128 articles for thisTarget

---

The following articles (labelled with PubMed ID or TBD) are for your review

PMID	Data	Article Title	Organization
15149697	10	Thiol-based SAHA analogues as potent histone deacetylase inhibitors.	Nagoya City University
15109664	4	Three new cyclostellettamines, which inhibit histone deacetylase, from a marine sponge of the genus Xestospongia.	The University of Tokyo
15109636	14	Stereodefined and polyunsaturated inhibitors of histone deacetylase based on (2E,4E)-5-arylpenta-2,4-dienoic acid hydroxyamides.	University College London
14643318	23	Novel histone deacetylase inhibitors: design, synthesis, enzyme inhibition, and binding mode study of SAHA-based non-hydroxamates.	Nagoya City University
14592473	35	Heterocyclic ketones as inhibitors of histone deacetylase.	Abbott Laboratories
12270175	13	Succinimide hydroxamic acids as potent inhibitors of histone deacetylase (HDAC).	Abbott Laboratories
27186676	186	Development of Purine-Based Hydroxamic Acid Derivatives: Potent Histone Deacetylase Inhibitors with Marked in Vitro and in Vivo Antitumor Activities.	West China Hospital of Sichuan University
27142751	22	Targeting epigenetic reader and eraser: Rational design, synthesis and in vitro evaluation of dimethylisoxazoles derivatives as BRD4/HDAC dual inhibitors.	China Pharmaceutical University
26996372	10	Identification of new quinic acid derivatives as histone deacetylase inhibitors by fluorescence-based cellular assay.	Sungkyunkwan University
26890116	30	Biphenyl-4-yl-acrylohydroxamic acids: Identification of a novel indolyl-substituted HDAC inhibitor with antitumor activity.	University of Milan
27060764	30	Computer-aided identification of new histone deacetylase 6 selective inhibitor with anti-sepsis activity.	Sungkyunkwan University
26814680	71	Identification of N-(6-mercaptohexyl)-3-(4-pyridyl)-1H-pyrazole-5-carboxamide and its disulfide prodrug as potent histone deacetylase inhibitors with in vitro and in vivo anti-tumor efficacy.	Shenyang Pharmaceutical University
26706171	138	Novel thiol-based histone deacetylase inhibitors bearing 3-phenyl-1H-pyrazole-5-carboxamide scaffold as surface recognition motif: Design, synthesis and SAR study.	Shenyang Pharmaceutical University
26741358	56	Design, synthesis and biological evaluation of N-phenylquinazolin-4-amine hybrids as dual inhibitors of VEGFR-2 and HDAC.	China Pharmaceutical University
26629860	58	Synthesis, biological characterization and molecular modeling insights of spirochromanes as potent HDAC inhibitors.	European Institute of Oncology
26639764	17	Synthesis and biological activity of diisothiocyanate-derived mercapturic acids.	Wroclaw University of Technology
26475519	40	Hybrids from 4-anilinoquinazoline and hydroxamic acid as dual inhibitors of vascular endothelial growth factor receptor-2 and histone deacetylase.	China Pharmaceutical University
26241876	1	Triazine as a promising scaffold for its versatile biological behavior.	Thapar University
26035239	1	Natural Product Primary Sulfonamides and Primary Sulfamates.	Griffith University
25811792	32	Discovery of Orally Available Runt-Related Transcription Factor 3 (RUNX3) Modulators for Anticancer Chemotherapy by Epigenetic Activation and Protein Stabilization.	Yonsei University
25800646	40	Macrocyclic compounds as anti-cancer agents: design and synthesis of multi-acting inhibitors against HDAC, FLT3 and JAK2.	Central South University
25113875	14	Indole-3-ethylsulfamoylphenylacrylamides: potent histone deacetylase inhibitors with anti-inflammatory activity.	Taipei Medical University
24999749	1	A potent HDAC inhibitor, 1-alaninechlamydocin, from a Tolypocladium sp. induces G2/M cell cycle arrest and apoptosis in MIA PaCa-2 cells.	University of Oklahoma
25462271	33	Development of 3-hydroxycinnamamide-based HDAC inhibitors with potent in vitro and in vivo anti-tumor activity.	Shandong University
25455492	22	Aurones as histone deacetylase inhibitors: identification of key features.	University of Geneva
25233084	247	ST7612AA1, a thioacetate-¿(¿-lactam carboxamide) derivative selected from a novel generation of oral HDAC inhibitors.	R&D Sigma-Tau Industrie Farmaceutiche Riunite
25176189	7	Design, synthesis and biological evaluation ofß-boswellic acid based HDAC inhibitors as inducers of cancer cell death.	Csir-Indian Institute of Integrative Medicine
11206439	51	Broad spectrum antiprotozoal agents that inhibit histone deacetylase: structure-activity relationships of apicidin. Part 2.	Merck Research Laboratories
11206438	48	Broad spectrum antiprotozoal agents that inhibit histone deacetylase: structure-activity relationships of apicidin. Part 1.	Merck Research Laboratories
14698179	58	Design, synthesis, and activity of HDAC inhibitors with a N-formyl hydroxylamine head group.	The Scripps Research Institute
14684344	49	(2-amino-phenyl)-amides of omega-substituted alkanoic acids as new histone deacetylase inhibitors.	Methylgene
32273215	16	Influence of side-chain changes on histone deacetylase inhibitory and cytotoxicity activities of curcuminoid derivatives.	Khon Kaen University
32247729	23	Environment-sensitive fluorescent inhibitors of histone deacetylase.	Shandong University
30660827	70	Quinolone hybrids and their anti-cancer activities: An overview.	Qilu University of Technology (Shandong Academy of Sciences)
31787463	67	Novel alkoxyamide-based histone deacetylase inhibitors reverse cisplatin resistance in chemoresistant cancer cells.	Heinrich-Heine-Universit£T D£Sseldorf
30594678	22	Histone deacetylase 8 (HDAC8) and its inhibitors with selectivity to other isoforms: An overview.	Jadavpur University
30879863	50	Design, synthesis and activity evaluation of indole-based double - Branched HDAC1 inhibitors.	Shandong University
27460171	44	Synthesis, biological evaluation and molecular modeling studies of psammaplin A and its analogs as potent histone deacetylases inhibitors and cytotoxic agents.	Shenyang Pharmaceutical University
30245394	363	HDAC as onco target: Reviewing the synthetic approaches with SAR study of their inhibitors.	Indian Csir-Central Drug Research Institute
31431326	63	Novel ?,?-unsaturated hydroxamic acid derivatives overcome cisplatin resistance.	Heinrich-Heine-University D£Sseldorf
31223439	25	Extending Cross Metathesis To Identify Selective HDAC Inhibitors: Synthesis, Biological Activities, and Modeling.	Umr Cnrs 7285
31103900	36	Thioether-based 2-aminobenzamide derivatives: Novel HDAC inhibitors with potent in vitro and in vivo antitumor activity.	Beijing University of Chemical Technology
31400938	15	Anti-tumor activity evaluation of novel tubulin and HDAC dual-targeting inhibitors.	Qingdao University
31003060	27	Design, synthesis and biological evaluation of novel thioquinazolinone-based 2-aminobenzamide derivatives as potent histone deacetylase (HDAC) inhibitors.	Beijing University of Chemical Technology
31655430	56	N-alkyl-hydroxybenzoyl anilide hydroxamates as dual inhibitors of HDAC and HSP90, downregulating IFN-? induced PD-L1 expression.	Taipei Medical University
30901208	96	Discovery of Novel Janus Kinase (JAK) and Histone Deacetylase (HDAC) Dual Inhibitors for the Treatment of Hematological Malignancies.	Shandong University
32347094	10	Discovery of Novel Fungal Lanosterol 14?-Demethylase (CYP51)/Histone Deacetylase Dual Inhibitors to Treat Azole-Resistant Candidiasis.	Second Military Medical University
31536895	27	Indole: A privileged scaffold for the design of anti-cancer agents.	Hunan University of Science and Technology
30418766	35	Kinase and Histone Deacetylase Hybrid Inhibitors for Cancer Therapy.	Qingdao University
31762274	122	Synthesis of Peptoid-Based Class I-Selective Histone Deacetylase Inhibitors with Chemosensitizing Properties.	Heinrich-Heine-Universit£T D£Sseldorf
31050421	48	Overview of Recent Strategic Advances in Medicinal Chemistry.	Shandong University
26588603	21	Can Small Chemical Modifications of Natural Pan-inhibitors Modulate the Biological Selectivity? The Case of Curcumin Prenylated Derivatives Acting as HDAC or mPGES-1 Inhibitors.	Mashhad University of Medical Sciences
26555243	45	Novel ?-Carboline/Hydroxamic Acid Hybrids Targeting Both Histone Deacetylase and DNA Display High Anticancer Activity via Regulation of the p53 Signaling Pathway.	China Pharmaceutical University
24702857	28	Search for novel histone deacetylase inhibitors. Part II: design and synthesis of novel isoferulic acid derivatives.	Xi'An Jiaotong University
24405391	2	Mutagenesis studies of the 14 Å internal cavity of histone deacetylase 1: insights toward the acetate-escape hypothesis and selective inhibitor design.	Wayne State University
24296013	3	Synthesis and anticancer activities of thieno[3,2-d]pyrimidines as novel HDAC inhibitors.	Nantong University
24119555	13	Design, synthesis and biological evaluation of di-substituted cinnamic hydroxamic acids bearing urea/thiourea unit as potent histone deacetylase inhibitors.	Central South University
24095016	28	Development of novel ferulic acid derivatives as potent histone deacetylase inhibitors.	Xi'An Jiaotong University
23820574	89	Novel N-hydroxyfurylacrylamide-based histone deacetylase (HDAC) inhibitors with branched CAP group (Part 2).	China Pharmaceutical University
23792316	40	Design, synthesis and preliminary evaluation of a series of histone deacetylase inhibitors carrying a benzodiazepine ring.	University of Florence
23768910	12	Benzofused hydroxamic acids: useful fragments for the preparation of histone deacetylase inhibitors. Part 1: hit identification.	Menarini Ricerche
23707260	4	Discovery of a small molecular compound simultaneously targeting RXR and HADC: design, synthesis, molecular docking and bioassay.	Shenyang Pharmaceutical University
23639537	9	Design, synthesis and biological evaluation of indeno[1,2-d]thiazole derivatives as potent histone deacetylase inhibitors.	Central South University
23622981	25	Dual-acting histone deacetylase-topoisomerase I inhibitors.	Georgia Institute of Technology
22877635	6	Set-up of a new series of HDAC inhibitors: the 5,11-dihydrodibenzo[b,e]azepin-6-ones as privileged structures.	Menarini Ricerche Pomezia
22435669	16	Discovery and extensive in vitro evaluations of NK-HDAC-1: a chiral histone deacetylase inhibitor as a promising lead.	Nankai University
22326398	22	Inhibitors of human histone deacetylase with potent activity against the African trypanosome Trypanosoma brucei.	London School of Hygiene and Tropical Medicine
21978679	10	4-N-Hydroxy-4-[1-(sulfonyl)piperidin-4-yl]-butyramides as HDAC inhibitors.	Menarini Ricerche Pomezia
21621883	18	Structure-based optimization of click-based histone deacetylase inhibitors.	Nankai University
21420859	7	Alkyl piperidine and piperazine hydroxamic acids as HDAC inhibitors.	Menarini Ricerche Pomezia
24900225	26	Antiproliferative and differentiating activities of a novel series of histone deacetylase inhibitors.	Menarini Ricerche
19223622	8	Novel inhibitor of Plasmodium histone deacetylase that cures P. berghei-infected mice.	Georgetown University Medical Center
21067930	8	Discovery of 1H-benzo[d][1,2,3]triazol-1-yl 3,4,5-trimethoxybenzoate as a potential antiproliferative agent by inhibiting histone deacetylase.	Nanjing University
16921367	19	Histone deacetylase inhibitors reverse gene silencing in Friedreich's ataxia.	The Scripps Research Institute
20576572	15	New aryldithiolethione derivatives as potent histone deacetylase inhibitors.	Sulfidris
20167479	3	SelSA, selenium analogs of SAHA as potent histone deacetylase inhibitors.	Pennsylvania State Hershey College of Medicine
20036560	5	Fluoroalkene modification of mercaptoacetamide-based histone deacetylase inhibitors.	Saga University
19914074	13	Antimalarial and antileishmanial activities of histone deacetylase inhibitors with triazole-linked cap group.	Georgia Institute of Technology
20017493	29	Synthesis and biological evaluation of N-hydroxyphenylacrylamides and N-hydroxypyridin-2-ylacrylamides as novel histone deacetylase inhibitors.	Congenia
19520580	17	Molecular modifications on carboxylic acid derivatives as potent histone deacetylase inhibitors: Activity and docking studies.	Hacettepe University
19534534	3	Recent advances in the development of polyamine analogues as antitumor agents.	Johns Hopkins University
19344175	3	Synthesis, biological evaluation, and molecular docking of Ugi products containing a zinc-chelating moiety as novel inhibitors of histone deacetylases.	Universita Degli Studi Del Piemonte Orientale A. Avogadro
18954984	38	Alpha-mercaptoketone based histone deacetylase inhibitors.	Kalypsys
18397827	29	Synthesis and structure-activity relationship of histone deacetylase (HDAC) inhibitors with triazole-linked cap group.	Georgia Institute of Technology
18348516	2	Polyaminohydroxamic acids and polyaminobenzamides as isoform selective histone deacetylase inhibitors.	Wayne State University
18294844	8	New sulfurated derivatives of valproic acid with enhanced histone deacetylase inhibitory activity.	Sulfidris
17904843	20	Modification of cap group in delta-lactam-based histone deacetylase (HDAC) inhibitors.	Korea Research Institute of Bioscience and Biotechnology
17827005	24	Design and synthesis of thiazole-5-hydroxamic acids as novel histone deacetylase inhibitors.	Entremed
17662606	3	Pomiferin, histone deacetylase inhibitor isolated from the fruits of Maclura pomifera.	Wonkwang University
17532630	4	Design, synthesis, and biological activity of folate receptor-targeted prodrugs of thiolate histone deacetylase inhibitors.	Nagoya City University
17307359	9	Structural requirements of HDAC inhibitors: SAHA analogs functionalized adjacent to the hydroxamic acid.	Wayne State University
17477518	15	Structure-activity relationship studies of a series of novel delta-lactam-based histone deacetylase inhibitors.	Kribb
16723227	5	Synthesis, enzymatic inhibition, and cancer cell growth inhibition of novel delta-lactam-based histone deacetylase (HDAC) inhibitors.	Korea Research Institute of Bioscience and Biotechnology
16420064	35	Aromatic sulfide inhibitors of histone deacetylase based on arylsulfinyl-2,4-hexadienoic acid hydroxyamides.	University College London
16190761	14	Alkyl-substituted polyaminohydroxamic acids: a novel class of targeted histone deacetylase inhibitors.	Wayne State University
15715470	37	Novel inhibitors of human histone deacetylases: design, synthesis, enzyme inhibition, and cancer cell growth inhibition of SAHA-based non-hydroxamates.	Nagoya City University
16107152	16	Structure-based optimization of phenylbutyrate-derived histone deacetylase inhibitors.	The Ohio State University
15456267	26	Subtype selective substrates for histone deacetylases.	Westf£Lische Wilhelms-Universit£T M£Nster
15808449	13	Mercaptoamide-based non-hydroxamic acid type histone deacetylase inhibitors.	Miikana Therapeutics
15603949	10	Identification of a potent non-hydroxamate histone deacetylase inhibitor by mechanism-based drug design.	Nagoya City University
14711316	22	Zn2+-chelating motif-tethered short-chain fatty acids as a novel class of histone deacetylase inhibitors.	The Ohio State University
14667227	8	Synthesis and biological evaluation of 3-(4-substituted-phenyl)-N-hydroxy-2-propenamides, a new class of histone deacetylase inhibitors.	In2Gen
14521422	41	N-hydroxy-3-phenyl-2-propenamides as novel inhibitors of human histone deacetylase with in vivo antitumor activity: discovery of (2E)-N-hydroxy-3-[4-[[(2-hydroxyethyl)[2-(1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2-propenamide (NVP-LAQ824).	Novartis Institute For Biomedical Research
11831887	34	Inhibitors of human histone deacetylase: synthesis and enzyme and cellular activity of straight chain hydroxamates.	TBA
10425110	16	Synthesis and histone deacetylase inhibitory activity of new benzamide derivatives.	Mitsui Pharmaceuticals
28814374	19	From bench (laboratory) to bed (hospital/home): How to explore effective natural and synthetic PAK1-blockers/longevity-promoters for cancer therapy.	Pak Research Center
29541353	18	Histone Deacetylase Inhibitors as Treatment for Targeting Multiple Components in Cancer Therapy.	Usona Institute
29456804	5	Biocompatible Boron-Containing Prodrugs of Belinostat for the Potential Treatment of Solid Tumors.	Xavier University of Louisiana
29202397	25	Design, synthesis and biological evaluation of novel 2-aminobenzamides containing dithiocarbamate moiety as histone deacetylase inhibitors and potent antitumor agents.	Beijing University of Chemical Technology
29150330	54	The structural requirements of histone deacetylase inhibitors: C4-modified SAHA analogs display dual HDAC6/HDAC8 selectivity.	Wayne State University
29567459	49	1-Aroylindoline-hydroxamic acids as anticancer agents, inhibitors of HSP90 and HDAC.	Taipei Medical University
29500131	38	Structure optimization and preliminary bioactivity evaluation of N-hydroxybenzamide-based HDAC inhibitors with Y-shaped cap.	Shandong University
29500130	152	Design, synthesis and biological evaluation of novel hydroxamic acid based histone deacetylase 6 selective inhibitors bearing phenylpyrazol scaffold as surface recognition motif.	Shenyang Pharmaceutical University
29505935	13	Indole in the target-based design of anticancer agents: A versatile scaffold with diverse mechanisms.	Mazandaran University of Medical Sciences
29787262	64	Discovery of Novel Pazopanib-Based HDAC and VEGFR Dual Inhibitors Targeting Cancer Epigenetics and Angiogenesis Simultaneously.	Shandong University
29259737	10	Novel Polyamine-Naphthalene Diimide Conjugates Targeting Histone Deacetylases and DNA for Cancer Phenotype Reprogramming.	Alma Mater Studiorum-University of Bologna
29031066	3	Serendipitous discovery of potent human head and neck squamous cell carcinoma anti-cancer molecules: A fortunate failure of a rational molecular design.	Universit£