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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Squalene synthase | ||
| Ligand | BDBM50052365 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_202113 (CHEMBL808971) | ||
| IC50 | >2500±n/a nM | ||
| Citation |  Brown, GR; Clarke, DS; Foubister, AJ; Freeman, S; Harrison, PJ; Johnson, MC; Mallion, KB; McCormick, J; McTaggart, F; Reid, AC; Smith, GJ; Taylor, MJ Synthesis and activity of a novel series of 3-biarylquinuclidine squalene synthase inhibitors. J Med Chem39:2971-9 (1996) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Squalene synthase | |||
| Name: | Squalene synthase | ||
| Synonyms: | FDFT_RAT | FPP:FPP farnesyltransferase | Farnesyl-diphosphate farnesyltransferase | Fdft1 | SQS | SS | Squalene synthetase | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 48109.41 | ||
| Organism: | Rattus norvegicus | ||
| Description: | ChEMBL_1336736 | ||
| Residue: | 416 | ||
| Sequence: |
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| BDBM50052365 | |||
| n/a | |||
| Name | BDBM50052365 | ||
| Synonyms: | 3-Biphenyl-4-yl-3-methoxy-1-aza-bicyclo[2.2.2]octane | CHEMBL102188 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C20H23NO | ||
| Mol. Mass. | 293.4027 | ||
| SMILES | COC1(CN2CCC1CC2)c1ccc(cc1)-c1ccccc1 |THB:10:2:6.5:8.9,1:2:6.5:8.9,(12.8,-6.52,;11.68,-7.17,;11.5,-9.25,;11.79,-10.63,;10.41,-10.01,;8.89,-10.66,;8.69,-9.28,;10.15,-8.64,;10.15,-6.94,;10.66,-8.12,;13.04,-9.25,;13.81,-7.92,;15.35,-7.92,;16.12,-9.25,;15.35,-10.6,;13.81,-10.6,;17.66,-9.25,;18.43,-10.59,;19.97,-10.59,;20.74,-9.25,;19.97,-7.9,;18.43,-7.92,)| | ||
| Structure | 
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