Reaction Details |
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Target | Sphingosine 1-phosphate receptor 1 |
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Ligand | BDBM50034564 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1439469 (CHEMBL3381246) |
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EC50 | 20±n/a nM |
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Citation | Skidmore, J; Heer, J; Johnson, CN; Norton, D; Redshaw, S; Sweeting, J; Hurst, D; Cridland, A; Vesey, D; Wall, I; Ahmed, M; Rivers, D; Myatt, J; Giblin, G; Philpott, K; Kumar, U; Stevens, A; Bit, RA; Haynes, A; Taylor, S; Watson, R; Witherington, J; Demont, E; Heightman, TD Optimization of sphingosine-1-phosphate-1 receptor agonists: effects of acidic, basic, and zwitterionic chemotypes on pharmacokinetic and pharmacodynamic profiles. J Med Chem57:10424-42 (2014) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Sphingosine 1-phosphate receptor 1 |
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Name: | Sphingosine 1-phosphate receptor 1 |
Synonyms: | CHEDG1 | EDG1 | Endothelial differentiation G-protein coupled receptor 1 | S1P receptor | S1P1 | S1PR1 | S1PR1_HUMAN | Sphingosine 1-phosphate receptor 1 (S1PR1) | Sphingosine 1-phosphate receptor Edg-1 |
Type: | Enzyme |
Mol. Mass.: | 42836.02 |
Organism: | Homo sapiens (Human) |
Description: | P21453 |
Residue: | 382 |
Sequence: | MGPTSVPLVKAHRSSVSDYVNYDIIVRHYNYTGKLNISADKENSIKLTSVVFILICCFII
LENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYTANLLLSGATTYKLTPAQWFLR
EGSMFVALSASVFSLLAIAIERYITMLKMKLHNGSNNFRLFLLISACWVISLILGGLPIM
GWNCISALSSCSTVLPLYHKHYILFCTTVFTLLLLSIVILYCRIYSLVRTRSRRLTFRKN
ISKASRSSEKSLALLKTVIIVLSVFIACWAPLFILLLLDVGCKVKTCDILFRAEYFLVLA
VLNSGTNPIIYTLTNKEMRRAFIRIMSCCKCPSGDSAGKFKRPIIAGMEFSRSKSDNSSH
PQKDEGDNPETIMSSGNVNSSS
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BDBM50034564 |
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n/a |
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Name | BDBM50034564 |
Synonyms: | CHEMBL3359848 |
Type | Small organic molecule |
Emp. Form. | C22H22ClN3O4 |
Mol. Mass. | 427.881 |
SMILES | CC(C)Oc1ccc(cc1Cl)-c1nc(no1)-c1cccc2C(CC(O)=O)NCCc12 |
Structure |
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