Compile Data Set for Download or QSAR

Found 79 hits with Last Name = 'lee' and Initial = 'iy'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM138212 (US8871778, 198) Show SMILES Cc1nn(cc1CN1CC[C@@H](O)C1)-c1cccc(Nc2ccc3n(C)cc(C(=O)C(F)(F)F)c3c2)n1 |r| Show InChI InChI=1S/C25H25F3N6O2/c1-15-16(11-33-9-8-18(35)13-33)12-34(31-15)23-5-3-4-22(30-23)29-17-6-7-21-19(10-17)20(14-32(21)2)24(36)25(26,27)28/h3-7,10,12,14,18,35H,8-9,11,13H2,1-2H3,(H,29,30)/t18-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.100	n/a	n/a	n/a	n/a	n/a	25
Genosco; Oscotec, Inc. US Patent					Assay Description Compounds of the invention were initially diluted to 10 mM in 100% DMSO (CALBIOCHEM) for storage and made into kinase buffer solution to create a com...				US Patent US8871778 (2014) BindingDB Entry DOI: 10.7270/Q2X065R6
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM138211 (US8871778, 190) Show SMILES Cc1nn(cc1CN1CC[C@@H](O)C1)-c1ccnc(Nc2ccc3n(C)cc(C(=O)C4CC4)c3c2)n1 |r| Show InChI InChI=1S/C26H29N7O2/c1-16-18(12-32-10-8-20(34)14-32)13-33(30-16)24-7-9-27-26(29-24)28-19-5-6-23-21(11-19)22(15-31(23)2)25(35)17-3-4-17/h5-7,9,11,13,15,17,20,34H,3-4,8,10,12,14H2,1-2H3,(H,27,28,29)/t20-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.100	n/a	n/a	n/a	n/a	n/a	25
Genosco; Oscotec, Inc. US Patent					Assay Description Compounds of the invention were initially diluted to 10 mM in 100% DMSO (CALBIOCHEM) for storage and made into kinase buffer solution to create a com...				US Patent US8871778 (2014) BindingDB Entry DOI: 10.7270/Q2X065R6
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM138217 (US8871778, 251) Show SMILES CO[C@@H]1CN(Cc2cn(nc2C)-c2ccnc(Nc3ccc4n(C)c(C)c(Cl)c4c3)n2)C[C@@H]1O |r| Show InChI InChI=1S/C24H28ClN7O2/c1-14-16(10-31-12-20(33)21(13-31)34-4)11-32(29-14)22-7-8-26-24(28-22)27-17-5-6-19-18(9-17)23(25)15(2)30(19)3/h5-9,11,20-21,33H,10,12-13H2,1-4H3,(H,26,27,28)/t20-,21+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.600	n/a	n/a	n/a	n/a	n/a	25
Genosco; Oscotec, Inc. US Patent					Assay Description Compounds of the invention were initially diluted to 10 mM in 100% DMSO (CALBIOCHEM) for storage and made into kinase buffer solution to create a com...				US Patent US8871778 (2014) BindingDB Entry DOI: 10.7270/Q2X065R6
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM138219 (US8871778, 255) Show SMILES Cc1nn(cc1CN1C[C@H](O)[C@H](O)C1)-c1ccnc(Nc2ccc3n(C)nc(c3c2)S(C)(=O)=O)n1 |r| Show InChI InChI=1S/C22H26N8O4S/c1-13-14(9-29-11-18(31)19(32)12-29)10-30(26-13)20-6-7-23-22(25-20)24-15-4-5-17-16(8-15)21(27-28(17)2)35(3,33)34/h4-8,10,18-19,31-32H,9,11-12H2,1-3H3,(H,23,24,25)/t18-,19+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.700	n/a	n/a	n/a	n/a	n/a	25
Genosco; Oscotec, Inc. US Patent					Assay Description Compounds of the invention were initially diluted to 10 mM in 100% DMSO (CALBIOCHEM) for storage and made into kinase buffer solution to create a com...				US Patent US8871778 (2014) BindingDB Entry DOI: 10.7270/Q2X065R6
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM138210 (US8871778, 189) Show SMILES Cc1nn(cc1CN1CC[C@@H](O)C1)-c1ccnc(Nc2ccc3n(C)c(C)c(Cl)c3c2)n1 |r| Show InChI InChI=1S/C23H26ClN7O/c1-14-16(11-30-9-7-18(32)13-30)12-31(28-14)21-6-8-25-23(27-21)26-17-4-5-20-19(10-17)22(24)15(2)29(20)3/h4-6,8,10,12,18,32H,7,9,11,13H2,1-3H3,(H,25,26,27)/t18-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	25
Genosco; Oscotec, Inc. US Patent					Assay Description Compounds of the invention were initially diluted to 10 mM in 100% DMSO (CALBIOCHEM) for storage and made into kinase buffer solution to create a com...				US Patent US8871778 (2014) BindingDB Entry DOI: 10.7270/Q2X065R6
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM138200 (US8871778, 141) Show SMILES Cc1nn(cc1CN1CC(O)C1)-c1ccnc(Nc2ccc3n(C)c(C)c(Cl)c3c2)n1 Show InChI InChI=1S/C22H24ClN7O/c1-13-15(9-29-11-17(31)12-29)10-30(27-13)20-6-7-24-22(26-20)25-16-4-5-19-18(8-16)21(23)14(2)28(19)3/h4-8,10,17,31H,9,11-12H2,1-3H3,(H,24,25,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid PDB UniChem Similars	PDB US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	25
Genosco; Oscotec, Inc. US Patent					Assay Description Compounds of the invention were initially diluted to 10 mM in 100% DMSO (CALBIOCHEM) for storage and made into kinase buffer solution to create a com...				US Patent US8871778 (2014) BindingDB Entry DOI: 10.7270/Q2X065R6
					More data for this Ligand-Target Pair				3D Structure (crystal)
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM138207 (US8871778, 176) Show SMILES Cc1nn(cc1CN1CC(O)C1)-c1nc(Nc2ccc3n(C)c(C)c(Cl)c3c2)ncc1F Show InChI InChI=1S/C22H23ClFN7O/c1-12-14(8-30-10-16(32)11-30)9-31(28-12)21-18(24)7-25-22(27-21)26-15-4-5-19-17(6-15)20(23)13(2)29(19)3/h4-7,9,16,32H,8,10-11H2,1-3H3,(H,25,26,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	25
Genosco; Oscotec, Inc. US Patent					Assay Description Compounds of the invention were initially diluted to 10 mM in 100% DMSO (CALBIOCHEM) for storage and made into kinase buffer solution to create a com...				US Patent US8871778 (2014) BindingDB Entry DOI: 10.7270/Q2X065R6
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM138220 (US8871778, 258) Show SMILES CCCn1c(C)c(Cl)c2cc(Nc3nccc(n3)-n3cc(CN4CC(O)C4)c(C)n3)ccc12 Show InChI InChI=1S/C24H28ClN7O/c1-4-9-31-16(3)23(25)20-10-18(5-6-21(20)31)27-24-26-8-7-22(28-24)32-12-17(15(2)29-32)11-30-13-19(33)14-30/h5-8,10,12,19,33H,4,9,11,13-14H2,1-3H3,(H,26,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a	25
Genosco; Oscotec, Inc. US Patent					Assay Description Compounds of the invention were initially diluted to 10 mM in 100% DMSO (CALBIOCHEM) for storage and made into kinase buffer solution to create a com...				US Patent US8871778 (2014) BindingDB Entry DOI: 10.7270/Q2X065R6
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM138202 (US8871778, 152) Show SMILES CC(=O)c1cn(C)c2ccc(Nc3nccc(n3)-n3cc(CN4CC(O)C4)c(C)n3)cc12 Show InChI InChI=1S/C23H25N7O2/c1-14-16(9-29-11-18(32)12-29)10-30(27-14)22-6-7-24-23(26-22)25-17-4-5-21-19(8-17)20(15(2)31)13-28(21)3/h4-8,10,13,18,32H,9,11-12H2,1-3H3,(H,24,25,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.30	n/a	n/a	n/a	n/a	n/a	25
Genosco; Oscotec, Inc. US Patent					Assay Description Compounds of the invention were initially diluted to 10 mM in 100% DMSO (CALBIOCHEM) for storage and made into kinase buffer solution to create a com...				US Patent US8871778 (2014) BindingDB Entry DOI: 10.7270/Q2X065R6
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM138213 (US8871778, 201) Show SMILES CC(=O)c1c[nH]c2ccc(Nc3nccc(n3)-n3cc(CN4CC(O)C4)c(C)n3)cc12 Show InChI InChI=1S/C22H23N7O2/c1-13-15(9-28-11-17(31)12-28)10-29(27-13)21-5-6-23-22(26-21)25-16-3-4-20-18(7-16)19(8-24-20)14(2)30/h3-8,10,17,24,31H,9,11-12H2,1-2H3,(H,23,25,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.30	n/a	n/a	n/a	n/a	n/a	25
Genosco; Oscotec, Inc. US Patent					Assay Description Compounds of the invention were initially diluted to 10 mM in 100% DMSO (CALBIOCHEM) for storage and made into kinase buffer solution to create a com...				US Patent US8871778 (2014) BindingDB Entry DOI: 10.7270/Q2X065R6
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM138209 (US8871778, 182) Show SMILES Cc1cn(cc1CN1CC(O)C1)-c1nc(Nc2ccc3n(C)nc(Cl)c3c2)ncc1F Show InChI InChI=1S/C21H21ClFN7O/c1-12-7-30(9-13(12)8-29-10-15(31)11-29)20-17(23)6-24-21(26-20)25-14-3-4-18-16(5-14)19(22)27-28(18)2/h3-7,9,15,31H,8,10-11H2,1-2H3,(H,24,25,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.5	n/a	n/a	n/a	n/a	n/a	25
Genosco; Oscotec, Inc. US Patent					Assay Description Compounds of the invention were initially diluted to 10 mM in 100% DMSO (CALBIOCHEM) for storage and made into kinase buffer solution to create a com...				US Patent US8871778 (2014) BindingDB Entry DOI: 10.7270/Q2X065R6
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM138201 (US8871778, 144) Show SMILES Cc1nn(cc1CN1CC(O)C1)-c1ccnc(Nc2ccc3n(C)cc(Cl)c3c2)n1 Show InChI InChI=1S/C21H22ClN7O/c1-13-14(8-28-10-16(30)11-28)9-29(26-13)20-5-6-23-21(25-20)24-15-3-4-19-17(7-15)18(22)12-27(19)2/h3-7,9,12,16,30H,8,10-11H2,1-2H3,(H,23,24,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.80	n/a	n/a	n/a	n/a	n/a	25
Genosco; Oscotec, Inc. US Patent					Assay Description Compounds of the invention were initially diluted to 10 mM in 100% DMSO (CALBIOCHEM) for storage and made into kinase buffer solution to create a com...				US Patent US8871778 (2014) BindingDB Entry DOI: 10.7270/Q2X065R6
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM138208 (US8871778, 180) Show SMILES Cc1nn(cc1CN1CC(O)C1)-c1ccnc(Nc2ccc3n(C)cc(-c4nccs4)c3c2)n1 Show InChI InChI=1S/C24H24N8OS/c1-15-16(10-31-12-18(33)13-31)11-32(29-15)22-5-6-26-24(28-22)27-17-3-4-21-19(9-17)20(14-30(21)2)23-25-7-8-34-23/h3-9,11,14,18,33H,10,12-13H2,1-2H3,(H,26,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.10	n/a	n/a	n/a	n/a	n/a	25
Genosco; Oscotec, Inc. US Patent					Assay Description Compounds of the invention were initially diluted to 10 mM in 100% DMSO (CALBIOCHEM) for storage and made into kinase buffer solution to create a com...				US Patent US8871778 (2014) BindingDB Entry DOI: 10.7270/Q2X065R6
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM196801 (US9212178, 30) Show SMILES Cn1cc(C(=O)C2CC2)c2cc(Nc3nccc(n3)-n3cc(CN4C[C@H](O)CO4)cn3)ccc12 |r| Show InChI InChI=1S/C24H25N7O3/c1-29-13-20(23(33)16-2-3-16)19-8-17(4-5-21(19)29)27-24-25-7-6-22(28-24)31-11-15(9-26-31)10-30-12-18(32)14-34-30/h4-9,11,13,16,18,32H,2-3,10,12,14H2,1H3,(H,25,27,28)/t18-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.46	n/a	n/a	n/a	n/a	n/a	25
Genosco; Oscotec, Inc. US Patent					Assay Description Compounds of the invention were initially diluted to 10 mM in 100% DMSO (CALBIOCHEM) for storage and made into kinase buffer solution to create a com...				US Patent US9212178 (2015) BindingDB Entry DOI: 10.7270/Q2X9294C
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM196774 (US9212178, 3) Show SMILES Cc1nn(cc1CN1C[C@H](O)CO1)-c1ccnc(Nc2ccc3n(C)cc(C(=O)C(F)(F)F)c3c2)n1 |r| Show InChI InChI=1S/C23H22F3N7O3/c1-13-14(8-32-10-16(34)12-36-32)9-33(30-13)20-5-6-27-22(29-20)28-15-3-4-19-17(7-15)18(11-31(19)2)21(35)23(24,25)26/h3-7,9,11,16,34H,8,10,12H2,1-2H3,(H,27,28,29)/t16-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.82	n/a	n/a	n/a	n/a	n/a	25
Genosco; Oscotec, Inc. US Patent					Assay Description Compounds of the invention were initially diluted to 10 mM in 100% DMSO (CALBIOCHEM) for storage and made into kinase buffer solution to create a com...				US Patent US9212178 (2015) BindingDB Entry DOI: 10.7270/Q2X9294C
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM196786 (US9212178, 15) Show SMILES Cc1nn(cc1CN1C[C@H](O)CO1)-c1ccnc(Nc2ccc3n(CC(F)(F)F)cc(C(=O)C4CC4)c3c2)n1 |r| Show InChI InChI=1S/C26H26F3N7O3/c1-15-17(9-35-11-19(37)13-39-35)10-36(33-15)23-6-7-30-25(32-23)31-18-4-5-22-20(8-18)21(24(38)16-2-3-16)12-34(22)14-26(27,28)29/h4-8,10,12,16,19,37H,2-3,9,11,13-14H2,1H3,(H,30,31,32)/t19-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.98	n/a	n/a	n/a	n/a	n/a	25
Genosco; Oscotec, Inc. US Patent					Assay Description Compounds of the invention were initially diluted to 10 mM in 100% DMSO (CALBIOCHEM) for storage and made into kinase buffer solution to create a com...				US Patent US9212178 (2015) BindingDB Entry DOI: 10.7270/Q2X9294C
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM196794 (US9212178, 23 | US9212178, 24) Show SMILES Cc1nn(cc1CN1C[C@H](O)CO1)-c1ccnc(Nc2ccc3n(CCF)cc(C(=O)C4CC4)c3c2)n1 |r| Show InChI InChI=1S/C26H28FN7O3/c1-16-18(11-33-13-20(35)15-37-33)12-34(31-16)24-6-8-28-26(30-24)29-19-4-5-23-21(10-19)22(14-32(23)9-7-27)25(36)17-2-3-17/h4-6,8,10,12,14,17,20,35H,2-3,7,9,11,13,15H2,1H3,(H,28,29,30)/t20-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.10	n/a	n/a	n/a	n/a	n/a	25
Genosco; Oscotec, Inc. US Patent					Assay Description Compounds of the invention were initially diluted to 10 mM in 100% DMSO (CALBIOCHEM) for storage and made into kinase buffer solution to create a com...				US Patent US9212178 (2015) BindingDB Entry DOI: 10.7270/Q2X9294C
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM196803 (US9212178, 32) Show SMILES O[C@@H]1CON(Cc2cnn(c2)-c2ccnc(Nc3ccc4n(CCF)cc(C(=O)C5CC5)c4c3)n2)C1 |r| Show InChI InChI=1S/C25H26FN7O3/c26-6-8-31-14-21(24(35)17-1-2-17)20-9-18(3-4-22(20)31)29-25-27-7-5-23(30-25)33-12-16(10-28-33)11-32-13-19(34)15-36-32/h3-5,7,9-10,12,14,17,19,34H,1-2,6,8,11,13,15H2,(H,27,29,30)/t19-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.52	n/a	n/a	n/a	n/a	n/a	25
Genosco; Oscotec, Inc. US Patent					Assay Description Compounds of the invention were initially diluted to 10 mM in 100% DMSO (CALBIOCHEM) for storage and made into kinase buffer solution to create a com...				US Patent US9212178 (2015) BindingDB Entry DOI: 10.7270/Q2X9294C
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM196794 (US9212178, 23 | US9212178, 24) Show SMILES Cc1nn(cc1CN1C[C@H](O)CO1)-c1ccnc(Nc2ccc3n(CCF)cc(C(=O)C4CC4)c3c2)n1 |r| Show InChI InChI=1S/C26H28FN7O3/c1-16-18(11-33-13-20(35)15-37-33)12-34(31-16)24-6-8-28-26(30-24)29-19-4-5-23-21(10-19)22(14-32(23)9-7-27)25(36)17-2-3-17/h4-6,8,10,12,14,17,20,35H,2-3,7,9,11,13,15H2,1H3,(H,28,29,30)/t20-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.71	n/a	n/a	n/a	n/a	n/a	25
Genosco; Oscotec, Inc. US Patent					Assay Description Compounds of the invention were initially diluted to 10 mM in 100% DMSO (CALBIOCHEM) for storage and made into kinase buffer solution to create a com...				US Patent US9212178 (2015) BindingDB Entry DOI: 10.7270/Q2X9294C
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM196777 (US9212178, 29 | US9212178, 6) Show SMILES CCn1cc(C(=O)C2CC2)c2cc(Nc3nccc(n3)-n3cc(CN4C[C@H](O)CO4)c(C)n3)ccc12 |r| Show InChI InChI=1S/C26H29N7O3/c1-3-31-14-22(25(35)17-4-5-17)21-10-19(6-7-23(21)31)28-26-27-9-8-24(29-26)33-12-18(16(2)30-33)11-32-13-20(34)15-36-32/h6-10,12,14,17,20,34H,3-5,11,13,15H2,1-2H3,(H,27,28,29)/t20-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.69	n/a	n/a	n/a	n/a	n/a	25
Genosco; Oscotec, Inc. US Patent					Assay Description Compounds of the invention were initially diluted to 10 mM in 100% DMSO (CALBIOCHEM) for storage and made into kinase buffer solution to create a com...				US Patent US9212178 (2015) BindingDB Entry DOI: 10.7270/Q2X9294C
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM196804 (US9212178, 33) Show SMILES O[C@@H]1CON(Cc2cnn(c2)-c2ccnc(Nc3ccc4n(CC(F)F)cc(C(=O)C5CC5)c4c3)n2)C1 |r| Show InChI InChI=1S/C25H25F2N7O3/c26-22(27)13-32-12-20(24(36)16-1-2-16)19-7-17(3-4-21(19)32)30-25-28-6-5-23(31-25)34-10-15(8-29-34)9-33-11-18(35)14-37-33/h3-8,10,12,16,18,22,35H,1-2,9,11,13-14H2,(H,28,30,31)/t18-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.34	n/a	n/a	n/a	n/a	n/a	25
Genosco; Oscotec, Inc. US Patent					Assay Description Compounds of the invention were initially diluted to 10 mM in 100% DMSO (CALBIOCHEM) for storage and made into kinase buffer solution to create a com...				US Patent US9212178 (2015) BindingDB Entry DOI: 10.7270/Q2X9294C
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM196805 (US9212178, 34) Show SMILES O[C@@H]1CON(Cc2cnn(c2)-c2ccnc(Nc3ccc4n(CC(F)(F)F)cc(C(=O)C5CC5)c4c3)n2)C1 |r| Show InChI InChI=1S/C25H24F3N7O3/c26-25(27,28)14-33-12-20(23(37)16-1-2-16)19-7-17(3-4-21(19)33)31-24-29-6-5-22(32-24)35-10-15(8-30-35)9-34-11-18(36)13-38-34/h3-8,10,12,16,18,36H,1-2,9,11,13-14H2,(H,29,31,32)/t18-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.80	n/a	n/a	n/a	n/a	n/a	25
Genosco; Oscotec, Inc. US Patent					Assay Description Compounds of the invention were initially diluted to 10 mM in 100% DMSO (CALBIOCHEM) for storage and made into kinase buffer solution to create a com...				US Patent US9212178 (2015) BindingDB Entry DOI: 10.7270/Q2X9294C
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM196796 (US9212178, 25) Show SMILES CCn1cc(C(=O)C2CC2)c2cc(Nc3nccc(n3)-n3cc(CN4C[C@H](O)CO4)c(n3)C3CC3)ccc12 |r| Show InChI InChI=1S/C28H31N7O3/c1-2-33-15-23(27(37)18-5-6-18)22-11-20(7-8-24(22)33)30-28-29-10-9-25(31-28)35-13-19(26(32-35)17-3-4-17)12-34-14-21(36)16-38-34/h7-11,13,15,17-18,21,36H,2-6,12,14,16H2,1H3,(H,29,30,31)/t21-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.85	n/a	n/a	n/a	n/a	n/a	25
Genosco; Oscotec, Inc. US Patent					Assay Description Compounds of the invention were initially diluted to 10 mM in 100% DMSO (CALBIOCHEM) for storage and made into kinase buffer solution to create a com...				US Patent US9212178 (2015) BindingDB Entry DOI: 10.7270/Q2X9294C
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM196798 (US9212178, 27) Show SMILES Cc1nn(cc1CN1C[C@H](O)CO1)-c1ccnc(Nc2ccc3n(cc(C(=O)C4CC4)c3c2)S(C)(=O)=O)n1 |r| Show InChI InChI=1S/C25H27N7O5S/c1-15-17(10-30-12-19(33)14-37-30)11-31(29-15)23-7-8-26-25(28-23)27-18-5-6-22-20(9-18)21(24(34)16-3-4-16)13-32(22)38(2,35)36/h5-9,11,13,16,19,33H,3-4,10,12,14H2,1-2H3,(H,26,27,28)/t19-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.89	n/a	n/a	n/a	n/a	n/a	25
Genosco; Oscotec, Inc. US Patent					Assay Description Compounds of the invention were initially diluted to 10 mM in 100% DMSO (CALBIOCHEM) for storage and made into kinase buffer solution to create a com...				US Patent US9212178 (2015) BindingDB Entry DOI: 10.7270/Q2X9294C
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM196772 (US9212178, 1) Show SMILES Cc1nn(cc1CN1C[C@H](O)CO1)-c1ccnc(Nc2ccc3n(C)cc(C(=O)C4CC4)c3c2)n1 |r| Show InChI InChI=1S/C25H27N7O3/c1-15-17(10-31-12-19(33)14-35-31)11-32(29-15)23-7-8-26-25(28-23)27-18-5-6-22-20(9-18)21(13-30(22)2)24(34)16-3-4-16/h5-9,11,13,16,19,33H,3-4,10,12,14H2,1-2H3,(H,26,27,28)/t19-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	US Patent	n/a	n/a	6.15	n/a	n/a	n/a	n/a	n/a	25
Genosco; Oscotec, Inc. US Patent					Assay Description Compounds of the invention were initially diluted to 10 mM in 100% DMSO (CALBIOCHEM) for storage and made into kinase buffer solution to create a com...				US Patent US9212178 (2015) BindingDB Entry DOI: 10.7270/Q2X9294C
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM196782 (US9212178, 11) Show SMILES CCn1cc(C(=O)C2CC2)c2cc(Nc3nccc(n3)-n3cc(CN4C[C@@H](O)CO4)c(C)n3)ccc12 |r| Show InChI InChI=1S/C26H29N7O3/c1-3-31-14-22(25(35)17-4-5-17)21-10-19(6-7-23(21)31)28-26-27-9-8-24(29-26)33-12-18(16(2)30-33)11-32-13-20(34)15-36-32/h6-10,12,14,17,20,34H,3-5,11,13,15H2,1-2H3,(H,27,28,29)/t20-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6.28	n/a	n/a	n/a	n/a	n/a	25
Genosco; Oscotec, Inc. US Patent					Assay Description Compounds of the invention were initially diluted to 10 mM in 100% DMSO (CALBIOCHEM) for storage and made into kinase buffer solution to create a com...				US Patent US9212178 (2015) BindingDB Entry DOI: 10.7270/Q2X9294C
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM138215 (US8871778, 235) Show SMILES COC[C@@H]1C[C@@H](O)CN1Cc1cn(nc1C)-c1ccnc(Nc2ccc3n(C)c(C)c(Cl)c3c2)n1 |r| Show InChI InChI=1S/C25H30ClN7O2/c1-15-17(11-32-13-20(34)10-19(32)14-35-4)12-33(30-15)23-7-8-27-25(29-23)28-18-5-6-22-21(9-18)24(26)16(2)31(22)3/h5-9,12,19-20,34H,10-11,13-14H2,1-4H3,(H,27,28,29)/t19-,20+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	6.60	n/a	n/a	n/a	n/a	n/a	25
Genosco; Oscotec, Inc. US Patent					Assay Description Compounds of the invention were initially diluted to 10 mM in 100% DMSO (CALBIOCHEM) for storage and made into kinase buffer solution to create a com...				US Patent US8871778 (2014) BindingDB Entry DOI: 10.7270/Q2X065R6
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM196779 (US9212178, 8) Show SMILES CC(C)n1cc(C(=O)C2CC2)c2cc(Nc3nccc(n3)-n3cc(CN4C[C@H](O)CO4)c(C)n3)ccc12 |r| Show InChI InChI=1S/C27H31N7O3/c1-16(2)33-14-23(26(36)18-4-5-18)22-10-20(6-7-24(22)33)29-27-28-9-8-25(30-27)34-12-19(17(3)31-34)11-32-13-21(35)15-37-32/h6-10,12,14,16,18,21,35H,4-5,11,13,15H2,1-3H3,(H,28,29,30)/t21-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7.37	n/a	n/a	n/a	n/a	n/a	25
Genosco; Oscotec, Inc. US Patent					Assay Description Compounds of the invention were initially diluted to 10 mM in 100% DMSO (CALBIOCHEM) for storage and made into kinase buffer solution to create a com...				US Patent US9212178 (2015) BindingDB Entry DOI: 10.7270/Q2X9294C
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM196778 (US9212178, 7) Show SMILES Cc1nn(cc1CN1C[C@H](O)CO1)-c1ccnc(Nc2ccc3[nH]cc(C(=O)C(F)(F)F)c3c2)n1 |r| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	8.28	n/a	n/a	n/a	n/a	n/a	25
Genosco; Oscotec, Inc. US Patent					Assay Description Compounds of the invention were initially diluted to 10 mM in 100% DMSO (CALBIOCHEM) for storage and made into kinase buffer solution to create a com...				US Patent US9212178 (2015) BindingDB Entry DOI: 10.7270/Q2X9294C
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM196773 (US9212178, 2) Show SMILES CC(C)C(=O)c1cn(C)c2ccc(Nc3nccc(n3)-n3cc(CN4C[C@H](O)CO4)c(C)n3)cc12 |r| Show InChI InChI=1S/C25H29N7O3/c1-15(2)24(34)21-13-30(4)22-6-5-18(9-20(21)22)27-25-26-8-7-23(28-25)32-11-17(16(3)29-32)10-31-12-19(33)14-35-31/h5-9,11,13,15,19,33H,10,12,14H2,1-4H3,(H,26,27,28)/t19-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	8.63	n/a	n/a	n/a	n/a	n/a	25
Genosco; Oscotec, Inc. US Patent					Assay Description Compounds of the invention were initially diluted to 10 mM in 100% DMSO (CALBIOCHEM) for storage and made into kinase buffer solution to create a com...				US Patent US9212178 (2015) BindingDB Entry DOI: 10.7270/Q2X9294C
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM196775 (US9212178, 4) Show SMILES Cc1nn(cc1CN1C[C@H](O)CO1)-c1ccnc(Nc2ccc3n(C)cc(C(=O)C(F)F)c3c2)n1 |r| Show InChI InChI=1S/C23H23F2N7O3/c1-13-14(8-31-10-16(33)12-35-31)9-32(29-13)20-5-6-26-23(28-20)27-15-3-4-19-17(7-15)18(11-30(19)2)21(34)22(24)25/h3-7,9,11,16,22,33H,8,10,12H2,1-2H3,(H,26,27,28)/t16-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	9.42	n/a	n/a	n/a	n/a	n/a	25
Genosco; Oscotec, Inc. US Patent					Assay Description Compounds of the invention were initially diluted to 10 mM in 100% DMSO (CALBIOCHEM) for storage and made into kinase buffer solution to create a com...				US Patent US9212178 (2015) BindingDB Entry DOI: 10.7270/Q2X9294C
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM138218 (US8871778, 254) Show SMILES C[C@@H]1C[C@@H](O)CN1Cc1cn(nc1C)-c1ccnc(Nc2ccc3n(C)c(C)c(Cl)c3c2)n1 |r| Show InChI InChI=1S/C24H28ClN7O/c1-14-9-19(33)13-31(14)11-17-12-32(29-15(17)2)22-7-8-26-24(28-22)27-18-5-6-21-20(10-18)23(25)16(3)30(21)4/h5-8,10,12,14,19,33H,9,11,13H2,1-4H3,(H,26,27,28)/t14-,19-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	25
Genosco; Oscotec, Inc. US Patent					Assay Description Compounds of the invention were initially diluted to 10 mM in 100% DMSO (CALBIOCHEM) for storage and made into kinase buffer solution to create a com...				US Patent US8871778 (2014) BindingDB Entry DOI: 10.7270/Q2X065R6
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM138204 (US8871778, 161) Show SMILES Cc1nn(cc1CN1CC(O)C1)-c1ccnc(Nc2ccc3n(C)nc(Cl)c3c2)n1 Show InChI InChI=1S/C20H21ClN8O/c1-12-13(8-28-10-15(30)11-28)9-29(25-12)18-5-6-22-20(24-18)23-14-3-4-17-16(7-14)19(21)26-27(17)2/h3-7,9,15,30H,8,10-11H2,1-2H3,(H,22,23,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid PDB UniChem Similars	PDB US Patent	n/a	n/a	11.1	n/a	n/a	n/a	n/a	n/a	25
Genosco; Oscotec, Inc. US Patent					Assay Description Compounds of the invention were initially diluted to 10 mM in 100% DMSO (CALBIOCHEM) for storage and made into kinase buffer solution to create a com...				US Patent US8871778 (2014) BindingDB Entry DOI: 10.7270/Q2X065R6
					More data for this Ligand-Target Pair				3D Structure (crystal)
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM138205 (US8871778, 163) Show SMILES CC(C)n1nc(Cl)c2cc(Nc3nccc(n3)-n3cc(CN4CC(O)C4)c(C)n3)ccc12 Show InChI InChI=1S/C22H25ClN8O/c1-13(2)31-19-5-4-16(8-18(19)21(23)28-31)25-22-24-7-6-20(26-22)30-10-15(14(3)27-30)9-29-11-17(32)12-29/h4-8,10,13,17,32H,9,11-12H2,1-3H3,(H,24,25,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	12.6	n/a	n/a	n/a	n/a	n/a	25
Genosco; Oscotec, Inc. US Patent					Assay Description Compounds of the invention were initially diluted to 10 mM in 100% DMSO (CALBIOCHEM) for storage and made into kinase buffer solution to create a com...				US Patent US8871778 (2014) BindingDB Entry DOI: 10.7270/Q2X065R6
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM138214 (US8871778, 231) Show SMILES Cc1nn(cc1CN1C[C@H](O)C[C@H]1C(O)=O)-c1ccnc(Nc2ccc3n(C)c(C)c(Cl)c3c2)n1 |r| Show InChI InChI=1S/C24H26ClN7O3/c1-13-15(10-31-12-17(33)9-20(31)23(34)35)11-32(29-13)21-6-7-26-24(28-21)27-16-4-5-19-18(8-16)22(25)14(2)30(19)3/h4-8,11,17,20,33H,9-10,12H2,1-3H3,(H,34,35)(H,26,27,28)/t17-,20+/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	25
Genosco; Oscotec, Inc. US Patent					Assay Description Compounds of the invention were initially diluted to 10 mM in 100% DMSO (CALBIOCHEM) for storage and made into kinase buffer solution to create a com...				US Patent US8871778 (2014) BindingDB Entry DOI: 10.7270/Q2X065R6
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM196780 (US9212178, 9) Show SMILES CC(=O)c1cn(C)c2ccc(Nc3nccc(n3)-n3cc(CN4C[C@H](O)CO4)c(C)n3)cc12 |r| Show InChI InChI=1S/C23H25N7O3/c1-14-16(9-29-11-18(32)13-33-29)10-30(27-14)22-6-7-24-23(26-22)25-17-4-5-21-19(8-17)20(15(2)31)12-28(21)3/h4-8,10,12,18,32H,9,11,13H2,1-3H3,(H,24,25,26)/t18-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	13.3	n/a	n/a	n/a	n/a	n/a	25
Genosco; Oscotec, Inc. US Patent					Assay Description Compounds of the invention were initially diluted to 10 mM in 100% DMSO (CALBIOCHEM) for storage and made into kinase buffer solution to create a com...				US Patent US9212178 (2015) BindingDB Entry DOI: 10.7270/Q2X9294C
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM196783 (US9212178, 12) Show SMILES Cc1nn(cc1CN1C[C@H](O)CO1)-c1ccnc(Nc2ccc3[nH]cc(C(=O)C4CC4)c3c2)n1 |r| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	13.5	n/a	n/a	n/a	n/a	n/a	25
Genosco; Oscotec, Inc. US Patent					Assay Description Compounds of the invention were initially diluted to 10 mM in 100% DMSO (CALBIOCHEM) for storage and made into kinase buffer solution to create a com...				US Patent US9212178 (2015) BindingDB Entry DOI: 10.7270/Q2X9294C
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM196787 (US9212178, 16) Show SMILES Cc1nn(cc1CN1CC(C)(O)CO1)-c1ccnc(Nc2ccc3n(CC(F)(F)F)cc(C(=O)C4CC4)c3c2)n1 Show InChI InChI=1S/C27H28F3N7O3/c1-16-18(10-36-13-26(2,39)15-40-36)11-37(34-16)23-7-8-31-25(33-23)32-19-5-6-22-20(9-19)21(24(38)17-3-4-17)12-35(22)14-27(28,29)30/h5-9,11-12,17,39H,3-4,10,13-15H2,1-2H3,(H,31,32,33)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	14.2	n/a	n/a	n/a	n/a	n/a	25
Genosco; Oscotec, Inc. US Patent					Assay Description Compounds of the invention were initially diluted to 10 mM in 100% DMSO (CALBIOCHEM) for storage and made into kinase buffer solution to create a com...				US Patent US9212178 (2015) BindingDB Entry DOI: 10.7270/Q2X9294C
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM138203 (US8871778, 160) Show SMILES Cc1nn(cc1CN1CC(O)C1)-c1ccnc(Nc2ccc3n(C)ncc3c2)n1 Show InChI InChI=1S/C20H22N8O/c1-13-15(9-27-11-17(29)12-27)10-28(25-13)19-5-6-21-20(24-19)23-16-3-4-18-14(7-16)8-22-26(18)2/h3-8,10,17,29H,9,11-12H2,1-2H3,(H,21,23,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid PDB UniChem Similars	PDB US Patent	n/a	n/a	15.2	n/a	n/a	n/a	n/a	n/a	25
Genosco; Oscotec, Inc. US Patent					Assay Description Compounds of the invention were initially diluted to 10 mM in 100% DMSO (CALBIOCHEM) for storage and made into kinase buffer solution to create a com...				US Patent US8871778 (2014) BindingDB Entry DOI: 10.7270/Q2X065R6
					More data for this Ligand-Target Pair				3D Structure (crystal)
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM196784 (US9212178, 13) Show SMILES CCn1cc(C(=O)C2CC2)c2cc(Nc3nccc(n3)-n3cc(CN4CC(C)(O)CO4)c(C)n3)ccc12 Show InChI InChI=1S/C27H31N7O3/c1-4-32-14-22(25(35)18-5-6-18)21-11-20(7-8-23(21)32)29-26-28-10-9-24(30-26)34-13-19(17(2)31-34)12-33-15-27(3,36)16-37-33/h7-11,13-14,18,36H,4-6,12,15-16H2,1-3H3,(H,28,29,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	17.3	n/a	n/a	n/a	n/a	n/a	25
Genosco; Oscotec, Inc. US Patent					Assay Description Compounds of the invention were initially diluted to 10 mM in 100% DMSO (CALBIOCHEM) for storage and made into kinase buffer solution to create a com...				US Patent US9212178 (2015) BindingDB Entry DOI: 10.7270/Q2X9294C
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM138216 (US8871778, 240) Show SMILES Cc1nn(cc1CCN1CC[C@@H](O)C1)-c1ccnc(Nc2ccc3n(C)c(C)c(Cl)c3c2)n1 |r| Show InChI InChI=1S/C24H28ClN7O/c1-15-17(7-10-31-11-8-19(33)14-31)13-32(29-15)22-6-9-26-24(28-22)27-18-4-5-21-20(12-18)23(25)16(2)30(21)3/h4-6,9,12-13,19,33H,7-8,10-11,14H2,1-3H3,(H,26,27,28)/t19-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	17.5	n/a	n/a	n/a	n/a	n/a	25
Genosco; Oscotec, Inc. US Patent					Assay Description Compounds of the invention were initially diluted to 10 mM in 100% DMSO (CALBIOCHEM) for storage and made into kinase buffer solution to create a com...				US Patent US8871778 (2014) BindingDB Entry DOI: 10.7270/Q2X065R6
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM60665 (BDBM50249542 | US9145414, R406 | US9212178, R406) Show SMILES COc1cc(Nc2ncc(F)c(Nc3ccc4OC(C)(C)C(=O)Nc4n3)n2)cc(OC)c1OC Show InChI InChI=1S/C22H23FN6O5/c1-22(2)20(30)28-19-13(34-22)6-7-16(27-19)26-18-12(23)10-24-21(29-18)25-11-8-14(31-3)17(33-5)15(9-11)32-4/h6-10H,1-5H3,(H3,24,25,26,27,28,29,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE PC cid PC sid PDB UniChem Similars	DrugBank US Patent	n/a	n/a	23.6	n/a	n/a	n/a	n/a	n/a	25
Genosco; Oscotec, Inc. US Patent					Assay Description Compounds of the invention were initially diluted to 10 mM in 100% DMSO (CALBIOCHEM) for storage and made into kinase buffer solution to create a com...				US Patent US9212178 (2015) BindingDB Entry DOI: 10.7270/Q2X9294C
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM138206 (US8871778, 173) Show SMILES Cc1nn(cc1CN1CC(O)C1)-c1ccnc(Nc2ccc3oc(C)c(Cl)c3c2)n1 Show InChI InChI=1S/C21H21ClN6O2/c1-12-14(8-27-10-16(29)11-27)9-28(26-12)19-5-6-23-21(25-19)24-15-3-4-18-17(7-15)20(22)13(2)30-18/h3-7,9,16,29H,8,10-11H2,1-2H3,(H,23,24,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	24.3	n/a	n/a	n/a	n/a	n/a	25
Genosco; Oscotec, Inc. US Patent					Assay Description Compounds of the invention were initially diluted to 10 mM in 100% DMSO (CALBIOCHEM) for storage and made into kinase buffer solution to create a com...				US Patent US8871778 (2014) BindingDB Entry DOI: 10.7270/Q2X065R6
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM196781 (US9212178, 10) Show SMILES Cc1nn(cc1CN1C[C@@H](O)CO1)-c1ccnc(Nc2ccc3n(C)cc(C(=O)C(F)F)c3c2)n1 |r| Show InChI InChI=1S/C23H23F2N7O3/c1-13-14(8-31-10-16(33)12-35-31)9-32(29-13)20-5-6-26-23(28-20)27-15-3-4-19-17(7-15)18(11-30(19)2)21(34)22(24)25/h3-7,9,11,16,22,33H,8,10,12H2,1-2H3,(H,26,27,28)/t16-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	24.4	n/a	n/a	n/a	n/a	n/a	25
Genosco; Oscotec, Inc. US Patent					Assay Description Compounds of the invention were initially diluted to 10 mM in 100% DMSO (CALBIOCHEM) for storage and made into kinase buffer solution to create a com...				US Patent US9212178 (2015) BindingDB Entry DOI: 10.7270/Q2X9294C
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM196802 (US9212178, 31) Show SMILES Cc1nn(cc1CN1C[C@H](O)CO1)-c1ccnc(Nc2ccc3n(C)c(C)c(Cl)c3c2)n1 |r| Show InChI InChI=1S/C22H24ClN7O2/c1-13-15(9-29-11-17(31)12-32-29)10-30(27-13)20-6-7-24-22(26-20)25-16-4-5-19-18(8-16)21(23)14(2)28(19)3/h4-8,10,17,31H,9,11-12H2,1-3H3,(H,24,25,26)/t17-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	26.7	n/a	n/a	n/a	n/a	n/a	25
Genosco; Oscotec, Inc. US Patent					Assay Description Compounds of the invention were initially diluted to 10 mM in 100% DMSO (CALBIOCHEM) for storage and made into kinase buffer solution to create a com...				US Patent US9212178 (2015) BindingDB Entry DOI: 10.7270/Q2X9294C
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM196785 (US9212178, 14) Show SMILES Cc1nn(cc1CN1CC(C)(O)CO1)-c1ccnc(Nc2ccc3n(C)cc(C(=O)C4CC4)c3c2)n1 Show InChI InChI=1S/C26H29N7O3/c1-16-18(11-32-14-26(2,35)15-36-32)12-33(30-16)23-8-9-27-25(29-23)28-19-6-7-22-20(10-19)21(13-31(22)3)24(34)17-4-5-17/h6-10,12-13,17,35H,4-5,11,14-15H2,1-3H3,(H,27,28,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	41.7	n/a	n/a	n/a	n/a	n/a	25
Genosco; Oscotec, Inc. US Patent					Assay Description Compounds of the invention were initially diluted to 10 mM in 100% DMSO (CALBIOCHEM) for storage and made into kinase buffer solution to create a com...				US Patent US9212178 (2015) BindingDB Entry DOI: 10.7270/Q2X9294C
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM196776 (US9212178, 5) Show SMILES CCOC(=O)n1cc(C(C)=O)c2cc(Nc3nccc(n3)-n3cc(CN4C[C@H](O)CO4)c(C)n3)ccc12 |r| Show InChI InChI=1S/C25H27N7O5/c1-4-36-25(35)31-13-21(16(3)33)20-9-18(5-6-22(20)31)27-24-26-8-7-23(28-24)32-11-17(15(2)29-32)10-30-12-19(34)14-37-30/h5-9,11,13,19,34H,4,10,12,14H2,1-3H3,(H,26,27,28)/t19-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	45.6	n/a	n/a	n/a	n/a	n/a	25
Genosco; Oscotec, Inc. US Patent					Assay Description Compounds of the invention were initially diluted to 10 mM in 100% DMSO (CALBIOCHEM) for storage and made into kinase buffer solution to create a com...				US Patent US9212178 (2015) BindingDB Entry DOI: 10.7270/Q2X9294C
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM196791 (US9212178, 20 | US9212178, 21) Show SMILES CCn1cc(C(=O)C2CC2)c2cc(Nc3ncc(F)c(n3)-n3cc(CN4C[C@H](O)CO4)c(C)n3)ccc12 |r| Show InChI InChI=1S/C26H28FN7O3/c1-3-32-13-21(24(36)16-4-5-16)20-8-18(6-7-23(20)32)29-26-28-9-22(27)25(30-26)34-11-17(15(2)31-34)10-33-12-19(35)14-37-33/h6-9,11,13,16,19,35H,3-5,10,12,14H2,1-2H3,(H,28,29,30)/t19-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	66.2	n/a	n/a	n/a	n/a	n/a	25
Genosco; Oscotec, Inc. US Patent					Assay Description Compounds of the invention were initially diluted to 10 mM in 100% DMSO (CALBIOCHEM) for storage and made into kinase buffer solution to create a com...				US Patent US9212178 (2015) BindingDB Entry DOI: 10.7270/Q2X9294C
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM196777 (US9212178, 29 | US9212178, 6) Show SMILES CCn1cc(C(=O)C2CC2)c2cc(Nc3nccc(n3)-n3cc(CN4C[C@H](O)CO4)c(C)n3)ccc12 |r| Show InChI InChI=1S/C26H29N7O3/c1-3-31-14-22(25(35)17-4-5-17)21-10-19(6-7-23(21)31)28-26-27-9-8-24(29-26)33-12-18(16(2)30-33)11-32-13-20(34)15-36-32/h6-10,12,14,17,20,34H,3-5,11,13,15H2,1-2H3,(H,27,28,29)/t20-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	69.5	n/a	n/a	n/a	n/a	n/a	25
Genosco; Oscotec, Inc. US Patent					Assay Description Compounds of the invention were initially diluted to 10 mM in 100% DMSO (CALBIOCHEM) for storage and made into kinase buffer solution to create a com...				US Patent US9212178 (2015) BindingDB Entry DOI: 10.7270/Q2X9294C
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM196793 (US9212178, 22) Show SMILES CCn1cc(C(=O)C2CC2)c2cc(Nc3ncc(C)c(n3)-n3cc(CN4C[C@H](O)CO4)c(C)n3)ccc12 |r| Show InChI InChI=1S/C27H31N7O3/c1-4-32-14-23(25(36)18-5-6-18)22-9-20(7-8-24(22)32)29-27-28-10-16(2)26(30-27)34-12-19(17(3)31-34)11-33-13-21(35)15-37-33/h7-10,12,14,18,21,35H,4-6,11,13,15H2,1-3H3,(H,28,29,30)/t21-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	79.3	n/a	n/a	n/a	n/a	n/a	25
Genosco; Oscotec, Inc. US Patent					Assay Description Compounds of the invention were initially diluted to 10 mM in 100% DMSO (CALBIOCHEM) for storage and made into kinase buffer solution to create a com...				US Patent US9212178 (2015) BindingDB Entry DOI: 10.7270/Q2X9294C
					More data for this Ligand-Target Pair

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