Found 239 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Lysosomal acid glucosylceramidase
(Homo sapiens (Human)) | BDBM50182801
((3R,4R,5R)-5-(Hydroxymethyl)piperidine-3,4-diol, 8...)Show InChI InChI=1S/C6H13NO3/c8-3-4-1-7-2-5(9)6(4)10/h4-10H,1-3H2/t4-,5-,6-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
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| PDB US Patent
| 1.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Alectos Therapeutics Inc.
US Patent
| Assay Description Various concentrations of test compounds were prepared in DMSO and then diluted into buffer consisting of 50 mM sodium phosphate 0.25% w/v sodium tau... |
US Patent US9796680 (2017)
BindingDB Entry DOI: 10.7270/Q2SN0C36 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Lysosomal acid glucosylceramidase
(Homo sapiens (Human)) | BDBM50182801
((3R,4R,5R)-5-(Hydroxymethyl)piperidine-3,4-diol, 8...)Show InChI InChI=1S/C6H13NO3/c8-3-4-1-7-2-5(9)6(4)10/h4-10H,1-3H2/t4-,5-,6-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
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| PDB US Patent
| 1.70 | n/a | n/a | n/a | n/a | n/a | n/a | 7.0 | n/a |
Alectos Therapeutics Inc.
US Patent
| Assay Description Various concentrations of test compounds were prepared in DMSO and then diluted into buffer consisting of 50 mM sodium phosphate 0.25% w/v sodium tau... |
US Patent US10081601 (2018)
BindingDB Entry DOI: 10.7270/Q2S184JZ |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Beta-glucosidase
(Agrobacterium tumefaciens) | BDBM50182801
((3R,4R,5R)-5-(Hydroxymethyl)piperidine-3,4-diol, 8...)Show InChI InChI=1S/C6H13NO3/c8-3-4-1-7-2-5(9)6(4)10/h4-10H,1-3H2/t4-,5-,6-/m1/s1 | UniProtKB/SwissProt
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| Article PubMed
| 7 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Technische Universität Graz
Curated by ChEMBL
| Assay Description Inhibition of Agrobacterium sp. beta-glucosidase |
Bioorg Med Chem Lett 16: 2067-70 (2006)
Article DOI: 10.1016/j.bmcl.2006.01.095 BindingDB Entry DOI: 10.7270/Q26Q1WV2 |
More data for this Ligand-Target Pair | |
Neutral alpha-glucosidase AB
(Homo sapiens (Human)) | BDBM18351
((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)Show InChI InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
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| 14 | n/a | n/a | n/a | n/a | n/a | n/a | 6.0 | n/a |
TBA
Curated by ChEMBL
| Assay Description Competitive Inhibition constant of the compound was determined on rice alpha Glucosidase at pH 8.0 |
Bioorg Med Chem Lett 2: 27-32 (1992)
Article DOI: 10.1016/S0960-894X(00)80648-4 BindingDB Entry DOI: 10.7270/Q2TH8MKB |
More data for this Ligand-Target Pair | |
Sucrase-isomaltase, intestinal
(Rattus norvegicus (Rat)) | BDBM18351
((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)Show InChI InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1 | UniProtKB/SwissProt
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| Article
| 24 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Tested in vitro for the inhibition constant against rat small intestinal sucrase |
Bioorg Med Chem Lett 7: 355-360 (1997)
Article DOI: 10.1016/S0960-894X(97)00012-7 BindingDB Entry DOI: 10.7270/Q2F18ZQ1 |
More data for this Ligand-Target Pair | |
Lysosomal alpha-glucosidase
(Homo sapiens (Human)) | BDBM18351
((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)Show InChI InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1 | PDB
NCI pathway KEGG
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| Article PubMed
| 59 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human GAA using 4-methylumbelliferyl-alpha-D-glucopyranoside as substrate preincubated for 45 min followed by substrate addition and me... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01673 BindingDB Entry DOI: 10.7270/Q23J3HVM |
More data for this Ligand-Target Pair | |
Lysosomal alpha-glucosidase
(Homo sapiens (Human)) | BDBM18351
((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)Show InChI InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1 | PDB
NCI pathway KEGG
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| 150 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Tested in vitro for the inhibition constant against human lysosomal alpha-glucosidase |
Bioorg Med Chem Lett 7: 355-360 (1997)
Article DOI: 10.1016/S0960-894X(97)00012-7 BindingDB Entry DOI: 10.7270/Q2F18ZQ1 |
More data for this Ligand-Target Pair | |
Neutral alpha-glucosidase AB
(Homo sapiens (Human)) | BDBM18351
((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)Show InChI InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1 | PDB
Reactome pathway KEGG
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| Article
| 160 | n/a | n/a | n/a | n/a | n/a | n/a | 5.0 | n/a |
TBA
Curated by ChEMBL
| Assay Description Competitive Inhibition constant of the compound was determined on yeast alpha Glucosidase at pH 5.0 |
Bioorg Med Chem Lett 2: 27-32 (1992)
Article DOI: 10.1016/S0960-894X(00)80648-4 BindingDB Entry DOI: 10.7270/Q2TH8MKB |
More data for this Ligand-Target Pair | |
Trehalose synthase/amylase TreS
(Mycobacterium tuberculosis) | BDBM18351
((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)Show InChI InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1 | PDB
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| Article PubMed
| 250 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of British Columbia
| Assay Description The inhibition of TreS by a range of known alpha-glucosidase inhibitor was assayed. |
J Biol Chem 286: 35601-9 (2011)
Article DOI: 10.1074/jbc.M111.280362 BindingDB Entry DOI: 10.7270/Q2VM49V1 |
More data for this Ligand-Target Pair | |
Lysosomal acid glucosylceramidase
(Homo sapiens (Human)) | BDBM50182798
((3R,4r,5S)-piperidine-3,4,5-triol | 1,5-Dideoxy-1,...)Show InChI InChI=1S/C5H11NO3/c7-3-1-6-2-4(8)5(3)9/h3-9H,1-2H2/t3-,4+,5+ | PDB MMDB
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| Article PubMed
| 1.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Technical University Graz
Curated by ChEMBL
| Assay Description Inhibition of human lysosomal beta-glucocerebrosidase |
Bioorg Med Chem Lett 24: 2777-80 (2014)
Article DOI: 10.1016/j.bmcl.2014.03.069 BindingDB Entry DOI: 10.7270/Q2RV0Q8B |
More data for this Ligand-Target Pair | |
Lysosomal acid glucosylceramidase
(Homo sapiens (Human)) | BDBM50182798
((3R,4r,5S)-piperidine-3,4,5-triol | 1,5-Dideoxy-1,...)Show InChI InChI=1S/C5H11NO3/c7-3-1-6-2-4(8)5(3)9/h3-9H,1-2H2/t3-,4+,5+ | PDB MMDB
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| Article PubMed
| 2.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a | 5.0 | n/a |
University of British Columbia
Curated by ChEMBL
| Assay Description Competitive inhibition of wild type human glucocerebrosidase using 2,4-dinitrophenyl beta-D-glucopyranoside as substrate after 3 mins by Dixon and Li... |
J Med Chem 55: 2737-45 (2012)
Article DOI: 10.1021/jm201633y BindingDB Entry DOI: 10.7270/Q2639QSX |
More data for this Ligand-Target Pair | |
Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase
(Homo sapiens (Human)) | BDBM50402978
(CHEMBL2207396)Show InChI InChI=1S/C4H9NO2/c6-3-1-5-2-4(3)7/h3-7H,1-2H2/t3-,4+ | PDB MMDB
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| Article PubMed
| 3.24E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universidade do Porto 687
Curated by ChEMBL
| Assay Description Inhibition of human ER alpha mannosidase 1 |
Bioorg Med Chem 20: 6945-59 (2012)
Article DOI: 10.1016/j.bmc.2012.10.011 BindingDB Entry DOI: 10.7270/Q26T0NTC |
More data for this Ligand-Target Pair | |
Lysosomal alpha-glucosidase
(Homo sapiens (Human)) | BDBM18351
((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)Show InChI InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1 | PDB
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| | 3.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Glycogen phosphorylase, muscle form
(Oryctolagus cuniculus (rabbit)) | BDBM50182801
((3R,4R,5R)-5-(Hydroxymethyl)piperidine-3,4-diol, 8...)Show InChI InChI=1S/C6H13NO3/c8-3-4-1-7-2-5(9)6(4)10/h4-10H,1-3H2/t4-,5-,6-/m1/s1 | PDB MMDB
KEGG
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| PDB Article PubMed
| 5.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The National Hellenic Research Foundation
Curated by ChEMBL
| Assay Description Inhibition of non-phosphorylated form of rabbit muscle glycogen phosphorylase in presence of phosphate |
J Med Chem 49: 5687-701 (2006)
Article DOI: 10.1021/jm060496g BindingDB Entry DOI: 10.7270/Q25Q4VQP |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Beta-glucosidase
(Prunus avium) | BDBM18351
((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)Show InChI InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1 | UniProtKB/TrEMBL
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| Article
| 9.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibitory activity against sweet almond Beta-glucosidase |
Bioorg Med Chem Lett 1: 667-672 (1991)
Article DOI: 10.1016/S0960-894X(01)81044-1 BindingDB Entry DOI: 10.7270/Q26W9BKM |
More data for this Ligand-Target Pair | |
Beta-glucosidase
(Agrobacterium tumefaciens) | BDBM18351
((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)Show InChI InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1 | UniProtKB/SwissProt
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| Article PubMed
| 1.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Technical University Graz
Curated by ChEMBL
| Assay Description Inhibition of Agrobacterium sp. beta glucosidase |
Bioorg Med Chem Lett 24: 2777-80 (2014)
Article DOI: 10.1016/j.bmcl.2014.03.069 BindingDB Entry DOI: 10.7270/Q2RV0Q8B |
More data for this Ligand-Target Pair | |
Beta-glucosidase
(Agrobacterium tumefaciens) | BDBM18351
((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)Show InChI InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1 | UniProtKB/SwissProt
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| Article PubMed
| 1.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Technische Universität Graz
Curated by ChEMBL
| Assay Description Inhibition of Agrobacterium sp. beta-glucosidase |
Bioorg Med Chem Lett 16: 2067-70 (2006)
Article DOI: 10.1016/j.bmcl.2006.01.095 BindingDB Entry DOI: 10.7270/Q26Q1WV2 |
More data for this Ligand-Target Pair | |
Alpha-glucosidase MAL12
(Saccharomyces cerevisiae) | BDBM18351
((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)Show InChI InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1 | Reactome pathway KEGG
UniProtKB/SwissProt
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| Article PubMed
| 1.80E+4 | n/a | 3.95E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Gyeongsang National University
| Assay Description All enzymatic activities were determined by using the appropriate substrate (p-nitrophenyl-alpha-D-glucopyranoside, p-nitrophenyl-beta-D-gulcopyranos... |
Chembiochem 11: 2125-31 (2010)
Article DOI: 10.1002/cbic.201000376 BindingDB Entry DOI: 10.7270/Q2542M33 |
More data for this Ligand-Target Pair | |
Alpha-galactosidase A
(Homo sapiens (Human)) | BDBM18351
((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)Show InChI InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1 | PDB MMDB
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| MMDB PDB PubMed
| 1.80E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Hamburg
Curated by ChEMBL
| Assay Description Compound tested for inhibition of alpha-galactosidase from Aspergillus niger |
Bioorg Med Chem Lett 14: 73-5 (2003)
BindingDB Entry DOI: 10.7270/Q2JM2925 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Beta-glucosidase A
(Caldocellum saccharolyticum) | BDBM50403869
(CHEMBL2115197)Show InChI InChI=1S/C6H13NO2/c1-2-4-6(9)5(8)3-7-4/h4-9H,2-3H2,1H3/t4-,5+,6-/m1/s1 | KEGG
UniProtKB/SwissProt
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| PubMed
| 1.90E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Section de Chimie de l'Universit£ de Lausanne
Curated by ChEMBL
| Assay Description Inhibitory activity towards Beta-Glucosidase from Caldocellum saccharol. |
Bioorg Med Chem Lett 11: 2489-93 (2001)
BindingDB Entry DOI: 10.7270/Q2H70GBZ |
More data for this Ligand-Target Pair | |
Beta-glucosidase A
(Caldocellum saccharolyticum) | BDBM50402977
(CHEMBL2207397)Show InChI InChI=1S/C6H13NO4/c8-2-4(10)5-6(11)3(9)1-7-5/h3-11H,1-2H2/t3-,4?,5+,6-/m0/s1 | KEGG
UniProtKB/SwissProt
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| PubMed
| 1.90E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Section de Chimie de l'Universit£ de Lausanne
Curated by ChEMBL
| Assay Description Inhibitory activity towards Beta-Glucosidase from Caldocellum saccharol |
Bioorg Med Chem Lett 11: 2489-93 (2001)
BindingDB Entry DOI: 10.7270/Q2H70GBZ |
More data for this Ligand-Target Pair | |
Neutral alpha-glucosidase AB
(Homo sapiens (Human)) | BDBM18351
((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)Show InChI InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1 | PDB
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| Article
| 2.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a | 7.0 | n/a |
TBA
Curated by ChEMBL
| Assay Description Competitive Inhibition constant of the compound was determined on yeast alpha Glucosidase at pH 7.0 |
Bioorg Med Chem Lett 2: 27-32 (1992)
Article DOI: 10.1016/S0960-894X(00)80648-4 BindingDB Entry DOI: 10.7270/Q2TH8MKB |
More data for this Ligand-Target Pair | |
Neutral alpha-glucosidase AB
(Homo sapiens (Human)) | BDBM18351
((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)Show InChI InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1 | PDB
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| Article
| 2.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a | 6.0 | n/a |
TBA
Curated by ChEMBL
| Assay Description Competitive Inhibition constant of the compound was determined on yeast alpha Glucosidase at pH 6.0 |
Bioorg Med Chem Lett 2: 27-32 (1992)
Article DOI: 10.1016/S0960-894X(00)80648-4 BindingDB Entry DOI: 10.7270/Q2TH8MKB |
More data for this Ligand-Target Pair | |
Lysosomal alpha-glucosidase
(Homo sapiens (Human)) | BDBM18351
((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)Show InChI InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1 | PDB
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| 2.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Technische Universit£t Berlin
Curated by ChEMBL
| Assay Description Inhibitory activity against alpha-glucosidase of yeast |
Bioorg Med Chem Lett 9: 615-8 (1999)
BindingDB Entry DOI: 10.7270/Q2V40VQH |
More data for this Ligand-Target Pair | |
Beta-galactosidase
(Homo sapiens (Human)) | BDBM50104296
(2-(2,2-Dihydroxy-ethyl)-pyrrolidine-3,4-diol | CHE...)Show InChI InChI=1S/C6H13NO4/c8-4-2-7-3(6(4)11)1-5(9)10/h3-11H,1-2H2 | PDB
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| PubMed
| 2.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Section de Chimie de l'Universit£ de Lausanne
Curated by ChEMBL
| Assay Description Inhibitory activity towards Beta-galactosidase from Jack bean |
Bioorg Med Chem Lett 11: 2489-93 (2001)
BindingDB Entry DOI: 10.7270/Q2H70GBZ |
More data for this Ligand-Target Pair | |
Beta-glucosidase A
(Caldocellum saccharolyticum) | BDBM50104296
(2-(2,2-Dihydroxy-ethyl)-pyrrolidine-3,4-diol | CHE...)Show InChI InChI=1S/C6H13NO4/c8-4-2-7-3(6(4)11)1-5(9)10/h3-11H,1-2H2 | KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
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| PubMed
| 2.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Section de Chimie de l'Universit£ de Lausanne
Curated by ChEMBL
| Assay Description Inhibitory activity towards Beta-Glucosidase from Caldocellum saccharol |
Bioorg Med Chem Lett 11: 2489-93 (2001)
BindingDB Entry DOI: 10.7270/Q2H70GBZ |
More data for this Ligand-Target Pair | |
Beta-glucosidase
(Prunus avium) | BDBM50104296
(2-(2,2-Dihydroxy-ethyl)-pyrrolidine-3,4-diol | CHE...)Show InChI InChI=1S/C6H13NO4/c8-4-2-7-3(6(4)11)1-5(9)10/h3-11H,1-2H2 | UniProtKB/TrEMBL
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
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| PubMed
| 2.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Section de Chimie de l'Universit£ de Lausanne
Curated by ChEMBL
| Assay Description Inhibitory activity towards Beta-Glucosidase from Almond |
Bioorg Med Chem Lett 11: 2489-93 (2001)
BindingDB Entry DOI: 10.7270/Q2H70GBZ |
More data for this Ligand-Target Pair | |
Lysosomal acid glucosylceramidase
(Homo sapiens (Human)) | BDBM50018016
(CHEMBL3289677)Show InChI InChI=1S/C6H10N2O3/c7-1-3-5(10)6(11)4(9)2-8-3/h3-6,8-11H,2H2/t3-,4-,5+,6+/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
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| Article PubMed
| 3.40E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Technical University Graz
Curated by ChEMBL
| Assay Description Inhibition of human lysosomal beta-glucocerebrosidase using 2,4-dinitrophenyl-beta-D-glucopyranoside as substrate by UV spectrophotometric analysis |
Bioorg Med Chem Lett 24: 2777-80 (2014)
Article DOI: 10.1016/j.bmcl.2014.03.069 BindingDB Entry DOI: 10.7270/Q2RV0Q8B |
More data for this Ligand-Target Pair | |
alpha-1,2-Mannosidase
(Glycine max) | BDBM50402978
(CHEMBL2207396)Show InChI InChI=1S/C4H9NO2/c6-3-1-5-2-4(3)7/h3-7H,1-2H2/t3-,4+ | KEGG
UniProtKB/TrEMBL
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| 4.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Section de Chimie de l'Universit£ de Lausanne
Curated by ChEMBL
| Assay Description Inhibitory activity towards Alpha-mannosidase from Almond |
Bioorg Med Chem Lett 11: 2489-93 (2001)
BindingDB Entry DOI: 10.7270/Q2H70GBZ |
More data for this Ligand-Target Pair | |
Glucoamylase 1
(Rhizopus oryzae) | BDBM50403869
(CHEMBL2115197)Show InChI InChI=1S/C6H13NO2/c1-2-4-6(9)5(8)3-7-4/h4-9H,2-3H2,1H3/t4-,5+,6-/m1/s1 | PDB MMDB
UniProtKB/SwissProt
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| PubMed
| 4.40E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Section de Chimie de l'Universit£ de Lausanne
Curated by ChEMBL
| Assay Description Inhibitory activity towards Alpha-glucosidase from Rhizopus mold (amyloglucosidase) |
Bioorg Med Chem Lett 11: 2489-93 (2001)
BindingDB Entry DOI: 10.7270/Q2H70GBZ |
More data for this Ligand-Target Pair | |
Lysosomal acid glucosylceramidase
(Homo sapiens (Human)) | BDBM18351
((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)Show InChI InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1 | PDB MMDB
Reactome pathway KEGG
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| 4.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Technische Universit£t Berlin
Curated by ChEMBL
| Assay Description Inhibitory activity against beta-glucosidase of sweet almond |
Bioorg Med Chem Lett 9: 615-8 (1999)
BindingDB Entry DOI: 10.7270/Q2V40VQH |
More data for this Ligand-Target Pair | |
Beta-glucosidase
(Agrobacterium tumefaciens) | BDBM50182798
((3R,4r,5S)-piperidine-3,4,5-triol | 1,5-Dideoxy-1,...)Show InChI InChI=1S/C5H11NO3/c7-3-1-6-2-4(8)5(3)9/h3-9H,1-2H2/t3-,4+,5+ | UniProtKB/SwissProt
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| 5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Technical University Graz
Curated by ChEMBL
| Assay Description Inhibition of Agrobacterium sp. beta glucosidase |
Bioorg Med Chem Lett 24: 2777-80 (2014)
Article DOI: 10.1016/j.bmcl.2014.03.069 BindingDB Entry DOI: 10.7270/Q2RV0Q8B |
More data for this Ligand-Target Pair | |
Alpha-mannosidase 2
(Rattus norvegicus) | BDBM18351
((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)Show InChI InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1 | Reactome pathway KEGG
UniProtKB/SwissProt
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| <5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Hokuriku University
Curated by ChEMBL
| Assay Description Competitive Inhibitory activity against Golgi Alpha-mannosidase II |
J Med Chem 38: 2349-56 (1995)
BindingDB Entry DOI: 10.7270/Q2N878T0 |
More data for this Ligand-Target Pair | |
Beta-glucosidase
(Prunus avium) | BDBM50402977
(CHEMBL2207397)Show InChI InChI=1S/C6H13NO4/c8-2-4(10)5-6(11)3(9)1-7-5/h3-11H,1-2H2/t3-,4?,5+,6-/m0/s1 | UniProtKB/TrEMBL
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| CHEMBL PC cid PC sid UniChem
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| 5.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Section de Chimie de l'Universit£ de Lausanne
Curated by ChEMBL
| Assay Description Inhibitory activity towards Beta-Glucosidase from Almond |
Bioorg Med Chem Lett 11: 2489-93 (2001)
BindingDB Entry DOI: 10.7270/Q2H70GBZ |
More data for this Ligand-Target Pair | |
Beta-glucosidase
(Prunus avium) | BDBM50403869
(CHEMBL2115197)Show InChI InChI=1S/C6H13NO2/c1-2-4-6(9)5(8)3-7-4/h4-9H,2-3H2,1H3/t4-,5+,6-/m1/s1 | UniProtKB/TrEMBL
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
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| 5.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Section de Chimie de l'Universit£ de Lausanne
Curated by ChEMBL
| Assay Description Inhibitory activity towards Beta-Glucosidase from Almond |
Bioorg Med Chem Lett 11: 2489-93 (2001)
BindingDB Entry DOI: 10.7270/Q2H70GBZ |
More data for this Ligand-Target Pair | |
Glucoamylase
(Aspergillus niger) | BDBM50403869
(CHEMBL2115197)Show InChI InChI=1S/C6H13NO2/c1-2-4-6(9)5(8)3-7-4/h4-9H,2-3H2,1H3/t4-,5+,6-/m1/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
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| CHEMBL PC cid PC sid UniChem
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| 6.40E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Section de Chimie de l'Universit£ de Lausanne
Curated by ChEMBL
| Assay Description Inhibitory activity towards Alpha-glucosidase from Aspergillus niger (amyloglucosidase) |
Bioorg Med Chem Lett 11: 2489-93 (2001)
BindingDB Entry DOI: 10.7270/Q2H70GBZ |
More data for this Ligand-Target Pair | |
Lysosomal acid glucosylceramidase
(Homo sapiens (Human)) | BDBM18351
((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)Show InChI InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1 | PDB MMDB
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| 7.90E+4 | -24.4 | 2.40E+5 | n/a | n/a | n/a | n/a | 5.5 | 37 |
Hokuriku University
| Assay Description Enzyme activity was determined as the production of fluorescent 4-MU from the substrate. The fluorescence was measured (excitation 362 nm, emission 4... |
Bioorg Med Chem 14: 7736-44 (2006)
Article DOI: 10.1016/j.bmc.2006.08.003 BindingDB Entry DOI: 10.7270/Q2BZ649B |
More data for this Ligand-Target Pair | |
Lysosomal acid glucosylceramidase
(Homo sapiens (Human)) | BDBM18351
((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)Show InChI InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1 | PDB MMDB
Reactome pathway KEGG
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| Article PubMed
| 7.90E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Technical University Graz
Curated by ChEMBL
| Assay Description Inhibition of human lysosomal beta-glucocerebrosidase |
Bioorg Med Chem Lett 24: 2777-80 (2014)
Article DOI: 10.1016/j.bmcl.2014.03.069 BindingDB Entry DOI: 10.7270/Q2RV0Q8B |
More data for this Ligand-Target Pair | |
alpha-1,2-Mannosidase
(Glycine max) | BDBM50104296
(2-(2,2-Dihydroxy-ethyl)-pyrrolidine-3,4-diol | CHE...)Show InChI InChI=1S/C6H13NO4/c8-4-2-7-3(6(4)11)1-5(9)10/h3-11H,1-2H2 | KEGG
UniProtKB/TrEMBL
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| 8.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Section de Chimie de l'Universit£ de Lausanne
Curated by ChEMBL
| Assay Description Inhibitory activity towards Alpha-mannosidase from Jack bean |
Bioorg Med Chem Lett 11: 2489-93 (2001)
BindingDB Entry DOI: 10.7270/Q2H70GBZ |
More data for this Ligand-Target Pair | |
Trehalose synthase/amylase TreS
(Mycobacterium tuberculosis) | BDBM50182801
((3R,4R,5R)-5-(Hydroxymethyl)piperidine-3,4-diol, 8...)Show InChI InChI=1S/C6H13NO3/c8-3-4-1-7-2-5(9)6(4)10/h4-10H,1-3H2/t4-,5-,6-/m1/s1 | PDB
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| 1.40E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of British Columbia
| Assay Description The inhibition of TreS by a range of known alpha-glucosidase inhibitor was assayed. |
J Biol Chem 286: 35601-9 (2011)
Article DOI: 10.1074/jbc.M111.280362 BindingDB Entry DOI: 10.7270/Q2VM49V1 |
More data for this Ligand-Target Pair | |
Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase
(Homo sapiens (Human)) | BDBM50402977
(CHEMBL2207397)Show InChI InChI=1S/C6H13NO4/c8-2-4(10)5-6(11)3(9)1-7-5/h3-11H,1-2H2/t3-,4?,5+,6-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
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| CHEMBL PC cid PC sid UniChem
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| Article PubMed
| 1.69E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universidade do Porto 687
Curated by ChEMBL
| Assay Description Inhibition of human ER alpha mannosidase 1 |
Bioorg Med Chem 20: 6945-59 (2012)
Article DOI: 10.1016/j.bmc.2012.10.011 BindingDB Entry DOI: 10.7270/Q26T0NTC |
More data for this Ligand-Target Pair | |
Beta-galactosidase
(Aspergillus niger) | BDBM50104296
(2-(2,2-Dihydroxy-ethyl)-pyrrolidine-3,4-diol | CHE...)Show InChI InChI=1S/C6H13NO4/c8-4-2-7-3(6(4)11)1-5(9)10/h3-11H,1-2H2 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
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| PubMed
| 2.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Section de Chimie de l'Universit£ de Lausanne
Curated by ChEMBL
| Assay Description Inhibitory activity towards Beta-galactosidase from Aspergillus niger |
Bioorg Med Chem Lett 11: 2489-93 (2001)
BindingDB Entry DOI: 10.7270/Q2H70GBZ |
More data for this Ligand-Target Pair | |
Beta-xylosidase
(Thermoanaerobacter saccharolyticum) | BDBM50182798
((3R,4r,5S)-piperidine-3,4,5-triol | 1,5-Dideoxy-1,...)Show InChI InChI=1S/C5H11NO3/c7-3-1-6-2-4(8)5(3)9/h3-9H,1-2H2/t3-,4+,5+ | PDB MMDB
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| 2.06E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Technische Universität Graz
Curated by ChEMBL
| Assay Description Inhibition of Thermoanaerobacterium saccharolyticum beta-xylosidase |
Bioorg Med Chem Lett 16: 2067-70 (2006)
Article DOI: 10.1016/j.bmcl.2006.01.095 BindingDB Entry DOI: 10.7270/Q26Q1WV2 |
More data for this Ligand-Target Pair | |
Beta-glucosidase
(Agrobacterium tumefaciens) | BDBM50018016
(CHEMBL3289677)Show InChI InChI=1S/C6H10N2O3/c7-1-3-5(10)6(11)4(9)2-8-3/h3-6,8-11H,2H2/t3-,4-,5+,6+/m1/s1 | UniProtKB/SwissProt
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| Article PubMed
| 2.20E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Technical University Graz
Curated by ChEMBL
| Assay Description Inhibition of Agrobacterium sp. beta glucosidase using 2,4-dinitrophenyl-beta-D-glucopyranoside as substrate measured for 3 mins |
Bioorg Med Chem Lett 24: 2777-80 (2014)
Article DOI: 10.1016/j.bmcl.2014.03.069 BindingDB Entry DOI: 10.7270/Q2RV0Q8B |
More data for this Ligand-Target Pair | |
Alpha-mannosidase 2
(Homo sapiens (Human)) | BDBM50402977
(CHEMBL2207397)Show InChI InChI=1S/C6H13NO4/c8-2-4(10)5-6(11)3(9)1-7-5/h3-11H,1-2H2/t3-,4?,5+,6-/m0/s1 | Reactome pathway KEGG
UniProtKB/SwissProt
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| Article PubMed
| 2.29E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universidade do Porto 687
Curated by ChEMBL
| Assay Description Inhibition of human golgi alpha mannosidase 2 |
Bioorg Med Chem 20: 6945-59 (2012)
Article DOI: 10.1016/j.bmc.2012.10.011 BindingDB Entry DOI: 10.7270/Q26T0NTC |
More data for this Ligand-Target Pair | |
Alpha-mannosidase
(Canavalia ensiformis) | BDBM18351
((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)Show InChI InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1 | PDB
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| Article PubMed
| 2.70E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Copenhagen
Curated by ChEMBL
| Assay Description Inhibition of jack bean alpha-mannosidase using p-nitrophenyl-mannopyranoside as substrate measured every 2 mins |
Eur J Med Chem 123: 155-160 (2016)
Article DOI: 10.1016/j.ejmech.2016.07.021 BindingDB Entry DOI: 10.7270/Q2C24ZD6 |
More data for this Ligand-Target Pair | |
Lysosomal acid glucosylceramidase
(Homo sapiens (Human)) | BDBM18351
((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)Show InChI InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1 | PDB MMDB
Reactome pathway KEGG
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| Article
| 3.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a | 5.0 | n/a |
TBA
Curated by ChEMBL
| Assay Description Competitive Inhibition constant of the compound was determined on yeast alpha Glucosidase at pH 7.0 |
Bioorg Med Chem Lett 2: 27-32 (1992)
Article DOI: 10.1016/S0960-894X(00)80648-4 BindingDB Entry DOI: 10.7270/Q2TH8MKB |
More data for this Ligand-Target Pair | |
Lysosomal acid glucosylceramidase
(Homo sapiens (Human)) | BDBM18351
((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)Show InChI InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1 | PDB MMDB
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| Article
| 3.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a | 5.0 | n/a |
TBA
Curated by ChEMBL
| Assay Description Competitive Inhibition constant of the compound was determined on almonds beta Glucosidase at pH 5.0 |
Bioorg Med Chem Lett 2: 27-32 (1992)
Article DOI: 10.1016/S0960-894X(00)80648-4 BindingDB Entry DOI: 10.7270/Q2TH8MKB |
More data for this Ligand-Target Pair | |
Neutral alpha-glucosidase AB
(Homo sapiens (Human)) | BDBM18351
((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)Show InChI InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1 | PDB
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| PubMed
| 4.10E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Hokuriku University
Curated by ChEMBL
| Assay Description Tested for competitive inhibition of golgi alpha mannosidase II |
J Med Chem 37: 3701-6 (1994)
BindingDB Entry DOI: 10.7270/Q2ZC83H3 |
More data for this Ligand-Target Pair | |
Neutral alpha-glucosidase AB
(Homo sapiens (Human)) | BDBM18351
((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)Show InChI InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1 | PDB
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| Article
| 4.60E+5 | n/a | n/a | n/a | n/a | n/a | n/a | 5.0 | n/a |
TBA
Curated by ChEMBL
| Assay Description Competitive Inhibition constant of the compound was determined on rice alpha Glucosidase at pH 5.0 |
Bioorg Med Chem Lett 2: 27-32 (1992)
Article DOI: 10.1016/S0960-894X(00)80648-4 BindingDB Entry DOI: 10.7270/Q2TH8MKB |
More data for this Ligand-Target Pair | |