Compile Data Set for Download or QSAR

Found 101 hits with Last Name = 'miknyoczki' and Initial = 'sj'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Adenosine receptor A2a (Homo sapiens (Human))	BDBM50379186 (CEP-11981 | CHEMBL2010872) Show SMILES CC(C)Cn1c2ccc(Nc3ncccn3)cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12 Show InChI InChI=1S/C28H27N7O/c1-15(2)13-35-22-8-5-16(32-28-29-9-4-10-30-28)11-18(22)24-19-12-31-27(36)25(19)23-17(26(24)35)6-7-21-20(23)14-34(3)33-21/h4-5,8-11,14-15H,6-7,12-13H2,1-3H3,(H,31,36)(H,29,30,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc. Curated by ChEMBL					Assay Description Inhibition of adenosine A2A receptor				J Med Chem 55: 903-13 (2012) Article DOI: 10.1021/jm201449n BindingDB Entry DOI: 10.7270/Q2ZS2XHW
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M4 (Homo sapiens (Human))	BDBM50379186 (CEP-11981 | CHEMBL2010872) Show SMILES CC(C)Cn1c2ccc(Nc3ncccn3)cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12 Show InChI InChI=1S/C28H27N7O/c1-15(2)13-35-22-8-5-16(32-28-29-9-4-10-30-28)11-18(22)24-19-12-31-27(36)25(19)23-17(26(24)35)6-7-21-20(23)14-34(3)33-21/h4-5,8-11,14-15H,6-7,12-13H2,1-3H3,(H,31,36)(H,29,30,32)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	2.90E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc. Curated by ChEMBL					Assay Description Inhibition of muscarinic M4 receptor				J Med Chem 55: 903-13 (2012) Article DOI: 10.1021/jm201449n BindingDB Entry DOI: 10.7270/Q2ZS2XHW
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM50379186 (CEP-11981 | CHEMBL2010872) Show SMILES CC(C)Cn1c2ccc(Nc3ncccn3)cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12 Show InChI InChI=1S/C28H27N7O/c1-15(2)13-35-22-8-5-16(32-28-29-9-4-10-30-28)11-18(22)24-19-12-31-27(36)25(19)23-17(26(24)35)6-7-21-20(23)14-34(3)33-21/h4-5,8-11,14-15H,6-7,12-13H2,1-3H3,(H,31,36)(H,29,30,32)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc. Curated by ChEMBL					Assay Description Inhibition of human TRK-A using ATP as substrate				J Med Chem 55: 903-13 (2012) Article DOI: 10.1021/jm201449n BindingDB Entry DOI: 10.7270/Q2ZS2XHW
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50379196 (CHEMBL2010870) Show SMILES CC(C)n1c2ccc(Nc3ncccn3)cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12 Show InChI InChI=1S/C27H25N7O/c1-14(2)34-21-8-5-15(31-27-28-9-4-10-29-27)11-17(21)23-18-12-30-26(35)24(18)22-16(25(23)34)6-7-20-19(22)13-33(3)32-20/h4-5,8-11,13-14H,6-7,12H2,1-3H3,(H,30,35)(H,28,29,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc. Curated by ChEMBL					Assay Description Inhibition of human recombinant VEGF-R2 expressed in baculovirus expression system using GST-PLCgamma as substrate after 1 hr by time-resolved fluore...				J Med Chem 55: 903-13 (2012) Article DOI: 10.1021/jm201449n BindingDB Entry DOI: 10.7270/Q2ZS2XHW
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 1 (Homo sapiens (Human))	BDBM50379186 (CEP-11981 | CHEMBL2010872) Show SMILES CC(C)Cn1c2ccc(Nc3ncccn3)cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12 Show InChI InChI=1S/C28H27N7O/c1-15(2)13-35-22-8-5-16(32-28-29-9-4-10-30-28)11-18(22)24-19-12-31-27(36)25(19)23-17(26(24)35)6-7-21-20(23)14-34(3)33-21/h4-5,8-11,14-15H,6-7,12-13H2,1-3H3,(H,31,36)(H,29,30,32)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc. Curated by ChEMBL					Assay Description Inhibition of human VEGFR1 using ATP as substrate				J Med Chem 55: 903-13 (2012) Article DOI: 10.1021/jm201449n BindingDB Entry DOI: 10.7270/Q2ZS2XHW
					More data for this Ligand-Target Pair
Angiopoietin-1 receptor (Homo sapiens (Human))	BDBM50379195 (CHEMBL2010869) Show SMILES CCCn1c2ccc(Nc3ncc(CC)cn3)cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12 Show InChI InChI=1S/C29H29N7O/c1-4-10-36-23-9-6-17(33-29-31-12-16(5-2)13-32-29)11-19(23)25-20-14-30-28(37)26(20)24-18(27(25)36)7-8-22-21(24)15-35(3)34-22/h6,9,11-13,15H,4-5,7-8,10,14H2,1-3H3,(H,30,37)(H,31,32,33)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc. Curated by ChEMBL					Assay Description Inhibition of human recombinant Tie2 expressed in baculovirus expression system using GST-PLCgamma as substrate after 1 hr by time-resolved fluoresce...				J Med Chem 55: 903-13 (2012) Article DOI: 10.1021/jm201449n BindingDB Entry DOI: 10.7270/Q2ZS2XHW
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50379186 (CEP-11981 | CHEMBL2010872) Show SMILES CC(C)Cn1c2ccc(Nc3ncccn3)cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12 Show InChI InChI=1S/C28H27N7O/c1-15(2)13-35-22-8-5-16(32-28-29-9-4-10-30-28)11-18(22)24-19-12-31-27(36)25(19)23-17(26(24)35)6-7-21-20(23)14-34(3)33-21/h4-5,8-11,14-15H,6-7,12-13H2,1-3H3,(H,31,36)(H,29,30,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc. Curated by ChEMBL					Assay Description Inhibition of human recombinant VEGF-R2 expressed in baculovirus expression system using GST-PLCgamma as substrate after 1 hr by time-resolved fluore...				J Med Chem 55: 903-13 (2012) Article DOI: 10.1021/jm201449n BindingDB Entry DOI: 10.7270/Q2ZS2XHW
					More data for this Ligand-Target Pair
BDNF/NT-3 growth factors receptor (Homo sapiens (Human))	BDBM50379186 (CEP-11981 | CHEMBL2010872) Show SMILES CC(C)Cn1c2ccc(Nc3ncccn3)cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12 Show InChI InChI=1S/C28H27N7O/c1-15(2)13-35-22-8-5-16(32-28-29-9-4-10-30-28)11-18(22)24-19-12-31-27(36)25(19)23-17(26(24)35)6-7-21-20(23)14-34(3)33-21/h4-5,8-11,14-15H,6-7,12-13H2,1-3H3,(H,31,36)(H,29,30,32)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc. Curated by ChEMBL					Assay Description Inhibition of human TRK-B using ATP as substrate				J Med Chem 55: 903-13 (2012) Article DOI: 10.1021/jm201449n BindingDB Entry DOI: 10.7270/Q2ZS2XHW
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM50379186 (CEP-11981 | CHEMBL2010872) Show SMILES CC(C)Cn1c2ccc(Nc3ncccn3)cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12 Show InChI InChI=1S/C28H27N7O/c1-15(2)13-35-22-8-5-16(32-28-29-9-4-10-30-28)11-18(22)24-19-12-31-27(36)25(19)23-17(26(24)35)6-7-21-20(23)14-34(3)33-21/h4-5,8-11,14-15H,6-7,12-13H2,1-3H3,(H,31,36)(H,29,30,32)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc. Curated by ChEMBL					Assay Description Inhibition of human RET using ATP as substrate				J Med Chem 55: 903-13 (2012) Article DOI: 10.1021/jm201449n BindingDB Entry DOI: 10.7270/Q2ZS2XHW
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50379193 (CHEMBL2010871) Show SMILES CCCn1c2ccc(Nc3ncccn3)cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12 Show InChI InChI=1S/C27H25N7O/c1-3-11-34-21-8-5-15(31-27-28-9-4-10-29-27)12-17(21)23-18-13-30-26(35)24(18)22-16(25(23)34)6-7-20-19(22)14-33(2)32-20/h4-5,8-10,12,14H,3,6-7,11,13H2,1-2H3,(H,30,35)(H,28,29,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc. Curated by ChEMBL					Assay Description Inhibition of human recombinant VEGF-R2 expressed in baculovirus expression system using GST-PLCgamma as substrate after 1 hr by time-resolved fluore...				J Med Chem 55: 903-13 (2012) Article DOI: 10.1021/jm201449n BindingDB Entry DOI: 10.7270/Q2ZS2XHW
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Blk (Mus musculus)	BDBM50379186 (CEP-11981 | CHEMBL2010872) Show SMILES CC(C)Cn1c2ccc(Nc3ncccn3)cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12 Show InChI InChI=1S/C28H27N7O/c1-15(2)13-35-22-8-5-16(32-28-29-9-4-10-30-28)11-18(22)24-19-12-31-27(36)25(19)23-17(26(24)35)6-7-21-20(23)14-34(3)33-21/h4-5,8-11,14-15H,6-7,12-13H2,1-3H3,(H,31,36)(H,29,30,32)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc. Curated by ChEMBL					Assay Description Inhibition of mouse BLK using ATP as substrate				J Med Chem 55: 903-13 (2012) Article DOI: 10.1021/jm201449n BindingDB Entry DOI: 10.7270/Q2ZS2XHW
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50333561 (2-{5-Chloro-2-[3-(2-methoxy-ethyl)-2,3,4,5-tetrahy...) Show SMILES CNC(=O)c1cccc(F)c1Nc1nc(Nc2ccc3CCN(CCOC)CCc3c2)ncc1Cl Show InChI InChI=1S/C25H28ClFN6O2/c1-28-24(34)19-4-3-5-21(27)22(19)31-23-20(26)15-29-25(32-23)30-18-7-6-16-8-10-33(12-13-35-2)11-9-17(16)14-18/h3-7,14-15H,8-13H2,1-2H3,(H,28,34)(H2,29,30,31,32)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc. Curated by ChEMBL					Assay Description Inhibition of c-Met cytoplasmic domain expressed in baculovirus after 30 mins by time-resolved fluorescence assay				Bioorg Med Chem Lett 21: 660-3 (2011) Article DOI: 10.1016/j.bmcl.2010.12.013 BindingDB Entry DOI: 10.7270/Q2RB74WV
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50379195 (CHEMBL2010869) Show SMILES CCCn1c2ccc(Nc3ncc(CC)cn3)cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12 Show InChI InChI=1S/C29H29N7O/c1-4-10-36-23-9-6-17(33-29-31-12-16(5-2)13-32-29)11-19(23)25-20-14-30-28(37)26(20)24-18(27(25)36)7-8-22-21(24)15-35(3)34-22/h6,9,11-13,15H,4-5,7-8,10,14H2,1-3H3,(H,30,37)(H,31,32,33)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc. Curated by ChEMBL					Assay Description Inhibition of human recombinant VEGF-R2 expressed in baculovirus expression system using GST-PLCgamma as substrate after 1 hr by time-resolved fluore...				J Med Chem 55: 903-13 (2012) Article DOI: 10.1021/jm201449n BindingDB Entry DOI: 10.7270/Q2ZS2XHW
					More data for this Ligand-Target Pair
Angiopoietin-1 receptor (Homo sapiens (Human))	BDBM50379194 (CHEMBL2010873) Show SMILES CCc1cnc(Nc2ccc3n(CC(C)C)c4c5CCc6nn(C)cc6-c5c5C(=O)NCc5c4c3c2)nc1 Show InChI InChI=1S/C30H31N7O/c1-5-17-11-32-30(33-12-17)34-18-6-9-24-20(10-18)26-21-13-31-29(38)27(21)25-19(28(26)37(24)14-16(2)3)7-8-23-22(25)15-36(4)35-23/h6,9-12,15-16H,5,7-8,13-14H2,1-4H3,(H,31,38)(H,32,33,34)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc. Curated by ChEMBL					Assay Description Inhibition of human recombinant Tie2 expressed in baculovirus expression system using GST-PLCgamma as substrate after 1 hr by time-resolved fluoresce...				J Med Chem 55: 903-13 (2012) Article DOI: 10.1021/jm201449n BindingDB Entry DOI: 10.7270/Q2ZS2XHW
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50379192 (CHEMBL2010877) Show SMILES CC(C)n1c2ccc(Nc3cccnn3)cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12 Show InChI InChI=1S/C27H25N7O/c1-14(2)34-21-9-6-15(30-22-5-4-10-29-31-22)11-17(21)24-18-12-28-27(35)25(18)23-16(26(24)34)7-8-20-19(23)13-33(3)32-20/h4-6,9-11,13-14H,7-8,12H2,1-3H3,(H,28,35)(H,30,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc. Curated by ChEMBL					Assay Description Inhibition of human recombinant VEGF-R2 expressed in baculovirus expression system using GST-PLCgamma as substrate after 1 hr by time-resolved fluore...				J Med Chem 55: 903-13 (2012) Article DOI: 10.1021/jm201449n BindingDB Entry DOI: 10.7270/Q2ZS2XHW
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50333572 (2-{5-Chloro-2-[9-(2-methoxy-acetyl)-6,7,8,9-tetrah...) Show SMILES CNC(=O)c1cccc(F)c1Nc1nc(Nc2ccc3N(CCCOc3c2)C(=O)COC)ncc1Cl Show InChI InChI=1S/C24H24ClFN6O4/c1-27-23(34)15-5-3-6-17(26)21(15)30-22-16(25)12-28-24(31-22)29-14-7-8-18-19(11-14)36-10-4-9-32(18)20(33)13-35-2/h3,5-8,11-12H,4,9-10,13H2,1-2H3,(H,27,34)(H2,28,29,30,31)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc. Curated by ChEMBL					Assay Description Inhibition of c-Met cytoplasmic domain expressed in baculovirus after 30 mins by time-resolved fluorescence assay				Bioorg Med Chem Lett 21: 660-3 (2011) Article DOI: 10.1016/j.bmcl.2010.12.013 BindingDB Entry DOI: 10.7270/Q2RB74WV
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM50379186 (CEP-11981 | CHEMBL2010872) Show SMILES CC(C)Cn1c2ccc(Nc3ncccn3)cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12 Show InChI InChI=1S/C28H27N7O/c1-15(2)13-35-22-8-5-16(32-28-29-9-4-10-30-28)11-18(22)24-19-12-31-27(36)25(19)23-17(26(24)35)6-7-21-20(23)14-34(3)33-21/h4-5,8-11,14-15H,6-7,12-13H2,1-3H3,(H,31,36)(H,29,30,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc. Curated by ChEMBL					Assay Description Inhibition of human FGFR1 using ATP as substrate				J Med Chem 55: 903-13 (2012) Article DOI: 10.1021/jm201449n BindingDB Entry DOI: 10.7270/Q2ZS2XHW
					More data for this Ligand-Target Pair
Nuclear receptor subfamily 2 group C member 2 (Homo sapiens (Human))	BDBM50379186 (CEP-11981 | CHEMBL2010872) Show SMILES CC(C)Cn1c2ccc(Nc3ncccn3)cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12 Show InChI InChI=1S/C28H27N7O/c1-15(2)13-35-22-8-5-16(32-28-29-9-4-10-30-28)11-18(22)24-19-12-31-27(36)25(19)23-17(26(24)35)6-7-21-20(23)14-34(3)33-21/h4-5,8-11,14-15H,6-7,12-13H2,1-3H3,(H,31,36)(H,29,30,32)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc. Curated by ChEMBL					Assay Description Inhibition of human TAK1 using ATP as substrate				J Med Chem 55: 903-13 (2012) Article DOI: 10.1021/jm201449n BindingDB Entry DOI: 10.7270/Q2ZS2XHW
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50379194 (CHEMBL2010873) Show SMILES CCc1cnc(Nc2ccc3n(CC(C)C)c4c5CCc6nn(C)cc6-c5c5C(=O)NCc5c4c3c2)nc1 Show InChI InChI=1S/C30H31N7O/c1-5-17-11-32-30(33-12-17)34-18-6-9-24-20(10-18)26-21-13-31-29(38)27(21)25-19(28(26)37(24)14-16(2)3)7-8-23-22(25)15-36(4)35-23/h6,9-12,15-16H,5,7-8,13-14H2,1-4H3,(H,31,38)(H,32,33,34)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc. Curated by ChEMBL					Assay Description Inhibition of human recombinant VEGF-R2 expressed in baculovirus expression system using GST-PLCgamma as substrate after 1 hr by time-resolved fluore...				J Med Chem 55: 903-13 (2012) Article DOI: 10.1021/jm201449n BindingDB Entry DOI: 10.7270/Q2ZS2XHW
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50333567 (2-[5-Chloro-2-(9-ethyl-6,7,8,9-tetrahydro-5-oxa-9-...) Show SMILES CCN1CCCOc2cc(Nc3ncc(Cl)c(Nc4c(F)cccc4C(=O)NC)n3)ccc12 Show InChI InChI=1S/C23H24ClFN6O2/c1-3-31-10-5-11-33-19-12-14(8-9-18(19)31)28-23-27-13-16(24)21(30-23)29-20-15(22(32)26-2)6-4-7-17(20)25/h4,6-9,12-13H,3,5,10-11H2,1-2H3,(H,26,32)(H2,27,28,29,30)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc. Curated by ChEMBL					Assay Description Inhibition of c-Met cytoplasmic domain expressed in baculovirus after 30 mins by time-resolved fluorescence assay				Bioorg Med Chem Lett 21: 660-3 (2011) Article DOI: 10.1016/j.bmcl.2010.12.013 BindingDB Entry DOI: 10.7270/Q2RB74WV
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50333575 (2-[2-(9-Acetyl-6,7,8,9-tetrahydro-5-oxa-9-aza-benz...) Show SMILES CNC(=O)c1cccc(F)c1Nc1nc(Nc2ccc3OCCCN(C(C)=O)c3c2)ncc1Cl Show InChI InChI=1S/C23H22ClFN6O3/c1-13(32)31-9-4-10-34-19-8-7-14(11-18(19)31)28-23-27-12-16(24)21(30-23)29-20-15(22(33)26-2)5-3-6-17(20)25/h3,5-8,11-12H,4,9-10H2,1-2H3,(H,26,33)(H2,27,28,29,30)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	17	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc. Curated by ChEMBL					Assay Description Inhibition of c-Met cytoplasmic domain expressed in baculovirus after 30 mins by time-resolved fluorescence assay				Bioorg Med Chem Lett 21: 660-3 (2011) Article DOI: 10.1016/j.bmcl.2010.12.013 BindingDB Entry DOI: 10.7270/Q2RB74WV
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50333567 (2-[5-Chloro-2-(9-ethyl-6,7,8,9-tetrahydro-5-oxa-9-...) Show SMILES CCN1CCCOc2cc(Nc3ncc(Cl)c(Nc4c(F)cccc4C(=O)NC)n3)ccc12 Show InChI InChI=1S/C23H24ClFN6O2/c1-3-31-10-5-11-33-19-12-14(8-9-18(19)31)28-23-27-13-16(24)21(30-23)29-20-15(22(32)26-2)6-4-7-17(20)25/h4,6-9,12-13H,3,5,10-11H2,1-2H3,(H,26,32)(H2,27,28,29,30)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	18	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc. Curated by ChEMBL					Assay Description Inhibition of c-Met expressed in human GTL-16 cells after 2 hrs				Bioorg Med Chem Lett 21: 660-3 (2011) Article DOI: 10.1016/j.bmcl.2010.12.013 BindingDB Entry DOI: 10.7270/Q2RB74WV
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50333561 (2-{5-Chloro-2-[3-(2-methoxy-ethyl)-2,3,4,5-tetrahy...) Show SMILES CNC(=O)c1cccc(F)c1Nc1nc(Nc2ccc3CCN(CCOC)CCc3c2)ncc1Cl Show InChI InChI=1S/C25H28ClFN6O2/c1-28-24(34)19-4-3-5-21(27)22(19)31-23-20(26)15-29-25(32-23)30-18-7-6-16-8-10-33(12-13-35-2)11-9-17(16)14-18/h3-7,14-15H,8-13H2,1-2H3,(H,28,34)(H2,29,30,31,32)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	19	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc. Curated by ChEMBL					Assay Description Inhibition of c-Met expressed in human GTL-16 cells after 2 hrs				Bioorg Med Chem Lett 21: 660-3 (2011) Article DOI: 10.1016/j.bmcl.2010.12.013 BindingDB Entry DOI: 10.7270/Q2RB74WV
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50333571 (2-{5-Chloro-2-[9-(2-pyrrolidin-1-yl-acetyl)-6,7,8,...) Show SMILES CNC(=O)c1cccc(F)c1Nc1nc(Nc2ccc3N(CCCOc3c2)C(=O)CN2CCCC2)ncc1Cl Show InChI InChI=1S/C27H29ClFN7O3/c1-30-26(38)18-6-4-7-20(29)24(18)33-25-19(28)15-31-27(34-25)32-17-8-9-21-22(14-17)39-13-5-12-36(21)23(37)16-35-10-2-3-11-35/h4,6-9,14-15H,2-3,5,10-13,16H2,1H3,(H,30,38)(H2,31,32,33,34)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	19	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc. Curated by ChEMBL					Assay Description Inhibition of c-Met expressed in human GTL-16 cells after 2 hrs				Bioorg Med Chem Lett 21: 660-3 (2011) Article DOI: 10.1016/j.bmcl.2010.12.013 BindingDB Entry DOI: 10.7270/Q2RB74WV
					More data for this Ligand-Target Pair
Insulin receptor (Homo sapiens (Human))	BDBM50333558 (2-{5-Chloro-2-[3-(2-methoxy-ethyl)-2,3,4,5-tetrahy...) Show SMILES CNC(=O)c1ccccc1Nc1nc(Nc2ccc3CCN(CCOC)CCc3c2)ncc1Cl Show InChI InChI=1S/C25H29ClN6O2/c1-27-24(33)20-5-3-4-6-22(20)30-23-21(26)16-28-25(31-23)29-19-8-7-17-9-11-32(13-14-34-2)12-10-18(17)15-19/h3-8,15-16H,9-14H2,1-2H3,(H,27,33)(H2,28,29,30,31)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc. Curated by ChEMBL					Assay Description Inhibition of insulin receptor after 1 hr				Bioorg Med Chem Lett 21: 660-3 (2011) Article DOI: 10.1016/j.bmcl.2010.12.013 BindingDB Entry DOI: 10.7270/Q2RB74WV
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50333568 (2-{5-Chloro-2-[9-(2-pyrrolidin-1-yl-ethyl)-6,7,8,9...) Show SMILES CNC(=O)c1cccc(F)c1Nc1nc(Nc2ccc3N(CCN4CCCC4)CCCOc3c2)ncc1Cl Show InChI InChI=1S/C27H31ClFN7O2/c1-30-26(37)19-6-4-7-21(29)24(19)33-25-20(28)17-31-27(34-25)32-18-8-9-22-23(16-18)38-15-5-12-36(22)14-13-35-10-2-3-11-35/h4,6-9,16-17H,2-3,5,10-15H2,1H3,(H,30,37)(H2,31,32,33,34)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	21	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc. Curated by ChEMBL					Assay Description Inhibition of c-Met cytoplasmic domain expressed in baculovirus after 30 mins by time-resolved fluorescence assay				Bioorg Med Chem Lett 21: 660-3 (2011) Article DOI: 10.1016/j.bmcl.2010.12.013 BindingDB Entry DOI: 10.7270/Q2RB74WV
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase 3 (Homo sapiens (Human))	BDBM50379186 (CEP-11981 | CHEMBL2010872) Show SMILES CC(C)Cn1c2ccc(Nc3ncccn3)cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12 Show InChI InChI=1S/C28H27N7O/c1-15(2)13-35-22-8-5-16(32-28-29-9-4-10-30-28)11-18(22)24-19-12-31-27(36)25(19)23-17(26(24)35)6-7-21-20(23)14-34(3)33-21/h4-5,8-11,14-15H,6-7,12-13H2,1-3H3,(H,31,36)(H,29,30,32)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	21	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc. Curated by ChEMBL					Assay Description Inhibition of human MST2 using ATP as substrate				J Med Chem 55: 903-13 (2012) Article DOI: 10.1021/jm201449n BindingDB Entry DOI: 10.7270/Q2ZS2XHW
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50333568 (2-{5-Chloro-2-[9-(2-pyrrolidin-1-yl-ethyl)-6,7,8,9...) Show SMILES CNC(=O)c1cccc(F)c1Nc1nc(Nc2ccc3N(CCN4CCCC4)CCCOc3c2)ncc1Cl Show InChI InChI=1S/C27H31ClFN7O2/c1-30-26(37)19-6-4-7-21(29)24(19)33-25-20(28)17-31-27(34-25)32-18-8-9-22-23(16-18)38-15-5-12-36(22)14-13-35-10-2-3-11-35/h4,6-9,16-17H,2-3,5,10-15H2,1H3,(H,30,37)(H2,31,32,33,34)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	22	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc. Curated by ChEMBL					Assay Description Inhibition of c-Met expressed in human GTL-16 cells after 2 hrs				Bioorg Med Chem Lett 21: 660-3 (2011) Article DOI: 10.1016/j.bmcl.2010.12.013 BindingDB Entry DOI: 10.7270/Q2RB74WV
					More data for this Ligand-Target Pair
Angiopoietin-1 receptor (Homo sapiens (Human))	BDBM50379186 (CEP-11981 | CHEMBL2010872) Show SMILES CC(C)Cn1c2ccc(Nc3ncccn3)cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12 Show InChI InChI=1S/C28H27N7O/c1-15(2)13-35-22-8-5-16(32-28-29-9-4-10-30-28)11-18(22)24-19-12-31-27(36)25(19)23-17(26(24)35)6-7-21-20(23)14-34(3)33-21/h4-5,8-11,14-15H,6-7,12-13H2,1-3H3,(H,31,36)(H,29,30,32)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	22	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc. Curated by ChEMBL					Assay Description Inhibition of human recombinant Tie2 expressed in baculovirus expression system using GST-PLCgamma as substrate after 1 hr by time-resolved fluoresce...				J Med Chem 55: 903-13 (2012) Article DOI: 10.1021/jm201449n BindingDB Entry DOI: 10.7270/Q2ZS2XHW
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50333559 (3-Chloro-2-{5-chloro-2-[3-(2-methoxy-ethyl)-2,3,4,...) Show SMILES CNC(=O)c1cccc(Cl)c1Nc1nc(Nc2ccc3CCN(CCOC)CCc3c2)ncc1Cl Show InChI InChI=1S/C25H28Cl2N6O2/c1-28-24(34)19-4-3-5-20(26)22(19)31-23-21(27)15-29-25(32-23)30-18-7-6-16-8-10-33(12-13-35-2)11-9-17(16)14-18/h3-7,14-15H,8-13H2,1-2H3,(H,28,34)(H2,29,30,31,32)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	24	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc. Curated by ChEMBL					Assay Description Inhibition of c-Met cytoplasmic domain expressed in baculovirus after 30 mins by time-resolved fluorescence assay				Bioorg Med Chem Lett 21: 660-3 (2011) Article DOI: 10.1016/j.bmcl.2010.12.013 BindingDB Entry DOI: 10.7270/Q2RB74WV
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50333563 (3-[5-Chloro-4-(2-fluoro-6-methylcarbamoyl-phenylam...) Show SMILES CCOC(=O)N1CCCOc2cc(Nc3ncc(Cl)c(Nc4c(F)cccc4C(=O)NC)n3)ccc12 Show InChI InChI=1S/C24H24ClFN6O4/c1-3-35-24(34)32-10-5-11-36-19-12-14(8-9-18(19)32)29-23-28-13-16(25)21(31-23)30-20-15(22(33)27-2)6-4-7-17(20)26/h4,6-9,12-13H,3,5,10-11H2,1-2H3,(H,27,33)(H2,28,29,30,31)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	25	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc. Curated by ChEMBL					Assay Description Inhibition of c-Met cytoplasmic domain expressed in baculovirus after 30 mins by time-resolved fluorescence assay				Bioorg Med Chem Lett 21: 660-3 (2011) Article DOI: 10.1016/j.bmcl.2010.12.013 BindingDB Entry DOI: 10.7270/Q2RB74WV
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50333560 (2-{5-Chloro-2-[3-(2-methoxy-ethyl)-2,3,4,5-tetrahy...) Show SMILES CNC(=O)c1cccc(C)c1Nc1nc(Nc2ccc3CCN(CCOC)CCc3c2)ncc1Cl Show InChI InChI=1S/C26H31ClN6O2/c1-17-5-4-6-21(25(34)28-2)23(17)31-24-22(27)16-29-26(32-24)30-20-8-7-18-9-11-33(13-14-35-3)12-10-19(18)15-20/h4-8,15-16H,9-14H2,1-3H3,(H,28,34)(H2,29,30,31,32)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	26	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc. Curated by ChEMBL					Assay Description Inhibition of c-Met cytoplasmic domain expressed in baculovirus after 30 mins by time-resolved fluorescence assay				Bioorg Med Chem Lett 21: 660-3 (2011) Article DOI: 10.1016/j.bmcl.2010.12.013 BindingDB Entry DOI: 10.7270/Q2RB74WV
					More data for this Ligand-Target Pair
Angiopoietin-1 receptor (Homo sapiens (Human))	BDBM50379193 (CHEMBL2010871) Show SMILES CCCn1c2ccc(Nc3ncccn3)cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12 Show InChI InChI=1S/C27H25N7O/c1-3-11-34-21-8-5-15(31-27-28-9-4-10-29-27)12-17(21)23-18-13-30-26(35)24(18)22-16(25(23)34)6-7-20-19(22)14-33(2)32-20/h4-5,8-10,12,14H,3,6-7,11,13H2,1-2H3,(H,30,35)(H,28,29,31)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	27	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc. Curated by ChEMBL					Assay Description Inhibition of human recombinant Tie2 expressed in baculovirus expression system using GST-PLCgamma as substrate after 1 hr by time-resolved fluoresce...				J Med Chem 55: 903-13 (2012) Article DOI: 10.1021/jm201449n BindingDB Entry DOI: 10.7270/Q2ZS2XHW
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50333566 (3-[5-Chloro-4-(2-fluoro-6-methylcarbamoyl-phenylam...) Show SMILES CNC(=O)c1cccc(F)c1Nc1nc(Nc2ccc3N(CCCOc3c2)C(=O)OCCCN(C)C)ncc1Cl Show InChI InChI=1S/C27H31ClFN7O4/c1-30-25(37)18-7-4-8-20(29)23(18)33-24-19(28)16-31-26(34-24)32-17-9-10-21-22(15-17)39-13-6-12-36(21)27(38)40-14-5-11-35(2)3/h4,7-10,15-16H,5-6,11-14H2,1-3H3,(H,30,37)(H2,31,32,33,34)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	28	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc. Curated by ChEMBL					Assay Description Inhibition of c-Met expressed in human GTL-16 cells after 2 hrs				Bioorg Med Chem Lett 21: 660-3 (2011) Article DOI: 10.1016/j.bmcl.2010.12.013 BindingDB Entry DOI: 10.7270/Q2RB74WV
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50333570 (2-[2-(9-Acetyl-6,7,8,9-tetrahydro-5-oxa-9-aza-benz...) Show SMILES CNC(=O)c1cccc(F)c1Nc1nc(Nc2ccc3N(CCCOc3c2)C(C)=O)ncc1Cl Show InChI InChI=1S/C23H22ClFN6O3/c1-13(32)31-9-4-10-34-19-11-14(7-8-18(19)31)28-23-27-12-16(24)21(30-23)29-20-15(22(33)26-2)5-3-6-17(20)25/h3,5-8,11-12H,4,9-10H2,1-2H3,(H,26,33)(H2,27,28,29,30)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	28	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc. Curated by ChEMBL					Assay Description Inhibition of c-Met cytoplasmic domain expressed in baculovirus after 30 mins by time-resolved fluorescence assay				Bioorg Med Chem Lett 21: 660-3 (2011) Article DOI: 10.1016/j.bmcl.2010.12.013 BindingDB Entry DOI: 10.7270/Q2RB74WV
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50333570 (2-[2-(9-Acetyl-6,7,8,9-tetrahydro-5-oxa-9-aza-benz...) Show SMILES CNC(=O)c1cccc(F)c1Nc1nc(Nc2ccc3N(CCCOc3c2)C(C)=O)ncc1Cl Show InChI InChI=1S/C23H22ClFN6O3/c1-13(32)31-9-4-10-34-19-11-14(7-8-18(19)31)28-23-27-12-16(24)21(30-23)29-20-15(22(33)26-2)5-3-6-17(20)25/h3,5-8,11-12H,4,9-10H2,1-2H3,(H,26,33)(H2,27,28,29,30)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc. Curated by ChEMBL					Assay Description Inhibition of c-Met expressed in human GTL-16 cells after 2 hrs				Bioorg Med Chem Lett 21: 660-3 (2011) Article DOI: 10.1016/j.bmcl.2010.12.013 BindingDB Entry DOI: 10.7270/Q2RB74WV
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50379190 (CHEMBL2010875) Show SMILES COc1ccnc(Nc2ccc3n(CC(C)C)c4c5CCc6nn(C)cc6-c5c5C(=O)NCc5c4c3c2)n1 Show InChI InChI=1S/C29H29N7O2/c1-15(2)13-36-22-8-5-16(32-29-30-10-9-23(33-29)38-4)11-18(22)25-19-12-31-28(37)26(19)24-17(27(25)36)6-7-21-20(24)14-35(3)34-21/h5,8-11,14-15H,6-7,12-13H2,1-4H3,(H,31,37)(H,30,32,33)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	32	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc. Curated by ChEMBL					Assay Description Inhibition of human recombinant VEGF-R2 expressed in baculovirus expression system using GST-PLCgamma as substrate after 1 hr by time-resolved fluore...				J Med Chem 55: 903-13 (2012) Article DOI: 10.1021/jm201449n BindingDB Entry DOI: 10.7270/Q2ZS2XHW
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50333562 (3-[5-Chloro-4-(2-fluoro-6-methylcarbamoyl-phenylam...) Show SMILES CNC(=O)c1cccc(F)c1Nc1nc(Nc2ccc3N(CCCOc3c2)C(=O)OC)ncc1Cl Show InChI InChI=1S/C23H22ClFN6O4/c1-26-21(32)14-5-3-6-16(25)19(14)29-20-15(24)12-27-22(30-20)28-13-7-8-17-18(11-13)35-10-4-9-31(17)23(33)34-2/h3,5-8,11-12H,4,9-10H2,1-2H3,(H,26,32)(H2,27,28,29,30)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	32	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc. Curated by ChEMBL					Assay Description Inhibition of c-Met cytoplasmic domain expressed in baculovirus after 30 mins by time-resolved fluorescence assay				Bioorg Med Chem Lett 21: 660-3 (2011) Article DOI: 10.1016/j.bmcl.2010.12.013 BindingDB Entry DOI: 10.7270/Q2RB74WV
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50333563 (3-[5-Chloro-4-(2-fluoro-6-methylcarbamoyl-phenylam...) Show SMILES CCOC(=O)N1CCCOc2cc(Nc3ncc(Cl)c(Nc4c(F)cccc4C(=O)NC)n3)ccc12 Show InChI InChI=1S/C24H24ClFN6O4/c1-3-35-24(34)32-10-5-11-36-19-12-14(8-9-18(19)32)29-23-28-13-16(25)21(31-23)30-20-15(22(33)27-2)6-4-7-17(20)26/h4,6-9,12-13H,3,5,10-11H2,1-2H3,(H,27,33)(H2,28,29,30,31)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	36	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc. Curated by ChEMBL					Assay Description Inhibition of c-Met expressed in human GTL-16 cells after 2 hrs				Bioorg Med Chem Lett 21: 660-3 (2011) Article DOI: 10.1016/j.bmcl.2010.12.013 BindingDB Entry DOI: 10.7270/Q2RB74WV
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM50379186 (CEP-11981 | CHEMBL2010872) Show SMILES CC(C)Cn1c2ccc(Nc3ncccn3)cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12 Show InChI InChI=1S/C28H27N7O/c1-15(2)13-35-22-8-5-16(32-28-29-9-4-10-30-28)11-18(22)24-19-12-31-27(36)25(19)23-17(26(24)35)6-7-21-20(23)14-34(3)33-21/h4-5,8-11,14-15H,6-7,12-13H2,1-3H3,(H,31,36)(H,29,30,32)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	37	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc. Curated by ChEMBL					Assay Description Inhibition of human cSrc using ATP as substrate				J Med Chem 55: 903-13 (2012) Article DOI: 10.1021/jm201449n BindingDB Entry DOI: 10.7270/Q2ZS2XHW
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50333558 (2-{5-Chloro-2-[3-(2-methoxy-ethyl)-2,3,4,5-tetrahy...) Show SMILES CNC(=O)c1ccccc1Nc1nc(Nc2ccc3CCN(CCOC)CCc3c2)ncc1Cl Show InChI InChI=1S/C25H29ClN6O2/c1-27-24(33)20-5-3-4-6-22(20)30-23-21(26)16-28-25(31-23)29-19-8-7-17-9-11-32(13-14-34-2)12-10-18(17)15-19/h3-8,15-16H,9-14H2,1-2H3,(H,27,33)(H2,28,29,30,31)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	41	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc. Curated by ChEMBL					Assay Description Inhibition of c-Met cytoplasmic domain expressed in baculovirus after 30 mins by time-resolved fluorescence assay				Bioorg Med Chem Lett 21: 660-3 (2011) Article DOI: 10.1016/j.bmcl.2010.12.013 BindingDB Entry DOI: 10.7270/Q2RB74WV
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50333574 (2-[5-Chloro-2-(9-ethyl-6,7,8,9-tetrahydro-5-oxa-9-...) Show SMILES CCN1CCCOc2ccc(Nc3ncc(Cl)c(Nc4c(F)cccc4C(=O)NC)n3)cc12 Show InChI InChI=1S/C23H24ClFN6O2/c1-3-31-10-5-11-33-19-9-8-14(12-18(19)31)28-23-27-13-16(24)21(30-23)29-20-15(22(32)26-2)6-4-7-17(20)25/h4,6-9,12-13H,3,5,10-11H2,1-2H3,(H,26,32)(H2,27,28,29,30)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	41	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc. Curated by ChEMBL					Assay Description Inhibition of c-Met expressed in human GTL-16 cells after 2 hrs				Bioorg Med Chem Lett 21: 660-3 (2011) Article DOI: 10.1016/j.bmcl.2010.12.013 BindingDB Entry DOI: 10.7270/Q2RB74WV
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50333569 (2-[5-Chloro-2-(6,7,8,9-tetrahydro-5-oxa-9-aza-benz...) Show SMILES CNC(=O)c1cccc(F)c1Nc1nc(Nc2ccc3NCCCOc3c2)ncc1Cl Show InChI InChI=1S/C21H20ClFN6O2/c1-24-20(30)13-4-2-5-15(23)18(13)28-19-14(22)11-26-21(29-19)27-12-6-7-16-17(10-12)31-9-3-8-25-16/h2,4-7,10-11,25H,3,8-9H2,1H3,(H,24,30)(H2,26,27,28,29)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	42	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc. Curated by ChEMBL					Assay Description Inhibition of c-Met cytoplasmic domain expressed in baculovirus after 30 mins by time-resolved fluorescence assay				Bioorg Med Chem Lett 21: 660-3 (2011) Article DOI: 10.1016/j.bmcl.2010.12.013 BindingDB Entry DOI: 10.7270/Q2RB74WV
					More data for this Ligand-Target Pair
Aurora kinase A (Homo sapiens (Human))	BDBM50379186 (CEP-11981 | CHEMBL2010872) Show SMILES CC(C)Cn1c2ccc(Nc3ncccn3)cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12 Show InChI InChI=1S/C28H27N7O/c1-15(2)13-35-22-8-5-16(32-28-29-9-4-10-30-28)11-18(22)24-19-12-31-27(36)25(19)23-17(26(24)35)6-7-21-20(23)14-34(3)33-21/h4-5,8-11,14-15H,6-7,12-13H2,1-3H3,(H,31,36)(H,29,30,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	42	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc. Curated by ChEMBL					Assay Description Inhibition of human Aurora-A using ATP as substrate				J Med Chem 55: 903-13 (2012) Article DOI: 10.1021/jm201449n BindingDB Entry DOI: 10.7270/Q2ZS2XHW
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50333571 (2-{5-Chloro-2-[9-(2-pyrrolidin-1-yl-acetyl)-6,7,8,...) Show SMILES CNC(=O)c1cccc(F)c1Nc1nc(Nc2ccc3N(CCCOc3c2)C(=O)CN2CCCC2)ncc1Cl Show InChI InChI=1S/C27H29ClFN7O3/c1-30-26(38)18-6-4-7-20(29)24(18)33-25-19(28)15-31-27(34-25)32-17-8-9-21-22(14-17)39-13-5-12-36(21)23(37)16-35-10-2-3-11-35/h4,6-9,14-15H,2-3,5,10-13,16H2,1H3,(H,30,38)(H2,31,32,33,34)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	44	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc. Curated by ChEMBL					Assay Description Inhibition of c-Met cytoplasmic domain expressed in baculovirus after 30 mins by time-resolved fluorescence assay				Bioorg Med Chem Lett 21: 660-3 (2011) Article DOI: 10.1016/j.bmcl.2010.12.013 BindingDB Entry DOI: 10.7270/Q2RB74WV
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50333566 (3-[5-Chloro-4-(2-fluoro-6-methylcarbamoyl-phenylam...) Show SMILES CNC(=O)c1cccc(F)c1Nc1nc(Nc2ccc3N(CCCOc3c2)C(=O)OCCCN(C)C)ncc1Cl Show InChI InChI=1S/C27H31ClFN7O4/c1-30-25(37)18-7-4-8-20(29)23(18)33-24-19(28)16-31-26(34-24)32-17-9-10-21-22(15-17)39-13-6-12-36(21)27(38)40-14-5-11-35(2)3/h4,7-10,15-16H,5-6,11-14H2,1-3H3,(H,30,37)(H2,31,32,33,34)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	45	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc. Curated by ChEMBL					Assay Description Inhibition of c-Met cytoplasmic domain expressed in baculovirus after 30 mins by time-resolved fluorescence assay				Bioorg Med Chem Lett 21: 660-3 (2011) Article DOI: 10.1016/j.bmcl.2010.12.013 BindingDB Entry DOI: 10.7270/Q2RB74WV
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50333562 (3-[5-Chloro-4-(2-fluoro-6-methylcarbamoyl-phenylam...) Show SMILES CNC(=O)c1cccc(F)c1Nc1nc(Nc2ccc3N(CCCOc3c2)C(=O)OC)ncc1Cl Show InChI InChI=1S/C23H22ClFN6O4/c1-26-21(32)14-5-3-6-16(25)19(14)29-20-15(24)12-27-22(30-20)28-13-7-8-17-18(11-13)35-10-4-9-31(17)23(33)34-2/h3,5-8,11-12H,4,9-10H2,1-2H3,(H,26,32)(H2,27,28,29,30)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	46	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc. Curated by ChEMBL					Assay Description Inhibition of c-Met expressed in human GTL-16 cells after 2 hrs				Bioorg Med Chem Lett 21: 660-3 (2011) Article DOI: 10.1016/j.bmcl.2010.12.013 BindingDB Entry DOI: 10.7270/Q2RB74WV
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50333564 (3-[5-Chloro-4-(2-fluoro-6-methylcarbamoyl-phenylam...) Show SMILES CNC(=O)c1cccc(F)c1Nc1nc(Nc2ccc3N(CCCOc3c2)C(=O)OC(C)C)ncc1Cl Show InChI InChI=1S/C25H26ClFN6O4/c1-14(2)37-25(35)33-10-5-11-36-20-12-15(8-9-19(20)33)30-24-29-13-17(26)22(32-24)31-21-16(23(34)28-3)6-4-7-18(21)27/h4,6-9,12-14H,5,10-11H2,1-3H3,(H,28,34)(H2,29,30,31,32)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	47	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc. Curated by ChEMBL					Assay Description Inhibition of c-Met cytoplasmic domain expressed in baculovirus after 30 mins by time-resolved fluorescence assay				Bioorg Med Chem Lett 21: 660-3 (2011) Article DOI: 10.1016/j.bmcl.2010.12.013 BindingDB Entry DOI: 10.7270/Q2RB74WV
					More data for this Ligand-Target Pair
Casein kinase I isoform alpha (Homo sapiens (Human))	BDBM50379186 (CEP-11981 | CHEMBL2010872) Show SMILES CC(C)Cn1c2ccc(Nc3ncccn3)cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12 Show InChI InChI=1S/C28H27N7O/c1-15(2)13-35-22-8-5-16(32-28-29-9-4-10-30-28)11-18(22)24-19-12-31-27(36)25(19)23-17(26(24)35)6-7-21-20(23)14-34(3)33-21/h4-5,8-11,14-15H,6-7,12-13H2,1-3H3,(H,31,36)(H,29,30,32)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	48	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc. Curated by ChEMBL					Assay Description Inhibition of CK1 using ATP as substrate				J Med Chem 55: 903-13 (2012) Article DOI: 10.1021/jm201449n BindingDB Entry DOI: 10.7270/Q2ZS2XHW
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50333575 (2-[2-(9-Acetyl-6,7,8,9-tetrahydro-5-oxa-9-aza-benz...) Show SMILES CNC(=O)c1cccc(F)c1Nc1nc(Nc2ccc3OCCCN(C(C)=O)c3c2)ncc1Cl Show InChI InChI=1S/C23H22ClFN6O3/c1-13(32)31-9-4-10-34-19-8-7-14(11-18(19)31)28-23-27-12-16(24)21(30-23)29-20-15(22(33)26-2)5-3-6-17(20)25/h3,5-8,11-12H,4,9-10H2,1-2H3,(H,26,33)(H2,27,28,29,30)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	49	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc. Curated by ChEMBL					Assay Description Inhibition of c-Met expressed in human GTL-16 cells after 2 hrs				Bioorg Med Chem Lett 21: 660-3 (2011) Article DOI: 10.1016/j.bmcl.2010.12.013 BindingDB Entry DOI: 10.7270/Q2RB74WV
					More data for this Ligand-Target Pair

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