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PubMed code 27839919

Compile data set for download or QSAR
Found 192 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sigma non-opioid intracellular receptor 1


(Cavia porcellus (Guinea pig))
BDBM50204304
PNG
(CHEMBL3954961)
Show SMILES [H][C@]12CCN(CCC)[C@]3([H])CCC[C@]([H])([C@@H](Cc4ccccc4)C(=O)C1)[C@@]23[H] |r|
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1n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]pentazocine from guinea pig sigma1 receptor measured after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Cavia porcellus (Guinea pig))
BDBM50204312
PNG
(CHEMBL3936289)
Show SMILES [H][C@]12CCN(C)[C@]3([H])CCC[C@]([H])([C@@H](Cc4ccccc4)C(=O)C1)[C@@]23[H] |r|
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1.5n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]pentazocine from guinea pig sigma1 receptor measured after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Cavia porcellus (Guinea pig))
BDBM50204310
PNG
(CHEMBL3948140)
Show SMILES [H][C@]12CCN(CCC(C)C)[C@]3([H])CCC[C@]([H])([C@@H](Cc4ccccc4)C(=O)C1)[C@@]23[H] |r|
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2n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]pentazocine from guinea pig sigma1 receptor measured after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Cavia porcellus (Guinea pig))
BDBM50204321
PNG
(CHEMBL3904569)
Show SMILES [H][C@]12CCN(CCOC)[C@]3([H])CCC[C@]([H])([C@@H](Cc4ccccc4)C(=O)C1)[C@@]23[H] |r|
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2n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]pentazocine from guinea pig sigma1 receptor measured after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Cavia porcellus (Guinea pig))
BDBM50204323
PNG
(CHEMBL3958393)
Show SMILES [H][C@]12CCN(CCCCCCC)[C@]3([H])CCC[C@]([H])([C@@H](CC)C(=O)C1)[C@@]23[H] |r|
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2n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]pentazocine from guinea pig sigma1 receptor measured after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Cavia porcellus (Guinea pig))
BDBM50204316
PNG
(CHEMBL3945203)
Show SMILES [H][C@]12CCN(CC3CCCCC3)[C@]3([H])CCC[C@]([H])([C@@H](Cc4ccccc4)C(=O)C1)[C@@]23[H] |r|
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3n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]pentazocine from guinea pig sigma1 receptor measured after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Cavia porcellus (Guinea pig))
BDBM50204308
PNG
(CHEMBL3980626)
Show SMILES [H][C@]12CCN(Cc3cccs3)[C@]3([H])CCC[C@]([H])([C@@H](Cc4ccccc4)C(=O)C1)[C@@]23[H] |r|
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3n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]pentazocine from guinea pig sigma1 receptor measured after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Cavia porcellus (Guinea pig))
BDBM50204320
PNG
(CHEMBL3917750)
Show SMILES [H][C@]12CCN(CCC(C)C)[C@]3([H])CCC[C@]([H])([C@@H](Cc4ccc(OC)cc4)C(=O)C1)[C@@]23[H] |r|
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3n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]pentazocine from guinea pig sigma1 receptor measured after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Cavia porcellus (Guinea pig))
BDBM50204300
PNG
(CHEMBL3910552)
Show SMILES [H][C@]12CCN(Cc3nccs3)[C@]3([H])CCC[C@]([H])([C@@H](Cc4ccccc4)C(=O)C1)[C@@]23[H] |r|
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3n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]pentazocine from guinea pig sigma1 receptor measured after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Cavia porcellus (Guinea pig))
BDBM21398
PNG
(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Show SMILES OC1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H23ClFNO2/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-2-20(25)16-3-9-19(23)10-4-16/h3-10,26H,1-2,11-15H2
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4n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]pentazocine from guinea pig sigma1 receptor measured after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Cavia porcellus (Guinea pig))
BDBM50204326
PNG
(CHEMBL3918997)
Show SMILES [H][C@]12CCN(CCC(C)C)[C@]3([H])CCC[C@]([H])([C@@H](CC)C(=O)C1)[C@@]23[H] |r|
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4n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]pentazocine from guinea pig sigma1 receptor measured after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Cavia porcellus (Guinea pig))
BDBM50204305
PNG
(CHEMBL3890935)
Show SMILES [H][C@]12CCN(CC3CCCCC3)[C@]3([H])CCC[C@]([H])([C@@H](CC)C(=O)C1)[C@@]23[H] |r|
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4n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]pentazocine from guinea pig sigma1 receptor measured after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Cavia porcellus (Guinea pig))
BDBM50204307
PNG
(CHEMBL3926713)
Show SMILES [H][C@]12CCN(C)[C@]3([H])CCC[C@]([H])([C@@H](Cc4ccc(OC)cc4)C(=O)C1)[C@@]23[H] |r|
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5n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]pentazocine from guinea pig sigma1 receptor measured after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Cavia porcellus (Guinea pig))
BDBM50204317
PNG
(CHEMBL3946273)
Show SMILES [H][C@]12CCN(Cc3cccs3)[C@]3([H])CCC[C@]([H])([C@@H](CC)C(=O)C1)[C@@]23[H] |r|
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6n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]pentazocine from guinea pig sigma1 receptor measured after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Cavia porcellus (Guinea pig))
BDBM50204298
PNG
(CHEMBL3889737)
Show SMILES [H][C@@]12CCN(CCC)[C@]3([H])CCC[C@@]([H])([C@@]13[H])[C@]1(CC)C(C2)=Nc2ccccc12 |r,c:24|
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7n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]pentazocine from guinea pig sigma1 receptor measured after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Cavia porcellus (Guinea pig))
BDBM50204299
PNG
(CHEMBL3898676)
Show SMILES [H][C@]12CCN(CCC)[C@]3([H])CCC[C@]([H])([C@@H](Cc4ccc(OC)cc4)C(=O)C1)[C@@]23[H] |r|
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9n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]pentazocine from guinea pig sigma1 receptor measured after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Cavia porcellus (Guinea pig))
BDBM50204322
PNG
(CHEMBL3889749)
Show SMILES [H][C@]12CCN(CC3CCCCC3)[C@]3([H])CCC[C@]([H])([C@@H](Cc4ccc(OC)cc4)C(=O)C1)[C@@]23[H] |r|
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10n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]pentazocine from guinea pig sigma1 receptor measured after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Cavia porcellus (Guinea pig))
BDBM50204302
PNG
(CHEMBL3908975)
Show SMILES [H][C@]12CCN(CCC)[C@]3([H])CCC[C@]([H])([C@@H](CC)C(=O)C1)[C@@]23[H] |r|
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11n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]pentazocine from guinea pig sigma1 receptor measured after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Cavia porcellus (Guinea pig))
BDBM50204297
PNG
(CHEMBL3918389)
Show SMILES [H][C@]12CCN(CCOC)[C@]3([H])CCC[C@]([H])([C@@H](CC)C(=O)C1)[C@@]23[H] |r|
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26n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]pentazocine from guinea pig sigma1 receptor measured after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Cavia porcellus (Guinea pig))
BDBM50204314
PNG
(CHEMBL3981067)
Show SMILES [H][C@]12CCN(CCC)[C@]3([H])CCC[C@]([H])([C@@H](CC)[C@H](O)C1)[C@@]23[H] |r|
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55n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]pentazocine from guinea pig sigma1 receptor measured after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Cavia porcellus (Guinea pig))
BDBM50204309
PNG
(CHEMBL3970903)
Show SMILES [H][C@@]12CCC[C@@]3([H])N(CCC)CC[C@@]([H])(c4cc5ccccc5nc4[C@@H]1CC)[C@]23[H] |r|
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70n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]pentazocine from guinea pig sigma1 receptor measured after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Cavia porcellus (Guinea pig))
BDBM50204303
PNG
(CHEMBL3935644)
Show SMILES [H][C@@]12CCC[C@@]3([H])N(CCC)CC[C@@]([H])(CC(=O)C1)[C@]23[H] |r|
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126n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]pentazocine from guinea pig sigma1 receptor measured after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Cavia porcellus (Guinea pig))
BDBM50204325
PNG
(CHEMBL3945795)
Show SMILES [H][C@]12CCN(C)[C@]3([H])CCC[C@]([H])([C@@H](CC)C(=O)C1)[C@@]23[H] |r|
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137n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]pentazocine from guinea pig sigma1 receptor measured after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Cavia porcellus (Guinea pig))
BDBM50204318
PNG
(CHEMBL3959852)
Show SMILES [H][C@@]12CCC[C@@]3([H])N(CCC)CC[C@@]([H])(c4cc5cccc(OC)c5nc4[C@@H]1CC)[C@]23[H] |r|
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171n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]pentazocine from guinea pig sigma1 receptor measured after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Cavia porcellus (Guinea pig))
BDBM50204324
PNG
(CHEMBL3952259)
Show SMILES [H][C@@]12CCC[C@@]3([H])N(C)CC[C@@]([H])(c4cc5ccccc5nc4[C@@H]1CC)[C@]23[H] |r|
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189n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]pentazocine from guinea pig sigma1 receptor measured after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Cavia porcellus (Guinea pig))
BDBM50204313
PNG
(CHEMBL3951093)
Show SMILES [H][C@@]12CCC[C@@]3([H])N(CCC)CC[C@@]([H])(c4cc5cc(Cl)ccc5nc4[C@@H]1CC)[C@]23[H] |r|
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209n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]pentazocine from guinea pig sigma1 receptor measured after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50204305
PNG
(CHEMBL3890935)
Show SMILES [H][C@]12CCN(CC3CCCCC3)[C@]3([H])CCC[C@]([H])([C@@H](CC)C(=O)C1)[C@@]23[H] |r|
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278n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]U69593 from KOR (unknown origin) expressed in HEKT cells measured after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Cavia porcellus (Guinea pig))
BDBM50204311
PNG
(CHEMBL3907688)
Show SMILES [H][C@@]12CCC[C@]3([H])N(CCC)CC[C@]([H])(CC(=O)C1)[C@@]23[H] |r|
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345n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]pentazocine from guinea pig sigma1 receptor measured after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50204313
PNG
(CHEMBL3951093)
Show SMILES [H][C@@]12CCC[C@@]3([H])N(CCC)CC[C@@]([H])(c4cc5cc(Cl)ccc5nc4[C@@H]1CC)[C@]23[H] |r|
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372n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]U69593 from KOR (unknown origin) expressed in HEKT cells measured after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Cavia porcellus (Guinea pig))
BDBM50204301
PNG
(CHEMBL3927338)
Show SMILES [H][C@]12CCN(Cc3nccs3)[C@]3([H])CCC[C@]([H])([C@@H](CC)C(=O)C1)[C@@]23[H] |r|
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407n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]pentazocine from guinea pig sigma1 receptor measured after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50204306
PNG
(CHEMBL3897499)
Show SMILES [H][C@@]12CCC[C@@]3([H])N(CCC)CC[C@@]([H])(c4cc5ccc(cc5nc4[C@@H]1CC)C(F)(F)F)[C@]23[H] |r|
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416n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]U69593 from KOR (unknown origin) expressed in HEKT cells measured after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Cavia porcellus (Guinea pig))
BDBM50204306
PNG
(CHEMBL3897499)
Show SMILES [H][C@@]12CCC[C@@]3([H])N(CCC)CC[C@@]([H])(c4cc5ccc(cc5nc4[C@@H]1CC)C(F)(F)F)[C@]23[H] |r|
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423n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]pentazocine from guinea pig sigma1 receptor measured after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50204309
PNG
(CHEMBL3970903)
Show SMILES [H][C@@]12CCC[C@@]3([H])N(CCC)CC[C@@]([H])(c4cc5ccccc5nc4[C@@H]1CC)[C@]23[H] |r|
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493n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]U69593 from KOR (unknown origin) expressed in HEKT cells measured after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50204323
PNG
(CHEMBL3958393)
Show SMILES [H][C@]12CCN(CCCCCCC)[C@]3([H])CCC[C@]([H])([C@@H](CC)C(=O)C1)[C@@]23[H] |r|
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632n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from human MOR expressed in HEK cells after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50204308
PNG
(CHEMBL3980626)
Show SMILES [H][C@]12CCN(Cc3cccs3)[C@]3([H])CCC[C@]([H])([C@@H](Cc4ccccc4)C(=O)C1)[C@@]23[H] |r|
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638n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]U69593 from KOR (unknown origin) expressed in HEKT cells measured after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM50204312
PNG
(CHEMBL3936289)
Show SMILES [H][C@]12CCN(C)[C@]3([H])CCC[C@]([H])([C@@H](Cc4ccccc4)C(=O)C1)[C@@]23[H] |r|
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661n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Binding affinity to human M3 receptor expressed in CHO cells measured after 90 mins by radioligand binding assay


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50204310
PNG
(CHEMBL3948140)
Show SMILES [H][C@]12CCN(CCC(C)C)[C@]3([H])CCC[C@]([H])([C@@H](Cc4ccccc4)C(=O)C1)[C@@]23[H] |r|
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711n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]U69593 from KOR (unknown origin) expressed in HEKT cells measured after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Cavia porcellus (Guinea pig))
BDBM50204319
PNG
(CHEMBL3927917)
Show SMILES [H][C@]12CCN(C(=O)NCc3ccc(Cl)cc3)[C@]3([H])CCC[C@]([H])([C@@H](CC)C(=O)C1)[C@@]23[H] |r|
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722n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]pentazocine from guinea pig sigma1 receptor measured after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM50204312
PNG
(CHEMBL3936289)
Show SMILES [H][C@]12CCN(C)[C@]3([H])CCC[C@]([H])([C@@H](Cc4ccccc4)C(=O)C1)[C@@]23[H] |r|
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814n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]alpha-methylhistamine from human H3 receptor expressed in HEK Flp-In cells measured after 90 mins by microbeta scintillation coun...


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50204317
PNG
(CHEMBL3946273)
Show SMILES [H][C@]12CCN(Cc3cccs3)[C@]3([H])CCC[C@]([H])([C@@H](CC)C(=O)C1)[C@@]23[H] |r|
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892n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from human MOR expressed in HEK cells after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Alpha-2C adrenergic receptor


(Homo sapiens (Human))
BDBM50204306
PNG
(CHEMBL3897499)
Show SMILES [H][C@@]12CCC[C@@]3([H])N(CCC)CC[C@@]([H])(c4cc5ccc(cc5nc4[C@@H]1CC)C(F)(F)F)[C@]23[H] |r|
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1.04E+3n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]Rauwolscine from human Alpha2C receptor expressed in MDCK cells measured after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Alpha-2B adrenergic receptor


(Homo sapiens (Human))
BDBM50204306
PNG
(CHEMBL3897499)
Show SMILES [H][C@@]12CCC[C@@]3([H])N(CCC)CC[C@@]([H])(c4cc5ccc(cc5nc4[C@@H]1CC)C(F)(F)F)[C@]23[H] |r|
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1.04E+3n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]Rauwolscine from human Alpha2B receptor expressed in HEK-T cells measured after 90 mins by microbeta scintillation counting metho...


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50204316
PNG
(CHEMBL3945203)
Show SMILES [H][C@]12CCN(CC3CCCCC3)[C@]3([H])CCC[C@]([H])([C@@H](Cc4ccccc4)C(=O)C1)[C@@]23[H] |r|
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1.23E+3n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]U69593 from KOR (unknown origin) expressed in HEKT cells measured after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50204326
PNG
(CHEMBL3918997)
Show SMILES [H][C@]12CCN(CCC(C)C)[C@]3([H])CCC[C@]([H])([C@@H](CC)C(=O)C1)[C@@]23[H] |r|
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1.28E+3n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]U69593 from KOR (unknown origin) expressed in HEKT cells measured after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50204300
PNG
(CHEMBL3910552)
Show SMILES [H][C@]12CCN(Cc3nccs3)[C@]3([H])CCC[C@]([H])([C@@H](Cc4ccccc4)C(=O)C1)[C@@]23[H] |r|
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1.40E+3n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]U69593 from KOR (unknown origin) expressed in HEKT cells measured after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50204317
PNG
(CHEMBL3946273)
Show SMILES [H][C@]12CCN(Cc3cccs3)[C@]3([H])CCC[C@]([H])([C@@H](CC)C(=O)C1)[C@@]23[H] |r|
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1.47E+3n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]U69593 from KOR (unknown origin) expressed in HEKT cells measured after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor


(Homo sapiens (Human))
BDBM50204306
PNG
(CHEMBL3897499)
Show SMILES [H][C@@]12CCC[C@@]3([H])N(CCC)CC[C@@]([H])(c4cc5ccc(cc5nc4[C@@H]1CC)C(F)(F)F)[C@]23[H] |r|
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1.59E+3n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]Rauwolscine from human Alpha2A receptor expressed in MDCK cells measured after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50204322
PNG
(CHEMBL3889749)
Show SMILES [H][C@]12CCN(CC3CCCCC3)[C@]3([H])CCC[C@]([H])([C@@H](Cc4ccc(OC)cc4)C(=O)C1)[C@@]23[H] |r|
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1.60E+3n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]U69593 from KOR (unknown origin) expressed in HEKT cells measured after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM50204312
PNG
(CHEMBL3936289)
Show SMILES [H][C@]12CCN(C)[C@]3([H])CCC[C@]([H])([C@@H](Cc4ccccc4)C(=O)C1)[C@@]23[H] |r|
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1.68E+3n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]Mesulergine from human 5-HT2C receptor expressed in Flp-IN HEK cells measured after 90 mins by microbeta scintillation counting m...


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50204318
PNG
(CHEMBL3959852)
Show SMILES [H][C@@]12CCC[C@@]3([H])N(CCC)CC[C@@]([H])(c4cc5cccc(OC)c5nc4[C@@H]1CC)[C@]23[H] |r|
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1.70E+3n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]U69593 from KOR (unknown origin) expressed in HEKT cells measured after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50204305
PNG
(CHEMBL3890935)
Show SMILES [H][C@]12CCN(CC3CCCCC3)[C@]3([H])CCC[C@]([H])([C@@H](CC)C(=O)C1)[C@@]23[H] |r|
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1.90E+3n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from human MOR expressed in HEK cells after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Serotonin receptor (2b and 2c)


(Homo sapiens (Human))
BDBM50204312
PNG
(CHEMBL3936289)
Show SMILES [H][C@]12CCN(C)[C@]3([H])CCC[C@]([H])([C@@H](Cc4ccccc4)C(=O)C1)[C@@]23[H] |r|
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1.91E+3n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells measured after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Monoamine transporters; serotonin & dopamine


(Homo sapiens (Human))
BDBM50204312
PNG
(CHEMBL3936289)
Show SMILES [H][C@]12CCN(C)[C@]3([H])CCC[C@]([H])([C@@H](Cc4ccccc4)C(=O)C1)[C@@]23[H] |r|
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2.18E+3n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]WIN35428 from human DAT expressed in HEK cells measured after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50204306
PNG
(CHEMBL3897499)
Show SMILES [H][C@@]12CCC[C@@]3([H])N(CCC)CC[C@@]([H])(c4cc5ccc(cc5nc4[C@@H]1CC)C(F)(F)F)[C@]23[H] |r|
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2.36E+3n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from human MOR expressed in HEK cells after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50204324
PNG
(CHEMBL3952259)
Show SMILES [H][C@@]12CCC[C@@]3([H])N(C)CC[C@@]([H])(c4cc5ccccc5nc4[C@@H]1CC)[C@]23[H] |r|
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3.49E+3n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]U69593 from KOR (unknown origin) expressed in HEKT cells measured after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1/M5 chimeric protein


(Homo sapiens (Human))
BDBM50204312
PNG
(CHEMBL3936289)
Show SMILES [H][C@]12CCN(C)[C@]3([H])CCC[C@]([H])([C@@H](Cc4ccccc4)C(=O)C1)[C@@]23[H] |r|
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3.49E+3n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Binding affinity to human M5 receptor expressed in CHO cells measured after 90 mins by radioligand binding assay


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50204304
PNG
(CHEMBL3954961)
Show SMILES [H][C@]12CCN(CCC)[C@]3([H])CCC[C@]([H])([C@@H](Cc4ccccc4)C(=O)C1)[C@@]23[H] |r|
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3.62E+3n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]U69593 from KOR (unknown origin) expressed in HEKT cells measured after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (Human))
BDBM50204302
PNG
(CHEMBL3908975)
Show SMILES [H][C@]12CCN(CCC)[C@]3([H])CCC[C@]([H])([C@@H](CC)C(=O)C1)[C@@]23[H] |r|
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4.50E+3n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]Way100635 from human 5-HT1A receptor expressed in CHO cells measured after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50204301
PNG
(CHEMBL3927338)
Show SMILES [H][C@]12CCN(Cc3nccs3)[C@]3([H])CCC[C@]([H])([C@@H](CC)C(=O)C1)[C@@]23[H] |r|
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from human MOR expressed in HEK cells after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50204297
PNG
(CHEMBL3918389)
Show SMILES [H][C@]12CCN(CCOC)[C@]3([H])CCC[C@]([H])([C@@H](CC)C(=O)C1)[C@@]23[H] |r|
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]DADLE from human DOR expressed in HEK cells measured after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50204312
PNG
(CHEMBL3936289)
Show SMILES [H][C@]12CCN(C)[C@]3([H])CCC[C@]([H])([C@@H](Cc4ccccc4)C(=O)C1)[C@@]23[H] |r|
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]N-methylspiperone from human D2 receptor expressed in fibroblast cells measured after 90 mins by microbeta scintillation counting...


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Monoamine transporters; serotonin & dopamine


(Homo sapiens (Human))
BDBM50204306
PNG
(CHEMBL3897499)
Show SMILES [H][C@@]12CCC[C@@]3([H])N(CCC)CC[C@@]([H])(c4cc5ccc(cc5nc4[C@@H]1CC)C(F)(F)F)[C@]23[H] |r|
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]WIN35428 from human DAT expressed in HEK cells measured after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A


(Homo sapiens (Human))
BDBM50204312
PNG
(CHEMBL3936289)
Show SMILES [H][C@]12CCN(C)[C@]3([H])CCC[C@]([H])([C@@H](Cc4ccccc4)C(=O)C1)[C@@]23[H] |r|
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]GR65630 from human 5-HT3 receptor expressed in HEK-T cells measured after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50204304
PNG
(CHEMBL3954961)
Show SMILES [H][C@]12CCN(CCC)[C@]3([H])CCC[C@]([H])([C@@H](Cc4ccccc4)C(=O)C1)[C@@]23[H] |r|
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]DADLE from human DOR expressed in HEK cells measured after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor


(Homo sapiens (Human))
BDBM50204312
PNG
(CHEMBL3936289)
Show SMILES [H][C@]12CCN(C)[C@]3([H])CCC[C@]([H])([C@@H](Cc4ccccc4)C(=O)C1)[C@@]23[H] |r|
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]Rauwolscine from human Alpha2A receptor expressed in MDCK cells measured after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50204302
PNG
(CHEMBL3908975)
Show SMILES [H][C@]12CCN(CCC)[C@]3([H])CCC[C@]([H])([C@@H](CC)C(=O)C1)[C@@]23[H] |r|
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]DADLE from human DOR expressed in HEK cells measured after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50204319
PNG
(CHEMBL3927917)
Show SMILES [H][C@]12CCN(C(=O)NCc3ccc(Cl)cc3)[C@]3([H])CCC[C@]([H])([C@@H](CC)C(=O)C1)[C@@]23[H] |r|
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]DADLE from human DOR expressed in HEK cells measured after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50204303
PNG
(CHEMBL3935644)
Show SMILES [H][C@@]12CCC[C@@]3([H])N(CCC)CC[C@@]([H])(CC(=O)C1)[C@]23[H] |r|
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]DADLE from human DOR expressed in HEK cells measured after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Alpha-1D adrenergic receptor


(Homo sapiens (Human))
BDBM50204306
PNG
(CHEMBL3897499)
Show SMILES [H][C@@]12CCC[C@@]3([H])N(CCC)CC[C@@]([H])(c4cc5ccc(cc5nc4[C@@H]1CC)C(F)(F)F)[C@]23[H] |r|
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]Prazosin from human Alpha1D receptor measured after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Alpha-2C adrenergic receptor


(Homo sapiens (Human))
BDBM50204312
PNG
(CHEMBL3936289)
Show SMILES [H][C@]12CCN(C)[C@]3([H])CCC[C@]([H])([C@@H](Cc4ccccc4)C(=O)C1)[C@@]23[H] |r|
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]Rauwolscine from human Alpha2C receptor expressed in MDCK cells measured after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM50204306
PNG
(CHEMBL3897499)
Show SMILES [H][C@@]12CCC[C@@]3([H])N(CCC)CC[C@@]([H])(c4cc5ccc(cc5nc4[C@@H]1CC)C(F)(F)F)[C@]23[H] |r|
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Binding affinity to human M3 receptor expressed in CHO cells measured after 90 mins by radioligand binding assay


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50204326
PNG
(CHEMBL3918997)
Show SMILES [H][C@]12CCN(CCC(C)C)[C@]3([H])CCC[C@]([H])([C@@H](CC)C(=O)C1)[C@@]23[H] |r|
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from human MOR expressed in HEK cells after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 7 (5-HT7)


(Homo sapiens (Human))
BDBM50204312
PNG
(CHEMBL3936289)
Show SMILES [H][C@]12CCN(C)[C@]3([H])CCC[C@]([H])([C@@H](Cc4ccccc4)C(=O)C1)[C@@]23[H] |r|
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cells measured after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50204321
PNG
(CHEMBL3904569)
Show SMILES [H][C@]12CCN(CCOC)[C@]3([H])CCC[C@]([H])([C@@H](Cc4ccccc4)C(=O)C1)[C@@]23[H] |r|
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]DADLE from human DOR expressed in HEK cells measured after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50204326
PNG
(CHEMBL3918997)
Show SMILES [H][C@]12CCN(CCC(C)C)[C@]3([H])CCC[C@]([H])([C@@H](CC)C(=O)C1)[C@@]23[H] |r|
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]DADLE from human DOR expressed in HEK cells measured after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Alpha-1D adrenergic receptor


(Homo sapiens (Human))
BDBM50204312
PNG
(CHEMBL3936289)
Show SMILES [H][C@]12CCN(C)[C@]3([H])CCC[C@]([H])([C@@H](Cc4ccccc4)C(=O)C1)[C@@]23[H] |r|
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]Prazosin from human Alpha1D receptor measured after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50204325
PNG
(CHEMBL3945795)
Show SMILES [H][C@]12CCN(C)[C@]3([H])CCC[C@]([H])([C@@H](CC)C(=O)C1)[C@@]23[H] |r|
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]U69593 from KOR (unknown origin) expressed in HEKT cells measured after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50204321
PNG
(CHEMBL3904569)
Show SMILES [H][C@]12CCN(CCOC)[C@]3([H])CCC[C@]([H])([C@@H](Cc4ccccc4)C(=O)C1)[C@@]23[H] |r|
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from human MOR expressed in HEK cells after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50204301
PNG
(CHEMBL3927338)
Show SMILES [H][C@]12CCN(Cc3nccs3)[C@]3([H])CCC[C@]([H])([C@@H](CC)C(=O)C1)[C@@]23[H] |r|
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]U69593 from KOR (unknown origin) expressed in HEKT cells measured after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50204297
PNG
(CHEMBL3918389)
Show SMILES [H][C@]12CCN(CCOC)[C@]3([H])CCC[C@]([H])([C@@H](CC)C(=O)C1)[C@@]23[H] |r|
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]U69593 from KOR (unknown origin) expressed in HEKT cells measured after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50204300
PNG
(CHEMBL3910552)
Show SMILES [H][C@]12CCN(Cc3nccs3)[C@]3([H])CCC[C@]([H])([C@@H](Cc4ccccc4)C(=O)C1)[C@@]23[H] |r|
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from human MOR expressed in HEK cells after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1D


(Homo sapiens (Human))
BDBM50204312
PNG
(CHEMBL3936289)
Show SMILES [H][C@]12CCN(C)[C@]3([H])CCC[C@]([H])([C@@H](Cc4ccccc4)C(=O)C1)[C@@]23[H] |r|
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]5-CT from human 5-HT1D receptor expressed in HEK-T cells measured after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Serotonin receptor (2b and 2c)


(Homo sapiens (Human))
BDBM50204306
PNG
(CHEMBL3897499)
Show SMILES [H][C@@]12CCC[C@@]3([H])N(CCC)CC[C@@]([H])(c4cc5ccc(cc5nc4[C@@H]1CC)C(F)(F)F)[C@]23[H] |r|
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells measured after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM50204312
PNG
(CHEMBL3936289)
Show SMILES [H][C@]12CCN(C)[C@]3([H])CCC[C@]([H])([C@@H](Cc4ccccc4)C(=O)C1)[C@@]23[H] |r|
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK-T cells measured after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (Human))
BDBM50204312
PNG
(CHEMBL3936289)
Show SMILES [H][C@]12CCN(C)[C@]3([H])CCC[C@]([H])([C@@H](Cc4ccccc4)C(=O)C1)[C@@]23[H] |r|
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]Citalopram from human SERT expressed in HEK cells measured after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM50204306
PNG
(CHEMBL3897499)
Show SMILES [H][C@@]12CCC[C@@]3([H])N(CCC)CC[C@@]([H])(c4cc5ccc(cc5nc4[C@@H]1CC)C(F)(F)F)[C@]23[H] |r|
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Binding affinity to human M2 receptor expressed in CHO cells measured after 90 mins by radioligand binding assay


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1/M5 chimeric protein


(Homo sapiens (Human))
BDBM50204306
PNG
(CHEMBL3897499)
Show SMILES [H][C@@]12CCC[C@@]3([H])N(CCC)CC[C@@]([H])(c4cc5ccc(cc5nc4[C@@H]1CC)C(F)(F)F)[C@]23[H] |r|
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Binding affinity to human M5 receptor expressed in CHO cells measured after 90 mins by radioligand binding assay


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50204324
PNG
(CHEMBL3952259)
Show SMILES [H][C@@]12CCC[C@@]3([H])N(C)CC[C@@]([H])(c4cc5ccccc5nc4[C@@H]1CC)[C@]23[H] |r|
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from human MOR expressed in HEK cells after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50204307
PNG
(CHEMBL3926713)
Show SMILES [H][C@]12CCN(C)[C@]3([H])CCC[C@]([H])([C@@H](Cc4ccc(OC)cc4)C(=O)C1)[C@@]23[H] |r|
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from human MOR expressed in HEK cells after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50204316
PNG
(CHEMBL3945203)
Show SMILES [H][C@]12CCN(CC3CCCCC3)[C@]3([H])CCC[C@]([H])([C@@H](Cc4ccccc4)C(=O)C1)[C@@]23[H] |r|
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from human MOR expressed in HEK cells after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50204312
PNG
(CHEMBL3936289)
Show SMILES [H][C@]12CCN(C)[C@]3([H])CCC[C@]([H])([C@@H](Cc4ccccc4)C(=O)C1)[C@@]23[H] |r|
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from human MOR expressed in HEK cells after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50204313
PNG
(CHEMBL3951093)
Show SMILES [H][C@@]12CCC[C@@]3([H])N(CCC)CC[C@@]([H])(c4cc5cc(Cl)ccc5nc4[C@@H]1CC)[C@]23[H] |r|
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]DADLE from human DOR expressed in HEK cells measured after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50204311
PNG
(CHEMBL3907688)
Show SMILES [H][C@@]12CCC[C@]3([H])N(CCC)CC[C@]([H])(CC(=O)C1)[C@@]23[H] |r|
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from human MOR expressed in HEK cells after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50204306
PNG
(CHEMBL3897499)
Show SMILES [H][C@@]12CCC[C@@]3([H])N(CCC)CC[C@@]([H])(c4cc5ccc(cc5nc4[C@@H]1CC)C(F)(F)F)[C@]23[H] |r|
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]N-methylspiperone from D3 receptor (unknown origin) expressed in HEK-T cells measured after 90 mins by microbeta scintillation co...


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Homo sapiens (Human))
BDBM50204306
PNG
(CHEMBL3897499)
Show SMILES [H][C@@]12CCC[C@@]3([H])N(CCC)CC[C@@]([H])(c4cc5ccc(cc5nc4[C@@H]1CC)C(F)(F)F)[C@]23[H] |r|
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]Pyrilamine from human H1 receptor expressed in HEK cells measured after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50204315
PNG
(CHEMBL3916685)
Show SMILES [H][C@]12CCN([C@]3([H])CCC[C@]([H])([C@@H](CC)C(=O)C1)[C@@]23[H])S(=O)(=O)c1ccc(C)cc1 |r|
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]DADLE from human DOR expressed in HEK cells measured after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A


(Homo sapiens (Human))
BDBM50204306
PNG
(CHEMBL3897499)
Show SMILES [H][C@@]12CCC[C@@]3([H])N(CCC)CC[C@@]([H])(c4cc5ccc(cc5nc4[C@@H]1CC)C(F)(F)F)[C@]23[H] |r|
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]GR65630 from human 5-HT3 receptor expressed in HEK-T cells measured after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Homo sapiens (Human))
BDBM50204312
PNG
(CHEMBL3936289)
Show SMILES [H][C@]12CCN(C)[C@]3([H])CCC[C@]([H])([C@@H](Cc4ccccc4)C(=O)C1)[C@@]23[H] |r|
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Binding affinity to H2 receptor (unknown origin) expressed in HEKT cells measured after 90 mins by radioligand binding assay


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM50204312
PNG
(CHEMBL3936289)
Show SMILES [H][C@]12CCN(C)[C@]3([H])CCC[C@]([H])([C@@H](Cc4ccccc4)C(=O)C1)[C@@]23[H] |r|
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Binding affinity to human M2 receptor expressed in CHO cells measured after 90 mins by radioligand binding assay


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50204303
PNG
(CHEMBL3935644)
Show SMILES [H][C@@]12CCC[C@@]3([H])N(CCC)CC[C@@]([H])(CC(=O)C1)[C@]23[H] |r|
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from human MOR expressed in HEK cells after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50204317
PNG
(CHEMBL3946273)
Show SMILES [H][C@]12CCN(Cc3cccs3)[C@]3([H])CCC[C@]([H])([C@@H](CC)C(=O)C1)[C@@]23[H] |r|
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]DADLE from human DOR expressed in HEK cells measured after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1B


(Homo sapiens (Human))
BDBM50204306
PNG
(CHEMBL3897499)
Show SMILES [H][C@@]12CCC[C@@]3([H])N(CCC)CC[C@@]([H])(c4cc5ccc(cc5nc4[C@@H]1CC)C(F)(F)F)[C@]23[H] |r|
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]5-CT from human 5-HT1B receptor expressed in HEK cells measured after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (Human))
BDBM50204306
PNG
(CHEMBL3897499)
Show SMILES [H][C@@]12CCC[C@@]3([H])N(CCC)CC[C@@]([H])(c4cc5ccc(cc5nc4[C@@H]1CC)C(F)(F)F)[C@]23[H] |r|
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]LSD from human 5-HT5A receptor expressed in Flp-In CHO cells measured after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(Homo sapiens (Human))
BDBM50204312
PNG
(CHEMBL3936289)
Show SMILES [H][C@]12CCN(C)[C@]3([H])CCC[C@]([H])([C@@H](Cc4ccccc4)C(=O)C1)[C@@]23[H] |r|
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]Prazosin from human Alpha1A receptor measured after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50204312
PNG
(CHEMBL3936289)
Show SMILES [H][C@]12CCN(C)[C@]3([H])CCC[C@]([H])([C@@H](Cc4ccccc4)C(=O)C1)[C@@]23[H] |r|
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]N-methylspiperone from D3 receptor (unknown origin) expressed in HEK-T cells measured after 90 mins by microbeta scintillation co...


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Homo sapiens (Human))
BDBM50204312
PNG
(CHEMBL3936289)
Show SMILES [H][C@]12CCN(C)[C@]3([H])CCC[C@]([H])([C@@H](Cc4ccccc4)C(=O)C1)[C@@]23[H] |r|
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]Pyrilamine from human H1 receptor expressed in HEK cells measured after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50204325
PNG
(CHEMBL3945795)
Show SMILES [H][C@]12CCN(C)[C@]3([H])CCC[C@]([H])([C@@H](CC)C(=O)C1)[C@@]23[H] |r|
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]DADLE from human DOR expressed in HEK cells measured after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50204300
PNG
(CHEMBL3910552)
Show SMILES [H][C@]12CCN(Cc3nccs3)[C@]3([H])CCC[C@]([H])([C@@H](Cc4ccccc4)C(=O)C1)[C@@]23[H] |r|
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]DADLE from human DOR expressed in HEK cells measured after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50204318
PNG
(CHEMBL3959852)
Show SMILES [H][C@@]12CCC[C@@]3([H])N(CCC)CC[C@@]([H])(c4cc5cccc(OC)c5nc4[C@@H]1CC)[C@]23[H] |r|
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University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]DADLE from human DOR expressed in HEK cells measured after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Cavia porcellus (Guinea pig))
BDBM50204315
PNG
(CHEMBL3916685)
Show SMILES [H][C@]12CCN([C@]3([H])CCC[C@]([H])([C@@H](CC)C(=O)C1)[C@@]23[H])S(=O)(=O)c1ccc(C)cc1 |r|
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]pentazocine from guinea pig sigma1 receptor measured after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M4


(Homo sapiens (Human))
BDBM50204306
PNG
(CHEMBL3897499)
Show SMILES [H][C@@]12CCC[C@@]3([H])N(CCC)CC[C@@]([H])(c4cc5ccc(cc5nc4[C@@H]1CC)C(F)(F)F)[C@]23[H] |r|
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Binding affinity to human M4 receptor expressed in CHO cells measured after 90 mins by radioligand binding assay


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50204316
PNG
(CHEMBL3945203)
Show SMILES [H][C@]12CCN(CC3CCCCC3)[C@]3([H])CCC[C@]([H])([C@@H](Cc4ccccc4)C(=O)C1)[C@@]23[H] |r|
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]DADLE from human DOR expressed in HEK cells measured after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Alpha-2B adrenergic receptor


(Homo sapiens (Human))
BDBM50204312
PNG
(CHEMBL3936289)
Show SMILES [H][C@]12CCN(C)[C@]3([H])CCC[C@]([H])([C@@H](Cc4ccccc4)C(=O)C1)[C@@]23[H] |r|
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]Rauwolscine from human Alpha2B receptor expressed in HEK-T cells measured after 90 mins by microbeta scintillation counting metho...


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (Human))
BDBM50204306
PNG
(CHEMBL3897499)
Show SMILES [H][C@@]12CCC[C@@]3([H])N(CCC)CC[C@@]([H])(c4cc5ccc(cc5nc4[C@@H]1CC)C(F)(F)F)[C@]23[H] |r|
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]5-HT from human 5-HT1E receptor expressed in HEK cells measured after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50204320
PNG
(CHEMBL3917750)
Show SMILES [H][C@]12CCN(CCC(C)C)[C@]3([H])CCC[C@]([H])([C@@H](Cc4ccc(OC)cc4)C(=O)C1)[C@@]23[H] |r|
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]DADLE from human DOR expressed in HEK cells measured after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM50204306
PNG
(CHEMBL3897499)
Show SMILES [H][C@@]12CCC[C@@]3([H])N(CCC)CC[C@@]([H])(c4cc5ccc(cc5nc4[C@@H]1CC)C(F)(F)F)[C@]23[H] |r|
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK-T cells measured after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Dopamine receptor


(Homo sapiens (Human))
BDBM50204312
PNG
(CHEMBL3936289)
Show SMILES [H][C@]12CCN(C)[C@]3([H])CCC[C@]([H])([C@@H](Cc4ccccc4)C(=O)C1)[C@@]23[H] |r|
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]SCH23390 from human D5 receptor expressed in HEK-T cells measured after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50204306
PNG
(CHEMBL3897499)
Show SMILES [H][C@@]12CCC[C@@]3([H])N(CCC)CC[C@@]([H])(c4cc5ccc(cc5nc4[C@@H]1CC)C(F)(F)F)[C@]23[H] |r|
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]Histamine from H4 receptor (unknown origin) measured after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (Human))
BDBM50204312
PNG
(CHEMBL3936289)
Show SMILES [H][C@]12CCN(C)[C@]3([H])CCC[C@]([H])([C@@H](Cc4ccccc4)C(=O)C1)[C@@]23[H] |r|
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]Nisoxetine from human NET expressed in HEK cells measured after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50204318
PNG
(CHEMBL3959852)
Show SMILES [H][C@@]12CCC[C@@]3([H])N(CCC)CC[C@@]([H])(c4cc5cccc(OC)c5nc4[C@@H]1CC)[C@]23[H] |r|
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from human MOR expressed in HEK cells after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1D


(Homo sapiens (Human))
BDBM50204306
PNG
(CHEMBL3897499)
Show SMILES [H][C@@]12CCC[C@@]3([H])N(CCC)CC[C@@]([H])(c4cc5ccc(cc5nc4[C@@H]1CC)C(F)(F)F)[C@]23[H] |r|
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]5-CT from human 5-HT1D receptor expressed in HEK-T cells measured after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50204312
PNG
(CHEMBL3936289)
Show SMILES [H][C@]12CCN(C)[C@]3([H])CCC[C@]([H])([C@@H](Cc4ccccc4)C(=O)C1)[C@@]23[H] |r|
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]U69593 from KOR (unknown origin) expressed in HEKT cells measured after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50204314
PNG
(CHEMBL3981067)
Show SMILES [H][C@]12CCN(CCC)[C@]3([H])CCC[C@]([H])([C@@H](CC)[C@H](O)C1)[C@@]23[H] |r|
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]DADLE from human DOR expressed in HEK cells measured after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50204306
PNG
(CHEMBL3897499)
Show SMILES [H][C@@]12CCC[C@@]3([H])N(CCC)CC[C@@]([H])(c4cc5ccc(cc5nc4[C@@H]1CC)C(F)(F)F)[C@]23[H] |r|
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]N-methylspiperone from human D2 receptor expressed in fibroblast cells measured after 90 mins by microbeta scintillation counting...


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50204310
PNG
(CHEMBL3948140)
Show SMILES [H][C@]12CCN(CCC(C)C)[C@]3([H])CCC[C@]([H])([C@@H](Cc4ccccc4)C(=O)C1)[C@@]23[H] |r|
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]DADLE from human DOR expressed in HEK cells measured after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50204311
PNG
(CHEMBL3907688)
Show SMILES [H][C@@]12CCC[C@]3([H])N(CCC)CC[C@]([H])(CC(=O)C1)[C@@]23[H] |r|
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]DADLE from human DOR expressed in HEK cells measured after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Adrenergic alpha1B


(Homo sapiens (Human))
BDBM50204312
PNG
(CHEMBL3936289)
Show SMILES [H][C@]12CCN(C)[C@]3([H])CCC[C@]([H])([C@@H](Cc4ccccc4)C(=O)C1)[C@@]23[H] |r|
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]Prazosin from human Alpha1B receptor expressed in HEK-T cells measured after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50204297
PNG
(CHEMBL3918389)
Show SMILES [H][C@]12CCN(CCOC)[C@]3([H])CCC[C@]([H])([C@@H](CC)C(=O)C1)[C@@]23[H] |r|
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from human MOR expressed in HEK cells after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50204298
PNG
(CHEMBL3889737)
Show SMILES [H][C@@]12CCN(CCC)[C@]3([H])CCC[C@@]([H])([C@@]13[H])[C@]1(CC)C(C2)=Nc2ccccc12 |r,c:24|
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]DADLE from human DOR expressed in HEK cells measured after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50204309
PNG
(CHEMBL3970903)
Show SMILES [H][C@@]12CCC[C@@]3([H])N(CCC)CC[C@@]([H])(c4cc5ccccc5nc4[C@@H]1CC)[C@]23[H] |r|
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]DADLE from human DOR expressed in HEK cells measured after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50204312
PNG
(CHEMBL3936289)
Show SMILES [H][C@]12CCN(C)[C@]3([H])CCC[C@]([H])([C@@H](Cc4ccccc4)C(=O)C1)[C@@]23[H] |r|
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]Histamine from H4 receptor (unknown origin) measured after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50204305
PNG
(CHEMBL3890935)
Show SMILES [H][C@]12CCN(CC3CCCCC3)[C@]3([H])CCC[C@]([H])([C@@H](CC)C(=O)C1)[C@@]23[H] |r|
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]DADLE from human DOR expressed in HEK cells measured after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50204312
PNG
(CHEMBL3936289)
Show SMILES [H][C@]12CCN(C)[C@]3([H])CCC[C@]([H])([C@@H](Cc4ccccc4)C(=O)C1)[C@@]23[H] |r|
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]DADLE from human DOR expressed in HEK cells measured after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (Human))
BDBM50204312
PNG
(CHEMBL3936289)
Show SMILES [H][C@]12CCN(C)[C@]3([H])CCC[C@]([H])([C@@H](Cc4ccccc4)C(=O)C1)[C@@]23[H] |r|
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]5-HT from human 5-HT1E receptor expressed in HEK cells measured after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50204315
PNG
(CHEMBL3916685)
Show SMILES [H][C@]12CCN([C@]3([H])CCC[C@]([H])([C@@H](CC)C(=O)C1)[C@@]23[H])S(=O)(=O)c1ccc(C)cc1 |r|
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University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from human MOR expressed in HEK cells after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50204325
PNG
(CHEMBL3945795)
Show SMILES [H][C@]12CCN(C)[C@]3([H])CCC[C@]([H])([C@@H](CC)C(=O)C1)[C@@]23[H] |r|
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from human MOR expressed in HEK cells after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50204322
PNG
(CHEMBL3889749)
Show SMILES [H][C@]12CCN(CC3CCCCC3)[C@]3([H])CCC[C@]([H])([C@@H](Cc4ccc(OC)cc4)C(=O)C1)[C@@]23[H] |r|
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from human MOR expressed in HEK cells after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50204298
PNG
(CHEMBL3889737)
Show SMILES [H][C@@]12CCN(CCC)[C@]3([H])CCC[C@@]([H])([C@@]13[H])[C@]1(CC)C(C2)=Nc2ccccc12 |r,c:24|
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from human MOR expressed in HEK cells after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50204307
PNG
(CHEMBL3926713)
Show SMILES [H][C@]12CCN(C)[C@]3([H])CCC[C@]([H])([C@@H](Cc4ccc(OC)cc4)C(=O)C1)[C@@]23[H] |r|
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]U69593 from KOR (unknown origin) expressed in HEKT cells measured after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50204312
PNG
(CHEMBL3936289)
Show SMILES [H][C@]12CCN(C)[C@]3([H])CCC[C@]([H])([C@@H](Cc4ccccc4)C(=O)C1)[C@@]23[H] |r|
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]LSD from human 5-HT6 receptor expressed in HEK cells measured after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Dopamine receptor


(Homo sapiens (Human))
BDBM50204306
PNG
(CHEMBL3897499)
Show SMILES [H][C@@]12CCC[C@@]3([H])N(CCC)CC[C@@]([H])(c4cc5ccc(cc5nc4[C@@H]1CC)C(F)(F)F)[C@]23[H] |r|
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]SCH23390 from human D5 receptor expressed in HEK-T cells measured after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (Human))
BDBM50204306
PNG
(CHEMBL3897499)
Show SMILES [H][C@@]12CCC[C@@]3([H])N(CCC)CC[C@@]([H])(c4cc5ccc(cc5nc4[C@@H]1CC)C(F)(F)F)[C@]23[H] |r|
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]Nisoxetine from human NET expressed in HEK cells measured after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50204315
PNG
(CHEMBL3916685)
Show SMILES [H][C@]12CCN([C@]3([H])CCC[C@]([H])([C@@H](CC)C(=O)C1)[C@@]23[H])S(=O)(=O)c1ccc(C)cc1 |r|
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]U69593 from KOR (unknown origin) expressed in HEKT cells measured after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50204319
PNG
(CHEMBL3927917)
Show SMILES [H][C@]12CCN(C(=O)NCc3ccc(Cl)cc3)[C@]3([H])CCC[C@]([H])([C@@H](CC)C(=O)C1)[C@@]23[H] |r|
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from human MOR expressed in HEK cells after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50204320
PNG
(CHEMBL3917750)
Show SMILES [H][C@]12CCN(CCC(C)C)[C@]3([H])CCC[C@]([H])([C@@H](Cc4ccc(OC)cc4)C(=O)C1)[C@@]23[H] |r|
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from human MOR expressed in HEK cells after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (Human))
BDBM50204312
PNG
(CHEMBL3936289)
Show SMILES [H][C@]12CCN(C)[C@]3([H])CCC[C@]([H])([C@@H](Cc4ccccc4)C(=O)C1)[C@@]23[H] |r|
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]LSD from human 5-HT5A receptor expressed in Flp-In CHO cells measured after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (Human))
BDBM50204306
PNG
(CHEMBL3897499)
Show SMILES [H][C@@]12CCC[C@@]3([H])N(CCC)CC[C@@]([H])(c4cc5ccc(cc5nc4[C@@H]1CC)C(F)(F)F)[C@]23[H] |r|
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]Citalopram from human SERT expressed in HEK cells measured after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50204323
PNG
(CHEMBL3958393)
Show SMILES [H][C@]12CCN(CCCCCCC)[C@]3([H])CCC[C@]([H])([C@@H](CC)C(=O)C1)[C@@]23[H] |r|
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]DADLE from human DOR expressed in HEK cells measured after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50204301
PNG
(CHEMBL3927338)
Show SMILES [H][C@]12CCN(Cc3nccs3)[C@]3([H])CCC[C@]([H])([C@@H](CC)C(=O)C1)[C@@]23[H] |r|
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]DADLE from human DOR expressed in HEK cells measured after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50204308
PNG
(CHEMBL3980626)
Show SMILES [H][C@]12CCN(Cc3cccs3)[C@]3([H])CCC[C@]([H])([C@@H](Cc4ccccc4)C(=O)C1)[C@@]23[H] |r|
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]DADLE from human DOR expressed in HEK cells measured after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50204306
PNG
(CHEMBL3897499)
Show SMILES [H][C@@]12CCC[C@@]3([H])N(CCC)CC[C@@]([H])(c4cc5ccc(cc5nc4[C@@H]1CC)C(F)(F)F)[C@]23[H] |r|
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]LSD from human 5-HT6 receptor expressed in HEK cells measured after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM50204306
PNG
(CHEMBL3897499)
Show SMILES [H][C@@]12CCC[C@@]3([H])N(CCC)CC[C@@]([H])(c4cc5ccc(cc5nc4[C@@H]1CC)C(F)(F)F)[C@]23[H] |r|
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Binding affinity to human M1 receptor expressed in CHO cells measured after 90 mins by radioligand binding assay


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50204311
PNG
(CHEMBL3907688)
Show SMILES [H][C@@]12CCC[C@]3([H])N(CCC)CC[C@]([H])(CC(=O)C1)[C@@]23[H] |r|
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]U69593 from KOR (unknown origin) expressed in HEKT cells measured after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50204302
PNG
(CHEMBL3908975)
Show SMILES [H][C@]12CCN(CCC)[C@]3([H])CCC[C@]([H])([C@@H](CC)C(=O)C1)[C@@]23[H] |r|
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]U69593 from KOR (unknown origin) expressed in HEKT cells measured after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50204324
PNG
(CHEMBL3952259)
Show SMILES [H][C@@]12CCC[C@@]3([H])N(C)CC[C@@]([H])(c4cc5ccccc5nc4[C@@H]1CC)[C@]23[H] |r|
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]DADLE from human DOR expressed in HEK cells measured after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(Homo sapiens (Human))
BDBM50204306
PNG
(CHEMBL3897499)
Show SMILES [H][C@@]12CCC[C@@]3([H])N(CCC)CC[C@@]([H])(c4cc5ccc(cc5nc4[C@@H]1CC)C(F)(F)F)[C@]23[H] |r|
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]Prazosin from human Alpha1A receptor measured after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50204299
PNG
(CHEMBL3898676)
Show SMILES [H][C@]12CCN(CCC)[C@]3([H])CCC[C@]([H])([C@@H](Cc4ccc(OC)cc4)C(=O)C1)[C@@]23[H] |r|
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]U69593 from KOR (unknown origin) expressed in HEKT cells measured after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM50204306
PNG
(CHEMBL3897499)
Show SMILES [H][C@@]12CCC[C@@]3([H])N(CCC)CC[C@@]([H])(c4cc5ccc(cc5nc4[C@@H]1CC)C(F)(F)F)[C@]23[H] |r|
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]alpha-methylhistamine from human H3 receptor expressed in HEK Flp-In cells measured after 90 mins by microbeta scintillation coun...


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50204313
PNG
(CHEMBL3951093)
Show SMILES [H][C@@]12CCC[C@@]3([H])N(CCC)CC[C@@]([H])(c4cc5cc(Cl)ccc5nc4[C@@H]1CC)[C@]23[H] |r|
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from human MOR expressed in HEK cells after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50204310
PNG
(CHEMBL3948140)
Show SMILES [H][C@]12CCN(CCC(C)C)[C@]3([H])CCC[C@]([H])([C@@H](Cc4ccccc4)C(=O)C1)[C@@]23[H] |r|
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from human MOR expressed in HEK cells after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50204306
PNG
(CHEMBL3897499)
Show SMILES [H][C@@]12CCC[C@@]3([H])N(CCC)CC[C@@]([H])(c4cc5ccc(cc5nc4[C@@H]1CC)C(F)(F)F)[C@]23[H] |r|
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]DADLE from human DOR expressed in HEK cells measured after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50204314
PNG
(CHEMBL3981067)
Show SMILES [H][C@]12CCN(CCC)[C@]3([H])CCC[C@]([H])([C@@H](CC)[C@H](O)C1)[C@@]23[H] |r|
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]U69593 from KOR (unknown origin) expressed in HEKT cells measured after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M4


(Homo sapiens (Human))
BDBM50204312
PNG
(CHEMBL3936289)
Show SMILES [H][C@]12CCN(C)[C@]3([H])CCC[C@]([H])([C@@H](Cc4ccccc4)C(=O)C1)[C@@]23[H] |r|
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Binding affinity to human M4 receptor expressed in CHO cells measured after 90 mins by radioligand binding assay


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50204323
PNG
(CHEMBL3958393)
Show SMILES [H][C@]12CCN(CCCCCCC)[C@]3([H])CCC[C@]([H])([C@@H](CC)C(=O)C1)[C@@]23[H] |r|
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]U69593 from KOR (unknown origin) expressed in HEKT cells measured after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50204322
PNG
(CHEMBL3889749)
Show SMILES [H][C@]12CCN(CC3CCCCC3)[C@]3([H])CCC[C@]([H])([C@@H](Cc4ccc(OC)cc4)C(=O)C1)[C@@]23[H] |r|
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]DADLE from human DOR expressed in HEK cells measured after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Beta-2 adrenergic receptor and beta-3 adrenergic receptor


(Homo sapiens (Human))
BDBM50204306
PNG
(CHEMBL3897499)
Show SMILES [H][C@@]12CCC[C@@]3([H])N(CCC)CC[C@@]([H])(c4cc5ccc(cc5nc4[C@@H]1CC)C(F)(F)F)[C@]23[H] |r|
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]CGP12177 from human beta2 receptor expressed in HEK Flp-In cells measured after 90 mins by microbeta scintillation counting metho...


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Dopamine receptors; D2 & D4


(Homo sapiens (Human))
BDBM50204312
PNG
(CHEMBL3936289)
Show SMILES [H][C@]12CCN(C)[C@]3([H])CCC[C@]([H])([C@@H](Cc4ccccc4)C(=O)C1)[C@@]23[H] |r|
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]N-methylspiperone from human D4 receptor measured after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50204320
PNG
(CHEMBL3917750)
Show SMILES [H][C@]12CCN(CCC(C)C)[C@]3([H])CCC[C@]([H])([C@@H](Cc4ccc(OC)cc4)C(=O)C1)[C@@]23[H] |r|
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]U69593 from KOR (unknown origin) expressed in HEKT cells measured after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50204309
PNG
(CHEMBL3970903)
Show SMILES [H][C@@]12CCC[C@@]3([H])N(CCC)CC[C@@]([H])(c4cc5ccccc5nc4[C@@H]1CC)[C@]23[H] |r|
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from human MOR expressed in HEK cells after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50204307
PNG
(CHEMBL3926713)
Show SMILES [H][C@]12CCN(C)[C@]3([H])CCC[C@]([H])([C@@H](Cc4ccc(OC)cc4)C(=O)C1)[C@@]23[H] |r|
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]DADLE from human DOR expressed in HEK cells measured after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))
BDBM50204312
PNG
(CHEMBL3936289)
Show SMILES [H][C@]12CCN(C)[C@]3([H])CCC[C@]([H])([C@@H](Cc4ccccc4)C(=O)C1)[C@@]23[H] |r|
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]Ketanserin from 5-HT2A receptor (unknown origin) measured after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Beta-2 adrenergic receptor and beta-3 adrenergic receptor


(Homo sapiens (Human))
BDBM50204312
PNG
(CHEMBL3936289)
Show SMILES [H][C@]12CCN(C)[C@]3([H])CCC[C@]([H])([C@@H](Cc4ccccc4)C(=O)C1)[C@@]23[H] |r|
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]CGP12177 from human beta2 receptor expressed in HEK Flp-In cells measured after 90 mins by microbeta scintillation counting metho...


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Dopamine receptors; D2 & D4


(Homo sapiens (Human))
BDBM50204306
PNG
(CHEMBL3897499)
Show SMILES [H][C@@]12CCC[C@@]3([H])N(CCC)CC[C@@]([H])(c4cc5ccc(cc5nc4[C@@H]1CC)C(F)(F)F)[C@]23[H] |r|
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]N-methylspiperone from human D4 receptor measured after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50204319
PNG
(CHEMBL3927917)
Show SMILES [H][C@]12CCN(C(=O)NCc3ccc(Cl)cc3)[C@]3([H])CCC[C@]([H])([C@@H](CC)C(=O)C1)[C@@]23[H] |r|
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]U69593 from KOR (unknown origin) expressed in HEKT cells measured after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50204304
PNG
(CHEMBL3954961)
Show SMILES [H][C@]12CCN(CCC)[C@]3([H])CCC[C@]([H])([C@@H](Cc4ccccc4)C(=O)C1)[C@@]23[H] |r|
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from human MOR expressed in HEK cells after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50204299
PNG
(CHEMBL3898676)
Show SMILES [H][C@]12CCN(CCC)[C@]3([H])CCC[C@]([H])([C@@H](Cc4ccc(OC)cc4)C(=O)C1)[C@@]23[H] |r|
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from human MOR expressed in HEK cells after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50204302
PNG
(CHEMBL3908975)
Show SMILES [H][C@]12CCN(CCC)[C@]3([H])CCC[C@]([H])([C@@H](CC)C(=O)C1)[C@@]23[H] |r|
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from human MOR expressed in HEK cells after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50204308
PNG
(CHEMBL3980626)
Show SMILES [H][C@]12CCN(Cc3cccs3)[C@]3([H])CCC[C@]([H])([C@@H](Cc4ccccc4)C(=O)C1)[C@@]23[H] |r|
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from human MOR expressed in HEK cells after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 7 (5-HT7)


(Homo sapiens (Human))
BDBM50204306
PNG
(CHEMBL3897499)
Show SMILES [H][C@@]12CCC[C@@]3([H])N(CCC)CC[C@@]([H])(c4cc5ccc(cc5nc4[C@@H]1CC)C(F)(F)F)[C@]23[H] |r|
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cells measured after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50204299
PNG
(CHEMBL3898676)
Show SMILES [H][C@]12CCN(CCC)[C@]3([H])CCC[C@]([H])([C@@H](Cc4ccc(OC)cc4)C(=O)C1)[C@@]23[H] |r|
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]DADLE from human DOR expressed in HEK cells measured after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (Human))
BDBM50204312
PNG
(CHEMBL3936289)
Show SMILES [H][C@]12CCN(C)[C@]3([H])CCC[C@]([H])([C@@H](Cc4ccccc4)C(=O)C1)[C@@]23[H] |r|
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]Way100635 from human 5-HT1A receptor expressed in CHO cells measured after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (Human))
BDBM50204306
PNG
(CHEMBL3897499)
Show SMILES [H][C@@]12CCC[C@@]3([H])N(CCC)CC[C@@]([H])(c4cc5ccc(cc5nc4[C@@H]1CC)C(F)(F)F)[C@]23[H] |r|
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]Way100635 from human 5-HT1A receptor expressed in CHO cells measured after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))
BDBM50204306
PNG
(CHEMBL3897499)
Show SMILES [H][C@@]12CCC[C@@]3([H])N(CCC)CC[C@@]([H])(c4cc5ccc(cc5nc4[C@@H]1CC)C(F)(F)F)[C@]23[H] |r|
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]Ketanserin from 5-HT2A receptor (unknown origin) measured after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM50204306
PNG
(CHEMBL3897499)
Show SMILES [H][C@@]12CCC[C@@]3([H])N(CCC)CC[C@@]([H])(c4cc5ccc(cc5nc4[C@@H]1CC)C(F)(F)F)[C@]23[H] |r|
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]Mesulergine from human 5-HT2C receptor expressed in Flp-IN HEK cells measured after 90 mins by microbeta scintillation counting m...


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Homo sapiens (Human))
BDBM50204306
PNG
(CHEMBL3897499)
Show SMILES [H][C@@]12CCC[C@@]3([H])N(CCC)CC[C@@]([H])(c4cc5ccc(cc5nc4[C@@H]1CC)C(F)(F)F)[C@]23[H] |r|
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Binding affinity to H2 receptor (unknown origin) expressed in HEKT cells measured after 90 mins by radioligand binding assay


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50204303
PNG
(CHEMBL3935644)
Show SMILES [H][C@@]12CCC[C@@]3([H])N(CCC)CC[C@@]([H])(CC(=O)C1)[C@]23[H] |r|
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]U69593 from KOR (unknown origin) expressed in HEKT cells measured after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50204321
PNG
(CHEMBL3904569)
Show SMILES [H][C@]12CCN(CCOC)[C@]3([H])CCC[C@]([H])([C@@H](Cc4ccccc4)C(=O)C1)[C@@]23[H] |r|
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]U69593 from KOR (unknown origin) expressed in HEKT cells measured after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50204314
PNG
(CHEMBL3981067)
Show SMILES [H][C@]12CCN(CCC)[C@]3([H])CCC[C@]([H])([C@@H](CC)[C@H](O)C1)[C@@]23[H] |r|
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from human MOR expressed in HEK cells after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1B


(Homo sapiens (Human))
BDBM50204312
PNG
(CHEMBL3936289)
Show SMILES [H][C@]12CCN(C)[C@]3([H])CCC[C@]([H])([C@@H](Cc4ccccc4)C(=O)C1)[C@@]23[H] |r|
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]5-CT from human 5-HT1B receptor expressed in HEK cells measured after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Adrenergic alpha1B


(Homo sapiens (Human))
BDBM50204306
PNG
(CHEMBL3897499)
Show SMILES [H][C@@]12CCC[C@@]3([H])N(CCC)CC[C@@]([H])(c4cc5ccc(cc5nc4[C@@H]1CC)C(F)(F)F)[C@]23[H] |r|
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]Prazosin from human Alpha1B receptor expressed in HEK-T cells measured after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM50204312
PNG
(CHEMBL3936289)
Show SMILES [H][C@]12CCN(C)[C@]3([H])CCC[C@]([H])([C@@H](Cc4ccccc4)C(=O)C1)[C@@]23[H] |r|
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Binding affinity to human M1 receptor expressed in CHO cells measured after 90 mins by radioligand binding assay


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50204298
PNG
(CHEMBL3889737)
Show SMILES [H][C@@]12CCN(CCC)[C@]3([H])CCC[C@@]([H])([C@@]13[H])[C@]1(CC)C(C2)=Nc2ccccc12 |r,c:24|
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UniChem
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PubMed
>1.00E+4n/an/an/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Displacement of [3H]U69593 from KOR (unknown origin) expressed in HEKT cells measured after 90 mins by microbeta scintillation counting method


Bioorg Med Chem Lett 26: 5689-5694 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.065
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%