The following articles (labelled with PubMed ID or TBD) are for your review
| PMID | Data | Article Title | Organization |
|---|
| 28337317 |
30 |
Structural Requirements of HDAC Inhibitors: SAHA Analogues Modified at the C2 Position Display HDAC6/8 Selectivity. |
Wayne State University |
| 27541357 |
58 |
Design and Synthesis of Janus Kinase 2 (JAK2) and Histone Deacetlyase (HDAC) Bispecific Inhibitors Based on Pacritinib and Evidence of Dual Pathway Inhibition in Hematological Cell Lines. |
National University of Singapore |
| 28057407 |
76 |
Bifunctional conjugates with potent inhibitory activity towards cyclooxygenase and histone deacetylase. |
Georgia Institute of Technology |
| 27717544 |
75 |
Targeting prostate cancer with compounds possessing dual activity as androgen receptor antagonists and HDAC6 inhibitors. |
Integral Biosciences |
| 27665180 |
14 |
Design and synthesis of novel HDAC8 inhibitory 2,5-disubstituted-1,3,4-oxadiazoles containing glycine and alanine hybrids with anti cancer activity. |
Acharya Nagarjuna University |
| 27650925 |
15 |
Synthesis of a selective HDAC6 inhibitor active in neuroblasts. |
University of Geneva |
| 27606546 |
218 |
Design, Synthesis, and Biological Evaluation of First-in-Class Dual Acting Histone Deacetylases (HDACs) and Phosphodiesterase 5 (PDE5) Inhibitors for the Treatment of Alzheimer's Disease. |
University of Navarra |
| 27377864 |
55 |
Kinetic and structural insights into the binding of histone deacetylase 1 and 2 (HDAC1, 2) inhibitors. |
Broad Institute of Mit and Harvard |
| 27186676 |
186 |
Development of Purine-Based Hydroxamic Acid Derivatives: Potent Histone Deacetylase Inhibitors with Marked in Vitro and in Vivo Antitumor Activities. |
West China Hospital of Sichuan University |
| 27142751 |
22 |
Targeting epigenetic reader and eraser: Rational design, synthesis and in vitro evaluation of dimethylisoxazoles derivatives as BRD4/HDAC dual inhibitors. |
China Pharmaceutical University |
| 27190592 |
24 |
Discovery of a Selective Series of Inhibitors of Plasmodium falciparum HDACs. |
Irbm Science Park |
| 27177826 |
2 |
Synergistic potentiation of (-)-lomaiviticin A cytotoxicity by the ATR inhibitor VE-821. |
Yale University |
| 26996372 |
10 |
Identification of new quinic acid derivatives as histone deacetylase inhibitors by fluorescence-based cellular assay. |
Sungkyunkwan University |
| 26890116 |
30 |
Biphenyl-4-yl-acrylohydroxamic acids: Identification of a novel indolyl-substituted HDAC inhibitor with antitumor activity. |
University of Milan |
| 27060764 |
30 |
Computer-aided identification of new histone deacetylase 6 selective inhibitor with anti-sepsis activity. |
Sungkyunkwan University |
| 26443078 |
108 |
Discovery of Selective Histone Deacetylase 6 Inhibitors Using the Quinazoline as the Cap for the Treatment of Cancer. |
Sichuan University |
| 26890114 |
56 |
Design, synthesis and biological evaluation of bisthiazole-based trifluoromethyl ketone derivatives as potent HDAC inhibitors with improved cellular efficacy. |
Shanghai Institute of Materia Medica |
| 26681404 |
40 |
Design and Synthesis of Simplified Largazole Analogues as Isoform-Selective Human Lysine Deacetylase Inhibitors. |
Washington University |
| 26814680 |
71 |
Identification of N-(6-mercaptohexyl)-3-(4-pyridyl)-1H-pyrazole-5-carboxamide and its disulfide prodrug as potent histone deacetylase inhibitors with in vitro and in vivo anti-tumor efficacy. |
Shenyang Pharmaceutical University |
| 26804233 |
38 |
Dissecting structure-activity-relationships of crebinostat: Brain penetrant HDAC inhibitors for neuroepigenetic regulation. |
Massachusetts General Hospital |
| 26706171 |
138 |
Novel thiol-based histone deacetylase inhibitors bearing 3-phenyl-1H-pyrazole-5-carboxamide scaffold as surface recognition motif: Design, synthesis and SAR study. |
Shenyang Pharmaceutical University |
| 26689485 |
18 |
Orally available stilbene derivatives as potent HDAC inhibitors with antiproliferative activities and antitumor effects in human tumor xenografts. |
Orchid Chemicals & Pharmaceuticals |
| 26741358 |
56 |
Design, synthesis and biological evaluation of N-phenylquinazolin-4-amine hybrids as dual inhibitors of VEGFR-2 and HDAC. |
China Pharmaceutical University |
| 26629860 |
58 |
Synthesis, biological characterization and molecular modeling insights of spirochromanes as potent HDAC inhibitors. |
European Institute of Oncology |
| 26753813 |
22 |
Design and synthesis of an activity-based protein profiling probe derived from cinnamic hydroxamic acid. |
University of Minnesota |
| 26639764 |
17 |
Synthesis and biological activity of diisothiocyanate-derived mercapturic acids. |
Wroclaw University of Technology |
| 26475519 |
40 |
Hybrids from 4-anilinoquinazoline and hydroxamic acid as dual inhibitors of vascular endothelial growth factor receptor-2 and histone deacetylase. |
China Pharmaceutical University |
| 26241876 |
1 |
Triazine as a promising scaffold for its versatile biological behavior. |
Thapar University |
| 26331334 |
99 |
Discovery of Novel Class I Histone Deacetylase Inhibitors with Promising in Vitro and in Vivo Antitumor Activities. |
Guangzhou Institute of Biomedicine and Health |
| 26086931 |
38 |
Strategies for the Discovery of Target-Specific or Isoform-Selective Modulators. |
Shandong University |
| 26264503 |
46 |
Discovery of 1-hydroxypyridine-2-thiones as selective histone deacetylase inhibitors and their potential application for treating leukemia. |
University of Minnesota |
| 26287310 |
87 |
Potent and Selective Inhibitors of Histone Deacetylase-3 Containing Chiral Oxazoline Capping Groups and a N-(2-Aminophenyl)-benzamide Binding Unit. |
University College London |
| 26211462 |
71 |
Design, synthesis and biological evaluation of isoquinoline-based derivatives as novel histone deacetylase inhibitors. |
The Walter and Eliza Hall Institute of Medical Research |
| 25637120 |
94 |
Evaluation of histone deacetylase inhibitors (HDACi) as therapeutic leads for human African trypanosomiasis (HAT). |
St. Jude Children'S Research Hospital |
| 22344701 |
30 |
Biocatalytic synthesis and structure elucidation of cyclized metabolites of the deacetylase inhibitor panobinostat (LBH589). |
Novartis Institutes For Biomedical Research |
| 25147612 |
25 |
Modulation of Activity Profiles for Largazole-Based HDAC Inhibitors through Alteration of Prodrug Properties. |
University of Florida |
| 25261927 |
80 |
Design, synthesis and biological evaluation of 4-anilinothieno[2,3-d]pyrimidine-based hydroxamic acid derivatives as novel histone deacetylase inhibitors. |
The Walter and Eliza Hall Institute of Medical Research |
| 26054247 |
48 |
Modular synthesis and biological activity of pyridyl-based analogs of the potent Class I Histone Deacetylase Inhibitor Largazole. |
Colorado State University |
| 26100440 |
6 |
Design, synthesis and preliminary biological evaluation of indoline-2,3-dione derivatives as novel HDAC inhibitors. |
Shandong University |
| 26035239 |
1 |
Natural Product Primary Sulfonamides and Primary Sulfamates. |
Griffith University |
| 25974739 |
17 |
Dual-Mode HDAC Prodrug for Covalent Modification and Subsequent Inhibitor Release. |
University of California |
| 25906087 |
14 |
Design, synthesis, and antitumor evaluation of novel histone deacetylase inhibitors equipped with a phenylsulfonylfuroxan module as a nitric oxide donor. |
Shandong University |
| 25905694 |
24 |
Novel histone deacetylase inhibitors induce growth arrest, apoptosis, and differentiation in sarcoma cancer stem cells. |
Istituto Ortopedico Rizzoli (Ior) |
| 25811792 |
32 |
Discovery of Orally Available Runt-Related Transcription Factor 3 (RUNX3) Modulators for Anticancer Chemotherapy by Epigenetic Activation and Protein Stabilization. |
Yonsei University |
| 25805446 |
30 |
Design, synthesis and biological evaluation of colchicine derivatives as novel tubulin and histone deacetylase dual inhibitors. |
East China Normal University |
| 25800646 |
40 |
Macrocyclic compounds as anti-cancer agents: design and synthesis of multi-acting inhibitors against HDAC, FLT3 and JAK2. |
Central South University |
| 25113875 |
14 |
Indole-3-ethylsulfamoylphenylacrylamides: potent histone deacetylase inhibitors with anti-inflammatory activity. |
Taipei Medical University |
| 25070421 |
33 |
Evaluation of class I HDAC isoform selectivity of largazole analogues. |
Duke University |
| 25042254 |
7 |
Novel inhibitors of human histone deacetylases: design, synthesis and bioactivity of 3-alkenoylcoumarines. |
H�Pital Kirchberg |
| 24999749 |
1 |
A potent HDAC inhibitor, 1-alaninechlamydocin, from a Tolypocladium sp. induces G2/M cell cycle arrest and apoptosis in MIA PaCa-2 cells. |
University of Oklahoma |
| 24864038 |
112 |
Design and synthesis of novel and highly-active pan-histone deacetylase (pan-HDAC) inhibitors. |
Nippon Pharmaceutical Chemicals |
| 25563890 |
49 |
Hydroxamic acid based histone deacetylase inhibitors with confirmed activity against the malaria parasite. |
R&D Sigma-Tau Industrie Farmaceutiche Riunite |
| 25462271 |
33 |
Development of 3-hydroxycinnamamide-based HDAC inhibitors with potent in vitro and in vivo anti-tumor activity. |
Shandong University |
| 25455492 |
22 |
Aurones as histone deacetylase inhibitors: identification of key features. |
University of Geneva |
| 25454270 |
82 |
Histone deacetylase inhibitors derived from 1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine and related heterocycles selective for the HDAC6 isoform. |
TBA |
| 25380299 |
61 |
Methyl effect in azumamides provides insight into histone deacetylase inhibition by macrocycles. |
Technical University of Denmark |
| 25238284 |
52 |
Identification of a novel aminotetralin class of HDAC6 and HDAC8 selective inhibitors. |
Roche Pharmaceutical Research and Early Development |
| 25233084 |
247 |
ST7612AA1, a thioacetate-¿(¿-lactam carboxamide) derivative selected from a novel generation of oral HDAC inhibitors. |
R&D Sigma-Tau Industrie Farmaceutiche Riunite |
| 25218912 |
103 |
Design, synthesis, and biological evaluation of 1, 3-disubstituted-pyrazole derivatives as new class I and IIb histone deacetylase inhibitors. |
Chinese Academy of Sciences |
| 25176189 |
7 |
Design, synthesis and biological evaluation ofß-boswellic acid based HDAC inhibitors as inducers of cancer cell death. |
Csir-Indian Institute of Integrative Medicine |
| 24944733 |
101 |
Potent and orally efficacious bisthiazole-based histone deacetylase inhibitors. |
Chinese National Center For Drug Screening |
| 24900838 |
30 |
Delayed and Prolonged Histone Hyperacetylation with a Selective HDAC1/HDAC2 Inhibitor. |
Merck Research Laboratories |
| 24588105 |
56 |
Synthesis and evaluation of new Hsp90 inhibitors based on a 1,4,5-trisubstituted 1,2,3-triazole scaffold. |
Universit£ |
| 24565573 |
35 |
4,5,6,7-Tetrahydro-isoxazolo-[4,5-c]-pyridines as a new class of cytotoxic Hsp90 inhibitors. |
Universit£ |
| 24742384 |
90 |
Influence of the adamantyl moiety on the activity of biphenylacrylohydroxamic acid-based HDAC inhibitors. |
Universit£ |
| 24694055 |
35 |
Discovery of the first N-hydroxycinnamamide-based histone deacetylase 1/3 dual inhibitors with potent oral antitumor activity. |
Shandong University |
| 24261862 |
23 |
Design, synthesis, and biological evaluation of potent and selective class IIa histone deacetylase (HDAC) inhibitors as a potential therapy for Huntington's disease. |
Biofocus |
| 24328302 |
94 |
Protein kinase and HDAC inhibitors from the endophytic fungus Epicoccum nigrum. |
Heinrich-Heine-Universit£T D£Sseldorf |
| 24095018 |
24 |
The discovery and optimization of novel dual inhibitors of topoisomerase II and histone deacetylase. |
East China Normal University |
| 24035339 |
4 |
Synthesis and HDAC inhibitory activity of isosteric thiazoline-oxazole largazole analogs. |
Colorado State University |
| 23964961 |
9 |
Potent histone deacetylase inhibitors derived from 4-(aminomethyl)-N-hydroxybenzamide with high selectivity for the HDAC6 isoform. |
Millennium Pharmaceuticals |
| 23627282 |
10 |
Development and therapeutic implications of selective histone deacetylase 6 inhibitors. |
University of Illinois At Chicago |
| 23906422 |
1 |
Identification of novel HDAC inhibitors through cell based screening and their evaluation as potential anticancer agents. |
Translational Drug Development |
| 23829483 |
32 |
Discovery of potent, isoform-selective inhibitors of histone deacetylase containing chiral heterocyclic capping groups and a N-(2-aminophenyl)benzamide binding unit. |
University College London |
| 24015327 |
42 |
Development of a chimeric c-Src kinase and HDAC inhibitor. |
University of Michigan |
| 23644210 |
5 |
Synthesis and biological characterization of spiro[2H-(1,3)-benzoxazine-2,4'-piperidine] based histone deacetylase inhibitors. |
Congenia |
| 23602523 |
5 |
The discovery of colchicine-SAHA hybrids as a new class of antitumor agents. |
East China Normal University |
| 23591111 |
2 |
A cyclodextrin-capped histone deacetylase inhibitor. |
University of Sussex |
| 23672185 |
3 |
Discovery of the first histone deacetylase 6/8 dual inhibitors. |
Broad Institute of Mit and Harvard |
| 23368884 |
80 |
Potent and selective inhibition of histone deacetylase 6 (HDAC6) does not require a surface-binding motif. |
Broad Institute of Mit and Harvard |
| 23493449 |
8 |
Development of |
Shandong University |
| 24900575 |
31 |
Biological evaluation of new largazole analogues: alteration of macrocyclic scaffold with click chemistry. |
Chinese Academy of Sciences |
| 23089527 |
6 |
The structural requirements of histone deacetylase inhibitors: suberoylanilide hydroxamic acid analogs modified at the C6 position. |
Wayne State University |
| 23061376 |
63 |
Pharmacokinetic optimization of class-selective histone deacetylase inhibitors and identification of associated candidate predictive biomarkers of hepatocellular carcinoma tumor response. |
Roche R & D Center China |
| 23009203 |
39 |
Selective histone deacetylase 6 inhibitors bearing substituted urea linkers inhibit melanoma cell growth. |
University of Illinois At Chicago |
| 23010266 |
24 |
Novel histone deacetylase 8 ligands without a zinc chelating group: exploring an 'upside-down' binding pose. |
University of Illinois At Chicago |
| 24900543 |
27 |
Macrocyclic peptoid-Peptide hybrids as inhibitors of class I histone deacetylases. |
TBA |
| 22642300 |
160 |
Design, synthesis, and biological activity of a novel series of human sirtuin-2-selective inhibitors. |
Kyoto Prefectural University of Medicine |
| 24900500 |
21 |
Discovery of HDAC Inhibitors That Lack an Active Site Zn(2+)-Binding Functional Group. |
TBA |
| 22738629 |
47 |
CCLab--a multi-objective genetic algorithm based combinatorial library design software and an application for histone deacetylase inhibitor design. |
Chinese Academy of Sciences |
| 22541394 |
30 |
Appraisal of GABA and PABA as linker: design and synthesis of novel benzamide based histone deacetylase inhibitors. |
Guru Ghasidas University |
| 21984958 |
83 |
Potential Agents for Treating Cystic Fibrosis: Cyclic Tetrapeptides that Restore Trafficking and Activity of ¿F508-CFTR. |
TBA |
| 21874153 |
54 |
Effect of Inhibiting Histone Deacetylase with Short-Chain Carboxylic Acids and Their Hydroxamic Acid Analogs on Vertebrate Development and Neuronal Chromatin. |
Broad Institute of Harvard and Mit |
| 20472442 |
25 |
On the inhibition of histone deacetylase 8. |
University of Notre Dame |
| 20452225 |
49 |
Vitamin D receptor agonist/histone deacetylase inhibitor molecular hybrids. |
Mcgill University |
| 19705846 |
100 |
Discovery of potent and selective histone deacetylase inhibitors via focused combinatorial libraries of cyclic alpha3beta-tetrapeptides. |
The Scripps Research Institute |
| 18809328 |
64 |
Optimization of a series of potent and selective ketone histone deacetylase inhibitors. |
Irbm/Merck Research Laboratories |
| 17956988 |
14 |
Unraveling the hidden catalytic activity of vertebrate class IIa histone deacetylases. |
Istituto Di Ricerche Di Biologia Molecolare |
| 18430569 |
26 |
Development of a fluorescence polarization based assay for histone deacetylase ligand discovery. |
The Broad Institute of Harvard and Mit |
| 18182289 |
127 |
Exploration of the internal cavity of histone deacetylase (HDAC) with selective HDAC1/HDAC2 inhibitors (SHI-1:2). |
Merck Research Laboratories |
| 18247554 |
134 |
Histone deacetylase inhibitors: from bench to clinic. |
Menarini Ricerche |
| 16987657 |
45 |
A series of novel, potent, and selective histone deacetylase inhibitors. |
Irbm/Merck Research Laboratories |
| 21417419 |
5 |
Discovery, synthesis, and pharmacological evaluation of spiropiperidine hydroxamic acid based derivatives as structurally novel histone deacetylase (HDAC) inhibitors. |
Dac |
| 21721525 |
8 |
In vivo PET imaging of histone deacetylases by 18F-suberoylanilide hydroxamic acid (18F-SAHA). |
Harvard Medical School |
| 21548582 |
57 |
Design, synthesis, docking, and biological evaluation of novel diazide-containing isoxazole- and pyrazole-based histone deacetylase probes. |
University of Illinois At Chicago |
| 21889343 |
6 |
The structural requirements of histone deacetylase inhibitors: Suberoylanilide hydroxamic acid analogs modified at the C3 position display isoform selectivity. |
Wayne State University |
| 21793558 |
39 |
Thailandepsins: bacterial products with potent histone deacetylase inhibitory activities and broad-spectrum antiproliferative activities. |
University of Wisconsin-Milwaukee |
| 21634430 |
218 |
Discovery of (2E)-3-{2-butyl-1-[2-(diethylamino)ethyl]-1H-benzimidazol-5-yl}-N-hydroxyacrylamide (SB939), an orally active histone deacetylase inhibitor with a superior preclinical profile. |
S*Bio |
| 21745740 |
10 |
Synthesis and biological evaluation of piperamide analogues as HDAC inhibitors. |
East China Normal University |
| 21696956 |
243 |
A novel HDAC inhibitor with a hydroxy-pyrimidine scaffold. |
Broad Institute of Harvard and Mit |
| 21080647 |
27 |
Discovery of 2-(6-{[(6-fluoroquinolin-2-yl)methyl]amino}bicyclo[3.1.0]hex-3-yl)-N-hydroxypyrimidine-5-carboxamide (CHR-3996), a class I selective orally active histone deacetylase inhibitor. |
Chroma Therapeutics |
| 21334896 |
18 |
Discovery of histone deacetylase 8 selective inhibitors. |
Howard Hughes Medical Institute |
| 21417297 |
220 |
Oxime amides as a novel zinc binding group in histone deacetylase inhibitors: synthesis, biological activity, and computational evaluation. |
Universita` Degli Studi Di Siena |
| 21256006 |
11 |
Structure and property based design, synthesis and biological evaluation of¿-lactam based HDAC inhibitors. |
Yonsei University |
| 21145737 |
12 |
Application of p21 and klf2 reporter gene assays to identify selective histone deacetylase inhibitors for cancer therapy. |
Roche R & D Center China |
| 21073160 |
143 |
Non-Natural Macrocyclic Inhibitors of Histone Deacetylases: Design, Synthesis, and Activity |
TBA |
| 21080629 |
153 |
Novel chimeric histone deacetylase inhibitors: a series of lapatinib hybrides as potent inhibitors of epidermal growth factor receptor (EGFR), human epidermal growth factor receptor 2 (HER2), and histone deacetylase activity. |
University of Regensburg |
| 19966789 |
40 |
Reduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosis. |
The Scripps Research Institute |
| 20637529 |
15 |
Design and synthesis of novel isoxazole-based HDAC inhibitors. |
Università |
| 20223566 |
23 |
Inside HDAC with HDAC inhibitors. |
Universit£ |
| 20451378 |
107 |
Acylurea connected straight chain hydroxamates as novel histone deacetylase inhibitors: Synthesis, SAR, and in vivo antitumor activity. |
S*Bio |
| 20381359 |
17 |
Synthesis and biological activity of cyclotetrapeptide analogues of the natural HDAC inhibitor FR235222. |
Universit£ |
| 20205394 |
44 |
Conformational refinement of hydroxamate-based histone deacetylase inhibitors and exploration of 3-piperidin-3-ylindole analogues of dacinostat (LAQ824). |
Novartis Institutes For Biomedical Research |
| 20143840 |
28 |
Biological and biophysical properties of the histone deacetylase inhibitor suberoylanilide hydroxamic acid are affected by the presence of short alkyl groups on the phenyl ring. |
Umr Cnrs 6026-Universit£ |
| 20055418 |
78 |
Synthesis and biological evaluation of triazol-4-ylphenyl-bearing histone deacetylase inhibitors as anticancer agents. |
University of Illinois At Chicago |
| 20143778 |
70 |
Discovery of 7-(4-(3-ethynylphenylamino)-7-methoxyquinazolin-6-yloxy)-N-hydroxyheptanamide (CUDc-101) as a potent multi-acting HDAC, EGFR, and HER2 inhibitor for the treatment of cancer. |
Curis |
| 19906529 |
22 |
Identification of a series of substituted 2-piperazinyl-5-pyrimidylhydroxamic acids as potent histone deacetylase inhibitors. |
Ortho-Biotech Oncology Research & Development |
| 19359173 |
51 |
Exploring bis-(indolyl)methane moiety as an alternative and innovative CAP group in the design of histone deacetylase (HDAC) inhibitors. |
Sigma-Tau Research and Development |
| 19362838 |
16 |
Design and synthesis of novel hybrid benzamide-peptide histone deacetylase inhibitors. |
The Scripps Research Institute |
| 19441846 |
35 |
Discovery of a potent class I selective ketone histone deacetylase inhibitor with antitumor activity in vivo and optimized pharmacokinetic properties. |
Irbm/Merck Research Laboratories |
| 19419863 |
58 |
Isoxazole moiety in the linker region of HDAC inhibitors adjacent to the Zn-chelating group: effects on HDAC biology and antiproliferative activity. |
University of Illinois At Chicago |
| 19410459 |
33 |
Histone deacetylase inhibitors with a primary amide zinc binding group display antitumor activity in xenograft model. |
Irbm/Merck Research Laboratories |
| 19285395 |
66 |
N-Hydroxy-(4-oxime)-cinnamide: a versatile scaffold for the synthesis of novel histone deacetylase [correction of deacetilase] (HDAC) inhibitors. |
R&D Sigma-Tau |
| 19268585 |
30 |
Exploring the pharmacokinetic properties of phosphorus-containing selective HDAC 1 and 2 inhibitors (SHI-1:2). |
Merck Research Laboratories |
| 19181524 |
46 |
N-Hydroxy-1,2-disubstituted-1H-benzimidazol-5-yl acrylamides as novel histone deacetylase inhibitors: design, synthesis, SAR studies, and in vivo antitumor activity. |
S*Bio |
| 19114304 |
44 |
SAR and biological evaluation of analogues of a small molecule histone deacetylase inhibitor N-(2-aminophenyl)-4-((4-(pyridin-3-yl)pyrimidin-2-ylamino)methyl)benzamide (MGCD0103). |
Methylgene |
| 18952417 |
50 |
Studies of the metabolic stability in cells of 5-(trifluoroacetyl)thiophene-2-carboxamides and identification of more stable class II histone deacetylase (HDAC) inhibitors. |
Irbm-Merck Research Laboratories Rome |
| 18951790 |
109 |
SAR profiles of spirocyclic nicotinamide derived selective HDAC1/HDAC2 inhibitors (SHI-1:2). |
Merck Research Laboratories |
| 18930398 |
117 |
2-Trifluoroacetylthiophene oxadiazoles as potent and selective class II human histone deacetylase inhibitors. |
Irbm-Merck Research Laboratories Rome |
| 18672316 |
41 |
Novel amide derivatives as inhibitors of histone deacetylase: design, synthesis and SAR. |
Institute of Organic Synthesis |
| 18642892 |
76 |
Use of the nitrile oxide cycloaddition (NOC) reaction for molecular probe generation: a new class of enzyme selective histone deacetylase inhibitors (HDACIs) showing picomolar activity at HDAC6. |
University of Illinois At Chicago |
| 18060775 |
67 |
Optimization of biaryl Selective HDAC1&2 Inhibitors (SHI-1:2). |
Merck Research Laboratories |
| 17761416 |
53 |
The discovery of 6-amino nicotinamides as potent and selective histone deacetylase inhibitors. |
Merck Research Laboratories |
| 17691763 |
20 |
2-aroylindoles and 2-aroylbenzofurans with N-hydroxyacrylamide substructures as a novel series of rationally designed histone deacetylase inhibitors. |
University of Regensburg |
| 17606370 |
2 |
Trithiocarbonates: exploration of a new head group for HDAC inhibitors. |
Altana Pharma |
| 17555962 |
26 |
Design of novel histone deacetylase inhibitors. |
Merck Research Laboratories |
| 28196613 |
34 |
Potent and Selective EphA4 Agonists for the Treatment of ALS. |
Sanford Burnham Prebys Medical Discovery Institute |
| 25699604 |
74 |
Identification of histone deacetylase inhibitors with benzoylhydrazide scaffold that selectively inhibit class I histone deacetylases. |
University of Florida College of Medicine |
| 1586393 |
43 |
Localization and function of the D3 dopamine receptor. |
U. 109 |
| 1554381 |
19 |
Agonist activity of 2- and 5'-substituted adenosine analogs and their N6-cycloalkyl derivatives at A1- and A2-adenosine receptors coupled to adenylate cyclase. |
National Institutes of Diabetes and Digestive and Kidney Diseases |
| 1501121 |
12 |
Biochemical and pharmacological properties of SR 46349B, a new potent and selective 5-hydroxytryptamine2 receptor antagonist. |
Sanofi Recherche |
| 282646 |
50 |
Histamine H1 receptors identified in mammalian brain membranes with [3H]mepyramine. |
TBA |
| 37098 |
14 |
Binding characteristics of 3H-prazosin to rat brain alpha-adrenergic receptors. |
TBA |
| 18291323 |
20 |
Probing FtsZ and tubulin with C8-substituted GTP analogs reveals differences in their nucleotide binding sites. |
University of Amsterdam |
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