78 articles for thisTarget

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The following articles (labelled with PubMed ID or TBD) are for your review

PMID	Data	Article Title	Organization
27050842	39	Potent and Selective Human Neuronal Nitric Oxide Synthase Inhibition by Optimization of the 2-Aminopyridine-Based Scaffold with a Pyridine Linker.	Northwestern University
23458846	16	Target- and mechanism-based therapeutics for neurodegenerative diseases: strength in numbers.	Northwestern University
21684157	68	Novel nanomolar imidazo[4,5-b]pyridines as selective nitric oxide synthase (iNOS) inhibitors: SAR and structural insights.	Nycomed
22840695	52	Discovery of a potent, orally bioavailable and highly selective human neuronal nitric oxide synthase (nNOS) inhibitor, N-(1-(piperidin-4-yl)indolin-5-yl)thiophene-2-carboximidamide as a pre-clinical development candidate for the treatment of migraine.	Neuraxon
22335555	43	1,2,3,4-tetrahydroquinoline-based selective human neuronal nitric oxide synthase (nNOS) inhibitors: lead optimization studies resulting in the identification of N-(1-(2-(methylamino)ethyl)-1,2,3,4-tetrahydroquinolin-6-yl)thiophene-2-carboximidamide as a preclinical development candidate.	Neuraxon
23123728	4	Synthesis, biological evaluation and molecular docking studies of 3-(triazolyl)-coumarin derivatives: effect on inducible nitric oxide synthase.	Universidade De S£O Paulo
24900459	53	NOpiates: Novel Dual Action Neuronal Nitric Oxide Synthase Inhibitors with µ-Opioid Agonist Activity.	TBA
22420844	86	First-in-class, dual-action, 3,5-disubstituted indole derivatives having human nitric oxide synthase (nNOS) and norepinephrine reuptake inhibitory (NERI) activity for the treatment of neuropathic pain.	Neuraxon
22370270	30	Novel, druglike 1,7-disubstituted 2,3,4,5-tetrahydro-1H-benzo[b]azepine-based selective inhibitors of human neuronal nitric oxide synthase (nNOS).	Neuraxon
21923116	40	Discovery of N-(3-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indol-6-yl) thiophene-2-carboximidamide as a selective inhibitor of human neuronal nitric oxide synthase (nNOS) for the treatment of pain.	Neuraxon
18083522	15	N(delta)-Methylated L-arginine derivatives and their effects on the nitric oxide generating system.	Christian-Albrechts-University of Kiel
18024030	110	Discovery of a series of aminopiperidines as novel iNOS inhibitors.	Adolor
17317165	77	Novel 2-aminobenzothiazoles as selective neuronal nitric oxide synthase inhibitors.	Neuraxon
15357988	87	Evaluation of pyrrolidin-2-imines and 1,3-thiazolidin-2-imines as inhibitors of nitric oxide synthase.	Merck Research Laboratory
15357982	18	Substituted 6-phenyl-pyridin-2-ylamines: selective and potent inhibitors of neuronal nitric oxide synthase.	Pfizer
14761191	19	5-Fluorinated L-lysine analogues as selective induced nitric oxide synthase inhibitors.	Pfizer
12620067	47	1,2-Dihydro-4-quinazolinamines: potent, highly selective inhibitors of inducible nitric oxide synthase which show antiinflammatory activity in vivo.	Astrazeneca R&D Charnwood
14667223	72	Computer modeling of selective regions in the active site of nitric oxide synthases: implication for the design of isoform-selective inhibitors.	Northwestern University
11931623	6	Synthesis and biological characterization of L-N(6)-(1-iminoethyl)lysine 5-tetrazole-amide, a prodrug of a selective iNOS inhibitor.	Pfizer
9554868	40	2-Iminohomopiperidinium salts as selective inhibitors of inducible nitric oxide synthase (iNOS).	Pfizer
9733492	54	2-Iminopyrrolidines as potent and selective inhibitors of human inducible nitric oxide synthase.	Pfizer
9667974	150	N-Phenylamidines as selective inhibitors of human neuronal nitric oxide synthase: structure-activity studies and demonstration of in vivo activity.	Glaxo Wellcome Research and Development
9191968	88	Substituted N-phenylisothioureas: potent inhibitors of human nitric oxide synthase with neuronal isoform selectivity.	Glaxo Wellcome Research and Development
8576908	33	2-Iminopiperidine and other 2-iminoazaheterocycles as potent inhibitors of human nitric oxide synthase isoforms.	G. D. Searle Research and Development
12781178	33	Dihydroquinolines with amine-containing side chains as potent n-NOS inhibitors.	Schering
10741561	48	Inhibition of inducible nitric oxide synthase by acetamidine derivatives of hetero-substituted lysine and homolysine.	Glaxo Wellcome Research and Development
22318159	36	3,5-Disubstituted indole derivatives as selective human neuronal nitric oxide synthase (nNOS) inhibitors.	Neuraxon
22175766	45	Discovery of cis-N-(1-(4-(methylamino)cyclohexyl)indolin-6-yl)thiophene-2-carboximidamide: a 1,6-disubstituted indoline derivative as a highly selective inhibitor of human neuronal nitric oxide synthase (nNOS) without any cardiovascular liabilities.	Neuraxon
22182498	71	Heteroaromatic-aminomethyl quinolones: potent and selective iNOS inhibitors.	Afraxis
21699209	75	Design, synthesis, and biological evaluation of 3,4-dihydroquinolin-2(1H)-one and 1,2,3,4-tetrahydroquinoline-based selective human neuronal nitric oxide synthase (nNOS) inhibitors.	Neuraxon
21986586	124	Identification and SAR of selective inducible nitric oxide synthase (iNOS) dimerization inhibitors.	Kalypsys
21824773	46	1,6-Disubstituted indole derivatives as selective human neuronal nitric oxide synthase inhibitors.	Neuraxon
21813276	56	1,5-Disubstituted indole derivatives as selective human neuronal nitric oxide synthase inhibitors.	Neuraxon
20931971	155	Discovery of dual inducible/neuronal nitric oxide synthase (iNOS/nNOS) inhibitor development candidate 4-((2-cyclobutyl-1H-imidazo[4,5-b]pyrazin-1-yl)methyl)-7,8-difluoroquinolin-2(1H)-one (KD7332) part 2: identification of a novel, potent, and selective series of benzimidazole-quinolinone iNOS/nNO	Kalypsys
21482467	28	Heteroalicyclic carboxamidines as inhibitors of inducible nitric oxide synthase; the identification of (2R)-2-pyrrolidinecarboxamidine as a potent and selective haem-co-ordinating inhibitor.	Glaxosmithkline
21410186	43	Symmetric double-headed aminopyridines, a novel strategy for potent and membrane-permeable inhibitors of neuronal nitric oxide synthase.	Northwestern University
19203270	14	Synthesis, biological evaluation, and docking studies of N-substituted acetamidines as selective inhibitors of inducible nitric oxide synthase.	Universita G. D'Annunzio
	44	Inhibition of nitric oxide synthase by benzoxazolones	TBA
	24	Conformationally restricted arginine analogues as inhibitors of human nitric oxide synthase	TBA
	10	1,2-diaminobenzimidazoles : Selective inhibitors of nitric oxide synthase derived from aminoguanidine	TBA
19323559	19	Design and synthesis of 2-amino-4-methylpyridine analogues as inhibitors for inducible nitric oxide synthase and in vivo evaluation of [18F]6-(2-fluoropropyl)-4-methyl-pyridin-2-amine as a potential PET tracer for inducible nitric oxide synthase.	Washington University
16033258	51	Structural analysis of isoform-specific inhibitors targeting the tetrahydrobiopterin binding site of human nitric oxide synthases.	Sanofi-Aventis
15911272	21	Evaluation of 3-substituted arginine analogs as selective inhibitors of human nitric oxide synthase isozymes.	Nagoya City University
15808455	39	Bicyclic amidine inhibitors of nitric oxide synthase: discovery of perhydro-iminopyrindine and perhydro-iminoquinoline as potent, orally active inhibitors of inducible nitric oxide synthase.	Merck Research Laboratories
15501067	51	Synthesis of analogs of (1,4)-3- and 5-imino oxazepane, thiazepane, and diazepane as inhibitors of nitric oxide synthases.	Merck Research Laboratories
15163211	51	2-aminopyridines as highly selective inducible nitric oxide synthase inhibitors. Differential binding modes dependent on nitrogen substitution.	Astrazeneca R&D Charnwood
14998342	73	Structure-activity relationships of potent, selective inhibitors of neuronal nitric oxide synthase based on the 6-phenyl-2-aminopyridine structure.	Pfizer
14741281	36	Fluorinated dihydroquinolines as potent n-NOS inhibitors.	Schering
12392746	18	3-Hydroxy-4-methyl-5-pentyl-2-iminopyrrolidine: a potent and highly selective inducible nitric oxide synthase inhibitor.	Pharmacia
12182860	72	Dihydroquinolines as novel n-NOS inhibitors.	Schering
12161118	28	Design and synthesis of orally bioavailable inhibitors of inducible nitric oxide synthase. Part 1: synthesis and biological evaluation of dihydropyridin-2-imines.	Fukui Research Institute
11551770	40	Selective heterocyclic amidine inhibitors of human inducible nitric oxide synthase.	Pharmacia
32676156	8	Antiglioma Activity of Aryl and Amido-Aryl Acetamidine Derivatives Targeting iNOS: Synthesis and Biological Evaluation.	University "G. D'Annunzio" of Chieti-Pescara
11327581	44	Thienopyridines: nitric oxide synthase inhibitors with potent in vivo activity.	Astrazeneca R&D Charnwood
11327580	73	3,4-Dihydro-1-isoquinolinamines: a novel class of nitric oxide synthase inhibitors with a range of isoform selectivity and potency.	Astrazeneca R&D Charnwood
10987430	86	Substituted 2-aminopyridines as inhibitors of nitric oxide synthases.	Merck Research Laboratories
30802056	63	Optimization of Blood-Brain Barrier Permeability with Potent and Selective Human Neuronal Nitric Oxide Synthase Inhibitors Having a 2-Aminopyridine Scaffold.	Northwestern University
10498210	27	A new class of selective and potent inhibitors of neuronal nitric oxide synthase.	Pfizer
10346937	15	Synthesis and evaluation of new sulfur-containing L-arginine-derived inhibitors of nitric oxide synthase.	Wake Forest University
32302123	114	First Contact: 7-Phenyl-2-Aminoquinolines, Potent and Selective Neuronal Nitric Oxide Synthase Inhibitors That Target an Isoform-Specific Aspartate.	Northwestern University
9526553	6	Acetamidine lysine derivative, N-(5(S)-amino-6,7-dihydroxyheptyl)ethanimidamide dihydrochloride: a highly selective inhibitor of human inducible nitric oxide synthase.	Searle
9438025	54	Substituted 2-iminopiperidines as inhibitors of human nitric oxide synthase isoforms.	G. D. Searle Research and Development
8978842	9	Synthesis and evaluation of two positron-labeled nitric oxide synthase inhibitors, S-[11C]methylisothiourea and S-(2-[18F]fluoroethyl)isothiourea, as potential positron emission tomography tracers.	Washington University
28422508	78	Nitrile in the Hole: Discovery of a Small Auxiliary Pocket in Neuronal Nitric Oxide Synthase Leading to the Development of Potent and Selective 2-Aminoquinoline Inhibitors.	Northwestern University
28776992	110	Hydrophilic, Potent, and Selective 7-Substituted 2-Aminoquinolines as Improved Human Neuronal Nitric Oxide Synthase Inhibitors.	Northwestern University
29091437	50	Improvement of Cell Permeability of Human Neuronal Nitric Oxide Synthase Inhibitors Using Potent and Selective 2-Aminopyridine-Based Scaffolds with a Fluorobenzene Linker.	Northwestern University
24497639	38	Affinity map of bromodomain protein 4 (BRD4) interactions with the histone H4 tail and the small molecule inhibitor JQ1.	Bayer Healthcare
12784105	53	Aripiprazole, a novel atypical antipsychotic drug with a unique and robust pharmacology.	Case Western Reserve University
8863838	28	Coupling of metabotropic glutamate receptors 2 and 4 to G alpha 15, G alpha 16, and chimeric G alpha q/i proteins: characterization of new antagonists.	Upr Centre
7891350	9	Pharmacologic characterization of CI-996, a new angiotensin receptor antagonist.	Parke-Davis Pharmaceutical Research
15027867	10	Inactivation of purified human recombinant monoamine oxidases A and B by rasagiline and its analogues.	Emory University