Found 414 hits with Last Name = 'ceska' and Initial = 't' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Ribosomal protein S6 kinase alpha-5
(Homo sapiens (Human)) | BDBM50601136
(CHEMBL5177437)Show SMILES NC(=O)C(=C\c1cccc(c1)-c1ncnc2[nH]ccc12)\C#N | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| Purchase
MCE PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 0.251 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.2c00134 BindingDB Entry DOI: 10.7270/Q2J38XNB |
More data for this Ligand-Target Pair | |
Ribosomal protein S6 kinase alpha-5
(Homo sapiens (Human)) | BDBM259876
(US9505766, 81)Show SMILES COc1cc(cc(OC)c1OC)-c1n[nH]c2ccc(\C=C(/C#N)C(=O)NC(C)(C)CO)cc12 Show InChI InChI=1S/C24H26N4O5/c1-24(2,13-29)26-23(30)16(12-25)8-14-6-7-18-17(9-14)21(28-27-18)15-10-19(31-3)22(33-5)20(11-15)32-4/h6-11,29H,13H2,1-5H3,(H,26,30)(H,27,28)/b16-8+ | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| Purchase
MCE PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 0.631 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.2c00134 BindingDB Entry DOI: 10.7270/Q2J38XNB |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4-kinase beta
(Homo sapiens (Human)) | BDBM50457851
(CHEMBL4205416)Show SMILES COc1ccc(NC(=O)N2CCN(CC2)c2nc(N)nc3sc(nc23)-c2cccnc2)cc1 Show InChI InChI=1S/C22H22N8O2S/c1-32-16-6-4-15(5-7-16)25-22(31)30-11-9-29(10-12-30)18-17-20(28-21(23)27-18)33-19(26-17)14-3-2-8-24-13-14/h2-8,13H,9-12H2,1H3,(H,25,31)(H2,23,27,28) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
UCB Pharma
Curated by ChEMBL
| Assay Description Inhibition of recombinant human full length GST-tagged PI4K3beta expressed in baculovirus expression system using PI lipid kinase substrate after 60 ... |
J Med Chem 61: 6705-6723 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00521 BindingDB Entry DOI: 10.7270/Q2FF3W01 |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 10
(Homo sapiens (Human)) | BDBM50271563
(CHEMBL482708 | N-cyclohexyl-4-(H-imidazo[1,2-a]pyr...)Show InChI InChI=1S/C18H21N5/c1-22(14-7-3-2-4-8-14)18-19-11-10-15(21-18)16-13-20-17-9-5-6-12-23(16)17/h5-6,9-14H,2-4,7-8H2,1H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem
Similars
| DrugBank MMDB PDB Article PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
UCB
Curated by ChEMBL
| Assay Description Inhibition of JNK3 (unknown origin) |
Bioorg Med Chem Lett 18: 3291-5 (2008)
Article DOI: 10.1016/j.bmcl.2008.04.039 BindingDB Entry DOI: 10.7270/Q2NZ87FX |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Phosphatidylinositol 4-kinase beta
(Homo sapiens (Human)) | BDBM50457853
(CHEMBL4215340)Show SMILES COc1ccc(NC(=O)N2CCN([C@@H](C)C2)c2nc(N)nc3scnc23)c(C)c1 |r| Show InChI InChI=1S/C19H23N7O2S/c1-11-8-13(28-3)4-5-14(11)22-19(27)25-6-7-26(12(2)9-25)16-15-17(29-10-21-15)24-18(20)23-16/h4-5,8,10,12H,6-7,9H2,1-3H3,(H,22,27)(H2,20,23,24)/t12-/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
UCB Pharma
Curated by ChEMBL
| Assay Description Inhibition of recombinant human full length GST-tagged PI4K3beta expressed in baculovirus expression system using PI lipid kinase substrate after 60 ... |
J Med Chem 61: 6705-6723 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00521 BindingDB Entry DOI: 10.7270/Q2FF3W01 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4-kinase beta
(Homo sapiens (Human)) | BDBM50457851
(CHEMBL4205416)Show SMILES COc1ccc(NC(=O)N2CCN(CC2)c2nc(N)nc3sc(nc23)-c2cccnc2)cc1 Show InChI InChI=1S/C22H22N8O2S/c1-32-16-6-4-15(5-7-16)25-22(31)30-11-9-29(10-12-30)18-17-20(28-21(23)27-18)33-19(26-17)14-3-2-8-24-13-14/h2-8,13H,9-12H2,1H3,(H,25,31)(H2,23,27,28) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
UCB Pharma
Curated by ChEMBL
| Assay Description Inhibition of PI4K3beta in human PBMC assessed as reduction in mitomycin-C treated human RPMI1788 cells-stimulated lymphocyte proliferation by measur... |
J Med Chem 61: 6705-6723 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00521 BindingDB Entry DOI: 10.7270/Q2FF3W01 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4-kinase beta
(Homo sapiens (Human)) | BDBM50457886
(CHEMBL4211696)Show SMILES CNC(=O)c1cc(ccc1Cl)-c1ccnc(c1)C(=O)NCc1cccc(c1)-n1cccn1 Show InChI InChI=1S/C24H20ClN5O2/c1-26-23(31)20-13-17(6-7-21(20)25)18-8-10-27-22(14-18)24(32)28-15-16-4-2-5-19(12-16)30-11-3-9-29-30/h2-14H,15H2,1H3,(H,26,31)(H,28,32) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
UCB Pharma
Curated by ChEMBL
| Assay Description Inhibition of recombinant human full length GST-tagged PI4K3beta expressed in baculovirus expression system using PI lipid kinase substrate after 60 ... |
J Med Chem 61: 6705-6723 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00521 BindingDB Entry DOI: 10.7270/Q2FF3W01 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4-kinase beta
(Homo sapiens (Human)) | BDBM50457855
(CHEMBL4211181)Show SMILES COc1ccc(NC(=O)N2CCN([C@@H](C)C2)c2nc(N)nc3n(C)ncc23)c(C)c1 |r| Show InChI InChI=1S/C20H26N8O2/c1-12-9-14(30-4)5-6-16(12)23-20(29)27-7-8-28(13(2)11-27)18-15-10-22-26(3)17(15)24-19(21)25-18/h5-6,9-10,13H,7-8,11H2,1-4H3,(H,23,29)(H2,21,24,25)/t13-/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
MCE PC cid PC sid PDB UniChem
| PDB Article PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
UCB Pharma
Curated by ChEMBL
| Assay Description Inhibition of recombinant human full length GST-tagged PI4K3beta expressed in baculovirus expression system |
J Med Chem 61: 6705-6723 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00521 BindingDB Entry DOI: 10.7270/Q2FF3W01 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Phosphatidylinositol 4-kinase beta
(Homo sapiens (Human)) | BDBM50457854
(CHEMBL4206816)Show SMILES Cc1ccc(NC(=O)N2CCN(CC2)c2nc(N)nc3sc(nc23)-c2cccnc2)cc1 Show InChI InChI=1S/C22H22N8OS/c1-14-4-6-16(7-5-14)25-22(31)30-11-9-29(10-12-30)18-17-20(28-21(23)27-18)32-19(26-17)15-3-2-8-24-13-15/h2-8,13H,9-12H2,1H3,(H,25,31)(H2,23,27,28) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
MCE PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
UCB Pharma
Curated by ChEMBL
| Assay Description Inhibition of PI4K3beta in human PBMC assessed as reduction in mitomycin-C treated human RPMI1788 cells-stimulated lymphocyte proliferation by measur... |
J Med Chem 61: 6705-6723 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00521 BindingDB Entry DOI: 10.7270/Q2FF3W01 |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 10
(Homo sapiens (Human)) | BDBM50211428
(CHEMBL245936 | N-ethyl-4-(4-(2-phenyl-1H-indol-3-y...)Show SMILES CCNC(=O)N1CCC(CC1)Nc1nccc(n1)-c1c([nH]c2ccccc12)-c1ccccc1 Show InChI InChI=1S/C26H28N6O/c1-2-27-26(33)32-16-13-19(14-17-32)29-25-28-15-12-22(31-25)23-20-10-6-7-11-21(20)30-24(23)18-8-4-3-5-9-18/h3-12,15,19,30H,2,13-14,16-17H2,1H3,(H,27,33)(H,28,29,31) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
UCB
Curated by ChEMBL
| Assay Description Inhibition of JNK3 |
Bioorg Med Chem Lett 17: 3463-7 (2007)
Article DOI: 10.1016/j.bmcl.2007.03.078 BindingDB Entry DOI: 10.7270/Q2959H7W |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 9
(Homo sapiens (Human)) | BDBM50211428
(CHEMBL245936 | N-ethyl-4-(4-(2-phenyl-1H-indol-3-y...)Show SMILES CCNC(=O)N1CCC(CC1)Nc1nccc(n1)-c1c([nH]c2ccccc12)-c1ccccc1 Show InChI InChI=1S/C26H28N6O/c1-2-27-26(33)32-16-13-19(14-17-32)29-25-28-15-12-22(31-25)23-20-10-6-7-11-21(20)30-24(23)18-8-4-3-5-9-18/h3-12,15,19,30H,2,13-14,16-17H2,1H3,(H,27,33)(H,28,29,31) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
UCB
Curated by ChEMBL
| Assay Description Inhibition of JNK2 |
Bioorg Med Chem Lett 17: 3463-7 (2007)
Article DOI: 10.1016/j.bmcl.2007.03.078 BindingDB Entry DOI: 10.7270/Q2959H7W |
More data for this Ligand-Target Pair | |
Ribosomal protein S6 kinase alpha-5
(Homo sapiens (Human)) | BDBM259876
(US9505766, 81)Show SMILES COc1cc(cc(OC)c1OC)-c1n[nH]c2ccc(\C=C(/C#N)C(=O)NC(C)(C)CO)cc12 Show InChI InChI=1S/C24H26N4O5/c1-24(2,13-29)26-23(30)16(12-25)8-14-6-7-18-17(9-14)21(28-27-18)15-10-19(31-3)22(33-5)20(11-15)32-4/h6-11,29H,13H2,1-5H3,(H,26,30)(H,27,28)/b16-8+ | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| Purchase
MCE PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.2c00134 BindingDB Entry DOI: 10.7270/Q2J38XNB |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4-kinase beta
(Homo sapiens (Human)) | BDBM50457867
(CHEMBL4203566)Show SMILES COc1ccc(NC(=O)N2CCN([C@@H](C)C2)c2nc(N)nc3sncc23)c(C)c1 |r| Show InChI InChI=1S/C19H23N7O2S/c1-11-8-13(28-3)4-5-15(11)22-19(27)25-6-7-26(12(2)10-25)16-14-9-21-29-17(14)24-18(20)23-16/h4-5,8-9,12H,6-7,10H2,1-3H3,(H,22,27)(H2,20,23,24)/t12-/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
UCB Pharma
Curated by ChEMBL
| Assay Description Inhibition of recombinant human full length GST-tagged PI4K3beta expressed in baculovirus expression system using PI lipid kinase substrate after 60 ... |
J Med Chem 61: 6705-6723 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00521 BindingDB Entry DOI: 10.7270/Q2FF3W01 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4-kinase beta
(Homo sapiens (Human)) | BDBM50457848
(CHEMBL4215244)Show SMILES COc1ccc(NC(=O)N2CCN([C@@H](C)C2)c2nc(N)nc3sccc23)c(C)c1 |r| Show InChI InChI=1S/C20H24N6O2S/c1-12-10-14(28-3)4-5-16(12)22-20(27)25-7-8-26(13(2)11-25)17-15-6-9-29-18(15)24-19(21)23-17/h4-6,9-10,13H,7-8,11H2,1-3H3,(H,22,27)(H2,21,23,24)/t13-/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
UCB Pharma
Curated by ChEMBL
| Assay Description Inhibition of recombinant human full length GST-tagged PI4K3beta expressed in baculovirus expression system using PI lipid kinase substrate after 60 ... |
J Med Chem 61: 6705-6723 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00521 BindingDB Entry DOI: 10.7270/Q2FF3W01 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4-kinase beta
(Homo sapiens (Human)) | BDBM50005005
(CHEMBL2397317)Show SMILES COc1ccc(cc1OC)-c1c(C)nn2c(NCCN3CCOCC3)cc(C)nc12 Show InChI InChI=1S/C22H29N5O3/c1-15-13-20(23-7-8-26-9-11-30-12-10-26)27-22(24-15)21(16(2)25-27)17-5-6-18(28-3)19(14-17)29-4/h5-6,13-14,23H,7-12H2,1-4H3 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
UCB Pharma
Curated by ChEMBL
| Assay Description Inhibition of recombinant human full length GST-tagged PI4K3beta expressed in baculovirus expression system using PI lipid kinase substrate after 60 ... |
J Med Chem 61: 6705-6723 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00521 BindingDB Entry DOI: 10.7270/Q2FF3W01 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4-kinase beta
(Homo sapiens (Human)) | BDBM50457850
(CHEMBL4203041)Show SMILES COc1ccc(NC(=O)N2CCN([C@@H](C)C2)c2nc(N)nc3scnc23)cc1 |r| Show InChI InChI=1S/C18H21N7O2S/c1-11-9-24(18(26)21-12-3-5-13(27-2)6-4-12)7-8-25(11)15-14-16(28-10-20-14)23-17(19)22-15/h3-6,10-11H,7-9H2,1-2H3,(H,21,26)(H2,19,22,23)/t11-/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
UCB Pharma
Curated by ChEMBL
| Assay Description Inhibition of recombinant human full length GST-tagged PI4K3beta expressed in baculovirus expression system using PI lipid kinase substrate after 60 ... |
J Med Chem 61: 6705-6723 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00521 BindingDB Entry DOI: 10.7270/Q2FF3W01 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4-kinase beta
(Homo sapiens (Human)) | BDBM50457876
(CHEMBL4209793)Show SMILES COc1ccc(NC(=O)N2CCN([C@@H](C)C2)c2nc(N)nc3n(C)cnc23)c(C)c1 |r| Show InChI InChI=1S/C20H26N8O2/c1-12-9-14(30-4)5-6-15(12)23-20(29)27-7-8-28(13(2)10-27)18-16-17(24-19(21)25-18)26(3)11-22-16/h5-6,9,11,13H,7-8,10H2,1-4H3,(H,23,29)(H2,21,24,25)/t13-/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
UCB Pharma
Curated by ChEMBL
| Assay Description Inhibition of recombinant human full length GST-tagged PI4K3beta expressed in baculovirus expression system using PI lipid kinase substrate after 60 ... |
J Med Chem 61: 6705-6723 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00521 BindingDB Entry DOI: 10.7270/Q2FF3W01 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4-kinase beta
(Homo sapiens (Human)) | BDBM50457868
(CHEMBL4202450)Show SMILES Cc1nn2c(NCc3ccnc(C)c3)cc(C)nc2c1-c1ccc(Cl)c(NS(C)(=O)=O)c1 Show InChI InChI=1S/C22H23ClN6O2S/c1-13-9-16(7-8-24-13)12-25-20-10-14(2)26-22-21(15(3)27-29(20)22)17-5-6-18(23)19(11-17)28-32(4,30)31/h5-11,25,28H,12H2,1-4H3 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
UCB Pharma
Curated by ChEMBL
| Assay Description Inhibition of PI4K3beta in human PBMC assessed as reduction in mitomycin-C treated human RPMI1788 cells-stimulated lymphocyte proliferation by measur... |
J Med Chem 61: 6705-6723 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00521 BindingDB Entry DOI: 10.7270/Q2FF3W01 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4-kinase beta
(Homo sapiens (Human)) | BDBM50457853
(CHEMBL4215340)Show SMILES COc1ccc(NC(=O)N2CCN([C@@H](C)C2)c2nc(N)nc3scnc23)c(C)c1 |r| Show InChI InChI=1S/C19H23N7O2S/c1-11-8-13(28-3)4-5-14(11)22-19(27)25-6-7-26(12(2)9-25)16-15-17(29-10-21-15)24-18(20)23-16/h4-5,8,10,12H,6-7,9H2,1-3H3,(H,22,27)(H2,20,23,24)/t12-/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
UCB Pharma
Curated by ChEMBL
| Assay Description Inhibition of PI4K3beta in human PBMC assessed as reduction in mitomycin-C treated human RPMI1788 cells-stimulated lymphocyte proliferation by measur... |
J Med Chem 61: 6705-6723 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00521 BindingDB Entry DOI: 10.7270/Q2FF3W01 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4-kinase beta
(Homo sapiens (Human)) | BDBM50457860
(CHEMBL4207851)Show SMILES COc1ccc(NC(=O)N2CCN(CC2)c2nc(N)nc3scnc23)c(C)c1 Show InChI InChI=1S/C18H21N7O2S/c1-11-9-12(27-2)3-4-13(11)21-18(26)25-7-5-24(6-8-25)15-14-16(28-10-20-14)23-17(19)22-15/h3-4,9-10H,5-8H2,1-2H3,(H,21,26)(H2,19,22,23) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
UCB Pharma
Curated by ChEMBL
| Assay Description GRAC: human Y1 selective antagonist |
J Med Chem 61: 6705-6723 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00521 BindingDB Entry DOI: 10.7270/Q2FF3W01 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4-kinase beta
(Homo sapiens (Human)) | BDBM50457870
(CHEMBL1652677)Show SMILES Nc1nc(N2CCN(CC2)C(=O)COc2ccc(Cl)cc2)c2nc(sc2n1)-c1cccnc1 Show InChI InChI=1S/C22H20ClN7O2S/c23-15-3-5-16(6-4-15)32-13-17(31)29-8-10-30(11-9-29)19-18-21(28-22(24)27-19)33-20(26-18)14-2-1-7-25-12-14/h1-7,12H,8-11,13H2,(H2,24,27,28) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
UCB Pharma
Curated by ChEMBL
| Assay Description Inhibition of recombinant human full length GST-tagged PI4K3beta expressed in baculovirus expression system using PI lipid kinase substrate after 60 ... |
J Med Chem 61: 6705-6723 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00521 BindingDB Entry DOI: 10.7270/Q2FF3W01 |
More data for this Ligand-Target Pair | |
Ribosomal protein S6 kinase alpha-5
(Homo sapiens (Human)) | BDBM50601139
(CHEMBL5190298) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.2c00134 BindingDB Entry DOI: 10.7270/Q2J38XNB |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4-kinase beta
(Homo sapiens (Human)) | BDBM50457871
(CHEMBL4210308)Show SMILES COc1ccc(NC(=O)N2CCN(CC2)c2nc(N)nc3sc(nc23)-c2ccccc2)cc1 Show InChI InChI=1S/C23H23N7O2S/c1-32-17-9-7-16(8-10-17)25-23(31)30-13-11-29(12-14-30)19-18-21(28-22(24)27-19)33-20(26-18)15-5-3-2-4-6-15/h2-10H,11-14H2,1H3,(H,25,31)(H2,24,27,28) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
UCB Pharma
Curated by ChEMBL
| Assay Description Inhibition of recombinant human full length GST-tagged PI4K3beta expressed in baculovirus expression system using PI lipid kinase substrate after 60 ... |
J Med Chem 61: 6705-6723 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00521 BindingDB Entry DOI: 10.7270/Q2FF3W01 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4-kinase beta
(Homo sapiens (Human)) | BDBM50457855
(CHEMBL4211181)Show SMILES COc1ccc(NC(=O)N2CCN([C@@H](C)C2)c2nc(N)nc3n(C)ncc23)c(C)c1 |r| Show InChI InChI=1S/C20H26N8O2/c1-12-9-14(30-4)5-6-16(12)23-20(29)27-7-8-28(13(2)11-27)18-15-10-22-26(3)17(15)24-19(21)25-18/h5-6,9-10,13H,7-8,11H2,1-4H3,(H,23,29)(H2,21,24,25)/t13-/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
MCE PC cid PC sid PDB UniChem
| PDB Article PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
UCB Pharma
Curated by ChEMBL
| Assay Description Inhibition of recombinant human full length GST-tagged PI4K3beta expressed in baculovirus expression system using PI lipid kinase substrate after 60 ... |
J Med Chem 61: 6705-6723 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00521 BindingDB Entry DOI: 10.7270/Q2FF3W01 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Phosphatidylinositol 4-kinase beta
(Homo sapiens (Human)) | BDBM50457848
(CHEMBL4215244)Show SMILES COc1ccc(NC(=O)N2CCN([C@@H](C)C2)c2nc(N)nc3sccc23)c(C)c1 |r| Show InChI InChI=1S/C20H24N6O2S/c1-12-10-14(28-3)4-5-16(12)22-20(27)25-7-8-26(13(2)11-25)17-15-6-9-29-18(15)24-19(21)23-17/h4-6,9-10,13H,7-8,11H2,1-3H3,(H,22,27)(H2,21,23,24)/t13-/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
UCB Pharma
Curated by ChEMBL
| Assay Description Inhibition of PI4K3beta in human PBMC assessed as reduction in mitomycin-C treated human RPMI1788 cells-stimulated lymphocyte proliferation by measur... |
J Med Chem 61: 6705-6723 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00521 BindingDB Entry DOI: 10.7270/Q2FF3W01 |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 8
(Homo sapiens (Human)) | BDBM50211424
(4-(5-chloro-4-(1H-indol-3-yl)pyrimidin-2-ylamino)-...)Show SMILES CCNC(=O)N1CCC(CC1)Nc1ncc(Cl)c(n1)-c1c[nH]c2ccccc12 Show InChI InChI=1S/C20H23ClN6O/c1-2-22-20(28)27-9-7-13(8-10-27)25-19-24-12-16(21)18(26-19)15-11-23-17-6-4-3-5-14(15)17/h3-6,11-13,23H,2,7-10H2,1H3,(H,22,28)(H,24,25,26) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem
Similars
| MMDB PDB Article PubMed
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
UCB
Curated by ChEMBL
| Assay Description Inhibition of JNK1 |
Bioorg Med Chem Lett 17: 3463-7 (2007)
Article DOI: 10.1016/j.bmcl.2007.03.078 BindingDB Entry DOI: 10.7270/Q2959H7W |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Mitogen-activated protein kinase 8
(Homo sapiens (Human)) | BDBM50211436
(2-(4-(5-chloro-4-(1H-indol-3-yl)pyrimidin-2-ylamin...)Show SMILES CNC(=O)CN1CCC(CC1)Nc1ncc(Cl)c(n1)-c1c[nH]c2ccccc12 Show InChI InChI=1S/C20H23ClN6O/c1-22-18(28)12-27-8-6-13(7-9-27)25-20-24-11-16(21)19(26-20)15-10-23-17-5-3-2-4-14(15)17/h2-5,10-11,13,23H,6-9,12H2,1H3,(H,22,28)(H,24,25,26) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
UCB
Curated by ChEMBL
| Assay Description Inhibition of JNK1 |
Bioorg Med Chem Lett 17: 3463-7 (2007)
Article DOI: 10.1016/j.bmcl.2007.03.078 BindingDB Entry DOI: 10.7270/Q2959H7W |
More data for this Ligand-Target Pair | |
Ribosomal protein S6 kinase alpha-5
(Homo sapiens (Human)) | BDBM50601138
(CHEMBL5184056) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| PC cid PC sid PDB UniChem
| PDB Article PubMed
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.2c00134 BindingDB Entry DOI: 10.7270/Q2J38XNB |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Mitogen-activated protein kinase 10
(Homo sapiens (Human)) | BDBM50211436
(2-(4-(5-chloro-4-(1H-indol-3-yl)pyrimidin-2-ylamin...)Show SMILES CNC(=O)CN1CCC(CC1)Nc1ncc(Cl)c(n1)-c1c[nH]c2ccccc12 Show InChI InChI=1S/C20H23ClN6O/c1-22-18(28)12-27-8-6-13(7-9-27)25-20-24-11-16(21)19(26-20)15-10-23-17-5-3-2-4-14(15)17/h2-5,10-11,13,23H,6-9,12H2,1H3,(H,22,28)(H,24,25,26) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
UCB
Curated by ChEMBL
| Assay Description Inhibition of JNK3 |
Bioorg Med Chem Lett 17: 3463-7 (2007)
Article DOI: 10.1016/j.bmcl.2007.03.078 BindingDB Entry DOI: 10.7270/Q2959H7W |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 9
(Homo sapiens (Human)) | BDBM50211430
((4-(5-chloro-4-(1H-indol-3-yl)pyrimidin-2-ylamino)...)Show SMILES CC1CCN(CC1)C(=O)N1CCC(CC1)Nc1ncc(Cl)c(n1)-c1c[nH]c2ccccc12 Show InChI InChI=1S/C24H29ClN6O/c1-16-6-10-30(11-7-16)24(32)31-12-8-17(9-13-31)28-23-27-15-20(25)22(29-23)19-14-26-21-5-3-2-4-18(19)21/h2-5,14-17,26H,6-13H2,1H3,(H,27,28,29) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
UCB
Curated by ChEMBL
| Assay Description Inhibition of JNK2 |
Bioorg Med Chem Lett 17: 3463-7 (2007)
Article DOI: 10.1016/j.bmcl.2007.03.078 BindingDB Entry DOI: 10.7270/Q2959H7W |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 8
(Homo sapiens (Human)) | BDBM50211438
(4-(5-chloro-4-(1H-indol-3-yl)pyrimidin-2-ylamino)-...)Show SMILES CN(C)C(=O)N1CCC(CC1)Nc1ncc(Cl)c(n1)-c1c[nH]c2ccccc12 Show InChI InChI=1S/C20H23ClN6O/c1-26(2)20(28)27-9-7-13(8-10-27)24-19-23-12-16(21)18(25-19)15-11-22-17-6-4-3-5-14(15)17/h3-6,11-13,22H,7-10H2,1-2H3,(H,23,24,25) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
UCB
Curated by ChEMBL
| Assay Description Inhibition of JNK1 |
Bioorg Med Chem Lett 17: 3463-7 (2007)
Article DOI: 10.1016/j.bmcl.2007.03.078 BindingDB Entry DOI: 10.7270/Q2959H7W |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 8
(Homo sapiens (Human)) | BDBM50211426
(2-((R)-3-(5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl...)Show SMILES CNC(=O)CN1CCC[C@H](C1)Nc1ncc(Cl)c(n1)-c1c[nH]c2ccccc12 Show InChI InChI=1S/C20H23ClN6O/c1-22-18(28)12-27-8-4-5-13(11-27)25-20-24-10-16(21)19(26-20)15-9-23-17-7-3-2-6-14(15)17/h2-3,6-7,9-10,13,23H,4-5,8,11-12H2,1H3,(H,22,28)(H,24,25,26)/t13-/m1/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
UCB
Curated by ChEMBL
| Assay Description Inhibition of JNK1 |
Bioorg Med Chem Lett 17: 3463-7 (2007)
Article DOI: 10.1016/j.bmcl.2007.03.078 BindingDB Entry DOI: 10.7270/Q2959H7W |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 9
(Homo sapiens (Human)) | BDBM50211443
((3S)-3-(5-chloro-4-(1H-indol-3-yl)pyrimidin-2-ylam...)Show SMILES CCNC(=O)N1CCC[C@@H](C1)Nc1ncc(Cl)c(n1)-c1c[nH]c2ccccc12 Show InChI InChI=1S/C20H23ClN6O/c1-2-22-20(28)27-9-5-6-13(12-27)25-19-24-11-16(21)18(26-19)15-10-23-17-8-4-3-7-14(15)17/h3-4,7-8,10-11,13,23H,2,5-6,9,12H2,1H3,(H,22,28)(H,24,25,26)/t13-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
UCB
Curated by ChEMBL
| Assay Description Inhibition of JNK2 |
Bioorg Med Chem Lett 17: 3463-7 (2007)
Article DOI: 10.1016/j.bmcl.2007.03.078 BindingDB Entry DOI: 10.7270/Q2959H7W |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 8
(Homo sapiens (Human)) | BDBM50211430
((4-(5-chloro-4-(1H-indol-3-yl)pyrimidin-2-ylamino)...)Show SMILES CC1CCN(CC1)C(=O)N1CCC(CC1)Nc1ncc(Cl)c(n1)-c1c[nH]c2ccccc12 Show InChI InChI=1S/C24H29ClN6O/c1-16-6-10-30(11-7-16)24(32)31-12-8-17(9-13-31)28-23-27-15-20(25)22(29-23)19-14-26-21-5-3-2-4-18(19)21/h2-5,14-17,26H,6-13H2,1H3,(H,27,28,29) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
UCB
Curated by ChEMBL
| Assay Description Inhibition of JNK1 |
Bioorg Med Chem Lett 17: 3463-7 (2007)
Article DOI: 10.1016/j.bmcl.2007.03.078 BindingDB Entry DOI: 10.7270/Q2959H7W |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4-kinase beta
(Homo sapiens (Human)) | BDBM50457870
(CHEMBL1652677)Show SMILES Nc1nc(N2CCN(CC2)C(=O)COc2ccc(Cl)cc2)c2nc(sc2n1)-c1cccnc1 Show InChI InChI=1S/C22H20ClN7O2S/c23-15-3-5-16(6-4-15)32-13-17(31)29-8-10-30(11-9-29)19-18-21(28-22(24)27-19)33-20(26-18)14-2-1-7-25-12-14/h1-7,12H,8-11,13H2,(H2,24,27,28) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
UCB Pharma
Curated by ChEMBL
| Assay Description Inhibition of PI4K3beta in human PBMC assessed as reduction in mitomycin-C treated human RPMI1788 cells-stimulated lymphocyte proliferation by measur... |
J Med Chem 61: 6705-6723 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00521 BindingDB Entry DOI: 10.7270/Q2FF3W01 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM50262173
(2-(6-(1H-pyrazol-4-yl)-2,3-dihydrobenzo[b][1,4]oxa...)Show SMILES CC1(C)Cc2nc(sc2C(=O)N1)N1CCOc2ccc(cc12)-c1cn[nH]c1 Show InChI InChI=1S/C19H19N5O2S/c1-19(2)8-13-16(17(25)23-19)27-18(22-13)24-5-6-26-15-4-3-11(7-14(15)24)12-9-20-21-10-12/h3-4,7,9-10H,5-6,8H2,1-2H3,(H,20,21)(H,23,25) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
UCB
Curated by ChEMBL
| Assay Description Inhibition of PI3K delta (unknown origin) |
Bioorg Med Chem Lett 18: 4700-4 (2008)
Article DOI: 10.1016/j.bmcl.2008.06.104 BindingDB Entry DOI: 10.7270/Q2VM4C2J |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM50262174
(2-(6-(1H-pyrazol-4-yl)-2,3-dihydrobenzo[b][1,4]oxa...)Show SMILES CC1(C)Cc2nc(sc2C(=O)C1)N1CCOc2ccc(cc12)-c1cn[nH]c1 Show InChI InChI=1S/C20H20N4O2S/c1-20(2)8-14-18(16(25)9-20)27-19(23-14)24-5-6-26-17-4-3-12(7-15(17)24)13-10-21-22-11-13/h3-4,7,10-11H,5-6,8-9H2,1-2H3,(H,21,22) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
UCB
Curated by ChEMBL
| Assay Description Inhibition of PI3K delta (unknown origin) |
Bioorg Med Chem Lett 18: 4700-4 (2008)
Article DOI: 10.1016/j.bmcl.2008.06.104 BindingDB Entry DOI: 10.7270/Q2VM4C2J |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4-kinase beta
(Homo sapiens (Human)) | BDBM50457886
(CHEMBL4211696)Show SMILES CNC(=O)c1cc(ccc1Cl)-c1ccnc(c1)C(=O)NCc1cccc(c1)-n1cccn1 Show InChI InChI=1S/C24H20ClN5O2/c1-26-23(31)20-13-17(6-7-21(20)25)18-8-10-27-22(14-18)24(32)28-15-16-4-2-5-19(12-16)30-11-3-9-29-30/h2-14H,15H2,1H3,(H,26,31)(H,28,32) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 18 | n/a | n/a | n/a | n/a | n/a | n/a |
UCB Pharma
Curated by ChEMBL
| Assay Description Inhibition of PI4K3beta in human PBMC assessed as reduction in mitomycin-C treated human RPMI1788 cells-stimulated lymphocyte proliferation by measur... |
J Med Chem 61: 6705-6723 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00521 BindingDB Entry DOI: 10.7270/Q2FF3W01 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4-kinase beta
(Homo sapiens (Human)) | BDBM50457862
(CHEMBL4204100)Show SMILES COc1ccc(NC(=O)N2CCN(C(C)C2)c2nc(N)nc3scnc23)cc1 Show InChI InChI=1S/C18H21N7O2S/c1-11-9-24(18(26)21-12-3-5-13(27-2)6-4-12)7-8-25(11)15-14-16(28-10-20-14)23-17(19)22-15/h3-6,10-11H,7-9H2,1-2H3,(H,21,26)(H2,19,22,23) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 18 | n/a | n/a | n/a | n/a | n/a | n/a |
UCB Pharma
Curated by ChEMBL
| Assay Description Inhibition of recombinant human full length GST-tagged PI4K3beta expressed in baculovirus expression system using PI lipid kinase substrate after 60 ... |
J Med Chem 61: 6705-6723 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00521 BindingDB Entry DOI: 10.7270/Q2FF3W01 |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 8
(Homo sapiens (Human)) | BDBM50211429
((4-(5-chloro-4-(1H-indol-3-yl)pyrimidin-2-ylamino)...)Show SMILES CN1CCN(CC1)C(=O)N1CCC(CC1)Nc1ncc(Cl)c(n1)-c1c[nH]c2ccccc12 Show InChI InChI=1S/C23H28ClN7O/c1-29-10-12-31(13-11-29)23(32)30-8-6-16(7-9-30)27-22-26-15-19(24)21(28-22)18-14-25-20-5-3-2-4-17(18)20/h2-5,14-16,25H,6-13H2,1H3,(H,26,27,28) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 18 | n/a | n/a | n/a | n/a | n/a | n/a |
UCB
Curated by ChEMBL
| Assay Description Inhibition of JNK1 |
Bioorg Med Chem Lett 17: 3463-7 (2007)
Article DOI: 10.1016/j.bmcl.2007.03.078 BindingDB Entry DOI: 10.7270/Q2959H7W |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4-kinase beta
(Homo sapiens (Human)) | BDBM50042924
(CHEMBL1229535)Show SMILES CC(=O)\N=c1\[nH]c(C)c(s1)-c1ccc(Cl)c(c1)S(=O)(=O)NCCO Show InChI InChI=1S/C14H16ClN3O4S2/c1-8-13(23-14(17-8)18-9(2)20)10-3-4-11(15)12(7-10)24(21,22)16-5-6-19/h3-4,7,16,19H,5-6H2,1-2H3,(H,17,18,20) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL DrugBank PC cid PC sid PDB UniChem
Similars
| PDB Article PubMed
| n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
UCB Pharma
Curated by ChEMBL
| Assay Description Inhibition of PI4K3beta (unknown origin) |
J Med Chem 61: 6705-6723 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00521 BindingDB Entry DOI: 10.7270/Q2FF3W01 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Phosphatidylinositol 4-kinase beta
(Homo sapiens (Human)) | BDBM50457854
(CHEMBL4206816)Show SMILES Cc1ccc(NC(=O)N2CCN(CC2)c2nc(N)nc3sc(nc23)-c2cccnc2)cc1 Show InChI InChI=1S/C22H22N8OS/c1-14-4-6-16(7-5-14)25-22(31)30-11-9-29(10-12-30)18-17-20(28-21(23)27-18)32-19(26-17)15-3-2-8-24-13-15/h2-8,13H,9-12H2,1H3,(H,25,31)(H2,23,27,28) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
MCE PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
UCB Pharma
Curated by ChEMBL
| Assay Description Inhibition of recombinant human full length GST-tagged PI4K3beta expressed in baculovirus expression system using PI lipid kinase substrate after 60 ... |
J Med Chem 61: 6705-6723 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00521 BindingDB Entry DOI: 10.7270/Q2FF3W01 |
More data for this Ligand-Target Pair | |
Ribosomal protein S6 kinase alpha-5
(Homo sapiens (Human)) | BDBM50601140
(CHEMBL5183170) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.2c00134 BindingDB Entry DOI: 10.7270/Q2J38XNB |
More data for this Ligand-Target Pair | |
Ribosomal protein S6 kinase alpha-5
(Homo sapiens (Human)) | BDBM50601158
(CHEMBL5186781) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.2c00134 BindingDB Entry DOI: 10.7270/Q2J38XNB |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4-kinase beta
(Homo sapiens (Human)) | BDBM50457866
(CHEMBL4207928)Show SMILES COc1ccc(NC(=O)N2CCN([C@@H](C)C2)c2nc(N)nc3scnc23)c(C)n1 |r| Show InChI InChI=1S/C18H22N8O2S/c1-10-8-25(18(27)22-12-4-5-13(28-3)21-11(12)2)6-7-26(10)15-14-16(29-9-20-14)24-17(19)23-15/h4-5,9-10H,6-8H2,1-3H3,(H,22,27)(H2,19,23,24)/t10-/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
UCB Pharma
Curated by ChEMBL
| Assay Description Inhibition of recombinant human full length GST-tagged PI4K3beta expressed in baculovirus expression system using PI lipid kinase substrate after 60 ... |
J Med Chem 61: 6705-6723 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00521 BindingDB Entry DOI: 10.7270/Q2FF3W01 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM50261783
(5,5-dimethyl-2-(6-(pyridin-3-yl)-2,3-dihydrobenzo[...)Show SMILES CC1(C)Cc2nc(sc2C(=O)C1)N1CCOc2ccc(cc12)-c1cccnc1 Show InChI InChI=1S/C22H21N3O2S/c1-22(2)11-16-20(18(26)12-22)28-21(24-16)25-8-9-27-19-6-5-14(10-17(19)25)15-4-3-7-23-13-15/h3-7,10,13H,8-9,11-12H2,1-2H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
UCB
Curated by ChEMBL
| Assay Description Inhibition of PI3K delta (unknown origin) |
Bioorg Med Chem Lett 18: 4700-4 (2008)
Article DOI: 10.1016/j.bmcl.2008.06.104 BindingDB Entry DOI: 10.7270/Q2VM4C2J |
More data for this Ligand-Target Pair | |
Ribosomal protein S6 kinase alpha-4
(Homo sapiens (Human)) | BDBM50601138
(CHEMBL5184056) | NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid PDB UniChem
| Article PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.2c00134 BindingDB Entry DOI: 10.7270/Q2J38XNB |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM50261838
(6,6-dimethyl-2-(6-(6-methylpyridin-3-yl)-2,3-dihyd...)Show SMILES Cc1ccc(cn1)-c1ccc2OCCN(c3nc4CC(C)(C)NC(=O)c4s3)c2c1 Show InChI InChI=1S/C22H22N4O2S/c1-13-4-5-15(12-23-13)14-6-7-18-17(10-14)26(8-9-28-18)21-24-16-11-22(2,3)25-20(27)19(16)29-21/h4-7,10,12H,8-9,11H2,1-3H3,(H,25,27) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 21 | n/a | n/a | n/a | n/a | n/a | n/a |
UCB
Curated by ChEMBL
| Assay Description Inhibition of PI3K delta (unknown origin) |
Bioorg Med Chem Lett 18: 4700-4 (2008)
Article DOI: 10.1016/j.bmcl.2008.06.104 BindingDB Entry DOI: 10.7270/Q2VM4C2J |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 8
(Homo sapiens (Human)) | BDBM50211428
(CHEMBL245936 | N-ethyl-4-(4-(2-phenyl-1H-indol-3-y...)Show SMILES CCNC(=O)N1CCC(CC1)Nc1nccc(n1)-c1c([nH]c2ccccc12)-c1ccccc1 Show InChI InChI=1S/C26H28N6O/c1-2-27-26(33)32-16-13-19(14-17-32)29-25-28-15-12-22(31-25)23-20-10-6-7-11-21(20)30-24(23)18-8-4-3-5-9-18/h3-12,15,19,30H,2,13-14,16-17H2,1H3,(H,27,33)(H,28,29,31) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 22 | n/a | n/a | n/a | n/a | n/a | n/a |
UCB
Curated by ChEMBL
| Assay Description Inhibition of JNK1 |
Bioorg Med Chem Lett 17: 3463-7 (2007)
Article DOI: 10.1016/j.bmcl.2007.03.078 BindingDB Entry DOI: 10.7270/Q2959H7W |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
(Homo sapiens (Human)) | BDBM50262173
(2-(6-(1H-pyrazol-4-yl)-2,3-dihydrobenzo[b][1,4]oxa...)Show SMILES CC1(C)Cc2nc(sc2C(=O)N1)N1CCOc2ccc(cc12)-c1cn[nH]c1 Show InChI InChI=1S/C19H19N5O2S/c1-19(2)8-13-16(17(25)23-19)27-18(22-13)24-5-6-26-15-4-3-11(7-14(15)24)12-9-20-21-10-12/h3-4,7,9-10H,5-6,8H2,1-2H3,(H,20,21)(H,23,25) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 22 | n/a | n/a | n/a | n/a | n/a | n/a |
UCB
Curated by ChEMBL
| Assay Description Inhibition of PI3K gamma (unknown origin) |
Bioorg Med Chem Lett 18: 4700-4 (2008)
Article DOI: 10.1016/j.bmcl.2008.06.104 BindingDB Entry DOI: 10.7270/Q2VM4C2J |
More data for this Ligand-Target Pair | |