Found 135 hits with Last Name = 'hillertz' and Initial = 'p' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Glucocorticoid receptor
(RAT) | BDBM50014432
(CHEMBL3261407)Show SMILES C[C@@H](CNc1cccc2n(ncc12)-c1ccc(F)cc1)NS(=O)(=O)c1c(C)cc(C)cc1C |r| Show InChI InChI=1S/C25H27FN4O2S/c1-16-12-17(2)25(18(3)13-16)33(31,32)29-19(4)14-27-23-6-5-7-24-22(23)15-28-30(24)21-10-8-20(26)9-11-21/h5-13,15,19,27,29H,14H2,1-4H3/t19-/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid PDB UniChem
Patents
Similars
| PDB Article PubMed
| n/a | n/a | 0.900 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Agonist activity at glucocorticoid receptor in rat PBMC assessed as inhibition of LPS-stimulated TNF-alpha release |
Bioorg Med Chem Lett 24: 2571-7 (2014)
Article DOI: 10.1016/j.bmcl.2014.03.070 BindingDB Entry DOI: 10.7270/Q2JQ12J6 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Glucocorticoid receptor
(Homo sapiens (Human)) | BDBM50014546
(CHEMBL3261410)Show SMILES C[C@@H](CNc1cccc2n(ncc12)-c1ccccc1)NS(=O)(=O)c1c(C)cc(C)cc1C |r| Show InChI InChI=1S/C25H28N4O2S/c1-17-13-18(2)25(19(3)14-17)32(30,31)28-20(4)15-26-23-11-8-12-24-22(23)16-27-29(24)21-9-6-5-7-10-21/h5-14,16,20,26,28H,15H2,1-4H3/t20-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Agonist activity at glucocorticoid receptor in human Chago K1 cells assessed as gene transrepression by Lac-Z reporter gene assay |
Bioorg Med Chem Lett 24: 2571-7 (2014)
Article DOI: 10.1016/j.bmcl.2014.03.070 BindingDB Entry DOI: 10.7270/Q2JQ12J6 |
More data for this Ligand-Target Pair | |
Glucocorticoid receptor
(Homo sapiens (Human)) | BDBM50014432
(CHEMBL3261407)Show SMILES C[C@@H](CNc1cccc2n(ncc12)-c1ccc(F)cc1)NS(=O)(=O)c1c(C)cc(C)cc1C |r| Show InChI InChI=1S/C25H27FN4O2S/c1-16-12-17(2)25(18(3)13-16)33(31,32)29-19(4)14-27-23-6-5-7-24-22(23)15-28-30(24)21-10-8-20(26)9-11-21/h5-13,15,19,27,29H,14H2,1-4H3/t19-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid PDB UniChem
Patents
Similars
| PDB Article PubMed
| n/a | n/a | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Agonist activity at glucocorticoid receptor in human Chago K1 cells assessed as gene transrepression by Lac-Z reporter gene assay |
Bioorg Med Chem Lett 24: 2571-7 (2014)
Article DOI: 10.1016/j.bmcl.2014.03.070 BindingDB Entry DOI: 10.7270/Q2JQ12J6 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Glucocorticoid receptor
(Homo sapiens (Human)) | BDBM50014546
(CHEMBL3261410)Show SMILES C[C@@H](CNc1cccc2n(ncc12)-c1ccccc1)NS(=O)(=O)c1c(C)cc(C)cc1C |r| Show InChI InChI=1S/C25H28N4O2S/c1-17-13-18(2)25(19(3)14-17)32(30,31)28-20(4)15-26-23-11-8-12-24-22(23)16-27-29(24)21-9-6-5-7-10-21/h5-14,16,20,26,28H,15H2,1-4H3/t20-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.60 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Agonist activity at glucocorticoid receptor in human PBMC assessed as inhibition of LPS-stimulated TNF-alpha release |
Bioorg Med Chem Lett 24: 2571-7 (2014)
Article DOI: 10.1016/j.bmcl.2014.03.070 BindingDB Entry DOI: 10.7270/Q2JQ12J6 |
More data for this Ligand-Target Pair | |
Glucocorticoid receptor
(Homo sapiens (Human)) | BDBM50014539
(CHEMBL3261412)Show SMILES C[C@@H](CNc1cccc2n(ncc12)-c1cccnc1)NS(=O)(=O)c1c(C)cc(C)cc1C |r| Show InChI InChI=1S/C24H27N5O2S/c1-16-11-17(2)24(18(3)12-16)32(30,31)28-19(4)13-26-22-8-5-9-23-21(22)15-27-29(23)20-7-6-10-25-14-20/h5-12,14-15,19,26,28H,13H2,1-4H3/t19-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Agonist activity at glucocorticoid receptor in human PBMC assessed as inhibition of LPS-stimulated TNF-alpha release |
Bioorg Med Chem Lett 24: 2571-7 (2014)
Article DOI: 10.1016/j.bmcl.2014.03.070 BindingDB Entry DOI: 10.7270/Q2JQ12J6 |
More data for this Ligand-Target Pair | |
Glucocorticoid receptor
(Homo sapiens (Human)) | BDBM50014444
(CHEMBL3261416)Show SMILES CC(C)[C@@H](CNc1cccc2n(ncc12)-c1ccc(F)cc1)NS(=O)(=O)c1c(C)cc(C)cc1C |r| Show InChI InChI=1S/C27H31FN4O2S/c1-17(2)25(31-35(33,34)27-19(4)13-18(3)14-20(27)5)16-29-24-7-6-8-26-23(24)15-30-32(26)22-11-9-21(28)10-12-22/h6-15,17,25,29,31H,16H2,1-5H3/t25-/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.10 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Agonist activity at glucocorticoid receptor in human PBMC assessed as inhibition of LPS-stimulated TNF-alpha release |
Bioorg Med Chem Lett 24: 2571-7 (2014)
Article DOI: 10.1016/j.bmcl.2014.03.070 BindingDB Entry DOI: 10.7270/Q2JQ12J6 |
More data for this Ligand-Target Pair | |
Glucocorticoid receptor
(Homo sapiens (Human)) | BDBM50014440
(CHEMBL3261408)Show SMILES C[C@@H](CNc1cccc2n(ncc12)-c1ccc(F)nc1)NS(=O)(=O)c1c(C)cc(C)cc1C |r| Show InChI InChI=1S/C24H26FN5O2S/c1-15-10-16(2)24(17(3)11-15)33(31,32)29-18(4)12-26-21-6-5-7-22-20(21)14-28-30(22)19-8-9-23(25)27-13-19/h5-11,13-14,18,26,29H,12H2,1-4H3/t18-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.30 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Agonist activity at glucocorticoid receptor in human Chago K1 cells assessed as gene transrepression by Lac-Z reporter gene assay |
Bioorg Med Chem Lett 24: 2571-7 (2014)
Article DOI: 10.1016/j.bmcl.2014.03.070 BindingDB Entry DOI: 10.7270/Q2JQ12J6 |
More data for this Ligand-Target Pair | |
Glucocorticoid receptor
(Homo sapiens (Human)) | BDBM50014440
(CHEMBL3261408)Show SMILES C[C@@H](CNc1cccc2n(ncc12)-c1ccc(F)nc1)NS(=O)(=O)c1c(C)cc(C)cc1C |r| Show InChI InChI=1S/C24H26FN5O2S/c1-15-10-16(2)24(17(3)11-15)33(31,32)29-18(4)12-26-21-6-5-7-22-20(21)14-28-30(22)19-8-9-23(25)27-13-19/h5-11,13-14,18,26,29H,12H2,1-4H3/t18-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.30 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Binding affinity to human glucocorticoid receptor by fluorescence polarization assay |
Bioorg Med Chem Lett 24: 2571-7 (2014)
Article DOI: 10.1016/j.bmcl.2014.03.070 BindingDB Entry DOI: 10.7270/Q2JQ12J6 |
More data for this Ligand-Target Pair | |
Glucocorticoid receptor
(Homo sapiens (Human)) | BDBM50014539
(CHEMBL3261412)Show SMILES C[C@@H](CNc1cccc2n(ncc12)-c1cccnc1)NS(=O)(=O)c1c(C)cc(C)cc1C |r| Show InChI InChI=1S/C24H27N5O2S/c1-16-11-17(2)24(18(3)12-16)32(30,31)28-19(4)13-26-22-8-5-9-23-21(22)15-27-29(23)20-7-6-10-25-14-20/h5-12,14-15,19,26,28H,13H2,1-4H3/t19-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.60 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Agonist activity at glucocorticoid receptor in human Chago K1 cells assessed as gene transrepression by Lac-Z reporter gene assay |
Bioorg Med Chem Lett 24: 2571-7 (2014)
Article DOI: 10.1016/j.bmcl.2014.03.070 BindingDB Entry DOI: 10.7270/Q2JQ12J6 |
More data for this Ligand-Target Pair | |
Glucocorticoid receptor
(Homo sapiens (Human)) | BDBM50014433
(CHEMBL3261425)Show SMILES C[C@@H](CNc1cccc2n(ncc12)-c1ccc(F)nc1)NS(=O)(=O)c1c(C)nn(C2CCCC2)c1C |r| Show InChI InChI=1S/C25H30FN7O2S/c1-16(31-36(34,35)25-17(2)30-32(18(25)3)19-7-4-5-8-19)13-27-22-9-6-10-23-21(22)15-29-33(23)20-11-12-24(26)28-14-20/h6,9-12,14-16,19,27,31H,4-5,7-8,13H2,1-3H3/t16-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Binding affinity to human glucocorticoid receptor by fluorescence polarization assay |
Bioorg Med Chem Lett 24: 2571-7 (2014)
Article DOI: 10.1016/j.bmcl.2014.03.070 BindingDB Entry DOI: 10.7270/Q2JQ12J6 |
More data for this Ligand-Target Pair | |
Glucocorticoid receptor
(Homo sapiens (Human)) | BDBM50014545
(CHEMBL3261413)Show SMILES C[C@@H](CNc1cccc2n(ncc12)-c1ccc(Cl)cc1)NS(=O)(=O)c1c(C)cc(C)cc1C |r| Show InChI InChI=1S/C25H27ClN4O2S/c1-16-12-17(2)25(18(3)13-16)33(31,32)29-19(4)14-27-23-6-5-7-24-22(23)15-28-30(24)21-10-8-20(26)9-11-21/h5-13,15,19,27,29H,14H2,1-4H3/t19-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3.40 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Binding affinity to human glucocorticoid receptor by fluorescence polarization assay |
Bioorg Med Chem Lett 24: 2571-7 (2014)
Article DOI: 10.1016/j.bmcl.2014.03.070 BindingDB Entry DOI: 10.7270/Q2JQ12J6 |
More data for this Ligand-Target Pair | |
Glucocorticoid receptor
(Homo sapiens (Human)) | BDBM50014546
(CHEMBL3261410)Show SMILES C[C@@H](CNc1cccc2n(ncc12)-c1ccccc1)NS(=O)(=O)c1c(C)cc(C)cc1C |r| Show InChI InChI=1S/C25H28N4O2S/c1-17-13-18(2)25(19(3)14-17)32(30,31)28-20(4)15-26-23-11-8-12-24-22(23)16-27-29(24)21-9-6-5-7-10-21/h5-14,16,20,26,28H,15H2,1-4H3/t20-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3.5 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Binding affinity to human glucocorticoid receptor by fluorescence polarization assay |
Bioorg Med Chem Lett 24: 2571-7 (2014)
Article DOI: 10.1016/j.bmcl.2014.03.070 BindingDB Entry DOI: 10.7270/Q2JQ12J6 |
More data for this Ligand-Target Pair | |
Glucocorticoid receptor
(Homo sapiens (Human)) | BDBM50014545
(CHEMBL3261413)Show SMILES C[C@@H](CNc1cccc2n(ncc12)-c1ccc(Cl)cc1)NS(=O)(=O)c1c(C)cc(C)cc1C |r| Show InChI InChI=1S/C25H27ClN4O2S/c1-16-12-17(2)25(18(3)13-16)33(31,32)29-19(4)14-27-23-6-5-7-24-22(23)15-28-30(24)21-10-8-20(26)9-11-21/h5-13,15,19,27,29H,14H2,1-4H3/t19-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3.70 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Agonist activity at glucocorticoid receptor in human Chago K1 cells assessed as gene transrepression by Lac-Z reporter gene assay |
Bioorg Med Chem Lett 24: 2571-7 (2014)
Article DOI: 10.1016/j.bmcl.2014.03.070 BindingDB Entry DOI: 10.7270/Q2JQ12J6 |
More data for this Ligand-Target Pair | |
Glucocorticoid receptor
(Homo sapiens (Human)) | BDBM50014541
(CHEMBL3261409)Show SMILES C[C@@H](CNc1cccc2n(ncc12)-c1cccc(C)c1)NS(=O)(=O)c1c(C)cc(C)cc1C |r| Show InChI InChI=1S/C26H30N4O2S/c1-17-8-6-9-22(14-17)30-25-11-7-10-24(23(25)16-28-30)27-15-21(5)29-33(31,32)26-19(3)12-18(2)13-20(26)4/h6-14,16,21,27,29H,15H2,1-5H3/t21-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 3.80 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Binding affinity to human glucocorticoid receptor by fluorescence polarization assay |
Bioorg Med Chem Lett 24: 2571-7 (2014)
Article DOI: 10.1016/j.bmcl.2014.03.070 BindingDB Entry DOI: 10.7270/Q2JQ12J6 |
More data for this Ligand-Target Pair | |
Glucocorticoid receptor
(Homo sapiens (Human)) | BDBM50014431
(CHEMBL3261423)Show SMILES Cc1cc(C)c(c(C)c1)S(=O)(=O)NC(COc1cccc2n(ncc12)-c1ccc(F)cc1)C(F)(F)F Show InChI InChI=1S/C25H23F4N3O3S/c1-15-11-16(2)24(17(3)12-15)36(33,34)31-23(25(27,28)29)14-35-22-6-4-5-21-20(22)13-30-32(21)19-9-7-18(26)8-10-19/h4-13,23,31H,14H2,1-3H3 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3.80 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Binding affinity to human glucocorticoid receptor by fluorescence polarization assay |
Bioorg Med Chem Lett 24: 2571-7 (2014)
Article DOI: 10.1016/j.bmcl.2014.03.070 BindingDB Entry DOI: 10.7270/Q2JQ12J6 |
More data for this Ligand-Target Pair | |
Glucocorticoid receptor
(Homo sapiens (Human)) | BDBM50014543
(CHEMBL3261424)Show SMILES C[C@@H](CNc1cccc2n(ncc12)-c1ccc(F)cc1)NS(=O)(=O)c1c(C)nn(C2CCCC2)c1C |r| Show InChI InChI=1S/C26H31FN6O2S/c1-17(31-36(34,35)26-18(2)30-32(19(26)3)21-7-4-5-8-21)15-28-24-9-6-10-25-23(24)16-29-33(25)22-13-11-20(27)12-14-22/h6,9-14,16-17,21,28,31H,4-5,7-8,15H2,1-3H3/t17-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3.80 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Binding affinity to human glucocorticoid receptor by fluorescence polarization assay |
Bioorg Med Chem Lett 24: 2571-7 (2014)
Article DOI: 10.1016/j.bmcl.2014.03.070 BindingDB Entry DOI: 10.7270/Q2JQ12J6 |
More data for this Ligand-Target Pair | |
Glucocorticoid receptor
(Homo sapiens (Human)) | BDBM50014536
(CHEMBL3261415)Show SMILES C[C@@H](CNc1cccc2n(ncc12)-c1ccc(C)cc1)NS(=O)(=O)c1c(C)cc(C)cc1C |r| Show InChI InChI=1S/C26H30N4O2S/c1-17-9-11-22(12-10-17)30-25-8-6-7-24(23(25)16-28-30)27-15-21(5)29-33(31,32)26-19(3)13-18(2)14-20(26)4/h6-14,16,21,27,29H,15H2,1-5H3/t21-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3.90 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Binding affinity to human glucocorticoid receptor by fluorescence polarization assay |
Bioorg Med Chem Lett 24: 2571-7 (2014)
Article DOI: 10.1016/j.bmcl.2014.03.070 BindingDB Entry DOI: 10.7270/Q2JQ12J6 |
More data for this Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM50390701
(CHEMBL2070229)Show SMILES Clc1ccc(cc1)C1(CC1)C(=O)N1CCC(C1)c1c[nH]c2ncccc12 Show InChI InChI=1S/C21H20ClN3O/c22-16-5-3-15(4-6-16)21(8-9-21)20(26)25-11-7-14(13-25)18-12-24-19-17(18)2-1-10-23-19/h1-6,10,12,14H,7-9,11,13H2,(H,23,24) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck-Serono S.A.
Curated by ChEMBL
| Assay Description Inhibition of human recombinant 11beta-HSD1 expressed in Escherichia coli assessed as conversion of cortisone to cortisol level after 150 mins by HTR... |
Bioorg Med Chem Lett 22: 5909-14 (2012)
Article DOI: 10.1016/j.bmcl.2012.07.070 BindingDB Entry DOI: 10.7270/Q2Z89DH5 |
More data for this Ligand-Target Pair | |
Glucocorticoid receptor
(Homo sapiens (Human)) | BDBM50014442
(CHEMBL3261417)Show SMILES C[C@@H](CNc1cccc2n(ncc12)-c1cccc(F)c1)NS(=O)(=O)c1c(C)cc(C)cc1C |r| Show InChI InChI=1S/C25H27FN4O2S/c1-16-11-17(2)25(18(3)12-16)33(31,32)29-19(4)14-27-23-9-6-10-24-22(23)15-28-30(24)21-8-5-7-20(26)13-21/h5-13,15,19,27,29H,14H2,1-4H3/t19-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Binding affinity to human glucocorticoid receptor by fluorescence polarization assay |
Bioorg Med Chem Lett 24: 2571-7 (2014)
Article DOI: 10.1016/j.bmcl.2014.03.070 BindingDB Entry DOI: 10.7270/Q2JQ12J6 |
More data for this Ligand-Target Pair | |
Glucocorticoid receptor
(Homo sapiens (Human)) | BDBM50014441
(CHEMBL3261414)Show SMILES C[C@@H](CNc1cccc2n(ncc12)-c1ccc(F)c(C)c1)NS(=O)(=O)c1c(C)cc(C)cc1C |r| Show InChI InChI=1S/C26H29FN4O2S/c1-16-11-18(3)26(19(4)12-16)34(32,33)30-20(5)14-28-24-7-6-8-25-22(24)15-29-31(25)21-9-10-23(27)17(2)13-21/h6-13,15,20,28,30H,14H2,1-5H3/t20-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4.10 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Binding affinity to human glucocorticoid receptor by fluorescence polarization assay |
Bioorg Med Chem Lett 24: 2571-7 (2014)
Article DOI: 10.1016/j.bmcl.2014.03.070 BindingDB Entry DOI: 10.7270/Q2JQ12J6 |
More data for this Ligand-Target Pair | |
Glucocorticoid receptor
(Homo sapiens (Human)) | BDBM50014536
(CHEMBL3261415)Show SMILES C[C@@H](CNc1cccc2n(ncc12)-c1ccc(C)cc1)NS(=O)(=O)c1c(C)cc(C)cc1C |r| Show InChI InChI=1S/C26H30N4O2S/c1-17-9-11-22(12-10-17)30-25-8-6-7-24(23(25)16-28-30)27-15-21(5)29-33(31,32)26-19(3)13-18(2)14-20(26)4/h6-14,16,21,27,29H,15H2,1-5H3/t21-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4.5 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Agonist activity at glucocorticoid receptor in human Chago K1 cells assessed as gene transrepression by Lac-Z reporter gene assay |
Bioorg Med Chem Lett 24: 2571-7 (2014)
Article DOI: 10.1016/j.bmcl.2014.03.070 BindingDB Entry DOI: 10.7270/Q2JQ12J6 |
More data for this Ligand-Target Pair | |
Glucocorticoid receptor
(RAT) | BDBM50014433
(CHEMBL3261425)Show SMILES C[C@@H](CNc1cccc2n(ncc12)-c1ccc(F)nc1)NS(=O)(=O)c1c(C)nn(C2CCCC2)c1C |r| Show InChI InChI=1S/C25H30FN7O2S/c1-16(31-36(34,35)25-17(2)30-32(18(25)3)19-7-4-5-8-19)13-27-22-9-6-10-23-21(22)15-29-33(23)20-11-12-24(26)28-14-20/h6,9-12,14-16,19,27,31H,4-5,7-8,13H2,1-3H3/t16-/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4.5 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Agonist activity at glucocorticoid receptor in rat PBMC assessed as inhibition of LPS-stimulated TNF-alpha release |
Bioorg Med Chem Lett 24: 2571-7 (2014)
Article DOI: 10.1016/j.bmcl.2014.03.070 BindingDB Entry DOI: 10.7270/Q2JQ12J6 |
More data for this Ligand-Target Pair | |
Glucocorticoid receptor
(Homo sapiens (Human)) | BDBM50014439
(CHEMBL3261420)Show SMILES C[C@@H](CCc1cccc2n(ncc12)-c1ccc(F)cc1)NS(=O)(=O)c1c(C)cc(C)cc1C |r| Show InChI InChI=1S/C26H28FN3O2S/c1-17-14-18(2)26(19(3)15-17)33(31,32)29-20(4)8-9-21-6-5-7-25-24(21)16-28-30(25)23-12-10-22(27)11-13-23/h5-7,10-16,20,29H,8-9H2,1-4H3/t20-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 4.60 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Binding affinity to human glucocorticoid receptor by fluorescence polarization assay |
Bioorg Med Chem Lett 24: 2571-7 (2014)
Article DOI: 10.1016/j.bmcl.2014.03.070 BindingDB Entry DOI: 10.7270/Q2JQ12J6 |
More data for this Ligand-Target Pair | |
Glucocorticoid receptor
(Homo sapiens (Human)) | BDBM50014434
(CHEMBL3261427)Show SMILES C[C@@H](CNc1cccc2n(ncc12)-c1ccc(cc1)C#N)NS(=O)(=O)c1c(C)nn(C2CCCC2)c1C |r| Show InChI InChI=1S/C27H31N7O2S/c1-18(32-37(35,36)27-19(2)31-33(20(27)3)22-7-4-5-8-22)16-29-25-9-6-10-26-24(25)17-30-34(26)23-13-11-21(15-28)12-14-23/h6,9-14,17-18,22,29,32H,4-5,7-8,16H2,1-3H3/t18-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 4.70 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Binding affinity to human glucocorticoid receptor by fluorescence polarization assay |
Bioorg Med Chem Lett 24: 2571-7 (2014)
Article DOI: 10.1016/j.bmcl.2014.03.070 BindingDB Entry DOI: 10.7270/Q2JQ12J6 |
More data for this Ligand-Target Pair | |
Glucocorticoid receptor
(Homo sapiens (Human)) | BDBM50014432
(CHEMBL3261407)Show SMILES C[C@@H](CNc1cccc2n(ncc12)-c1ccc(F)cc1)NS(=O)(=O)c1c(C)cc(C)cc1C |r| Show InChI InChI=1S/C25H27FN4O2S/c1-16-12-17(2)25(18(3)13-16)33(31,32)29-19(4)14-27-23-6-5-7-24-22(23)15-28-30(24)21-10-8-20(26)9-11-21/h5-13,15,19,27,29H,14H2,1-4H3/t19-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid PDB UniChem
Patents
Similars
| PDB Article PubMed
| n/a | n/a | 4.90 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Binding affinity to human glucocorticoid receptor by fluorescence polarization assay |
Bioorg Med Chem Lett 24: 2571-7 (2014)
Article DOI: 10.1016/j.bmcl.2014.03.070 BindingDB Entry DOI: 10.7270/Q2JQ12J6 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM50390710
(CHEMBL2070319)Show SMILES Cc1[nH]c2ncccc2c1C1CCN(C1)C(=O)C1(CC1)c1ccc(F)cc1 Show InChI InChI=1S/C22H22FN3O/c1-14-19(18-3-2-11-24-20(18)25-14)15-8-12-26(13-15)21(27)22(9-10-22)16-4-6-17(23)7-5-16/h2-7,11,15H,8-10,12-13H2,1H3,(H,24,25) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck-Serono S.A.
Curated by ChEMBL
| Assay Description Inhibition of human recombinant 11beta-HSD1 expressed in Escherichia coli assessed as conversion of cortisone to cortisol level after 150 mins by HTR... |
Bioorg Med Chem Lett 22: 5909-14 (2012)
Article DOI: 10.1016/j.bmcl.2012.07.070 BindingDB Entry DOI: 10.7270/Q2Z89DH5 |
More data for this Ligand-Target Pair | |
Glucocorticoid receptor
(Homo sapiens (Human)) | BDBM50014531
(CHEMBL3261406)Show SMILES C[C@@H](COc1cccc2n(ncc12)-c1ccc(F)cc1)NS(=O)(=O)c1c(C)cc(C)cc1C |r| Show InChI InChI=1S/C25H26FN3O3S/c1-16-12-17(2)25(18(3)13-16)33(30,31)28-19(4)15-32-24-7-5-6-23-22(24)14-27-29(23)21-10-8-20(26)9-11-21/h5-14,19,28H,15H2,1-4H3/t19-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 5.20 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Binding affinity to human glucocorticoid receptor by fluorescence polarization assay |
Bioorg Med Chem Lett 24: 2571-7 (2014)
Article DOI: 10.1016/j.bmcl.2014.03.070 BindingDB Entry DOI: 10.7270/Q2JQ12J6 |
More data for this Ligand-Target Pair | |
Glucocorticoid receptor
(Homo sapiens (Human)) | BDBM50014537
(CHEMBL3261411)Show SMILES C[C@@H](CNc1cccc2n(ncc12)-c1cncnc1)NS(=O)(=O)c1c(C)cc(C)cc1C |r| Show InChI InChI=1S/C23H26N6O2S/c1-15-8-16(2)23(17(3)9-15)32(30,31)28-18(4)10-26-21-6-5-7-22-20(21)13-27-29(22)19-11-24-14-25-12-19/h5-9,11-14,18,26,28H,10H2,1-4H3/t18-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 5.30 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Binding affinity to human glucocorticoid receptor by fluorescence polarization assay |
Bioorg Med Chem Lett 24: 2571-7 (2014)
Article DOI: 10.1016/j.bmcl.2014.03.070 BindingDB Entry DOI: 10.7270/Q2JQ12J6 |
More data for this Ligand-Target Pair | |
Glucocorticoid receptor
(Homo sapiens (Human)) | BDBM50014538
(CHEMBL3261419)Show SMILES COc1ccc(cc1)-n1ncc2c(NC[C@H](C)NS(=O)(=O)c3c(C)cc(C)cc3C)cccc12 |r| Show InChI InChI=1S/C26H30N4O3S/c1-17-13-18(2)26(19(3)14-17)34(31,32)29-20(4)15-27-24-7-6-8-25-23(24)16-28-30(25)21-9-11-22(33-5)12-10-21/h6-14,16,20,27,29H,15H2,1-5H3/t20-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 5.40 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Binding affinity to human glucocorticoid receptor by fluorescence polarization assay |
Bioorg Med Chem Lett 24: 2571-7 (2014)
Article DOI: 10.1016/j.bmcl.2014.03.070 BindingDB Entry DOI: 10.7270/Q2JQ12J6 |
More data for this Ligand-Target Pair | |
Glucocorticoid receptor
(Homo sapiens (Human)) | BDBM50014539
(CHEMBL3261412)Show SMILES C[C@@H](CNc1cccc2n(ncc12)-c1cccnc1)NS(=O)(=O)c1c(C)cc(C)cc1C |r| Show InChI InChI=1S/C24H27N5O2S/c1-16-11-17(2)24(18(3)12-16)32(30,31)28-19(4)13-26-22-8-5-9-23-21(22)15-27-29(23)20-7-6-10-25-14-20/h5-12,14-15,19,26,28H,13H2,1-4H3/t19-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 5.60 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Binding affinity to human glucocorticoid receptor by fluorescence polarization assay |
Bioorg Med Chem Lett 24: 2571-7 (2014)
Article DOI: 10.1016/j.bmcl.2014.03.070 BindingDB Entry DOI: 10.7270/Q2JQ12J6 |
More data for this Ligand-Target Pair | |
Glucocorticoid receptor
(Homo sapiens (Human)) | BDBM50014447
(CHEMBL3261428)Show SMILES C[C@@H](CNc1cccc2n(ncc12)-c1cncnc1)NS(=O)(=O)c1c(C)nn(C2CCCC2)c1C |r| Show InChI InChI=1S/C24H30N8O2S/c1-16(30-35(33,34)24-17(2)29-31(18(24)3)19-7-4-5-8-19)11-27-22-9-6-10-23-21(22)14-28-32(23)20-12-25-15-26-13-20/h6,9-10,12-16,19,27,30H,4-5,7-8,11H2,1-3H3/t16-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 5.70 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Binding affinity to human glucocorticoid receptor by fluorescence polarization assay |
Bioorg Med Chem Lett 24: 2571-7 (2014)
Article DOI: 10.1016/j.bmcl.2014.03.070 BindingDB Entry DOI: 10.7270/Q2JQ12J6 |
More data for this Ligand-Target Pair | |
Glucocorticoid receptor
(Homo sapiens (Human)) | BDBM50014442
(CHEMBL3261417)Show SMILES C[C@@H](CNc1cccc2n(ncc12)-c1cccc(F)c1)NS(=O)(=O)c1c(C)cc(C)cc1C |r| Show InChI InChI=1S/C25H27FN4O2S/c1-16-11-17(2)25(18(3)12-16)33(31,32)29-19(4)14-27-23-9-6-10-24-22(23)15-28-30(24)21-8-5-7-20(26)13-21/h5-13,15,19,27,29H,14H2,1-4H3/t19-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 6.10 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Agonist activity at glucocorticoid receptor in human Chago K1 cells assessed as gene transrepression by Lac-Z reporter gene assay |
Bioorg Med Chem Lett 24: 2571-7 (2014)
Article DOI: 10.1016/j.bmcl.2014.03.070 BindingDB Entry DOI: 10.7270/Q2JQ12J6 |
More data for this Ligand-Target Pair | |
Glucocorticoid receptor
(Homo sapiens (Human)) | BDBM50014541
(CHEMBL3261409)Show SMILES C[C@@H](CNc1cccc2n(ncc12)-c1cccc(C)c1)NS(=O)(=O)c1c(C)cc(C)cc1C |r| Show InChI InChI=1S/C26H30N4O2S/c1-17-8-6-9-22(14-17)30-25-11-7-10-24(23(25)16-28-30)27-15-21(5)29-33(31,32)26-19(3)12-18(2)13-20(26)4/h6-14,16,21,27,29H,15H2,1-5H3/t21-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 6.60 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Agonist activity at glucocorticoid receptor in human Chago K1 cells assessed as gene transrepression by Lac-Z reporter gene assay |
Bioorg Med Chem Lett 24: 2571-7 (2014)
Article DOI: 10.1016/j.bmcl.2014.03.070 BindingDB Entry DOI: 10.7270/Q2JQ12J6 |
More data for this Ligand-Target Pair | |
Glucocorticoid receptor
(Homo sapiens (Human)) | BDBM50014537
(CHEMBL3261411)Show SMILES C[C@@H](CNc1cccc2n(ncc12)-c1cncnc1)NS(=O)(=O)c1c(C)cc(C)cc1C |r| Show InChI InChI=1S/C23H26N6O2S/c1-15-8-16(2)23(17(3)9-15)32(30,31)28-18(4)10-26-21-6-5-7-22-20(21)13-27-29(22)19-11-24-14-25-12-19/h5-9,11-14,18,26,28H,10H2,1-4H3/t18-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 6.90 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Agonist activity at glucocorticoid receptor in human Chago K1 cells assessed as gene transrepression by Lac-Z reporter gene assay |
Bioorg Med Chem Lett 24: 2571-7 (2014)
Article DOI: 10.1016/j.bmcl.2014.03.070 BindingDB Entry DOI: 10.7270/Q2JQ12J6 |
More data for this Ligand-Target Pair | |
Glucocorticoid receptor
(Homo sapiens (Human)) | BDBM50014445
(CHEMBL3261418)Show SMILES COc1cccc(c1)-n1ncc2c(NC[C@H](C)NS(=O)(=O)c3c(C)cc(C)cc3C)cccc12 |r| Show InChI InChI=1S/C26H30N4O3S/c1-17-12-18(2)26(19(3)13-17)34(31,32)29-20(4)15-27-24-10-7-11-25-23(24)16-28-30(25)21-8-6-9-22(14-21)33-5/h6-14,16,20,27,29H,15H2,1-5H3/t20-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 6.90 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Binding affinity to human glucocorticoid receptor by fluorescence polarization assay |
Bioorg Med Chem Lett 24: 2571-7 (2014)
Article DOI: 10.1016/j.bmcl.2014.03.070 BindingDB Entry DOI: 10.7270/Q2JQ12J6 |
More data for this Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM50390703
(CHEMBL2070231)Show SMILES Clc1ccc(cc1)C1(CCC1)C(=O)N1CCC(C1)c1c[nH]c2ncccc12 Show InChI InChI=1S/C22H22ClN3O/c23-17-6-4-16(5-7-17)22(9-2-10-22)21(27)26-12-8-15(14-26)19-13-25-20-18(19)3-1-11-24-20/h1,3-7,11,13,15H,2,8-10,12,14H2,(H,24,25) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck-Serono S.A.
Curated by ChEMBL
| Assay Description Inhibition of human recombinant 11beta-HSD1 expressed in Escherichia coli assessed as conversion of cortisone to cortisol level after 150 mins by HTR... |
Bioorg Med Chem Lett 22: 5909-14 (2012)
Article DOI: 10.1016/j.bmcl.2012.07.070 BindingDB Entry DOI: 10.7270/Q2Z89DH5 |
More data for this Ligand-Target Pair | |
Glucocorticoid receptor
(Homo sapiens (Human)) | BDBM50014433
(CHEMBL3261425)Show SMILES C[C@@H](CNc1cccc2n(ncc12)-c1ccc(F)nc1)NS(=O)(=O)c1c(C)nn(C2CCCC2)c1C |r| Show InChI InChI=1S/C25H30FN7O2S/c1-16(31-36(34,35)25-17(2)30-32(18(25)3)19-7-4-5-8-19)13-27-22-9-6-10-23-21(22)15-29-33(23)20-11-12-24(26)28-14-20/h6,9-12,14-16,19,27,31H,4-5,7-8,13H2,1-3H3/t16-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 7.20 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Agonist activity at glucocorticoid receptor in human Chago K1 cells assessed as gene transrepression by Lac-Z reporter gene assay |
Bioorg Med Chem Lett 24: 2571-7 (2014)
Article DOI: 10.1016/j.bmcl.2014.03.070 BindingDB Entry DOI: 10.7270/Q2JQ12J6 |
More data for this Ligand-Target Pair | |
Glucocorticoid receptor
(Homo sapiens (Human)) | BDBM50014542
(CHEMBL3261421)Show SMILES CC(CSc1cccc2n(ncc12)-c1ccc(F)cc1)NS(=O)(=O)c1c(C)cc(C)cc1C Show InChI InChI=1S/C25H26FN3O2S2/c1-16-12-17(2)25(18(3)13-16)33(30,31)28-19(4)15-32-24-7-5-6-23-22(24)14-27-29(23)21-10-8-20(26)9-11-21/h5-14,19,28H,15H2,1-4H3 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 7.70 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Binding affinity to human glucocorticoid receptor by fluorescence polarization assay |
Bioorg Med Chem Lett 24: 2571-7 (2014)
Article DOI: 10.1016/j.bmcl.2014.03.070 BindingDB Entry DOI: 10.7270/Q2JQ12J6 |
More data for this Ligand-Target Pair | |
Glucocorticoid receptor
(Homo sapiens (Human)) | BDBM50014537
(CHEMBL3261411)Show SMILES C[C@@H](CNc1cccc2n(ncc12)-c1cncnc1)NS(=O)(=O)c1c(C)cc(C)cc1C |r| Show InChI InChI=1S/C23H26N6O2S/c1-15-8-16(2)23(17(3)9-15)32(30,31)28-18(4)10-26-21-6-5-7-22-20(21)13-27-29(22)19-11-24-14-25-12-19/h5-9,11-14,18,26,28H,10H2,1-4H3/t18-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 8.10 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Agonist activity at glucocorticoid receptor in human PBMC assessed as inhibition of LPS-stimulated TNF-alpha release |
Bioorg Med Chem Lett 24: 2571-7 (2014)
Article DOI: 10.1016/j.bmcl.2014.03.070 BindingDB Entry DOI: 10.7270/Q2JQ12J6 |
More data for this Ligand-Target Pair | |
Glucocorticoid receptor
(Homo sapiens (Human)) | BDBM50014541
(CHEMBL3261409)Show SMILES C[C@@H](CNc1cccc2n(ncc12)-c1cccc(C)c1)NS(=O)(=O)c1c(C)cc(C)cc1C |r| Show InChI InChI=1S/C26H30N4O2S/c1-17-8-6-9-22(14-17)30-25-11-7-10-24(23(25)16-28-30)27-15-21(5)29-33(31,32)26-19(3)12-18(2)13-20(26)4/h6-14,16,21,27,29H,15H2,1-5H3/t21-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 8.80 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Agonist activity at glucocorticoid receptor in human PBMC assessed as inhibition of LPS-stimulated TNF-alpha release |
Bioorg Med Chem Lett 24: 2571-7 (2014)
Article DOI: 10.1016/j.bmcl.2014.03.070 BindingDB Entry DOI: 10.7270/Q2JQ12J6 |
More data for this Ligand-Target Pair | |
Glucocorticoid receptor
(Homo sapiens (Human)) | BDBM50014543
(CHEMBL3261424)Show SMILES C[C@@H](CNc1cccc2n(ncc12)-c1ccc(F)cc1)NS(=O)(=O)c1c(C)nn(C2CCCC2)c1C |r| Show InChI InChI=1S/C26H31FN6O2S/c1-17(31-36(34,35)26-18(2)30-32(19(26)3)21-7-4-5-8-21)15-28-24-9-6-10-25-23(24)16-29-33(25)22-13-11-20(27)12-14-22/h6,9-14,16-17,21,28,31H,4-5,7-8,15H2,1-3H3/t17-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 9.70 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Agonist activity at glucocorticoid receptor in human Chago K1 cells assessed as gene transrepression by Lac-Z reporter gene assay |
Bioorg Med Chem Lett 24: 2571-7 (2014)
Article DOI: 10.1016/j.bmcl.2014.03.070 BindingDB Entry DOI: 10.7270/Q2JQ12J6 |
More data for this Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM50390702
(CHEMBL2070230)Show SMILES CC(C)(C(=O)N1CCC(C1)c1c[nH]c2ncccc12)c1ccc(Cl)cc1 Show InChI InChI=1S/C21H22ClN3O/c1-21(2,15-5-7-16(22)8-6-15)20(26)25-11-9-14(13-25)18-12-24-19-17(18)4-3-10-23-19/h3-8,10,12,14H,9,11,13H2,1-2H3,(H,23,24) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck-Serono S.A.
Curated by ChEMBL
| Assay Description Inhibition of human recombinant 11beta-HSD1 expressed in Escherichia coli assessed as conversion of cortisone to cortisol level after 150 mins by HTR... |
Bioorg Med Chem Lett 22: 5909-14 (2012)
Article DOI: 10.1016/j.bmcl.2012.07.070 BindingDB Entry DOI: 10.7270/Q2Z89DH5 |
More data for this Ligand-Target Pair | |
Glucocorticoid receptor
(Homo sapiens (Human)) | BDBM50014439
(CHEMBL3261420)Show SMILES C[C@@H](CCc1cccc2n(ncc12)-c1ccc(F)cc1)NS(=O)(=O)c1c(C)cc(C)cc1C |r| Show InChI InChI=1S/C26H28FN3O2S/c1-17-14-18(2)26(19(3)15-17)33(31,32)29-20(4)8-9-21-6-5-7-25-24(21)16-28-30(25)23-12-10-22(27)11-13-23/h5-7,10-16,20,29H,8-9H2,1-4H3/t20-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Agonist activity at glucocorticoid receptor in human PBMC assessed as inhibition of LPS-stimulated TNF-alpha release |
Bioorg Med Chem Lett 24: 2571-7 (2014)
Article DOI: 10.1016/j.bmcl.2014.03.070 BindingDB Entry DOI: 10.7270/Q2JQ12J6 |
More data for this Ligand-Target Pair | |
Glucocorticoid receptor
(Homo sapiens (Human)) | BDBM50014444
(CHEMBL3261416)Show SMILES CC(C)[C@@H](CNc1cccc2n(ncc12)-c1ccc(F)cc1)NS(=O)(=O)c1c(C)cc(C)cc1C |r| Show InChI InChI=1S/C27H31FN4O2S/c1-17(2)25(31-35(33,34)27-19(4)13-18(3)14-20(27)5)16-29-24-7-6-8-26-23(24)15-30-32(26)22-11-9-21(28)10-12-22/h6-15,17,25,29,31H,16H2,1-5H3/t25-/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Agonist activity at glucocorticoid receptor in human Chago K1 cells assessed as gene transrepression by Lac-Z reporter gene assay |
Bioorg Med Chem Lett 24: 2571-7 (2014)
Article DOI: 10.1016/j.bmcl.2014.03.070 BindingDB Entry DOI: 10.7270/Q2JQ12J6 |
More data for this Ligand-Target Pair | |
Glucocorticoid receptor
(Homo sapiens (Human)) | BDBM50014544
(CHEMBL3261426)Show SMILES C[C@@H](CNc1cccc2n(ncc12)-c1ccc(OC(F)(F)F)cc1)NS(=O)(=O)c1c(C)nn(C2CCCC2)c1C |r| Show InChI InChI=1S/C27H31F3N6O3S/c1-17(34-40(37,38)26-18(2)33-35(19(26)3)20-7-4-5-8-20)15-31-24-9-6-10-25-23(24)16-32-36(25)21-11-13-22(14-12-21)39-27(28,29)30/h6,9-14,16-17,20,31,34H,4-5,7-8,15H2,1-3H3/t17-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Binding affinity to human glucocorticoid receptor by fluorescence polarization assay |
Bioorg Med Chem Lett 24: 2571-7 (2014)
Article DOI: 10.1016/j.bmcl.2014.03.070 BindingDB Entry DOI: 10.7270/Q2JQ12J6 |
More data for this Ligand-Target Pair | |
Glucocorticoid receptor
(Homo sapiens (Human)) | BDBM50014536
(CHEMBL3261415)Show SMILES C[C@@H](CNc1cccc2n(ncc12)-c1ccc(C)cc1)NS(=O)(=O)c1c(C)cc(C)cc1C |r| Show InChI InChI=1S/C26H30N4O2S/c1-17-9-11-22(12-10-17)30-25-8-6-7-24(23(25)16-28-30)27-15-21(5)29-33(31,32)26-19(3)13-18(2)14-20(26)4/h6-14,16,21,27,29H,15H2,1-5H3/t21-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Agonist activity at glucocorticoid receptor in human PBMC assessed as inhibition of LPS-stimulated TNF-alpha release |
Bioorg Med Chem Lett 24: 2571-7 (2014)
Article DOI: 10.1016/j.bmcl.2014.03.070 BindingDB Entry DOI: 10.7270/Q2JQ12J6 |
More data for this Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM50390709
(CHEMBL2070318)Show SMILES Cc1[nH]c2ncccc2c1C1CCN(C1)C(=O)C(C)(C)c1ccc(Cl)cc1 Show InChI InChI=1S/C22H24ClN3O/c1-14-19(18-5-4-11-24-20(18)25-14)15-10-12-26(13-15)21(27)22(2,3)16-6-8-17(23)9-7-16/h4-9,11,15H,10,12-13H2,1-3H3,(H,24,25) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck-Serono S.A.
Curated by ChEMBL
| Assay Description Inhibition of human recombinant 11beta-HSD1 expressed in Escherichia coli assessed as conversion of cortisone to cortisol level after 150 mins by HTR... |
Bioorg Med Chem Lett 22: 5909-14 (2012)
Article DOI: 10.1016/j.bmcl.2012.07.070 BindingDB Entry DOI: 10.7270/Q2Z89DH5 |
More data for this Ligand-Target Pair | |
Glucocorticoid receptor
(Homo sapiens (Human)) | BDBM50014545
(CHEMBL3261413)Show SMILES C[C@@H](CNc1cccc2n(ncc12)-c1ccc(Cl)cc1)NS(=O)(=O)c1c(C)cc(C)cc1C |r| Show InChI InChI=1S/C25H27ClN4O2S/c1-16-12-17(2)25(18(3)13-16)33(31,32)29-19(4)14-27-23-6-5-7-24-22(23)15-28-30(24)21-10-8-20(26)9-11-21/h5-13,15,19,27,29H,14H2,1-4H3/t19-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Agonist activity at glucocorticoid receptor in human PBMC assessed as inhibition of LPS-stimulated TNF-alpha release |
Bioorg Med Chem Lett 24: 2571-7 (2014)
Article DOI: 10.1016/j.bmcl.2014.03.070 BindingDB Entry DOI: 10.7270/Q2JQ12J6 |
More data for this Ligand-Target Pair | |
Glucocorticoid receptor
(Homo sapiens (Human)) | BDBM50014434
(CHEMBL3261427)Show SMILES C[C@@H](CNc1cccc2n(ncc12)-c1ccc(cc1)C#N)NS(=O)(=O)c1c(C)nn(C2CCCC2)c1C |r| Show InChI InChI=1S/C27H31N7O2S/c1-18(32-37(35,36)27-19(2)31-33(20(27)3)22-7-4-5-8-22)16-29-25-9-6-10-26-24(25)17-30-34(26)23-13-11-21(15-28)12-14-23/h6,9-14,17-18,22,29,32H,4-5,7-8,16H2,1-3H3/t18-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Agonist activity at glucocorticoid receptor in human PBMC assessed as inhibition of LPS-stimulated TNF-alpha release |
Bioorg Med Chem Lett 24: 2571-7 (2014)
Article DOI: 10.1016/j.bmcl.2014.03.070 BindingDB Entry DOI: 10.7270/Q2JQ12J6 |
More data for this Ligand-Target Pair | |
Glucocorticoid receptor
(Homo sapiens (Human)) | BDBM50014433
(CHEMBL3261425)Show SMILES C[C@@H](CNc1cccc2n(ncc12)-c1ccc(F)nc1)NS(=O)(=O)c1c(C)nn(C2CCCC2)c1C |r| Show InChI InChI=1S/C25H30FN7O2S/c1-16(31-36(34,35)25-17(2)30-32(18(25)3)19-7-4-5-8-19)13-27-22-9-6-10-23-21(22)15-29-33(23)20-11-12-24(26)28-14-20/h6,9-12,14-16,19,27,31H,4-5,7-8,13H2,1-3H3/t16-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Agonist activity at glucocorticoid receptor in human PBMC assessed as inhibition of LPS-stimulated TNF-alpha release |
Bioorg Med Chem Lett 24: 2571-7 (2014)
Article DOI: 10.1016/j.bmcl.2014.03.070 BindingDB Entry DOI: 10.7270/Q2JQ12J6 |
More data for this Ligand-Target Pair | |