Citation | Watterson, SH; De Lucca, GV; Shi, Q; Langevine, CM; Liu, Q; Batt, DG; Beaudoin Bertrand, M; Gong, H; Dai, J; Yip, S; Li, P; Sun, D; Wu, DR; Wang, C; Zhang, Y; Traeger, SC; Pattoli, MA; Skala, S; Cheng, L; Obermeier, MT; Vickery, R; Discenza, LN; D'Arienzo, CJ; Zhang, Y; Heimrich, E; Gillooly, KM; Taylor, TL; Pulicicchio, C; McIntyre, KW; Galella, MA; Tebben, AJ; Muckelbauer, JK; Chang, C; Rampulla, R; Mathur, A; Salter-Cid, L; Barrish, JC; Carter, PH; Fura, A; Burke, JR; Tino, JA Discovery of 6-Fluoro-5-(R)-(3-(S)-(8-fluoro-1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)-2-methylphenyl)-2-(S)-(2-hydroxypropan-2-yl)-2,3,4,9-tetrahydro-1H-carbazole-8-carboxamide (BMS-986142): A Reversible Inhibitor of Bruton's Tyrosine Kinase (BTK) Conformationally Constrained by Two Locke J Med Chem59:9173-9200 (2016) [PubMed] Article |
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SMILES | Cc1c(cccc1-n1c(=O)n(C)c2c(F)cccc2c1=O)-c1ccc(C(N)=O)c2[nH]c3C[C@H](CCc3c12)C(C)(C)O |r,wD:32.42,(74.94,-7.74,;73.61,-8.52,;72.28,-7.75,;70.95,-8.52,;70.95,-10.06,;72.28,-10.83,;73.62,-10.05,;74.95,-10.82,;74.95,-12.36,;73.62,-13.12,;76.28,-13.12,;76.28,-14.66,;77.61,-12.35,;78.94,-13.12,;78.94,-14.66,;80.27,-12.35,;80.27,-10.8,;78.93,-10.04,;77.61,-10.81,;76.27,-10.04,;76.27,-8.5,;72.28,-6.22,;73.62,-5.45,;73.61,-3.9,;72.28,-3.13,;72.27,-1.59,;73.61,-.82,;70.94,-.83,;70.95,-3.9,;69.48,-3.42,;68.58,-4.67,;67.04,-4.82,;66.4,-6.23,;67.31,-7.48,;68.85,-7.33,;69.48,-5.92,;70.95,-5.45,;64.9,-5.82,;63.81,-4.73,;65.3,-4.33,;63.81,-6.91,)| |