Found 483 hits with Last Name = 'izawa' and Initial = 't' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
ATP-binding cassette sub-family C member 2
(Homo sapiens (Human)) | BDBM50420182
(CHEMBL2074650)Show SMILES C[C@@H]1C[C@@H](C)OP(=O)(O1)c1c(C)nc(C)c(C(=O)OCCN2CCN(CC2)C(c2ccccc2)c2ccccc2)c1-c1cccc(c1)[N+]([O-])=O |r| Show InChI InChI=1S/C38H43N4O7P/c1-26-24-27(2)49-50(46,48-26)37-29(4)39-28(3)34(35(37)32-16-11-17-33(25-32)42(44)45)38(43)47-23-22-40-18-20-41(21-19-40)36(30-12-7-5-8-13-30)31-14-9-6-10-15-31/h5-17,25-27,36H,18-24H2,1-4H3/t26-,27-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| PubMed
| 3.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kagoshima University
Curated by ChEMBL
| Assay Description TP_TRANSPORTER: inhibition of LTC4 uptake in membrane vesicles from MRP2-expressing LLC PK1 cells |
Mol Pharmacol 56: 1219-28 (1999)
BindingDB Entry DOI: 10.7270/Q2RJ4KQX |
More data for this Ligand-Target Pair | |
ATP-binding cassette sub-family C member 2
(Homo sapiens (Human)) | BDBM50022815
((3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-ethyl-33...)Show SMILES CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O)C(C)C |r| Show InChI InChI=1S/C62H111N11O12/c1-25-27-28-40(15)52(75)51-56(79)65-43(26-2)58(81)67(18)33-48(74)68(19)44(29-34(3)4)55(78)66-49(38(11)12)61(84)69(20)45(30-35(5)6)54(77)63-41(16)53(76)64-42(17)57(80)70(21)46(31-36(7)8)59(82)71(22)47(32-37(9)10)60(83)72(23)50(39(13)14)62(85)73(51)24/h25,27,34-47,49-52,75H,26,28-33H2,1-24H3,(H,63,77)(H,64,76)(H,65,79)(H,66,78)/b27-25+/t40-,41+,42-,43+,44+,45+,46+,47+,49+,50+,51+,52-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| Purchase
MCE KEGG MMDB PC cid PC sid UniChem
Patents
Similars
| PubMed
| 4.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kagoshima University
Curated by ChEMBL
| Assay Description TP_TRANSPORTER: inhibition of LTC4 uptake in membrane vesicles from MRP2-expressing LLC PK1 cells |
Mol Pharmacol 56: 1219-28 (1999)
BindingDB Entry DOI: 10.7270/Q2RJ4KQX |
More data for this Ligand-Target Pair | |
ATP-binding cassette sub-family C member 2
(Homo sapiens (Human)) | BDBM50001285
((E)-3-((3-(2-(7-chloroquinolin-2-yl)vinyl)phenyl)(...)Show SMILES CN(C)C(=O)CCSC(SCCC(O)=O)c1cccc(\C=C\c2ccc3ccc(Cl)cc3n2)c1 Show InChI InChI=1S/C26H27ClN2O3S2/c1-29(2)24(30)12-14-33-26(34-15-13-25(31)32)20-5-3-4-18(16-20)6-10-22-11-8-19-7-9-21(27)17-23(19)28-22/h3-11,16-17,26H,12-15H2,1-2H3,(H,31,32)/b10-6+ | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE KEGG PC cid PC sid UniChem
Patents
Similars
| PubMed
| 1.31E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kagoshima University
Curated by ChEMBL
| Assay Description TP_TRANSPORTER: inhibition of LTC4 uptake in membrane vesicles from MRP2-expressing LLC PK1 cells |
Mol Pharmacol 56: 1219-28 (1999)
BindingDB Entry DOI: 10.7270/Q2RJ4KQX |
More data for this Ligand-Target Pair | |
ATP-binding cassette sub-family C member 2
(Homo sapiens (Human)) | BDBM50390978
(VALSPODAR)Show SMILES C\C=C\C[C@@H](C)C(=O)[C@@H]1N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C(=O)[C@@H](NC1=O)C(C)C)C(C)C |r| Show InChI InChI=1S/C63H111N11O12/c1-26-27-28-41(16)53(76)52-57(80)67-49(38(10)11)61(84)68(19)33-48(75)69(20)44(29-34(2)3)56(79)66-50(39(12)13)62(85)70(21)45(30-35(4)5)55(78)64-42(17)54(77)65-43(18)58(81)71(22)46(31-36(6)7)59(82)72(23)47(32-37(8)9)60(83)73(24)51(40(14)15)63(86)74(52)25/h26-27,34-47,49-52H,28-33H2,1-25H3,(H,64,78)(H,65,77)(H,66,79)(H,67,80)/b27-26+/t41-,42+,43-,44+,45+,46+,47+,49+,50+,51+,52+/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| Purchase
MCE KEGG PC cid PC sid UniChem
Similars
| PubMed
| 2.89E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kagoshima University
Curated by ChEMBL
| Assay Description TP_TRANSPORTER: inhibition of LTC4 uptake in membrane vesicles from MRP2-expressing LLC PK1 cells |
Mol Pharmacol 56: 1219-28 (1999)
BindingDB Entry DOI: 10.7270/Q2RJ4KQX |
More data for this Ligand-Target Pair | |
Protein kinase C zeta type
(Homo sapiens (Human)) | BDBM50542127
(CHEMBL4635482)Show SMILES Nc1ccc(c(F)c1)-c1cc(N[C@H]2CCCCNC2)c2ccncc2c1 |r| Show InChI InChI=1S/C21H23FN4/c22-20-11-16(23)4-5-18(20)14-9-15-12-25-8-6-19(15)21(10-14)26-17-3-1-2-7-24-13-17/h4-6,8-12,17,24,26H,1-3,7,13,23H2/t17-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 0.100 | n/a | n/a | n/a | n/a | n/a | n/a |
Asahi Kasei Pharma Corporation
Curated by ChEMBL
| Assay Description Inhibition of recombinant human PKCzeta using biotin-KKKKRFSFKKSFK substrate and ATP incubated for 30 mins by TR-FRET method |
J Med Chem 63: 7143-7162 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00449 BindingDB Entry DOI: 10.7270/Q24T6NWX |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50162143
(1-[4-(6,7-Dimethoxy-quinolin-4-yloxy)-phenyl]-3-m-...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4cccc(C)c4)cc3)c2cc1OC Show InChI InChI=1S/C25H23N3O4/c1-16-5-4-6-18(13-16)28-25(29)27-17-7-9-19(10-8-17)32-22-11-12-26-21-15-24(31-3)23(30-2)14-20(21)22/h4-15H,1-3H3,(H2,27,28,29) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co. Ltd.
Curated by ChEMBL
| Assay Description Inhibition of vascular endothelial growth factor receptor 2 |
J Med Chem 48: 1359-66 (2005)
Article DOI: 10.1021/jm030427r BindingDB Entry DOI: 10.7270/Q23J3CG1 |
More data for this Ligand-Target Pair | |
Protein kinase C zeta type
(Homo sapiens (Human)) | BDBM50542123
(CHEMBL4636488)Show SMILES C1CNC[C@H](C1)Nc1cc(cc2cnccc12)-c1ccccc1 |r| Show InChI InChI=1S/C20H21N3/c1-2-5-15(6-3-1)16-11-17-13-22-10-8-19(17)20(12-16)23-18-7-4-9-21-14-18/h1-3,5-6,8,10-13,18,21,23H,4,7,9,14H2/t18-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a |
Asahi Kasei Pharma Corporation
Curated by ChEMBL
| Assay Description Inhibition of recombinant human PKCzeta using biotin-KKKKRFSFKKSFK substrate and ATP incubated for 30 mins by TR-FRET method |
J Med Chem 63: 7143-7162 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00449 BindingDB Entry DOI: 10.7270/Q24T6NWX |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50162167
(1-[4-(6,7-Dimethoxy-quinolin-4-yloxy)-phenyl]-3-ph...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4ccccc4)cc3)c2cc1OC Show InChI InChI=1S/C24H21N3O4/c1-29-22-14-19-20(15-23(22)30-2)25-13-12-21(19)31-18-10-8-17(9-11-18)27-24(28)26-16-6-4-3-5-7-16/h3-15H,1-2H3,(H2,26,27,28) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co. Ltd.
Curated by ChEMBL
| Assay Description Inhibition of vascular endothelial growth factor receptor 2 |
J Med Chem 48: 1359-66 (2005)
Article DOI: 10.1021/jm030427r BindingDB Entry DOI: 10.7270/Q23J3CG1 |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50162144
(1-(4-Chloro-phenyl)-3-[4-(6,7-dimethoxy-quinolin-4...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4ccc(Cl)cc4)cc3)c2cc1OC Show InChI InChI=1S/C24H20ClN3O4/c1-30-22-13-19-20(14-23(22)31-2)26-12-11-21(19)32-18-9-7-17(8-10-18)28-24(29)27-16-5-3-15(25)4-6-16/h3-14H,1-2H3,(H2,27,28,29) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co. Ltd.
Curated by ChEMBL
| Assay Description Inhibition of vascular endothelial growth factor receptor 2 |
J Med Chem 48: 1359-66 (2005)
Article DOI: 10.1021/jm030427r BindingDB Entry DOI: 10.7270/Q23J3CG1 |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50162154
(1-[4-(6,7-Dimethoxy-quinolin-4-yloxy)-phenyl]-3-(2...)Show SMILES COc1ccccc1NC(=O)Nc1ccc(Oc2ccnc3cc(OC)c(OC)cc23)cc1 Show InChI InChI=1S/C25H23N3O5/c1-30-22-7-5-4-6-19(22)28-25(29)27-16-8-10-17(11-9-16)33-21-12-13-26-20-15-24(32-3)23(31-2)14-18(20)21/h4-15H,1-3H3,(H2,27,28,29) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co. Ltd.
Curated by ChEMBL
| Assay Description Inhibition of vascular endothelial growth factor receptor 2 |
J Med Chem 48: 1359-66 (2005)
Article DOI: 10.1021/jm030427r BindingDB Entry DOI: 10.7270/Q23J3CG1 |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50162166
(1-[2-Chloro-4-(6,7-dimethoxy-quinolin-4-yloxy)-phe...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4ccc(F)cc4F)c(Cl)c3)c2cc1OC Show InChI InChI=1S/C24H18ClF2N3O4/c1-32-22-11-15-20(12-23(22)33-2)28-8-7-21(15)34-14-4-6-18(16(25)10-14)29-24(31)30-19-5-3-13(26)9-17(19)27/h3-12H,1-2H3,(H2,29,30,31) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co. Ltd.
Curated by ChEMBL
| Assay Description Inhibition of vascular endothelial growth factor receptor 2 |
J Med Chem 48: 1359-66 (2005)
Article DOI: 10.1021/jm030427r BindingDB Entry DOI: 10.7270/Q23J3CG1 |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50162168
(1-[4-(6,7-Dimethoxy-quinolin-4-yloxy)-phenyl]-3-(4...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4ccc(F)cc4)cc3)c2cc1OC Show InChI InChI=1S/C24H20FN3O4/c1-30-22-13-19-20(14-23(22)31-2)26-12-11-21(19)32-18-9-7-17(8-10-18)28-24(29)27-16-5-3-15(25)4-6-16/h3-14H,1-2H3,(H2,27,28,29) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co. Ltd.
Curated by ChEMBL
| Assay Description Inhibition of vascular endothelial growth factor receptor 2 |
J Med Chem 48: 1359-66 (2005)
Article DOI: 10.1021/jm030427r BindingDB Entry DOI: 10.7270/Q23J3CG1 |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50162169
(1-(2,5-Difluoro-phenyl)-3-[4-(6,7-dimethoxy-quinol...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4cc(F)ccc4F)cc3)c2cc1OC Show InChI InChI=1S/C24H19F2N3O4/c1-31-22-12-17-19(13-23(22)32-2)27-10-9-21(17)33-16-6-4-15(5-7-16)28-24(30)29-20-11-14(25)3-8-18(20)26/h3-13H,1-2H3,(H2,28,29,30) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co. Ltd.
Curated by ChEMBL
| Assay Description Inhibition of vascular endothelial growth factor receptor 2 |
J Med Chem 48: 1359-66 (2005)
Article DOI: 10.1021/jm030427r BindingDB Entry DOI: 10.7270/Q23J3CG1 |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50162142
(1-[4-(6,7-Dimethoxy-quinolin-4-yloxy)-phenyl]-3-(2...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4ccccc4F)cc3)c2cc1OC Show InChI InChI=1S/C24H20FN3O4/c1-30-22-13-17-20(14-23(22)31-2)26-12-11-21(17)32-16-9-7-15(8-10-16)27-24(29)28-19-6-4-3-5-18(19)25/h3-14H,1-2H3,(H2,27,28,29) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co. Ltd.
Curated by ChEMBL
| Assay Description Inhibition of vascular endothelial growth factor receptor 2 |
J Med Chem 48: 1359-66 (2005)
Article DOI: 10.1021/jm030427r BindingDB Entry DOI: 10.7270/Q23J3CG1 |
More data for this Ligand-Target Pair | |
Protein kinase C zeta type
(Homo sapiens (Human)) | BDBM50542116
(CHEMBL4646995)Show InChI InChI=1S/C20H22N4/c21-17-5-3-14(4-6-17)15-10-16-12-23-9-7-19(16)20(11-15)24-18-2-1-8-22-13-18/h3-7,9-12,18,22,24H,1-2,8,13,21H2 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Asahi Kasei Pharma Corporation
Curated by ChEMBL
| Assay Description Inhibition of recombinant human PKCzeta using biotin-KKKKRFSFKKSFK substrate and ATP incubated for 30 mins by TR-FRET method |
J Med Chem 63: 7143-7162 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00449 BindingDB Entry DOI: 10.7270/Q24T6NWX |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50162155
(1-[4-(6,7-Dimethoxy-quinolin-4-yloxy)-phenyl]-3-p-...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4ccc(C)cc4)cc3)c2cc1OC Show InChI InChI=1S/C25H23N3O4/c1-16-4-6-17(7-5-16)27-25(29)28-18-8-10-19(11-9-18)32-22-12-13-26-21-15-24(31-3)23(30-2)14-20(21)22/h4-15H,1-3H3,(H2,27,28,29) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co. Ltd.
Curated by ChEMBL
| Assay Description Inhibition of vascular endothelial growth factor receptor 2 |
J Med Chem 48: 1359-66 (2005)
Article DOI: 10.1021/jm030427r BindingDB Entry DOI: 10.7270/Q23J3CG1 |
More data for this Ligand-Target Pair | |
Protein kinase C zeta type
(Homo sapiens (Human)) | BDBM50542119
(CHEMBL4644939)Show InChI InChI=1S/C20H21N3O/c24-18-5-3-14(4-6-18)15-10-16-12-22-9-7-19(16)20(11-15)23-17-2-1-8-21-13-17/h3-7,9-12,17,21,23-24H,1-2,8,13H2 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 0.600 | n/a | n/a | n/a | n/a | n/a | n/a |
Asahi Kasei Pharma Corporation
Curated by ChEMBL
| Assay Description Inhibition of recombinant human PKCzeta using biotin-KKKKRFSFKKSFK substrate and ATP incubated for 30 mins by TR-FRET method |
J Med Chem 63: 7143-7162 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00449 BindingDB Entry DOI: 10.7270/Q24T6NWX |
More data for this Ligand-Target Pair | |
cGMP-dependent 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50258896
(CHEMBL4060569 | US11419874, TAK-915)Show SMILES COC[C@@H](NC(=O)N1CC(=O)Nc2cc(OC)cnc12)c1ccc(OC(F)(F)F)c(F)c1 |r| Show InChI InChI=1S/C19H18F4N4O5/c1-30-9-14(10-3-4-15(12(20)5-10)32-19(21,22)23)26-18(29)27-8-16(28)25-13-6-11(31-2)7-24-17(13)27/h3-7,14H,8-9H2,1-2H3,(H,25,28)(H,26,29)/t14-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| Purchase
MCE PC cid PC sid PDB UniChem
Similars
| PDB Article PubMed
| n/a | n/a | 0.610 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
| Assay Description Inhibition of recombinant human FLAG-tagged PDE2A3 expressed in sf21 cells using [3H]cGMP as substrate by scintillation proximity assay |
J Med Chem 60: 7677-7702 (2017)
Article DOI: 10.1021/acs.jmedchem.7b00807 BindingDB Entry DOI: 10.7270/Q2P271JR |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50162148
(1-(2,4-Difluoro-phenyl)-3-[4-(6,7-dimethoxy-quinol...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4ccc(F)cc4F)cc3)c2cc1OC Show InChI InChI=1S/C24H19F2N3O4/c1-31-22-12-17-20(13-23(22)32-2)27-10-9-21(17)33-16-6-4-15(5-7-16)28-24(30)29-19-8-3-14(25)11-18(19)26/h3-13H,1-2H3,(H2,28,29,30) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.700 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co. Ltd.
Curated by ChEMBL
| Assay Description Inhibition of vascular endothelial growth factor receptor 2 |
J Med Chem 48: 1359-66 (2005)
Article DOI: 10.1021/jm030427r BindingDB Entry DOI: 10.7270/Q23J3CG1 |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50162156
(1-(2,3-Difluoro-phenyl)-3-[4-(6,7-dimethoxy-quinol...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4cccc(F)c4F)cc3)c2cc1OC Show InChI InChI=1S/C24H19F2N3O4/c1-31-21-12-16-19(13-22(21)32-2)27-11-10-20(16)33-15-8-6-14(7-9-15)28-24(30)29-18-5-3-4-17(25)23(18)26/h3-13H,1-2H3,(H2,28,29,30) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.700 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co. Ltd.
Curated by ChEMBL
| Assay Description Inhibition of vascular endothelial growth factor receptor 2 |
J Med Chem 48: 1359-66 (2005)
Article DOI: 10.1021/jm030427r BindingDB Entry DOI: 10.7270/Q23J3CG1 |
More data for this Ligand-Target Pair | |
Protein kinase C zeta type
(Homo sapiens (Human)) | BDBM50542128
(CHEMBL4636337)Show SMILES Nc1ccc(c(F)c1F)-c1cc(N[C@H]2CCCCNC2)c2ccncc2c1 |r| Show InChI InChI=1S/C21H22F2N4/c22-20-17(4-5-18(24)21(20)23)13-9-14-11-26-8-6-16(14)19(10-13)27-15-3-1-2-7-25-12-15/h4-6,8-11,15,25,27H,1-3,7,12,24H2/t15-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 0.800 | n/a | n/a | n/a | n/a | n/a | n/a |
Asahi Kasei Pharma Corporation
Curated by ChEMBL
| Assay Description Inhibition of recombinant human PKCzeta using biotin-KKKKRFSFKKSFK substrate and ATP incubated for 30 mins by TR-FRET method |
J Med Chem 63: 7143-7162 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00449 BindingDB Entry DOI: 10.7270/Q24T6NWX |
More data for this Ligand-Target Pair | |
Protein kinase C zeta type
(Homo sapiens (Human)) | BDBM50542132
(CHEMBL4632523)Show SMILES Nc1ccc(cn1)-c1cc(N[C@H]2CCCCNC2)c2ccncc2c1 |r| Show InChI InChI=1S/C20H23N5/c21-20-5-4-14(12-24-20)15-9-16-11-23-8-6-18(16)19(10-15)25-17-3-1-2-7-22-13-17/h4-6,8-12,17,22,25H,1-3,7,13H2,(H2,21,24)/t17-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 0.900 | n/a | n/a | n/a | n/a | n/a | n/a |
Asahi Kasei Pharma Corporation
Curated by ChEMBL
| Assay Description Inhibition of recombinant human PKCzeta using biotin-KKKKRFSFKKSFK substrate and ATP incubated for 30 mins by TR-FRET method |
J Med Chem 63: 7143-7162 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00449 BindingDB Entry DOI: 10.7270/Q24T6NWX |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50162147
(1-(2,4-Difluoro-phenyl)-3-[4-(6,7-dimethoxy-quinol...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4ccc(F)cc4F)c(F)c3)c2cc1OC Show InChI InChI=1S/C24H18F3N3O4/c1-32-22-11-15-20(12-23(22)33-2)28-8-7-21(15)34-14-4-6-19(17(27)10-14)30-24(31)29-18-5-3-13(25)9-16(18)26/h3-12H,1-2H3,(H2,29,30,31) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 0.900 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co. Ltd.
Curated by ChEMBL
| Assay Description Inhibition of vascular endothelial growth factor receptor 2 in cell-intact assay |
J Med Chem 48: 1359-66 (2005)
Article DOI: 10.1021/jm030427r BindingDB Entry DOI: 10.7270/Q23J3CG1 |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50162145
(1-[4-(6,7-Dimethoxy-quinolin-4-yloxy)-phenyl]-3-(3...)Show SMILES COc1cccc(NC(=O)Nc2ccc(Oc3ccnc4cc(OC)c(OC)cc34)cc2)c1 Show InChI InChI=1S/C25H23N3O5/c1-30-19-6-4-5-17(13-19)28-25(29)27-16-7-9-18(10-8-16)33-22-11-12-26-21-15-24(32-3)23(31-2)14-20(21)22/h4-15H,1-3H3,(H2,27,28,29) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | <1 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co. Ltd.
Curated by ChEMBL
| Assay Description Inhibition of vascular endothelial growth factor receptor 2 |
J Med Chem 48: 1359-66 (2005)
Article DOI: 10.1021/jm030427r BindingDB Entry DOI: 10.7270/Q23J3CG1 |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50162160
(1-(2,4-Difluoro-phenyl)-3-[4-(6,7-dimethoxy-quinol...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4ccc(F)cc4F)cc3F)c2cc1OC Show InChI InChI=1S/C24H18F3N3O4/c1-32-22-11-15-19(12-23(22)33-2)28-8-7-20(15)34-21-6-4-14(10-17(21)27)29-24(31)30-18-5-3-13(25)9-16(18)26/h3-12H,1-2H3,(H2,29,30,31) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | <1 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co. Ltd.
Curated by ChEMBL
| Assay Description Inhibition of vascular endothelial growth factor receptor 2 |
J Med Chem 48: 1359-66 (2005)
Article DOI: 10.1021/jm030427r BindingDB Entry DOI: 10.7270/Q23J3CG1 |
More data for this Ligand-Target Pair | |
cGMP-dependent 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM107767
(US11419874, PF-05180999 | US8598155, 2)Show SMILES Cc1nc(-c2cnn(C)c2-c2ccc(cn2)C(F)(F)F)c2c(ncnn12)N1CCC1 Show InChI InChI=1S/C19H17F3N8/c1-11-27-15(17-18(29-6-3-7-29)24-10-26-30(11)17)13-9-25-28(2)16(13)14-5-4-12(8-23-14)19(20,21)22/h4-5,8-10H,3,6-7H2,1-2H3 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| Purchase
MCE PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
| Assay Description Inhibition of recombinant human FLAG-tagged PDE2A3 expressed in sf21 cells using [3H]cGMP as substrate by scintillation proximity assay |
J Med Chem 60: 7677-7702 (2017)
Article DOI: 10.1021/acs.jmedchem.7b00807 BindingDB Entry DOI: 10.7270/Q2P271JR |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50162152
(1-[4-(6,7-Dimethoxy-quinolin-4-yloxy)-phenyl]-3-(4...)Show SMILES COc1ccc(NC(=O)Nc2ccc(Oc3ccnc4cc(OC)c(OC)cc34)cc2)cc1 Show InChI InChI=1S/C25H23N3O5/c1-30-18-8-4-16(5-9-18)27-25(29)28-17-6-10-19(11-7-17)33-22-12-13-26-21-15-24(32-3)23(31-2)14-20(21)22/h4-15H,1-3H3,(H2,27,28,29) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co. Ltd.
Curated by ChEMBL
| Assay Description Inhibition of vascular endothelial growth factor receptor 2 |
J Med Chem 48: 1359-66 (2005)
Article DOI: 10.1021/jm030427r BindingDB Entry DOI: 10.7270/Q23J3CG1 |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50162158
(1-[4-(6,7-Dimethoxy-quinolin-4-yloxy)-phenyl]-3-(3...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4cccc(c4)[N+]([O-])=O)cc3)c2cc1OC Show InChI InChI=1S/C24H20N4O6/c1-32-22-13-19-20(14-23(22)33-2)25-11-10-21(19)34-18-8-6-15(7-9-18)26-24(29)27-16-4-3-5-17(12-16)28(30)31/h3-14H,1-2H3,(H2,26,27,29) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co. Ltd.
Curated by ChEMBL
| Assay Description Inhibition of vascular endothelial growth factor receptor 2 |
J Med Chem 48: 1359-66 (2005)
Article DOI: 10.1021/jm030427r BindingDB Entry DOI: 10.7270/Q23J3CG1 |
More data for this Ligand-Target Pair | |
Protein kinase C zeta type
(Homo sapiens (Human)) | BDBM50542133
(CHEMBL4643553)Show SMILES Nc1ccc(c(F)n1)-c1cc(N[C@H]2CCCCNC2)c2ccncc2c1 |r| Show InChI InChI=1S/C20H22FN5/c21-20-17(4-5-19(22)26-20)13-9-14-11-24-8-6-16(14)18(10-13)25-15-3-1-2-7-23-12-15/h4-6,8-11,15,23,25H,1-3,7,12H2,(H2,22,26)/t15-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Asahi Kasei Pharma Corporation
Curated by ChEMBL
| Assay Description Inhibition of recombinant human PKCzeta using biotin-KKKKRFSFKKSFK substrate and ATP incubated for 30 mins by TR-FRET method |
J Med Chem 63: 7143-7162 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00449 BindingDB Entry DOI: 10.7270/Q24T6NWX |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50162140
(1-(3,4-Difluoro-phenyl)-3-[4-(6,7-dimethoxy-quinol...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4ccc(F)c(F)c4)cc3)c2cc1OC Show InChI InChI=1S/C24H19F2N3O4/c1-31-22-12-17-20(13-23(22)32-2)27-10-9-21(17)33-16-6-3-14(4-7-16)28-24(30)29-15-5-8-18(25)19(26)11-15/h3-13H,1-2H3,(H2,28,29,30) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co. Ltd.
Curated by ChEMBL
| Assay Description Inhibition of vascular endothelial growth factor receptor 2 |
J Med Chem 48: 1359-66 (2005)
Article DOI: 10.1021/jm030427r BindingDB Entry DOI: 10.7270/Q23J3CG1 |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50162162
(1-[4-(6,7-Dimethoxy-quinolin-4-yloxy)-phenyl]-3-(3...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4cccc(F)c4)cc3)c2cc1OC Show InChI InChI=1S/C24H20FN3O4/c1-30-22-13-19-20(14-23(22)31-2)26-11-10-21(19)32-18-8-6-16(7-9-18)27-24(29)28-17-5-3-4-15(25)12-17/h3-14H,1-2H3,(H2,27,28,29) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co. Ltd.
Curated by ChEMBL
| Assay Description Inhibition of vascular endothelial growth factor receptor 2 |
J Med Chem 48: 1359-66 (2005)
Article DOI: 10.1021/jm030427r BindingDB Entry DOI: 10.7270/Q23J3CG1 |
More data for this Ligand-Target Pair | |
Protein kinase C zeta type
(Homo sapiens (Human)) | BDBM50542126
(CHEMBL4642166)Show SMILES Nc1ccc(cc1)-c1cc(N[C@H]2CCCCNC2)c2ccncc2c1 |r| Show InChI InChI=1S/C21H24N4/c22-18-6-4-15(5-7-18)16-11-17-13-24-10-8-20(17)21(12-16)25-19-3-1-2-9-23-14-19/h4-8,10-13,19,23,25H,1-3,9,14,22H2/t19-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Asahi Kasei Pharma Corporation
Curated by ChEMBL
| Assay Description Inhibition of recombinant human PKCzeta using biotin-KKKKRFSFKKSFK substrate and ATP incubated for 30 mins by TR-FRET method |
J Med Chem 63: 7143-7162 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00449 BindingDB Entry DOI: 10.7270/Q24T6NWX |
More data for this Ligand-Target Pair | |
Protein kinase C zeta type
(Homo sapiens (Human)) | BDBM50542129
(CHEMBL4637452)Show SMILES Nc1cc(F)c(cc1F)-c1cc(N[C@H]2CCCCNC2)c2ccncc2c1 |r| Show InChI InChI=1S/C21H22F2N4/c22-18-10-20(24)19(23)9-17(18)13-7-14-11-26-6-4-16(14)21(8-13)27-15-3-1-2-5-25-12-15/h4,6-11,15,25,27H,1-3,5,12,24H2/t15-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Asahi Kasei Pharma Corporation
Curated by ChEMBL
| Assay Description Inhibition of recombinant human PKCzeta using biotin-KKKKRFSFKKSFK substrate and ATP incubated for 30 mins by TR-FRET method |
J Med Chem 63: 7143-7162 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00449 BindingDB Entry DOI: 10.7270/Q24T6NWX |
More data for this Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha
(Homo sapiens (Human)) | BDBM50162156
(1-(2,3-Difluoro-phenyl)-3-[4-(6,7-dimethoxy-quinol...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4cccc(F)c4F)cc3)c2cc1OC Show InChI InChI=1S/C24H19F2N3O4/c1-31-21-12-16-19(13-22(21)32-2)27-11-10-20(16)33-15-8-6-14(7-9-15)28-24(30)29-18-5-3-4-17(25)23(18)26/h3-13H,1-2H3,(H2,28,29,30) | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co. Ltd.
Curated by ChEMBL
| Assay Description Inhibition of platelet-derived growth factor receptor alpha |
J Med Chem 48: 1359-66 (2005)
Article DOI: 10.1021/jm030427r BindingDB Entry DOI: 10.7270/Q23J3CG1 |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50162171
(1-(3-Chloro-phenyl)-3-[4-(6,7-dimethoxy-quinolin-4...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4cccc(Cl)c4)cc3)c2cc1OC Show InChI InChI=1S/C24H20ClN3O4/c1-30-22-13-19-20(14-23(22)31-2)26-11-10-21(19)32-18-8-6-16(7-9-18)27-24(29)28-17-5-3-4-15(25)12-17/h3-14H,1-2H3,(H2,27,28,29) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 1.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co. Ltd.
Curated by ChEMBL
| Assay Description Inhibition of vascular endothelial growth factor receptor 2 |
J Med Chem 48: 1359-66 (2005)
Article DOI: 10.1021/jm030427r BindingDB Entry DOI: 10.7270/Q23J3CG1 |
More data for this Ligand-Target Pair | |
cGMP-dependent 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50258930
(CHEMBL4102321)Show SMILES COC[C@@H](NC(=O)N1CC(=O)Nc2cc(OC)cnc12)c1ccc(OC(F)(F)F)cc1 |r| Show InChI InChI=1S/C19H19F3N4O5/c1-29-10-15(11-3-5-12(6-4-11)31-19(20,21)22)25-18(28)26-9-16(27)24-14-7-13(30-2)8-23-17(14)26/h3-8,15H,9-10H2,1-2H3,(H,24,27)(H,25,28)/t15-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
| Assay Description Inhibition of recombinant human FLAG-tagged PDE2A3 expressed in sf21 cells using [3H]cGMP as substrate by scintillation proximity assay |
J Med Chem 60: 7677-7702 (2017)
Article DOI: 10.1021/acs.jmedchem.7b00807 BindingDB Entry DOI: 10.7270/Q2P271JR |
More data for this Ligand-Target Pair | |
Angiotensin-converting enzyme
(Homo sapiens (Human)) | BDBM21642
((2S)-1-[(2S)-2-methyl-3-sulfanylpropanoyl]pyrrolid...)Show InChI InChI=1S/C9H15NO3S/c1-6(5-14)8(11)10-4-2-3-7(10)9(12)13/h6-7,14H,2-5H2,1H3,(H,12,13)/t6-,7+/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem
Patents
Similars
| DrugBank PDB Article PubMed
| n/a | n/a | 1.60 | n/a | n/a | n/a | n/a | n/a | n/a |
RIKEN Center for Sustainable Resource Science
Curated by ChEMBL
| Assay Description Inhibition of ACE (unknown origin) using 3-Hydroxybutylyl-Gly-Gly-Gly substrate assessed as reduction in 3-Hyroxybutylic acid generation incubated fo... |
J Nat Prod 78: 1179-83 (2015)
Article DOI: 10.1021/acs.jnatprod.5b00092 BindingDB Entry DOI: 10.7270/Q28W3G2W |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50162163
(1-(3,5-Difluoro-phenyl)-3-[4-(6,7-dimethoxy-quinol...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4cc(F)cc(F)c4)cc3)c2cc1OC Show InChI InChI=1S/C24H19F2N3O4/c1-31-22-12-19-20(13-23(22)32-2)27-8-7-21(19)33-18-5-3-16(4-6-18)28-24(30)29-17-10-14(25)9-15(26)11-17/h3-13H,1-2H3,(H2,28,29,30) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co. Ltd.
Curated by ChEMBL
| Assay Description Inhibition of vascular endothelial growth factor receptor 2 |
J Med Chem 48: 1359-66 (2005)
Article DOI: 10.1021/jm030427r BindingDB Entry DOI: 10.7270/Q23J3CG1 |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50162170
(1-(2,6-Difluoro-phenyl)-3-[4-(6,7-dimethoxy-quinol...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4c(F)cccc4F)cc3)c2cc1OC Show InChI InChI=1S/C24H19F2N3O4/c1-31-21-12-16-19(13-22(21)32-2)27-11-10-20(16)33-15-8-6-14(7-9-15)28-24(30)29-23-17(25)4-3-5-18(23)26/h3-13H,1-2H3,(H2,28,29,30) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co. Ltd.
Curated by ChEMBL
| Assay Description Inhibition of vascular endothelial growth factor receptor 2 |
J Med Chem 48: 1359-66 (2005)
Article DOI: 10.1021/jm030427r BindingDB Entry DOI: 10.7270/Q23J3CG1 |
More data for this Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha
(Homo sapiens (Human)) | BDBM50162145
(1-[4-(6,7-Dimethoxy-quinolin-4-yloxy)-phenyl]-3-(3...)Show SMILES COc1cccc(NC(=O)Nc2ccc(Oc3ccnc4cc(OC)c(OC)cc34)cc2)c1 Show InChI InChI=1S/C25H23N3O5/c1-30-19-6-4-5-17(13-19)28-25(29)27-16-7-9-18(10-8-16)33-22-11-12-26-21-15-24(32-3)23(31-2)14-20(21)22/h4-15H,1-3H3,(H2,27,28,29) | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co. Ltd.
Curated by ChEMBL
| Assay Description Inhibition of platelet-derived growth factor receptor alpha |
J Med Chem 48: 1359-66 (2005)
Article DOI: 10.1021/jm030427r BindingDB Entry DOI: 10.7270/Q23J3CG1 |
More data for this Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha
(Homo sapiens (Human)) | BDBM50162152
(1-[4-(6,7-Dimethoxy-quinolin-4-yloxy)-phenyl]-3-(4...)Show SMILES COc1ccc(NC(=O)Nc2ccc(Oc3ccnc4cc(OC)c(OC)cc34)cc2)cc1 Show InChI InChI=1S/C25H23N3O5/c1-30-18-8-4-16(5-9-18)27-25(29)28-17-6-10-19(11-7-17)33-22-12-13-26-21-15-24(32-3)23(31-2)14-20(21)22/h4-15H,1-3H3,(H2,27,28,29) | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co. Ltd.
Curated by ChEMBL
| Assay Description Inhibition of platelet-derived growth factor receptor alpha |
J Med Chem 48: 1359-66 (2005)
Article DOI: 10.1021/jm030427r BindingDB Entry DOI: 10.7270/Q23J3CG1 |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50162157
(1-[4-(6,7-Dimethoxy-quinazolin-4-yloxy)-phenyl]-3-...)Show SMILES COc1ccc(NC(=O)Nc2ccc(Oc3ncnc4cc(OC)c(OC)cc34)cc2)cc1 Show InChI InChI=1S/C24H22N4O5/c1-30-17-8-4-15(5-9-17)27-24(29)28-16-6-10-18(11-7-16)33-23-19-12-21(31-2)22(32-3)13-20(19)25-14-26-23/h4-14H,1-3H3,(H2,27,28,29) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co. Ltd.
Curated by ChEMBL
| Assay Description Inhibition of vascular endothelial growth factor receptor 2 |
J Med Chem 48: 1359-66 (2005)
Article DOI: 10.1021/jm030427r BindingDB Entry DOI: 10.7270/Q23J3CG1 |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50162150
(1-[4-(6,7-Dimethoxy-quinolin-4-yloxy)-phenyl]-3-o-...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4ccccc4C)cc3)c2cc1OC Show InChI InChI=1S/C25H23N3O4/c1-16-6-4-5-7-20(16)28-25(29)27-17-8-10-18(11-9-17)32-22-12-13-26-21-15-24(31-3)23(30-2)14-19(21)22/h4-15H,1-3H3,(H2,27,28,29) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co. Ltd.
Curated by ChEMBL
| Assay Description Inhibition of vascular endothelial growth factor receptor 2 |
J Med Chem 48: 1359-66 (2005)
Article DOI: 10.1021/jm030427r BindingDB Entry DOI: 10.7270/Q23J3CG1 |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50162139
(1-[3-Chloro-4-(6,7-dimethoxy-quinolin-4-yloxy)-phe...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4ccc(F)cc4F)cc3Cl)c2cc1OC Show InChI InChI=1S/C24H18ClF2N3O4/c1-32-22-11-15-19(12-23(22)33-2)28-8-7-20(15)34-21-6-4-14(10-16(21)25)29-24(31)30-18-5-3-13(26)9-17(18)27/h3-12H,1-2H3,(H2,29,30,31) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co. Ltd.
Curated by ChEMBL
| Assay Description Inhibition of vascular endothelial growth factor receptor 2 |
J Med Chem 48: 1359-66 (2005)
Article DOI: 10.1021/jm030427r BindingDB Entry DOI: 10.7270/Q23J3CG1 |
More data for this Ligand-Target Pair | |
cGMP-dependent 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50258926
(CHEMBL4064402)Show SMILES COCC(NC(=O)N1CC(=O)Nc2cc(OC)cnc12)c1ccc(OC(F)(F)F)cc1 Show InChI InChI=1S/C19H19F3N4O5/c1-29-10-15(11-3-5-12(6-4-11)31-19(20,21)22)25-18(28)26-9-16(27)24-14-7-13(30-2)8-23-17(14)26/h3-8,15H,9-10H2,1-2H3,(H,24,27)(H,25,28) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
| Assay Description Inhibition of recombinant human FLAG-tagged PDE2A3 expressed in sf21 cells using [3H]cGMP as substrate by scintillation proximity assay |
J Med Chem 60: 7677-7702 (2017)
Article DOI: 10.1021/acs.jmedchem.7b00807 BindingDB Entry DOI: 10.7270/Q2P271JR |
More data for this Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha
(Homo sapiens (Human)) | BDBM50162166
(1-[2-Chloro-4-(6,7-dimethoxy-quinolin-4-yloxy)-phe...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4ccc(F)cc4F)c(Cl)c3)c2cc1OC Show InChI InChI=1S/C24H18ClF2N3O4/c1-32-22-11-15-20(12-23(22)33-2)28-8-7-21(15)34-14-4-6-18(16(25)10-14)29-24(31)30-19-5-3-13(26)9-17(19)27/h3-12H,1-2H3,(H2,29,30,31) | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | <3 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co. Ltd.
Curated by ChEMBL
| Assay Description Inhibition of platelet-derived growth factor receptor alpha in cell-intact assay |
J Med Chem 48: 1359-66 (2005)
Article DOI: 10.1021/jm030427r BindingDB Entry DOI: 10.7270/Q23J3CG1 |
More data for this Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha
(Homo sapiens (Human)) | BDBM50162143
(1-[4-(6,7-Dimethoxy-quinolin-4-yloxy)-phenyl]-3-m-...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4cccc(C)c4)cc3)c2cc1OC Show InChI InChI=1S/C25H23N3O4/c1-16-5-4-6-18(13-16)28-25(29)27-17-7-9-19(10-8-17)32-22-11-12-26-21-15-24(31-3)23(30-2)14-20(21)22/h4-15H,1-3H3,(H2,27,28,29) | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co. Ltd.
Curated by ChEMBL
| Assay Description Inhibition of platelet-derived growth factor receptor alpha |
J Med Chem 48: 1359-66 (2005)
Article DOI: 10.1021/jm030427r BindingDB Entry DOI: 10.7270/Q23J3CG1 |
More data for this Ligand-Target Pair | |
Protein kinase C zeta type
(Homo sapiens (Human)) | BDBM50542134
(CHEMBL4647780)Show SMILES Nc1cc(F)c(cn1)-c1cc(N[C@H]2CCCCNC2)c2ccncc2c1 |r| Show InChI InChI=1S/C20H22FN5/c21-18-9-20(22)25-12-17(18)13-7-14-10-24-6-4-16(14)19(8-13)26-15-3-1-2-5-23-11-15/h4,6-10,12,15,23,26H,1-3,5,11H2,(H2,22,25)/t15-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 3.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Asahi Kasei Pharma Corporation
Curated by ChEMBL
| Assay Description Inhibition of recombinant human PKCzeta using biotin-KKKKRFSFKKSFK substrate and ATP incubated for 30 mins by TR-FRET method |
J Med Chem 63: 7143-7162 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00449 BindingDB Entry DOI: 10.7270/Q24T6NWX |
More data for this Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha
(Homo sapiens (Human)) | BDBM50162148
(1-(2,4-Difluoro-phenyl)-3-[4-(6,7-dimethoxy-quinol...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4ccc(F)cc4F)cc3)c2cc1OC Show InChI InChI=1S/C24H19F2N3O4/c1-31-22-12-17-20(13-23(22)32-2)27-10-9-21(17)33-16-6-4-15(5-7-16)28-24(30)29-19-8-3-14(25)11-18(19)26/h3-13H,1-2H3,(H2,28,29,30) | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co. Ltd.
Curated by ChEMBL
| Assay Description Inhibition of platelet-derived growth factor receptor alpha |
J Med Chem 48: 1359-66 (2005)
Article DOI: 10.1021/jm030427r BindingDB Entry DOI: 10.7270/Q23J3CG1 |
More data for this Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha
(Homo sapiens (Human)) | BDBM50162170
(1-(2,6-Difluoro-phenyl)-3-[4-(6,7-dimethoxy-quinol...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4c(F)cccc4F)cc3)c2cc1OC Show InChI InChI=1S/C24H19F2N3O4/c1-31-21-12-16-19(13-22(21)32-2)27-11-10-20(16)33-15-8-6-14(7-9-15)28-24(30)29-23-17(25)4-3-5-18(23)26/h3-13H,1-2H3,(H2,28,29,30) | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co. Ltd.
Curated by ChEMBL
| Assay Description Inhibition of platelet-derived growth factor receptor alpha |
J Med Chem 48: 1359-66 (2005)
Article DOI: 10.1021/jm030427r BindingDB Entry DOI: 10.7270/Q23J3CG1 |
More data for this Ligand-Target Pair | |