| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase PLK2 |
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| Ligand | BDBM50436721 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_971578 (CHEMBL2406852) |
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| IC50 | 60±n/a nM |
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| Citation |  Bowers, S; Truong, AP; Ye, M; Aubele, DL; Sealy, JM; Neitz, RJ; Hom, RK; Chan, W; Dappen, MS; Galemmo, RA; Konradi, AW; Sham, HL; Zhu, YL; Beroza, P; Tonn, G; Zhang, H; Hoffman, J; Motter, R; Fauss, D; Tanaka, P; Bova, MP; Ren, Z; Tam, D; Ruslim, L; Baker, J; Pandya, D; Diep, L; Fitzgerald, K; Artis, DR; Anderson, JP; Bergeron, M Design and synthesis of highly selective, orally active Polo-like kinase-2 (Plk-2) inhibitors. Bioorg Med Chem Lett23:2743-9 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein kinase PLK2 |
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| Name: | Serine/threonine-protein kinase PLK2 |
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| Synonyms: | PLK2 | PLK2_HUMAN | Polo-Like Kinase 2 | SNK | Serine/threonine-protein kinase PLK2 | Serine/threonine-protein kinase SNK | Serum-inducible kinase |
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| Type: | Serine/threonine-protein kinase |
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| Mol. Mass.: | 78259.87 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Full-length human PLK2 was expressed as GST-fusion protein using baculovirus expression system. GST-PLK2 was purified by using glutathione sepharose chromatography. |
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| Residue: | 685 |
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| Sequence: | MELLRTITYQPAASTKMCEQALGKGCGADSKKKRPPQPPEESQPPQSQAQVPPAAPHHHH
HHSHSGPEISRIIVDPTTGKRYCRGKVLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVAK
PHQREKIDKEIELHRILHHKHVVQFYHYFEDKENIYILLEYCSRRSMAHILKARKVLTEP
EVRYYLRQIVSGLKYLHEQEILHRDLKLGNFFINEAMELKVGDFGLAARLEPLEHRRRTI
CGTPNYLSPEVLNKQGHGCESDIWALGCVMYTMLLGRPPFETTNLKETYRCIREARYTMP
SSLLAPAKHLIASMLSKNPEDRPSLDDIIRHDFFLQGFTPDRLSSSCCHTVPDFHLSSPA
KNFFKKAAAALFGGKKDKARYIDTHNRVSKEDEDIYKLRHDLKKTSITQQPSKHRTDEEL
QPPTTTVARSGTPAVENKQQIGDAIRMIVRGTLGSCSSSSECLEDSTMGSVADTVARVLR
GCLENMPEADCIPKEQLSTSFQWVTKWVDYSNKYGFGYQLSDHTVGVLFNNGAHMSLLPD
KKTVHYYAELGQCSVFPATDAPEQFISQVTVLKYFSHYMEENLMDGGDLPSVTDIRRPRL
YLLQWLKSDKALMMLFNDGTFQVNFYHDHTKIIICSQNEEYLLTYINEDRISTTFRLTTL
LMSGCSSELKNRMEYALNMLLQRCN
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| BDBM50436721 |
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| n/a |
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| Name | BDBM50436721 |
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| Synonyms: | CHEMBL2401964 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H21N7OS |
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| Mol. Mass. | 383.471 |
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| SMILES | CC[C@H]1N(C(C)C)c2nc(ncc2N(C)C1=O)-c1c[nH]nc1-c1nccs1 |r| |
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| Structure | 
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