Found 20 hits with Last Name = 'bielska' and Initial = 'm' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50205604
(CHEMBL3907401)Show SMILES COc1ccc(cc1OC)C1=NN(Cc2ccc(F)cc2)C(=O)CCC1 |t:11| Show InChI InChI=1S/C20H21FN2O3/c1-25-18-11-8-15(12-19(18)26-2)17-4-3-5-20(24)23(22-17)13-14-6-9-16(21)10-7-14/h6-12H,3-5,13H2,1-2H3 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 170 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Genoa
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PDE4B2 using cAMP as substrate after 2 hrs by TR-FRET assay |
Bioorg Med Chem Lett 27: 24-29 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.040 BindingDB Entry DOI: 10.7270/Q21N8333 |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50205613
(CHEMBL3934464)Show InChI InChI=1S/C16H22N2O3/c1-4-10-18-16(19)7-5-6-13(17-18)12-8-9-14(20-2)15(11-12)21-3/h8-9,11H,4-7,10H2,1-3H3 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 260 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Genoa
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PDE4B2 using cAMP as substrate after 2 hrs by TR-FRET assay |
Bioorg Med Chem Lett 27: 24-29 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.040 BindingDB Entry DOI: 10.7270/Q21N8333 |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50205599
(CHEMBL3933197)Show SMILES COc1ccc(cc1OC)C1=NN(Cc2cccnc2)C(=O)CCC1 |t:11| Show InChI InChI=1S/C19H21N3O3/c1-24-17-9-8-15(11-18(17)25-2)16-6-3-7-19(23)22(21-16)13-14-5-4-10-20-12-14/h4-5,8-12H,3,6-7,13H2,1-2H3 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 290 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Genoa
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PDE4B2 using cAMP as substrate after 2 hrs by TR-FRET assay |
Bioorg Med Chem Lett 27: 24-29 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.040 BindingDB Entry DOI: 10.7270/Q21N8333 |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50205619
(CHEMBL3965269)Show SMILES COc1ccc(cc1OC)C1=NN(CC2CCC2)C(=O)CCC1 |t:11| Show InChI InChI=1S/C18H24N2O3/c1-22-16-10-9-14(11-17(16)23-2)15-7-4-8-18(21)20(19-15)12-13-5-3-6-13/h9-11,13H,3-8,12H2,1-2H3 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 320 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Genoa
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PDE4B2 using cAMP as substrate after 2 hrs by TR-FRET assay |
Bioorg Med Chem Lett 27: 24-29 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.040 BindingDB Entry DOI: 10.7270/Q21N8333 |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50205603
(CHEMBL3937306)Show SMILES COc1ccc(cc1OC)C1=NN(CC(C)C)C(=O)CCC1 |t:11| Show InChI InChI=1S/C17H24N2O3/c1-12(2)11-19-17(20)7-5-6-14(18-19)13-8-9-15(21-3)16(10-13)22-4/h8-10,12H,5-7,11H2,1-4H3 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 340 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Genoa
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PDE4B2 using cAMP as substrate after 2 hrs by TR-FRET assay |
Bioorg Med Chem Lett 27: 24-29 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.040 BindingDB Entry DOI: 10.7270/Q21N8333 |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50205600
(CHEMBL3897315)Show InChI InChI=1S/C16H20N2O3/c1-4-10-18-16(19)7-5-6-13(17-18)12-8-9-14(20-2)15(11-12)21-3/h4,8-9,11H,1,5-7,10H2,2-3H3 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.13E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Genoa
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PDE4B2 using cAMP as substrate after 2 hrs by TR-FRET assay |
Bioorg Med Chem Lett 27: 24-29 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.040 BindingDB Entry DOI: 10.7270/Q21N8333 |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50205614
(CHEMBL3892849)Show SMILES CCN(CC)CCN1N=C(CCCC1=O)c1ccc(OC)c(OC)c1 |c:8| Show InChI InChI=1S/C19H29N3O3/c1-5-21(6-2)12-13-22-19(23)9-7-8-16(20-22)15-10-11-17(24-3)18(14-15)25-4/h10-11,14H,5-9,12-13H2,1-4H3 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.22E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Genoa
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PDE4B2 using cAMP as substrate after 2 hrs by TR-FRET assay |
Bioorg Med Chem Lett 27: 24-29 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.040 BindingDB Entry DOI: 10.7270/Q21N8333 |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50205610
(CHEMBL3926566)Show InChI InChI=1S/C16H22N2O4/c1-21-14-8-7-12(11-15(14)22-2)13-5-3-6-16(20)18(17-13)9-4-10-19/h7-8,11,19H,3-6,9-10H2,1-2H3 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.22E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Genoa
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PDE4B2 using cAMP as substrate after 2 hrs by TR-FRET assay |
Bioorg Med Chem Lett 27: 24-29 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.040 BindingDB Entry DOI: 10.7270/Q21N8333 |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50205602
(CHEMBL3919202)Show SMILES COc1ccc(cc1OC)C1=NN(Cc2ccc(F)cc2)C(=O)CC(C)(C)C1 |t:11| Show InChI InChI=1S/C22H25FN2O3/c1-22(2)12-18(16-7-10-19(27-3)20(11-16)28-4)24-25(21(26)13-22)14-15-5-8-17(23)9-6-15/h5-11H,12-14H2,1-4H3 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.22E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Genoa
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PDE4B2 using cAMP as substrate after 2 hrs by TR-FRET assay |
Bioorg Med Chem Lett 27: 24-29 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.040 BindingDB Entry DOI: 10.7270/Q21N8333 |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50205611
(CHEMBL3969575)Show SMILES COc1ccc(cc1OC)C1=NN(Cc2ccc(cc2)S(C)(=O)=O)C(=O)CCC1 |t:11| Show InChI InChI=1S/C21H24N2O5S/c1-27-19-12-9-16(13-20(19)28-2)18-5-4-6-21(24)23(22-18)14-15-7-10-17(11-8-15)29(3,25)26/h7-13H,4-6,14H2,1-3H3 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.29E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Genoa
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PDE4B2 using cAMP as substrate after 2 hrs by TR-FRET assay |
Bioorg Med Chem Lett 27: 24-29 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.040 BindingDB Entry DOI: 10.7270/Q21N8333 |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50205608
(CHEMBL3898376)Show SMILES COc1ccc(cc1OC)C1=NN(Cc2ccncc2)C(=O)CCC1 |t:11| Show InChI InChI=1S/C19H21N3O3/c1-24-17-7-6-15(12-18(17)25-2)16-4-3-5-19(23)22(21-16)13-14-8-10-20-11-9-14/h6-12H,3-5,13H2,1-2H3 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.41E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Genoa
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PDE4B2 using cAMP as substrate after 2 hrs by TR-FRET assay |
Bioorg Med Chem Lett 27: 24-29 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.040 BindingDB Entry DOI: 10.7270/Q21N8333 |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM14769
(6-(3,4-Dimethoxy-phenyl)-4,5-dimethyl-4,5-dihydro-...)Show InChI InChI=1S/C12H10F2N2O3/c1-18-10-6-7(2-4-9(10)19-12(13)14)8-3-5-11(17)16-15-8/h2-6,12H,1H3,(H,16,17) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 1.41E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Genoa
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PDE4B2 using cAMP as substrate after 2 hrs by TR-FRET assay |
Bioorg Med Chem Lett 27: 24-29 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.040 BindingDB Entry DOI: 10.7270/Q21N8333 |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50205617
(CHEMBL3916376)Show InChI InChI=1S/C17H24N2O4/c1-4-23-11-10-19-17(20)7-5-6-14(18-19)13-8-9-15(21-2)16(12-13)22-3/h8-9,12H,4-7,10-11H2,1-3H3 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 2.27E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Genoa
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PDE4B2 using cAMP as substrate after 2 hrs by TR-FRET assay |
Bioorg Med Chem Lett 27: 24-29 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.040 BindingDB Entry DOI: 10.7270/Q21N8333 |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50205609
(CHEMBL3938207)Show SMILES COc1ccc(cc1OC)C1=NN(CCCO)C(=O)CC(C)(C)C1 |t:11| Show InChI InChI=1S/C18H26N2O4/c1-18(2)11-14(19-20(8-5-9-21)17(22)12-18)13-6-7-15(23-3)16(10-13)24-4/h6-7,10,21H,5,8-9,11-12H2,1-4H3 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.69E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Genoa
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PDE4B2 using cAMP as substrate after 2 hrs by TR-FRET assay |
Bioorg Med Chem Lett 27: 24-29 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.040 BindingDB Entry DOI: 10.7270/Q21N8333 |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50205605
(CHEMBL3932749)Show InChI InChI=1S/C15H20N2O3/c1-15(2)8-11(16-17-14(18)9-15)10-5-6-12(19-3)13(7-10)20-4/h5-7H,8-9H2,1-4H3,(H,17,18) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3.53E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Genoa
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PDE4B2 using cAMP as substrate after 2 hrs by TR-FRET assay |
Bioorg Med Chem Lett 27: 24-29 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.040 BindingDB Entry DOI: 10.7270/Q21N8333 |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50205618
(CHEMBL3929714)Show InChI InChI=1S/C12H14O4/c1-16-10-7-5-9(6-8-10)11(13)3-2-4-12(14)15/h5-8H,2-4H2,1H3,(H,14,15) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3.53E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Genoa
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PDE4B2 using cAMP as substrate after 2 hrs by TR-FRET assay |
Bioorg Med Chem Lett 27: 24-29 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.040 BindingDB Entry DOI: 10.7270/Q21N8333 |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50205601
(CHEMBL3892468)Show InChI InChI=1S/C13H16N2O3/c1-17-11-7-6-9(8-12(11)18-2)10-4-3-5-13(16)15-14-10/h6-8H,3-5H2,1-2H3,(H,15,16) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4.17E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Genoa
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PDE4B2 using cAMP as substrate after 2 hrs by TR-FRET assay |
Bioorg Med Chem Lett 27: 24-29 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.040 BindingDB Entry DOI: 10.7270/Q21N8333 |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50205607
(CHEMBL3925358)Show SMILES COc1ccc(cc1OC)C1=NN(CC(N)=O)C(=O)CCC1 |t:11| Show InChI InChI=1S/C15H19N3O4/c1-21-12-7-6-10(8-13(12)22-2)11-4-3-5-15(20)18(17-11)9-14(16)19/h6-8H,3-5,9H2,1-2H3,(H2,16,19) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 7.55E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Genoa
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PDE4B2 using cAMP as substrate after 2 hrs by TR-FRET assay |
Bioorg Med Chem Lett 27: 24-29 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.040 BindingDB Entry DOI: 10.7270/Q21N8333 |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50205612
(CHEMBL3910284)Show SMILES COc1ccc(cc1OC)C1=NN(CC(O)=O)C(=O)CC(C)(C)C1 |t:11| Show InChI InChI=1S/C17H22N2O5/c1-17(2)8-12(18-19(10-16(21)22)15(20)9-17)11-5-6-13(23-3)14(7-11)24-4/h5-7H,8-10H2,1-4H3,(H,21,22) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.31E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Genoa
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PDE4B2 using cAMP as substrate after 2 hrs by TR-FRET assay |
Bioorg Med Chem Lett 27: 24-29 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.040 BindingDB Entry DOI: 10.7270/Q21N8333 |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50205606
(CHEMBL3945980)Show InChI InChI=1S/C12H14N2O2/c1-16-10-7-5-9(6-8-10)11-3-2-4-12(15)14-13-11/h5-8H,2-4H2,1H3,(H,14,15) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Genoa
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PDE4B2 using cAMP as substrate after 2 hrs by TR-FRET assay |
Bioorg Med Chem Lett 27: 24-29 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.040 BindingDB Entry DOI: 10.7270/Q21N8333 |
More data for this Ligand-Target Pair | |