Ki Summary new BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetCytochrome P450 11B2 (CYP11B2)
LigandBDBM50092183
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1498857
IC50 0.600000±n/a nM
Citation Hoyt SBPark MKLondon CXiong YTata JBennett DJCooke ACai JCarswell ERobinson JMacLean JBrown LBelshaw SClarkson TRLiu KLiang GBStruthers MCully DWisniewski TRen NBopp CSok ACai TQStribling SPai LYMa XMetzger JVerras AMcMasters DChen QTung ETang WSalituro GBuist NKuethe JRivera NClemas JZhou GGibson JMaxwell CALassman MMcLaughlin TCastro-Perez JSzeto DForrest GHajdu RRosenbach MAli A Discovery of Benzimidazole CYP11B2 Inhibitors with in Vivo Activity in Rhesus Monkeys. ACS Med Chem Lett 6:573-8 (2015) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Cytochrome P450 11B2 (CYP11B2)
Name:Cytochrome P450 11B2
Synonyms:Aldosterone Synthase (CYP11B2) | Aldosterone synthase | Aldosterone-synthesizing enzyme | CYPXIB2 | Cytochrome P450 11B2 | Cytochrome P450 11B2, mitochondrial | P-450Aldo | P-450C18 | Steroid 18-hydroxylase
Type:Protein
Mol. Mass.:57582.15
Organism:Homo sapiens (Human)
Description:P19099
Residue:503
Sequence:
MALRAKAEVCVAAPWLSLQRARALGTRAARAPRTVLPFEAMPQHPGNRWLRLLQIWREQG
YEHLHLEMHQTFQELGPIFRYNLGGPRMVCVMLPEDVEKLQQVDSLHPCRMILEPWVAYR
QHRGHKCGVFLLNGPEWRFNRLRLNPDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQNA
RGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFM
PRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFNRPQHYTGIVAELLLKAELS
LEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKATT
ELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRP
ERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQED
IKMVYSFILRPGTSPLLTFRAIN
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50092183
n/a
NameBDBM50092183
Synonyms:CHEMBL3582471
TypeSmall organic molecule
Emp. Form.C16H11FN4
Mol. Mass.278.2837
SMILESFc1cc2nc(-c3cccnc3)n(C3CC3)c2cc1C#N
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: