| Reaction Details |
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 | Report a problem with these data |
| Target | Induced myeloid leukemia cell differentiation protein Mcl-1 |
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| Ligand | BDBM50508940 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2300376 |
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| Kd | 3540±n/a nM |
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| Citation |  Johannes, JW; Bates, S; Beigie, C; Belmonte, MA; Breen, J; Cao, S; Centrella, PA; Clark, MA; Cuozzo, JW; Dumelin, CE; Ferguson, AD; Habeshian, S; Hargreaves, D; Joubran, C; Kazmirski, S; Keefe, AD; Lamb, ML; Lan, H; Li, Y; Ma, H; Mlynarski, S; Packer, MJ; Rawlins, PB; Robbins, DW; Shen, H; Sigel, EA; Soutter, HH; Su, N; Troast, DM; Wang, H; Wickson, KF; Wu, C; Zhang, Y; Zhao, Q; Zheng, X; Hird, AW Structure Based Design of Non-Natural Peptidic Macrocyclic Mcl-1 Inhibitors. ACS Med Chem Lett8:239-244 (2017) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Induced myeloid leukemia cell differentiation protein Mcl-1 |
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| Name: | Induced myeloid leukemia cell differentiation protein Mcl-1 |
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| Synonyms: | BCL2L3 | Bcl-2-like protein 3 | Bcl-2-like protein 3 (Mcl-1) | Bcl-2-related protein EAT/mcl1 | Bcl2-L-3 | Induced myeloid leukemia cell differentiation protein (Mcl-1) | MCL1 | MCL1_HUMAN | Mcl-1 | Myeloid Cell factor-1 (Mcl-1) | Myeloid cell leukemia sequence 1 (BCL2-related) | mcl1/EAT |
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| Type: | Membrane; Single-pass membrane protein |
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| Mol. Mass.: | 37332.87 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q07820 |
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| Residue: | 350 |
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| Sequence: | MFGLKRNAVIGLNLYCGGAGLGAGSGGATRPGGRLLATEKEASARREIGGGEAGAVIGGS
AGASPPSTLTPDSRRVARPPPIGAEVPDVTATPARLLFFAPTRRAAPLEEMEAPAADAIM
SPEEELDGYEPEPLGKRPAVLPLLELVGESGNNTSTDGSLPSTPPPAEEEEDELYRQSLE
IISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNE
DDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVR
TKRDWLVKQRGWDGFVEFFHVEDLEGGIRNVLLAFAGVAGVGAGLAYLIR
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| BDBM50508940 |
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| n/a |
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| Name | BDBM50508940 |
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| Synonyms: | CHEMBL4582512 |
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| Type | Small organic molecule |
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| Emp. Form. | C37H42Cl3N5O4 |
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| Mol. Mass. | 727.119 |
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| SMILES | C[C@@H]1CCN(C)C(=O)C[C@@H](Cc2ccc(Cl)c(Cl)c2)NC(=O)CN2c3ccccc3CC[C@H](NC(=O)C[C@H](Cc3ccc(Cl)cc3)N1)C2=O |r| |
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| Structure | 
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