| Reaction Details |
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 | Report a problem with these data |
| Target | Neuraminidase |
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| Ligand | BDBM50365366 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1735175 (CHEMBL4150711) |
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| Ki | 219000±n/a nM |
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| Citation |  Zhang, J; Poongavanam, V; Kang, D; Bertagnin, C; Lu, H; Kong, X; Ju, H; Lu, X; Gao, P; Tian, Y; Jia, H; Desta, S; Ding, X; Sun, L; Fang, Z; Huang, B; Liang, X; Jia, R; Ma, X; Xu, W; Murugan, NA; Loregian, A; Huang, B; Zhan, P; Liu, X Optimization of N-Substituted Oseltamivir Derivatives as Potent Inhibitors of Group-1 and -2 Influenza A Neuraminidases, Including a Drug-Resistant Variant. J Med Chem61:6379-6397 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Neuraminidase |
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| Name: | Neuraminidase |
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| Synonyms: | NA | NRAM_I71A1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 52105.18 |
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| Organism: | Influenza A virus (strain A/Memphis/1/1971 H3N2) |
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| Description: | ChEMBL_578382 |
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| Residue: | 469 |
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| Sequence: | MNPNQKIITIGSVSLTIATVCFLMQIAILVTTVTLHFKQYECDSPANNQVMPCEPIIIER
NITEIVYLTNTTIEKEICPKLVEYRNWSKPQCKITGFAPFSKDNSIRLSAGGDIWVTREP
YVSCDPGKCYQFALGQGTTLDNKHSNDTIHDRIPHRTLLMNELGVPFHLGTRQVCIAWSS
SSCHDGKAWLHVCVTGDDKNATASFIYDGRLVDSIGSWSQNILRTQESECVCINGTCTVV
MTDGSASGRADTRILFIEEGKIVHISPLSGSAQHVEECSCYPRYPGVRCICRDNWKGSNR
PVVDINVKDYSIDSRYVCSGLVGDTPRNNDRSSNSNCRNPNNDKGNHGVKGWAFDDGNDV
WMGRTISKDSRSGYETFKVIGGWSTPNSKSQINRQVIVDSDNRSGYSGIFSVEGKSCINR
CFYVELIRGREQETRVWWTSNSIVVFCGTSGTYGTGSWPDGADINLMPI
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| BDBM50365366 |
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| n/a |
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| Name | BDBM50365366 |
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| Synonyms: | CHEMBL1232591 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H27NO8 |
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| Mol. Mass. | 421.441 |
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| SMILES | [H][C@]1(OC(C(O)=O)=C(C\C=C\c2ccc(C)cc2)[C@H](O)[C@H]1NC(C)=O)[C@H](O)[C@H](O)CO |r,t:6| |
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| Structure | 
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