Ki Summary

Reaction Details

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Target

Glucose-dependent insulinotropic receptor

Ligand

BDBM50106207

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_1506408 (CHEMBL3599704)

EC50

4.8±n/a nM

Citation

Han, S; Narayanan, S; Kim, SH; Calderon, I; Zhu, X; Kawasaki, A; Yue, D; Lehmann, J; Wong, A; Buzard, DJ; Semple, G; Carroll, C; Chu, ZL; Al-Sharmma, H; Shu, HH; Tung, SF; Unett, DJ; Behan, DP; Yoon, WH; Morgan, M; Usmani, KA; Chen, C; Sadeque, A; Leonard, JN; Jones, RM Discovery of a novel trans-1,4-dioxycyclohexane GPR119 agonist series. Bioorg Med Chem Lett25:3034-8 (2015) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Glucose-dependent insulinotropic receptor

Name:

Glucose-dependent insulinotropic receptor

Synonyms:

G-protein coupled receptor 119 (GPR119) | GP119_HUMAN | GPR119 | Glucose-dependent insulinotropic receptor

Type:

Protein

Mol. Mass.:

36901.49

Organism:

Homo sapiens (Human)

Description:

Q8TDV5

Residue:

335

Sequence:

MESSFSFGVILAVLASLIIATNTLVAVAVLLLIHKNDGVSLCFTLNLAVADTLIGVAISG
LLTDQLSSPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLAIKQPFRYLKIMSGF
VAGACIAGLWLVSYLIGFLPLGIPMFQQTAYKGQCSFFAVFHPHFVLTLSCVGFFPAMLL
FVFFYCDMLKIASMHSQQIRKMEHAGAMAGGYRSPRTPSDFKALRTVSVLIGSFALSWTP
FLITGIVQVACQECHLYLVLERYLWLLGVGNSLLNPLIYAYWQKEVRLQLYHMALGVKKV
LTSFLLFLSARNCGPERPRESSCHIVTISSSEFDG

BDBM50106207

n/a

Name

BDBM50106207

Synonyms:

CHEMBL3598100

Type

Small organic molecule

Emp. Form.

C20H28F3N3O6S

Mol. Mass.

495.513

SMILES

C[C@H](OC(=O)N1CCC(CC1)O[C@H]1CC[C@@H](CC1)Oc1cnc(cn1)S(C)(=O)=O)C(F)(F)F |r,wU:15.19,1.0,wD:12.12,(-2.36,10.63,;-1.3,10.01,;-1.31,8.47,;-2.65,7.7,;-3.71,8.33,;-2.65,6.16,;-3.99,5.4,;-4,3.86,;-2.66,3.08,;-1.33,3.85,;-1.32,5.39,;-2.67,1.54,;-1.33,.77,;-1.33,-.77,;,-1.54,;1.33,-.77,;1.33,.77,;,1.54,;2.67,-1.54,;4,-.77,;4,.77,;5.33,1.55,;6.67,.78,;6.67,-.76,;5.34,-1.53,;8,1.56,;9.06,2.18,;9.07,.95,;7.99,2.79,;.04,10.77,;.05,12.01,;1.1,10.15,;1.11,11.38,)|

Structure