The following articles (labelled with PubMed ID or TBD) are for your review
| PMID | Data | Article Title | Organization |
|---|
| 25593099 |
57 |
Development of potent dopamine-norepinephrine uptake inhibitors (DNRIs) based on a (2S,4R,5R)-2-benzhydryl-5-((4-methoxybenzyl)amino)tetrahydro-2H-pyran-4-ol molecular template. |
Wayne State University |
| 25193229 |
102 |
Alpha-ethyltryptamines as dual dopamine-serotonin releasers. |
Research Triangle Institute |
| 1271416 |
10 |
Conformationally rigid amphetamine analogs as inhibitors of monoamine uptake by brain synaptosomes. |
TBA |
| 533882 |
1 |
Synthesis of spiro[isobenzofuran-1(3H),4'-piperidines] as potential central nervous system agents. 5. Conformationally mobile analogues derived by furan ring opening. |
TBA |
| 24315194 |
18 |
Flexible and biomimetic analogs of triple uptake inhibitor 4-((((3S,6S)-6-benzhydryltetrahydro-2H-pyran-3-yl)amino)methyl)phenol: Synthesis, biological characterization, and development of a pharmacophore model. |
Wayne State University |
| 24900562 |
126 |
Azepines and piperidines with dual norepinephrine dopamine uptake inhibition and antidepressant activity. |
Astrazeneca |
| 23084899 |
102 |
4-Phenyl tetrahydroisoquinolines as dual norepinephrine and dopamine reuptake inhibitors. |
Amri |
| 22749190 |
23 |
Wake-promoting agents: search for next generation modafinil: part IV. |
Cephalon (France) |
| 21344069 |
43 |
Structure-Activity Relationships at the Monoamine Transporters for a Novel Series of Modafinil (2-[(diphenylmethyl)sulfinyl]acetamide) Analogues. |
National Institute On Drug Abuse-Intramural Research Program |
| 20527970 |
29 |
6-(3,4-dichlorophenyl)-1-[(methyloxy)methyl]-3-azabicyclo[4.1.0]heptane: a new potent and selective triple reuptake inhibitor. |
Glaxosmithkline |
| 19896846 |
44 |
Synthesis and monoamine transporter affinity of 3alpha-arylmethoxy-3beta-arylnortropanes. |
University Of New Orleans |
| 18954038 |
62 |
Characterization of thien-2-yl 1S,2R-milnacipran analogues as potent norepinephrine/serotonin transporter inhibitors for the treatment of neuropathic pain. |
Neurocrine Biosciences |
| 18774292 |
72 |
Dual DAT/sigma1 receptor ligands based on 3-(4-(3-(bis(4-fluorophenyl)amino)propyl)piperazin-1-yl)-1-phenylpropan-1-ol. |
National Institute On Drug Abuse-Intramural Research Program |
| 19038547 |
62 |
1-Naphthyl and 4-indolyl arylalkylamines as selective monoamine reuptake inhibitors. |
The State University Of New York |
| 18539031 |
126 |
Studies on the structure-activity relationship of bicifadine analogs as monoamine transporter inhibitors. |
Neurocrine Biosciences |
| 18249549 |
54 |
Further structural optimization of cis-(6-benzhydryl-piperidin-3-yl)-benzylamine and 1,4-diazabicyclo[3.3.1]nonane derivatives by introducing an exocyclic hydroxyl group: interaction with dopamine, serotonin, and norepinephrine transporters. |
Wayne State University |
| 18278854 |
20 |
Conversion of a highly selective sigma-1 receptor-ligand to sigma-2 receptor preferring ligands with anticocaine activity. |
The University Of Mississippi |
| 17489581 |
95 |
Synthesis and pharmacology of site-specific cocaine abuse treatment agents: restricted rotation analogues of methylphenidate. |
Georgia Institute Of Technology |
| 17407815 |
27 |
Tricyclic isoxazolines: identification of R226161 as a potential new antidepressant that combines potent serotonin reuptake inhibition and alpha2-adrenoceptor antagonism. |
Janssen-Cilag |
| 17267226 |
46 |
Novel piperazines: potent melanocortin-4 receptor antagonists with anxiolytic-like activity. |
Taisho Pharmaceutical |
| 17034144 |
72 |
Structure-activity relationship studies on a novel series of (S)-2beta-substituted 3alpha-[bis(4-fluoro- or 4-chlorophenyl)methoxy]tropane analogues for in vivo investigation. |
National Institute On Drug Abuse-Intramural Research Program |
| 16250647 |
71 |
2-n-Butyl-9-methyl-8-[1,2,3]triazol-2-yl-9H-purin-6-ylamine and analogues as A2A adenosine receptor antagonists. Design, synthesis, and pharmacological characterization. |
Universit£ |
| 15743177 |
43 |
Synthesis and biological evaluation of meperidine analogues at monoamine transporters. |
University Of New Orleans |
| 15916437 |
90 |
Synthesis and monoamine transporter binding properties of 3alpha-(substituted phenyl)nortropane-2beta-carboxylic acid methyl esters. Norepinephrine transporter selective compounds. |
Research Triangle Institute |
| 15537337 |
95 |
Piperidine-based nocaine/modafinil hybrid ligands as highly potent monoamine transporter inhibitors: efficient drug discovery by rational lead hybridization. |
Acenta Discovery |
| 15456254 |
60 |
Further structurally constrained analogues of cis-(6-benzhydrylpiperidin-3-yl)benzylamine with elucidation of bioactive conformation: discovery of 1,4-diazabicyclo[3.3.1]nonane derivatives and evaluation of their biological properties for the monoamine transporters. |
Wayne State University |
| 15686927 |
39 |
Synthesis and monoamine transporter affinity of new 2beta-carbomethoxy-3beta-[4-(substituted thiophenyl)]phenyltropanes: discovery of a selective SERT antagonist with picomolar potency. |
Yale University |
| 15163183 |
92 |
Synthesis, molecular modeling, and biological studies of novel piperidine-based analogues of cocaine: evidence of unfavorable interactions proximal to the 3alpha-position of the piperidine ring. |
University Of Illinois At Chicago |
| 15027858 |
35 |
Synthesis and monoamine transporter binding of 2-(diarylmethoxymethyl)-3 beta-aryltropane derivatives. |
University Of New Orleans |
| 14711303 |
115 |
Synthesis, monoamine transporter binding properties, and behavioral pharmacology of a series of 3beta-(substituted phenyl)-2beta-(3'-substituted isoxazol-5-yl)tropanes. |
Research Triangle Institute |
| 15189035 |
67 |
Structure-activity relationships at monoamine transporters for a series of N-substituted 3alpha-(bis[4-fluorophenyl]methoxy)tropanes: comparative molecular field analysis, synthesis, and pharmacological evaluation. |
National Institute On Drug Abuse-Intramural Research Program |
| 12646032 |
30 |
High affinity hydroxypiperidine analogues of 4-(2-benzhydryloxyethyl)-1-(4-fluorobenzyl)piperidine for the dopamine transporter: stereospecific interactions in vitro and in vivo. |
Wayne State University |
| 14640559 |
405 |
Syntheses and binding studies of new [(aryl)(aryloxy)methyl]piperidine derivatives and related compounds as potential antidepressant drugs with high affinity for serotonin (5-HT) and norepinephrine (NE) transporters. |
Faes Farma |
| 12825932 |
61 |
Structure-activity relationship comparison of (S)-2beta-substituted 3alpha-(bis[4-fluorophenyl]methoxy)tropanes and (R)-2beta-substituted 3beta-(3,4-dichlorophenyl)tropanes at the dopamine transporter. |
National Institute On Drug Abuse |
| 12801223 |
71 |
Dual probes for the dopamine transporter and sigma1 receptors: novel piperazinyl alkyl-bis(4'-fluorophenyl)amine analogues as potential cocaine-abuse therapeutic agents. |
Nida-Irp |
| 12747792 |
12 |
Interaction of cis-(6-benzhydrylpiperidin-3-yl)benzylamine analogues with monoamine transporters: structure-activity relationship study of structurally constrained 3,6-disubstituted piperidine analogues of (2,2-diphenylethyl)-[1-(4-fluorobenzyl)piperidin-4-ylmethyl]amine. |
Wayne State University |
| 12723962 |
69 |
Biaryl analogues of conformationally constrained tricyclic tropanes as potent and selective norepinephrine reuptake inhibitors: synthesis and evaluation of their uptake inhibition at monoamine transporter sites. |
Georgetown University Medical Center |
| 12723940 |
145 |
2002 Medicinal Chemistry Division Award address: monoamine transporters and opioid receptors. Targets for addiction therapy. |
Research Triangle Institute |
| 11960503 |
140 |
Further studies on conformationally constrained tricyclic tropane analogues and their uptake inhibition at monoamine transporter sites: synthesis of (Z)-9-(substituted arylmethylene)-7-azatricyclo[4.3.1.0(3,7)]decanes as a novel class of serotonin transporter inhibitors. |
Georgetown University Medical Center |
| 11881989 |
7 |
Synthesis and biological evaluation of 2-substituted 3beta-tolyltropane derivatives at dopamine, serotonin, and norepinephrine transporters. |
University Of New Orleans |
| 11806716 |
44 |
Expansion of structure-activity studies of piperidine analogues of 1-[2-(diphenylmethoxy)ethyl]-4-(3-phenylpropyl)piperazine (GBR 12935) compounds by altering substitutions in the N-benzyl moiety and behavioral pharmacology of selected molecules. |
Wayne State University |
| 12190324 |
15 |
Synthesis and transporter binding properties of 3beta-[4'-(phenylalkyl, -phenylalkenyl, and -phenylalkynyl)phenyl]tropane-2beta-carboxylic acid methyl esters: evidence of a remote phenyl binding domain on the dopamine transporter. |
Research Triangle Institute |
| 12109901 |
45 |
SAR studies of piperidine-based analogues of cocaine. 4. Effect of N-modification and ester replacement. |
Georgetown University Medical Center |
| 11300876 |
47 |
Structure-activity relationship studies of 4-[2-(diphenylmethoxy)ethyl]-1-benzylpiperidine derivatives and their N-analogues: evaluation of O-and N-analogues and their binding to monoamine transporters. |
Wayne State University |
| 11170654 |
72 |
Structure-activity relationships at monoamine transporters and muscarinic receptors for N-substituted-3alpha-(3'-chloro-, 4'-chloro-, and 4',4''-dichloro-substituted-diphenyl)methoxytropanes. |
National Institute On Drug Abuse-Intramural Research Program |
| 11334571 |
79 |
Pharmacological and behavioral analysis of the effects of some bivalent ligand-based monoamine reuptake inhibitors. |
Georgetown University Medical Center |
| 10737754 |
30 |
Further SAR studies of piperidine-based analogues of cocaine. 2. Potent dopamine and serotonin reuptake inhibitors. |
Georgetown University Medical Center |
| 11123996 |
21 |
Design, synthesis, and monoamine transporter binding site affinities of methoxy derivatives of indatraline. |
National Institute Of Diabetes And Digestive And Kidney Diseases |
| 10821718 |
69 |
Novel conformationally constrained tropane analogues by 6-endo-trig radical cyclization and stille coupling - switch of activity toward the serotonin and/or norepinephrine transporter. |
Georgetown University Medical Center |
| 10579846 |
68 |
Synthesis and pharmacology of site-specific cocaine abuse treatment agents: 2-substituted-6-amino-5-phenylbicyclo[2.2.2]octanes. |
Georgia Institute Of Technology |
| 10543888 |
60 |
Structure-activity relationships at the monoamine transporters and sigma receptors for a novel series of 9-[3-(cis-3, 5-dimethyl-1-piperazinyl)propyl]carbazole (rimcazole) analogues. |
National Institute On Drug Abuse-Intramural Research Program |
| 9457247 |
39 |
Synthesis and ligand binding of tropane ring analogues of paroxetine. |
Research Triangle Institute |
| 9632371 |
28 |
2beta-Substituted analogues of 4'-iodococaine: synthesis and dopamine transporter binding potencies. |
University Of Oklahoma Health Sciences Center |
| 9135033 |
36 |
Synthesis and ligand binding of nortropane derivatives: N-substituted 2beta-carbomethoxy-3beta-(4'-iodophenyl)nortropane and N-(3-iodoprop-(2E)-enyl)-2beta-carbomethoxy-3beta-(3',4'-disubstituted phenyl)nortropane. New high-affinity and selective compounds for the dopamine transporter. |
University Of Tours |
| 9111298 |
18 |
Synthesis and transporter binding properties of 2,3-diphenyltropane stereoisomers. Comparison to 3beta-phenyltropane-2beta-carboxylic acid esters. |
Research Triangle Institute |
| 9397165 |
27 |
3 Beta-(4-ethyl-3-iodophenyl)nortropane-2 beta-carboxylic acid methyl ester as a high-affinity selective ligand for the serotonin transporter. |
Research Triangle Institute |
| 8863789 |
31 |
3 alpha-(4'-substituted phenyl)tropane-2 beta-carboxylic acid methyl esters: novel ligands with high affinity and selectivity at the dopamine transporter. |
Research Triangle Institute |
| 8831768 |
65 |
Synthesis and transporter binding properties of 3 beta-(4'-alkyl-, 4'-alkenyl-, and 4'-alkynylphenyl)nortropane-2 beta-carboxylic acid methyl esters: serotonin transporter selective analogs. |
Research Triangle Institute |
| 8558525 |
60 |
N-substituted analogs of 2 beta-carbomethoxy-3 beta- (4'-iodophenyl)tropane (beta-CIT) with selective affinity to dopamine or serotonin transporters in rat forebrain. |
Research Biochemicals International |
| 8709106 |
89 |
Synthesis, ligand binding, and quantitative structure-activity relationship study of 3 beta-(4'-substituted phenyl)-2 beta-heterocyclic tropanes: evidence for an electrostatic interaction at the 2 beta-position. |
Research Triangle Institute |
| 7830281 |
237 |
Cocaine and 3 beta-(4'-substituted phenyl)tropane-2 beta-carboxylic acid ester and amide analogues. New high-affinity and selective compounds for the dopamine transporter. |
Research Triangle Institute |
| 7658431 |
18 |
Synthesis and ligand binding study of 3 beta-(4'-substituted phenyl)-2 beta-(heterocyclic)tropanes. |
Research Triangle Institute |
| 8164265 |
42 |
Secondary amine analogues of 3 beta-(4'-substituted phenyl)tropane-2 beta-carboxylic acid esters and N-norcocaine exhibit enhanced affinity for serotonin and norepinephrine transporters. |
National Institute On Drug Abuse |
| 8411004 |
48 |
3-Aryl-2-(3'-substituted-1',2',4'-oxadiazol-5'-yl)tropane analogues of cocaine: affinities at the cocaine binding site at the dopamine, serotonin, and norepinephrine transporters. |
Research Triangle Institute |
| 1619622 |
51 |
Isopropyl and phenyl esters of 3 beta-(4-substituted phenyl)tropan-2 beta-carboxylic acids. Potent and selective compounds for the dopamine transporter. |
Research Triangle Institute |
| 1976813 |
83 |
2-Phenyl-2-(1-hydroxycycloalkyl)ethylamine derivatives: synthesis and antidepressant activity. |
Wyeth-Ayerst Research |
| 2903929 |
143 |
Antihypertensive activity in a series of 1-piperazino-3-phenylindans with potent 5-HT2-antagonistic activity. |
H. Lundbeck |
| 3039136 |
328 |
Pyrroloisoquinoline antidepressants. 2. In-depth exploration of structure-activity relationships. |
TBA |
| 2999402 |
207 |
3-Phenyl-1-indanamines. Potential antidepressant activity and potent inhibition of dopamine, norepinephrine, and serotonin uptake. |
TBA |
| 6747993 |
69 |
Pyrroloisoquinoline antidepressants. Potent, enantioselective inhibition of tetrabenazine-induced ptosis and neuronal uptake of norepinephrine, dopamine, and serotonin. |
TBA |
| 6492080 |
195 |
Nontricyclic antidepressant agents derived from cis- and trans-1-amino-4-aryltetralins. |
TBA |
| 6134833 |
91 |
Neuroleptic activity and dopamine-uptake inhibition in 1-piperazino-3-phenylindans. |
TBA |
| 7452682 |
76 |
3-(4-Piperidinylalkyl)indoles, selective inhibitors of neuronal 5-hydroxytryptamine uptake. |
TBA |
| 15115403 |
48 |
Synthesis and pharmacological evaluation of 3-(3,4-dichlorophenyl)-1-indanamine derivatives as nonselective ligands for biogenic amine transporters. |
National Institute Of Diabetes And Digestive And Kidney Diseases |
| 15149693 |
56 |
The effect of 6-substituted-4',4"-difluorobenztropines on monoamine transporters and the muscarinic M1 receptor. |
National Institute On Drug Abuse-Intramural Research Program |
| 12699762 |
27 |
Design, synthesis, and activity of novel cis- and trans-3,6-disubstituted pyran biomimetics of 3,6-disubstituted piperidine as potential ligands for the dopamine transporter. |
Wayne State University |
| 14505672 |
78 |
Synthesis and pharmacological evaluation of (Z)-9-(heteroarylmethylene)-7-azatricyclo[4.3.1.0(3,7)]decanes: thiophene analogues as potent norepinephrine transporter inhibitors. |
Georgetown University Medical Center |
| 11909701 |
35 |
Thiophene derivatives: a new series of potent norepinephrine and serotonin reuptake inhibitors. |
Georgetown University Medical Center |
| 12067559 |
34 |
Discovery of substituted 3,4-diphenyl-thiazoles as a novel class of monoamine transporter inhibitors through 3-D pharmacophore search using a new pharmacophore model derived from mazindol. |
University Of Michigan |
| 11354356 |
42 |
Pharmacophore-based discovery of 3,4-disubstituted pyrrolidines as a novel class of monoamine transporter inhibitors. |
Georgetown University Medical Center |
| 11720867 |
24 |
[3-cis-3,5-Dimethyl-(1-piperazinyl)alkyl]-bis-(4'-fluorophenyl)amine analogues as novel probes for the dopamine transporter. |
National Institute On Drug Abuse-Intramural Research Program |
| 11527726 |
15 |
Rational design and synthesis of novel 2,5-disubstituted cis- and trans-piperidine derivatives exhibiting differential activity for the dopamine transporter. |
Wayne State University |
| 11514143 |
71 |
Sar studies of piperidine-based analogues of cocaine. Part 3: oxadiazoles. |
Georgetown University Medical Center |
| 11078197 |
65 |
3alpha-(4-Substituted phenyl)nortropane-2beta-carboxylic acid methyl esters show selective binding at the norepinephrine transporter. |
Research Triangle Institute |
| 10937724 |
56 |
Synthesis and biological evaluation of 1-azabicyclo-[3.2.1]octanes: new dopamine transporter inhibitors. |
Georgetown University Medical Center |
| 10888328 |
17 |
An enantioselective synthesis and biobehavioral evaluation of 7-fluoro-3-(p-fluorophenyl)-2-propyltropanes. |
Georgetown University Medical Center |
| 9871604 |
114 |
Synthesis of a potent wide-spectrum serotonin-, norepinephrine-, dopamine-reuptake inhibitor (SNDRI) and a species-selective dopamine-reuptake inhibitor based on the gamma-amino alcohol functional group. |
Hong Kong University Of Science And Technology |
| 9934496 |
27 |
Synthesis and transporter binding properties of (R)-2 beta, 3 beta- and (R)-2 alpha, 3 alpha-diaryltropanes. |
Research Triangle Institute |
| | 28 |
Synthesis and evaluation of novel-N-[2-(bis-aryl-methoxy)ethyl-N-aralkyl-,-alkanediamines as potent and selective dopamine reuptake inhibitors: Seco analogs of GBR12935 and GBR12909 |
TBA |
| 22341942 |
18 |
Wake-promoting agents: search for next generation modafinil: part II. |
Cephalon |
| 22264475 |
10 |
Wake-promoting agents: search for next generation modafinil: part I. |
Cephalon |
| 22055716 |
45 |
Further structure-activity relationship studies on 8-substituted-3-[2-(diarylmethoxyethylidenyl)]-8-azabicyclo[3.2.1]octane derivatives at monoamine transporters. |
University Of New Orleans |
| 21093273 |
154 |
Synthesis and pharmacological evaluation of 4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalenyl amines as triple reuptake inhibitors. |
Sepracor |
| 20980153 |
83 |
Synthesis and structure-activity studies of benzyl ester meperidine and normeperidine derivatives as selective serotonin transporter ligands. |
University Of New Orleans |
| 20945906 |
33 |
Diaryldiamines with dual inhibition of the histamine H(3) receptor and the norepinephrine transporter and the efficacy of 4-(3-(methylamino)-1-phenylpropyl)-6-(2-(pyrrolidin-1-yl)ethoxy)naphthalen-1-ol in pain. |
Abbott Laboratories |
| 20672825 |
67 |
Structure-activity relationships for a novel series of citalopram (1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile) analogues at monoamine transporters. |
National Institute On Drug Abuse-Intramural Research Program |
| 20022503 |
15 |
Synthesis and antidepressant activity of optical isomers of 2-(4-benzylpiperazin-1-yl)-1-(5-chloro-6-methoxynaphthalen-2-yl) propan-1-ol (SIPI5056). |
Institute Of Pharmaceutical Industry |
| 20170186 |
49 |
1-(Aryl)-6-[alkoxyalkyl]-3-azabicyclo[3.1.0]hexanes and 6-(aryl)-6-[alkoxyalkyl]-3-azabicyclo[3.1.0]hexanes: a new series of potent and selective triple reuptake inhibitors. |
Glaxosmithkline |
| 19640707 |
12 |
Design and synthesis of (2R,3S)-iodoreboxetine analogues for SPECT imaging of the noradrenaline transporter. |
University Of Glasgow |
| 19616432 |
176 |
Design, synthesis and evaluation of N-[(3S)-pyrrolidin-3-yl]benzamides as selective noradrenaline reuptake inhibitors: CNS penetration in a more polar template. |
Pfizer |
| | 18 |
N-Phthalimidoalkyl derivatives of 2β-carbomethoxy-3β-(4′-iodophenyl)tropane (β-CIT): Brain monoamine transporter affinity |
TBA |
| 18595716 |
142 |
Identification of a butyrophenone analog as a potential atypical antipsychotic agent: 4-[4-(4-chlorophenyl)-1,4-diazepan-1-yl]-1-(4-fluorophenyl)butan-1-one. |
Florida A&M University |
| 18557608 |
108 |
Structure-activity relationships of the cycloalkanol ethylamine scaffold: discovery of selective norepinephrine reuptake inhibitors. |
Wyeth Research |
| 17658253 |
23 |
New fluoro-diphenylchalcogen derivatives to explore the serotonin transporter by PET. |
University Of Tours |
| 17350257 |
54 |
Synthesis of enantiomerically pure milnacipran analogs and inhibition of dopamine, serotonin, and norepinephrine transporters. |
University Of Oslo |
| 17234422 |
118 |
Structure-activity relationships of novel piperazines as antagonists for the melanocortin-4 receptor. |
Taisho Pharmaceutical |
| 17181165 |
2 |
Arylpiperazinylalkylpyridazinones and analogues as potent and orally active antinociceptive agents: synthesis and studies on mechanism of action. |
Dipartimento Di Scienze Farmaceutiche |
| 17095215 |
25 |
Development of SPECT imaging agents for the norepinephrine transporters: [123I]INER. |
Institute For Degenerative Diseases |
| 16908151 |
24 |
Synthesis and monoamine transporter affinity of 2beta-carbomethoxy-3beta-(4'-p-substituted phenyl)-piperidine analogs of cocaine. |
Yale University |
| 16821783 |
60 |
Further structural exploration of trisubstituted asymmetric pyran derivatives (2S,4R,5R)-2-benzhydryl-5-benzylamino-tetrahydropyran-4-ol and their corresponding disubstituted (3S,6S) pyran derivatives: a proposed pharmacophore model for high-affinity interaction with the dopamine, serotonin, and no |
Wayne State University |
| 16335921 |
99 |
Further structure-activity relationship studies of piperidine-based monoamine transporter inhibitors: effects of piperidine ring stereochemistry on potency. Identification of norepinephrine transporter selective ligands and broad-spectrum transporter inhibitors. |
University Of Illinois At Chicago |
| 16236497 |
48 |
Synthesis and monoamine transporter affinity of new 2beta-carbomethoxy-3beta-[aryl or heteroaryl]phenyltropanes. |
Yale University |
| 16033275 |
7 |
Discovery of novel trisubstituted asymmetric derivatives of (2S,4R,5R)-2-benzhydryl-5-benzylaminotetrahydropyran-4-ol, exhibiting high affinity for serotonin and norepinephrine transporters in a stereospecific manner. |
Wayne State University |
| 15863297 |
57 |
Discovery of novel conformationally constrained tropane-based biaryl and arylacetylene ligands as potent and selective norepinephrine transporter inhibitors and potential antidepressants. |
Acenta Discovery |
| 15771448 |
187 |
Discovery of a new series of centrally active tricyclic isoxazoles combining serotonin (5-HT) reuptake inhibition with alpha2-adrenoceptor blocking activity. |
Janssen-Cilag |
| 15771415 |
155 |
Discovery of new tetracyclic tetrahydrofuran derivatives as potential broad-spectrum psychotropic agents. |
Johnson & Johnson Pharmaceutical Research & Development |
| 15482938 |
45 |
Synthesis and amine transporter affinities of novel phenyltropane derivatives as potential positron emission tomography (PET) imaging agents. |
Harvard Medical School |
| 15080991 |
38 |
Synthesis and monoamine transporter affinity of 3'-analogs of 2-beta-carbomethoxy-3-beta-(4'-iodophenyl)tropane (beta-CIT). |
Yale School Of Medicine |
| 12672246 |
68 |
Structure-activity relationship studies of highly selective inhibitors of the dopamine transporter: N-benzylpiperidine analogues of 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine. |
Niddk |
| 12109911 |
47 |
Synthesis and pharmacological testing of 1,2,3,4,10,14b-hexahydro-6-methoxy-2-methyldibenzo[c,f]pyrazino[1,2-a]azepin and its enantiomers in comparison with the two antidepressants mianserin and mirtazapine. |
University Center For Pharmacy |
| 11965364 |
36 |
Enantioselective synthesis of S-(+)-2beta-carboalkoxy-3alpha-[bis(4-fluorophenyl)methoxy]tropanes as novel probes for the dopamine transporter. |
National Institute On Drug Abuse-Intramural Research Program |
| 11881994 |
42 |
Substituted diphenyl sulfides as selective serotonin transporter ligands: synthesis and in vitro evaluation. |
University Of Tours |
| 11714608 |
30 |
Synthesis and biological evaluation of a series of novel N- or O-fluoroalkyl derivatives of tropane: potential positron emission tomography (PET) imaging agents for the dopamine transporter. |
Alcohol And Drug Abuse Research Center |
| 11334561 |
63 |
Synthesis of 2beta-acyl-3beta-(substituted naphthyl)-8-azabicyclo[3.2.1]octanes and their binding affinities at dopamine and serotonin transport sites. |
State University Of New York |
| 11133081 |
33 |
A convenient procedure for the synthesis of nonsymmetrical bivalent selective serotonin reuptake inhibitors using polymer-supported reagents. |
Georgetown University Medical Center |
| 10969967 |
34 |
Synthesis and monoamine transporter affinity of 2beta-carbomethoxy-3beta-(2''-, 3''- or 4''-substituted) biphenyltropanes. |
Yale University |
| 10669562 |
29 |
Discovery of a novel dopamine transporter inhibitor, 4-hydroxy-1-methyl-4-(4-methylphenyl)-3-piperidyl 4-methylphenyl ketone, as a potential cocaine antagonist through 3D-database pharmacophore searching. Molecular modeling, structure-activity relationships, and behavioral pharmacological studies. |
Georgetown University Medical Center |
| 9526575 |
14 |
Synthesis and pharmacological evaluation of ring-methylated derivatives of 3,4-(methylenedioxy)amphetamine (MDA). |
Purdue University |
| 9357518 |
74 |
Novel tacrine analogues for potential use against Alzheimer's disease: potent and selective acetylcholinesterase inhibitors and 5-HT uptake inhibitors. |
University Of Strathclyde |
| 8691453 |
42 |
Synthesis of 3 beta-aryl-8-azabicyclo[3.2.1]octanes with high binding affinities and selectivities for the serotonin transporter site. |
State University Of New York |
| 7562944 |
16 |
In vivo and in vitro studies on the neurotoxic potential of 6-hydroxydopamine analogs. |
University Of Oklahoma |
| 6716399 |
2 |
Synthesis and central nervous system properties of 2-[(alkoxycarbonyl)amino]-4(5)-phenyl-2-imidazolines. |
TBA |
| 6458703 |
72 |
Synthesis of pyridylallylamines related to zimelidine and their inhibition of neuronal monoamine uptake. |
TBA |
| 11262089 |
213 |
Potential antidepressants displayed combined alpha(2)-adrenoceptor antagonist and monoamine uptake inhibitor properties. |
Institut De Recherches Servier |
| 3735309 |
50 |
Selective monoamine oxidase inhibitors. 3. Cyclic compounds related to 4-aminophenethylamine. Preparation and neuron-selective action of some 5-(2-aminoethyl)-2,3-dihydroindoles. |
TBA |
| 28731336 |
151 |
Triple Reuptake Inhibitors as Potential Therapeutics for Depression and Other Disorders: Design Paradigm and Developmental Challenges. |
Biocon Bristol-Myers Squibb R&D Centre |
| 2985785 |
3 |
Orally active and potent inhibitors of gamma-aminobutyric acid uptake. |
TBA |
| 16675639 |
28 |
Desvenlafaxine succinate: A new serotonin and norepinephrine reuptake inhibitor. |
Wyeth Research |
| 17602602 |
117 |
Synthesis, monoamine transporter binding, properties, and functional monoamine uptake activity of 3beta-[4-methylphenyl and 4-chlorophenyl]-2 beta-[5-(substituted phenyl)thiazol-2-yl]tropanes. |
Research Triangle Institute |
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