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Compile Data Set for Download or QSAR

Found 81 hits with Last Name = 'esvan' and Initial = 'yj'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Serine/threonine-protein kinase haspin


(Homo sapiens (Human))		BDBM50587785
PNG
(CHEMBL5178368)
Show SMILES CCCNc1ccc2ncc(-c3ccc4[nH]ncc4c3)n2n1
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TBA



Citation and Details

Article DOI: 10.1016/j.ejmech.2022.114369
BindingDB Entry DOI: 10.7270/Q2HQ440P
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase haspin


(Homo sapiens (Human))		BDBM50605473
PNG
(CHEMBL5186093)
Show SMILES Nc1ccc2cc3cnccc3c([N+]([O-])=O)c2n1
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Citation and Details

Article DOI: 10.1016/j.ejmech.2022.114369
BindingDB Entry DOI: 10.7270/Q2HQ440P
More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK1


(Mus musculus)		BDBM50587785
PNG
(CHEMBL5178368)
Show SMILES CCCNc1ccc2ncc(-c3ccc4[nH]ncc4c3)n2n1
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Citation and Details

Article DOI: 10.1016/j.ejmech.2022.114369
BindingDB Entry DOI: 10.7270/Q2HQ440P
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase haspin


(Homo sapiens (Human))		BDBM50605464
PNG
(CHEMBL5188318)
Show SMILES CSc1ncc2cc3cnccc3c(N)c2n1
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Citation and Details

Article DOI: 10.1016/j.ejmech.2022.114369
BindingDB Entry DOI: 10.7270/Q2HQ440P
More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A


(RAT)		BDBM50587785
PNG
(CHEMBL5178368)
Show SMILES CCCNc1ccc2ncc(-c3ccc4[nH]ncc4c3)n2n1
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Citation and Details

Article DOI: 10.1016/j.ejmech.2022.114369
BindingDB Entry DOI: 10.7270/Q2HQ440P
More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK1


(Mus musculus)		BDBM50148458
PNG
(CHEMBL4778413)
Show SMILES CNc1ncc2cc3cnccc3c([N+]([O-])=O)c2n1
Show InChI InChI=1S/C18H18N2O4S/c1-19-17(21)15-8-11-16(25-15)12(9-20(2)18(11)22)10-5-6-13(23-3)14(7-10)24-4/h5-9H,1-4H3,(H,19,21)
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Assay Description
Inhibition of human plasmin using pyroGlu-Phe-Lys-pNA.HCl

Citation and Details

Article DOI: 10.1016/j.ejmech.2019.01.052
BindingDB Entry DOI: 10.7270/Q2BZ69NW
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Dual specificity protein kinase CLK1


(Mus musculus)		BDBM50605473
PNG
(CHEMBL5186093)
Show SMILES Nc1ccc2cc3cnccc3c([N+]([O-])=O)c2n1
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Citation and Details

Article DOI: 10.1016/j.ejmech.2022.114369
BindingDB Entry DOI: 10.7270/Q2HQ440P
More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A


(RAT)		BDBM50249773
PNG
(CHEMBL4763099)
Show SMILES CN1CCN(CCCNc2ncc3cc4cnccc4c(N)c3n2)CC1
Show InChI InChI=1S/C13H16N2O3S/c1-9(2)19(17,18)14-11-5-6-12-10(8-11)4-7-13(16)15(12)3/h4-9,14H,1-3H3
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Assay Description
Inhibition of BRD9 (unknown origin) incubated in dark for 30 mins by TR-FRET assay

Citation and Details

Article DOI: 10.1016/j.ejmech.2019.01.052
BindingDB Entry DOI: 10.7270/Q2BZ69NW
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))		BDBM50178616
PNG
(CHEMBL3814423)
Show SMILES c1n[nH]c2c1c1c3ccccc3[nH]c1c1[nH]c3ccccc3c21
Show InChI InChI=1S/C19H12N4/c1-3-7-13-10(5-1)15-12-9-20-23-17(12)16-11-6-2-4-8-14(11)22-19(16)18(15)21-13/h1-9,21-22H,(H,20,23)
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Universit£ Clermont Auvergne

Curated by ChEMBL


Assay Description
Inhibition of human full length (His)6-tagged Pim-3 expressed in insect Sf21 cells using RSRHSSYPAGT as substrate measured for 30 mins by [gamma-33P]...

Bioorg Med Chem 24: 3116-24 (2016)


Article DOI: 10.1016/j.bmc.2016.05.032
BindingDB Entry DOI: 10.7270/Q2ZG6V50
More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A


(RAT)		BDBM50249769
PNG
(CHEMBL4748345)
Show SMILES Nc1c2ccncc2cc2cnc(NCCCN3CCOCC3)nc12
Show InChI InChI=1S/C16H14N2O3S/c1-18-15-9-8-14(11-12(15)7-10-16(18)19)22(20,21)17-13-5-3-2-4-6-13/h2-11,17H,1H3
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TBA

Assay Description
Inhibition of BRD9 (unknown origin) incubated in dark for 30 mins by TR-FRET assay

Citation and Details

Article DOI: 10.1016/j.ejmech.2019.01.052
BindingDB Entry DOI: 10.7270/Q2BZ69NW
More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A


(RAT)		BDBM50185005
PNG
(CHEMBL3823483)
Show SMILES Nc1ncc2cc3cnccc3c(N)c2n1
Show InChI InChI=1S/C11H9N5/c12-9-8-1-2-14-4-6(8)3-7-5-15-11(13)16-10(7)9/h1-5H,12H2,(H2,13,15,16)
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Universit£ Clermont Auvergne

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged rat recombinant DYRK1A expressed in Escherichia coli using myelin basic protein as substrate incubated for 30 mins in presen...

Eur J Med Chem 118: 170-7 (2016)


Article DOI: 10.1016/j.ejmech.2016.04.004
BindingDB Entry DOI: 10.7270/Q29888XM
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM50587785
PNG
(CHEMBL5178368)
Show SMILES CCCNc1ccc2ncc(-c3ccc4[nH]ncc4c3)n2n1
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Citation and Details

Article DOI: 10.1016/j.ejmech.2022.114369
BindingDB Entry DOI: 10.7270/Q2HQ440P
More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK1


(Mus musculus)		BDBM50605464
PNG
(CHEMBL5188318)
Show SMILES CSc1ncc2cc3cnccc3c(N)c2n1
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Citation and Details

Article DOI: 10.1016/j.ejmech.2022.114369
BindingDB Entry DOI: 10.7270/Q2HQ440P
More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK1


(Homo sapiens (Human))		BDBM50185005
PNG
(CHEMBL3823483)
Show SMILES Nc1ncc2cc3cnccc3c(N)c2n1
Show InChI InChI=1S/C11H9N5/c12-9-8-1-2-14-4-6(8)3-7-5-15-11(13)16-10(7)9/h1-5H,12H2,(H2,13,15,16)
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Universit£ Clermont Auvergne

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged human recombinant CLK1 expressed in Escherichia coli using RS peptide as substrate

Eur J Med Chem 118: 170-7 (2016)


Article DOI: 10.1016/j.ejmech.2016.04.004
BindingDB Entry DOI: 10.7270/Q29888XM
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Cyclin-dependent kinase 5 activator 1


(Homo sapiens (Human))		BDBM50587785
PNG
(CHEMBL5178368)
Show SMILES CCCNc1ccc2ncc(-c3ccc4[nH]ncc4c3)n2n1
PDB
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Citation and Details

Article DOI: 10.1016/j.ejmech.2022.114369
BindingDB Entry DOI: 10.7270/Q2HQ440P
More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A


(RAT)		BDBM50605464
PNG
(CHEMBL5188318)
Show SMILES CSc1ncc2cc3cnccc3c(N)c2n1
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Citation and Details

Article DOI: 10.1016/j.ejmech.2022.114369
BindingDB Entry DOI: 10.7270/Q2HQ440P
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase haspin


(Homo sapiens (Human))		BDBM50605471
PNG
(CHEMBL5181620)
Show SMILES COc1ncc2cc3cnccc3c([N+]([O-])=O)c2n1
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Citation and Details

Article DOI: 10.1016/j.ejmech.2022.114369
BindingDB Entry DOI: 10.7270/Q2HQ440P
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))		BDBM50587785
PNG
(CHEMBL5178368)
Show SMILES CCCNc1ccc2ncc(-c3ccc4[nH]ncc4c3)n2n1
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Citation and Details

Article DOI: 10.1016/j.ejmech.2022.114369
BindingDB Entry DOI: 10.7270/Q2HQ440P
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase haspin


(Homo sapiens (Human))		BDBM50605467
PNG
(CHEMBL5177344)
Show SMILES CC(C)Sc1ncc2cc3cnccc3c(N)c2n1
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Citation and Details

Article DOI: 10.1016/j.ejmech.2022.114369
BindingDB Entry DOI: 10.7270/Q2HQ440P
More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK1


(Mus musculus)		BDBM50148388
PNG
(CHEMBL4784564)
Show SMILES CN(C)CCNc1ncc2cc3cnccc3c([N+]([O-])=O)c2n1
Show InChI InChI=1S/C18H19N3O3S/c1-20-17(19)15-8-11-16(25-15)12(9-21(2)18(11)22)10-5-6-13(23-3)14(7-10)24-4/h5-9H,1-4H3,(H2,19,20)
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TBA

Assay Description
Inhibition of human plasmin using pyroGlu-Phe-Lys-pNA.HCl

Citation and Details

Article DOI: 10.1016/j.ejmech.2019.01.052
BindingDB Entry DOI: 10.7270/Q2BZ69NW
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase haspin


(Homo sapiens (Human))		BDBM50605466
PNG
(CHEMBL5194011)
Show SMILES CCCSc1ncc2cc3cnccc3c(N)c2n1
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Citation and Details

Article DOI: 10.1016/j.ejmech.2022.114369
BindingDB Entry DOI: 10.7270/Q2HQ440P
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase haspin


(Homo sapiens (Human))		BDBM50605471
PNG
(CHEMBL5181620)
Show SMILES COc1ncc2cc3cnccc3c([N+]([O-])=O)c2n1
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Citation and Details

Article DOI: 10.1016/j.ejmech.2022.114369
BindingDB Entry DOI: 10.7270/Q2HQ440P
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase haspin


(Homo sapiens (Human))		BDBM50605468
PNG
(CHEMBL5186471)
Show SMILES CCCCSc1ncc2cc3cnccc3c(N)c2n1
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Citation and Details

Article DOI: 10.1016/j.ejmech.2022.114369
BindingDB Entry DOI: 10.7270/Q2HQ440P
More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK1


(Homo sapiens (Human))		BDBM50185004
PNG
(CHEMBL3823532)
Show SMILES Nc1ncc2cc3cnccc3c([N+]([O-])=O)c2n1
Show InChI InChI=1S/C11H7N5O2/c12-11-14-5-7-3-6-4-13-2-1-8(6)10(16(17)18)9(7)15-11/h1-5H,(H2,12,14,15)
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Universit£ Clermont Auvergne

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged human recombinant CLK1 expressed in Escherichia coli using RS peptide as substrate

Eur J Med Chem 118: 170-7 (2016)


Article DOI: 10.1016/j.ejmech.2016.04.004
BindingDB Entry DOI: 10.7270/Q29888XM
More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK1


(Mus musculus)		BDBM50605467
PNG
(CHEMBL5177344)
Show SMILES CC(C)Sc1ncc2cc3cnccc3c(N)c2n1
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Citation and Details

Article DOI: 10.1016/j.ejmech.2022.114369
BindingDB Entry DOI: 10.7270/Q2HQ440P
More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A


(RAT)		BDBM50249763
PNG
(CHEMBL4794934)
Show SMILES CCN(CC)CCCNc1ncc2cc3cnccc3c(N)c2n1
Show InChI InChI=1S/C17H13N3O3S/c1-20-16-8-7-15(10-13(16)4-9-17(20)21)24(22,23)19-14-5-2-12(11-18)3-6-14/h2-10,19H,1H3
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Assay Description
Binding affinity to partial length human BRD9 by BROMOscan assay

Citation and Details

Article DOI: 10.1016/j.ejmech.2019.01.052
BindingDB Entry DOI: 10.7270/Q2BZ69NW
More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK1


(Mus musculus)		BDBM50509920
PNG
(CHEMBL4558273)
Show SMILES CN(C)CNc1ncc2cc3cnccc3c([N+]([O-])=O)c2n1
Show InChI InChI=1S/C14H14N6O2/c1-19(2)8-17-14-16-7-10-5-9-6-15-4-3-11(9)13(20(21)22)12(10)18-14/h3-7H,8H2,1-2H3,(H,16,17,18)
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Universit£ Clermont Auvergne

Curated by ChEMBL


Assay Description
Inhibition of recombinant mouse CLK1 expressed in bacteria using GRSRSRSRSRSR as substrate in presence of [gamma33P]ATP

Bioorg Med Chem 27: 2083-2089 (2019)


Article DOI: 10.1016/j.bmc.2019.04.005
BindingDB Entry DOI: 10.7270/Q25H7KKN
More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A


(RAT)		BDBM50605473
PNG
(CHEMBL5186093)
Show SMILES Nc1ccc2cc3cnccc3c([N+]([O-])=O)c2n1
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Citation and Details

Article DOI: 10.1016/j.ejmech.2022.114369
BindingDB Entry DOI: 10.7270/Q2HQ440P
More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK1


(Mus musculus)		BDBM50605466
PNG
(CHEMBL5194011)
Show SMILES CCCSc1ncc2cc3cnccc3c(N)c2n1
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Citation and Details

Article DOI: 10.1016/j.ejmech.2022.114369
BindingDB Entry DOI: 10.7270/Q2HQ440P
More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A


(RAT)		BDBM50249774
PNG
(CHEMBL4776402)
Show SMILES Nc1c2ccncc2cc2cnc(NCCCN3CCCC3)nc12
Show InChI InChI=1S/C12H14N2O3S/c1-3-18(16,17)13-10-5-6-11-9(8-10)4-7-12(15)14(11)2/h4-8,13H,3H2,1-2H3
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TBA

Assay Description
Inhibition of BRD9 (unknown origin) incubated in dark for 30 mins by TR-FRET assay

Citation and Details

Article DOI: 10.1016/j.ejmech.2019.01.052
BindingDB Entry DOI: 10.7270/Q2BZ69NW
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase haspin


(Homo sapiens (Human))		BDBM50605458
PNG
(CHEMBL5196946)
Show SMILES CCSc1ncc2cc3cnccc3c([N+]([O-])=O)c2n1
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TBA



Citation and Details

Article DOI: 10.1016/j.ejmech.2022.114369
BindingDB Entry DOI: 10.7270/Q2HQ440P
More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK1


(Mus musculus)		BDBM50605468
PNG
(CHEMBL5186471)
Show SMILES CCCCSc1ncc2cc3cnccc3c(N)c2n1
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Citation and Details

Article DOI: 10.1016/j.ejmech.2022.114369
BindingDB Entry DOI: 10.7270/Q2HQ440P
More data for this
Ligand-Target Pair
Casein kinase I isoform epsilon


(Homo sapiens (Human))		BDBM50587785
PNG
(CHEMBL5178368)
Show SMILES CCCNc1ccc2ncc(-c3ccc4[nH]ncc4c3)n2n1
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Citation and Details

Article DOI: 10.1016/j.ejmech.2022.114369
BindingDB Entry DOI: 10.7270/Q2HQ440P
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase haspin


(Homo sapiens (Human))		BDBM50605460
PNG
(CHEMBL5208358)
Show SMILES CC(C)Sc1ncc2cc3cnccc3c([N+]([O-])=O)c2n1
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Citation and Details

Article DOI: 10.1016/j.ejmech.2022.114369
BindingDB Entry DOI: 10.7270/Q2HQ440P
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK3


(Homo sapiens (Human))		BDBM50605471
PNG
(CHEMBL5181620)
Show SMILES COc1ncc2cc3cnccc3c([N+]([O-])=O)c2n1
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Citation and Details

Article DOI: 10.1016/j.ejmech.2022.114369
BindingDB Entry DOI: 10.7270/Q2HQ440P
More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK1


(Mus musculus)		BDBM50249773
PNG
(CHEMBL4763099)
Show SMILES CN1CCN(CCCNc2ncc3cc4cnccc4c(N)c3n2)CC1
Show InChI InChI=1S/C13H16N2O3S/c1-9(2)19(17,18)14-11-5-6-12-10(8-11)4-7-13(16)15(12)3/h4-9,14H,1-3H3
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TBA

Assay Description
Inhibition of BRD9 (unknown origin) incubated in dark for 30 mins by TR-FRET assay

Citation and Details

Article DOI: 10.1016/j.ejmech.2019.01.052
BindingDB Entry DOI: 10.7270/Q2BZ69NW
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase haspin


(Homo sapiens (Human))		BDBM50605457
PNG
(CHEMBL5183366)
Show SMILES CSc1ncc2cc3cnccc3c([N+]([O-])=O)c2n1
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Citation and Details

Article DOI: 10.1016/j.ejmech.2022.114369
BindingDB Entry DOI: 10.7270/Q2HQ440P
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))		BDBM50587785
PNG
(CHEMBL5178368)
Show SMILES CCCNc1ccc2ncc(-c3ccc4[nH]ncc4c3)n2n1
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Citation and Details

Article DOI: 10.1016/j.ejmech.2022.114369
BindingDB Entry DOI: 10.7270/Q2HQ440P
More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK1


(Mus musculus)		BDBM50148455
PNG
(CHEMBL4791275)
Show SMILES [O-][N+](=O)c1c2ccncc2cc2cnc(NCCCN3CCOCC3)nc12
Show InChI InChI=1S/C23H24F3N3O3S2/c1-13(2)29-12-18(14-4-3-5-15(10-14)23(24,25)26)20-17(22(29)30)11-19(33-20)21(27)28-16-6-8-34(31,32)9-7-16/h3-5,10-13,16H,6-9H2,1-2H3,(H2,27,28)
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Assay Description
Inhibition of human urine urokinase using L-PyroGlu-Gly-Arg-pNA.HCl substrate at 5 uM

Citation and Details

Article DOI: 10.1016/j.ejmech.2019.01.052
BindingDB Entry DOI: 10.7270/Q2BZ69NW
More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A


(RAT)		BDBM50148459
PNG
(CHEMBL4755373)
Show SMILES CN1CCN(CCNc2ncc3cc4cnccc4c(N)c3n2)CC1
Show InChI InChI=1S/C22H24N2O6S2/c1-24-12-16(13-4-5-17(29-2)18(10-13)30-3)20-15(22(24)26)11-19(31-20)21(25)23-14-6-8-32(27,28)9-7-14/h4-5,10-12,14H,6-9H2,1-3H3,(H,23,25)
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TBA

Assay Description
Inhibition of BRD9 (unknown origin) incubated in dark for 30 mins by TR-FRET assay

Citation and Details

Article DOI: 10.1016/j.ejmech.2019.01.052
BindingDB Entry DOI: 10.7270/Q2BZ69NW
More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A


(RAT)		BDBM50249762
PNG
(CHEMBL4759771)
Show SMILES CN(C)CCCNc1ncc2cc3cnccc3c(N)c2n1
Show InChI InChI=1S/C13H14N2O3S/c1-15-12-6-3-10(8-9(12)2-7-13(15)16)14-19(17,18)11-4-5-11/h2-3,6-8,11,14H,4-5H2,1H3
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Assay Description
Inhibition of BRD9 (unknown origin) incubated in dark for 30 mins by TR-FRET assay

Citation and Details

Article DOI: 10.1016/j.ejmech.2019.01.052
BindingDB Entry DOI: 10.7270/Q2BZ69NW
More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK1


(Mus musculus)		BDBM50249762
PNG
(CHEMBL4759771)
Show SMILES CN(C)CCCNc1ncc2cc3cnccc3c(N)c2n1
Show InChI InChI=1S/C13H14N2O3S/c1-15-12-6-3-10(8-9(12)2-7-13(15)16)14-19(17,18)11-4-5-11/h2-3,6-8,11,14H,4-5H2,1H3
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Assay Description
Inhibition of BRD9 in human HUT78 cells incubated for 45 mins by chemoproteomic competition binding assay

Citation and Details

Article DOI: 10.1016/j.ejmech.2019.01.052
BindingDB Entry DOI: 10.7270/Q2BZ69NW
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase haspin


(Homo sapiens (Human))		BDBM50605465
PNG
(CHEMBL5202187)
Show SMILES CCSc1ncc2cc3cnccc3c(N)c2n1
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Citation and Details

Article DOI: 10.1016/j.ejmech.2022.114369
BindingDB Entry DOI: 10.7270/Q2HQ440P
More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK1


(Mus musculus)		BDBM50148457
PNG
(CHEMBL4780720)
Show SMILES [O-][N+](=O)c1c2ccncc2cc2cnc(NCCCN3CCCCC3)nc12
Show InChI InChI=1S/C20H21N3O3S2/c1-23-12-16(13-5-3-2-4-6-13)18-15(20(23)24)11-17(27-18)19(21)22-14-7-9-28(25,26)10-8-14/h2-6,11-12,14H,7-10H2,1H3,(H2,21,22)
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Assay Description
Inhibition of human urine urokinase using L-PyroGlu-Gly-Arg-pNA.HCl substrate at 5 uM

Citation and Details

Article DOI: 10.1016/j.ejmech.2019.01.052
BindingDB Entry DOI: 10.7270/Q2BZ69NW
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK2


(Homo sapiens (Human))		BDBM50605471
PNG
(CHEMBL5181620)
Show SMILES COc1ncc2cc3cnccc3c([N+]([O-])=O)c2n1
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Citation and Details

Article DOI: 10.1016/j.ejmech.2022.114369
BindingDB Entry DOI: 10.7270/Q2HQ440P
More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A


(RAT)		BDBM50605468
PNG
(CHEMBL5186471)
Show SMILES CCCCSc1ncc2cc3cnccc3c(N)c2n1
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Citation and Details

Article DOI: 10.1016/j.ejmech.2022.114369
BindingDB Entry DOI: 10.7270/Q2HQ440P
More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK1


(Mus musculus)		BDBM50148456
PNG
(CHEMBL4785650)
Show SMILES CN1CCN(CCCNc2ncc3cc4cnccc4c([N+]([O-])=O)c3n2)CC1
Show InChI InChI=1S/C22H25N3O5S2/c1-25-12-16(13-4-5-17(29-2)18(10-13)30-3)20-15(22(25)26)11-19(31-20)21(23)24-14-6-8-32(27,28)9-7-14/h4-5,10-12,14H,6-9H2,1-3H3,(H2,23,24)
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Assay Description
Inhibition of human urine urokinase using L-PyroGlu-Gly-Arg-pNA.HCl substrate at 5 uM

Citation and Details

Article DOI: 10.1016/j.ejmech.2019.01.052
BindingDB Entry DOI: 10.7270/Q2BZ69NW
More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK1


(Mus musculus)		BDBM50605458
PNG
(CHEMBL5196946)
Show SMILES CCSc1ncc2cc3cnccc3c([N+]([O-])=O)c2n1
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Citation and Details

Article DOI: 10.1016/j.ejmech.2022.114369
BindingDB Entry DOI: 10.7270/Q2HQ440P
More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A


(RAT)		BDBM50605466
PNG
(CHEMBL5194011)
Show SMILES CCCSc1ncc2cc3cnccc3c(N)c2n1
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Citation and Details

Article DOI: 10.1016/j.ejmech.2022.114369
BindingDB Entry DOI: 10.7270/Q2HQ440P
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM50178616
PNG
(CHEMBL3814423)
Show SMILES c1n[nH]c2c1c1c3ccccc3[nH]c1c1[nH]c3ccccc3c21
Show InChI InChI=1S/C19H12N4/c1-3-7-13-10(5-1)15-12-9-20-23-17(12)16-11-6-2-4-8-14(11)22-19(16)18(15)21-13/h1-9,21-22H,(H,20,23)
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Universit£ Clermont Auvergne

Curated by ChEMBL


Assay Description
Inhibition of human full length (His)6-tagged Pim-1 expressed in insect Sf21 cells using RSRHSSYPAGT as substrate measured for 30 mins by [gamma-33P]...

Bioorg Med Chem 24: 3116-24 (2016)


Article DOI: 10.1016/j.bmc.2016.05.032
BindingDB Entry DOI: 10.7270/Q2ZG6V50
More data for this
Ligand-Target Pair
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