The following articles (labelled with PubMed ID or TBD) are for your review
| PMID | Data | Article Title | Organization |
|---|
| 28319392 |
216 |
Scaffold Repurposing of Nucleosides (Adenosine Receptor Agonists): Enhanced Activity at the Human Dopamine and Norepinephrine Sodium Symporters. |
National Institute of Diabetes And Digestive And Kidney Diseases |
| 2879916 |
20 |
Conformationally defined adrenergic agents. 4. 1-(aminomethyl)phthalans: synthesis and pharmacological consequences of the phthalan ring oxygen atom. |
TBA |
| 12749888 |
63 |
Synthesis, pharmacology and pharmacokinetics of 3-(4-aryl-piperazin-1-ylalkyl)-uracils as uroselective alpha1A-antagonists. |
Roche Bioscience |
| 12392747 |
36 |
SB-656104-A: a novel 5-HT(7) receptor antagonist with improved in vivo properties. |
Glaxosmithkline |
| 11992776 |
70 |
Bicyclic piperazinylbenzenesulphonamides are potent and selective 5-HT6 receptor antagonists. |
Glaxosmithkline |
| 11266169 |
27 |
Design and synthesis of novel 2,3-dihydro-1H-isoindoles with high affinity and selectivity for the dopamine D3 receptor. |
Smithkline Beecham Pharmaceuticals |
| 27689727 |
46 |
Synthesis, biological evaluation and molecular modeling of 1-oxa-4-thiaspiro- and 1,4-dithiaspiro[4.5]decane derivatives as potent and selective 5-HT |
Universit£ |
| 27866818 |
84 |
The discovery of quinoline based single-ligand human H |
Glaxosmithkline |
| 27839919 |
192 |
Decahydrobenzoquinolin-5-one sigma receptor ligands: Divergent development of both sigma 1 and sigma 2 receptor selective examples. |
University of Kansas |
| 27448917 |
33 |
Synthesis and structure-activity relationships of novel arylpiperazines as potent antagonists ofa1-adrenoceptor. |
University of Bras£Lia |
| 27658792 |
24 |
Arylsulfonamide derivatives of (aryloxy)ethyl pyrrolidines and piperidines asa |
Jagiellonian University Medical College |
| 27709945 |
62 |
Design, Synthesis, and Biological Evaluation of Novel Tetrahydroprotoberberine Derivatives (THPBs) as Selectivea |
Chinese Academy of Sciences |
| 27031406 |
114 |
Design, Synthesis, and Biological Evaluation of Indoline and Indole Derivatives as Potent and Selectivea1A-Adrenoceptor Antagonists. |
Chengdu University |
| 26954848 |
38 |
Discovery of 5-Chloro-1-(5-chloro-2-(methylsulfonyl)benzyl)-2-imino-1,2-dihydropyridine-3-carboxamide (TAK-259) as a Novel, Selective, and Orally Activea1D Adrenoceptor Antagonist with Antiurinary Frequency Effects: Reducing Human Ether-a-go-go-Related Gene (hERG) Liabilities. |
Takeda Pharmaceutical |
| 26739781 |
237 |
Receptor binding profiles and quantitative structure-affinity relationships of some 5-substituted-N,N-diallyltryptamines. |
The Alexander Shulgin Research Institute |
| 26238322 |
26 |
Indolylpiperidine derivatives as potent and selectivea1B adrenoceptor antagonists. |
Toray Industries |
| 26125514 |
40 |
Discovery of Novel Indazole Derivatives as Highly Potent and Selective Humanß3-Adrenergic Receptor Agonists with the Possibility of Having No Cardiovascular Side Effects. |
Asahi Kasei Pharma |
| 25288493 |
96 |
Human alpha1-adrenoceptor subtype selectivity of substituted homobivalent 4-aminoquinolines. |
Unsw Australia |
| 25261823 |
107 |
Structure-affinity/activity relationships of 1,4-dioxa-spiro[4.5]decane based ligands ata<alpha>1 and 5-HT1A receptors. |
Universit£ |
| 26005522 |
32 |
Discovery of Quinazoline-Based Fluorescent Probes toa1-Adrenergic Receptors. |
Shandong University |
| 25695425 |
62 |
Semisynthetic Studies on and Biological Evaluation of N-Methyllaurotetanine Analogues as Ligands for 5-HT Receptors. |
City University of New York |
| 25813897 |
12 |
a-Adrenoceptor antagonistic and hypotensive properties of novel arylpiperazine derivatives of pyrrolidin-2-one. |
Jagiellonian University Medical College |
| 24881566 |
140 |
Identification of diarylsulfonamides as agonists of the free fatty acid receptor 4 (FFA4/GPR120). |
Glaxosmithkline |
| 24992070 |
51 |
High affinity ligands and potent antagonists for thea1D-adrenergic receptor. Novel 3,8-disubstituted [1]benzothieno[3,2-d]pyrimidine derivatives. |
Universit£ |
| 24559051 |
141 |
Discovery of a tetracyclic quinoxaline derivative as a potent and orally active multifunctional drug candidate for the treatment of neuropsychiatric and neurological disorders. |
Intra-Cellular Therapies |
| 23252794 |
56 |
Structure-activity relationships in 1,4-benzodioxan-related compounds. 11. (1) reversed enantioselectivity of 1,4-dioxane derivatives ina1-adrenergic and 5-HT1A receptor binding sites recognition. |
University of Camerino |
| 12643939 |
81 |
2-(Anilinomethyl)imidazolines as alpha1 adrenergic receptor agonists: alpha1a subtype selective 2'-heteroaryl compounds. |
Glaxosmithkline |
| 11844675 |
114 |
2-(anilinomethyl)imidazolines as alpha1A adrenergic receptor agonists: 2'-heteroaryl and 2'-oxime ether series. |
Glaxosmithkline |
| 11814822 |
108 |
alpha(1)-Adrenoceptor agonists: the identification of novel alpha(1A )subtype selective 2'-heteroaryl-2-(phenoxymethyl)imidazolines. |
Glaxosmithkline |
| 12419381 |
95 |
Alpha(1)-adrenoceptor activation: a comparison of 4-(anilinomethyl)imidazoles and 4-(phenoxymethyl)imidazoles to related 2-imidazolines. |
Glaxosmithkline |
| 11597419 |
105 |
2-(Anilinomethyl)imidazolines as alpha(1)-adrenoceptor agonists: the identification of alpha(1A) subtype selective 2'-carboxylic acid esters and amides. |
Glaxosmithkline |
| 22145629 |
68 |
Synthesis, biological evaluation, and docking studies of tetrahydrofuran- cyclopentanone- and cyclopentanol-based ligands acting at adrenergica1- and serotonine 5-HT1A receptors. |
Universit£ |
| 21514979 |
92 |
Novel 4-phenylpiperidine-2,6-dione derivatives. Ligands fora1-adrenoceptor subtypes. |
Universit£ |
| 20934789 |
27 |
Synthesis anda1-adrenoceptor antagonist activity of tamsulosin analogues. |
Universit£ |
| 20813529 |
48 |
Search for influence of spatial properties on affinity ata1-adrenoceptor subtypes for phenylpiperazine derivatives of phenytoin. |
Jagiellonian University Medical College |
| 20809632 |
68 |
Rigid analogues of thea2-adrenergic blocker atipamezole: small changes, big consequences. |
Pierre Fabre Research Center |
| 20801662 |
60 |
Structure-activity relationships in 1,4-benzodioxan-related compounds. 10. Novela1-adrenoreceptor antagonists related to openphendioxan: synthesis, biological evaluation, anda1d computational study. |
Universit£ |
| 20605276 |
61 |
1,3-Dioxolane-based ligands incorporating a lactam or imide moiety: structure-affinity/activity relationship at alpha1-adrenoceptor subtypes and at 5-HT1A receptors. |
Universit£ |
| 20674357 |
66 |
Novel imidazobenzazepine derivatives as dual H1/5-HT2A antagonists for the treatment of sleep disorders. |
Glaxosmithkline |
| 20185311 |
72 |
Discovery of a new series of 5-HT1A receptor agonists. |
Universit£ |
| 19447527 |
2 |
Design, synthesis and pharmacological evaluation of new 1-[3-(4-arylpiperazin-1-yl)-2-hydroxy-propyl]-3,3-diphenylpyrrolidin-2-one derivatives with antiarrhythmic, antihypertensive, and alpha-adrenolytic activity. |
Jagiellonian University Medical College |
| 19719240 |
25 |
Doxazosin-related alpha1-adrenoceptor antagonists with prostate antitumor activity. |
University of Camerino |
| 19146417 |
70 |
The discovery of a selective, small molecule agonist for the MAS-related gene X1 receptor. |
Glaxosmithkline |
| 18817363 |
84 |
Structure-activity relationships in 1,4-benzodioxan-related compounds. 9. From 1,4-benzodioxane to 1,4-dioxane ring as a promising template of novel alpha1D-adrenoreceptor antagonists, 5-HT1A full agonists, and cytotoxic agents. |
Universit£ |
| 18433113 |
124 |
Discovery of potent, orally bioavailable, selective 5-HT1A/B/D receptor antagonists. |
Glaxosmithkline |
| 17125266 |
72 |
WB4101-related compounds: new, subtype-selective alpha1-adrenoreceptor antagonists (or inverse agonists?). |
Universit£ |
| 11454468 |
35 |
Discovery and SAR of org 24598-a selective glycine uptake inhibitor. |
Organon Research And Development Group |
| 11140733 |
92 |
Phenyl benzenesulfonamides are novel and selective 5-HT6 antagonists: identification of N-(2,5-dibromo-3-fluorophenyl)-4-methoxy-3-piperazin-1-ylbenzenesulfonamide (SB-357134). |
Smithkline Beecham Pharmaceuticals |
| 22959245 |
175 |
As(1) receptor pharmacophore derived from a series of N-substituted 4-azahexacyclo[5.4.1.0(2,6).0(3,10).0(5,9).0(8,11)]dodecan-3-ols (AHDs). |
The University of Sydney |
| 23006002 |
35 |
Design, synthesis, and pharmacological evaluation of piperidin-4-yl amino aryl sulfonamides: novel, potent, selective, orally active, and brain penetrant 5-HT6 receptor antagonists. |
Suven Life Sciences |
| 22650618 |
4 |
Rediocide A, an Insecticide, induces G-protein-coupled receptor desensitization via activation of conventional protein kinase C. |
Chinese Academy of Sciences |
| 22738628 |
38 |
Moderate chemical modifications of WAY-100635 improve the selectivity for 5-HT1A versus D4 receptors. |
University of Li£Ge |
| 23124215 |
72 |
Affinity and activity profiling of unichiral 8-substituted 1,4-benzodioxane analogues of WB4101 reveals a potent and selectivea1B-adrenoceptor antagonist. |
Universit£ |
| 22985961 |
99 |
Synthesis and pharmacological investigation of azaphthalazinone human histamine H(1) receptor antagonists. |
Glaxosmithkline |
| 22607684 |
50 |
7-Azabicyclo[2.2.1]heptane as a scaffold for the development of selective sigma-2 (s2) receptor ligands. |
The University of Sydney |
| 22313227 |
78 |
Radiosynthesis and evaluation of an (18)F-labeled positron emission tomography (PET) radioligand for brain histamine subtype-3 receptors based on a nonimidazole 2-aminoethylbenzofuran chemotype. |
National Institute of Mental Health |
| 21207959 |
69 |
Syntheses of 2-amino and 2-halothiazole derivatives as high-affinity metabotropic glutamate receptor subtype 5 ligands and potential radioligands for in vivo imaging. |
National Institute of Mental Health |
| 20727749 |
17 |
Pyrazolo[1,5-a]pyrimidine acetamides: 4-Phenyl alkyl ether derivatives as potent ligands for the 18 kDa translocator protein (TSPO). |
University of Sydney |
| 20684563 |
176 |
Discovery of N-{1-[3-(3-oxo-2,3-dihydrobenzo[1,4]oxazin-4-yl)propyl]piperidin-4-yl}-2-phenylacetamide (Lu AE51090): an allosteric muscarinic M1 receptor agonist with unprecedented selectivity and procognitive potential. |
H. Lundbeck |
| 19963380 |
38 |
Synthetic studies and pharmacological evaluations on the MDMA ('Ecstasy') antagonist nantenine. |
Hunter College And The Graduate Center of The City University of New York |
| 18400496 |
112 |
Novel 2-imidazoles as potent and selective alpha1A adrenoceptor partial agonists. |
Pfizer |
| 17483457 |
58 |
A-803467, a potent and selective Nav1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat. |
Abbott Laboratories |
| 16451077 |
86 |
Pyrrolizidine esters and amides as 5-HT4 receptor agonists and antagonists. |
Pfizer |
| 16220969 |
219 |
Designed multiple ligands. An emerging drug discovery paradigm. |
Organon Laboratories |
| 15482914 |
25 |
Azaadamantane benzamide 5-HT4 agonists: gastrointestinal prokinetic SC-54750. |
Pfizer |
| 14998318 |
112 |
Selective optimization of side activities: another way for drug discovery. |
Prestwick Chemical |
| 12825930 |
16 |
New pyrimido[5,4-b]indoles as ligands for alpha(1)-adrenoceptor subtypes. |
Universit£ |
| 11585444 |
295 |
From hit to lead. Analyzing structure-profile relationships. |
Universities of Lille |
| 10579843 |
81 |
Design and synthesis of novel alpha(1)(a) adrenoceptor-selective antagonists. 4. Structure-activity relationship in the dihydropyrimidine series. |
Synaptic Pharmaceutical |
| 10579840 |
88 |
Design and synthesis of novel alpha(1)(a) adrenoceptor-selective antagonists. 1. Structure-activity relationship in dihydropyrimidinones. |
Synaptic Pharmaceutical |
| 9135028 |
114 |
Pharmacological options in the treatment of benign prostatic hyperplasia. |
Pfizer |
| 7562902 |
114 |
Alpha- and beta-adrenoceptors: from the gene to the clinic. 2. Structure-activity relationships and therapeutic applications. |
Smithkline Beecham Pharmaceuticals |
| 7752182 |
41 |
Discovery of alpha 1a-adrenergic receptor antagonists based on the L-type Ca2+ channel antagonist niguldipine. |
Synaptic Pharmaceutical |
| 1833546 |
47 |
Synthesis and pharmacological evaluation of 1-(aminomethyl)-3,4-dihydro-5-hydroxy-1H-2-benzopyrans as dopamine D1 selective ligands. |
Abbott Laboratories |
| 15203136 |
39 |
(+/-)8-Amino-5,6,7,8-tetrahydroisoquinolines as novel antinociceptive agents. |
Virginia Commonwealth University |
| 11354357 |
61 |
Two novel and potent 3-[(o-methoxyphenyl)piperazinylethyl]-5-phenylthien. |
Abbott Laboratories |
| 11078200 |
61 |
N-[1-(2-Phenylethyl)pyrrolidin-3-yl]-1-adamantanecarboxamides as novel 5-HT2 receptor antagonists. |
Welfide |
| 10987417 |
48 |
Preparation and evaluation of 1,3-diaminocyclopentane-linked dihydropyrimidinone derivatives as selective alpha1a-receptor antagonists. |
Merck Research Laboratories |
| 10522703 |
103 |
Design and synthesis of novel dihydropyridine alpha-1a antagonists. |
Synaptic Pharmaceutical |
| 9873568 |
22 |
Selective alpha-1a adrenergic receptor antagonists. Effects of pharmacophore regio- and stereochemistry on potency and selectivity. |
Merck |
| 22000209 |
54 |
Design, synthesis and in vitro evaluation of bridgehead fluoromethyl analogs of N-{2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl}-N-(pyridin-2-yl)cyclohexanecarboxamide (WAY-100635) for the 5-HT(1A) receptor. |
Vu University Medical Center |
| 21591752 |
41 |
Identification of N-propylnoraporphin-11-yl 5-(1,2-dithiolan-3-yl)pentanoate as a new anti-Parkinson's agent possessing a dopamine D2 and serotonin 5-HT1A dual-agonist profile. |
Soochow University College of Pharmaceutical Sciences |
| 21520940 |
40 |
Design, synthesis, radiolabeling, and in vitro and in vivo evaluation of bridgehead iodinated analogues of N-{2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl}-N-(pyridin-2-yl)cyclohexanecarboxamide (WAY-100635) as potential SPECT ligands for the 5-HT1A receptor. |
Vu University Medical Center |
| 20812727 |
157 |
Synthesis, structure-affinity relationships, and radiolabeling of selective high-affinity 5-HT4 receptor ligands as prospective imaging probes for positron emission tomography. |
National Institute of Mental Health |
| 20681583 |
7 |
Novel N-methylated 8-oxoisoguanines from Pacific sponges with diverse neuroactivities. |
Hokkaido University |
| 20620058 |
41 |
Smoothened antagonists for hair inhibition. |
Pfizer |
| 19857969 |
6 |
Structural basis of the selectivity of the beta(2)-adrenergic receptor for fluorinated catecholamines. |
National Institute of Diabetes And Digestive And Kidney Diseases |
| 19646882 |
72 |
Novel delta opioid receptor agonists exhibit differential stimulation of signaling pathways. |
University of Medicine And Dentistry of New Jersey-Robert Wood Johnson Medical School And The Informatics Institute of Umdnj |
| | 26 |
Hindered rotation congeners of mazapertine: High affinity ligands for the 5-HT1A receptor |
TBA |
| | 21 |
Serotonin 5-HT4 agonist activity of a series of meso-azanoradamantane benzamides |
TBA |
| | 32 |
The synthesis and biological activity of some known and putative metabolites of the atypical antipsychotic agent olanzapine (LY170053) |
TBA |
| | 14 |
Marine sponge bis(indole) alkaloids that displace ligand binding to α1 adrenergic receptors |
TBA |
| | 44 |
5-O-Carboxymethyl piperazide derivatives of serotonin: a new class of potent and selective 5-HT1D receptor agonists |
TBA |
| | 37 |
The discovery of CP-96,021 and CP-96,486, balanced, combined, potent and orally active leukotriene D4 (LTD4)/platelet activating factor (PAF) receptor antagonists. |
TBA |
| 19414260 |
85 |
6,7-Dihydro-5H-pyrrolo[1,2-a] imidazoles as potent and selective alpha1A adrenoceptor partial agonists. |
Pfizer |
| 19394220 |
71 |
Potent and selective alpha1A adrenoceptor partial agonists--novel imidazole frameworks. |
Pfizer |
| 19329329 |
183 |
Synthesis and in vitro affinities of various MDL 100907 derivatives as potential 18F-radioligands for 5-HT2A receptor imaging with PET. |
Institute of Nuclear Chemistry Johannes Gutenberg-University Mainz |
| 18378462 |
5 |
Recent advances in selective alpha1-adrenoreceptor antagonists as antihypertensive agents. |
Sinhgad College of Pharmacy |
| 17904840 |
64 |
Aminocyclohexylsulfonamides: discovery of metabolically stable alpha(1a/1d)-selective adrenergic receptor antagonists for the treatment of benign prostatic hyperplasia/lower urinary tract symptoms (BPH/LUTS). |
Johnson & Johnson Pharmaceutical Research And Development |
| 17571866 |
49 |
Synthesis and simple 18F-labeling of 3-fluoro-5-(2-(2-(fluoromethyl)thiazol-4-yl)ethynyl)benzonitrile as a high affinity radioligand for imaging monkey brain metabotropic glutamate subtype-5 receptors with positron emission tomography. |
National Institute of Mental Health |
| 17524641 |
69 |
3-Arylamino-2H-1,2,4-benzothiadiazin-5-ol 1,1-dioxides as novel and selective CXCR2 antagonists. |
Glaxosmithkline |
| 17517507 |
131 |
(Phenylpiperidinyl)cyclohexylsulfonamides: development of alpha1a/1d-selective adrenergic receptor antagonists for the treatment of benign prostatic hyperplasia/lower urinary tract symptoms (BPH/LUTS). |
Johnson & Johnson Pharmaceutical Research And Development |
| 17452102 |
227 |
(Arylpiperazinyl)cyclohexylsufonamides: discovery of alpha(1a/1d)-selective adrenergic receptor antagonists for the treatment of Benign Prostatic Hyperplasia/Lower Urinary Tract Symptoms (BPH/LUTS). |
Johnson & Johnson Pharmaceutical Research And Development |
| 17254786 |
30 |
1-Arylpiperazinyl-4-cyclohexylamine derived isoindole-1,3-diones as potent and selective alpha-1a/1d adrenergic receptor ligands. |
Johnson & Johnson Pharmaceutical Research And Development |
| 16621538 |
35 |
Evaluation of the eutomer of 4-{3-(4-chlorophenyl)-3-hydroxypyrrolidin-1-yl}-1-(4-fluorophenyl)butan-1-one, {(+)-SYA 09}, a pyrrolidine analog of haloperidol. |
Florida A&M University |
| 16458504 |
37 |
Synthesis, in vitro and in vivo evaluation of [O-methyl-11C] 2-{4-[4-(3-methoxyphenyl)piperazin-1-yl]-butyl}-4-methyl-2H-[1,2,4]-triazine-3,5-dione: a novel agonist 5-HT1A receptor PET ligand. |
Columbia University College of Physicians And Surgeons |
| 16392816 |
113 |
1-((S)-2-aminopropyl)-1H-indazol-6-ol: a potent peripherally acting 5-HT2 receptor agonist with ocular hypotensive activity. |
Alcon Research |
| 16392798 |
46 |
Synthesis and in vivo validation of [O-methyl-11C]2-{4-[4-(7-methoxynaphthalen-1-yl)piperazin- 1-yl]butyl}-4-methyl-2H-[1,2,4]triazine-3,5-dione: a novel 5-HT1A receptor agonist positron emission tomography ligand. |
Columbia University College of Physicians And Surgeons |
| 16153828 |
22 |
Bioisosteric phentolamine analogs as potent alpha-adrenergic antagonists. |
Chungbuk National University |
| 15828846 |
47 |
Synthesis and structure-activity relationship of fluoro analogues of 8-{2-[4-(4-methoxyphenyl)piperazin-1yl]ethyl}-8-azaspiro[4.5]decane-7,9-dione as selective alpha(1d)-adrenergic receptor antagonists. |
Lundbeck Research Usa |
| 15771448 |
187 |
Discovery of a new series of centrally active tricyclic isoxazoles combining serotonin (5-HT) reuptake inhibition with alpha2-adrenoceptor blocking activity. |
Janssen-Cilag |
| 15341484 |
159 |
Synthesis and structure--activity relationship in a class of indolebutylpiperazines as dual 5-HT(1A) receptor agonists and serotonin reuptake inhibitors. |
Merck |
| 15341483 |
110 |
Indolebutylamines as selective 5-HT(1A) agonists. |
Merck |
| 15149647 |
10 |
Bridgehead-methyl analog of SC-53116 as a 5-HT4 agonist. |
Pfizer |
| 15055991 |
265 |
Synthesis, screening, and molecular modeling of new potent and selective antagonists at the alpha 1d adrenergic receptor. |
Recordati |
| 14643338 |
124 |
Binding of beta-carbolines at 5-HT(2) serotonin receptors. |
Virginia Commonwealth University |
| 14611858 |
65 |
1H-Pyrazolo-[3,4-c]cyclophepta[1,2-c]thiophenes: a unique structural class of dopamine D4 selective ligands. |
Neurogen |
| 12904082 |
20 |
New potential uroselective NO-donor alpha1-antagonists. |
Università |
| 12617901 |
23 |
2-(3,4-Dihydro-1H-isoquinolin-2yl)-pyridines as a novel class of NR1/2B subtype selective NMDA receptor antagonists. |
F. Hoffmann-La Roche |
| 12361399 |
17 |
Homoazanicotine: a structure-affinity study for nicotinic acetylcholine (nACh) receptor binding. |
Universita Di Camerino |
| 12238918 |
22 |
N-[3-(1H-imidazol-4-ylmethyl)phenyl]ethanesulfonamide (ABT-866, 1),(1) a novel alpha(1)-adrenoceptor ligand with an enhanced in vitro and in vivo profile relative to phenylpropanolamine and midodrine. |
Abbott Laboratories |
| 12161153 |
39 |
Arylpiperazine substituted heterocycles as selective alpha(1a) adrenergic antagonists. |
Johnson & Johnson Pharmaceutical Research And Development |
| 12127524 |
39 |
Novel thiophene derivatives for the treatment of benign prostatic hyperplasia. |
Johnson & Johnson Pharmaceutical Research And Development |
| 11728188 |
53 |
trans-4-[4-(Methoxyphenyl)cyclohexyl]-1-arylpiperazines: a new class of potent and selective 5-HT(1A) receptor ligands as conformationally constrained analogues of 4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]-1-arylpiperazines. |
Università |
| 11514163 |
14 |
Discovery of (R)-1-[2-hydroxy-3-(4-hydroxy-phenyl)-propyl]-4-(4-methyl-benzyl)-piperidin-4-ol: a novel NR1/2B subtype selective NMDA receptor antagonist. |
F. Hoffmann-La Roche |
| 11459670 |
30 |
Cyclic imides as potent and selective alpha-1A adrenergic receptor antagonists. |
Merck |
| 11448222 |
80 |
Phenylpiperazinylalkylamino substituted pyridazinones as potent alpha(1) adrenoceptor antagonists. |
Istituto Chimico Farmaceutico E Tossicologico |
| 11384242 |
126 |
Structure-activity studies for a novel series of bicyclic substituted hexahydrobenz[e]isoindole alpha1A adrenoceptor antagonists as potential agents for the symptomatic treatment of benign prostatic hyperplasia. |
Abbott Laboratories |
| 11133073 |
12 |
Determination of the relative and absolute stereochemistry of a potent and alpha1A-selective adrenoceptor antagonist. |
Synaptic Pharmaceutical |
| 11055359 |
18 |
Novel heterocycles as selective alpha1-adrenergic receptor antagonists. |
The R. W. Johnson Pharmaceutical Research Institute |
| 10956183 |
19 |
De novo design of a novel oxazolidinone analogue as a potent and selective alpha1A adrenergic receptor antagonist with high oral bioavailability. |
Synaptic Pharmaceutical |
| 10937710 |
81 |
Selective alpha1a adrenergic receptor antagonists based on 4-aryl-3,4-dihydropyridine-2-ones. |
Merck |
| 10937709 |
87 |
Phenylacetamides as selective alpha-1A adrenergic receptor antagonists. |
Merck |
| 10893308 |
102 |
In vitro and in vivo evaluation of dihydropyrimidinone C-5 amides as potent and selective alpha(1A) receptor antagonists for the treatment of benign prostatic hyperplasia. |
Merck Research Laboratories |
| 10843225 |
36 |
Novel arylpiperazines as selective alpha1-adrenergic receptor antagonists. |
The R. W. Johnson Pharmaceutical Research Institute |
| 10841797 |
110 |
Design, synthesis, and structure-activity relationships of phthalimide-phenylpiperazines: a novel series of potent and selective alpha(1)(a)-adrenergic receptor antagonists. |
The R. W. Johnson Pharmaceutical Research Institute |
| 10673105 |
38 |
Synthesis and evaluation of furo[3,4-d]pyrimidinones as selective alpha1a-adrenergic receptor antagonists. |
Synaptic Pharmaceutical |
| 10579842 |
91 |
Design and synthesis of novel alpha(1)(a) adrenoceptor-selective antagonists. 3. Approaches to eliminate opioid agonist metabolites by using substituted phenylpiperazine side chains. |
Synaptic Pharmaceutical |
| 10579841 |
113 |
Design and synthesis of novel alpha(1)(a) adrenoceptor-selective antagonists. 2. Approaches to eliminate opioid agonist metabolites via modification of linker and 4-methoxycarbonyl-4-phenylpiperidine moiety. |
Synaptic Pharmaceutical |
| 10021947 |
44 |
4-Oxospiro[benzopyran-2,4'-piperidines] as selective alpha 1a-adrenergic receptor antagonists. |
Merck |
| 9986714 |
105 |
Synthesis, pharmacological evaluation, and structure-activity relationship and quantitative structure-activity relationship studies on novel derivatives of 2,4-diamino-6,7-dimethoxyquinazoline alpha1-adrenoceptor antagonists. |
Recordati |
| 9888842 |
21 |
Novel adrenoceptor antagonists with a tricyclic pyrrolodipyridazine skeleton. |
Università |
| 9873563 |
67 |
Design and synthesis of N-alkylated saccharins as selective alpha-1a adrenergic receptor antagonists. |
Merck |
| 9871673 |
79 |
New generation dopaminergic agents. 2. Discovery of 3-OH-phenoxyethylamine and 3-OH-N1-phenylpiperazine dopaminergic templates. |
Wyeth-Ayerst Research Laboratories |
| 9857099 |
94 |
Design and synthesis of novel alpha1a adrenoceptor-selective dihydropyridine antagonists for the treatment of benign prostatic hyperplasia. |
Synaptic Pharmaceutical |
| 9548811 |
55 |
4-Amino-2-[4-[1-(benzyloxycarbonyl)-2(S)- [[(1,1-dimethylethyl)amino]carbonyl]-piperazinyl]-6, 7-dimethoxyquinazoline (L-765,314): a potent and selective alpha1b adrenergic receptor antagonist. |
Merck |
| 9379432 |
36 |
Synthesis and pharmacological characterization of 3-[2-((3aR,9bR)-cis-6-methoxy-2,3,3a,4,5,9b-hexahydro-1H-benz[e] isoindol-2-yl)ethyl]pyrido-[3',4':4,5]thieno[3,2-d]pyrimidine-2,4 (1H,3H)-dione (A-131701): a uroselective alpha 1A adrenoceptor antagonist for the symptomatic treatment of benign pr |
Abbott Laboratories |
| 8667368 |
42 |
Synthesis, absolute configuration, and biological profile of the enantiomers of trans-[2-(2,6-dimethoxyphenoxy)ethyl] [(3-p-tolyl-2,3-dihydro-1,4-benzodioxin-2-yl)methyl]amine (mephendioxan), a potent competitive alpha 1A-adrenoreceptor antagonist. |
University of Camerino |
| 7658428 |
94 |
Alpha- and beta-adrenoceptors: from the gene to the clinic. 1. Molecular biology and adrenoceptor subclassification. |
Smithkline Beecham Pharmaceuticals |
| 1354264 |
19 |
Disodium (R,R)-5-[2-[[2-(3-chlorophenyl)-2-hydroxyethyl]-amino] propyl]-1,3-benzodioxole-2,2-dicarboxylate (CL 316,243). A potent beta-adrenergic agonist virtually specific for beta 3 receptors. A promising antidiabetic and antiobesity agent. |
American Cyanamid |
| 27288643 |
16 |
Rational design, synthesis, anti-HIV-1 RT and antimicrobial activity of novel 3-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-1-(piperazin-1-yl)propan-1-one derivatives. |
Birla Institute of Technology |
| 27049670 |
47 |
Epiblastin A Induces Reprogramming of Epiblast Stem Cells Into Embryonic Stem Cells by Inhibition of Casein Kinase 1. |
Max Planck Institute of Molecular Physiology |
| 26077890 |
33 |
Design, Synthesis, Biological Evaluation, and Docking Study of Acetylcholinesterase Inhibitors: New Acridone-1,2,4-oxadiazole-1,2,3-triazole Hybrids. |
Tehran University of Medical Sciences |
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