Compile Data Set for Download or QSAR

Found 126 hits with Last Name = 'ekwuru' and Initial = 'ct'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human))	BDBM278409 ((2S)-2-[3-(Difluoromethoxy)phenyl]-2-methoxy-N-[5-...) Show SMILES CO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1cccc(OC(F)F)c1 |r| Show InChI InChI=1S/C20H21F2N7O3S/c1-31-16(12-4-2-5-14(10-12)32-18(21)22)17(30)25-20-28-27-19(33-20)24-13-7-9-29(11-13)15-6-3-8-23-26-15/h2-6,8,10,13,16,18H,7,9,11H2,1H3,(H,24,27)(H,25,28,30)/t13-,16+/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	14.8	n/a	n/a	n/a	n/a	7.8	n/a
AstraZeneca AB; Cancer Research Technology Limited US Patent					Assay Description A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...				US Patent US10040788 (2018) BindingDB Entry DOI: 10.7270/Q2Z321PG
					More data for this Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human))	BDBM278409 ((2S)-2-[3-(Difluoromethoxy)phenyl]-2-methoxy-N-[5-...) Show SMILES CO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1cccc(OC(F)F)c1 |r| Show InChI InChI=1S/C20H21F2N7O3S/c1-31-16(12-4-2-5-14(10-12)32-18(21)22)17(30)25-20-28-27-19(33-20)24-13-7-9-29(11-13)15-6-3-8-23-26-15/h2-6,8,10,13,16,18H,7,9,11H2,1H3,(H,24,27)(H,25,28,30)/t13-,16+/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	14.8	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company					Assay Description A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...				Bioorg Med Chem Lett 18: 1577-82 (2008) BindingDB Entry DOI: 10.7270/Q2MK6G78
					More data for this Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human))	BDBM278401 ((2R)-2-Methoxy-2-phenyl-N-[5-[[(3R)-1-pyridazin-3-...) Show SMILES CO[C@@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1ccccc1 |r| Show InChI InChI=1S/C19H21N7O2S/c1-28-16(13-6-3-2-4-7-13)17(27)22-19-25-24-18(29-19)21-14-9-11-26(12-14)15-8-5-10-20-23-15/h2-8,10,14,16H,9,11-12H2,1H3,(H,21,24)(H,22,25,27)/t14-,16-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	15.3	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company					Assay Description A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...				Bioorg Med Chem Lett 18: 1577-82 (2008) BindingDB Entry DOI: 10.7270/Q2MK6G78
					More data for this Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human))	BDBM278400 ((2S)-2-Methoxy-2-phenyl-N-[5-[[(3R)-1-pyridazin-3-...) Show SMILES CO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1ccccc1 |r| Show InChI InChI=1S/C19H21N7O2S/c1-28-16(13-6-3-2-4-7-13)17(27)22-19-25-24-18(29-19)21-14-9-11-26(12-14)15-8-5-10-20-23-15/h2-8,10,14,16H,9,11-12H2,1H3,(H,21,24)(H,22,25,27)/t14-,16+/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid PDB UniChem	PDB US Patent	n/a	n/a	15.3	n/a	n/a	n/a	n/a	7.8	n/a
AstraZeneca AB; Cancer Research Technology Limited US Patent					Assay Description A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...				US Patent US10040788 (2018) BindingDB Entry DOI: 10.7270/Q2Z321PG
					More data for this Ligand-Target Pair				3D Structure (crystal)
Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human))	BDBM278401 ((2R)-2-Methoxy-2-phenyl-N-[5-[[(3R)-1-pyridazin-3-...) Show SMILES CO[C@@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1ccccc1 |r| Show InChI InChI=1S/C19H21N7O2S/c1-28-16(13-6-3-2-4-7-13)17(27)22-19-25-24-18(29-19)21-14-9-11-26(12-14)15-8-5-10-20-23-15/h2-8,10,14,16H,9,11-12H2,1H3,(H,21,24)(H,22,25,27)/t14-,16-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	16.2	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company					Assay Description A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...				Bioorg Med Chem Lett 18: 1577-82 (2008) BindingDB Entry DOI: 10.7270/Q2MK6G78
					More data for this Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human))	BDBM278400 ((2S)-2-Methoxy-2-phenyl-N-[5-[[(3R)-1-pyridazin-3-...) Show SMILES CO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1ccccc1 |r| Show InChI InChI=1S/C19H21N7O2S/c1-28-16(13-6-3-2-4-7-13)17(27)22-19-25-24-18(29-19)21-14-9-11-26(12-14)15-8-5-10-20-23-15/h2-8,10,14,16H,9,11-12H2,1H3,(H,21,24)(H,22,25,27)/t14-,16+/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid PDB UniChem	PDB US Patent	n/a	n/a	16.2	n/a	n/a	n/a	n/a	7.8	n/a
AstraZeneca AB; Cancer Research Technology Limited US Patent					Assay Description A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...				US Patent US10040788 (2018) BindingDB Entry DOI: 10.7270/Q2Z321PG
					More data for this Ligand-Target Pair				3D Structure (crystal)
Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human))	BDBM278413 ((2S)-2-Methoxy-N-[5-[[(3R)-1-pyridazin-3-ylpyrroli...) Show SMILES CO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1cccc(OC(F)(F)F)c1 |r| Show InChI InChI=1S/C20H20F3N7O3S/c1-32-16(12-4-2-5-14(10-12)33-20(21,22)23)17(31)26-19-29-28-18(34-19)25-13-7-9-30(11-13)15-6-3-8-24-27-15/h2-6,8,10,13,16H,7,9,11H2,1H3,(H,25,28)(H,26,29,31)/t13-,16+/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	18.6	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company					Assay Description A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...				Bioorg Med Chem Lett 18: 1577-82 (2008) BindingDB Entry DOI: 10.7270/Q2MK6G78
					More data for this Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human))	BDBM278413 ((2S)-2-Methoxy-N-[5-[[(3R)-1-pyridazin-3-ylpyrroli...) Show SMILES CO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1cccc(OC(F)(F)F)c1 |r| Show InChI InChI=1S/C20H20F3N7O3S/c1-32-16(12-4-2-5-14(10-12)33-20(21,22)23)17(31)26-19-29-28-18(34-19)25-13-7-9-30(11-13)15-6-3-8-24-27-15/h2-6,8,10,13,16H,7,9,11H2,1H3,(H,25,28)(H,26,29,31)/t13-,16+/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	18.6	n/a	n/a	n/a	n/a	7.8	n/a
AstraZeneca AB; Cancer Research Technology Limited US Patent					Assay Description A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...				US Patent US10040788 (2018) BindingDB Entry DOI: 10.7270/Q2Z321PG
					More data for this Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human))	BDBM278450 (US10040788, Example 30(b)) Show SMILES CCO[C@H](C(=O)Nc1nnc(N[C@H]2CCN(C2)c2cccnn2)s1)c1cccc(OC)c1 |r| Show InChI InChI=1S/C21H25N7O3S/c1-3-31-18(14-6-4-7-16(12-14)30-2)19(29)24-21-27-26-20(32-21)23-15-9-11-28(13-15)17-8-5-10-22-25-17/h4-8,10,12,15,18H,3,9,11,13H2,1-2H3,(H,23,26)(H,24,27,29)/t15-,18-/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	21	n/a	n/a	n/a	n/a	7.8	n/a
AstraZeneca AB; Cancer Research Technology Limited US Patent					Assay Description A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...				US Patent US10040788 (2018) BindingDB Entry DOI: 10.7270/Q2Z321PG
					More data for this Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human))	BDBM387867 (US10294221, Example 30(b)) Show SMILES CCO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1cccc(OC)c1 |r| Show InChI InChI=1S/C21H25N7O3S/c1-3-31-18(14-6-4-7-16(12-14)30-2)19(29)24-21-27-26-20(32-21)23-15-9-11-28(13-15)17-8-5-10-22-25-17/h4-8,10,12,15,18H,3,9,11,13H2,1-2H3,(H,23,26)(H,24,27,29)/t15-,18+/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	21	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company					Assay Description A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...				Bioorg Med Chem Lett 18: 1577-82 (2008) BindingDB Entry DOI: 10.7270/Q2MK6G78
					More data for this Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human))	BDBM278400 ((2S)-2-Methoxy-2-phenyl-N-[5-[[(3R)-1-pyridazin-3-...) Show SMILES CO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1ccccc1 |r| Show InChI InChI=1S/C19H21N7O2S/c1-28-16(13-6-3-2-4-7-13)17(27)22-19-25-24-18(29-19)21-14-9-11-26(12-14)15-8-5-10-20-23-15/h2-8,10,14,16H,9,11-12H2,1H3,(H,21,24)(H,22,25,27)/t14-,16+/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid PDB UniChem	PDB US Patent	n/a	n/a	21.3	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company					Assay Description A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...				Bioorg Med Chem Lett 18: 1577-82 (2008) BindingDB Entry DOI: 10.7270/Q2MK6G78
					More data for this Ligand-Target Pair				3D Structure (crystal)
Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human))	BDBM278400 ((2S)-2-Methoxy-2-phenyl-N-[5-[[(3R)-1-pyridazin-3-...) Show SMILES CO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1ccccc1 |r| Show InChI InChI=1S/C19H21N7O2S/c1-28-16(13-6-3-2-4-7-13)17(27)22-19-25-24-18(29-19)21-14-9-11-26(12-14)15-8-5-10-20-23-15/h2-8,10,14,16H,9,11-12H2,1H3,(H,21,24)(H,22,25,27)/t14-,16+/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid PDB UniChem	PDB US Patent	n/a	n/a	21.3	n/a	n/a	n/a	n/a	7.8	n/a
AstraZeneca AB; Cancer Research Technology Limited US Patent					Assay Description A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...				US Patent US10040788 (2018) BindingDB Entry DOI: 10.7270/Q2Z321PG
					More data for this Ligand-Target Pair				3D Structure (crystal)
Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human))	BDBM278405 ((2S)-2-Methoxy-2-(3-methoxyphenyl)-N-[5-[[(3R)-1-p...) Show SMILES CO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1cccc(OC)c1 |r| Show InChI InChI=1S/C20H23N7O3S/c1-29-15-6-3-5-13(11-15)17(30-2)18(28)23-20-26-25-19(31-20)22-14-8-10-27(12-14)16-7-4-9-21-24-16/h3-7,9,11,14,17H,8,10,12H2,1-2H3,(H,22,25)(H,23,26,28)/t14-,17+/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	21.5	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company					Assay Description A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...				Bioorg Med Chem Lett 18: 1577-82 (2008) BindingDB Entry DOI: 10.7270/Q2MK6G78
					More data for this Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human))	BDBM278405 ((2S)-2-Methoxy-2-(3-methoxyphenyl)-N-[5-[[(3R)-1-p...) Show SMILES CO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1cccc(OC)c1 |r| Show InChI InChI=1S/C20H23N7O3S/c1-29-15-6-3-5-13(11-15)17(30-2)18(28)23-20-26-25-19(31-20)22-14-8-10-27(12-14)16-7-4-9-21-24-16/h3-7,9,11,14,17H,8,10,12H2,1-2H3,(H,22,25)(H,23,26,28)/t14-,17+/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	21.5	n/a	n/a	n/a	n/a	7.8	n/a
AstraZeneca AB; Cancer Research Technology Limited US Patent					Assay Description A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...				US Patent US10040788 (2018) BindingDB Entry DOI: 10.7270/Q2Z321PG
					More data for this Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human))	BDBM278418 ((2S)-2-(4-Fluorophenyl)-2-methoxy-N-[5-[[(3R)-1-py...) Show SMILES CO[C@@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1ccc(F)cc1 |r| Show InChI InChI=1S/C19H20FN7O2S/c1-29-16(12-4-6-13(20)7-5-12)17(28)23-19-26-25-18(30-19)22-14-8-10-27(11-14)15-3-2-9-21-24-15/h2-7,9,14,16H,8,10-11H2,1H3,(H,22,25)(H,23,26,28)/t14-,16-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	22	n/a	n/a	n/a	n/a	7.8	n/a
AstraZeneca AB; Cancer Research Technology Limited US Patent					Assay Description A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...				US Patent US10040788 (2018) BindingDB Entry DOI: 10.7270/Q2Z321PG
					More data for this Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human))	BDBM387835 ((2S)-2-(4-Fluorophenyl)-2-methoxy-N-[5-[[(3R)-1-py...) Show SMILES CO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1ccc(F)cc1 |r| Show InChI InChI=1S/C19H20FN7O2S/c1-29-16(12-4-6-13(20)7-5-12)17(28)23-19-26-25-18(30-19)22-14-8-10-27(11-14)15-3-2-9-21-24-15/h2-7,9,14,16H,8,10-11H2,1H3,(H,22,25)(H,23,26,28)/t14-,16+/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	22	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company					Assay Description A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...				Bioorg Med Chem Lett 18: 1577-82 (2008) BindingDB Entry DOI: 10.7270/Q2MK6G78
					More data for this Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human))	BDBM278422 ((2S)-2-(4-Fluoro-3-methoxy-phenyl)-2-methoxy-N-[5-...) Show SMILES CO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1ccc(F)c(OC)c1 |r| Show InChI InChI=1S/C20H22FN7O3S/c1-30-15-10-12(5-6-14(15)21)17(31-2)18(29)24-20-27-26-19(32-20)23-13-7-9-28(11-13)16-4-3-8-22-25-16/h3-6,8,10,13,17H,7,9,11H2,1-2H3,(H,23,26)(H,24,27,29)/t13-,17+/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	25.5	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company					Assay Description A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...				Bioorg Med Chem Lett 18: 1577-82 (2008) BindingDB Entry DOI: 10.7270/Q2MK6G78
					More data for this Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human))	BDBM278422 ((2S)-2-(4-Fluoro-3-methoxy-phenyl)-2-methoxy-N-[5-...) Show SMILES CO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1ccc(F)c(OC)c1 |r| Show InChI InChI=1S/C20H22FN7O3S/c1-30-15-10-12(5-6-14(15)21)17(31-2)18(29)24-20-27-26-19(32-20)23-13-7-9-28(11-13)16-4-3-8-22-25-16/h3-6,8,10,13,17H,7,9,11H2,1-2H3,(H,23,26)(H,24,27,29)/t13-,17+/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	25.5	n/a	n/a	n/a	n/a	7.8	n/a
AstraZeneca AB; Cancer Research Technology Limited US Patent					Assay Description A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...				US Patent US10040788 (2018) BindingDB Entry DOI: 10.7270/Q2Z321PG
					More data for this Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human))	BDBM278420 ((2S)-2-Ethoxy-2-(4-fluorophenyl)-N-[5-[[(3R)-1-pyr...) Show SMILES CCO[C@@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1ccc(F)cc1 |r| Show InChI InChI=1S/C20H22FN7O2S/c1-2-30-17(13-5-7-14(21)8-6-13)18(29)24-20-27-26-19(31-20)23-15-9-11-28(12-15)16-4-3-10-22-25-16/h3-8,10,15,17H,2,9,11-12H2,1H3,(H,23,26)(H,24,27,29)/t15-,17-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	27	n/a	n/a	n/a	n/a	7.8	n/a
AstraZeneca AB; Cancer Research Technology Limited US Patent					Assay Description A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...				US Patent US10040788 (2018) BindingDB Entry DOI: 10.7270/Q2Z321PG
					More data for this Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human))	BDBM387837 ((2S)-2-Ethoxy-2-(4-fluorophenyl)-N-[5-[[(3R)-1-pyr...) Show SMILES CCO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1ccc(F)cc1 |r| Show InChI InChI=1S/C20H22FN7O2S/c1-2-30-17(13-5-7-14(21)8-6-13)18(29)24-20-27-26-19(31-20)23-15-9-11-28(12-15)16-4-3-10-22-25-16/h3-8,10,15,17H,2,9,11-12H2,1H3,(H,23,26)(H,24,27,29)/t15-,17+/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	27	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company					Assay Description A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...				Bioorg Med Chem Lett 18: 1577-82 (2008) BindingDB Entry DOI: 10.7270/Q2MK6G78
					More data for this Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human))	BDBM278410 ((2R)-2-[3-(Difluoromethoxy)phenyl]-2-methoxy-N-[5-...) Show SMILES CO[C@@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1cccc(OC(F)F)c1 |r| Show InChI InChI=1S/C20H21F2N7O3S/c1-31-16(12-4-2-5-14(10-12)32-18(21)22)17(30)25-20-28-27-19(33-20)24-13-7-9-29(11-13)15-6-3-8-23-26-15/h2-6,8,10,13,16,18H,7,9,11H2,1H3,(H,24,27)(H,25,28,30)/t13-,16-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	27.1	n/a	n/a	n/a	n/a	7.8	n/a
AstraZeneca AB; Cancer Research Technology Limited US Patent					Assay Description A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...				US Patent US10040788 (2018) BindingDB Entry DOI: 10.7270/Q2Z321PG
					More data for this Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human))	BDBM278410 ((2R)-2-[3-(Difluoromethoxy)phenyl]-2-methoxy-N-[5-...) Show SMILES CO[C@@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1cccc(OC(F)F)c1 |r| Show InChI InChI=1S/C20H21F2N7O3S/c1-31-16(12-4-2-5-14(10-12)32-18(21)22)17(30)25-20-28-27-19(33-20)24-13-7-9-29(11-13)15-6-3-8-23-26-15/h2-6,8,10,13,16,18H,7,9,11H2,1H3,(H,24,27)(H,25,28,30)/t13-,16-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	27.1	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company					Assay Description A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...				Bioorg Med Chem Lett 18: 1577-82 (2008) BindingDB Entry DOI: 10.7270/Q2MK6G78
					More data for this Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human))	BDBM278436 (US10040788, Example 23(a) | US10294221, Example 23...) Show SMILES CO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cncnn2)s1)c1cccc(OC(F)F)c1 |r| Show InChI InChI=1S/C19H20F2N8O3S/c1-31-15(11-3-2-4-13(7-11)32-17(20)21)16(30)25-19-28-27-18(33-19)24-12-5-6-29(9-12)14-8-22-10-23-26-14/h2-4,7-8,10,12,15,17H,5-6,9H2,1H3,(H,24,27)(H,25,28,30)/t12-,15+/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	27.6	n/a	n/a	n/a	n/a	7.8	n/a
AstraZeneca AB; Cancer Research Technology Limited US Patent					Assay Description A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...				US Patent US10040788 (2018) BindingDB Entry DOI: 10.7270/Q2Z321PG
					More data for this Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human))	BDBM278415 ((2S)-2-Ethoxy-2-phenyl-N-[5-[[(3R)-1-pyridazin-3-y...) Show SMILES CCO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1ccccc1 |r| Show InChI InChI=1S/C20H23N7O2S/c1-2-29-17(14-7-4-3-5-8-14)18(28)23-20-26-25-19(30-20)22-15-10-12-27(13-15)16-9-6-11-21-24-16/h3-9,11,15,17H,2,10,12-13H2,1H3,(H,22,25)(H,23,26,28)/t15-,17+/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	27.6	n/a	n/a	n/a	n/a	7.8	n/a
AstraZeneca AB; Cancer Research Technology Limited US Patent					Assay Description A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...				US Patent US10040788 (2018) BindingDB Entry DOI: 10.7270/Q2Z321PG
					More data for this Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human))	BDBM387853 (US10294221, Example 23(a)) Show SMILES CO[C@@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cncnn2)s1)c1cccc(OC(F)F)c1 |r| Show InChI InChI=1S/C19H20F2N8O3S/c1-31-15(11-3-2-4-13(7-11)32-17(20)21)16(30)25-19-28-27-18(33-19)24-12-5-6-29(9-12)14-8-22-10-23-26-14/h2-4,7-8,10,12,15,17H,5-6,9H2,1H3,(H,24,27)(H,25,28,30)/t12-,15-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	27.6	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company					Assay Description A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...				Bioorg Med Chem Lett 18: 1577-82 (2008) BindingDB Entry DOI: 10.7270/Q2MK6G78
					More data for this Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human))	BDBM278415 ((2S)-2-Ethoxy-2-phenyl-N-[5-[[(3R)-1-pyridazin-3-y...) Show SMILES CCO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1ccccc1 |r| Show InChI InChI=1S/C20H23N7O2S/c1-2-29-17(14-7-4-3-5-8-14)18(28)23-20-26-25-19(30-20)22-15-10-12-27(13-15)16-9-6-11-21-24-16/h3-9,11,15,17H,2,10,12-13H2,1H3,(H,22,25)(H,23,26,28)/t15-,17+/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	27.6	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company					Assay Description A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...				Bioorg Med Chem Lett 18: 1577-82 (2008) BindingDB Entry DOI: 10.7270/Q2MK6G78
					More data for this Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human))	BDBM50172181 (CHEMBL3810394 | US10040788, Example 3 | US10294221...) Show SMILES CO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cncnn2)s1)c1ccccc1 |r| Show InChI InChI=1S/C18H20N8O2S/c1-28-15(12-5-3-2-4-6-12)16(27)22-18-25-24-17(29-18)21-13-7-8-26(10-13)14-9-19-11-20-23-14/h2-6,9,11,13,15H,7-8,10H2,1H3,(H,21,24)(H,22,25,27)/t13-,15+/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	29	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company					Assay Description A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...				Bioorg Med Chem Lett 18: 1577-82 (2008) BindingDB Entry DOI: 10.7270/Q2MK6G78
					More data for this Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human))	BDBM50172181 (CHEMBL3810394 | US10040788, Example 3 | US10294221...) Show SMILES CO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cncnn2)s1)c1ccccc1 |r| Show InChI InChI=1S/C18H20N8O2S/c1-28-15(12-5-3-2-4-6-12)16(27)22-18-25-24-17(29-18)21-13-7-8-26(10-13)14-9-19-11-20-23-14/h2-6,9,11,13,15H,7-8,10H2,1H3,(H,21,24)(H,22,25,27)/t13-,15+/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	29	n/a	n/a	n/a	n/a	7.8	n/a
AstraZeneca AB; Cancer Research Technology Limited US Patent					Assay Description A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...				US Patent US10040788 (2018) BindingDB Entry DOI: 10.7270/Q2Z321PG
					More data for this Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human))	BDBM278411 ((2S)-2-Methoxy-N-[5-[[(3R)-1-(1,2,4-triazin-3-yl)p...) Show SMILES CO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2nccnn2)s1)c1cccc(OC(F)(F)F)c1 |r| Show InChI InChI=1S/C19H19F3N8O3S/c1-32-14(11-3-2-4-13(9-11)33-19(20,21)22)15(31)26-18-29-28-17(34-18)25-12-5-8-30(10-12)16-23-6-7-24-27-16/h2-4,6-7,9,12,14H,5,8,10H2,1H3,(H,25,28)(H,26,29,31)/t12-,14+/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	30.6	n/a	n/a	n/a	n/a	7.8	n/a
AstraZeneca AB; Cancer Research Technology Limited US Patent					Assay Description A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...				US Patent US10040788 (2018) BindingDB Entry DOI: 10.7270/Q2Z321PG
					More data for this Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human))	BDBM278411 ((2S)-2-Methoxy-N-[5-[[(3R)-1-(1,2,4-triazin-3-yl)p...) Show SMILES CO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2nccnn2)s1)c1cccc(OC(F)(F)F)c1 |r| Show InChI InChI=1S/C19H19F3N8O3S/c1-32-14(11-3-2-4-13(9-11)33-19(20,21)22)15(31)26-18-29-28-17(34-18)25-12-5-8-30(10-12)16-23-6-7-24-27-16/h2-4,6-7,9,12,14H,5,8,10H2,1H3,(H,25,28)(H,26,29,31)/t12-,14+/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	30.6	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company					Assay Description A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...				Bioorg Med Chem Lett 18: 1577-82 (2008) BindingDB Entry DOI: 10.7270/Q2MK6G78
					More data for this Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human))	BDBM50172239 (CHEMBL3809014 | US10040788, Example 11 | US1029422...) Show SMILES CO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1ccc(OC)cc1 |r| Show InChI InChI=1S/C20H23N7O3S/c1-29-15-7-5-13(6-8-15)17(30-2)18(28)23-20-26-25-19(31-20)22-14-9-11-27(12-14)16-4-3-10-21-24-16/h3-8,10,14,17H,9,11-12H2,1-2H3,(H,22,25)(H,23,26,28)/t14-,17+/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	31	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company					Assay Description A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...				Bioorg Med Chem Lett 18: 1577-82 (2008) BindingDB Entry DOI: 10.7270/Q2MK6G78
					More data for this Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human))	BDBM50172239 (CHEMBL3809014 | US10040788, Example 11 | US1029422...) Show SMILES CO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1ccc(OC)cc1 |r| Show InChI InChI=1S/C20H23N7O3S/c1-29-15-7-5-13(6-8-15)17(30-2)18(28)23-20-26-25-19(31-20)22-14-9-11-27(12-14)16-4-3-10-21-24-16/h3-8,10,14,17H,9,11-12H2,1-2H3,(H,22,25)(H,23,26,28)/t14-,17+/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	31	n/a	n/a	n/a	n/a	7.8	n/a
AstraZeneca AB; Cancer Research Technology Limited US Patent					Assay Description A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...				US Patent US10040788 (2018) BindingDB Entry DOI: 10.7270/Q2Z321PG
					More data for this Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human))	BDBM278414 ((2R)-2-Methoxy-N-[5-[[(3R)-1-pyridazin-3-ylpyrroli...) Show SMILES CO[C@@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1cccc(OC(F)(F)F)c1 |r| Show InChI InChI=1S/C20H20F3N7O3S/c1-32-16(12-4-2-5-14(10-12)33-20(21,22)23)17(31)26-19-29-28-18(34-19)25-13-7-9-30(11-13)15-6-3-8-24-27-15/h2-6,8,10,13,16H,7,9,11H2,1H3,(H,25,28)(H,26,29,31)/t13-,16-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	32.9	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company					Assay Description A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...				Bioorg Med Chem Lett 18: 1577-82 (2008) BindingDB Entry DOI: 10.7270/Q2MK6G78
					More data for this Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human))	BDBM278414 ((2R)-2-Methoxy-N-[5-[[(3R)-1-pyridazin-3-ylpyrroli...) Show SMILES CO[C@@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1cccc(OC(F)(F)F)c1 |r| Show InChI InChI=1S/C20H20F3N7O3S/c1-32-16(12-4-2-5-14(10-12)33-20(21,22)23)17(31)26-19-29-28-18(34-19)25-13-7-9-30(11-13)15-6-3-8-24-27-15/h2-6,8,10,13,16H,7,9,11H2,1H3,(H,25,28)(H,26,29,31)/t13-,16-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	32.9	n/a	n/a	n/a	n/a	7.8	n/a
AstraZeneca AB; Cancer Research Technology Limited US Patent					Assay Description A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...				US Patent US10040788 (2018) BindingDB Entry DOI: 10.7270/Q2Z321PG
					More data for this Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human))	BDBM278445 (US10040788, Example 28(a) | US10294221, Example 28...) Show SMILES CCO[C@@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1ccc(OC)cc1 |r| Show InChI InChI=1S/C21H25N7O3S/c1-3-31-18(14-6-8-16(30-2)9-7-14)19(29)24-21-27-26-20(32-21)23-15-10-12-28(13-15)17-5-4-11-22-25-17/h4-9,11,15,18H,3,10,12-13H2,1-2H3,(H,23,26)(H,24,27,29)/t15-,18-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	34.1	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company					Assay Description A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...				Bioorg Med Chem Lett 18: 1577-82 (2008) BindingDB Entry DOI: 10.7270/Q2MK6G78
					More data for this Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human))	BDBM278445 (US10040788, Example 28(a) | US10294221, Example 28...) Show SMILES CCO[C@@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1ccc(OC)cc1 |r| Show InChI InChI=1S/C21H25N7O3S/c1-3-31-18(14-6-8-16(30-2)9-7-14)19(29)24-21-27-26-20(32-21)23-15-10-12-28(13-15)17-5-4-11-22-25-17/h4-9,11,15,18H,3,10,12-13H2,1-2H3,(H,23,26)(H,24,27,29)/t15-,18-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	34.1	n/a	n/a	n/a	n/a	7.8	n/a
AstraZeneca AB; Cancer Research Technology Limited US Patent					Assay Description A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...				US Patent US10040788 (2018) BindingDB Entry DOI: 10.7270/Q2Z321PG
					More data for this Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human))	BDBM278439 (US10040788, Example 25(a) | US10294221, Example 25...) Show SMILES CO[C@@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1ccc(OC)c(OC)c1 |r| Show InChI InChI=1S/C21H25N7O4S/c1-30-15-7-6-13(11-16(15)31-2)18(32-3)19(29)24-21-27-26-20(33-21)23-14-8-10-28(12-14)17-5-4-9-22-25-17/h4-7,9,11,14,18H,8,10,12H2,1-3H3,(H,23,26)(H,24,27,29)/t14-,18-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	35.4	n/a	n/a	n/a	n/a	7.8	n/a
AstraZeneca AB; Cancer Research Technology Limited US Patent					Assay Description A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...				US Patent US10040788 (2018) BindingDB Entry DOI: 10.7270/Q2Z321PG
					More data for this Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human))	BDBM278439 (US10040788, Example 25(a) | US10294221, Example 25...) Show SMILES CO[C@@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1ccc(OC)c(OC)c1 |r| Show InChI InChI=1S/C21H25N7O4S/c1-30-15-7-6-13(11-16(15)31-2)18(32-3)19(29)24-21-27-26-20(33-21)23-14-8-10-28(12-14)17-5-4-9-22-25-17/h4-7,9,11,14,18H,8,10,12H2,1-3H3,(H,23,26)(H,24,27,29)/t14-,18-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	35.4	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company					Assay Description A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...				Bioorg Med Chem Lett 18: 1577-82 (2008) BindingDB Entry DOI: 10.7270/Q2MK6G78
					More data for this Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human))	BDBM278403 ((2S)-2-Methoxy-2-(3-methoxyphenyl)-N-[5-[[(3R)-1-(...) Show SMILES CO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2nccnn2)s1)c1cccc(OC)c1 |r| Show InChI InChI=1S/C19H22N8O3S/c1-29-14-5-3-4-12(10-14)15(30-2)16(28)23-19-26-25-18(31-19)22-13-6-9-27(11-13)17-20-7-8-21-24-17/h3-5,7-8,10,13,15H,6,9,11H2,1-2H3,(H,22,25)(H,23,26,28)/t13-,15+/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	35.5	n/a	n/a	n/a	n/a	7.8	n/a
AstraZeneca AB; Cancer Research Technology Limited US Patent					Assay Description A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...				US Patent US10040788 (2018) BindingDB Entry DOI: 10.7270/Q2Z321PG
					More data for this Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human))	BDBM278403 ((2S)-2-Methoxy-2-(3-methoxyphenyl)-N-[5-[[(3R)-1-(...) Show SMILES CO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2nccnn2)s1)c1cccc(OC)c1 |r| Show InChI InChI=1S/C19H22N8O3S/c1-29-14-5-3-4-12(10-14)15(30-2)16(28)23-19-26-25-18(31-19)22-13-6-9-27(11-13)17-20-7-8-21-24-17/h3-5,7-8,10,13,15H,6,9,11H2,1-2H3,(H,22,25)(H,23,26,28)/t13-,15+/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	35.5	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company					Assay Description A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...				Bioorg Med Chem Lett 18: 1577-82 (2008) BindingDB Entry DOI: 10.7270/Q2MK6G78
					More data for this Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human))	BDBM278435 (US10040788, Example 22(b)) Show SMILES CO[C@H](C(=O)Nc1nnc(N[C@H]2CCN(C2)c2cncnn2)s1)c1cccc(OC(F)(F)F)c1 |r| Show InChI InChI=1S/C19H19F3N8O3S/c1-32-15(11-3-2-4-13(7-11)33-19(20,21)22)16(31)26-18-29-28-17(34-18)25-12-5-6-30(9-12)14-8-23-10-24-27-14/h2-4,7-8,10,12,15H,5-6,9H2,1H3,(H,25,28)(H,26,29,31)/t12-,15-/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	43.4	n/a	n/a	n/a	n/a	7.8	n/a
AstraZeneca AB; Cancer Research Technology Limited US Patent					Assay Description A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...				US Patent US10040788 (2018) BindingDB Entry DOI: 10.7270/Q2Z321PG
					More data for this Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human))	BDBM278434 (US10040788, Example 22(a) | US10294221, Example 22...) Show SMILES CO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cncnn2)s1)c1cccc(OC(F)(F)F)c1 |r| Show InChI InChI=1S/C19H19F3N8O3S/c1-32-15(11-3-2-4-13(7-11)33-19(20,21)22)16(31)26-18-29-28-17(34-18)25-12-5-6-30(9-12)14-8-23-10-24-27-14/h2-4,7-8,10,12,15H,5-6,9H2,1H3,(H,25,28)(H,26,29,31)/t12-,15+/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	43.4	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company					Assay Description A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...				Bioorg Med Chem Lett 18: 1577-82 (2008) BindingDB Entry DOI: 10.7270/Q2MK6G78
					More data for this Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human))	BDBM278433 (US10040788, Example 21(b)) Show SMILES CO[C@H](C(=O)Nc1nnc(N[C@H]2CCN(C2)c2cncnn2)s1)c1cccc(OC)c1 |r| Show InChI InChI=1S/C19H22N8O3S/c1-29-14-5-3-4-12(8-14)16(30-2)17(28)23-19-26-25-18(31-19)22-13-6-7-27(10-13)15-9-20-11-21-24-15/h3-5,8-9,11,13,16H,6-7,10H2,1-2H3,(H,22,25)(H,23,26,28)/t13-,16-/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	46.9	n/a	n/a	n/a	n/a	7.8	n/a
AstraZeneca AB; Cancer Research Technology Limited US Patent					Assay Description A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...				US Patent US10040788 (2018) BindingDB Entry DOI: 10.7270/Q2Z321PG
					More data for this Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human))	BDBM278432 (US10040788, Example 21(a) | US10294221, Example 21...) Show SMILES CO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cncnn2)s1)c1cccc(OC)c1 |r| Show InChI InChI=1S/C19H22N8O3S/c1-29-14-5-3-4-12(8-14)16(30-2)17(28)23-19-26-25-18(31-19)22-13-6-7-27(10-13)15-9-20-11-21-24-15/h3-5,8-9,11,13,16H,6-7,10H2,1-2H3,(H,22,25)(H,23,26,28)/t13-,16+/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	46.9	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company					Assay Description A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...				Bioorg Med Chem Lett 18: 1577-82 (2008) BindingDB Entry DOI: 10.7270/Q2MK6G78
					More data for this Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human))	BDBM278455 (US10040788, Example 33(a) | US10294221, Example 33...) Show SMILES CCO[C@@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2nccnn2)s1)c1ccc(F)c(OC)c1 |r| Show InChI InChI=1S/C20H23FN8O3S/c1-3-32-16(12-4-5-14(21)15(10-12)31-2)17(30)25-20-28-27-19(33-20)24-13-6-9-29(11-13)18-22-7-8-23-26-18/h4-5,7-8,10,13,16H,3,6,9,11H2,1-2H3,(H,24,27)(H,25,28,30)/t13-,16-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	50.2	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company					Assay Description A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...				Bioorg Med Chem Lett 18: 1577-82 (2008) BindingDB Entry DOI: 10.7270/Q2MK6G78
					More data for this Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human))	BDBM278451 (US10040788, Example 31(a) | US10294221, Example 31...) Show SMILES CCO[C@@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1ccc(F)c(OC)c1 |r| Show InChI InChI=1S/C21H24FN7O3S/c1-3-32-18(13-6-7-15(22)16(11-13)31-2)19(30)25-21-28-27-20(33-21)24-14-8-10-29(12-14)17-5-4-9-23-26-17/h4-7,9,11,14,18H,3,8,10,12H2,1-2H3,(H,24,27)(H,25,28,30)/t14-,18-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	50.2	n/a	n/a	n/a	n/a	7.8	n/a
AstraZeneca AB; Cancer Research Technology Limited US Patent					Assay Description A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...				US Patent US10040788 (2018) BindingDB Entry DOI: 10.7270/Q2Z321PG
					More data for this Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human))	BDBM278455 (US10040788, Example 33(a) | US10294221, Example 33...) Show SMILES CCO[C@@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2nccnn2)s1)c1ccc(F)c(OC)c1 |r| Show InChI InChI=1S/C20H23FN8O3S/c1-3-32-16(12-4-5-14(21)15(10-12)31-2)17(30)25-20-28-27-19(33-20)24-13-6-9-29(11-13)18-22-7-8-23-26-18/h4-5,7-8,10,13,16H,3,6,9,11H2,1-2H3,(H,24,27)(H,25,28,30)/t13-,16-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	50.2	n/a	n/a	n/a	n/a	7.8	n/a
AstraZeneca AB; Cancer Research Technology Limited US Patent					Assay Description A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...				US Patent US10040788 (2018) BindingDB Entry DOI: 10.7270/Q2Z321PG
					More data for this Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human))	BDBM278451 (US10040788, Example 31(a) | US10294221, Example 31...) Show SMILES CCO[C@@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1ccc(F)c(OC)c1 |r| Show InChI InChI=1S/C21H24FN7O3S/c1-3-32-18(13-6-7-15(22)16(11-13)31-2)19(30)25-21-28-27-20(33-21)24-14-8-10-29(12-14)17-5-4-9-23-26-17/h4-7,9,11,14,18H,3,8,10,12H2,1-2H3,(H,24,27)(H,25,28,30)/t14-,18-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	50.2	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company					Assay Description A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...				Bioorg Med Chem Lett 18: 1577-82 (2008) BindingDB Entry DOI: 10.7270/Q2MK6G78
					More data for this Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human))	BDBM278443 (US10040788, Example 27(a) | US10294221, Example 27...) Show SMILES CCO[C@@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2nccnn2)s1)c1cccc(OC)c1 |r| Show InChI InChI=1S/C20H24N8O3S/c1-3-31-16(13-5-4-6-15(11-13)30-2)17(29)24-20-27-26-19(32-20)23-14-7-10-28(12-14)18-21-8-9-22-25-18/h4-6,8-9,11,14,16H,3,7,10,12H2,1-2H3,(H,23,26)(H,24,27,29)/t14-,16-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	50.8	n/a	n/a	n/a	n/a	7.8	n/a
AstraZeneca AB; Cancer Research Technology Limited US Patent					Assay Description A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...				US Patent US10040788 (2018) BindingDB Entry DOI: 10.7270/Q2Z321PG
					More data for this Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human))	BDBM278443 (US10040788, Example 27(a) | US10294221, Example 27...) Show SMILES CCO[C@@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2nccnn2)s1)c1cccc(OC)c1 |r| Show InChI InChI=1S/C20H24N8O3S/c1-3-31-16(13-5-4-6-15(11-13)30-2)17(29)24-20-27-26-19(32-20)23-14-7-10-28(12-14)18-21-8-9-22-25-18/h4-6,8-9,11,14,16H,3,7,10,12H2,1-2H3,(H,23,26)(H,24,27,29)/t14-,16-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	50.8	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company					Assay Description A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...				Bioorg Med Chem Lett 18: 1577-82 (2008) BindingDB Entry DOI: 10.7270/Q2MK6G78
					More data for this Ligand-Target Pair

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