Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sterol 14-alpha demethylase (Trypanosoma cruzi) | BDBM25810 (2-phenyl-N-(pyridin-4-yl)butanamide | 2-phenyl-N-p...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | n/a | 440 | n/a | n/a | n/a | 7.4 | 24 |
Vanderbilt University | Assay Description As a cysteine-coordinated hemoprotein, sterol 14-alpha-demethylase responds spectrally to any perturbations in the area surrounding the heme iron. Th... | J Med Chem 52: 2846-53 (2009) Article DOI: 10.1021/jm801643b BindingDB Entry DOI: 10.7270/Q2MP51MG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sterol 14-alpha demethylase (Trypanosoma cruzi) | BDBM29341 (ChemDiv 5556-0480, 7) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | 750 | n/a | n/a | n/a | 7.4 | 24 |
Vanderbilt University | Assay Description As a cysteine-coordinated hemoprotein, sterol 14-alpha-demethylase responds spectrally to any perturbations in the area surrounding the heme iron. Th... | J Med Chem 52: 2846-53 (2009) Article DOI: 10.1021/jm801643b BindingDB Entry DOI: 10.7270/Q2MP51MG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sterol 14-alpha demethylase (Trypanosoma cruzi) | BDBM29342 (ChemDiv C155-0123, 9) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | n/a | 240 | n/a | n/a | n/a | 7.4 | 24 |
Vanderbilt University | Assay Description As a cysteine-coordinated hemoprotein, sterol 14-alpha-demethylase responds spectrally to any perturbations in the area surrounding the heme iron. Th... | J Med Chem 52: 2846-53 (2009) Article DOI: 10.1021/jm801643b BindingDB Entry DOI: 10.7270/Q2MP51MG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sterol 14-alpha demethylase (Trypanosoma cruzi) | BDBM22962 (2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | 290 | n/a | n/a | n/a | 7.4 | 24 |
Vanderbilt University | Assay Description As a cysteine-coordinated hemoprotein, sterol 14-alpha-demethylase responds spectrally to any perturbations in the area surrounding the heme iron. Th... | J Med Chem 52: 2846-53 (2009) Article DOI: 10.1021/jm801643b BindingDB Entry DOI: 10.7270/Q2MP51MG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sterol 14-alpha demethylase (Trypanosoma cruzi) | BDBM29343 (Indomethacin-amide derivative, 13) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | 7.60E+3 | n/a | n/a | n/a | 7.4 | 24 |
Vanderbilt University | Assay Description As a cysteine-coordinated hemoprotein, sterol 14-alpha-demethylase responds spectrally to any perturbations in the area surrounding the heme iron. Th... | J Med Chem 52: 2846-53 (2009) Article DOI: 10.1021/jm801643b BindingDB Entry DOI: 10.7270/Q2MP51MG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sterol 14-alpha demethylase (Trypanosoma cruzi) | BDBM29344 (Indomethacin-amide derivative, 14) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | 540 | n/a | n/a | n/a | 7.4 | 24 |
Vanderbilt University | Assay Description As a cysteine-coordinated hemoprotein, sterol 14-alpha-demethylase responds spectrally to any perturbations in the area surrounding the heme iron. Th... | J Med Chem 52: 2846-53 (2009) Article DOI: 10.1021/jm801643b BindingDB Entry DOI: 10.7270/Q2MP51MG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sterol 14-alpha demethylase (Trypanosoma cruzi) | BDBM29351 (Indomethacin-amide derivative, 22) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | 150 | n/a | n/a | n/a | 7.4 | 24 |
Vanderbilt University | Assay Description As a cysteine-coordinated hemoprotein, sterol 14-alpha-demethylase responds spectrally to any perturbations in the area surrounding the heme iron. Th... | J Med Chem 52: 2846-53 (2009) Article DOI: 10.1021/jm801643b BindingDB Entry DOI: 10.7270/Q2MP51MG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sterol 14-alpha demethylase (Trypanosoma cruzi) | BDBM29346 (Indomethacin-amide derivative, 16) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | 3.30E+3 | n/a | n/a | n/a | 7.4 | 24 |
Vanderbilt University | Assay Description As a cysteine-coordinated hemoprotein, sterol 14-alpha-demethylase responds spectrally to any perturbations in the area surrounding the heme iron. Th... | J Med Chem 52: 2846-53 (2009) Article DOI: 10.1021/jm801643b BindingDB Entry DOI: 10.7270/Q2MP51MG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sterol 14-alpha demethylase (Trypanosoma cruzi) | BDBM29347 (Indomethacin-amide derivative, 19) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | 560 | n/a | n/a | n/a | 7.4 | 24 |
Vanderbilt University | Assay Description As a cysteine-coordinated hemoprotein, sterol 14-alpha-demethylase responds spectrally to any perturbations in the area surrounding the heme iron. Th... | J Med Chem 52: 2846-53 (2009) Article DOI: 10.1021/jm801643b BindingDB Entry DOI: 10.7270/Q2MP51MG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sterol 14-alpha demethylase (Trypanosoma cruzi) | BDBM29348 (Indomethacin-amide derivative, 18) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | 260 | n/a | n/a | n/a | 7.4 | 24 |
Vanderbilt University | Assay Description As a cysteine-coordinated hemoprotein, sterol 14-alpha-demethylase responds spectrally to any perturbations in the area surrounding the heme iron. Th... | J Med Chem 52: 2846-53 (2009) Article DOI: 10.1021/jm801643b BindingDB Entry DOI: 10.7270/Q2MP51MG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sterol 14-alpha demethylase (Trypanosoma cruzi) | BDBM29349 (Indomethacin-amide derivative, 20) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | 2.31E+3 | n/a | n/a | n/a | 7.4 | 24 |
Vanderbilt University | Assay Description As a cysteine-coordinated hemoprotein, sterol 14-alpha-demethylase responds spectrally to any perturbations in the area surrounding the heme iron. Th... | J Med Chem 52: 2846-53 (2009) Article DOI: 10.1021/jm801643b BindingDB Entry DOI: 10.7270/Q2MP51MG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sterol 14-alpha demethylase (Trypanosoma cruzi) | BDBM29350 (Indomethacin-amide derivative, 21) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | 360 | n/a | n/a | n/a | 7.4 | 24 |
Vanderbilt University | Assay Description As a cysteine-coordinated hemoprotein, sterol 14-alpha-demethylase responds spectrally to any perturbations in the area surrounding the heme iron. Th... | J Med Chem 52: 2846-53 (2009) Article DOI: 10.1021/jm801643b BindingDB Entry DOI: 10.7270/Q2MP51MG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sterol 14-alpha demethylase (Trypanosoma cruzi) | BDBM29345 (Indomethacin-amide derivative, 15) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | 370 | n/a | n/a | n/a | 7.4 | 24 |
Vanderbilt University | Assay Description As a cysteine-coordinated hemoprotein, sterol 14-alpha-demethylase responds spectrally to any perturbations in the area surrounding the heme iron. Th... | J Med Chem 52: 2846-53 (2009) Article DOI: 10.1021/jm801643b BindingDB Entry DOI: 10.7270/Q2MP51MG | |||||||||||
More data for this Ligand-Target Pair |