Found 403 hits of affinity data for UniProtKB/TrEMBL: P53582 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Methionine aminopeptidase 1
(Homo sapiens (Human)) | BDBM50375165
(CHEMBL271696)Show SMILES [#6]-[#7](-[#6])-c1ccc(\[#6]=[#6]\[#6]=[#6]-2\[#6](=O)-[#7]-[#6](=O)-[#7]-[#6]-2=O)cc1 Show InChI InChI=1S/C15H15N3O3/c1-18(2)11-8-6-10(7-9-11)4-3-5-12-13(19)16-15(21)17-14(12)20/h3-9H,1-2H3,(H2,16,17,19,20,21)/b4-3+ | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
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CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
North Dakota State University
Curated by ChEMBL
| Assay Description Inhibition of human methionine aminopeptidase 1 |
Bioorg Med Chem Lett 18: 2373-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.02.066 BindingDB Entry DOI: 10.7270/Q2348M7J |
More data for this Ligand-Target Pair | |
Methionine aminopeptidase 1
(Homo sapiens (Human)) | BDBM50375162
(CHEMBL257930)Show SMILES [#6]-[#7](-[#6])-c1ccc(\[#6]=[#6]\[#6]=[#6]-2\[#6](=O)-[#7]-[#6](=S)-[#7]-[#6]-2=O)cc1 Show InChI InChI=1S/C15H15N3O2S/c1-18(2)11-8-6-10(7-9-11)4-3-5-12-13(19)16-15(21)17-14(12)20/h3-9H,1-2H3,(H2,16,17,19,20,21)/b4-3+ | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
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CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
North Dakota State University
Curated by ChEMBL
| Assay Description Inhibition of human methionine aminopeptidase 1 |
Bioorg Med Chem Lett 18: 2373-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.02.066 BindingDB Entry DOI: 10.7270/Q2348M7J |
More data for this Ligand-Target Pair | |
Methionine aminopeptidase 1
(Homo sapiens (Human)) | BDBM50375169
(CHEMBL270813)Show SMILES Fc1ccc(\[#6]=[#6]-2\[#6](=O)-[#7]-[#6](=O)-[#7]-[#6]-2=O)cc1 Show InChI InChI=1S/C11H7FN2O3/c12-7-3-1-6(2-4-7)5-8-9(15)13-11(17)14-10(8)16/h1-5H,(H2,13,14,15,16,17) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
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CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
North Dakota State University
Curated by ChEMBL
| Assay Description Inhibition of human methionine aminopeptidase 1 |
Bioorg Med Chem Lett 18: 2373-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.02.066 BindingDB Entry DOI: 10.7270/Q2348M7J |
More data for this Ligand-Target Pair | |
Methionine aminopeptidase 1
(Homo sapiens (Human)) | BDBM50375171
(CHEMBL255586)Show SMILES [#8-]-[#7+](=O)-c1cccc(\[#6]=[#6]-2\[#6](=O)-[#7]-[#6](=O)-[#7]-[#6]-2=O)c1 Show InChI InChI=1S/C11H7N3O5/c15-9-8(10(16)13-11(17)12-9)5-6-2-1-3-7(4-6)14(18)19/h1-5H,(H2,12,13,15,16,17) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
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CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
North Dakota State University
Curated by ChEMBL
| Assay Description Inhibition of human methionine aminopeptidase 1 |
Bioorg Med Chem Lett 18: 2373-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.02.066 BindingDB Entry DOI: 10.7270/Q2348M7J |
More data for this Ligand-Target Pair | |
Methionine aminopeptidase 1
(Homo sapiens (Human)) | BDBM50375167
(CHEMBL270356)Show SMILES [#6]-[#8]-c1ccc(\[#6]=[#6]-2/[#6](=O)-[#7]-[#6](=O)-[#7]-[#6]-2=O)cc1 Show InChI InChI=1S/C12H10N2O4/c1-18-8-4-2-7(3-5-8)6-9-10(15)13-12(17)14-11(9)16/h2-6H,1H3,(H2,13,14,15,16,17) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
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Similars
| Article PubMed
| 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
North Dakota State University
Curated by ChEMBL
| Assay Description Inhibition of human methionine aminopeptidase 1 |
Bioorg Med Chem Lett 18: 2373-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.02.066 BindingDB Entry DOI: 10.7270/Q2348M7J |
More data for this Ligand-Target Pair | |
Methionine aminopeptidase 1
(Homo sapiens (Human)) | BDBM50078539
(CHEMBL3414950)Show InChI InChI=1S/C8H20NO3P/c1-3-5-7(6-4-2)8(9)13(10,11)12/h7-8H,3-6,9H2,1-2H3,(H2,10,11,12) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid PDB UniChem
Similars
| PDB Article PubMed
| 4.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
CSIR-Indian Institute of Chemical Technology
Curated by ChEMBL
| Assay Description Inhibition of Human MetAP1b using Met-pNA as substrate |
J Med Chem 58: 2350-7 (2015)
Article DOI: 10.1021/jm501790e BindingDB Entry DOI: 10.7270/Q2C53NJX |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Methionine aminopeptidase 1
(Homo sapiens (Human)) | BDBM50375170
(CHEMBL255143)Show SMILES [#8]-[#6](=O)-c1ccc(\[#6]=[#6]-2\[#6](=O)-[#7]-[#6](=O)-[#7]-[#6]-2=O)cc1 Show InChI InChI=1S/C12H8N2O5/c15-9-8(10(16)14-12(19)13-9)5-6-1-3-7(4-2-6)11(17)18/h1-5H,(H,17,18)(H2,13,14,15,16,19) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
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CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
North Dakota State University
Curated by ChEMBL
| Assay Description Inhibition of human methionine aminopeptidase 1 |
Bioorg Med Chem Lett 18: 2373-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.02.066 BindingDB Entry DOI: 10.7270/Q2348M7J |
More data for this Ligand-Target Pair | |
Methionine aminopeptidase 1
(Homo sapiens (Human)) | BDBM50375182
(CHEMBL270596)Show SMILES Fc1ccc(\[#6]=[#6]-2\[#6](=O)-[#7]-[#6](=S)-[#7]-[#6]-2=O)cc1 Show InChI InChI=1S/C11H7FN2O2S/c12-7-3-1-6(2-4-7)5-8-9(15)13-11(17)14-10(8)16/h1-5H,(H2,13,14,15,16,17) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 6.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
North Dakota State University
Curated by ChEMBL
| Assay Description Inhibition of human methionine aminopeptidase 1 |
Bioorg Med Chem Lett 18: 2373-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.02.066 BindingDB Entry DOI: 10.7270/Q2348M7J |
More data for this Ligand-Target Pair | |
Methionine aminopeptidase 1
(Homo sapiens (Human)) | BDBM50375172
(CHEMBL404480)Show SMILES [#8-]-[#7+](=O)-c1ccc(\[#6]=[#6]-2\[#6](=O)-[#7]-[#6](=O)-[#7]-[#6]-2=O)cc1 Show InChI InChI=1S/C11H7N3O5/c15-9-8(10(16)13-11(17)12-9)5-6-1-3-7(4-2-6)14(18)19/h1-5H,(H2,12,13,15,16,17) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
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CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 8.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
North Dakota State University
Curated by ChEMBL
| Assay Description Inhibition of human methionine aminopeptidase 1 |
Bioorg Med Chem Lett 18: 2373-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.02.066 BindingDB Entry DOI: 10.7270/Q2348M7J |
More data for this Ligand-Target Pair | |
Methionine aminopeptidase 1
(Homo sapiens (Human)) | BDBM50375166
(CHEMBL270142)Show SMILES O=[#6]-1-[#7]-[#6](=O)\[#6](=[#6]\[#6]=[#6]\c2ccccc2)-[#6](=O)-[#7]-1 Show InChI InChI=1S/C13H10N2O3/c16-11-10(12(17)15-13(18)14-11)8-4-7-9-5-2-1-3-6-9/h1-8H,(H2,14,15,16,17,18)/b7-4+ | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
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CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 9.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
North Dakota State University
Curated by ChEMBL
| Assay Description Inhibition of human methionine aminopeptidase 1 |
Bioorg Med Chem Lett 18: 2373-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.02.066 BindingDB Entry DOI: 10.7270/Q2348M7J |
More data for this Ligand-Target Pair | |
Methionine aminopeptidase 1
(Homo sapiens (Human)) | BDBM50337147
((RS)-1-amino-3-cyclohexylpropylphosphonic acid | C...)Show InChI InChI=1S/C9H20NO3P/c10-9(14(11,12)13)7-6-8-4-2-1-3-5-8/h8-9H,1-7,10H2,(H2,11,12,13) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 9.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
CSIR-Indian Institute of Chemical Technology
Curated by ChEMBL
| Assay Description Inhibition of Human MetAP1b using Met-pNA as substrate |
J Med Chem 58: 2350-7 (2015)
Article DOI: 10.1021/jm501790e BindingDB Entry DOI: 10.7270/Q2C53NJX |
More data for this Ligand-Target Pair | |
Methionine aminopeptidase 1
(Homo sapiens (Human)) | BDBM50237549
(5-(4-hydroxybenzylidene)pyrimidine-2,4,6(1H,3H,5H)...)Show SMILES [#8]-c1ccc(\[#6]=[#6]-2\[#6](=O)-[#7]-[#6](=O)-[#7]-[#6]-2=O)cc1 Show InChI InChI=1S/C11H8N2O4/c14-7-3-1-6(2-4-7)5-8-9(15)12-11(17)13-10(8)16/h1-5,14H,(H2,12,13,15,16,17) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
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Patents
Similars
| Article PubMed
| 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
North Dakota State University
Curated by ChEMBL
| Assay Description Inhibition of human methionine aminopeptidase 1 |
Bioorg Med Chem Lett 18: 2373-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.02.066 BindingDB Entry DOI: 10.7270/Q2348M7J |
More data for this Ligand-Target Pair | |
Methionine aminopeptidase 1
(Homo sapiens (Human)) | BDBM50375168
(CHEMBL258080)Show SMILES [#6]-[#7](-[#6])-c1ccc(\[#6]=[#6]-2/[#6](=O)-[#7]-[#6](=O)-[#7]-[#6]-2=O)cc1 Show InChI InChI=1S/C13H13N3O3/c1-16(2)9-5-3-8(4-6-9)7-10-11(17)14-13(19)15-12(10)18/h3-7H,1-2H3,(H2,14,15,17,18,19) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
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CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
North Dakota State University
Curated by ChEMBL
| Assay Description Inhibition of human methionine aminopeptidase 1 |
Bioorg Med Chem Lett 18: 2373-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.02.066 BindingDB Entry DOI: 10.7270/Q2348M7J |
More data for this Ligand-Target Pair | |
Methionine aminopeptidase 1
(Homo sapiens (Human)) | BDBM50137352
((S)-2-Amino-hexanoic acid hydroxy-[(2-pyridin-2-yl...)Show InChI InChI=1S/C15H24N4O3/c1-2-3-7-13(16)15(21)19(22)11-14(20)18-10-8-12-6-4-5-9-17-12/h4-6,9,13,22H,2-3,7-8,10-11,16H2,1H3,(H,18,20)/t13-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| PubMed
| 3.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The Ohio State University
Curated by ChEMBL
| Assay Description Inhibitory activity of the compound against Methionine aminopeptidase 1 |
Bioorg Med Chem Lett 14: 77-9 (2003)
BindingDB Entry DOI: 10.7270/Q2DV1J90 |
More data for this Ligand-Target Pair | |
Methionine aminopeptidase 1
(Homo sapiens (Human)) | BDBM50137355
((S)-2-Amino-N-hydroxy-4-methylsulfanyl-N-[(2-pyrid...)Show InChI InChI=1S/C14H22N4O3S/c1-22-9-6-12(15)14(20)18(21)10-13(19)17-8-5-11-4-2-3-7-16-11/h2-4,7,12,21H,5-6,8-10,15H2,1H3,(H,17,19)/t12-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| PubMed
| 4.80E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The Ohio State University
Curated by ChEMBL
| Assay Description Inhibitory activity of the compound against Methionine aminopeptidase 1 |
Bioorg Med Chem Lett 14: 77-9 (2003)
BindingDB Entry DOI: 10.7270/Q2DV1J90 |
More data for this Ligand-Target Pair | |
Methionine aminopeptidase 1
(Homo sapiens (Human)) | BDBM50078540
(CHEMBL1673077)Show InChI InChI=1S/C6H16NO3P/c1-3-4-5(2)6(7)11(8,9)10/h5-6H,3-4,7H2,1-2H3,(H2,8,9,10) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid PDB UniChem
Similars
| PDB Article PubMed
| 5.48E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
CSIR-Indian Institute of Chemical Technology
Curated by ChEMBL
| Assay Description Inhibition of Human MetAP1b using Met-pNA as substrate |
J Med Chem 58: 2350-7 (2015)
Article DOI: 10.1021/jm501790e BindingDB Entry DOI: 10.7270/Q2C53NJX |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Methionine aminopeptidase 1
(Homo sapiens (Human)) | BDBM50375163
(CHEMBL402646)Show SMILES O=[#6]1-[#7]-[#6](=S)-[#7]-[#6](=O)\[#6]-1=[#6]/[#6]=[#6]/c1ccccc1 Show InChI InChI=1S/C13H10N2O2S/c16-11-10(12(17)15-13(18)14-11)8-4-7-9-5-2-1-3-6-9/h1-8H,(H2,14,15,16,17,18)/b7-4+ | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
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CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 9.80E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
North Dakota State University
Curated by ChEMBL
| Assay Description Inhibition of human methionine aminopeptidase 1 |
Bioorg Med Chem Lett 18: 2373-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.02.066 BindingDB Entry DOI: 10.7270/Q2348M7J |
More data for this Ligand-Target Pair | |
Methionine aminopeptidase 1
(Homo sapiens (Human)) | BDBM50375177
(CHEMBL403366)Show SMILES [#6]-[#7]-1-[#6](=O)-[#7](-[#6])-[#6](=O)\[#6](=[#6]/c2ccc(F)cc2)-[#6]-1=O Show InChI InChI=1S/C13H11FN2O3/c1-15-11(17)10(12(18)16(2)13(15)19)7-8-3-5-9(14)6-4-8/h3-7H,1-2H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
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CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
North Dakota State University
Curated by ChEMBL
| Assay Description Inhibition of human methionine aminopeptidase 1 |
Bioorg Med Chem Lett 18: 2373-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.02.066 BindingDB Entry DOI: 10.7270/Q2348M7J |
More data for this Ligand-Target Pair | |
Methionine aminopeptidase 1
(Homo sapiens (Human)) | BDBM50237564
(5-(4-Hydroxybenzylidene)-2-thioxodihydropyrimidine...)Show SMILES [#8]-c1ccc(\[#6]=[#6]-2\[#6](=O)-[#7]-[#6](=S)-[#7]-[#6]-2=O)cc1 Show InChI InChI=1S/C11H8N2O3S/c14-7-3-1-6(2-4-7)5-8-9(15)12-11(17)13-10(8)16/h1-5,14H,(H2,12,13,15,16,17) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
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CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
North Dakota State University
Curated by ChEMBL
| Assay Description Inhibition of human methionine aminopeptidase 1 |
Bioorg Med Chem Lett 18: 2373-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.02.066 BindingDB Entry DOI: 10.7270/Q2348M7J |
More data for this Ligand-Target Pair | |
Methionine aminopeptidase 1
(Homo sapiens (Human)) | BDBM50375187
(CHEMBL403400)Show SMILES [#6]-[#7]-1-[#6](=O)-[#7](-[#6])-[#6](=O)\[#6](=[#6]/c2ccccc2)-[#6]-1=O Show InChI InChI=1S/C13H12N2O3/c1-14-11(16)10(12(17)15(2)13(14)18)8-9-6-4-3-5-7-9/h3-8H,1-2H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
North Dakota State University
Curated by ChEMBL
| Assay Description Inhibition of human methionine aminopeptidase 1 |
Bioorg Med Chem Lett 18: 2373-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.02.066 BindingDB Entry DOI: 10.7270/Q2348M7J |
More data for this Ligand-Target Pair | |
Methionine aminopeptidase 1
(Homo sapiens (Human)) | BDBM50375186
(CHEMBL273177)Show SMILES [#6]-[#7]-1-[#6](=O)-[#7](-[#6])-[#6](=O)\[#6](=[#6]/c2ccc(-[#8])cc2)-[#6]-1=O Show InChI InChI=1S/C13H12N2O4/c1-14-11(17)10(12(18)15(2)13(14)19)7-8-3-5-9(16)6-4-8/h3-7,16H,1-2H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
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CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
North Dakota State University
Curated by ChEMBL
| Assay Description Inhibition of human methionine aminopeptidase 1 |
Bioorg Med Chem Lett 18: 2373-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.02.066 BindingDB Entry DOI: 10.7270/Q2348M7J |
More data for this Ligand-Target Pair | |
Methionine aminopeptidase 1
(Homo sapiens (Human)) | BDBM50375185
(CHEMBL256878)Show SMILES [#6]-[#8]-c1ccc(\[#6]=[#6]-2\[#6](=O)-[#7](-[#6])-[#6](=O)-[#7](-[#6])-[#6]-2=O)cc1 Show InChI InChI=1S/C14H14N2O4/c1-15-12(17)11(13(18)16(2)14(15)19)8-9-4-6-10(20-3)7-5-9/h4-8H,1-3H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
North Dakota State University
Curated by ChEMBL
| Assay Description Inhibition of human methionine aminopeptidase 1 |
Bioorg Med Chem Lett 18: 2373-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.02.066 BindingDB Entry DOI: 10.7270/Q2348M7J |
More data for this Ligand-Target Pair | |
Methionine aminopeptidase 1
(Homo sapiens (Human)) | BDBM50375184
(CHEMBL408043)Show SMILES [#8-]-[#7+](=O)-c1cccc(\[#6]=[#6]-2\[#6](=O)-[#7]-[#6](=S)-[#7]-[#6]-2=O)c1 Show InChI InChI=1S/C11H7N3O4S/c15-9-8(10(16)13-11(19)12-9)5-6-2-1-3-7(4-6)14(17)18/h1-5H,(H2,12,13,15,16,19) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
North Dakota State University
Curated by ChEMBL
| Assay Description Inhibition of human methionine aminopeptidase 1 |
Bioorg Med Chem Lett 18: 2373-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.02.066 BindingDB Entry DOI: 10.7270/Q2348M7J |
More data for this Ligand-Target Pair | |
Methionine aminopeptidase 1
(Homo sapiens (Human)) | BDBM50375173
(CHEMBL256700)Show SMILES O=[#6]1-[#7]-[#6](=S)-[#7]-[#6](=O)\[#6]-1=[#6]\c1ccccc1 Show InChI InChI=1S/C11H8N2O2S/c14-9-8(10(15)13-11(16)12-9)6-7-4-2-1-3-5-7/h1-6H,(H2,12,13,14,15,16) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
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| Article PubMed
| >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
North Dakota State University
Curated by ChEMBL
| Assay Description Inhibition of human methionine aminopeptidase 1 |
Bioorg Med Chem Lett 18: 2373-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.02.066 BindingDB Entry DOI: 10.7270/Q2348M7J |
More data for this Ligand-Target Pair | |
Methionine aminopeptidase 1
(Homo sapiens (Human)) | BDBM50375174
(CHEMBL258079)Show SMILES [#6]-[#7](-[#6])-c1ccc(\[#6]=[#6]\[#6]=[#6]-2\[#6](=O)-[#7](-[#6])-[#6](=O)-[#7](-[#6])-[#6]-2=O)cc1 Show InChI InChI=1S/C17H19N3O3/c1-18(2)13-10-8-12(9-11-13)6-5-7-14-15(21)19(3)17(23)20(4)16(14)22/h5-11H,1-4H3/b6-5+ | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
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| Article PubMed
| >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
North Dakota State University
Curated by ChEMBL
| Assay Description Inhibition of human methionine aminopeptidase 1 |
Bioorg Med Chem Lett 18: 2373-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.02.066 BindingDB Entry DOI: 10.7270/Q2348M7J |
More data for this Ligand-Target Pair | |
Methionine aminopeptidase 1
(Homo sapiens (Human)) | BDBM50375175
(CHEMBL256879)Show SMILES [#6]-[#7]-1-[#6](=O)-[#7](-[#6])-[#6](=O)\[#6](=[#6]/[#6]=[#6]/c2ccccc2)-[#6]-1=O Show InChI InChI=1S/C15H14N2O3/c1-16-13(18)12(14(19)17(2)15(16)20)10-6-9-11-7-4-3-5-8-11/h3-10H,1-2H3/b9-6+ | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
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CHEMBL PC cid PC sid UniChem
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| Article PubMed
| >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
North Dakota State University
Curated by ChEMBL
| Assay Description Inhibition of human methionine aminopeptidase 1 |
Bioorg Med Chem Lett 18: 2373-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.02.066 BindingDB Entry DOI: 10.7270/Q2348M7J |
More data for this Ligand-Target Pair | |
Methionine aminopeptidase 1
(Homo sapiens (Human)) | BDBM50375176
(CHEMBL404233)Show SMILES [#6]-[#7](-[#6])-c1ccc(\[#6]=[#6]-2\[#6](=O)-[#7](-[#6])-[#6](=O)-[#7](-[#6])-[#6]-2=O)cc1 Show InChI InChI=1S/C15H17N3O3/c1-16(2)11-7-5-10(6-8-11)9-12-13(19)17(3)15(21)18(4)14(12)20/h5-9H,1-4H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
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| Article PubMed
| >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
North Dakota State University
Curated by ChEMBL
| Assay Description Inhibition of human methionine aminopeptidase 1 |
Bioorg Med Chem Lett 18: 2373-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.02.066 BindingDB Entry DOI: 10.7270/Q2348M7J |
More data for this Ligand-Target Pair | |
Methionine aminopeptidase 1
(Homo sapiens (Human)) | BDBM50375164
(CHEMBL269821)Show SMILES [#6]-[#7](-[#6])-c1ccc(\[#6]=[#6]-2/[#6](=O)-[#7]-[#6](=S)-[#7]-[#6]-2=O)cc1 Show InChI InChI=1S/C13H13N3O2S/c1-16(2)9-5-3-8(4-6-9)7-10-11(17)14-13(19)15-12(10)18/h3-7H,1-2H3,(H2,14,15,17,18,19) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
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CHEMBL PC cid PC sid UniChem
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| Article PubMed
| >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
North Dakota State University
Curated by ChEMBL
| Assay Description Inhibition of human methionine aminopeptidase 1 |
Bioorg Med Chem Lett 18: 2373-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.02.066 BindingDB Entry DOI: 10.7270/Q2348M7J |
More data for this Ligand-Target Pair | |
Methionine aminopeptidase 1
(Homo sapiens (Human)) | BDBM50375178
(CHEMBL404693)Show SMILES [#6]-[#7]-1-[#6](=O)-[#7](-[#6])-[#6](=O)\[#6](=[#6]/c2ccc(cc2)-[#6](-[#8])=O)-[#6]-1=O Show InChI InChI=1S/C14H12N2O5/c1-15-11(17)10(12(18)16(2)14(15)21)7-8-3-5-9(6-4-8)13(19)20/h3-7H,1-2H3,(H,19,20) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
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CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
North Dakota State University
Curated by ChEMBL
| Assay Description Inhibition of human methionine aminopeptidase 1 |
Bioorg Med Chem Lett 18: 2373-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.02.066 BindingDB Entry DOI: 10.7270/Q2348M7J |
More data for this Ligand-Target Pair | |
Methionine aminopeptidase 1
(Homo sapiens (Human)) | BDBM50375179
(CHEMBL257927)Show SMILES [#6]-[#7]-1-[#6](=O)-[#7](-[#6])-[#6](=O)\[#6](=[#6]/c2cccc(c2)-[#7+](-[#8-])=O)-[#6]-1=O Show InChI InChI=1S/C13H11N3O5/c1-14-11(17)10(12(18)15(2)13(14)19)7-8-4-3-5-9(6-8)16(20)21/h3-7H,1-2H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
North Dakota State University
Curated by ChEMBL
| Assay Description Inhibition of human methionine aminopeptidase 1 |
Bioorg Med Chem Lett 18: 2373-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.02.066 BindingDB Entry DOI: 10.7270/Q2348M7J |
More data for this Ligand-Target Pair | |
Methionine aminopeptidase 1
(Homo sapiens (Human)) | BDBM50375180
(CHEMBL256269)Show SMILES [#6]-[#7]-1-[#6](=O)-[#7](-[#6])-[#6](=O)\[#6](=[#6]/c2ccc(cc2)-[#7+](-[#8-])=O)-[#6]-1=O Show InChI InChI=1S/C13H11N3O5/c1-14-11(17)10(12(18)15(2)13(14)19)7-8-3-5-9(6-4-8)16(20)21/h3-7H,1-2H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
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CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
North Dakota State University
Curated by ChEMBL
| Assay Description Inhibition of human methionine aminopeptidase 1 |
Bioorg Med Chem Lett 18: 2373-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.02.066 BindingDB Entry DOI: 10.7270/Q2348M7J |
More data for this Ligand-Target Pair | |
Methionine aminopeptidase 1
(Homo sapiens (Human)) | BDBM50375181
(CHEMBL271859)Show SMILES [#6]-[#8]-c1ccc(\[#6]=[#6]-2/[#6](=O)-[#7]-[#6](=S)-[#7]-[#6]-2=O)cc1 Show InChI InChI=1S/C12H10N2O3S/c1-17-8-4-2-7(3-5-8)6-9-10(15)13-12(18)14-11(9)16/h2-6H,1H3,(H2,13,14,15,16,18) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
North Dakota State University
Curated by ChEMBL
| Assay Description Inhibition of human methionine aminopeptidase 1 |
Bioorg Med Chem Lett 18: 2373-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.02.066 BindingDB Entry DOI: 10.7270/Q2348M7J |
More data for this Ligand-Target Pair | |
Methionine aminopeptidase 1
(Homo sapiens (Human)) | BDBM50375188
(CHEMBL408042)Show SMILES [#8-]-[#7+](=O)-c1ccc(\[#6]=[#6]-2\[#6](=O)-[#7]-[#6](=S)-[#7]-[#6]-2=O)cc1 Show InChI InChI=1S/C11H7N3O4S/c15-9-8(10(16)13-11(19)12-9)5-6-1-3-7(4-2-6)14(17)18/h1-5H,(H2,12,13,15,16,19) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
North Dakota State University
Curated by ChEMBL
| Assay Description Inhibition of human methionine aminopeptidase 1 |
Bioorg Med Chem Lett 18: 2373-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.02.066 BindingDB Entry DOI: 10.7270/Q2348M7J |
More data for this Ligand-Target Pair | |
Methionine aminopeptidase 1
(Homo sapiens (Human)) | BDBM50375183
(CHEMBL439416)Show SMILES [#8]-[#6](=O)-c1ccc(\[#6]=[#6]-2\[#6](=O)-[#7]-[#6](=S)-[#7]-[#6]-2=O)cc1 Show InChI InChI=1S/C12H8N2O4S/c15-9-8(10(16)14-12(19)13-9)5-6-1-3-7(4-2-6)11(17)18/h1-5H,(H,17,18)(H2,13,14,15,16,19) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
North Dakota State University
Curated by ChEMBL
| Assay Description Inhibition of human methionine aminopeptidase 1 |
Bioorg Med Chem Lett 18: 2373-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.02.066 BindingDB Entry DOI: 10.7270/Q2348M7J |
More data for this Ligand-Target Pair | |
Methionine aminopeptidase 1
(Homo sapiens (Human)) | BDBM50316031
(CHEMBL1090366 | amino(phenyl)methylphosphonic acid)Show InChI InChI=1S/C7H10NO3P/c8-7(12(9,10)11)6-4-2-1-3-5-6/h1-5,7H,8H2,(H2,9,10,11) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
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Patents
Similars
| PDB Article PubMed
| 1.12E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
CSIR-Indian Institute of Chemical Technology
Curated by ChEMBL
| Assay Description Inhibition of Human MetAP1b using Met-pNA as substrate |
J Med Chem 58: 2350-7 (2015)
Article DOI: 10.1021/jm501790e BindingDB Entry DOI: 10.7270/Q2C53NJX |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Methionine aminopeptidase 1
(Homo sapiens (Human)) | BDBM50375161
(CHEMBL272757)Show SMILES O=[#6]-1-[#7]-[#6](=O)\[#6](=[#6]/c2ccccc2)-[#6](=O)-[#7]-1 Show InChI InChI=1S/C11H8N2O3/c14-9-8(10(15)13-11(16)12-9)6-7-4-2-1-3-5-7/h1-6H,(H2,12,13,14,15,16) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
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CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 1.62E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
North Dakota State University
Curated by ChEMBL
| Assay Description Inhibition of human methionine aminopeptidase 1 |
Bioorg Med Chem Lett 18: 2373-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.02.066 BindingDB Entry DOI: 10.7270/Q2348M7J |
More data for this Ligand-Target Pair | |
Methionine aminopeptidase 1
(Homo sapiens (Human)) | BDBM50137354
(CHEMBL164406 | [((R)-2-Amino-propionyl)-hydroxy-am...)Show InChI InChI=1S/C5H10N2O4/c1-3(6)5(10)7(11)2-4(8)9/h3,11H,2,6H2,1H3,(H,8,9)/t3-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| PubMed
| 1.80E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The Ohio State University
Curated by ChEMBL
| Assay Description Inhibitory activity of the compound against Methionine aminopeptidase 1 |
Bioorg Med Chem Lett 14: 77-9 (2003)
BindingDB Entry DOI: 10.7270/Q2DV1J90 |
More data for this Ligand-Target Pair | |
Methionine aminopeptidase 1
(Homo sapiens (Human)) | BDBM50137353
(CHEMBL349154 | [((S)-2-Amino-4-methylsulfanyl-buty...)Show InChI InChI=1S/C7H14N2O4S/c1-14-3-2-5(8)7(12)9(13)4-6(10)11/h5,13H,2-4,8H2,1H3,(H,10,11)/t5-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| PubMed
| 3.90E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The Ohio State University
Curated by ChEMBL
| Assay Description Inhibitory activity of the compound against Methionine aminopeptidase 1 |
Bioorg Med Chem Lett 14: 77-9 (2003)
BindingDB Entry DOI: 10.7270/Q2DV1J90 |
More data for this Ligand-Target Pair | |
Methionine aminopeptidase 1
(Homo sapiens (Human)) | BDBM50337150
((RS)-1-amino-2-cyclohexylethylphosphonic acid | CH...)Show InChI InChI=1S/C8H18NO3P/c9-8(13(10,11)12)6-7-4-2-1-3-5-7/h7-8H,1-6,9H2,(H2,10,11,12) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid PDB UniChem
Similars
| PDB Article PubMed
| >5.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
CSIR-Indian Institute of Chemical Technology
Curated by ChEMBL
| Assay Description Inhibition of Human MetAP1b using Met-pNA as substrate |
J Med Chem 58: 2350-7 (2015)
Article DOI: 10.1021/jm501790e BindingDB Entry DOI: 10.7270/Q2C53NJX |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Methionine aminopeptidase 1
(Homo sapiens (Human)) | BDBM50078541
(CHEMBL3414949)Show InChI InChI=1S/C7H16NO3P/c8-7(12(9,10)11)6-4-2-1-3-5-6/h6-7H,1-5,8H2,(H2,9,10,11) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid PDB UniChem
Similars
| PDB Article PubMed
| >5.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
CSIR-Indian Institute of Chemical Technology
Curated by ChEMBL
| Assay Description Inhibition of Human MetAP1b using Met-pNA as substrate |
J Med Chem 58: 2350-7 (2015)
Article DOI: 10.1021/jm501790e BindingDB Entry DOI: 10.7270/Q2C53NJX |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Methionine aminopeptidase 1
(Homo sapiens (Human)) | BDBM50267199
(CHEMBL4079583)Show SMILES COc1ccc(cc1)N1CCN(CC1)c1nc(nc2ccccc12)-c1ccccn1 Show InChI InChI=1S/C24H23N5O/c1-30-19-11-9-18(10-12-19)28-14-16-29(17-15-28)24-20-6-2-3-7-21(20)26-23(27-24)22-8-4-5-13-25-22/h2-13H,14-17H2,1H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid PDB UniChem
Similars
| PDB Article PubMed
| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
Colorado Mesa University
Curated by ChEMBL
| Assay Description Inhibition of human MetAP1 |
J Nat Prod 80: 740-755 (2017)
Article DOI: 10.1021/acs.jnatprod.6b00970 BindingDB Entry DOI: 10.7270/Q2SN0CG4 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Methionine aminopeptidase 1
(Homo sapiens (Human)) | BDBM50435227
(CHEMBL2392772)Show SMILES Cc1nc(nc(NC2CCN(CC2)c2ncc(cc2Cl)C(F)(F)F)c1Cl)-c1ccccn1 Show InChI InChI=1S/C21H19Cl2F3N6/c1-12-17(23)19(31-18(29-12)16-4-2-3-7-27-16)30-14-5-8-32(9-6-14)20-15(22)10-13(11-28-20)21(24,25)26/h2-4,7,10-11,14H,5-6,8-9H2,1H3,(H,29,30,31) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
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CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 360 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description Inhibition of human recombinant full-length cytosolic METAP1 expressed in Escherichia coli BL21(DE3) using Met-Pro-p-nitroanilide as substrate after ... |
Bioorg Med Chem 21: 2600-17 (2013)
Article DOI: 10.1016/j.bmc.2013.02.023 BindingDB Entry DOI: 10.7270/Q290256X |
More data for this Ligand-Target Pair | |
Methionine aminopeptidase 1
(Homo sapiens (Human)) | BDBM17589
((2S,3R)-3-amino-5-(ethylsulfanyl)-2-hydroxy-N-[(1S...)Show SMILES CCSCC[C@@H](N)[C@H](O)C(=O)N[C@@H](C)c1cccc2ccccc12 |r| Show InChI InChI=1S/C19H26N2O2S/c1-3-24-12-11-17(20)18(22)19(23)21-13(2)15-10-6-8-14-7-4-5-9-16(14)15/h4-10,13,17-18,22H,3,11-12,20H2,1-2H3,(H,21,23)/t13-,17+,18-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL MMDB PC cid PC sid PDB UniChem
Similars
| Article PubMed
| n/a | n/a | 370 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Inhibitory activity against human methionine aminopeptidase-1 |
Bioorg Med Chem Lett 14: 865-8 (2004)
Article DOI: 10.1016/j.bmcl.2003.12.031 BindingDB Entry DOI: 10.7270/Q2Z31Z3N |
More data for this Ligand-Target Pair | |
Methionine aminopeptidase 1
(Homo sapiens (Human)) | BDBM17589
((2S,3R)-3-amino-5-(ethylsulfanyl)-2-hydroxy-N-[(1S...)Show SMILES CCSCC[C@@H](N)[C@H](O)C(=O)N[C@@H](C)c1cccc2ccccc12 |r| Show InChI InChI=1S/C19H26N2O2S/c1-3-24-12-11-17(20)18(22)19(23)21-13(2)15-10-6-8-14-7-4-5-9-16(14)15/h4-10,13,17-18,22H,3,11-12,20H2,1-2H3,(H,21,23)/t13-,17+,18-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL MMDB PC cid PC sid PDB UniChem
Similars
| PubMed
| n/a | n/a | 370 | n/a | n/a | n/a | n/a | 7.4 | 22 |
Abbott Laboratories
| Assay Description A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase activity by monitoring the production of free methionine with L... |
Cancer Res 63: 7861-9 (2003)
BindingDB Entry DOI: 10.7270/Q2Z31WXK |
More data for this Ligand-Target Pair | |
Methionine aminopeptidase 1
(Homo sapiens (Human)) | BDBM17847
(CHEMBL327579 | pyridine-2-carboxylic acid inhibito...)Show InChI InChI=1S/C14H16N4O3S/c1-14(2,3)21-13(20)17-9-5-4-6-15-10(9)11(19)18-12-16-7-8-22-12/h4-8H,1-3H3,(H,17,20)(H,16,18,19) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem
Patents
Similars
| DrugBank MMDB PDB Article PubMed
| n/a | n/a | 400 | n/a | n/a | n/a | n/a | n/a | n/a |
Colorado Mesa University
Curated by ChEMBL
| Assay Description Inhibition of human MetAP1 |
J Nat Prod 80: 740-755 (2017)
Article DOI: 10.1021/acs.jnatprod.6b00970 BindingDB Entry DOI: 10.7270/Q2SN0CG4 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Methionine aminopeptidase 1
(Homo sapiens (Human)) | BDBM50435217
(CHEMBL2392900)Show SMILES Cc1nc(nc(NC[C@H](NS(=O)(=O)CCN2CCN(CCO)CC2)c2ccccc2)c1Cl)-c1ccccn1 |r| Show InChI InChI=1S/C26H34ClN7O3S/c1-20-24(27)26(31-25(30-20)22-9-5-6-10-28-22)29-19-23(21-7-3-2-4-8-21)32-38(36,37)18-16-34-13-11-33(12-14-34)15-17-35/h2-10,23,32,35H,11-19H2,1H3,(H,29,30,31)/t23-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 600 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description Inhibition of human recombinant full-length cytosolic METAP1 expressed in Escherichia coli BL21(DE3) using Met-Pro-p-nitroanilide as substrate after ... |
Bioorg Med Chem 21: 2600-17 (2013)
Article DOI: 10.1016/j.bmc.2013.02.023 BindingDB Entry DOI: 10.7270/Q290256X |
More data for this Ligand-Target Pair | |
Methionine aminopeptidase 1
(Homo sapiens (Human)) | BDBM50435224
(CHEMBL2392893)Show SMILES Cc1nc(nc(NC[C@H](NC(=O)CCN2CCNCC2)c2ccccc2)c1Cl)-c1ccccn1 |r| Show InChI InChI=1S/C25H30ClN7O/c1-18-23(26)25(32-24(30-18)20-9-5-6-11-28-20)29-17-21(19-7-3-2-4-8-19)31-22(34)10-14-33-15-12-27-13-16-33/h2-9,11,21,27H,10,12-17H2,1H3,(H,31,34)(H,29,30,32)/t21-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 600 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description Inhibition of human recombinant full-length cytosolic METAP1 expressed in Escherichia coli BL21(DE3) using Met-Pro-p-nitroanilide as substrate after ... |
Bioorg Med Chem 21: 2600-17 (2013)
Article DOI: 10.1016/j.bmc.2013.02.023 BindingDB Entry DOI: 10.7270/Q290256X |
More data for this Ligand-Target Pair | |
Methionine aminopeptidase 1
(Homo sapiens (Human)) | BDBM50295174
(Bengamide A | CHEMBL256279)Show SMILES CCCCCCCCCCCCCC(=O)O[C@H]1CC[C@H](NC(=O)[C@H](OC)[C@H](O)[C@@H](O)[C@H](O)\C=C\C(C)C)C(=O)NC1 |r| Show InChI InChI=1S/C31H56N2O8/c1-5-6-7-8-9-10-11-12-13-14-15-16-26(35)41-23-18-19-24(30(38)32-21-23)33-31(39)29(40-4)28(37)27(36)25(34)20-17-22(2)3/h17,20,22-25,27-29,34,36-37H,5-16,18-19,21H2,1-4H3,(H,32,38)(H,33,39)/b20-17+/t23-,24-,25+,27-,28+,29+/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 700 | n/a | n/a | n/a | n/a | n/a | n/a |
Colorado Mesa University
Curated by ChEMBL
| Assay Description Inhibition of human MetAP1 |
J Nat Prod 80: 740-755 (2017)
Article DOI: 10.1021/acs.jnatprod.6b00970 BindingDB Entry DOI: 10.7270/Q2SN0CG4 |
More data for this Ligand-Target Pair | |
Methionine aminopeptidase 1
(Homo sapiens (Human)) | BDBM50433375
(CHEMBL472879 | GNF-Pf-359)Show InChI InChI=1S/C18H17ClN4/c1-13-16(19)18(21-12-10-14-7-3-2-4-8-14)23-17(22-13)15-9-5-6-11-20-15/h2-9,11H,10,12H2,1H3,(H,21,22,23) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem
Similars
| DrugBank MMDB PDB Article PubMed
| n/a | n/a | 700 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01721 BindingDB Entry DOI: 10.7270/Q2BG2SZC |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Methionine aminopeptidase 1
(Homo sapiens (Human)) | BDBM50267193
(CHEMBL4078211)Show SMILES CO[C@H]([C@H](O)[C@@H](O)[C@H](O)\C=C\C(C)(C)C)C(=O)N[C@H]1CC[C@H](CNC1=O)OC(=O)C1CCCCC1 |r| Show InChI InChI=1S/C25H42N2O8/c1-25(2,3)13-12-18(28)19(29)20(30)21(34-4)23(32)27-17-11-10-16(14-26-22(17)31)35-24(33)15-8-6-5-7-9-15/h12-13,15-21,28-30H,5-11,14H2,1-4H3,(H,26,31)(H,27,32)/b13-12+/t16-,17+,18-,19+,20-,21-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 700 | n/a | n/a | n/a | n/a | n/a | n/a |
Colorado Mesa University
Curated by ChEMBL
| Assay Description Inhibition of human MetAP1 |
J Nat Prod 80: 740-755 (2017)
Article DOI: 10.1021/acs.jnatprod.6b00970 BindingDB Entry DOI: 10.7270/Q2SN0CG4 |
More data for this Ligand-Target Pair | |