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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Squalene synthase | ||
| Ligand | BDBM50052369 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_202113 (CHEMBL808971) | ||
| IC50 | 2500±n/a nM | ||
| Citation |  Brown, GR; Clarke, DS; Foubister, AJ; Freeman, S; Harrison, PJ; Johnson, MC; Mallion, KB; McCormick, J; McTaggart, F; Reid, AC; Smith, GJ; Taylor, MJ Synthesis and activity of a novel series of 3-biarylquinuclidine squalene synthase inhibitors. J Med Chem39:2971-9 (1996) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Squalene synthase | |||
| Name: | Squalene synthase | ||
| Synonyms: | FDFT_RAT | FPP:FPP farnesyltransferase | Farnesyl-diphosphate farnesyltransferase | Fdft1 | SQS | SS | Squalene synthetase | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 48109.41 | ||
| Organism: | Rattus norvegicus | ||
| Description: | ChEMBL_1336736 | ||
| Residue: | 416 | ||
| Sequence: |
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| BDBM50052369 | |||
| n/a | |||
| Name | BDBM50052369 | ||
| Synonyms: | (1-Aza-bicyclo[2.2.2]oct-3-yl)-biphenyl-4-yl-methanol | CHEMBL101863 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C20H23NO | ||
| Mol. Mass. | 293.4027 | ||
| SMILES | OC(C1CN2CCC1CC2)c1ccc(cc1)-c1ccccc1 |TLB:1:2:8.9:6.5,(13.02,-8,;13.53,-9.45,;12.32,-10.4,;12.62,-11.9,;11.14,-11.23,;11.42,-9.17,;10.86,-7.89,;10.86,-9.74,;9.25,-10.44,;9.46,-11.94,;15.04,-9.45,;15.81,-8.1,;17.34,-8.1,;18.14,-9.45,;17.37,-10.78,;15.81,-10.78,;19.68,-9.43,;20.44,-8.1,;21.97,-8.1,;22.75,-9.43,;21.98,-10.78,;20.44,-10.78,)| | ||
| Structure | 
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