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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Squalene synthase | ||
| Ligand | BDBM50052343 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_202113 (CHEMBL808971) | ||
| IC50 | 3±n/a nM | ||
| Citation |  Brown, GR; Clarke, DS; Foubister, AJ; Freeman, S; Harrison, PJ; Johnson, MC; Mallion, KB; McCormick, J; McTaggart, F; Reid, AC; Smith, GJ; Taylor, MJ Synthesis and activity of a novel series of 3-biarylquinuclidine squalene synthase inhibitors. J Med Chem39:2971-9 (1996) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Squalene synthase | |||
| Name: | Squalene synthase | ||
| Synonyms: | FDFT_RAT | FPP:FPP farnesyltransferase | Farnesyl-diphosphate farnesyltransferase | Fdft1 | SQS | SS | Squalene synthetase | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 48109.41 | ||
| Organism: | Rattus norvegicus | ||
| Description: | ChEMBL_1336736 | ||
| Residue: | 416 | ||
| Sequence: |
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| BDBM50052343 | |||
| n/a | |||
| Name | BDBM50052343 | ||
| Synonyms: | 3-Biphenyl-4-ylethynyl-1-aza-bicyclo[2.2.2]octan-3-ol | CHEMBL317462 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C21H21NO | ||
| Mol. Mass. | 303.3975 | ||
| SMILES | OC1(CN2CCC1CC2)C#Cc1ccc(cc1)-c1ccccc1 |THB:9:1:7.8:5.4,0:1:7.8:5.4,(8.8,-5.03,;8.54,-7.02,;8.83,-8.52,;7.36,-7.82,;5.68,-8.55,;5.47,-7.05,;7.08,-6.36,;7.08,-4.51,;7.64,-5.76,;10.08,-7.02,;10.91,-8.3,;11.75,-9.56,;13.23,-9.22,;14.27,-10.37,;13.78,-11.83,;12.28,-12.18,;11.24,-11.02,;14.83,-12.95,;16.33,-12.63,;17.37,-13.77,;16.92,-15.25,;15.39,-15.56,;14.38,-14.43,)| | ||
| Structure | 
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