30 articles for thisTarget

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The following articles (labelled with PubMed ID or TBD) are for your review

PMID	Data	Article Title	Organization
15055985	22	Inhibitors of farnesyltransferase: a rational approach to cancer chemotherapy?	Merck Research Laboratories
16442288	30	Hydantoin derivatives as non-peptidic inhibitors of Ras farnesyl transferase.	Keimyung University
16298128	4	Enhanced FTase activity achieved via piperazine interaction with catalytic zinc.	Schering-Plough Research Institute
16289818	90	Guiding farnesyltransferase inhibitors from an ECLiPS library to the catalytic zinc.	Pharmacopeia
16216509	18	Novel triazole based inhibitors of Ras farnesyl transferase.	Janssen Research Foundation
16202593	8	Surfing the piperazine core of tricyclic farnesyltransferase inhibitors.	Pharmacopeia
15745827	10	Novel beta-(imidazol-4-yl)-beta-amino acids: solid-phase synthesis and study of their inhibitory activity against geranylgeranyl protein transferase type I.	Janssen Research Foundation
15582430	123	Design and synthesis of o-trifluoromethylbiphenyl substituted 2-amino-nicotinonitriles as inhibitors of farnesyltransferase.	Abbott Laboratories
15501065	6	Bridgehead modification of trihalocycloheptabenzopyridine leads to a potent farnesyl protein transferase inhibitor with improved oral metabolic stability.	Schering-Plough Research Institute
15380198	46	Synthesis and biological evaluation of 1-benzyl-5-(3-biphenyl-2-yl-propyl)-1H-imidazole as novel farnesyltransferase inhibitor.	Abbott Laboratories
14711313	8	Design and synthesis of peptidomimetic protein farnesyltransferase inhibitors as anti-Trypanosoma brucei agents.	Yale University
12190309	14	Exploring the role of bromine at C(10) of (+)-4-[2-[4-(8-chloro-3,10-dibromo- 6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11(R)-yl)-1-piperidinyl]-2- oxoethyl]-1-piperidinecarboxamide (Sch-66336): the discovery of indolocycloheptapyridine inhibitors of farnesyl protein transferase.	Schering-Plough Research Institute
11754590	53	Design and synthesis of potent nonpeptidic farnesyltransferase inhibitors based on a terphenyl scaffold.	Yale University
11520202	130	Design and biological activity of (S)-4-(5-([1-(3-chlorobenzyl)-2-oxopyrrolidin-3-ylamino]methyl)imidazol-1-ylmethyl)benzonitrile, a 3-aminopyrrolidinone farnesyltransferase inhibitor with excellent cell potency.	Merck Research Laboratories
11020273	33	Discovery of (R)-7-cyano-2,3,4, 5-tetrahydro-1-(1H-imidazol-4-ylmethyl)-3- (phenylmethyl)-4-(2-thienylsulfonyl)-1H-1,4-benzodiazepine (BMS-214662), a farnesyltransferase inhibitor with potent preclinical antitumor activity.	Bristol-Myers Squibb Pharmaceutical Research Institute
10794697	13	Multivariate data analysis using D-optimal designs, partial least squares, and response surface modeling: A directional approach for the analysis of farnesyltransferase inhibitors.	RhôNe-Poulenc Rorer
10602709	43	Discovery and structure-activity relationships of imidazole-containing tetrahydrobenzodiazepine inhibitors of farnesyltransferase.	Bristol-Myers Squibb Pharmaceutical Research Institute
10508426	13	N-arylpiperazinone inhibitors of farnesyltransferase: discovery and biological activity.	Merck Research Laboratories
10411485	46	Identification of pharmacokinetically stable 3, 10-dibromo-8-chlorobenzocycloheptapyridine farnesyl protein transferase inhibitors with potent enzyme and cellular activities.	Schering-Plough Research Institute
10377218	13	Tricyclic farnesyl protein transferase inhibitors: crystallographic and calorimetric studies of structure-activity relationships.	Schering-Plough Research Institute
10212118	44	Potent, highly selective, and non-thiol inhibitors of protein geranylgeranyltransferase-I.	Yale University
9572881	4	Potent, selective, and orally bioavailable tricyclic pyridyl acetamide N-oxide inhibitors of farnesyl protein transferase with enhanced in vivo antitumor activity.	Schering-Plough Research Institute
9526562	257	Inhibitors of farnesyl protein transferase. 4-Amido, 4-carbamoyl, and 4-carboxamido derivatives of 1-(8-chloro-6,11-dihydro-5H-benzo[5,6]- cyclohepta[1,2-b]pyridin-11-yl)piperazine and 1-(3-bromo-8-chloro-6,11- dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)piperazine.	Schering-Plough Research Institute
9435898	32	Structure-activity relationship of 3-substituted N-(pyridinylacetyl)-4- (8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene )- piperidine inhibitors of farnesyl-protein transferase: design and synthesis of in vivo active antitumor compounds.	Schering-Plough Research Institute
9406600	102	Identification of novel farnesyl protein transferase inhibitors using three-dimensional database searching methods.	Schering-Plough Research Institute
9191950	20	Novel conformationally extended naphthalene-based inhibitors of farnesyltransferase.	Centre De Recherches De Vitry-Alfortville
8691464	9	Geranylgeranyl diphosphate-based inhibitors of post-translational geranylgeranylation of cellular proteins.	Università
8691462	14	2-substituted piperazines as constrained amino acids. Application to the synthesis of potent, non carboxylic acid inhibitors of farnesyltransferase.	Merck Research Laboratories
8568812	36	Development of highly potent inhibitors of Ras farnesyltransferase possessing cellular and in vivo activity.	Bristol-Myers Squibb Pharmaceutical Research Institute
8558502	17	Potent, cell active, non-thiol tetrapeptide inhibitors of farnesyltransferase.	Bristol-Myers Squibb Pharmaceutical Research Institute