Reaction Details |
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Target | Acetylcholinesterase |
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Ligand | BDBM20461 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2057657 (CHEMBL4712658) |
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IC50 | >200000±n/a nM |
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Citation | Viayna, E; Coquelle, N; Cieslikiewicz-Bouet, M; Cisternas, P; Oliva, CA; Sánchez-López, E; Ettcheto, M; Bartolini, M; De Simone, A; Ricchini, M; Rendina, M; Pons, M; Firuzi, O; Pérez, B; Saso, L; Andrisano, V; Nachon, F; Brazzolotto, X; García, ML; Camins, A; Silman, I; Jean, L; Inestrosa, NC; Colletier, JP; Renard, PY; Muñoz-Torrero, D Discovery of a Potent Dual Inhibitor of Acetylcholinesterase and Butyrylcholinesterase with Antioxidant Activity that Alleviates Alzheimer-like Pathology in Old APP/PS1 Mice. J Med Chem64:812-839 (2021) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Acetylcholinesterase |
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Name: | Acetylcholinesterase |
Synonyms: | ACES_HUMAN | ACHE | Acetylcholinesterase (AChE) | Acetylcholinesterase (human AChE) |
Type: | Enzyme |
Mol. Mass.: | 67792.70 |
Organism: | Homo sapiens (Human) |
Description: | P22303 |
Residue: | 614 |
Sequence: | MRPPQCLLHTPSLASPLLLLLLWLLGGGVGAEGREDAELLVTVRGGRLRGIRLKTPGGPV
SAFLGIPFAEPPMGPRRFLPPEPKQPWSGVVDATTFQSVCYQYVDTLYPGFEGTEMWNPN
RELSEDCLYLNVWTPYPRPTSPTPVLVWIYGGGFYSGASSLDVYDGRFLVQAERTVLVSM
NYRVGAFGFLALPGSREAPGNVGLLDQRLALQWVQENVAAFGGDPTSVTLFGESAGAASV
GMHLLSPPSRGLFHRAVLQSGAPNGPWATVGMGEARRRATQLAHLVGCPPGGTGGNDTEL
VACLRTRPAQVLVNHEWHVLPQESVFRFSFVPVVDGDFLSDTPEALINAGDFHGLQVLVG
VVKDEGSYFLVYGAPGFSKDNESLISRAEFLAGVRVGVPQVSDLAAEAVVLHYTDWLHPE
DPARLREALSDVVGDHNVVCPVAQLAGRLAAQGARVYAYVFEHRASTLSWPLWMGVPHGY
EIEFIFGIPLDPSRNYTAEEKIFAQRLMRYWANFARTGDPNEPRDPKAPQWPPYTAGAQQ
YVSLDLRPLEVRRGLRAQACAFWNRFLPKLLSATDTLDEAERQWKAEFHRWSSYMVHWKN
QFDHYSKQDRCSDL
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BDBM20461 |
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n/a |
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Name | BDBM20461 |
Synonyms: | (6E)-N-[(4-hydroxy-3-methoxyphenyl)methyl]-8-methylnon-6-enamide | (E)-N-[(4-hydroxy-3-methoxyphenyl)methyl]-8-methylnon-6-enamide | CAP | CHEMBL294199 | Capsaicin | Zostrix |
Type | n/a |
Emp. Form. | C18H27NO3 |
Mol. Mass. | 305.4119 |
SMILES | COc1cc(CNC(=O)CCCC\C=C\C(C)C)ccc1O |
Structure |
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