Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
D(2) dopamine receptor (Rattus norvegicus (rat)) | BDBM194790 (US9206167, 11 | US9206167, 12 | USRE48059, Compoun...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Otsuka Pharmaceutical Co., Ltd. US Patent | Assay Description Dopamine D2: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-raclopride (final concentration 1 to 2 nM)... | US Patent USRE48059 (2020) BindingDB Entry DOI: 10.7270/Q2833W3C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Rattus norvegicus (rat)) | BDBM194790 (US9206167, 11 | US9206167, 12 | USRE48059, Compoun...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Otsuka Pharmaceutical Co., Ltd. US Patent | Assay Description Dopamine D2: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-raclopride (final concentration 1 to 2 nM)... | US Patent USRE48059 (2020) BindingDB Entry DOI: 10.7270/Q2833W3C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Rattus norvegicus (rat)) | BDBM194790 (US9206167, 11 | US9206167, 12 | USRE48059, Compoun...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.100 | -57.1 | n/a | n/a | n/a | n/a | n/a | 7.4 | 25 |
OTSUKA PHARMACEUTICAL CO., LTD. US Patent | Assay Description The assay was performed according to the method by Kohler et al. (Kohler C, Hall H, Ogren S O and Gawell L, Specific in vitro and in vivo binding of ... | US Patent US9206167 (2015) BindingDB Entry DOI: 10.7270/Q2XD10GS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Rattus norvegicus (rat)) | BDBM194790 (US9206167, 11 | US9206167, 12 | USRE48059, Compoun...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.100 | -57.1 | n/a | n/a | n/a | n/a | n/a | 7.4 | 25 |
OTSUKA PHARMACEUTICAL CO., LTD. US Patent | Assay Description The assay was performed according to the method by Kohler et al. (Kohler C, Hall H, Ogren S O and Gawell L, Specific in vitro and in vivo binding of ... | US Patent US9206167 (2015) BindingDB Entry DOI: 10.7270/Q2XD10GS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Rattus norvegicus (rat)) | BDBM194772 (US9206167, 139) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.200 | -55.4 | n/a | n/a | n/a | n/a | n/a | 7.4 | 25 |
OTSUKA PHARMACEUTICAL CO., LTD. US Patent | Assay Description The assay was performed according to the method by Kohler et al. (Kohler C, Hall H, Ogren S O and Gawell L, Specific in vitro and in vivo binding of ... | US Patent US9206167 (2015) BindingDB Entry DOI: 10.7270/Q2XD10GS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Rattus norvegicus (rat)) | BDBM194794 (US9206167, 15 | USRE48059, Compound of Example 15) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Otsuka Pharmaceutical Co., Ltd. US Patent | Assay Description Dopamine D2: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-raclopride (final concentration 1 to 2 nM)... | US Patent USRE48059 (2020) BindingDB Entry DOI: 10.7270/Q2833W3C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Rattus norvegicus (rat)) | BDBM194780 (7-(4-(4-(1-benzothiophen-4-yl)piperazin-1-yl)butox...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase DrugBank MCE PC cid PC sid UniChem | US Patent | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Otsuka Pharmaceutical Co., Ltd. US Patent | Assay Description Dopamine D2: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-raclopride (final concentration 1 to 2 nM)... | US Patent USRE48059 (2020) BindingDB Entry DOI: 10.7270/Q2833W3C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Rattus norvegicus (rat)) | BDBM194780 (7-(4-(4-(1-benzothiophen-4-yl)piperazin-1-yl)butox...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase DrugBank MCE PC cid PC sid UniChem | US Patent | 0.200 | -55.4 | n/a | n/a | n/a | n/a | n/a | 7.4 | 25 |
OTSUKA PHARMACEUTICAL CO., LTD. US Patent | Assay Description The assay was performed according to the method by Kohler et al. (Kohler C, Hall H, Ogren S O and Gawell L, Specific in vitro and in vivo binding of ... | US Patent US9206167 (2015) BindingDB Entry DOI: 10.7270/Q2XD10GS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Rattus norvegicus (rat)) | BDBM448338 (USRE48059, Compound of Example 139) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Otsuka Pharmaceutical Co., Ltd. US Patent | Assay Description Dopamine D2: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-raclopride (final concentration 1 to 2 nM)... | US Patent USRE48059 (2020) BindingDB Entry DOI: 10.7270/Q2833W3C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Rattus norvegicus (rat)) | BDBM194794 (US9206167, 15 | USRE48059, Compound of Example 15) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.200 | -55.4 | n/a | n/a | n/a | n/a | n/a | 7.4 | 25 |
OTSUKA PHARMACEUTICAL CO., LTD. US Patent | Assay Description The assay was performed according to the method by Kohler et al. (Kohler C, Hall H, Ogren S O and Gawell L, Specific in vitro and in vivo binding of ... | US Patent US9206167 (2015) BindingDB Entry DOI: 10.7270/Q2XD10GS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-1A adrenergic receptor (Homo sapiens (Human)) | BDBM29568 (CHEMBL2 | PRAZOSIN | PRAZOSIN HYDROCHLORIDE | [3H]...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | DrugBank Article PubMed | 0.210 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Children's Medical Research Center, Tokyo Curated by PDSP Ki Database | Biochem Biophys Res Commun 195: 902-9 (1993) Article DOI: 10.1006/bbrc.1993.2130 BindingDB Entry DOI: 10.7270/Q2FQ9V30 | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-1A adrenergic receptor (Homo sapiens (Human)) | BDBM81444 (CAS_185453 | NSC_185453 | WB 4101 | WB-4101) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | 0.230 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Children's Medical Research Center, Tokyo Curated by PDSP Ki Database | Biochem Biophys Res Commun 195: 902-9 (1993) Article DOI: 10.1006/bbrc.1993.2130 BindingDB Entry DOI: 10.7270/Q2FQ9V30 | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Rattus norvegicus (rat)) | BDBM194764 (US9206167, 90) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.400 | -53.6 | n/a | n/a | n/a | n/a | n/a | 7.4 | 25 |
OTSUKA PHARMACEUTICAL CO., LTD. US Patent | Assay Description The assay was performed according to the method by Kohler et al. (Kohler C, Hall H, Ogren S O and Gawell L, Specific in vitro and in vivo binding of ... | US Patent US9206167 (2015) BindingDB Entry DOI: 10.7270/Q2XD10GS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Rattus norvegicus (rat)) | BDBM194789 (US9206167, 10 | USRE48059, Compound of Example 10) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.400 | -53.6 | n/a | n/a | n/a | n/a | n/a | 7.4 | 25 |
OTSUKA PHARMACEUTICAL CO., LTD. US Patent | Assay Description The assay was performed according to the method by Kohler et al. (Kohler C, Hall H, Ogren S O and Gawell L, Specific in vitro and in vivo binding of ... | US Patent US9206167 (2015) BindingDB Entry DOI: 10.7270/Q2XD10GS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Rattus norvegicus (rat)) | BDBM448330 (USRE48059, Compound of Example 90) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Otsuka Pharmaceutical Co., Ltd. US Patent | Assay Description Dopamine D2: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-raclopride (final concentration 1 to 2 nM)... | US Patent USRE48059 (2020) BindingDB Entry DOI: 10.7270/Q2833W3C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Rattus norvegicus (rat)) | BDBM194789 (US9206167, 10 | USRE48059, Compound of Example 10) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Otsuka Pharmaceutical Co., Ltd. US Patent | Assay Description Dopamine D2: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-raclopride (final concentration 1 to 2 nM)... | US Patent USRE48059 (2020) BindingDB Entry DOI: 10.7270/Q2833W3C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Orexin receptor type 2 (Homo sapiens (Human)) | BDBM50093793 (E-2006 | Lemborexant) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem | PDB Article PubMed | 0.440 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Co., Ltd. Curated by ChEMBL | Assay Description Binding affinity to human OX2R expressed in HEK-293 cells assessed as inhibition of orexin A-induced calcium accumulation by FLIPR assay | J Med Chem 58: 4648-64 (2015) Article DOI: 10.1021/acs.jmedchem.5b00217 BindingDB Entry DOI: 10.7270/Q2125VD7 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
D(2) dopamine receptor (Rattus norvegicus (rat)) | BDBM194786 (US9206167, 7 | USRE48059, Compound of Example 7) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Otsuka Pharmaceutical Co., Ltd. US Patent | Assay Description Dopamine D2: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-raclopride (final concentration 1 to 2 nM)... | US Patent USRE48059 (2020) BindingDB Entry DOI: 10.7270/Q2833W3C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Rattus norvegicus (rat)) | BDBM194783 (US9206167, 4 | USRE48059, Compound of Example 4) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Otsuka Pharmaceutical Co., Ltd. US Patent | Assay Description Dopamine D2: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-raclopride (final concentration 1 to 2 nM)... | US Patent USRE48059 (2020) BindingDB Entry DOI: 10.7270/Q2833W3C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Rattus norvegicus (rat)) | BDBM194782 (US9206167, 3 | USRE48059, Compound of Example 3) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Otsuka Pharmaceutical Co., Ltd. US Patent | Assay Description Dopamine D2: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-raclopride (final concentration 1 to 2 nM)... | US Patent USRE48059 (2020) BindingDB Entry DOI: 10.7270/Q2833W3C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Rattus norvegicus (rat)) | BDBM194786 (US9206167, 7 | USRE48059, Compound of Example 7) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.5 | -53.1 | n/a | n/a | n/a | n/a | n/a | 7.4 | 25 |
OTSUKA PHARMACEUTICAL CO., LTD. US Patent | Assay Description The assay was performed according to the method by Kohler et al. (Kohler C, Hall H, Ogren S O and Gawell L, Specific in vitro and in vivo binding of ... | US Patent US9206167 (2015) BindingDB Entry DOI: 10.7270/Q2XD10GS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Rattus norvegicus (rat)) | BDBM194783 (US9206167, 4 | USRE48059, Compound of Example 4) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.5 | -53.1 | n/a | n/a | n/a | n/a | n/a | 7.4 | 25 |
OTSUKA PHARMACEUTICAL CO., LTD. US Patent | Assay Description The assay was performed according to the method by Kohler et al. (Kohler C, Hall H, Ogren S O and Gawell L, Specific in vitro and in vivo binding of ... | US Patent US9206167 (2015) BindingDB Entry DOI: 10.7270/Q2XD10GS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Rattus norvegicus (rat)) | BDBM194782 (US9206167, 3 | USRE48059, Compound of Example 3) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.5 | -53.1 | n/a | n/a | n/a | n/a | n/a | 7.4 | 25 |
OTSUKA PHARMACEUTICAL CO., LTD. US Patent | Assay Description The assay was performed according to the method by Kohler et al. (Kohler C, Hall H, Ogren S O and Gawell L, Specific in vitro and in vivo binding of ... | US Patent US9206167 (2015) BindingDB Entry DOI: 10.7270/Q2XD10GS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 2A (Rattus norvegicus (rat)) | BDBM194787 (US9206167, 8 | USRE48059, Compound of Example 8) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.600 | -54.8 | n/a | n/a | n/a | n/a | n/a | 7.4 | 37 |
OTSUKA PHARMACEUTICAL CO., LTD. US Patent | Assay Description The assay was performed according to the method by Leysen J E et al. (Leysen J E, Niemegeers C J E, Van Nueten J M and Laduron P M. [3H] Ketanserin (... | US Patent US9206167 (2015) BindingDB Entry DOI: 10.7270/Q2XD10GS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Rattus norvegicus (rat)) | BDBM194784 (US9206167, 5 | USRE48059, Compound of Example 5) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.600 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Otsuka Pharmaceutical Co., Ltd. US Patent | Assay Description Dopamine D2: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-raclopride (final concentration 1 to 2 nM)... | US Patent USRE48059 (2020) BindingDB Entry DOI: 10.7270/Q2833W3C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Rattus norvegicus (rat)) | BDBM194784 (US9206167, 5 | USRE48059, Compound of Example 5) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.600 | -52.6 | n/a | n/a | n/a | n/a | n/a | 7.4 | 25 |
OTSUKA PHARMACEUTICAL CO., LTD. US Patent | Assay Description The assay was performed according to the method by Kohler et al. (Kohler C, Hall H, Ogren S O and Gawell L, Specific in vitro and in vivo binding of ... | US Patent US9206167 (2015) BindingDB Entry DOI: 10.7270/Q2XD10GS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 2A (Rattus norvegicus (rat)) | BDBM194787 (US9206167, 8 | USRE48059, Compound of Example 8) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.600 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Otsuka Pharmaceutical Co., Ltd. US Patent | Assay Description 5-HT2A: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-Ketanserin (final concentration 1 to 3 nM), 20 ... | US Patent USRE48059 (2020) BindingDB Entry DOI: 10.7270/Q2833W3C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Rattus norvegicus (rat)) | BDBM194802 (US9206167, 23 | USRE48059, Compound of Example 23) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.700 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Otsuka Pharmaceutical Co., Ltd. US Patent | Assay Description Dopamine D2: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-raclopride (final concentration 1 to 2 nM)... | US Patent USRE48059 (2020) BindingDB Entry DOI: 10.7270/Q2833W3C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Rattus norvegicus (rat)) | BDBM194808 (US10501452, Compound B | US9206167, 30 | USRE48059...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | US Patent | 0.700 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Otsuka Pharmaceutical Co., Ltd. US Patent | Assay Description Dopamine D2: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-raclopride (final concentration 1 to 2 nM)... | US Patent USRE48059 (2020) BindingDB Entry DOI: 10.7270/Q2833W3C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Rattus norvegicus (rat)) | BDBM194795 (US9206167, 16 | USRE48059, Compound of Example 16) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.700 | -52.3 | n/a | n/a | n/a | n/a | n/a | 7.4 | 25 |
OTSUKA PHARMACEUTICAL CO., LTD. US Patent | Assay Description The assay was performed according to the method by Kohler et al. (Kohler C, Hall H, Ogren S O and Gawell L, Specific in vitro and in vivo binding of ... | US Patent US9206167 (2015) BindingDB Entry DOI: 10.7270/Q2XD10GS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Rattus norvegicus (rat)) | BDBM194795 (US9206167, 16 | USRE48059, Compound of Example 16) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.700 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Otsuka Pharmaceutical Co., Ltd. US Patent | Assay Description Dopamine D2: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-raclopride (final concentration 1 to 2 nM)... | US Patent USRE48059 (2020) BindingDB Entry DOI: 10.7270/Q2833W3C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Rattus norvegicus (rat)) | BDBM194808 (US10501452, Compound B | US9206167, 30 | USRE48059...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | US Patent | 0.700 | -52.3 | n/a | n/a | n/a | n/a | n/a | 7.4 | 25 |
OTSUKA PHARMACEUTICAL CO., LTD. US Patent | Assay Description The assay was performed according to the method by Kohler et al. (Kohler C, Hall H, Ogren S O and Gawell L, Specific in vitro and in vivo binding of ... | US Patent US9206167 (2015) BindingDB Entry DOI: 10.7270/Q2XD10GS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Rattus norvegicus (rat)) | BDBM194802 (US9206167, 23 | USRE48059, Compound of Example 23) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.700 | -52.3 | n/a | n/a | n/a | n/a | n/a | 7.4 | 25 |
OTSUKA PHARMACEUTICAL CO., LTD. US Patent | Assay Description The assay was performed according to the method by Kohler et al. (Kohler C, Hall H, Ogren S O and Gawell L, Specific in vitro and in vivo binding of ... | US Patent US9206167 (2015) BindingDB Entry DOI: 10.7270/Q2XD10GS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Rattus norvegicus (rat)) | BDBM194779 (US9206167, 190) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.800 | -51.9 | n/a | n/a | n/a | n/a | n/a | 7.4 | 25 |
OTSUKA PHARMACEUTICAL CO., LTD. US Patent | Assay Description The assay was performed according to the method by Kohler et al. (Kohler C, Hall H, Ogren S O and Gawell L, Specific in vitro and in vivo binding of ... | US Patent US9206167 (2015) BindingDB Entry DOI: 10.7270/Q2XD10GS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Rattus norvegicus (rat)) | BDBM448323 (USRE48059, Compound of Example 69) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.800 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Otsuka Pharmaceutical Co., Ltd. US Patent | Assay Description Dopamine D2: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-raclopride (final concentration 1 to 2 nM)... | US Patent USRE48059 (2020) BindingDB Entry DOI: 10.7270/Q2833W3C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Rattus norvegicus (rat)) | BDBM194785 (US9206167, 6 | USRE48059, Compound of Example 6) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.800 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Otsuka Pharmaceutical Co., Ltd. US Patent | Assay Description Dopamine D2: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-raclopride (final concentration 1 to 2 nM)... | US Patent USRE48059 (2020) BindingDB Entry DOI: 10.7270/Q2833W3C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Rattus norvegicus (rat)) | BDBM194785 (US9206167, 6 | USRE48059, Compound of Example 6) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.800 | -51.9 | n/a | n/a | n/a | n/a | n/a | 7.4 | 25 |
OTSUKA PHARMACEUTICAL CO., LTD. US Patent | Assay Description The assay was performed according to the method by Kohler et al. (Kohler C, Hall H, Ogren S O and Gawell L, Specific in vitro and in vivo binding of ... | US Patent US9206167 (2015) BindingDB Entry DOI: 10.7270/Q2XD10GS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Rattus norvegicus (rat)) | BDBM194760 (US9206167, 81) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.800 | -51.9 | n/a | n/a | n/a | n/a | n/a | 7.4 | 25 |
OTSUKA PHARMACEUTICAL CO., LTD. US Patent | Assay Description The assay was performed according to the method by Kohler et al. (Kohler C, Hall H, Ogren S O and Gawell L, Specific in vitro and in vivo binding of ... | US Patent US9206167 (2015) BindingDB Entry DOI: 10.7270/Q2XD10GS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Rattus norvegicus (rat)) | BDBM194756 (US9206167, 69) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.800 | -51.9 | n/a | n/a | n/a | n/a | n/a | 7.4 | 25 |
OTSUKA PHARMACEUTICAL CO., LTD. US Patent | Assay Description The assay was performed according to the method by Kohler et al. (Kohler C, Hall H, Ogren S O and Gawell L, Specific in vitro and in vivo binding of ... | US Patent US9206167 (2015) BindingDB Entry DOI: 10.7270/Q2XD10GS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Rattus norvegicus (rat)) | BDBM448327 (USRE48059, Compound of Example 81) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.800 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Otsuka Pharmaceutical Co., Ltd. US Patent | Assay Description Dopamine D2: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-raclopride (final concentration 1 to 2 nM)... | US Patent USRE48059 (2020) BindingDB Entry DOI: 10.7270/Q2833W3C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Rattus norvegicus (rat)) | BDBM448346 (USRE48059, Compound of Example 190) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.800 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Otsuka Pharmaceutical Co., Ltd. US Patent | Assay Description Dopamine D2: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-raclopride (final concentration 1 to 2 nM)... | US Patent USRE48059 (2020) BindingDB Entry DOI: 10.7270/Q2833W3C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histamine H3 receptor (Homo sapiens (Human)) | BDBM50296171 (1-{3-[4-((2S,3S)-8-Methoxy-3-methyl-4,4-dioxo-3,4-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute Curated by ChEMBL | Assay Description Displacement of [3H]R-alpha-methylistamine from human histamine H3 receptor by cell-based assay | Bioorg Med Chem Lett 19: 4232-6 (2009) Article DOI: 10.1016/j.bmcl.2009.05.101 BindingDB Entry DOI: 10.7270/Q20G3K69 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Rattus norvegicus (rat)) | BDBM194814 (US9206167, 36 | USRE48059, Compound of Example 36) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Otsuka Pharmaceutical Co., Ltd. US Patent | Assay Description Dopamine D2: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-raclopride (final concentration 1 to 2 nM)... | US Patent USRE48059 (2020) BindingDB Entry DOI: 10.7270/Q2833W3C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Rattus norvegicus (rat)) | BDBM194755 (US9206167, 68) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 1 | -51.4 | n/a | n/a | n/a | n/a | n/a | 7.4 | 25 |
OTSUKA PHARMACEUTICAL CO., LTD. US Patent | Assay Description The assay was performed according to the method by Kohler et al. (Kohler C, Hall H, Ogren S O and Gawell L, Specific in vitro and in vivo binding of ... | US Patent US9206167 (2015) BindingDB Entry DOI: 10.7270/Q2XD10GS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 2A (Rattus norvegicus (rat)) | BDBM194800 (US9206167, 21 | USRE48059, Compound of Example 21) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Otsuka Pharmaceutical Co., Ltd. US Patent | Assay Description 5-HT2A: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-Ketanserin (final concentration 1 to 3 nM), 20 ... | US Patent USRE48059 (2020) BindingDB Entry DOI: 10.7270/Q2833W3C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Rattus norvegicus (rat)) | BDBM448322 (USRE48059, Compound of Example 68) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Otsuka Pharmaceutical Co., Ltd. US Patent | Assay Description Dopamine D2: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-raclopride (final concentration 1 to 2 nM)... | US Patent USRE48059 (2020) BindingDB Entry DOI: 10.7270/Q2833W3C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Rattus norvegicus (rat)) | BDBM194814 (US9206167, 36 | USRE48059, Compound of Example 36) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 1 | -51.4 | n/a | n/a | n/a | n/a | n/a | 7.4 | 25 |
OTSUKA PHARMACEUTICAL CO., LTD. US Patent | Assay Description The assay was performed according to the method by Kohler et al. (Kohler C, Hall H, Ogren S O and Gawell L, Specific in vitro and in vivo binding of ... | US Patent US9206167 (2015) BindingDB Entry DOI: 10.7270/Q2XD10GS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 2A (Rattus norvegicus (rat)) | BDBM194800 (US9206167, 21 | USRE48059, Compound of Example 21) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 1 | -53.4 | n/a | n/a | n/a | n/a | n/a | 7.4 | 37 |
OTSUKA PHARMACEUTICAL CO., LTD. US Patent | Assay Description The assay was performed according to the method by Leysen J E et al. (Leysen J E, Niemegeers C J E, Van Nueten J M and Laduron P M. [3H] Ketanserin (... | US Patent US9206167 (2015) BindingDB Entry DOI: 10.7270/Q2XD10GS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Rattus norvegicus (rat)) | BDBM194811 (US9206167, 33 | USRE48059, Compound of Example 33) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Otsuka Pharmaceutical Co., Ltd. US Patent | Assay Description Dopamine D2: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-raclopride (final concentration 1 to 2 nM)... | US Patent USRE48059 (2020) BindingDB Entry DOI: 10.7270/Q2833W3C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Rattus norvegicus (rat)) | BDBM194811 (US9206167, 33 | USRE48059, Compound of Example 33) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 1.10 | -51.1 | n/a | n/a | n/a | n/a | n/a | 7.4 | 25 |
OTSUKA PHARMACEUTICAL CO., LTD. US Patent | Assay Description The assay was performed according to the method by Kohler et al. (Kohler C, Hall H, Ogren S O and Gawell L, Specific in vitro and in vivo binding of ... | US Patent US9206167 (2015) BindingDB Entry DOI: 10.7270/Q2XD10GS | |||||||||||
More data for this Ligand-Target Pair |
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