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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Squalene synthase | ||
| Ligand | BDBM50052374 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_202113 (CHEMBL808971) | ||
| IC50 | 270±n/a nM | ||
| Citation |  Brown, GR; Clarke, DS; Foubister, AJ; Freeman, S; Harrison, PJ; Johnson, MC; Mallion, KB; McCormick, J; McTaggart, F; Reid, AC; Smith, GJ; Taylor, MJ Synthesis and activity of a novel series of 3-biarylquinuclidine squalene synthase inhibitors. J Med Chem39:2971-9 (1996) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Squalene synthase | |||
| Name: | Squalene synthase | ||
| Synonyms: | FDFT_RAT | FPP:FPP farnesyltransferase | Farnesyl-diphosphate farnesyltransferase | Fdft1 | SQS | SS | Squalene synthetase | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 48109.41 | ||
| Organism: | Rattus norvegicus | ||
| Description: | ChEMBL_1336736 | ||
| Residue: | 416 | ||
| Sequence: |
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| BDBM50052374 | |||
| n/a | |||
| Name | BDBM50052374 | ||
| Synonyms: | 3-(4-Pyridin-3-yl-phenyl)-1-aza-bicyclo[2.2.2]octan-3-ol | CHEMBL322664 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C18H20N2O | ||
| Mol. Mass. | 280.3642 | ||
| SMILES | OC1(CN2CCC1CC2)c1ccc(cc1)-c1cccnc1 |TLB:9:1:5.4:7.8,0:1:5.4:7.8,(12.97,-8.1,;12.85,-10.02,;13.14,-11.51,;11.67,-10.84,;11.95,-8.79,;11.39,-7.51,;11.39,-9.36,;9.81,-10.05,;10.02,-11.54,;14.39,-10.04,;15.16,-11.36,;16.68,-11.36,;17.45,-10.04,;16.68,-8.7,;15.16,-8.7,;19,-10.02,;19.76,-8.7,;21.3,-8.7,;22.07,-10.02,;21.3,-11.36,;19.76,-11.37,)| | ||
| Structure | 
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