| Reaction Details |
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 | Report a problem with these data |
| Target | Acyl-CoA wax alcohol acyltransferase 2 |
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| Ligand | BDBM201239 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2135456 (CHEMBL4845066) |
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| IC50 | >33000±n/a nM |
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| Citation |  Turdi, H; Chao, H; Hangeland, JJ; Ahmad, S; Meng, W; Brigance, R; Zhao, G; Wang, W; Moore, F; Ye, XY; Mathur, A; Hou, X; Kempson, J; Wu, DR; Li, YX; Azzara, AV; Ma, Z; Chu, CH; Chen, L; Cullen, MJ; Rooney, S; Harvey, S; Kopcho, L; Panemangelor, R; Abell, L; O'Malley, K; Keim, WJ; Dierks, E; Chang, S; Foster, K; Apedo, A; Harden, D; Dabros, M; Gao, Q; Pelleymounter, MA; Whaley, JM; Robl, JA; Cheng, D; Lawrence, RM; Devasthale, P Screening Hit to Clinical Candidate: Discovery of BMS-963272, a Potent, Selective MGAT2 Inhibitor for the Treatment of Metabolic Disorders. J Med Chem64:14773-14792 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Acyl-CoA wax alcohol acyltransferase 2 |
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| Name: | Acyl-CoA wax alcohol acyltransferase 2 |
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| Synonyms: | ARAT | AWAT2 | AWAT2_HUMAN | Acyl-CoA retinol O-fatty-acyltransferase | DC4 | DGAT2L4 | Diacylglycerol O-acyltransferase 2-like protein 4 | Diacylglycerol O-acyltransferase candidate 4 | Long-chain-alcohol O-fatty-acyltransferase 2 | MFAT | Multifunctional O-acyltransferase | Retinol O-fatty-acyltransferase | WS | Wax synthase | hDC4 | hWS |
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| Type: | PROTEIN |
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| Mol. Mass.: | 38111.73 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_107584 |
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| Residue: | 333 |
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| Sequence: | MLLPSKKDLKTALDVFAVFQWSFSALLITTTVIAVNLYLVVFTPYWPVTVLILTWLAFDW
KTPQRGGRRFTCVRHWRLWKHYSDYFPLKLLKTHDICPSRNYILVCHPHGLFAHGWFGHF
ATEASGFSKIFPGITPYILTLGAFFWMPFLREYVMSTGACSVSRSSIDFLLTHKGTGNMV
IVVIGGLAECRYSLPGSSTLVLKNRSGFVRMALQHGVPLIPAYAFGETDLYDQHIFTPGG
FVNRFQKWFQSMVHIYPCAFYGRGFTKNSWGLLPYSRPVTTIVGEPLPMPKIENPSQEIV
AKYHTLYIDALRKLFDQHKTKFGISETQELEII
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| BDBM201239 |
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| n/a |
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| Name | BDBM201239 |
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| Synonyms: | US9187424, 6-2 |
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| Type | Small organic molecule |
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| Emp. Form. | C31H28F6N2O4 |
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| Mol. Mass. | 606.5554 |
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| SMILES | COc1ccc(NC(=O)C2=C(C[C@](NC2=O)(c2ccc(OCCCC(F)(F)F)cc2)C(F)(F)F)c2ccc(C)cc2)cc1 |r,t:9| |
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| Structure | 
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