| Reaction Details |
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 | Report a problem with these data |
| Target | Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase |
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| Ligand | BDBM50579526 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2135455 (CHEMBL4845065) |
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| IC50 | >820±n/a nM |
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| Citation |  Turdi, H; Chao, H; Hangeland, JJ; Ahmad, S; Meng, W; Brigance, R; Zhao, G; Wang, W; Moore, F; Ye, XY; Mathur, A; Hou, X; Kempson, J; Wu, DR; Li, YX; Azzara, AV; Ma, Z; Chu, CH; Chen, L; Cullen, MJ; Rooney, S; Harvey, S; Kopcho, L; Panemangelor, R; Abell, L; O'Malley, K; Keim, WJ; Dierks, E; Chang, S; Foster, K; Apedo, A; Harden, D; Dabros, M; Gao, Q; Pelleymounter, MA; Whaley, JM; Robl, JA; Cheng, D; Lawrence, RM; Devasthale, P Screening Hit to Clinical Candidate: Discovery of BMS-963272, a Potent, Selective MGAT2 Inhibitor for the Treatment of Metabolic Disorders. J Med Chem64:14773-14792 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase |
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| Name: | Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase |
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| Synonyms: | GGNT3 | GNT-III | GlcNAc-T III | MGAT3 | MGAT3_HUMAN | N-acetylglucosaminyltransferase III | N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase III |
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| Type: | PROTEIN |
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| Mol. Mass.: | 61324.81 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_107586 |
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| Residue: | 533 |
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| Sequence: | MKMRRYKLFLMFCMAGLCLISFLHFFKTLSYVTFPRELASLSPNLVSSFFWNNAPVTPQA
SPEPGGPDLLRTPLYSHSPLLQPLPPSKAAEELHRVDLVLPEDTTEYFVRTKAGGVCFKP
GTKMLERPPPGRPEEKPEGANGSSARRPPRYLLSARERTGGRGARRKWVECVCLPGWHGP
SCGVPTVVQYSNLPTKERLVPREVPRRVINAINVNHEFDLLDVRFHELGDVVDAFVVCES
NFTAYGEPRPLKFREMLTNGTFEYIRHKVLYVFLDHFPPGGRQDGWIADDYLRTFLTQDG
VSRLRNLRPDDVFIIDDADEIPARDGVLFLKLYDGWTEPFAFHMRKSLYGFFWKQPGTLE
VVSGCTVDMLQAVYGLDGIRLRRRQYYTMPNFRQYENRTGHILVQWSLGSPLHFAGWHCS
WCFTPEGIYFKLVSAQNGDFPRWGDYEDKRDLNYIRGLIRTGGWFDGTQQEYPPADPSEH
MYAPKYLLKNYDRFHYLLDNPYQEPRSTAAGGWRHRGPEGRPPARGKLDEAEV
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| BDBM50579526 |
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| n/a |
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| Name | BDBM50579526 |
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| Synonyms: | CHEMBL4878564 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H25F6N5O2 |
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| Mol. Mass. | 553.4994 |
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| SMILES | Cc1ccc(cc1)C1=C(c2nnn[nH]2)C(=O)N[C@@](C1)(c1ccc(OCCCCCC(F)(F)F)cc1)C(F)(F)F |r,c:8| |
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| Structure | 
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