Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Receptor-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human)) | BDBM50159507![]() (CHEMBL3785703) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars | PDB Article PubMed | 0.800 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Competitive inhibition of human RIP1 (1 to 375 residues) in presence of increasing ATP by ADP-Glo reagent based assay | J Med Chem 59: 2163-78 (2016) Article DOI: 10.1021/acs.jmedchem.5b01898 BindingDB Entry DOI: 10.7270/Q26H4K97 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Integrin alpha-V/beta-5 (Homo sapiens (Human)) | BDBM50078714![]() (CHEMBL288493 | SB-265123 | {(S)-3-[3-(Pyridin-2-yl...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 1.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals Curated by ChEMBL | Assay Description Binding affinity for non-peptide Vitronectin receptor (alpha V beta 3) | Bioorg Med Chem Lett 9: 1807-12 (1999) BindingDB Entry DOI: 10.7270/Q2Q23ZFC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-V/beta-3 (Homo sapiens (Human)) | BDBM50059133![]() (CHEMBL50106 | SB-223245 | {(S)-7-[(1H-Benzoimidazo...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 2 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals Curated by ChEMBL | Assay Description Inhibition of HEK 293 cell adhesion to vitronectin by alpha V beta 3 | Bioorg Med Chem Lett 9: 1807-12 (1999) BindingDB Entry DOI: 10.7270/Q2Q23ZFC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-V/beta-3 (Homo sapiens (Human)) | BDBM50078714![]() (CHEMBL288493 | SB-265123 | {(S)-3-[3-(Pyridin-2-yl...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals Curated by ChEMBL | Assay Description Inhibition of HEK 293 cell adhesion to vitronectin by alpha V beta 3 | Bioorg Med Chem Lett 9: 1807-12 (1999) BindingDB Entry DOI: 10.7270/Q2Q23ZFC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-V/beta-3 (Homo sapiens (Human)) | BDBM50078713![]() (CHEMBL416493 | {3-[3-(Pyridin-2-ylamino)-propoxy]-...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 8 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals Curated by ChEMBL | Assay Description Binding affinity for non-peptide Vitronectin receptor (alpha V beta 3) | Bioorg Med Chem Lett 9: 1807-12 (1999) BindingDB Entry DOI: 10.7270/Q2Q23ZFC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-V/beta-3 (Homo sapiens (Human)) | BDBM50078715![]() (CHEMBL299402 | {3-[(1H-Benzoimidazol-2-ylmethyl)-m...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Patents | PubMed | 23 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals Curated by ChEMBL | Assay Description Inhibition of HEK 293 cell adhesion to vitronectin by alpha V beta 3 | Bioorg Med Chem Lett 9: 1807-12 (1999) BindingDB Entry DOI: 10.7270/Q2Q23ZFC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-V/beta-3 (Homo sapiens (Human)) | BDBM50078716![]() (CHEMBL52464 | {(R)-3-[3-(Pyridin-2-ylamino)-propox...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 550 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals Curated by ChEMBL | Assay Description Binding affinity for alpha IIb beta3 integrin | Bioorg Med Chem Lett 9: 1807-12 (1999) BindingDB Entry DOI: 10.7270/Q2Q23ZFC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-IIb/beta-3 (Homo sapiens (Human)) | BDBM50078714![]() (CHEMBL288493 | SB-265123 | {(S)-3-[3-(Pyridin-2-yl...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 9.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals Curated by ChEMBL | Assay Description Binding affinity for non-peptide Vitronectin receptor (alpha V beta 3) | Bioorg Med Chem Lett 9: 1807-12 (1999) BindingDB Entry DOI: 10.7270/Q2Q23ZFC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-V/beta-1 (Homo sapiens (Human)) | BDBM50078714![]() (CHEMBL288493 | SB-265123 | {(S)-3-[3-(Pyridin-2-yl...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 1.80E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals Curated by ChEMBL | Assay Description Binding affinity for integrin alpha V beta 5 receptor | Bioorg Med Chem Lett 9: 1807-12 (1999) BindingDB Entry DOI: 10.7270/Q2Q23ZFC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-IIb/beta-3 (Homo sapiens (Human)) | BDBM50059133![]() (CHEMBL50106 | SB-223245 | {(S)-7-[(1H-Benzoimidazo...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals Curated by ChEMBL | Assay Description Binding affinity for alpha V beta 1 receptor | Bioorg Med Chem Lett 9: 1807-12 (1999) BindingDB Entry DOI: 10.7270/Q2Q23ZFC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-IIb/beta-3 (Homo sapiens (Human)) | BDBM50078713![]() (CHEMBL416493 | {3-[3-(Pyridin-2-ylamino)-propoxy]-...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals Curated by ChEMBL | Assay Description Binding affinity for alpha IIb beta3 integrin | Bioorg Med Chem Lett 9: 1807-12 (1999) BindingDB Entry DOI: 10.7270/Q2Q23ZFC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-IIb/beta-3 (Homo sapiens (Human)) | BDBM50078715![]() (CHEMBL299402 | {3-[(1H-Benzoimidazol-2-ylmethyl)-m...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Patents | PubMed | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals Curated by ChEMBL | Assay Description Binding affinity for non-peptide Vitronectin receptor (alpha V beta 3) | Bioorg Med Chem Lett 9: 1807-12 (1999) BindingDB Entry DOI: 10.7270/Q2Q23ZFC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Receptor-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human)) | BDBM50233227![]() (CHEMBL4067372) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 0.0500 | n/a | n/a | n/a | n/a | n/a | n/a |
Queen Mary University of London Curated by ChEMBL | Assay Description Inhibition of human RIP1 (1 to 375 residues) expressed in baculovirus infected insect cells preincubated for 1 hr followed by ATP addition measured a... | J Med Chem 60: 1247-1261 (2017) Article DOI: 10.1021/acs.jmedchem.6b01751 BindingDB Entry DOI: 10.7270/Q2SQ92NR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Receptor-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human)) | BDBM50159697![]() (CHEMBL3785745) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.0630 | n/a | n/a | n/a | n/a | n/a | n/a |
Queen Mary University of London Curated by ChEMBL | Assay Description Inhibition of human RIP1 (1 to 375 residues) expressed in baculovirus infected insect cells preincubated for 1 hr followed by ATP addition measured a... | J Med Chem 60: 1247-1261 (2017) Article DOI: 10.1021/acs.jmedchem.6b01751 BindingDB Entry DOI: 10.7270/Q2SQ92NR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Receptor-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human)) | BDBM50233256![]() (CHEMBL4093220) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.0790 | n/a | n/a | n/a | n/a | n/a | n/a |
Queen Mary University of London Curated by ChEMBL | Assay Description Inhibition of human RIP1 (1 to 375 residues) expressed in baculovirus infected insect cells preincubated for 1 hr followed by ATP addition measured a... | J Med Chem 60: 1247-1261 (2017) Article DOI: 10.1021/acs.jmedchem.6b01751 BindingDB Entry DOI: 10.7270/Q2SQ92NR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Receptor-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human)) | BDBM50159696![]() (CHEMBL3786997) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Inhibition of Flag-tagged human RIP1 (1 to 324 residues) after 30 mins by ADP-Glo reagent based assay | J Med Chem 59: 2163-78 (2016) Article DOI: 10.1021/acs.jmedchem.5b01898 BindingDB Entry DOI: 10.7270/Q26H4K97 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Receptor-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human)) | BDBM50159696![]() (CHEMBL3786997) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a |
Queen Mary University of London Curated by ChEMBL | Assay Description Inhibition of human RIP1 (1 to 375 residues) expressed in baculovirus infected insect cells preincubated for 1 hr followed by ATP addition measured a... | J Med Chem 60: 1247-1261 (2017) Article DOI: 10.1021/acs.jmedchem.6b01751 BindingDB Entry DOI: 10.7270/Q2SQ92NR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Receptor-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human)) | BDBM50233244![]() (CHEMBL4068954) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 0.320 | n/a | n/a | n/a | n/a | n/a | n/a |
Queen Mary University of London Curated by ChEMBL | Assay Description Inhibition of human RIP1 (1 to 375 residues) expressed in baculovirus infected insect cells preincubated for 1 hr followed by ATP addition measured a... | J Med Chem 60: 1247-1261 (2017) Article DOI: 10.1021/acs.jmedchem.6b01751 BindingDB Entry DOI: 10.7270/Q2SQ92NR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Receptor-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human)) | BDBM50233248![]() (CHEMBL4096224) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 0.320 | n/a | n/a | n/a | n/a | n/a | n/a |
Queen Mary University of London Curated by ChEMBL | Assay Description Inhibition of human RIP1 (1 to 375 residues) expressed in baculovirus infected insect cells preincubated for 1 hr followed by ATP addition measured a... | J Med Chem 60: 1247-1261 (2017) Article DOI: 10.1021/acs.jmedchem.6b01751 BindingDB Entry DOI: 10.7270/Q2SQ92NR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Receptor-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human)) | BDBM50233228![]() (CHEMBL4060644) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Patents | Article PubMed | n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a |
Queen Mary University of London Curated by ChEMBL | Assay Description Inhibition of human RIP1 (1 to 375 residues) expressed in baculovirus infected insect cells preincubated for 1 hr followed by ATP addition measured a... | J Med Chem 60: 1247-1261 (2017) Article DOI: 10.1021/acs.jmedchem.6b01751 BindingDB Entry DOI: 10.7270/Q2SQ92NR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Receptor-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human)) | BDBM50233225![]() (CHEMBL4071864) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a |
Queen Mary University of London Curated by ChEMBL | Assay Description Inhibition of RIP1 in human primary neutrophils assessed as reduction in TNFalpha/QCD-OPh/SMAC mimetic RMT 5265-induced necroptosis at 21 hrs post-st... | J Med Chem 60: 1247-1261 (2017) Article DOI: 10.1021/acs.jmedchem.6b01751 BindingDB Entry DOI: 10.7270/Q2SQ92NR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Receptor-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human)) | BDBM50233255![]() (CHEMBL4069318) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a |
Queen Mary University of London Curated by ChEMBL | Assay Description Inhibition of human RIP1 (1 to 375 residues) expressed in baculovirus infected insect cells preincubated for 1 hr followed by ATP addition measured a... | J Med Chem 60: 1247-1261 (2017) Article DOI: 10.1021/acs.jmedchem.6b01751 BindingDB Entry DOI: 10.7270/Q2SQ92NR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Receptor-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human)) | BDBM50159693![]() (CHEMBL3785482) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Inhibition of Flag-tagged human RIP1 (1 to 324 residues) after 30 mins by ADP-Glo reagent based assay | J Med Chem 59: 2163-78 (2016) Article DOI: 10.1021/acs.jmedchem.5b01898 BindingDB Entry DOI: 10.7270/Q26H4K97 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Receptor-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human)) | BDBM50233225![]() (CHEMBL4071864) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Queen Mary University of London Curated by ChEMBL | Assay Description Inhibition of RIP1 in human primary neutrophils assessed as reduction in TNFalpha/QCD-OPh/SMAC mimetic RMT 5265-MIP-1beta production at 21 hrs post-s... | J Med Chem 60: 1247-1261 (2017) Article DOI: 10.1021/acs.jmedchem.6b01751 BindingDB Entry DOI: 10.7270/Q2SQ92NR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Receptor-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human)) | BDBM50513015![]() (CHEMBL4537171) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Inhibition of human GST/His-tagged RIP1 (1 to 375 residues) expressed in baculovirus expression system assessed as reduction in autophosphorylation m... | J Med Chem 62: 5096-5110 (2019) Article DOI: 10.1021/acs.jmedchem.9b00318 BindingDB Entry DOI: 10.7270/Q24J0JFT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Receptor-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human)) | BDBM50233230![]() (CHEMBL4099004) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Queen Mary University of London Curated by ChEMBL | Assay Description Inhibition of human RIP1 (1 to 375 residues) expressed in baculovirus infected insect cells preincubated for 1 hr followed by ATP addition measured a... | J Med Chem 60: 1247-1261 (2017) Article DOI: 10.1021/acs.jmedchem.6b01751 BindingDB Entry DOI: 10.7270/Q2SQ92NR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Receptor-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human)) | BDBM50233226![]() (CHEMBL4089558) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Queen Mary University of London Curated by ChEMBL | Assay Description Inhibition of human RIP1 (1 to 375 residues) expressed in baculovirus infected insect cells preincubated for 1 hr followed by ATP addition measured a... | J Med Chem 60: 1247-1261 (2017) Article DOI: 10.1021/acs.jmedchem.6b01751 BindingDB Entry DOI: 10.7270/Q2SQ92NR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Receptor-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human)) | BDBM50233249![]() (CHEMBL4081685) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 0.630 | n/a | n/a | n/a | n/a | n/a | n/a |
Queen Mary University of London Curated by ChEMBL | Assay Description Inhibition of human RIP1 (1 to 375 residues) expressed in baculovirus infected insect cells preincubated for 1 hr followed by ATP addition measured a... | J Med Chem 60: 1247-1261 (2017) Article DOI: 10.1021/acs.jmedchem.6b01751 BindingDB Entry DOI: 10.7270/Q2SQ92NR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Receptor-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human)) | BDBM50233240![]() (CHEMBL4065561) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Patents | Article PubMed | n/a | n/a | 0.630 | n/a | n/a | n/a | n/a | n/a | n/a |
Queen Mary University of London Curated by ChEMBL | Assay Description Inhibition of human RIP1 (1 to 375 residues) expressed in baculovirus infected insect cells preincubated for 1 hr followed by ATP addition measured a... | J Med Chem 60: 1247-1261 (2017) Article DOI: 10.1021/acs.jmedchem.6b01751 BindingDB Entry DOI: 10.7270/Q2SQ92NR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Receptor-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human)) | BDBM50159508![]() (CHEMBL3786078) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 0.790 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Binding affinity to human RIP1 (1 to 375 residues) preincubated for 10 mins measured after 20 mins by fluorescence polarization assay | J Med Chem 59: 2163-78 (2016) Article DOI: 10.1021/acs.jmedchem.5b01898 BindingDB Entry DOI: 10.7270/Q26H4K97 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Receptor-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human)) | BDBM50159508![]() (CHEMBL3786078) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 0.790 | n/a | n/a | n/a | n/a | n/a | n/a |
Queen Mary University of London Curated by ChEMBL | Assay Description Inhibition of human RIP1 (1 to 375 residues) expressed in baculovirus infected insect cells preincubated for 1 hr followed by ATP addition measured a... | J Med Chem 60: 1247-1261 (2017) Article DOI: 10.1021/acs.jmedchem.6b01751 BindingDB Entry DOI: 10.7270/Q2SQ92NR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Receptor-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human)) | BDBM50233229![]() (CHEMBL4088857) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Patents | Article PubMed | n/a | n/a | 0.790 | n/a | n/a | n/a | n/a | n/a | n/a |
Queen Mary University of London Curated by ChEMBL | Assay Description Inhibition of human RIP1 (1 to 375 residues) expressed in baculovirus infected insect cells preincubated for 1 hr followed by ATP addition measured a... | J Med Chem 60: 1247-1261 (2017) Article DOI: 10.1021/acs.jmedchem.6b01751 BindingDB Entry DOI: 10.7270/Q2SQ92NR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Receptor-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human)) | BDBM50159697![]() (CHEMBL3785745) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.940 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Binding affinity to human RIP1 (1 to 375 residues) preincubated for 10 mins measured after 20 mins by fluorescence polarization assay | J Med Chem 59: 2163-78 (2016) Article DOI: 10.1021/acs.jmedchem.5b01898 BindingDB Entry DOI: 10.7270/Q26H4K97 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Receptor-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human)) | BDBM50507336![]() (CHEMBL4514271) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Inhibition of human GST/His-tagged RIP1 (1 to 375 residues) expressed in baculovirus expression system assessed as reduction in autophosphorylation m... | J Med Chem 62: 5096-5110 (2019) Article DOI: 10.1021/acs.jmedchem.9b00318 BindingDB Entry DOI: 10.7270/Q24J0JFT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Receptor-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human)) | BDBM50233252![]() (CHEMBL4080978) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Queen Mary University of London Curated by ChEMBL | Assay Description Inhibition of human RIP1 (1 to 375 residues) expressed in baculovirus infected insect cells preincubated for 1 hr followed by ATP addition measured a... | J Med Chem 60: 1247-1261 (2017) Article DOI: 10.1021/acs.jmedchem.6b01751 BindingDB Entry DOI: 10.7270/Q2SQ92NR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Receptor-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human)) | BDBM50233250![]() (CHEMBL4099698) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Queen Mary University of London Curated by ChEMBL | Assay Description Inhibition of human RIP1 (1 to 375 residues) expressed in baculovirus infected insect cells preincubated for 1 hr followed by ATP addition measured a... | J Med Chem 60: 1247-1261 (2017) Article DOI: 10.1021/acs.jmedchem.6b01751 BindingDB Entry DOI: 10.7270/Q2SQ92NR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Receptor-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human)) | BDBM50233227![]() (CHEMBL4067372) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Queen Mary University of London Curated by ChEMBL | Assay Description Inhibition of RIP1 in human U937 cells assessed as reduction in TNFalpha/QVD-Oph-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell via... | J Med Chem 60: 1247-1261 (2017) Article DOI: 10.1021/acs.jmedchem.6b01751 BindingDB Entry DOI: 10.7270/Q2SQ92NR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Receptor-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human)) | BDBM50233225![]() (CHEMBL4071864) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Queen Mary University of London Curated by ChEMBL | Assay Description Inhibition of human RIP1 (1 to 375 residues) expressed in baculovirus infected insect cells preincubated for 1 hr followed by ATP addition measured a... | J Med Chem 60: 1247-1261 (2017) Article DOI: 10.1021/acs.jmedchem.6b01751 BindingDB Entry DOI: 10.7270/Q2SQ92NR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Receptor-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human)) | BDBM50446266![]() (CHEMBL3109212) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.30 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Displacement of (14-(2-{[3-({2-{[4-(cyanomethyl)phenyl]amino}-6-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]-4-pyrimidinyl}amino)propyl]amino}-2-oxoethyl)-... | ACS Med Chem Lett 4: 1238-43 (2013) Article DOI: 10.1021/ml400382p BindingDB Entry DOI: 10.7270/Q2C24XW2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Receptor-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human)) | BDBM50513040![]() (CHEMBL4593226) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.30 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Inhibition of human GST/His-tagged RIP1 (1 to 375 residues) expressed in baculovirus expression system assessed as reduction in autophosphorylation m... | J Med Chem 62: 5096-5110 (2019) Article DOI: 10.1021/acs.jmedchem.9b00318 BindingDB Entry DOI: 10.7270/Q24J0JFT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Receptor-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human)) | BDBM50233225![]() (CHEMBL4071864) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 1.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Queen Mary University of London Curated by ChEMBL | Assay Description Inhibition of RIP1 in human primary neutrophils assessed as reduction in TNFalpha/QCD-OPh/SMAC mimetic RMT 5265-induced necroptosis by measuring cell... | J Med Chem 60: 1247-1261 (2017) Article DOI: 10.1021/acs.jmedchem.6b01751 BindingDB Entry DOI: 10.7270/Q2SQ92NR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Receptor-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human)) | BDBM50513004![]() (CHEMBL4521353) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.60 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Inhibition of human GST/His-tagged RIP1 (1 to 375 residues) expressed in baculovirus expression system assessed as reduction in autophosphorylation m... | J Med Chem 62: 5096-5110 (2019) Article DOI: 10.1021/acs.jmedchem.9b00318 BindingDB Entry DOI: 10.7270/Q24J0JFT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Receptor-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human)) | BDBM50233240![]() (CHEMBL4065561) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Patents | Article PubMed | n/a | n/a | 1.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Queen Mary University of London Curated by ChEMBL | Assay Description Inhibition of RIP1 in human U937 cells assessed as reduction in TNFalpha/QVD-Oph-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell via... | J Med Chem 60: 1247-1261 (2017) Article DOI: 10.1021/acs.jmedchem.6b01751 BindingDB Entry DOI: 10.7270/Q2SQ92NR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Receptor-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human)) | BDBM50159507![]() (CHEMBL3785703) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 1.60 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Inhibition of human RIP1 (1 to 375 residues) after 4 hrs by ADP-Glo reagent based assay | J Med Chem 59: 2163-78 (2016) Article DOI: 10.1021/acs.jmedchem.5b01898 BindingDB Entry DOI: 10.7270/Q26H4K97 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Receptor-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human)) | BDBM50513011![]() (CHEMBL4455042) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.60 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Inhibition of human GST/His-tagged RIP1 (1 to 375 residues) expressed in baculovirus expression system assessed as reduction in autophosphorylation m... | J Med Chem 62: 5096-5110 (2019) Article DOI: 10.1021/acs.jmedchem.9b00318 BindingDB Entry DOI: 10.7270/Q24J0JFT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Receptor-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human)) | BDBM50513024![]() (CHEMBL4471642) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.60 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Inhibition of human GST/His-tagged RIP1 (1 to 375 residues) expressed in baculovirus expression system assessed as reduction in autophosphorylation m... | J Med Chem 62: 5096-5110 (2019) Article DOI: 10.1021/acs.jmedchem.9b00318 BindingDB Entry DOI: 10.7270/Q24J0JFT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Receptor-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human)) | BDBM50513034![]() (CHEMBL4541955) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Inhibition of RIP1 in human U937 cells assessed as reduction in TNFalpha/QVD-Oph-induced necroptosis measured after 24 hrs by cell titer-glo luminesc... | J Med Chem 62: 5096-5110 (2019) Article DOI: 10.1021/acs.jmedchem.9b00318 BindingDB Entry DOI: 10.7270/Q24J0JFT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Receptor-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human)) | BDBM50233241![]() (CHEMBL4071080) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Queen Mary University of London Curated by ChEMBL | Assay Description Inhibition of human RIP1 (1 to 375 residues) expressed in baculovirus infected insect cells preincubated for 1 hr followed by ATP addition measured a... | J Med Chem 60: 1247-1261 (2017) Article DOI: 10.1021/acs.jmedchem.6b01751 BindingDB Entry DOI: 10.7270/Q2SQ92NR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Receptor-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human)) | BDBM50159697![]() (CHEMBL3785745) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Queen Mary University of London Curated by ChEMBL | Assay Description Inhibition of RIP1 in human U937 cells assessed as reduction in TNFalpha/QVD-Oph-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell via... | J Med Chem 60: 1247-1261 (2017) Article DOI: 10.1021/acs.jmedchem.6b01751 BindingDB Entry DOI: 10.7270/Q2SQ92NR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Receptor-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human)) | BDBM50513016![]() (CHEMBL4514028) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Inhibition of human GST/His-tagged RIP1 (1 to 375 residues) expressed in baculovirus expression system assessed as reduction in autophosphorylation m... | J Med Chem 62: 5096-5110 (2019) Article DOI: 10.1021/acs.jmedchem.9b00318 BindingDB Entry DOI: 10.7270/Q24J0JFT | |||||||||||
More data for this Ligand-Target Pair |
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