Compile Data Set for Download or QSAR

Found 359 hits with Last Name = 'lombardi borgia' and Initial = 'a'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM149692 (US8975267, 34) Show SMILES CSc1ncc2ccc3c(cn([C@@H]4CC[C@H](N)CC4)c3c2n1)C(N)=O |wU:15.15,12.11,(6.59,1.87,;5.05,1.92,;4.24,.61,;4.97,-.75,;4.16,-2.06,;2.62,-2.01,;1.81,-3.32,;.27,-3.27,;-.46,-1.92,;-1.96,-1.55,;-2.07,-.01,;-.64,.57,;-.28,2.07,;1.2,2.49,;1.57,3.99,;.46,5.06,;.82,6.55,;-1.02,4.63,;-1.39,3.13,;.35,-.61,;1.89,-.65,;2.7,.65,;-3.13,-2.54,;-2.86,-4.06,;-4.58,-2.02,)| Show InChI InChI=1S/C18H21N5OS/c1-25-18-21-8-10-2-7-13-14(17(20)24)9-23(16(13)15(10)22-18)12-5-3-11(19)4-6-12/h2,7-9,11-12H,3-6,19H2,1H3,(H2,20,24)/t11-,12+	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.800	n/a	n/a	n/a	n/a	3.0	n/a
Nerviano Medical Sciences S.r.l. US Patent					Assay Description Specific peptide or protein substrates are trans-phosphorylated by their specific ser-thr or tyr kinase in the presence of ATP traced with 33P-gamma-...				US Patent US8975267 (2015) BindingDB Entry DOI: 10.7270/Q29C6W41
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-2 (Homo sapiens (Human))	BDBM149692 (US8975267, 34) Show SMILES CSc1ncc2ccc3c(cn([C@@H]4CC[C@H](N)CC4)c3c2n1)C(N)=O |wU:15.15,12.11,(6.59,1.87,;5.05,1.92,;4.24,.61,;4.97,-.75,;4.16,-2.06,;2.62,-2.01,;1.81,-3.32,;.27,-3.27,;-.46,-1.92,;-1.96,-1.55,;-2.07,-.01,;-.64,.57,;-.28,2.07,;1.2,2.49,;1.57,3.99,;.46,5.06,;.82,6.55,;-1.02,4.63,;-1.39,3.13,;.35,-.61,;1.89,-.65,;2.7,.65,;-3.13,-2.54,;-2.86,-4.06,;-4.58,-2.02,)| Show InChI InChI=1S/C18H21N5OS/c1-25-18-21-8-10-2-7-13-14(17(20)24)9-23(16(13)15(10)22-18)12-5-3-11(19)4-6-12/h2,7-9,11-12H,3-6,19H2,1H3,(H2,20,24)/t11-,12+	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	7.5	n/a
Nerviano Medical Sciences S.r.l. US Patent					Assay Description The buffer for PIM-2 assay was composed of HEPES 50 mM, at pH 7.5, with 1 mM MgCl2, 1 mM DTT, 3 microM Na3VO4, and 0.2 mg/mL BSAFull-length human PIM...				US Patent US8975267 (2015) BindingDB Entry DOI: 10.7270/Q29C6W41
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM149689 (US8975267, 30) Show SMILES CSc1ncc2ccc3c(C(N)=O)c(C)n(C(C)C)c3c2n1 Show InChI InChI=1S/C16H18N4OS/c1-8(2)20-9(3)12(15(17)21)11-6-5-10-7-18-16(22-4)19-13(10)14(11)20/h5-8H,1-4H3,(H2,17,21)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	3.0	n/a
Nerviano Medical Sciences S.r.l. US Patent					Assay Description Specific peptide or protein substrates are trans-phosphorylated by their specific ser-thr or tyr kinase in the presence of ATP traced with 33P-gamma-...				US Patent US8975267 (2015) BindingDB Entry DOI: 10.7270/Q29C6W41
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM149691 (US8975267, 33) Show SMILES CSc1ncc2CCc3c(cn([C@@H]4CC[C@H](N)CC4)c3-c2n1)C(N)=O |wU:15.15,12.11,(6.59,1.87,;5.05,1.92,;4.24,.61,;4.97,-.75,;4.16,-2.06,;2.62,-2.01,;1.81,-3.32,;.27,-3.27,;-.46,-1.92,;-1.96,-1.55,;-2.07,-.01,;-.64,.57,;-.28,2.07,;1.2,2.49,;1.57,3.99,;.46,5.06,;.82,6.55,;-1.02,4.63,;-1.39,3.13,;.35,-.61,;1.89,-.65,;2.7,.65,;-3.13,-2.54,;-2.86,-4.06,;-4.58,-2.02,)| Show InChI InChI=1S/C18H23N5OS/c1-25-18-21-8-10-2-7-13-14(17(20)24)9-23(16(13)15(10)22-18)12-5-3-11(19)4-6-12/h8-9,11-12H,2-7,19H2,1H3,(H2,20,24)/t11-,12+	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	5	n/a	n/a	n/a	n/a	3.0	n/a
Nerviano Medical Sciences S.r.l. US Patent					Assay Description Specific peptide or protein substrates are trans-phosphorylated by their specific ser-thr or tyr kinase in the presence of ATP traced with 33P-gamma-...				US Patent US8975267 (2015) BindingDB Entry DOI: 10.7270/Q29C6W41
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-2 (Homo sapiens (Human))	BDBM149691 (US8975267, 33) Show SMILES CSc1ncc2CCc3c(cn([C@@H]4CC[C@H](N)CC4)c3-c2n1)C(N)=O |wU:15.15,12.11,(6.59,1.87,;5.05,1.92,;4.24,.61,;4.97,-.75,;4.16,-2.06,;2.62,-2.01,;1.81,-3.32,;.27,-3.27,;-.46,-1.92,;-1.96,-1.55,;-2.07,-.01,;-.64,.57,;-.28,2.07,;1.2,2.49,;1.57,3.99,;.46,5.06,;.82,6.55,;-1.02,4.63,;-1.39,3.13,;.35,-.61,;1.89,-.65,;2.7,.65,;-3.13,-2.54,;-2.86,-4.06,;-4.58,-2.02,)| Show InChI InChI=1S/C18H23N5OS/c1-25-18-21-8-10-2-7-13-14(17(20)24)9-23(16(13)15(10)22-18)12-5-3-11(19)4-6-12/h8-9,11-12H,2-7,19H2,1H3,(H2,20,24)/t11-,12+	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	7	n/a	n/a	n/a	n/a	7.5	n/a
Nerviano Medical Sciences S.r.l. US Patent					Assay Description The buffer for PIM-2 assay was composed of HEPES 50 mM, at pH 7.5, with 1 mM MgCl2, 1 mM DTT, 3 microM Na3VO4, and 0.2 mg/mL BSAFull-length human PIM...				US Patent US8975267 (2015) BindingDB Entry DOI: 10.7270/Q29C6W41
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM149693 (US8975267, 35) Show SMILES CSc1ncc2ccc3c(cn(C4CCNCC4)c3c2n1)C(N)=O Show InChI InChI=1S/C17H19N5OS/c1-24-17-20-8-10-2-3-12-13(16(18)23)9-22(15(12)14(10)21-17)11-4-6-19-7-5-11/h2-3,8-9,11,19H,4-7H2,1H3,(H2,18,23)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	7	n/a	n/a	n/a	n/a	3.0	n/a
Nerviano Medical Sciences S.r.l. US Patent					Assay Description Specific peptide or protein substrates are trans-phosphorylated by their specific ser-thr or tyr kinase in the presence of ATP traced with 33P-gamma-...				US Patent US8975267 (2015) BindingDB Entry DOI: 10.7270/Q29C6W41
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-2 (Homo sapiens (Human))	BDBM149689 (US8975267, 30) Show SMILES CSc1ncc2ccc3c(C(N)=O)c(C)n(C(C)C)c3c2n1 Show InChI InChI=1S/C16H18N4OS/c1-8(2)20-9(3)12(15(17)21)11-6-5-10-7-18-16(22-4)19-13(10)14(11)20/h5-8H,1-4H3,(H2,17,21)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	12	n/a	n/a	n/a	n/a	7.5	n/a
Nerviano Medical Sciences S.r.l. US Patent					Assay Description The buffer for PIM-2 assay was composed of HEPES 50 mM, at pH 7.5, with 1 mM MgCl2, 1 mM DTT, 3 microM Na3VO4, and 0.2 mg/mL BSAFull-length human PIM...				US Patent US8975267 (2015) BindingDB Entry DOI: 10.7270/Q29C6W41
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM149694 (US8975267, 36) Show SMILES CSc1ncc2ccc3c(c[nH]c3c2n1)C(N)=O Show InChI InChI=1S/C12H10N4OS/c1-18-12-15-4-6-2-3-7-8(11(13)17)5-14-10(7)9(6)16-12/h2-5,14H,1H3,(H2,13,17)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	13	n/a	n/a	n/a	n/a	3.0	n/a
Nerviano Medical Sciences S.r.l. US Patent					Assay Description Specific peptide or protein substrates are trans-phosphorylated by their specific ser-thr or tyr kinase in the presence of ATP traced with 33P-gamma-...				US Patent US8975267 (2015) BindingDB Entry DOI: 10.7270/Q29C6W41
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM149686 (US8975267, 22) Show SMILES CSc1ncc2CCc3c(cn(C(C)C)c3-c2n1)C(N)=O Show InChI InChI=1S/C15H18N4OS/c1-8(2)19-7-11(14(16)20)10-5-4-9-6-17-15(21-3)18-12(9)13(10)19/h6-8H,4-5H2,1-3H3,(H2,16,20)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	16	n/a	n/a	n/a	n/a	3.0	n/a
Nerviano Medical Sciences S.r.l. US Patent					Assay Description Specific peptide or protein substrates are trans-phosphorylated by their specific ser-thr or tyr kinase in the presence of ATP traced with 33P-gamma-...				US Patent US8975267 (2015) BindingDB Entry DOI: 10.7270/Q29C6W41
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-2 (Homo sapiens (Human))	BDBM149693 (US8975267, 35) Show SMILES CSc1ncc2ccc3c(cn(C4CCNCC4)c3c2n1)C(N)=O Show InChI InChI=1S/C17H19N5OS/c1-24-17-20-8-10-2-3-12-13(16(18)23)9-22(15(12)14(10)21-17)11-4-6-19-7-5-11/h2-3,8-9,11,19H,4-7H2,1H3,(H2,18,23)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	23	n/a	n/a	n/a	n/a	7.5	n/a
Nerviano Medical Sciences S.r.l. US Patent					Assay Description The buffer for PIM-2 assay was composed of HEPES 50 mM, at pH 7.5, with 1 mM MgCl2, 1 mM DTT, 3 microM Na3VO4, and 0.2 mg/mL BSAFull-length human PIM...				US Patent US8975267 (2015) BindingDB Entry DOI: 10.7270/Q29C6W41
					More data for this Ligand-Target Pair
Dual specificity protein kinase TTK (Homo sapiens (Human))	BDBM149685 (US8975267, 7) Show SMILES COc1cc(ccc1Nc1ncc2CCc3c(C(N)=O)c(C)n(C)c3-c2n1)N1CCN(C)CC1 Show InChI InChI=1S/C25H31N7O2/c1-15-21(24(26)33)18-7-5-16-14-27-25(29-22(16)23(18)31(15)3)28-19-8-6-17(13-20(19)34-4)32-11-9-30(2)10-12-32/h6,8,13-14H,5,7,9-12H2,1-4H3,(H2,26,33)(H,27,28,29)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	23	n/a	n/a	n/a	n/a	3.0	n/a
Nerviano Medical Sciences S.r.l. US Patent					Assay Description Specific peptide or protein substrates are trans-phosphorylated by their specific ser-thr or tyr kinase in the presence of ATP traced with 33P-gamma-...				US Patent US8975267 (2015) BindingDB Entry DOI: 10.7270/Q29C6W41
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-2 (Homo sapiens (Human))	BDBM149686 (US8975267, 22) Show SMILES CSc1ncc2CCc3c(cn(C(C)C)c3-c2n1)C(N)=O Show InChI InChI=1S/C15H18N4OS/c1-8(2)19-7-11(14(16)20)10-5-4-9-6-17-15(21-3)18-12(9)13(10)19/h6-8H,4-5H2,1-3H3,(H2,16,20)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	24	n/a	n/a	n/a	n/a	7.5	n/a
Nerviano Medical Sciences S.r.l. US Patent					Assay Description The buffer for PIM-2 assay was composed of HEPES 50 mM, at pH 7.5, with 1 mM MgCl2, 1 mM DTT, 3 microM Na3VO4, and 0.2 mg/mL BSAFull-length human PIM...				US Patent US8975267 (2015) BindingDB Entry DOI: 10.7270/Q29C6W41
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM149695 (US8975267, 38) Show SMILES CSc1ncc2ccc3c(cn(CC(C)(C)CN)c3c2n1)C(N)=O Show InChI InChI=1S/C17H21N5OS/c1-17(2,8-18)9-22-7-12(15(19)23)11-5-4-10-6-20-16(24-3)21-13(10)14(11)22/h4-7H,8-9,18H2,1-3H3,(H2,19,23)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	24	n/a	n/a	n/a	n/a	3.0	n/a
Nerviano Medical Sciences S.r.l. US Patent					Assay Description Specific peptide or protein substrates are trans-phosphorylated by their specific ser-thr or tyr kinase in the presence of ATP traced with 33P-gamma-...				US Patent US8975267 (2015) BindingDB Entry DOI: 10.7270/Q29C6W41
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-2 (Homo sapiens (Human))	BDBM149695 (US8975267, 38) Show SMILES CSc1ncc2ccc3c(cn(CC(C)(C)CN)c3c2n1)C(N)=O Show InChI InChI=1S/C17H21N5OS/c1-17(2,8-18)9-22-7-12(15(19)23)11-5-4-10-6-20-16(24-3)21-13(10)14(11)22/h4-7H,8-9,18H2,1-3H3,(H2,19,23)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	34	n/a	n/a	n/a	n/a	7.5	n/a
Nerviano Medical Sciences S.r.l. US Patent					Assay Description The buffer for PIM-2 assay was composed of HEPES 50 mM, at pH 7.5, with 1 mM MgCl2, 1 mM DTT, 3 microM Na3VO4, and 0.2 mg/mL BSAFull-length human PIM...				US Patent US8975267 (2015) BindingDB Entry DOI: 10.7270/Q29C6W41
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-2 (Homo sapiens (Human))	BDBM149694 (US8975267, 36) Show SMILES CSc1ncc2ccc3c(c[nH]c3c2n1)C(N)=O Show InChI InChI=1S/C12H10N4OS/c1-18-12-15-4-6-2-3-7-8(11(13)17)5-14-10(7)9(6)16-12/h2-5,14H,1H3,(H2,13,17)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	46	n/a	n/a	n/a	n/a	7.5	n/a
Nerviano Medical Sciences S.r.l. US Patent					Assay Description The buffer for PIM-2 assay was composed of HEPES 50 mM, at pH 7.5, with 1 mM MgCl2, 1 mM DTT, 3 microM Na3VO4, and 0.2 mg/mL BSAFull-length human PIM...				US Patent US8975267 (2015) BindingDB Entry DOI: 10.7270/Q29C6W41
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM239026 (US10028934, Compound 40 | US10478423, Cpd. 40 | US...) Show SMILES COc1ccc(COCCOc2ccc3c(NC(=O)c4ccc(cc4)N4CCN(C)CC4)n[nH]c3c2)cc1 Show InChI InChI=1S/C29H33N5O4/c1-33-13-15-34(16-14-33)23-7-5-22(6-8-23)29(35)30-28-26-12-11-25(19-27(26)31-32-28)38-18-17-37-20-21-3-9-24(36-2)10-4-21/h3-12,19H,13-18,20H2,1-2H3,(H2,30,31,32,35)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
NERVIANO MEDICAL SCIENCES S.R.L. US Patent					Assay Description i. Enzyme—The assay was performed using FLT3 cytoplasmic domain product and purified in house as GST fused protein. The FLT3 protein (1 microM) was p...				US Patent US10478423 (2019) BindingDB Entry DOI: 10.7270/Q2WQ065N
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM239033 (US10028934, Compound 19 | US10478423, Cpd. 19 | US...) Show SMILES CN1CCC(CC1)Nc1ccc(cc1)C(=O)Nc1n[nH]c2cc(OCCOCc3ccccc3)ccc12 Show InChI InChI=1S/C29H33N5O3/c1-34-15-13-24(14-16-34)30-23-9-7-22(8-10-23)29(35)31-28-26-12-11-25(19-27(26)32-33-28)37-18-17-36-20-21-5-3-2-4-6-21/h2-12,19,24,30H,13-18,20H2,1H3,(H2,31,32,33,35)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	7.9	n/a
NERVIANO MEDICAL SCIENCES S.R.L. US Patent					Assay Description i. Enzyme The assay was performed using FLT3 cytoplasmic domain product and purified in house as GST fused protein. The FLT3 protein (1 microM) was p...				US Patent US10028934 (2018) BindingDB Entry DOI: 10.7270/Q27D2X53
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM239022 (US10028934, Compound 33 | US10478423, Cpd. 33 | US...) Show SMILES CN1CCN(CC1)c1ccc(cc1)C(=O)Nc1n[nH]c2cc(OCCOCc3ccc(cc3)C(F)(F)F)ccc12 Show InChI InChI=1S/C29H30F3N5O3/c1-36-12-14-37(15-13-36)23-8-4-21(5-9-23)28(38)33-27-25-11-10-24(18-26(25)34-35-27)40-17-16-39-19-20-2-6-22(7-3-20)29(30,31)32/h2-11,18H,12-17,19H2,1H3,(H2,33,34,35,38)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	50	n/a	n/a	n/a	n/a	7.9	n/a
NERVIANO MEDICAL SCIENCES S.R.L. US Patent					Assay Description i. Enzyme The assay has been performed using KIT cytoplasmic domain product and purified in house as GST fused protein. The KIT protein (4.5 microM) ...				US Patent US10028934 (2018) BindingDB Entry DOI: 10.7270/Q27D2X53
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM239017 (US10028934, Compound 11 | US10478423, Cpd. 11 | US...) Show SMILES CN1CCN(CC1)c1ccc(cc1)C(=O)Nc1n[nH]c2cc(OCCOCc3ccccc3)ccc12 Show InChI InChI=1S/C28H31N5O3/c1-32-13-15-33(16-14-32)23-9-7-22(8-10-23)28(34)29-27-25-12-11-24(19-26(25)30-31-27)36-18-17-35-20-21-5-3-2-4-6-21/h2-12,19H,13-18,20H2,1H3,(H2,29,30,31,34)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
NERVIANO MEDICAL SCIENCES S.R.L. US Patent					Assay Description i. Enzyme The assay was performed using FLT3 cytoplasmic domain product and purified in house as GST fused protein. The FLT3 protein (1 microM) was p...				US Patent US9597317 (2017) BindingDB Entry DOI: 10.7270/Q2N58PDX
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM239022 (US10028934, Compound 33 | US10478423, Cpd. 33 | US...) Show SMILES CN1CCN(CC1)c1ccc(cc1)C(=O)Nc1n[nH]c2cc(OCCOCc3ccc(cc3)C(F)(F)F)ccc12 Show InChI InChI=1S/C29H30F3N5O3/c1-36-12-14-37(15-13-36)23-8-4-21(5-9-23)28(38)33-27-25-11-10-24(18-26(25)34-35-27)40-17-16-39-19-20-2-6-22(7-3-20)29(30,31)32/h2-11,18H,12-17,19H2,1H3,(H2,33,34,35,38)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
NERVIANO MEDICAL SCIENCES S.R.L. US Patent					Assay Description i. Enzyme The assay was performed using FLT3 cytoplasmic domain product and purified in house as GST fused protein. The FLT3 protein (1 microM) was p...				US Patent US9597317 (2017) BindingDB Entry DOI: 10.7270/Q2N58PDX
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM239043 (US10028934, Compound 20 | US10478423, Cpd. 20 | US...) Show SMILES O=C(Nc1n[nH]c2cc(OCCOCc3ccccc3)ccc12)c1ccc(cc1)N1CCNCC1 Show InChI InChI=1S/C27H29N5O3/c33-27(21-6-8-22(9-7-21)32-14-12-28-13-15-32)29-26-24-11-10-23(18-25(24)30-31-26)35-17-16-34-19-20-4-2-1-3-5-20/h1-11,18,28H,12-17,19H2,(H2,29,30,31,33)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	7.9	n/a
NERVIANO MEDICAL SCIENCES S.R.L. US Patent					Assay Description i. Enzyme The assay was performed using FLT3 cytoplasmic domain product and purified in house as GST fused protein. The FLT3 protein (1 microM) was p...				US Patent US10028934 (2018) BindingDB Entry DOI: 10.7270/Q27D2X53
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM239034 (US10028934, Compound 23 | US10478423, Cpd. 23 | US...) Show SMILES CN(C1CCN(C)CC1)c1ccc(cc1)C(=O)Nc1n[nH]c2cc(OCCOCc3ccccc3)ccc12 Show InChI InChI=1S/C30H35N5O3/c1-34-16-14-25(15-17-34)35(2)24-10-8-23(9-11-24)30(36)31-29-27-13-12-26(20-28(27)32-33-29)38-19-18-37-21-22-6-4-3-5-7-22/h3-13,20,25H,14-19,21H2,1-2H3,(H2,31,32,33,36)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	7.9	n/a
NERVIANO MEDICAL SCIENCES S.R.L. US Patent					Assay Description i. Enzyme The assay was performed using FLT3 cytoplasmic domain product and purified in house as GST fused protein. The FLT3 protein (1 microM) was p...				US Patent US10028934 (2018) BindingDB Entry DOI: 10.7270/Q27D2X53
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM239038 (US10028934, Compound 27 | US10478423, Cpd. 27 | US...) Show SMILES CN1CCC(CNc2ccc(cc2)C(=O)Nc2n[nH]c3cc(OCCOCc4ccccc4)ccc23)CC1 Show InChI InChI=1S/C30H35N5O3/c1-35-15-13-22(14-16-35)20-31-25-9-7-24(8-10-25)30(36)32-29-27-12-11-26(19-28(27)33-34-29)38-18-17-37-21-23-5-3-2-4-6-23/h2-12,19,22,31H,13-18,20-21H2,1H3,(H2,32,33,34,36)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	7.9	n/a
NERVIANO MEDICAL SCIENCES S.R.L. US Patent					Assay Description i. Enzyme The assay was performed using FLT3 cytoplasmic domain product and purified in house as GST fused protein. The FLT3 protein (1 microM) was p...				US Patent US10028934 (2018) BindingDB Entry DOI: 10.7270/Q27D2X53
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM239023 (US10028934, Compound 32 | US10478423, Cpd. 32 | US...) Show SMILES CN1CCN(CC1)c1ccc(cc1)C(=O)Nc1n[nH]c2cc(OCCOCc3ccc(F)cc3)ccc12 Show InChI InChI=1S/C28H30FN5O3/c1-33-12-14-34(15-13-33)23-8-4-21(5-9-23)28(35)30-27-25-11-10-24(18-26(25)31-32-27)37-17-16-36-19-20-2-6-22(29)7-3-20/h2-11,18H,12-17,19H2,1H3,(H2,30,31,32,35)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	7.9	n/a
NERVIANO MEDICAL SCIENCES S.R.L. US Patent					Assay Description i. Enzyme The assay was performed using FLT3 cytoplasmic domain product and purified in house as GST fused protein. The FLT3 protein (1 microM) was p...				US Patent US10028934 (2018) BindingDB Entry DOI: 10.7270/Q27D2X53
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM239023 (US10028934, Compound 32 | US10478423, Cpd. 32 | US...) Show SMILES CN1CCN(CC1)c1ccc(cc1)C(=O)Nc1n[nH]c2cc(OCCOCc3ccc(F)cc3)ccc12 Show InChI InChI=1S/C28H30FN5O3/c1-33-12-14-34(15-13-33)23-8-4-21(5-9-23)28(35)30-27-25-11-10-24(18-26(25)31-32-27)37-17-16-36-19-20-2-6-22(29)7-3-20/h2-11,18H,12-17,19H2,1H3,(H2,30,31,32,35)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	50	n/a	n/a	n/a	n/a	7.9	n/a
NERVIANO MEDICAL SCIENCES S.R.L. US Patent					Assay Description i. Enzyme The assay has been performed using KIT cytoplasmic domain product and purified in house as GST fused protein. The KIT protein (4.5 microM) ...				US Patent US10028934 (2018) BindingDB Entry DOI: 10.7270/Q27D2X53
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM239022 (US10028934, Compound 33 | US10478423, Cpd. 33 | US...) Show SMILES CN1CCN(CC1)c1ccc(cc1)C(=O)Nc1n[nH]c2cc(OCCOCc3ccc(cc3)C(F)(F)F)ccc12 Show InChI InChI=1S/C29H30F3N5O3/c1-36-12-14-37(15-13-36)23-8-4-21(5-9-23)28(38)33-27-25-11-10-24(18-26(25)34-35-27)40-17-16-39-19-20-2-6-22(7-3-20)29(30,31)32/h2-11,18H,12-17,19H2,1H3,(H2,33,34,35,38)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	7.9	n/a
NERVIANO MEDICAL SCIENCES S.R.L. US Patent					Assay Description i. Enzyme The assay was performed using FLT3 cytoplasmic domain product and purified in house as GST fused protein. The FLT3 protein (1 microM) was p...				US Patent US10028934 (2018) BindingDB Entry DOI: 10.7270/Q27D2X53
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM239012 (US10028934, Compound 10 | US10478423, Cpd. 10 | US...) Show SMILES CN1CCN(CC1)c1ccc(cc1)C(=O)Nc1n[nH]c2cc(OCCOc3ccccc3)ccc12 Show InChI InChI=1S/C27H29N5O3/c1-31-13-15-32(16-14-31)21-9-7-20(8-10-21)27(33)28-26-24-12-11-23(19-25(24)29-30-26)35-18-17-34-22-5-3-2-4-6-22/h2-12,19H,13-18H2,1H3,(H2,28,29,30,33)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
NERVIANO MEDICAL SCIENCES S.R.L. US Patent					Assay Description i. Enzyme The assay was performed using FLT3 cytoplasmic domain product and purified in house as GST fused protein. The FLT3 protein (1 microM) was p...				US Patent US9597317 (2017) BindingDB Entry DOI: 10.7270/Q2N58PDX
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM239040 (US10028934, Compound 14 | US10478423, Cpd. 14 | US...) Show SMILES C[N+]1([O-])CCN(CC1)c1ccc(cc1)C(=O)Nc1n[nH]c2cc(OCCOCc3ccccc3)ccc12 Show InChI InChI=1S/C28H31N5O4/c1-33(35)15-13-32(14-16-33)23-9-7-22(8-10-23)28(34)29-27-25-12-11-24(19-26(25)30-31-27)37-18-17-36-20-21-5-3-2-4-6-21/h2-12,19H,13-18,20H2,1H3,(H2,29,30,31,34)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
NERVIANO MEDICAL SCIENCES S.R.L. US Patent					Assay Description i. Enzyme The assay was performed using FLT3 cytoplasmic domain product and purified in house as GST fused protein. The FLT3 protein (1 microM) was p...				US Patent US9597317 (2017) BindingDB Entry DOI: 10.7270/Q2N58PDX
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM239029 (US10028934, Compound 15 | US10478423, Cpd. 15 | US...) Show SMILES CN(C)C1CCN(CC1)c1ccc(cc1)C(=O)Nc1n[nH]c2cc(OCCOCc3ccccc3)ccc12 Show InChI InChI=1S/C30H35N5O3/c1-34(2)24-14-16-35(17-15-24)25-10-8-23(9-11-25)30(36)31-29-27-13-12-26(20-28(27)32-33-29)38-19-18-37-21-22-6-4-3-5-7-22/h3-13,20,24H,14-19,21H2,1-2H3,(H2,31,32,33,36)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
NERVIANO MEDICAL SCIENCES S.R.L. US Patent					Assay Description i. Enzyme The assay was performed using FLT3 cytoplasmic domain product and purified in house as GST fused protein. The FLT3 protein (1 microM) was p...				US Patent US9597317 (2017) BindingDB Entry DOI: 10.7270/Q2N58PDX
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM239030 (US10028934, Compound 16 | US10478423, Cpd. 16 | US...) Show SMILES CN(C)CCN(C)c1ccc(cc1)C(=O)Nc1n[nH]c2cc(OCCOCc3ccccc3)ccc12 Show InChI InChI=1S/C28H33N5O3/c1-32(2)15-16-33(3)23-11-9-22(10-12-23)28(34)29-27-25-14-13-24(19-26(25)30-31-27)36-18-17-35-20-21-7-5-4-6-8-21/h4-14,19H,15-18,20H2,1-3H3,(H2,29,30,31,34)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
NERVIANO MEDICAL SCIENCES S.R.L. US Patent					Assay Description i. Enzyme The assay was performed using FLT3 cytoplasmic domain product and purified in house as GST fused protein. The FLT3 protein (1 microM) was p...				US Patent US9597317 (2017) BindingDB Entry DOI: 10.7270/Q2N58PDX
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM301791 (N-[6-(2-Benzyloxy-ethoxy)-1H-indazol-3-yl]-(1-meth...) Show SMILES CN1CCC(CC1)Nc1ccccc1C(=O)Nc1n[nH]c2cc(OCCOCc3ccccc3)ccc12 Show InChI InChI=1S/C29H33N5O3/c1-34-15-13-22(14-16-34)30-26-10-6-5-9-25(26)29(35)31-28-24-12-11-23(19-27(24)32-33-28)37-18-17-36-20-21-7-3-2-4-8-21/h2-12,19,22,30H,13-18,20H2,1H3,(H2,31,32,33,35)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
NERVIANO MEDICAL SCIENCES S.R.L. US Patent					Assay Description i. Enzyme The assay was performed using FLT3 cytoplasmic domain product and purified in house as GST fused protein. The FLT3 protein (1 microM) was p...				US Patent US9597317 (2017) BindingDB Entry DOI: 10.7270/Q2N58PDX
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM239043 (US10028934, Compound 20 | US10478423, Cpd. 20 | US...) Show SMILES O=C(Nc1n[nH]c2cc(OCCOCc3ccccc3)ccc12)c1ccc(cc1)N1CCNCC1 Show InChI InChI=1S/C27H29N5O3/c33-27(21-6-8-22(9-7-21)32-14-12-28-13-15-32)29-26-24-11-10-23(18-25(24)30-31-26)35-17-16-34-19-20-4-2-1-3-5-20/h1-11,18,28H,12-17,19H2,(H2,29,30,31,33)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
NERVIANO MEDICAL SCIENCES S.R.L. US Patent					Assay Description i. Enzyme The assay was performed using FLT3 cytoplasmic domain product and purified in house as GST fused protein. The FLT3 protein (1 microM) was p...				US Patent US9597317 (2017) BindingDB Entry DOI: 10.7270/Q2N58PDX
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM301795 (N-[6-(2-Benzyloxy-ethoxy)-1H-indazol-3-yl]-4-methy...) Show SMILES CN1CCC(CC1)c1c(C)ccc(C(=O)Nc2n[nH]c3cc(OCCOCc4ccccc4)ccc23)c1N Show InChI InChI=1S/C30H35N5O3/c1-20-8-10-25(28(31)27(20)22-12-14-35(2)15-13-22)30(36)32-29-24-11-9-23(18-26(24)33-34-29)38-17-16-37-19-21-6-4-3-5-7-21/h3-11,18,22H,12-17,19,31H2,1-2H3,(H2,32,33,34,36)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
NERVIANO MEDICAL SCIENCES S.R.L. US Patent					Assay Description i. Enzyme The assay was performed using FLT3 cytoplasmic domain product and purified in house as GST fused protein. The FLT3 protein (1 microM) was p...				US Patent US9597317 (2017) BindingDB Entry DOI: 10.7270/Q2N58PDX
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM239038 (US10028934, Compound 27 | US10478423, Cpd. 27 | US...) Show SMILES CN1CCC(CNc2ccc(cc2)C(=O)Nc2n[nH]c3cc(OCCOCc4ccccc4)ccc23)CC1 Show InChI InChI=1S/C30H35N5O3/c1-35-15-13-22(14-16-35)20-31-25-9-7-24(8-10-25)30(36)32-29-27-12-11-26(19-28(27)33-34-29)38-18-17-37-21-23-5-3-2-4-6-23/h2-12,19,22,31H,13-18,20-21H2,1H3,(H2,32,33,34,36)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
NERVIANO MEDICAL SCIENCES S.R.L. US Patent					Assay Description i. Enzyme The assay was performed using FLT3 cytoplasmic domain product and purified in house as GST fused protein. The FLT3 protein (1 microM) was p...				US Patent US9597317 (2017) BindingDB Entry DOI: 10.7270/Q2N58PDX
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM239023 (US10028934, Compound 32 | US10478423, Cpd. 32 | US...) Show SMILES CN1CCN(CC1)c1ccc(cc1)C(=O)Nc1n[nH]c2cc(OCCOCc3ccc(F)cc3)ccc12 Show InChI InChI=1S/C28H30FN5O3/c1-33-12-14-34(15-13-33)23-8-4-21(5-9-23)28(35)30-27-25-11-10-24(18-26(25)31-32-27)37-17-16-36-19-20-2-6-22(29)7-3-20/h2-11,18H,12-17,19H2,1H3,(H2,30,31,32,35)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
NERVIANO MEDICAL SCIENCES S.R.L. US Patent					Assay Description i. Enzyme The assay was performed using FLT3 cytoplasmic domain product and purified in house as GST fused protein. The FLT3 protein (1 microM) was p...				US Patent US9597317 (2017) BindingDB Entry DOI: 10.7270/Q2N58PDX
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM239023 (US10028934, Compound 32 | US10478423, Cpd. 32 | US...) Show SMILES CN1CCN(CC1)c1ccc(cc1)C(=O)Nc1n[nH]c2cc(OCCOCc3ccc(F)cc3)ccc12 Show InChI InChI=1S/C28H30FN5O3/c1-33-12-14-34(15-13-33)23-8-4-21(5-9-23)28(35)30-27-25-11-10-24(18-26(25)31-32-27)37-17-16-36-19-20-2-6-22(29)7-3-20/h2-11,18H,12-17,19H2,1H3,(H2,30,31,32,35)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
NERVIANO MEDICAL SCIENCES S.R.L. US Patent					Assay Description i. Enzyme The assay has been performed using KIT cytoplasmic domain product and purified in house as GST fused protein. The KIT protein (4.5 microM) ...				US Patent US9597317 (2017) BindingDB Entry DOI: 10.7270/Q2N58PDX
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM239022 (US10028934, Compound 33 | US10478423, Cpd. 33 | US...) Show SMILES CN1CCN(CC1)c1ccc(cc1)C(=O)Nc1n[nH]c2cc(OCCOCc3ccc(cc3)C(F)(F)F)ccc12 Show InChI InChI=1S/C29H30F3N5O3/c1-36-12-14-37(15-13-36)23-8-4-21(5-9-23)28(38)33-27-25-11-10-24(18-26(25)34-35-27)40-17-16-39-19-20-2-6-22(7-3-20)29(30,31)32/h2-11,18H,12-17,19H2,1H3,(H2,33,34,35,38)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
NERVIANO MEDICAL SCIENCES S.R.L. US Patent					Assay Description i. Enzyme The assay has been performed using KIT cytoplasmic domain product and purified in house as GST fused protein. The KIT protein (4.5 microM) ...				US Patent US9597317 (2017) BindingDB Entry DOI: 10.7270/Q2N58PDX
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM239026 (US10028934, Compound 40 | US10478423, Cpd. 40 | US...) Show SMILES COc1ccc(COCCOc2ccc3c(NC(=O)c4ccc(cc4)N4CCN(C)CC4)n[nH]c3c2)cc1 Show InChI InChI=1S/C29H33N5O4/c1-33-13-15-34(16-14-33)23-7-5-22(6-8-23)29(35)30-28-26-12-11-25(19-27(26)31-32-28)38-18-17-37-20-21-3-9-24(36-2)10-4-21/h3-12,19H,13-18,20H2,1-2H3,(H2,30,31,32,35)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
NERVIANO MEDICAL SCIENCES S.R.L. US Patent					Assay Description i. Enzyme The assay was performed using FLT3 cytoplasmic domain product and purified in house as GST fused protein. The FLT3 protein (1 microM) was p...				US Patent US9597317 (2017) BindingDB Entry DOI: 10.7270/Q2N58PDX
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM239042 (US10028934, Compound 42 | US10478423, Cpd. 42 | US...) Show SMILES C[N+]1([O-])CCN(CC1)c1ccc(cc1)C(=O)Nc1n[nH]c2cc(OCCOCc3ccc(cc3)C(F)(F)F)ccc12 Show InChI InChI=1S/C29H30F3N5O4/c1-37(39)14-12-36(13-15-37)23-8-4-21(5-9-23)28(38)33-27-25-11-10-24(18-26(25)34-35-27)41-17-16-40-19-20-2-6-22(7-3-20)29(30,31)32/h2-11,18H,12-17,19H2,1H3,(H2,33,34,35,38)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
NERVIANO MEDICAL SCIENCES S.R.L. US Patent					Assay Description i. Enzyme The assay was performed using FLT3 cytoplasmic domain product and purified in house as GST fused protein. The FLT3 protein (1 microM) was p...				US Patent US9597317 (2017) BindingDB Entry DOI: 10.7270/Q2N58PDX
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM239012 (US10028934, Compound 10 | US10478423, Cpd. 10 | US...) Show SMILES CN1CCN(CC1)c1ccc(cc1)C(=O)Nc1n[nH]c2cc(OCCOc3ccccc3)ccc12 Show InChI InChI=1S/C27H29N5O3/c1-31-13-15-32(16-14-31)21-9-7-20(8-10-21)27(33)28-26-24-12-11-23(19-25(24)29-30-26)35-18-17-34-22-5-3-2-4-6-22/h2-12,19H,13-18H2,1H3,(H2,28,29,30,33)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
NERVIANO MEDICAL SCIENCES S.R.L. US Patent					Assay Description i. Enzyme—The assay was performed using FLT3 cytoplasmic domain product and purified in house as GST fused protein. The FLT3 protein (1 microM) was p...				US Patent US10478423 (2019) BindingDB Entry DOI: 10.7270/Q2WQ065N
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM239017 (US10028934, Compound 11 | US10478423, Cpd. 11 | US...) Show SMILES CN1CCN(CC1)c1ccc(cc1)C(=O)Nc1n[nH]c2cc(OCCOCc3ccccc3)ccc12 Show InChI InChI=1S/C28H31N5O3/c1-32-13-15-33(16-14-32)23-9-7-22(8-10-23)28(34)29-27-25-12-11-24(19-26(25)30-31-27)36-18-17-35-20-21-5-3-2-4-6-21/h2-12,19H,13-18,20H2,1H3,(H2,29,30,31,34)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
NERVIANO MEDICAL SCIENCES S.R.L. US Patent					Assay Description i. Enzyme—The assay was performed using FLT3 cytoplasmic domain product and purified in house as GST fused protein. The FLT3 protein (1 microM) was p...				US Patent US10478423 (2019) BindingDB Entry DOI: 10.7270/Q2WQ065N
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM239040 (US10028934, Compound 14 | US10478423, Cpd. 14 | US...) Show SMILES C[N+]1([O-])CCN(CC1)c1ccc(cc1)C(=O)Nc1n[nH]c2cc(OCCOCc3ccccc3)ccc12 Show InChI InChI=1S/C28H31N5O4/c1-33(35)15-13-32(14-16-33)23-9-7-22(8-10-23)28(34)29-27-25-12-11-24(19-26(25)30-31-27)37-18-17-36-20-21-5-3-2-4-6-21/h2-12,19H,13-18,20H2,1H3,(H2,29,30,31,34)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
NERVIANO MEDICAL SCIENCES S.R.L. US Patent					Assay Description i. Enzyme—The assay was performed using FLT3 cytoplasmic domain product and purified in house as GST fused protein. The FLT3 protein (1 microM) was p...				US Patent US10478423 (2019) BindingDB Entry DOI: 10.7270/Q2WQ065N
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM239029 (US10028934, Compound 15 | US10478423, Cpd. 15 | US...) Show SMILES CN(C)C1CCN(CC1)c1ccc(cc1)C(=O)Nc1n[nH]c2cc(OCCOCc3ccccc3)ccc12 Show InChI InChI=1S/C30H35N5O3/c1-34(2)24-14-16-35(17-15-24)25-10-8-23(9-11-25)30(36)31-29-27-13-12-26(20-28(27)32-33-29)38-19-18-37-21-22-6-4-3-5-7-22/h3-13,20,24H,14-19,21H2,1-2H3,(H2,31,32,33,36)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
NERVIANO MEDICAL SCIENCES S.R.L. US Patent					Assay Description i. Enzyme—The assay was performed using FLT3 cytoplasmic domain product and purified in house as GST fused protein. The FLT3 protein (1 microM) was p...				US Patent US10478423 (2019) BindingDB Entry DOI: 10.7270/Q2WQ065N
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM239030 (US10028934, Compound 16 | US10478423, Cpd. 16 | US...) Show SMILES CN(C)CCN(C)c1ccc(cc1)C(=O)Nc1n[nH]c2cc(OCCOCc3ccccc3)ccc12 Show InChI InChI=1S/C28H33N5O3/c1-32(2)15-16-33(3)23-11-9-22(10-12-23)28(34)29-27-25-14-13-24(19-26(25)30-31-27)36-18-17-35-20-21-7-5-4-6-8-21/h4-14,19H,15-18,20H2,1-3H3,(H2,29,30,31,34)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
NERVIANO MEDICAL SCIENCES S.R.L. US Patent					Assay Description i. Enzyme—The assay was performed using FLT3 cytoplasmic domain product and purified in house as GST fused protein. The FLT3 protein (1 microM) was p...				US Patent US10478423 (2019) BindingDB Entry DOI: 10.7270/Q2WQ065N
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM239033 (US10028934, Compound 19 | US10478423, Cpd. 19 | US...) Show SMILES CN1CCC(CC1)Nc1ccc(cc1)C(=O)Nc1n[nH]c2cc(OCCOCc3ccccc3)ccc12 Show InChI InChI=1S/C29H33N5O3/c1-34-15-13-24(14-16-34)30-23-9-7-22(8-10-23)29(35)31-28-26-12-11-25(19-27(26)32-33-28)37-18-17-36-20-21-5-3-2-4-6-21/h2-12,19,24,30H,13-18,20H2,1H3,(H2,31,32,33,35)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
NERVIANO MEDICAL SCIENCES S.R.L. US Patent					Assay Description i. Enzyme—The assay was performed using FLT3 cytoplasmic domain product and purified in house as GST fused protein. The FLT3 protein (1 microM) was p...				US Patent US10478423 (2019) BindingDB Entry DOI: 10.7270/Q2WQ065N
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM239043 (US10028934, Compound 20 | US10478423, Cpd. 20 | US...) Show SMILES O=C(Nc1n[nH]c2cc(OCCOCc3ccccc3)ccc12)c1ccc(cc1)N1CCNCC1 Show InChI InChI=1S/C27H29N5O3/c33-27(21-6-8-22(9-7-21)32-14-12-28-13-15-32)29-26-24-11-10-23(18-25(24)30-31-26)35-17-16-34-19-20-4-2-1-3-5-20/h1-11,18,28H,12-17,19H2,(H2,29,30,31,33)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
NERVIANO MEDICAL SCIENCES S.R.L. US Patent					Assay Description i. Enzyme—The assay was performed using FLT3 cytoplasmic domain product and purified in house as GST fused protein. The FLT3 protein (1 microM) was p...				US Patent US10478423 (2019) BindingDB Entry DOI: 10.7270/Q2WQ065N
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM239034 (US10028934, Compound 23 | US10478423, Cpd. 23 | US...) Show SMILES CN(C1CCN(C)CC1)c1ccc(cc1)C(=O)Nc1n[nH]c2cc(OCCOCc3ccccc3)ccc12 Show InChI InChI=1S/C30H35N5O3/c1-34-16-14-25(15-17-34)35(2)24-10-8-23(9-11-24)30(36)31-29-27-13-12-26(20-28(27)32-33-29)38-19-18-37-21-22-6-4-3-5-7-22/h3-13,20,25H,14-19,21H2,1-2H3,(H2,31,32,33,36)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
NERVIANO MEDICAL SCIENCES S.R.L. US Patent					Assay Description i. Enzyme—The assay was performed using FLT3 cytoplasmic domain product and purified in house as GST fused protein. The FLT3 protein (1 microM) was p...				US Patent US10478423 (2019) BindingDB Entry DOI: 10.7270/Q2WQ065N
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM239038 (US10028934, Compound 27 | US10478423, Cpd. 27 | US...) Show SMILES CN1CCC(CNc2ccc(cc2)C(=O)Nc2n[nH]c3cc(OCCOCc4ccccc4)ccc23)CC1 Show InChI InChI=1S/C30H35N5O3/c1-35-15-13-22(14-16-35)20-31-25-9-7-24(8-10-25)30(36)32-29-27-12-11-26(19-28(27)33-34-29)38-18-17-37-21-23-5-3-2-4-6-23/h2-12,19,22,31H,13-18,20-21H2,1H3,(H2,32,33,34,36)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
NERVIANO MEDICAL SCIENCES S.R.L. US Patent					Assay Description i. Enzyme—The assay was performed using FLT3 cytoplasmic domain product and purified in house as GST fused protein. The FLT3 protein (1 microM) was p...				US Patent US10478423 (2019) BindingDB Entry DOI: 10.7270/Q2WQ065N
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM239023 (US10028934, Compound 32 | US10478423, Cpd. 32 | US...) Show SMILES CN1CCN(CC1)c1ccc(cc1)C(=O)Nc1n[nH]c2cc(OCCOCc3ccc(F)cc3)ccc12 Show InChI InChI=1S/C28H30FN5O3/c1-33-12-14-34(15-13-33)23-8-4-21(5-9-23)28(35)30-27-25-11-10-24(18-26(25)31-32-27)37-17-16-36-19-20-2-6-22(29)7-3-20/h2-11,18H,12-17,19H2,1H3,(H2,30,31,32,35)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
NERVIANO MEDICAL SCIENCES S.R.L. US Patent					Assay Description i. Enzyme—The assay was performed using FLT3 cytoplasmic domain product and purified in house as GST fused protein. The FLT3 protein (1 microM) was p...				US Patent US10478423 (2019) BindingDB Entry DOI: 10.7270/Q2WQ065N
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM239023 (US10028934, Compound 32 | US10478423, Cpd. 32 | US...) Show SMILES CN1CCN(CC1)c1ccc(cc1)C(=O)Nc1n[nH]c2cc(OCCOCc3ccc(F)cc3)ccc12 Show InChI InChI=1S/C28H30FN5O3/c1-33-12-14-34(15-13-33)23-8-4-21(5-9-23)28(35)30-27-25-11-10-24(18-26(25)31-32-27)37-17-16-36-19-20-2-6-22(29)7-3-20/h2-11,18H,12-17,19H2,1H3,(H2,30,31,32,35)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
NERVIANO MEDICAL SCIENCES S.R.L. US Patent					Assay Description i. Enzyme—The assay has been performed using KIT cytoplasmic domain product and purified in house as GST fused protein. The KIT protein (4.5 microM) ...				US Patent US10478423 (2019) BindingDB Entry DOI: 10.7270/Q2WQ065N
					More data for this Ligand-Target Pair

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