Compile Data Set for Download or QSAR

Found 1196 hits with Last Name = 'kormos' and Initial = 'bl'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cGMP-dependent 3',5'-cyclic phosphodiesterase (Rattus norvegicus)	BDBM107767 (US11419874, PF-05180999 | US8598155, 2) Show SMILES Cc1nc(-c2cnn(C)c2-c2ccc(cn2)C(F)(F)F)c2c(ncnn12)N1CCC1 Show InChI InChI=1S/C19H17F3N8/c1-11-27-15(17-18(29-6-3-7-29)24-10-26-30(11)17)13-9-25-28(2)16(13)14-5-4-12(8-23-14)19(20,21)22/h4-5,8-10H,3,6-7H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	4.20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Displacement of radiolabeled 4-(azetidin-1-yl)-3-[5-[4-(trifluoromethyl)phenyl]-1H-pyrazol-4-yl]-1-(tritritiomethyl)pyrazolo[3,4-d]pyrimidine from PD...				J Med Chem 61: 1001-1018 (2018) Article DOI: 10.1021/acs.jmedchem.7b01466 BindingDB Entry DOI: 10.7270/Q2ZS2ZZ4
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM142586 (US8933224, 4) Show SMILES COc1ccc2CCN(Cc2c1OCCF)c1ncnn2c(C)nc([C@@H]3CCOC3)c12 Show InChI InChI=1S/C22H26FN5O3/c1-14-26-19(16-6-9-30-12-16)20-22(24-13-25-28(14)20)27-8-5-15-3-4-18(29-2)21(17(15)11-27)31-10-7-23/h3-4,13,16H,5-12H2,1-2H3/t16-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.0386	n/a	n/a	n/a	n/a	7.5	n/a
Pfizer Inc. US Patent					Assay Description The ability of a compound to inhibit PDE10 enzymatic activity can be demonstrated by any number of assays that are known in the art. The products of ...				US Patent US8933224 (2015) BindingDB Entry DOI: 10.7270/Q2WM1C35
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM142493 (US8933224, 86) Show SMILES CC(C)c1nn(C)c2CCN(Cc12)c1ncnn2c(C)nc([C@@H]3CCOC3)c12 |r| Show InChI InChI=1S/C20H27N7O/c1-12(2)17-15-9-26(7-5-16(15)25(4)24-17)20-19-18(14-6-8-28-10-14)23-13(3)27(19)22-11-21-20/h11-12,14H,5-10H2,1-4H3/t14-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.0444	n/a	n/a	n/a	n/a	7.5	n/a
Pfizer Inc. US Patent					Assay Description The ability of a compound to inhibit PDE10 enzymatic activity can be demonstrated by any number of assays that are known in the art. The products of ...				US Patent US8933224 (2015) BindingDB Entry DOI: 10.7270/Q2WM1C35
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Rattus norvegicus (rat))	BDBM142557 (US8933224, 150) Show SMILES CCn1c(nc2CCN(Cc2c1=O)c1ncnn2c(C)nc([C@@H]3CCOC3)c12)C1CC1 |r| Show InChI InChI=1S/C22H27N7O2/c1-3-28-20(14-4-5-14)26-17-6-8-27(10-16(17)22(28)30)21-19-18(15-7-9-31-11-15)25-13(2)29(19)24-12-23-21/h12,14-15H,3-11H2,1-2H3/t15-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.0697	n/a	n/a	n/a	n/a	7.5	n/a
Pfizer Inc. US Patent					Assay Description The ability of a compound to inhibit PDE10 enzymatic activity can be demonstrated by any number of assays that are known in the art. The products of ...				US Patent US8933224 (2015) BindingDB Entry DOI: 10.7270/Q2WM1C35
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM142544 (US8933224, 137) Show SMILES CCc1nc(nc2CCN(Cc12)c1ncnn2c(C)nc([C@@H]3CCOC3)c12)C1CC1 |r| Show InChI InChI=1S/C22H27N7O/c1-3-17-16-10-28(8-6-18(16)27-21(26-17)14-4-5-14)22-20-19(15-7-9-30-11-15)25-13(2)29(20)24-12-23-22/h12,14-15H,3-11H2,1-2H3/t15-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.0777	n/a	n/a	n/a	n/a	7.5	n/a
Pfizer Inc. US Patent					Assay Description The ability of a compound to inhibit PDE10 enzymatic activity can be demonstrated by any number of assays that are known in the art. The products of ...				US Patent US8933224 (2015) BindingDB Entry DOI: 10.7270/Q2WM1C35
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Rattus norvegicus (rat))	BDBM142550 (US8933224, 143 | US8933224, 144) Show SMILES Cc1nc([C@@H]2CCOC2)c2c(ncnn12)N1CCc2nc(C3CC3)n(C)c(=O)c2C1 |r| Show InChI InChI=1S/C21H25N7O2/c1-12-24-17(14-6-8-30-10-14)18-20(22-11-23-28(12)18)27-7-5-16-15(9-27)21(29)26(2)19(25-16)13-3-4-13/h11,13-14H,3-10H2,1-2H3/t14-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.0837	n/a	n/a	n/a	n/a	7.5	n/a
Pfizer Inc. US Patent					Assay Description The ability of a compound to inhibit PDE10 enzymatic activity can be demonstrated by any number of assays that are known in the art. The products of ...				US Patent US8933224 (2015) BindingDB Entry DOI: 10.7270/Q2WM1C35
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Rattus norvegicus (rat))	BDBM142481 (US8933224, 74) Show SMILES Cc1nc([C@@H]2CCOC2)c2c(ncnn12)N1CCc2ccc(nc2C1)C1CC1 |r| Show InChI InChI=1S/C21H24N6O/c1-13-24-19(16-7-9-28-11-16)20-21(22-12-23-27(13)20)26-8-6-15-4-5-17(14-2-3-14)25-18(15)10-26/h4-5,12,14,16H,2-3,6-11H2,1H3/t16-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.0896	n/a	n/a	n/a	n/a	7.5	n/a
Pfizer Inc. US Patent					Assay Description The ability of a compound to inhibit PDE10 enzymatic activity can be demonstrated by any number of assays that are known in the art. The products of ...				US Patent US8933224 (2015) BindingDB Entry DOI: 10.7270/Q2WM1C35
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Rattus norvegicus (rat))	BDBM142544 (US8933224, 137) Show SMILES CCc1nc(nc2CCN(Cc12)c1ncnn2c(C)nc([C@@H]3CCOC3)c12)C1CC1 |r| Show InChI InChI=1S/C22H27N7O/c1-3-17-16-10-28(8-6-18(16)27-21(26-17)14-4-5-14)22-20-19(15-7-9-30-11-15)25-13(2)29(20)24-12-23-22/h12,14-15H,3-11H2,1-2H3/t15-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.0950	n/a	n/a	n/a	n/a	7.5	n/a
Pfizer Inc. US Patent					Assay Description The ability of a compound to inhibit PDE10 enzymatic activity can be demonstrated by any number of assays that are known in the art. The products of ...				US Patent US8933224 (2015) BindingDB Entry DOI: 10.7270/Q2WM1C35
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Rattus norvegicus (rat))	BDBM142536 (US8933224, 129) Show SMILES CCn1c(C)nc2CCN(Cc2c1=O)c1ncnn2c(C)nc([C@@H]3CCOC3)c12 |r| Show InChI InChI=1S/C20H25N7O2/c1-4-26-12(2)23-16-5-7-25(9-15(16)20(26)28)19-18-17(14-6-8-29-10-14)24-13(3)27(18)22-11-21-19/h11,14H,4-10H2,1-3H3/t14-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.0998	n/a	n/a	n/a	n/a	7.5	n/a
Pfizer Inc. US Patent					Assay Description The ability of a compound to inhibit PDE10 enzymatic activity can be demonstrated by any number of assays that are known in the art. The products of ...				US Patent US8933224 (2015) BindingDB Entry DOI: 10.7270/Q2WM1C35
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Rattus norvegicus (rat))	BDBM142459 (US8933224, 52) Show SMILES Cc1nc([C@@H]2CCOC2)c2c(ncnn12)N1CCc2nc(nc(O)c2C1)C1CC1 |r| Show InChI InChI=1S/C20H23N7O2/c1-11-23-16(13-5-7-29-9-13)17-19(21-10-22-27(11)17)26-6-4-15-14(8-26)20(28)25-18(24-15)12-2-3-12/h10,12-13H,2-9H2,1H3,(H,24,25,28)/t13-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.101	n/a	n/a	n/a	n/a	7.5	n/a
Pfizer Inc. US Patent					Assay Description The ability of a compound to inhibit PDE10 enzymatic activity can be demonstrated by any number of assays that are known in the art. The products of ...				US Patent US8933224 (2015) BindingDB Entry DOI: 10.7270/Q2WM1C35
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Rattus norvegicus (rat))	BDBM142451 (US8933224, 44) Show SMILES Cc1nc([C@@H]2CCOC2)c2c(ncnn12)N1CCc2nn(C)c(C3CC3)c2C1 |r| Show InChI InChI=1S/C20H25N7O/c1-12-23-17(14-6-8-28-10-14)19-20(21-11-22-27(12)19)26-7-5-16-15(9-26)18(13-3-4-13)25(2)24-16/h11,13-14H,3-10H2,1-2H3/t14-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.102	n/a	n/a	n/a	n/a	7.5	n/a
Pfizer Inc. US Patent					Assay Description The ability of a compound to inhibit PDE10 enzymatic activity can be demonstrated by any number of assays that are known in the art. The products of ...				US Patent US8933224 (2015) BindingDB Entry DOI: 10.7270/Q2WM1C35
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Rattus norvegicus (rat))	BDBM142550 (US8933224, 143 | US8933224, 144) Show SMILES Cc1nc([C@@H]2CCOC2)c2c(ncnn12)N1CCc2nc(C3CC3)n(C)c(=O)c2C1 |r| Show InChI InChI=1S/C21H25N7O2/c1-12-24-17(14-6-8-30-10-14)18-20(22-11-23-28(12)18)27-7-5-16-15(9-27)21(29)26(2)19(25-16)13-3-4-13/h11,13-14H,3-10H2,1-2H3/t14-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.106	n/a	n/a	n/a	n/a	7.5	n/a
Pfizer Inc. US Patent					Assay Description The ability of a compound to inhibit PDE10 enzymatic activity can be demonstrated by any number of assays that are known in the art. The products of ...				US Patent US8933224 (2015) BindingDB Entry DOI: 10.7270/Q2WM1C35
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM142451 (US8933224, 44) Show SMILES Cc1nc([C@@H]2CCOC2)c2c(ncnn12)N1CCc2nn(C)c(C3CC3)c2C1 |r| Show InChI InChI=1S/C20H25N7O/c1-12-23-17(14-6-8-28-10-14)19-20(21-11-22-27(12)19)26-7-5-16-15(9-26)18(13-3-4-13)25(2)24-16/h11,13-14H,3-10H2,1-2H3/t14-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.110	n/a	n/a	n/a	n/a	7.5	n/a
Pfizer Inc. US Patent					Assay Description The ability of a compound to inhibit PDE10 enzymatic activity can be demonstrated by any number of assays that are known in the art. The products of ...				US Patent US8933224 (2015) BindingDB Entry DOI: 10.7270/Q2WM1C35
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Rattus norvegicus (rat))	BDBM142442 (US8933224, 35) Show SMILES CCOc1nc(C)nc2CCN(Cc12)c1ncnn2c(C)nc([C@@H]3CCOC3)c12 |r| Show InChI InChI=1S/C20H25N7O2/c1-4-29-20-15-9-26(7-5-16(15)23-12(2)24-20)19-18-17(14-6-8-28-10-14)25-13(3)27(18)22-11-21-19/h11,14H,4-10H2,1-3H3/t14-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.123	n/a	n/a	n/a	n/a	7.5	n/a
Pfizer Inc. US Patent					Assay Description The ability of a compound to inhibit PDE10 enzymatic activity can be demonstrated by any number of assays that are known in the art. The products of ...				US Patent US8933224 (2015) BindingDB Entry DOI: 10.7270/Q2WM1C35
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Rattus norvegicus (rat))	BDBM142555 (US8933224, 148) Show SMILES CCOc1nc(nc2CCN(Cc12)c1ncnn2c(C)nc([C@@H]3CCOC3)c12)C1CC1 |r| Show InChI InChI=1S/C22H27N7O2/c1-3-31-22-16-10-28(8-6-17(16)26-20(27-22)14-4-5-14)21-19-18(15-7-9-30-11-15)25-13(2)29(19)24-12-23-21/h12,14-15H,3-11H2,1-2H3/t15-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.125	n/a	n/a	n/a	n/a	7.5	n/a
Pfizer Inc. US Patent					Assay Description The ability of a compound to inhibit PDE10 enzymatic activity can be demonstrated by any number of assays that are known in the art. The products of ...				US Patent US8933224 (2015) BindingDB Entry DOI: 10.7270/Q2WM1C35
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Rattus norvegicus (rat))	BDBM142559 (US8933224, 152) Show SMILES CNc1ccc2CN(CCc2n1)c1ncnn2c(C)nc([C@@H]3CCOC3)c12 |r| Show InChI InChI=1S/C19H23N7O/c1-12-23-17(14-6-8-27-10-14)18-19(21-11-22-26(12)18)25-7-5-15-13(9-25)3-4-16(20-2)24-15/h3-4,11,14H,5-10H2,1-2H3,(H,20,24)/t14-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<0.130	n/a	n/a	n/a	n/a	7.5	n/a
Pfizer Inc. US Patent					Assay Description The ability of a compound to inhibit PDE10 enzymatic activity can be demonstrated by any number of assays that are known in the art. The products of ...				US Patent US8933224 (2015) BindingDB Entry DOI: 10.7270/Q2WM1C35
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Rattus norvegicus (rat))	BDBM142493 (US8933224, 86) Show SMILES CC(C)c1nn(C)c2CCN(Cc12)c1ncnn2c(C)nc([C@@H]3CCOC3)c12 |r| Show InChI InChI=1S/C20H27N7O/c1-12(2)17-15-9-26(7-5-16(15)25(4)24-17)20-19-18(14-6-8-28-10-14)23-13(3)27(19)22-11-21-20/h11-12,14H,5-10H2,1-4H3/t14-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.132	n/a	n/a	n/a	n/a	7.5	n/a
Pfizer Inc. US Patent					Assay Description The ability of a compound to inhibit PDE10 enzymatic activity can be demonstrated by any number of assays that are known in the art. The products of ...				US Patent US8933224 (2015) BindingDB Entry DOI: 10.7270/Q2WM1C35
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Rattus norvegicus (rat))	BDBM142446 (US8933224, 173 | US8933224, 39) Show SMILES COc1nc(nc2CCN(Cc12)c1ncnn2c(C)nc([C@@H]3CCOC3)c12)C1CC1 |r| Show InChI InChI=1S/C21H25N7O2/c1-12-24-17(14-6-8-30-10-14)18-20(22-11-23-28(12)18)27-7-5-16-15(9-27)21(29-2)26-19(25-16)13-3-4-13/h11,13-14H,3-10H2,1-2H3/t14-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.136	n/a	n/a	n/a	n/a	7.5	n/a
Pfizer Inc. US Patent					Assay Description The ability of a compound to inhibit PDE10 enzymatic activity can be demonstrated by any number of assays that are known in the art. The products of ...				US Patent US8933224 (2015) BindingDB Entry DOI: 10.7270/Q2WM1C35
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Rattus norvegicus (rat))	BDBM142548 (US8933224, 141) Show SMILES Cc1nc([C@@H]2CCOC2)c2c(ncnn12)N1CCc2nc(nc(OC(F)F)c2C1)C1CC1 |r| Show InChI InChI=1S/C21H23F2N7O2/c1-11-26-16(13-5-7-31-9-13)17-19(24-10-25-30(11)17)29-6-4-15-14(8-29)20(32-21(22)23)28-18(27-15)12-2-3-12/h10,12-13,21H,2-9H2,1H3/t13-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.142	n/a	n/a	n/a	n/a	7.5	n/a
Pfizer Inc. US Patent					Assay Description The ability of a compound to inhibit PDE10 enzymatic activity can be demonstrated by any number of assays that are known in the art. The products of ...				US Patent US8933224 (2015) BindingDB Entry DOI: 10.7270/Q2WM1C35
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Rattus norvegicus (rat))	BDBM142561 (US8933224, 154) Show SMILES Cc1nc([C@@H]2CCOC2)c2c(ncnn12)N1CCc2nc(ccc2C1)C1CC1 |r| Show InChI InChI=1S/C21H24N6O/c1-13-24-19(16-7-9-28-11-16)20-21(22-12-23-27(13)20)26-8-6-18-15(10-26)4-5-17(25-18)14-2-3-14/h4-5,12,14,16H,2-3,6-11H2,1H3/t16-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.144	n/a	n/a	n/a	n/a	7.5	n/a
Pfizer Inc. US Patent					Assay Description The ability of a compound to inhibit PDE10 enzymatic activity can be demonstrated by any number of assays that are known in the art. The products of ...				US Patent US8933224 (2015) BindingDB Entry DOI: 10.7270/Q2WM1C35
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Rattus norvegicus (rat))	BDBM142425 (US8933224, 18) Show SMILES CCc1nn(C)c2CCN(Cc12)c1ncnn2c(C)nc([C@@H]3CCOC3)c12 |r| Show InChI InChI=1S/C19H25N7O/c1-4-15-14-9-25(7-5-16(14)24(3)23-15)19-18-17(13-6-8-27-10-13)22-12(2)26(18)21-11-20-19/h11,13H,4-10H2,1-3H3/t13-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.147	n/a	n/a	n/a	n/a	7.5	n/a
Pfizer Inc. US Patent					Assay Description The ability of a compound to inhibit PDE10 enzymatic activity can be demonstrated by any number of assays that are known in the art. The products of ...				US Patent US8933224 (2015) BindingDB Entry DOI: 10.7270/Q2WM1C35
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Rattus norvegicus (rat))	BDBM142519 (US8933224, 112) Show SMILES CCc1c2CN(CCc2nn1C)c1ncnn2c(C)nc(-c3ccccc3F)c12 Show InChI InChI=1S/C21H22FN7/c1-4-18-15-11-28(10-9-17(15)26-27(18)3)21-20-19(14-7-5-6-8-16(14)22)25-13(2)29(20)24-12-23-21/h5-8,12H,4,9-11H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.147	n/a	n/a	n/a	n/a	7.5	n/a
Pfizer Inc. US Patent					Assay Description The ability of a compound to inhibit PDE10 enzymatic activity can be demonstrated by any number of assays that are known in the art. The products of ...				US Patent US8933224 (2015) BindingDB Entry DOI: 10.7270/Q2WM1C35
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Rattus norvegicus (rat))	BDBM142568 (US8933224, 161) Show SMILES Cc1nc([C@@H]2CCOC2)c2c(ncnn12)N1CCc2cc(ncc2C1)C1CC1 |r| Show InChI InChI=1S/C21H24N6O/c1-13-25-19(16-5-7-28-11-16)20-21(23-12-24-27(13)20)26-6-4-15-8-18(14-2-3-14)22-9-17(15)10-26/h8-9,12,14,16H,2-7,10-11H2,1H3/t16-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.163	n/a	n/a	n/a	n/a	7.5	n/a
Pfizer Inc. US Patent					Assay Description The ability of a compound to inhibit PDE10 enzymatic activity can be demonstrated by any number of assays that are known in the art. The products of ...				US Patent US8933224 (2015) BindingDB Entry DOI: 10.7270/Q2WM1C35
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM142555 (US8933224, 148) Show SMILES CCOc1nc(nc2CCN(Cc12)c1ncnn2c(C)nc([C@@H]3CCOC3)c12)C1CC1 |r| Show InChI InChI=1S/C22H27N7O2/c1-3-31-22-16-10-28(8-6-17(16)26-20(27-22)14-4-5-14)21-19-18(15-7-9-30-11-15)25-13(2)29(19)24-12-23-21/h12,14-15H,3-11H2,1-2H3/t15-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.166	n/a	n/a	n/a	n/a	7.5	n/a
Pfizer Inc. US Patent					Assay Description The ability of a compound to inhibit PDE10 enzymatic activity can be demonstrated by any number of assays that are known in the art. The products of ...				US Patent US8933224 (2015) BindingDB Entry DOI: 10.7270/Q2WM1C35
					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50088373 (CHEBI:46295 | Vardenafil | cid_110634) Show SMILES CCCc1nc(C)c2n1[nH]c(nc2=O)-c1cc(ccc1OCC)S(=O)(=O)N1CCN(CC)CC1 Show InChI InChI=1S/C23H32N6O4S/c1-5-8-20-24-16(4)21-23(30)25-22(26-29(20)21)18-15-17(9-10-19(18)33-7-3)34(31,32)28-13-11-27(6-2)12-14-28/h9-10,15H,5-8,11-14H2,1-4H3,(H,25,26,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE PC cid PC sid PDB UniChem Similars	DrugBank PDB Article PubMed	n/a	n/a	0.170	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of PDE5A1 (unknwon origin) using [3H]cGMP as substrate after 30 mins by SPA				J Med Chem 61: 1001-1018 (2018) Article DOI: 10.1021/acs.jmedchem.7b01466 BindingDB Entry DOI: 10.7270/Q2ZS2ZZ4
					More data for this Ligand-Target Pair				3D Structure (crystal)
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Rattus norvegicus (rat))	BDBM142562 (US8933224, 155) Show SMILES Cc1nc([C@@H]2CCOC2)c2c(ncnn12)N1CCc2cccc(C)c2C1 |r| Show InChI InChI=1S/C20H23N5O/c1-13-4-3-5-15-6-8-24(10-17(13)15)20-19-18(16-7-9-26-11-16)23-14(2)25(19)22-12-21-20/h3-5,12,16H,6-11H2,1-2H3/t16-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.171	n/a	n/a	n/a	n/a	7.5	n/a
Pfizer Inc. US Patent					Assay Description The ability of a compound to inhibit PDE10 enzymatic activity can be demonstrated by any number of assays that are known in the art. The products of ...				US Patent US8933224 (2015) BindingDB Entry DOI: 10.7270/Q2WM1C35
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Rattus norvegicus (rat))	BDBM142444 (US8933224, 132 | US8933224, 37) Show SMILES COc1nc(C)nc2CCN(Cc12)c1ncnn2c(C)nc([C@@H]3CCOC3)c12 |r| Show InChI InChI=1S/C19H23N7O2/c1-11-22-15-4-6-25(8-14(15)19(23-11)27-3)18-17-16(13-5-7-28-9-13)24-12(2)26(17)21-10-20-18/h10,13H,4-9H2,1-3H3/t13-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.174	n/a	n/a	n/a	n/a	7.5	n/a
Pfizer Inc. US Patent					Assay Description The ability of a compound to inhibit PDE10 enzymatic activity can be demonstrated by any number of assays that are known in the art. The products of ...				US Patent US8933224 (2015) BindingDB Entry DOI: 10.7270/Q2WM1C35
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Rattus norvegicus (rat))	BDBM142593 (US8933224, 11) Show SMILES Cc1nc([C@@H]2CCOC2)c2c(ncnn12)N1CCc2nn(cc2C1)C1CC1 Show InChI InChI=1S/C19H23N7O/c1-12-22-17(13-5-7-27-10-13)18-19(20-11-21-26(12)18)24-6-4-16-14(8-24)9-25(23-16)15-2-3-15/h9,11,13,15H,2-8,10H2,1H3/t13-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.174	n/a	n/a	n/a	n/a	7.5	n/a
Pfizer Inc. US Patent					Assay Description The ability of a compound to inhibit PDE10 enzymatic activity can be demonstrated by any number of assays that are known in the art. The products of ...				US Patent US8933224 (2015) BindingDB Entry DOI: 10.7270/Q2WM1C35
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Rattus norvegicus (rat))	BDBM142448 (US8933224, 41) Show SMILES Cc1nc([C@@H]2CCOC2)c2c(ncnn12)N1CCc2nc(nc(C)c2C1)C1CC1 |r| Show InChI InChI=1S/C21H25N7O/c1-12-16-9-27(7-5-17(16)26-20(24-12)14-3-4-14)21-19-18(15-6-8-29-10-15)25-13(2)28(19)23-11-22-21/h11,14-15H,3-10H2,1-2H3/t15-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<0.175	n/a	n/a	n/a	n/a	7.5	n/a
Pfizer Inc. US Patent					Assay Description The ability of a compound to inhibit PDE10 enzymatic activity can be demonstrated by any number of assays that are known in the art. The products of ...				US Patent US8933224 (2015) BindingDB Entry DOI: 10.7270/Q2WM1C35
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Rattus norvegicus (rat))	BDBM142444 (US8933224, 132 | US8933224, 37) Show SMILES COc1nc(C)nc2CCN(Cc12)c1ncnn2c(C)nc([C@@H]3CCOC3)c12 |r| Show InChI InChI=1S/C19H23N7O2/c1-11-22-15-4-6-25(8-14(15)19(23-11)27-3)18-17-16(13-5-7-28-9-13)24-12(2)26(17)21-10-20-18/h10,13H,4-9H2,1-3H3/t13-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.177	n/a	n/a	n/a	n/a	7.5	n/a
Pfizer Inc. US Patent					Assay Description The ability of a compound to inhibit PDE10 enzymatic activity can be demonstrated by any number of assays that are known in the art. The products of ...				US Patent US8933224 (2015) BindingDB Entry DOI: 10.7270/Q2WM1C35
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM50485444 (CHEMBL2059813) Show SMILES NC(=O)[C@@H](CCC(F)(F)F)N(CC12CC(C1)(C2)c1ncon1)S(=O)(=O)c1ccc(Cl)cc1 |r| Show InChI InChI=1S/C19H20ClF3N4O4S/c20-12-1-3-13(4-2-12)32(29,30)27(14(15(24)28)5-6-19(21,22)23)10-17-7-18(8-17,9-17)16-25-11-31-26-16/h1-4,11,14H,5-10H2,(H2,24,28)/t14-,17?,18?/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.178	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of gamma secretase-mediated amyloid beta42 production in human H4 cells expressing human APP swedish mutant				J Med Chem 55: 3414-24 (2012) Article DOI: 10.1021/jm300094u BindingDB Entry DOI: 10.7270/Q23F4SHS
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM142492 (US8933224, 85) Show SMILES CC(C)c1nn(C)c2CCN(Cc12)c1ncnn2c(C)nc([C@H]3CCOC3)c12 |r| Show InChI InChI=1S/C20H27N7O/c1-12(2)17-15-9-26(7-5-16(15)25(4)24-17)20-19-18(14-6-8-28-10-14)23-13(3)27(19)22-11-21-20/h11-12,14H,5-10H2,1-4H3/t14-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.182	n/a	n/a	n/a	n/a	7.5	n/a
Pfizer Inc. US Patent					Assay Description The ability of a compound to inhibit PDE10 enzymatic activity can be demonstrated by any number of assays that are known in the art. The products of ...				US Patent US8933224 (2015) BindingDB Entry DOI: 10.7270/Q2WM1C35
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Rattus norvegicus (rat))	BDBM142446 (US8933224, 173 | US8933224, 39) Show SMILES COc1nc(nc2CCN(Cc12)c1ncnn2c(C)nc([C@@H]3CCOC3)c12)C1CC1 |r| Show InChI InChI=1S/C21H25N7O2/c1-12-24-17(14-6-8-30-10-14)18-20(22-11-23-28(12)18)27-7-5-16-15(9-27)21(29-2)26-19(25-16)13-3-4-13/h11,13-14H,3-10H2,1-2H3/t14-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.193	n/a	n/a	n/a	n/a	7.5	n/a
Pfizer Inc. US Patent					Assay Description The ability of a compound to inhibit PDE10 enzymatic activity can be demonstrated by any number of assays that are known in the art. The products of ...				US Patent US8933224 (2015) BindingDB Entry DOI: 10.7270/Q2WM1C35
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Rattus norvegicus (rat))	BDBM142594 (US8933224, 12) Show SMILES Cc1nc([C@@H]2CCOC2)c2c(ncnn12)N1CCc2c(C1)c(nn2C)C1CC1 Show InChI InChI=1S/C20H25N7O/c1-12-23-18(14-6-8-28-10-14)19-20(21-11-22-27(12)19)26-7-5-16-15(9-26)17(13-3-4-13)24-25(16)2/h11,13-14H,3-10H2,1-2H3/t14-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.194	n/a	n/a	n/a	n/a	7.5	n/a
Pfizer Inc. US Patent					Assay Description The ability of a compound to inhibit PDE10 enzymatic activity can be demonstrated by any number of assays that are known in the art. The products of ...				US Patent US8933224 (2015) BindingDB Entry DOI: 10.7270/Q2WM1C35
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Rattus norvegicus (rat))	BDBM142564 (US8933224, 157) Show SMILES Cc1nc([C@@H]2CCOC2)c2c(ncnn12)N1CCc2ccc(nc2C1)C(F)(F)F |r| Show InChI InChI=1S/C19H19F3N6O/c1-11-25-16(13-5-7-29-9-13)17-18(23-10-24-28(11)17)27-6-4-12-2-3-15(19(20,21)22)26-14(12)8-27/h2-3,10,13H,4-9H2,1H3/t13-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.196	n/a	n/a	n/a	n/a	7.5	n/a
Pfizer Inc. US Patent					Assay Description The ability of a compound to inhibit PDE10 enzymatic activity can be demonstrated by any number of assays that are known in the art. The products of ...				US Patent US8933224 (2015) BindingDB Entry DOI: 10.7270/Q2WM1C35
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Rattus norvegicus (rat))	BDBM142586 (US8933224, 4) Show SMILES COc1ccc2CCN(Cc2c1OCCF)c1ncnn2c(C)nc([C@@H]3CCOC3)c12 Show InChI InChI=1S/C22H26FN5O3/c1-14-26-19(16-6-9-30-12-16)20-22(24-13-25-28(14)20)27-8-5-15-3-4-18(29-2)21(17(15)11-27)31-10-7-23/h3-4,13,16H,5-12H2,1-2H3/t16-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.205	n/a	n/a	n/a	n/a	7.5	n/a
Pfizer Inc. US Patent					Assay Description The ability of a compound to inhibit PDE10 enzymatic activity can be demonstrated by any number of assays that are known in the art. The products of ...				US Patent US8933224 (2015) BindingDB Entry DOI: 10.7270/Q2WM1C35
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM142481 (US8933224, 74) Show SMILES Cc1nc([C@@H]2CCOC2)c2c(ncnn12)N1CCc2ccc(nc2C1)C1CC1 |r| Show InChI InChI=1S/C21H24N6O/c1-13-24-19(16-7-9-28-11-16)20-21(22-12-23-27(13)20)26-8-6-15-4-5-17(14-2-3-14)25-18(15)10-26/h4-5,12,14,16H,2-3,6-11H2,1H3/t16-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.211	n/a	n/a	n/a	n/a	7.5	n/a
Pfizer Inc. US Patent					Assay Description The ability of a compound to inhibit PDE10 enzymatic activity can be demonstrated by any number of assays that are known in the art. The products of ...				US Patent US8933224 (2015) BindingDB Entry DOI: 10.7270/Q2WM1C35
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM142550 (US8933224, 143 | US8933224, 144) Show SMILES Cc1nc([C@@H]2CCOC2)c2c(ncnn12)N1CCc2nc(C3CC3)n(C)c(=O)c2C1 |r| Show InChI InChI=1S/C21H25N7O2/c1-12-24-17(14-6-8-30-10-14)18-20(22-11-23-28(12)18)27-7-5-16-15(9-27)21(29)26(2)19(25-16)13-3-4-13/h11,13-14H,3-10H2,1-2H3/t14-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.219	n/a	n/a	n/a	n/a	7.5	n/a
Pfizer Inc. US Patent					Assay Description The ability of a compound to inhibit PDE10 enzymatic activity can be demonstrated by any number of assays that are known in the art. The products of ...				US Patent US8933224 (2015) BindingDB Entry DOI: 10.7270/Q2WM1C35
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM50458169 (Avagacestat | BMS 708163 | BMS-708163 | BMS-708163...) Show SMILES NC(=O)[C@@H](CCC(F)(F)F)N(Cc1ccc(cc1F)-c1ncon1)S(=O)(=O)c1ccc(Cl)cc1 |r| Show InChI InChI=1S/C20H17ClF4N4O4S/c21-14-3-5-15(6-4-14)34(31,32)29(17(18(26)30)7-8-20(23,24)25)10-13-2-1-12(9-16(13)22)19-27-11-33-28-19/h1-6,9,11,17H,7-8,10H2,(H2,26,30)/t17-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	0.225	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of gamma secretase-mediated amyloid beta42 production in human H4 cells expressing human APP swedish mutant				J Med Chem 55: 3414-24 (2012) Article DOI: 10.1021/jm300094u BindingDB Entry DOI: 10.7270/Q23F4SHS
					More data for this Ligand-Target Pair				3D Structure (crystal)
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Rattus norvegicus (rat))	BDBM142565 (US8933224, 158) Show SMILES Cc1nc([C@@H]2CCOC2)c2c(ncnn12)N1CCc2c(O)nc(nc2C1)C1CCCC1 |r| Show InChI InChI=1S/C22H27N7O2/c1-13-25-18(15-7-9-31-11-15)19-21(23-12-24-29(13)19)28-8-6-16-17(10-28)26-20(27-22(16)30)14-4-2-3-5-14/h12,14-15H,2-11H2,1H3,(H,26,27,30)/t15-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.227	n/a	n/a	n/a	n/a	7.5	n/a
Pfizer Inc. US Patent					Assay Description The ability of a compound to inhibit PDE10 enzymatic activity can be demonstrated by any number of assays that are known in the art. The products of ...				US Patent US8933224 (2015) BindingDB Entry DOI: 10.7270/Q2WM1C35
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Rattus norvegicus (rat))	BDBM142527 (US8933224, 120) Show SMILES CCc1c2CN(CCc2nn1C)c1ncnn2c(C)nc(-c3ccc(F)cc3Cl)c12 Show InChI InChI=1S/C21H21ClFN7/c1-4-18-15-10-29(8-7-17(15)27-28(18)3)21-20-19(14-6-5-13(23)9-16(14)22)26-12(2)30(20)25-11-24-21/h5-6,9,11H,4,7-8,10H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.233	n/a	n/a	n/a	n/a	7.5	n/a
Pfizer Inc. US Patent					Assay Description The ability of a compound to inhibit PDE10 enzymatic activity can be demonstrated by any number of assays that are known in the art. The products of ...				US Patent US8933224 (2015) BindingDB Entry DOI: 10.7270/Q2WM1C35
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Rattus norvegicus (rat))	BDBM142435 (US8933224, 28) Show SMILES COc1nccc2CCN(Cc12)c1ncnn2c(C)nc([C@@H]3CCOC3)c12 |r| Show InChI InChI=1S/C19H22N6O2/c1-12-23-16(14-5-8-27-10-14)17-18(21-11-22-25(12)17)24-7-4-13-3-6-20-19(26-2)15(13)9-24/h3,6,11,14H,4-5,7-10H2,1-2H3/t14-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.236	n/a	n/a	n/a	n/a	7.5	n/a
Pfizer Inc. US Patent					Assay Description The ability of a compound to inhibit PDE10 enzymatic activity can be demonstrated by any number of assays that are known in the art. The products of ...				US Patent US8933224 (2015) BindingDB Entry DOI: 10.7270/Q2WM1C35
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Rattus norvegicus (rat))	BDBM142424 (US8933224, 17) Show SMILES COc1ccc2CCN(Cc2c1OC)c1ncnn2c(C)nc([C@@H]3CCOC3)c12 |r| Show InChI InChI=1S/C21H25N5O3/c1-13-24-18(15-7-9-29-11-15)19-21(22-12-23-26(13)19)25-8-6-14-4-5-17(27-2)20(28-3)16(14)10-25/h4-5,12,15H,6-11H2,1-3H3/t15-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<0.240	n/a	n/a	n/a	n/a	7.5	n/a
Pfizer Inc. US Patent					Assay Description The ability of a compound to inhibit PDE10 enzymatic activity can be demonstrated by any number of assays that are known in the art. The products of ...				US Patent US8933224 (2015) BindingDB Entry DOI: 10.7270/Q2WM1C35
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Rattus norvegicus (rat))	BDBM142479 (US8933224, 72) Show SMILES Cc1nc([C@@H]2CCOC2)c2c(ncnn12)N1CCc2ccc(C)nc2C1 |r| Show InChI InChI=1S/C19H22N6O/c1-12-3-4-14-5-7-24(9-16(14)22-12)19-18-17(15-6-8-26-10-15)23-13(2)25(18)21-11-20-19/h3-4,11,15H,5-10H2,1-2H3/t15-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.255	n/a	n/a	n/a	n/a	7.5	n/a
Pfizer Inc. US Patent					Assay Description The ability of a compound to inhibit PDE10 enzymatic activity can be demonstrated by any number of assays that are known in the art. The products of ...				US Patent US8933224 (2015) BindingDB Entry DOI: 10.7270/Q2WM1C35
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM142594 (US8933224, 12) Show SMILES Cc1nc([C@@H]2CCOC2)c2c(ncnn12)N1CCc2c(C1)c(nn2C)C1CC1 Show InChI InChI=1S/C20H25N7O/c1-12-23-18(14-6-8-28-10-14)19-20(21-11-22-27(12)19)26-7-5-16-15(9-26)17(13-3-4-13)24-25(16)2/h11,13-14H,3-10H2,1-2H3/t14-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.257	n/a	n/a	n/a	n/a	7.5	n/a
Pfizer Inc. US Patent					Assay Description The ability of a compound to inhibit PDE10 enzymatic activity can be demonstrated by any number of assays that are known in the art. The products of ...				US Patent US8933224 (2015) BindingDB Entry DOI: 10.7270/Q2WM1C35
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM142593 (US8933224, 11) Show SMILES Cc1nc([C@@H]2CCOC2)c2c(ncnn12)N1CCc2nn(cc2C1)C1CC1 Show InChI InChI=1S/C19H23N7O/c1-12-22-17(13-5-7-27-10-13)18-19(20-11-21-26(12)18)24-6-4-16-14(8-24)9-25(23-16)15-2-3-15/h9,11,13,15H,2-8,10H2,1H3/t13-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.265	n/a	n/a	n/a	n/a	7.5	n/a
Pfizer Inc. US Patent					Assay Description The ability of a compound to inhibit PDE10 enzymatic activity can be demonstrated by any number of assays that are known in the art. The products of ...				US Patent US8933224 (2015) BindingDB Entry DOI: 10.7270/Q2WM1C35
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Rattus norvegicus (rat))	BDBM142543 (US8933224, 136) Show SMILES CCc1nc(nc2CCN(Cc12)c1ncnn2c(C)nc(-c3ccccc3F)c12)C1CC1 Show InChI InChI=1S/C24H24FN7/c1-3-19-17-12-31(11-10-20(17)30-23(29-19)15-8-9-15)24-22-21(16-6-4-5-7-18(16)25)28-14(2)32(22)27-13-26-24/h4-7,13,15H,3,8-12H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.265	n/a	n/a	n/a	n/a	7.5	n/a
Pfizer Inc. US Patent					Assay Description The ability of a compound to inhibit PDE10 enzymatic activity can be demonstrated by any number of assays that are known in the art. The products of ...				US Patent US8933224 (2015) BindingDB Entry DOI: 10.7270/Q2WM1C35
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Rattus norvegicus (rat))	BDBM142546 (US8933224, 139) Show SMILES Cc1nc([C@@H]2CCOC2)c2c(ncnn12)N1CCc2nc(C)ccc2C1 |r| Show InChI InChI=1S/C19H22N6O/c1-12-3-4-14-9-24(7-5-16(14)22-12)19-18-17(15-6-8-26-10-15)23-13(2)25(18)21-11-20-19/h3-4,11,15H,5-10H2,1-2H3/t15-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.270	n/a	n/a	n/a	n/a	7.5	n/a
Pfizer Inc. US Patent					Assay Description The ability of a compound to inhibit PDE10 enzymatic activity can be demonstrated by any number of assays that are known in the art. The products of ...				US Patent US8933224 (2015) BindingDB Entry DOI: 10.7270/Q2WM1C35
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM142442 (US8933224, 35) Show SMILES CCOc1nc(C)nc2CCN(Cc12)c1ncnn2c(C)nc([C@@H]3CCOC3)c12 |r| Show InChI InChI=1S/C20H25N7O2/c1-4-29-20-15-9-26(7-5-16(15)23-12(2)24-20)19-18-17(14-6-8-28-10-14)25-13(3)27(18)22-11-21-19/h11,14H,4-10H2,1-3H3/t14-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.275	n/a	n/a	n/a	n/a	7.5	n/a
Pfizer Inc. US Patent					Assay Description The ability of a compound to inhibit PDE10 enzymatic activity can be demonstrated by any number of assays that are known in the art. The products of ...				US Patent US8933224 (2015) BindingDB Entry DOI: 10.7270/Q2WM1C35
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM142444 (US8933224, 132 | US8933224, 37) Show SMILES COc1nc(C)nc2CCN(Cc12)c1ncnn2c(C)nc([C@@H]3CCOC3)c12 |r| Show InChI InChI=1S/C19H23N7O2/c1-11-22-15-4-6-25(8-14(15)19(23-11)27-3)18-17-16(13-5-7-28-9-13)24-12(2)26(17)21-10-20-18/h10,13H,4-9H2,1-3H3/t13-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.277	n/a	n/a	n/a	n/a	7.5	n/a
Pfizer Inc. US Patent					Assay Description The ability of a compound to inhibit PDE10 enzymatic activity can be demonstrated by any number of assays that are known in the art. The products of ...				US Patent US8933224 (2015) BindingDB Entry DOI: 10.7270/Q2WM1C35
					More data for this Ligand-Target Pair

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