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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Squalene synthase | ||
| Ligand | BDBM50052376 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_202113 (CHEMBL808971) | ||
| IC50 | 11±n/a nM | ||
| Citation |  Brown, GR; Clarke, DS; Foubister, AJ; Freeman, S; Harrison, PJ; Johnson, MC; Mallion, KB; McCormick, J; McTaggart, F; Reid, AC; Smith, GJ; Taylor, MJ Synthesis and activity of a novel series of 3-biarylquinuclidine squalene synthase inhibitors. J Med Chem39:2971-9 (1996) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Squalene synthase | |||
| Name: | Squalene synthase | ||
| Synonyms: | FDFT_RAT | FPP:FPP farnesyltransferase | Farnesyl-diphosphate farnesyltransferase | Fdft1 | SQS | SS | Squalene synthetase | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 48109.41 | ||
| Organism: | Rattus norvegicus | ||
| Description: | ChEMBL_1336736 | ||
| Residue: | 416 | ||
| Sequence: |
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| BDBM50052376 | |||
| n/a | |||
| Name | BDBM50052376 | ||
| Synonyms: | 3-Biphenyl-4-yl-1-aza-bicyclo[2.2.2]octane | CHEMBL319077 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C19H21N | ||
| Mol. Mass. | 263.3767 | ||
| SMILES | C1CN2CCC1C(C2)c1ccc(cc1)-c1ccccc1 |TLB:8:6:4.3:0.1,(10.23,-6.77,;10.66,-7.87,;10.41,-9.76,;8.89,-10.44,;8.69,-9.06,;10.15,-8.42,;11.5,-9.02,;11.79,-10.41,;13.04,-9.02,;13.81,-10.36,;15.35,-10.36,;16.12,-9.03,;15.35,-7.68,;13.81,-7.68,;17.66,-9.03,;18.43,-7.68,;19.97,-7.68,;20.74,-9.02,;19.97,-10.34,;18.43,-10.34,)| | ||
| Structure | 
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