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Compounds Sorted by Binding Targets per Compound

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Compounds Sorted Alphabetically

Compound Name (alphabetical)	Binding Targets	Enz. Inhib. Data							ITC Data	Alternate Compound Names
		Ki	IC50	Kd	EC50	Koff	Kon	Other
BDBM10304	Acetylcholinesterase Acyl-CoA: cholesterol acyltransferase (ACAT) Carboxylesterase 1 Caspase-3 Cholinesterase Chorismate mutase (MTB CM) Factor XIIa Human rhinovirus A protease Transthyretin	6	3	0	0	0	0	0	0	1-methyl-2,3-dihydro-1H-indole-2,3-dione CHEMBL60569 Isatin analog 8 N‐methylindol‐2,3‐dione (Compound 2)
BDBM108110	Coagulation factor X Coagulation factor XI Complement C1s Factor XIIa Plasma kallikrein Plasminogen Tissue-type plasminogen activator Transcription initiation factor IIA Vitamin K-dependent protein C	10	0	0	0	0	0	0	0	US8598206, Table 6, 19
BDBM108115	Coagulation factor X Coagulation factor XI Complement C1r subcomponent Complement C1s Factor XIIa Plasma kallikrein Plasminogen Transcription initiation factor IIA Vitamin K-dependent protein C	10	0	0	0	0	0	0	0	US8598206, Table 6, 24
BDBM10844	Cyclin-Dependent Kinase 1 (CDK1) Cyclin-Dependent Kinase 5 (CDK5) Dual specificty protein kinase CLK1 Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A Glycogen Synthase Kinase-3, beta Glycogen synthase kinase-3 beta NF-kappa-beta-inducing kinase (NF-kB) cAMP-Dependent Protein Kinase (PKA) cGMP-Dependent Protein Kinase	0	10	0	0	0	0	0	0	4-(1H-indol-3-yl)pyrimidin-2-amine Meridianin G
BDBM11337	Carbonic Anhydrase IV Carbonic anhydrase 1 Carbonic anhydrase 2 Collagenase Collagenase (ChC) Matrix Metalloproteinase-8 (MMP-8) Matrix metalloproteinase 12 Matrix metalloproteinase-1 (MMP1) Stromelysin-1	11	2	0	0	0	0	0	0	2-[benzyl(4-methoxybenzene)sulfonamido]-N-hydroxypropanamide CHEMBL316169 Hydroxamate 18
BDBM11611	β-Carbonic anhydrase 2 (CA 2) β-Carbonic anhydrase 3 (CA 3) Astrosclerin-3 Carbonic Anhydrase (mtCA 1) Carbonic Anhydrase III Carbonic Anhydrase IV Carbonic anhydrase 1 Carbonic anhydrase 2 Carbonic anhydrase 9	15	0	0	0	0	0	0	0	β-CA inhibitor, 10 4-Amino-3,5-dibromobenzenesulfonamide 4-amino-3,5-dibromobenzene-1-sulfonamide CHEMBL306195 halogenosulfanilamide deriv. 12
BDBM119122	MurA (E. coli) MurB (E. coli) MurB (S. aureus) MurC MurC (S. aureus) MurD MurD (S. aureus) MurE MurE (E. coli)	0	9	0	0	0	0	0	0	MurA/B/C/D/E inhibitor (compound 67)
BDBM127657	High affinity nerve growth factor receptor JAK1 (aa 866-1154) JAK2 (aa 808-1132) JAK3 (aa 781-1124) Non-receptor tyrosine-protein kinase TYK2 Tyk2 Tyrosine-protein kinase JAK1 Tyrosine-protein kinase JAK2 Tyrosine-protein kinase JAK3	0	18	0	0	0	0	0	0	US8791123, 30 US9782415, Example 30 US9796724, Example 30
BDBM127679	High affinity nerve growth factor receptor JAK1 (aa 866-1154) JAK2 (aa 808-1132) JAK3 (aa 781-1124) Non-receptor tyrosine-protein kinase TYK2 Tyk2 Tyrosine-protein kinase JAK1 Tyrosine-protein kinase JAK2 Tyrosine-protein kinase JAK3	0	18	0	0	0	0	0	0	US8791123, 52 US9782415, Example 52 US9796724, Example 52
BDBM127718	High affinity nerve growth factor receptor JAK1 (aa 866-1154) JAK2 (aa 808-1132) JAK3 (aa 781-1124) Non-receptor tyrosine-protein kinase TYK2 Tyk2 Tyrosine-protein kinase JAK1 Tyrosine-protein kinase JAK2 Tyrosine-protein kinase JAK3	0	18	0	0	0	0	0	0	US8791123, 91 US9782415, Example 91 US9796724, Example 91
BDBM127720	High affinity nerve growth factor receptor JAK1 (aa 866-1154) JAK2 (aa 808-1132) JAK3 (aa 781-1124) Non-receptor tyrosine-protein kinase TYK2 Tyk2 Tyrosine-protein kinase JAK1 Tyrosine-protein kinase JAK2 Tyrosine-protein kinase JAK3	0	18	0	0	0	0	0	0	US8791123, 93 US9782415, Example 93 US9796724, Example 93
BDBM127725	High affinity nerve growth factor receptor JAK1 (aa 866-1154) JAK2 (aa 808-1132) JAK3 (aa 781-1124) Non-receptor tyrosine-protein kinase TYK2 Tyk2 Tyrosine-protein kinase JAK1 Tyrosine-protein kinase JAK2 Tyrosine-protein kinase JAK3	0	18	0	0	0	0	0	0	US8791123, 98 US9782415, Example 98 US9796724, Example 98
BDBM127733	High affinity nerve growth factor receptor JAK1 (aa 866-1154) JAK2 (aa 808-1132) JAK3 (aa 781-1124) Non-receptor tyrosine-protein kinase TYK2 Tyk2 Tyrosine-protein kinase JAK1 Tyrosine-protein kinase JAK2 Tyrosine-protein kinase JAK3	0	18	0	0	0	0	0	0	US8791123, 106 US9782415, Example 106 US9796724, Example 106
BDBM127741	High affinity nerve growth factor receptor JAK1 (aa 866-1154) JAK2 (aa 808-1132) JAK3 (aa 781-1124) Non-receptor tyrosine-protein kinase TYK2 Tyk2 Tyrosine-protein kinase JAK1 Tyrosine-protein kinase JAK2 Tyrosine-protein kinase JAK3	0	18	0	0	0	0	0	0	US8791123, 114 US9782415, Example 114 US9796724, Example 114
BDBM127750	High affinity nerve growth factor receptor JAK1 (aa 866-1154) JAK2 (aa 808-1132) JAK3 (aa 781-1124) Non-receptor tyrosine-protein kinase TYK2 Tyk2 Tyrosine-protein kinase JAK1 Tyrosine-protein kinase JAK2 Tyrosine-protein kinase JAK3	0	18	0	0	0	0	0	0	US8791123, 123 US9782415, Example 123 US9796724, Example 123
BDBM127751	High affinity nerve growth factor receptor JAK1 (aa 866-1154) JAK2 (aa 808-1132) JAK3 (aa 781-1124) Non-receptor tyrosine-protein kinase TYK2 Tyk2 Tyrosine-protein kinase JAK1 Tyrosine-protein kinase JAK2 Tyrosine-protein kinase JAK3	0	18	0	0	0	0	0	0	US8791123, 124 US9782415, Example 124 US9796724, Example 124
BDBM127767	High affinity nerve growth factor receptor JAK1 (aa 866-1154) JAK2 (aa 808-1132) JAK3 (aa 781-1124) Non-receptor tyrosine-protein kinase TYK2 Tyk2 Tyrosine-protein kinase JAK1 Tyrosine-protein kinase JAK2 Tyrosine-protein kinase JAK3	0	18	0	0	0	0	0	0	US8791123, 140 US9782415, Example 140 US9796724, Example 140
BDBM127817	High affinity nerve growth factor receptor JAK1 (aa 866-1154) JAK2 (aa 808-1132) JAK3 (aa 781-1124) Non-receptor tyrosine-protein kinase TYK2 Tyk2 Tyrosine-protein kinase JAK1 Tyrosine-protein kinase JAK2 Tyrosine-protein kinase JAK3	0	18	0	0	0	0	0	0	US8791123, 190 US9782415, Example 190 US9796724, Example 190
BDBM127821	High affinity nerve growth factor receptor JAK1 (aa 866-1154) JAK2 (aa 808-1132) JAK3 (aa 781-1124) Non-receptor tyrosine-protein kinase TYK2 Tyk2 Tyrosine-protein kinase JAK1 Tyrosine-protein kinase JAK2 Tyrosine-protein kinase JAK3	0	22	0	0	0	0	0	0	US8791123, 194 US9782415, Example 194 US9796724, Example 194
BDBM13080	ADAM17 Collagenase Matrix Metalloproteinase-8 (MMP-8) Matrix metalloproteinase-1 (MMP1) Matrix metalloproteinase-12 (MMP12) Matrix metalloproteinase-14 (MMP14) Matrix metalloproteinase-7 (MMP7) Meprin A subunit beta Stromelysin-1	8	13	0	0	0	0	0	0	CGS 27023A Analog 3 N-hydroxy-2-[(4-methoxybenzene)(2-methylpropyl)sulfonamido]acetamide
BDBM130909	BDNF/NT-3 growth factors receptor Hepatocyte growth factor receptor High affinity nerve growth factor receptor Insulin receptor Insulin-like growth factor I receptor NT-3 growth factor receptor Proto-oncogene tyrosine-protein kinase ROS Proto-oncogene tyrosine-protein kinase receptor Ret Serine/threonine-protein kinase receptor R3	0	9	0	0	0	0	0	0	US8822500, Stauro- sporine
BDBM135812	3',5'-cyclic phosphodiesterase (PDE4D) Lipopolysaccharide-induced tumor necrosis factor-alpha factor Phosphodiesterase 4 and 5 (PDE4 and PDE5) Tumor necrosis factor cAMP-specific 3',5'-cyclic phosphodiesterase 4B cAMP-specific 3',5'-cyclic phosphodiesterase 4B (PDE4B2) cAMP-specific 3',5'-cyclic phosphodiesterase 4D phosphodiesterase 4B2 phosphodiesterase 4D	0	10	0	0	0	0	0	0	US10085990, Example 30 US8853226, 30 US9393245, 30
BDBM135813	3',5'-cyclic phosphodiesterase (PDE4D) Lipopolysaccharide-induced tumor necrosis factor-alpha factor Phosphodiesterase 4 and 5 (PDE4 and PDE5) Tumor necrosis factor cAMP-specific 3',5'-cyclic phosphodiesterase 4B cAMP-specific 3',5'-cyclic phosphodiesterase 4B (PDE4B2) cAMP-specific 3',5'-cyclic phosphodiesterase 4D phosphodiesterase 4B2 phosphodiesterase 4D	0	10	0	0	0	0	0	0	US10085990, Example 32 US8853226, 32 US9393245, 32
BDBM135814	3',5'-cyclic phosphodiesterase (PDE4D) Lipopolysaccharide-induced tumor necrosis factor-alpha factor Phosphodiesterase 4 and 5 (PDE4 and PDE5) Tumor necrosis factor cAMP-specific 3',5'-cyclic phosphodiesterase 4B cAMP-specific 3',5'-cyclic phosphodiesterase 4B (PDE4B2) cAMP-specific 3',5'-cyclic phosphodiesterase 4D phosphodiesterase 4B2 phosphodiesterase 4D	0	10	0	0	0	0	0	0	US10085990, Example 33 US8853226, 33 US9393245, 33
BDBM135815	3',5'-cyclic phosphodiesterase (PDE4D) Lipopolysaccharide-induced tumor necrosis factor-alpha factor Phosphodiesterase 4 and 5 (PDE4 and PDE5) Tumor necrosis factor cAMP-specific 3',5'-cyclic phosphodiesterase 4B cAMP-specific 3',5'-cyclic phosphodiesterase 4B (PDE4B2) cAMP-specific 3',5'-cyclic phosphodiesterase 4D phosphodiesterase 4B2 phosphodiesterase 4D	0	10	0	0	0	0	0	0	US10085990, Example 51 US8853226, 51 US9393245, 51
BDBM135816	3',5'-cyclic phosphodiesterase (PDE4D) Lipopolysaccharide-induced tumor necrosis factor-alpha factor Phosphodiesterase 4 and 5 (PDE4 and PDE5) Tumor necrosis factor cAMP-specific 3',5'-cyclic phosphodiesterase 4B cAMP-specific 3',5'-cyclic phosphodiesterase 4B (PDE4B2) cAMP-specific 3',5'-cyclic phosphodiesterase 4D phosphodiesterase 4B2 phosphodiesterase 4D	0	10	0	0	0	0	0	0	US10085990, Example 54 US8853226, 54 US9393245, 54
BDBM135817	3',5'-cyclic phosphodiesterase (PDE4D) Lipopolysaccharide-induced tumor necrosis factor-alpha factor Phosphodiesterase 4 and 5 (PDE4 and PDE5) Tumor necrosis factor cAMP-specific 3',5'-cyclic phosphodiesterase 4B cAMP-specific 3',5'-cyclic phosphodiesterase 4B (PDE4B2) cAMP-specific 3',5'-cyclic phosphodiesterase 4D phosphodiesterase 4B2 phosphodiesterase 4D	0	10	0	0	0	0	0	0	US10085990, Example 84 US8853226, 84 US9393245, 84
BDBM135818	3',5'-cyclic phosphodiesterase (PDE4D) Lipopolysaccharide-induced tumor necrosis factor-alpha factor Phosphodiesterase 4 and 5 (PDE4 and PDE5) Tumor necrosis factor cAMP-specific 3',5'-cyclic phosphodiesterase 4B cAMP-specific 3',5'-cyclic phosphodiesterase 4B (PDE4B2) cAMP-specific 3',5'-cyclic phosphodiesterase 4D phosphodiesterase 4B2 phosphodiesterase 4D	0	10	0	0	0	0	0	0	US10085990, Example 92 US8853226, 92 US9393245, 92
BDBM135820	3',5'-cyclic phosphodiesterase (PDE4D) Lipopolysaccharide-induced tumor necrosis factor-alpha factor Phosphodiesterase 4 and 5 (PDE4 and PDE5) Tumor necrosis factor cAMP-specific 3',5'-cyclic phosphodiesterase 4B cAMP-specific 3',5'-cyclic phosphodiesterase 4B (PDE4B2) cAMP-specific 3',5'-cyclic phosphodiesterase 4D phosphodiesterase 4B2 phosphodiesterase 4D	0	10	0	0	0	0	0	0	US10085990, Example 115 US8853226, 115 US9393245, 115
BDBM135821	3',5'-cyclic phosphodiesterase (PDE4D) Lipopolysaccharide-induced tumor necrosis factor-alpha factor Phosphodiesterase 4 and 5 (PDE4 and PDE5) Tumor necrosis factor cAMP-specific 3',5'-cyclic phosphodiesterase 4B cAMP-specific 3',5'-cyclic phosphodiesterase 4B (PDE4B2) cAMP-specific 3',5'-cyclic phosphodiesterase 4D phosphodiesterase 4B2 phosphodiesterase 4D	0	10	0	0	0	0	0	0	US10085990, Example 118 US8853226, 118 US9393245, 118
BDBM135824	3',5'-cyclic phosphodiesterase (PDE4D) Lipopolysaccharide-induced tumor necrosis factor-alpha factor Phosphodiesterase 4 and 5 (PDE4 and PDE5) Tumor necrosis factor cAMP-specific 3',5'-cyclic phosphodiesterase 4B cAMP-specific 3',5'-cyclic phosphodiesterase 4B (PDE4B2) cAMP-specific 3',5'-cyclic phosphodiesterase 4D phosphodiesterase 4B2 phosphodiesterase 4D	0	10	0	0	0	0	0	0	US10085990, Example 127 US8853226, 127 US9393245, 127
BDBM13814	Protein-Tyrosine Phosphatase 1B (PTP1B) Protein-Tyrosine Phosphatase 1B (PTP1B) Mutant (G117E) Protein-Tyrosine Phosphatase 1B (PTP1B) Mutant (L119V) Protein-Tyrosine Phosphatase 1B (PTP1B) Mutant (M114V) Protein-Tyrosine Phosphatase 1B (PTP1B) Mutant (V113I) Protein-Tyrosine Phosphatase 1B (PTP1B) Mutant (V113L/M114V) Protein-tyrosine phosphatase 1B T-Cell Protein-Tyrosine Phosphatase (TCPTP) Mutant (V121L) Tyrosine-protein phosphatase non-receptor type 2	0	10	0	0	0	0	0	0	({4-[(4E)-2-(1H-1,2,3-benzotriazol-1-yl)-2-[4-(methoxycarbonyl)phenyl]-5-phenylpent-4-en-1-yl]phenyl}difluoromethyl)phosphonic acid benzotriazole phenyldifluoromethylphosphonic acid compound 1
BDBM14142	Coagulation factor X Hepsin Plasminogen Thrombin and coagulation factor X Tissue-type plasminogen activator Trypsin Trypsin-1 Urokinase (uPA) Mutant (S190A) Urokinase-type plasminogen activator	14	0	0	0	0	0	0	0	2-{5-[amino(iminiumyl)methyl]-1H-indol-2-yl}-6-phenylbenzen-1-olate 3-{5-[AMINO(IMINIO)METHYL]-1H-INDOL-2-YL}-1,1-BIPHENYL-2-OLATE) APC-8696 CA-04 CRA-8696
BDBM14152	Coagulation factor X Hepsin Plasminogen Thrombin and coagulation factor X Tissue-type plasminogen activator Trypsin Trypsin-1 Urokinase (uPA) Mutant (S190A) Urokinase-type plasminogen activator	14	0	0	0	0	0	0	0	6-CHLORO-2-(2-HYDROXY-BIPHENYL-3-YL)-1H-INDOLE-5-CARBOXAMIDINE APC-10302 CA-14 CRA-10302 {amino[6-chloro-2-(2-hydroxy-3-phenylphenyl)-1H-indol-5-yl]methylidene}azanium
BDBM14320	Beta-secretase 1 Coagulation factor III/Factor VIIa (fVIIa) Nitric oxide synthase, brain Nitric oxide synthase, endothelial Nitric oxide synthase, inducible Trypsin Tryptase Tyrosine-protein kinase TEC Urokinase-type plasminogen activator	4	4	1	0	0	0	1	0	1-amino-isoquinoline CHEMBL62083 Fragment 17 fragment 1 (J. med. chem.,50,1116) isoquinolin-1-amine
BDBM14333	Coagulation factor X Plasminogen Thrombin and coagulation factor X Tissue-type plasminogen activator Trypsin Trypsin-1 Tryptase Urokinase (uPA) Mutant (S190A) Urokinase-type plasminogen activator	12	0	0	0	0	0	0	0	2-{5-[amino(iminiumyl)methyl]-6-fluoro-1H-1,3-benzodiazol-2-yl}-6-phenylbenzen-1-olate CA-09 CRA-10818
BDBM14350	Coagulation factor X Hepsin Plasminogen Thrombin and coagulation factor X Tissue-type plasminogen activator Trypsin-1 Tryptase Urokinase (uPA) Mutant (S190A) Urokinase-type plasminogen activator	10	0	0	0	0	0	0	0	2-{5-[amino(iminiumyl)methyl]-6-fluoro-1H-1,3-benzodiazol-2-yl}-6-{[(1S,2S)-2-methylcyclohexyl]oxy}benzen-1-olate CA-11 CRA-11092
BDBM14480	Coagulation factor X Hepsin Plasminogen Thrombin and coagulation factor X Tissue-type plasminogen activator Trypsin-1 Tryptase Urokinase (uPA) Mutant (S190A) Urokinase-type plasminogen activator	10	0	0	0	0	0	0	0	CA-22 [amino({4-[(3-hydroxynaphthalene-2-)amido]phenyl}amino)methylidene]azanium
BDBM14714	Coagulation factor VII Coagulation factor X Plasma kallikrein Plasminogen Thrombin and coagulation factor X Tissue-type plasminogen activator Trypsin Urokinase-type plasminogen activator Vitamin K-dependent protein C	10	0	0	0	0	0	0	0	(2R)-N-[(3-aminobenzene)sulfonyl]-2-[(4-carbamimidoyl-3-hydroxyphenyl)amino]-2-(3,5-diethoxy-2-fluorophenyl)acetamide G17905 R-4-[2-(3-aminobenzenesulfonylamino)-1-(3,5-diethoxy-2-fluorophenyl)-2-oxoethylamino]-2-hydroxy-benzamidine.TFA
BDBM148173	Beta-secretase 1 Beta-secretase 2 Cathepsin D Cytochrome P450 1A Cytochrome P450 2C19 Cytochrome P450 2C8 Cytochrome P450 2D6 (2D6) Cytochrome P450 3A Potassium voltage-gated channel subfamily H member 2	0	11	0	0	0	0	0	0	US8962616, 1
BDBM148176	Beta-secretase 1 Beta-secretase 2 Cathepsin D Cytochrome P450 1A Cytochrome P450 2C19 Cytochrome P450 2C8 Cytochrome P450 2D6 (2D6) Cytochrome P450 3A Potassium voltage-gated channel subfamily H member 2	0	13	0	0	0	0	0	0	US8962616, 22 US8962616, 4
BDBM152692	Histone Deacetylase 10 (HDAC10) Histone deacetylase Histone deacetylase 1 Histone deacetylase 11 Histone deacetylase 2 Histone deacetylase 3 Histone deacetylase 6 Histone deacetylase 8 Histone deacetylase 8 (HDAC8)	0	11	0	0	0

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