||
Organism: | Rattus norvegicus | ||
Description: | ChEMBL_1336736 | ||
Residue: | 416 | ||
Sequence: |
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BDBM50052357 | |||
n/a | |||
Name | BDBM50052357 | ||
Synonyms: | 3-Biphenyl-4-ylmethyl-1-aza-bicyclo[2.2.2]octane | 3-[1'-(Biphenyl)-methyl]-quinuclidine | CHEMBL99679 | ||
Type | Small organic molecule | ||
Emp. Form. | C20H23N | ||
Mol. Mass. | 277.4033 | ||
SMILES | C(C1CN2CCC1CC2)c1ccc(cc1)-c1ccccc1 |(24.24,-17.57,;22.91,-18.33,;22.91,-19.88,;21.57,-20.65,;20.23,-19.88,;20.23,-18.33,;21.57,-17.56,;20.83,-18.92,;22.32,-19.32,;25.58,-18.34,;25.57,-19.88,;26.9,-20.64,;28.23,-19.88,;28.23,-18.33,;26.9,-17.57,;29.56,-20.64,;29.56,-22.19,;30.89,-22.96,;32.23,-22.19,;32.22,-20.64,;30.89,-19.88,)| | ||
Structure |