The following articles (labelled with PubMed ID or TBD) are for your review
| PMID | Data | Article Title | Organization |
|---|
| 28040393 |
7 |
Synthesis and biological evaluation of naphthoquinone-coumarin conjugates as topoisomerase II inhibitors. |
Instituto Universitario De Bio-Org£Nica (Cibican) |
| 8410993 |
24 |
Mammalian topoisomerase II inhibitory activity of 1-cyclopropyl-6,8- difluoro-1,4-dihydro-7-(2,6-dimethyl-4-pyridinyl)-4-oxo-3-quinolinecarb oxylic acid and related derivatives. |
Sterling Winthrop Pharmaceuticals Research Division |
| 14980663 |
8 |
Novel quinazoline-quinoline alkaloids with cytotoxic and DNA topoisomerase II inhibitory activities. |
Toho University |
| 15125947 |
38 |
Design, synthesis and structure-activity relationship studies of novel indazole analogues as DNA gyrase inhibitors with Gram-positive antibacterial activity. |
Dainippon Pharmaceutical |
| 12824037 |
15 |
Synthesis and biological testing of non-fluorinated analogues of levofloxacin. |
Procter & Gamble Pharmaceuticals |
| 10698436 |
1 |
Preparation of 5-(2,6-dideoxy-2-fluoro-alpha-L-talopyranosyloxy)-6-hydroxynap htho[2,3- f]quinoline-7,12-dione (FT-Alz), a new-type, potentially antitumor substance with various biological activities. |
Institute of Bioorganic Chemistry |
| 27521587 |
20 |
Quinolino[3,4-b]quinoxalines and pyridazino[4,3-c]quinoline derivatives: Synthesis, inhibition of topoisomerase IIa, G-quadruplex binding and cytotoxic properties. |
Universit£ |
| 26906637 |
2 |
Inhibition of human DNA topoisomerase IIa by two novel ellipticine derivatives. |
Vanderbilt University School of Medicine |
| 26649766 |
2 |
Synthesis and Mechanism Studies of 1,3-Benzoazolyl Substituted Pyrrolo[2,3-b]pyrazine Derivatives as Nonintercalative Topoisomerase II Catalytic Inhibitors. |
Sun Yat-Sen University |
| 25799376 |
2 |
Structure-based hybridization, synthesis and biological evaluation of novel tetracyclic heterocyclic azathioxanthone analogues as potential antitumor agents. |
Taipei Medical University |
| 26216018 |
2 |
Imine/amide-imidazole conjugates derived from 5-amino-4-cyano-N1-substituted benzyl imidazole: Microwave-assisted synthesis and anticancer activity via selective topoisomerase-II-a inhibition. |
Central University of Punjab |
| 26183545 |
47 |
4,6-Substituted-1,3,5-triazin-2(1H)-ones as monocyclic catalytic inhibitors of human DNA topoisomerase IIa targeting the ATP binding site. |
National Institute of Chemistry |
| 25286019 |
18 |
Novel DNA gyrase inhibiting spiropyrimidinetriones with a benzisoxazole scaffold: SAR and in vivo characterization. |
Astrazeneca |
| 25941559 |
1 |
Switch in Site of Inhibition: A Strategy for Structure-Based Discovery of Human Topoisomerase IIa Catalytic Inhibitors. |
National Institute of Pharmaceutical Education and Research (NIPER) |
| 25453816 |
27 |
Monocyclic 4-amino-6-(phenylamino)-1,3,5-triazines as inhibitors of human DNA topoisomerase IIa. |
National Institute of Chemistry |
| 15808469 |
32 |
Inhibitory activities against topoisomerase I and II by isoaurostatin derivatives and their structure-activity relationships. |
Kumamoto University |
| 23092389 |
5 |
Lanostanoids from fungi: a group of potential anticancer compounds. |
TBA |
| 22483608 |
2 |
Synthesis and evaluation of 2-[2-(phenylthiomethyl)-1H-benzo[d] imidazol-1-yl)acetohydrazide derivatives as antitumor agents. |
Sichuan University |
| 20371180 |
122 |
Cytotoxicity and inhibition of DNA topoisomerase I of polyhydroxylated triterpenoids and triterpenoid glycosides. |
Stephen F. Austin State University |
| 20006518 |
2 |
A diazirine-based photoaffinity etoposide probe for labeling topoisomerase II. |
University of Manitoba |
| 11754608 |
6 |
Screening of triterpenoids isolated from Phyllanthus flexuosus for DNA topoisomerase inhibitory activity. |
Osaka University of Pharmaceutical Sciences |
| 18321715 |
15 |
Synthesis of 1-/2-substituted-[1,2,3]triazolo[4,5-g]phthalazine-4,9-diones and evaluation of their cytotoxicity and topoisomerase II inhibition. |
Ewha Womans University |
| 18077363 |
314 |
A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. |
University of Oxford |
| 18083028 |
5 |
Synthesis and biological evaluation of bengacarboline derivatives. |
Universit£ |
| 8765520 |
3 |
Design, synthesis, and biological evaluation of ellipticine-estradiol conjugates. |
Purdue University |
| | 46 |
The antitumor activity of novel pyrazoloquinoline derivatives |
TBA |
| 22014228 |
10 |
Catalytic inhibition of eukaryotic topoisomerases I and II by flavonol glycosides extracted from Vicia faba and Lotus edulis. |
University of Thessaly |
| 22014547 |
2 |
Ungeremine effectively targets mammalian as well as bacterial type I and type II topoisomerases. |
University of Cagliari |
| 21644529 |
2 |
N-fused imidazoles as novel anticancer agents that inhibit catalytic activity of topoisomerase IIa and induce apoptosis in G1/S phase. |
National Institute of Pharmaceutical Education and Research (NIPER) |
| 21600681 |
4 |
Synthesis and evaluation of mansonone F derivatives as topoisomerase inhibitors. |
Sun Yat-Sen University |
| 21391686 |
12 |
Role of metalation in the topoisomerase IIa inhibition and antiproliferation activity of a series ofa-heterocyclic-N4-substituted thiosemicarbazones and their Cu(II) complexes. |
Memorial Sloan-Kettering Cancer Center |
| 20353152 |
1 |
A series of alpha-heterocyclic carboxaldehyde thiosemicarbazones inhibit topoisomerase IIalpha catalytic activity. |
Chinese Academy of Sciences |
| 19595598 |
2 |
7-((4-Substituted)piperazin-1-yl) derivatives of ciprofloxacin: synthesis and in vitro biological evaluation as potential antitumor agents. |
Universit£ |
| 19457675 |
8 |
The structure-based design, synthesis, and biological evaluation of DNA-binding amide linked bisintercalating bisanthrapyrazole anticancer compounds. |
University of Manitoba |
| 19560355 |
2 |
Discovery of a new class of catalytic topoisomerase II inhibitors targeting the ATP-binding site by structure based design. Part I. |
Novartis Institutes For Biomedical Research |
| 19364657 |
11 |
Synthesis, cytotoxic activity, DNA topoisomerase-II inhibition, molecular modeling and structure-activity relationship of 9-anilinothiazolo[5,4-b]quinoline derivatives. |
Universidad Nacional AutóNoma De MéXico |
| 18258442 |
9 |
The structure-based design, synthesis and biological evaluation of DNA-binding bisintercalating bisanthrapyrazole anticancer compounds. |
University of Manitoba |
| 12444693 |
5 |
Triterpenoid constituents isolated from the bark of Abies sachalinensis. |
Osaka University of Pharmaceutical Sciences |
| 11678653 |
1 |
Catalytic inhibition of topoisomerase IIalpha by demethylzeylasterone, a 6-oxophenolic triterpenoid from Kokoona zeylanica. |
University of Arizona |
| 11430001 |
72 |
Isoaurostatin, a novel topoisomerase inhibitor produced by Thermomonospora alba. |
Kumamoto University |
| 10757727 |
2 |
Three new triterpenoids from Peganum nigellastrum. |
Toho University |
| 9544566 |
1 |
DNA polymerase and topoisomerase II inhibitors from Psoralea corylifolia. |
Ohio State University |
| 15149679 |
6 |
Critical structural motif for the catalytic inhibition of human topoisomerase II by UK-1 and analogs. |
University of Maryland |
| 15026047 |
29 |
Inhibitory activities against topoisomerase I and II by polyhydroxybenzoyl amide derivatives and their structure-activity relationship. |
Kumamoto University |
| 32527548 |
7 |
Synthesis and evaluation of novel sulfonamide analogues of 6/7-aminoflavones as anticancer agents via topoisomerase II inhibition. |
Prof John Barnabas Post Graduate School of Biological Studies |
| 10743939 |
63 |
Synthesis and biological activities of NB-506 analogues modified at the glucose group. |
Banyu Tsukuba Research Institute |
| 31416740 |
10 |
Design, Synthesis and Anticancer Evaluation of New Substituted Thiophene-Quinoline Derivatives. |
Kyushu Institute of Technology1-1 Sensuicho |
| 31096154 |
39 |
Structure-guided optimization of 4,6-substituted-1,3,5-triazin-2(1H)-ones as catalytic inhibitors of human DNA topoisomerase II?. |
Slovenia |
| 10340602 |
100 |
Synthesis and biological activities of topoisomerase I inhibitors, 6-N-amino analogues of NB-506. |
Banyu Tsukuba Research Institute |
| 29870668 |
8 |
Discovery of Novel Topoisomerase II Inhibitors by Medicinal Chemistry Approaches. |
Shandong University |
| 31494471 |
15 |
Natural dimers of coumarin, chalcones, and resveratrol and the link between structure and pharmacology. |
Nagasaki International University |
| 32084316 |
3 |
Discovery of 4,6- |
Hubei University of Technology |
| 30959322 |
47 |
Probing structural requirements for human topoisomerase I inhibition by a novel N1-Biphenyl fluoroquinolone. |
University of Iowa |
| 32196342 |
20 |
Design, Synthesis, Dynamic Docking, Biochemical Characterization, and |
Istituto Italiano Di Tecnologia |
| 30962087 |
21 |
Structure-guided design of antibacterials that allosterically inhibit DNA gyrase. |
Glaxosmithkline |
| 31618025 |
2 |
Garcinol and Related Polyisoprenylated Benzophenones as Topoisomerase II Inhibitors: Biochemical and Molecular Modeling Studies. |
European Biomedical Research Institute of Salerno (Ebris) |
| 31675229 |
45 |
Drug Design Targeting T-Cell Factor-Driven Epithelial-Mesenchymal Transition as a Therapeutic Strategy for Colorectal Cancer. |
Colorado State University |
| 30846253 |
126 |
Design, synthesis and biological evaluation of 1,4-dihydroxyanthraquinone derivatives as anticancer agents. |
Guangxi University |
| 30698430 |
32 |
Design, Synthesis, and Biological Evaluation of Novel DNA Gyrase-Inhibiting Spiropyrimidinetriones as Potent Antibiotics for Treatment of Infections Caused by Multidrug-Resistant Gram-Positive Bacteria. |
Chinese Academy of Sciences |
| 28157593 |
6 |
Naphthalene diimide-polyamine hybrids as antiproliferative agents: Focus on the architecture of the polyamine chains. |
Alma Mater Studiorum-University of Bologna |
| 25083189 |
8 |
Selective Inhibition of Bacterial Topoisomerase I by alkynyl-bisbenzimidazoles. |
Clemson University |
| 24363888 |
32 |
Synthesis and antibacterial evaluation of anziaic acid and analogues as topoisomerase I inhibitors. |
University of Hawai'I At Hilo |
| 24456578 |
1 |
Isochromans and ?-pyrones from Penicillium corylophilum. |
Carleton University |
| 24063907 |
14 |
Further SAR studies on bicyclic basic merbarone analogues as potent antiproliferative agents. |
Universit£ |
| 24060488 |
6 |
Flavone-based analogues inspired by the natural product simocyclinone D8 as DNA gyrase inhibitors. |
Virginia Commonwealth University |
| 24013413 |
9 |
3-(3-Butylamino-2-hydroxy-propoxy)-1-hydroxy-xanthen-9-one acts as a topoisomerase II? catalytic inhibitor with low DNA damage. |
Ewha Womans University |
| 23968711 |
2 |
Design, synthesis and biological evaluation of novel mansonone E derivatives prepared via CuAAC click chemistry as topoisomerase II inhibitors. |
Sun Yat-Sen University |
| 23920485 |
2 |
Synthesis of imine-pyrazolopyrimidinones and their mechanistic interventions on anticancer activity. |
National Institute of Pharmaceutical Education and Research |
| 7769390 |
7 |
Flavonoids as DNA topoisomerase antagonists and poisons: structure-activity relationships. |
University of Illinois At Chicago |
| 8158166 |
2 |
Isolation of bioactive and other oxoaporphine alkaloids from two annonaceous plants, Xylopia aethiopica and Miliusa cf. banacea. |
Virginia Polytechnic Institute and State University |
| 8383731 |
2 |
A new bastadin from the sponge Psammaplysilla purpurea. |
University of Hawaii |
| 15914002 |
9 |
Synthetic lanostane-type triterpenoids as inhibitors of DNA topoisomerase II. |
Osaka University of Pharmaceutical Sciences |
| 15380226 |
14 |
Synthesis and antibacterial activity of novel 6-fluoro-1-[(1R,2S)-2-fluorocyclopropan-1-yl]-4-oxoquinoline-3-carboxylic acids bearing cyclopropane-fused 2-amino-8-azabicyclo[4.3.0]nonan-8-yl substituents at the C-7 position. |
Daiichi Pharmaceutical |
| 12459024 |
3 |
Synthesis and structure-activity relationships of novel 7-substituted 1,4-dihydro-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acids as antitumor agents. Part 1. |
Dainippon Pharmaceutical |
| 11170652 |
19 |
seco-Cyclothialidines: new concise synthesis, inhibitory activity toward bacterial and human DNA topoisomerases, and antibacterial properties. |
Bayer |
| 9804687 |
12 |
Synthesis and antitumor activity of new glycosides of epipodophyllotoxin, analogues of etoposide, and NK 611. |
Umr 176 Cnrs/Institut Curie |
| 9784102 |
13 |
Design of new topoisomerase II inhibitors based upon a quinobenzoxazine self-assembly model. |
The University of Texas At Austin |
| 9733489 |
24 |
Synthesis and antitumor activity of 4-aminomethylthioxanthenone and 5-aminomethylbenzothiopyranoindazole derivatives. |
Sanofi Winthrop |
| 9599244 |
4 |
Antitumor agents. 185. Synthesis and biological evaluation of tridemethylthiocolchicine analogues as novel topoisomerase II inhibitors. |
University of North Carolina At Chapel Hill |
| 7699707 |
7 |
Dicationic diarylfurans as anti-Pneumocystis carinii agents. |
Georgia State University |
| 7650675 |
25 |
9-substituted acridine derivatives with long half-life and potent antitumor activity: synthesis and structure-activity relationships. |
Sloan-Kettering Institute For Cancer Research |
| 15177438 |
3 |
6-Arylamino-7-chloro-quinazoline-5,8-diones as novel cytotoxic and DNA topoisomerase inhibitory agents. |
Ewha Womans University |
| 29885574 |
14 |
Design, synthesis, molecular modeling and anti-proliferative evaluation of novel quinoxaline derivatives as potential DNA intercalators and topoisomerase II inhibitors. |
Al-Azhar University |
| 29519604 |
22 |
Synthesis and biological evaluation of histone deacetylase and DNA topoisomerase II-Targeted inhibitors. |
Kindai University |
| 28619446 |
13 |
Design, synthesis, and evaluation of DNA topoisomerase II-targeted nucleosides. |
Kyoto University |
| 28406299 |
46 |
Discovery and Optimization of Isoquinoline Ethyl Ureas as Antibacterial Agents. |
Actelion Pharmaceuticals |
| 28919339 |
8 |
Novel xanthone-polyamine conjugates as catalytic inhibitors of human topoisomerase II?. |
Alma Mater Studiorum-University of Bologna |
| 27689733 |
11 |
Synthesis, evaluation, and CoMFA study of fluoroquinophenoxazine derivatives as bacterial topoisomerase IA inhibitors. |
University of Hawaii At Hilo |
| 28462840 |
1 |
Synthesis and biological evaluation of N-(carbobenzyloxy)-l-phenylalanine and N-(carbobenzyloxy)-l-aspartic acid-?-benzyl ester derivatives as potent topoisomerase II? inhibitors. |
Hebei University |
| 29077404 |
7 |
Pharmacophore Hybridization To Discover Novel Topoisomerase II Poisons with Promising Antiproliferative Activity. |
Istituto Italiano Di Tecnologia |
| 28342691 |
9 |
Indenocinnoline derivatives as G-quadruplex binders, topoisomerase II? inhibitors and antiproliferative agents. |
National and Kapodistrian University of Athens |
| 18022567 |
34 |
Sterol 14alpha-demethylase as a potential target for antitrypanosomal therapy: enzyme inhibition and parasite cell growth. |
Vanderbilt University |
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