Compile Data Set for Download or QSAR

Found 62 hits with Last Name = 'peachey' and Initial = 'je'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2 (Homo sapiens (Human))	BDBM50157959 (5-Chloro-thiophene-2-sulfonic acid [5-((E)-3-morph...) Show SMILES Clc1ccc(s1)S(=O)(=O)NC1C2CCC1Cc1cc(\C=C\CN3CCOCC3)ccc1C2 |THB:17:16:10:12.13,9:10:16.30.15.31:12.13,29:30:10:12.13| Show InChI InChI=1S/C24H29ClN2O3S2/c25-22-7-8-23(31-22)32(28,29)26-24-19-5-6-20(24)16-21-14-17(3-4-18(21)15-19)2-1-9-27-10-12-30-13-11-27/h1-4,7-8,14,19-20,24,26H,5-6,9-13,15-16H2/b2-1+	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Research Laboratories Curated by ChEMBL					Assay Description Inhibitory concentration against Gamma-secretase in whole cell inhibition assay using SH-SY5Y cells				Bioorg Med Chem Lett 15: 373-8 (2004) Article DOI: 10.1016/j.bmcl.2004.10.062 BindingDB Entry DOI: 10.7270/Q2445KZQ
					More data for this Ligand-Target Pair
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2 (Homo sapiens (Human))	BDBM50158012 (CHEMBL183351 | N-[13-(5-Chloro-thiophene-2-sulfony...) Show SMILES Clc1ccc(s1)S(=O)(=O)NC1C2CCC1Cc1cc(NC(=O)CN3CCN(CC3)c3ccccc3)ccc1C2 |THB:9:10:16.37.15.38:13.12,17:16:10:13.12,36:37:10:13.12| Show InChI InChI=1S/C29H33ClN4O3S2/c30-26-10-11-28(38-26)39(36,37)32-29-21-6-7-22(29)17-23-18-24(9-8-20(23)16-21)31-27(35)19-33-12-14-34(15-13-33)25-4-2-1-3-5-25/h1-5,8-11,18,21-22,29,32H,6-7,12-17,19H2,(H,31,35)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Research Laboratories Curated by ChEMBL					Assay Description Inhibitory concentration against Gamma-secretase in whole cell inhibition assay using SH-SY5Y cells				Bioorg Med Chem Lett 15: 373-8 (2004) Article DOI: 10.1016/j.bmcl.2004.10.062 BindingDB Entry DOI: 10.7270/Q2445KZQ
					More data for this Ligand-Target Pair
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2 (Homo sapiens (Human))	BDBM50157998 (5-Chloro-thiophene-2-sulfonic acid [5-(2-morpholin...) Show SMILES Clc1ccc(s1)S(=O)(=O)NC1C2CCC1Cc1cc(OCCN3CCOCC3)ccc1C2 |THB:17:16:10:13.12,9:10:16.30.15.31:13.12,29:30:10:13.12| Show InChI InChI=1S/C23H29ClN2O4S2/c24-21-5-6-22(31-21)32(27,28)25-23-17-1-2-18(23)14-19-15-20(4-3-16(19)13-17)30-12-9-26-7-10-29-11-8-26/h3-6,15,17-18,23,25H,1-2,7-14H2	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Research Laboratories Curated by ChEMBL					Assay Description Inhibitory concentration against Gamma-secretase in whole cell inhibition assay using SH-SY5Y cells				Bioorg Med Chem Lett 15: 373-8 (2004) Article DOI: 10.1016/j.bmcl.2004.10.062 BindingDB Entry DOI: 10.7270/Q2445KZQ
					More data for this Ligand-Target Pair
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2 (Homo sapiens (Human))	BDBM50157959 (5-Chloro-thiophene-2-sulfonic acid [5-((E)-3-morph...) Show SMILES Clc1ccc(s1)S(=O)(=O)NC1C2CCC1Cc1cc(\C=C\CN3CCOCC3)ccc1C2 |THB:17:16:10:12.13,9:10:16.30.15.31:12.13,29:30:10:12.13| Show InChI InChI=1S/C24H29ClN2O3S2/c25-22-7-8-23(31-22)32(28,29)26-24-19-5-6-20(24)16-21-14-17(3-4-18(21)15-19)2-1-9-27-10-12-30-13-11-27/h1-4,7-8,14,19-20,24,26H,5-6,9-13,15-16H2/b2-1+	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Research Laboratories Curated by ChEMBL					Assay Description Inhibitory concentration against Gamma-secretase in whole cell inhibition assay using SH-SY5Y cells				Bioorg Med Chem Lett 15: 373-8 (2004) Article DOI: 10.1016/j.bmcl.2004.10.062 BindingDB Entry DOI: 10.7270/Q2445KZQ
					More data for this Ligand-Target Pair
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2 (Homo sapiens (Human))	BDBM50157959 (5-Chloro-thiophene-2-sulfonic acid [5-((E)-3-morph...) Show SMILES Clc1ccc(s1)S(=O)(=O)NC1C2CCC1Cc1cc(\C=C\CN3CCOCC3)ccc1C2 |THB:17:16:10:12.13,9:10:16.30.15.31:12.13,29:30:10:12.13| Show InChI InChI=1S/C24H29ClN2O3S2/c25-22-7-8-23(31-22)32(28,29)26-24-19-5-6-20(24)16-21-14-17(3-4-18(21)15-19)2-1-9-27-10-12-30-13-11-27/h1-4,7-8,14,19-20,24,26H,5-6,9-13,15-16H2/b2-1+	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Research Laboratories Curated by ChEMBL					Assay Description Inhibitory concentration against Gamma-secretase in whole cell inhibition assay using SH-SY5Y cells				Bioorg Med Chem Lett 15: 373-8 (2004) Article DOI: 10.1016/j.bmcl.2004.10.062 BindingDB Entry DOI: 10.7270/Q2445KZQ
					More data for this Ligand-Target Pair
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2 (Homo sapiens (Human))	BDBM50158017 (CHEMBL180384 | N-[13-(5-Chloro-thiophene-2-sulfony...) Show SMILES Clc1ccc(s1)S(=O)(=O)NC1C2CCC1Cc1cc(NC(=O)CN3CCCCC3)ccc1C2 |THB:17:16:10:13.12,9:10:16.31.15.32:13.12,30:31:10:13.12| Show InChI InChI=1S/C24H30ClN3O3S2/c25-21-8-9-23(32-21)33(30,31)27-24-17-4-5-18(24)13-19-14-20(7-6-16(19)12-17)26-22(29)15-28-10-2-1-3-11-28/h6-9,14,17-18,24,27H,1-5,10-13,15H2,(H,26,29)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Research Laboratories Curated by ChEMBL					Assay Description Inhibitory concentration against Gamma-secretase in whole cell inhibition assay using SH-SY5Y cells				Bioorg Med Chem Lett 15: 373-8 (2004) Article DOI: 10.1016/j.bmcl.2004.10.062 BindingDB Entry DOI: 10.7270/Q2445KZQ
					More data for this Ligand-Target Pair
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2 (Homo sapiens (Human))	BDBM50158000 (CHEMBL183774 | N-[13-(5-Chloro-thiophene-2-sulfony...) Show SMILES Clc1ccc(s1)S(=O)(=O)NC1C2CCC1Cc1cc(NC(=O)CN3CCOCC3)ccc1C2 |THB:17:16:10:13.12,9:10:16.31.15.32:13.12,30:31:10:13.12| Show InChI InChI=1S/C23H28ClN3O4S2/c24-20-5-6-22(32-20)33(29,30)26-23-16-1-2-17(23)12-18-13-19(4-3-15(18)11-16)25-21(28)14-27-7-9-31-10-8-27/h3-6,13,16-17,23,26H,1-2,7-12,14H2,(H,25,28)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Research Laboratories Curated by ChEMBL					Assay Description Inhibitory concentration against Gamma-secretase in whole cell inhibition assay using SH-SY5Y cells				Bioorg Med Chem Lett 15: 373-8 (2004) Article DOI: 10.1016/j.bmcl.2004.10.062 BindingDB Entry DOI: 10.7270/Q2445KZQ
					More data for this Ligand-Target Pair
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2 (Homo sapiens (Human))	BDBM50157983 (CHEMBL183558 | N-[13-(5-Chloro-thiophene-2-sulfony...) Show SMILES Clc1ccc(s1)S(=O)(=O)NC1C2CCC1Cc1cc(NC(=O)CN3CCCC3)ccc1C2 |THB:17:16:10:13.12,9:10:16.30.15.31:13.12,29:30:10:13.12| Show InChI InChI=1S/C23H28ClN3O3S2/c24-20-7-8-22(31-20)32(29,30)26-23-16-3-4-17(23)12-18-13-19(6-5-15(18)11-16)25-21(28)14-27-9-1-2-10-27/h5-8,13,16-17,23,26H,1-4,9-12,14H2,(H,25,28)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Research Laboratories Curated by ChEMBL					Assay Description Inhibitory concentration against Gamma-secretase in whole cell inhibition assay using SH-SY5Y cells				Bioorg Med Chem Lett 15: 373-8 (2004) Article DOI: 10.1016/j.bmcl.2004.10.062 BindingDB Entry DOI: 10.7270/Q2445KZQ
					More data for this Ligand-Target Pair
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2 (Homo sapiens (Human))	BDBM50157994 (CHEMBL183764 | Pyridine-2-carboxylic acid [13-(5-c...) Show SMILES Clc1ccc(s1)S(=O)(=O)NC1C2CCC1Cc1cc(NC(=O)c3ccccn3)ccc1C2 |THB:9:10:16.30.15.31:12.13,17:16:10:12.13,29:30:10:12.13| Show InChI InChI=1S/C23H22ClN3O3S2/c24-20-8-9-21(31-20)32(29,30)27-22-15-4-5-16(22)12-17-13-18(7-6-14(17)11-15)26-23(28)19-3-1-2-10-25-19/h1-3,6-10,13,15-16,22,27H,4-5,11-12H2,(H,26,28)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Research Laboratories Curated by ChEMBL					Assay Description Inhibitory concentration against Gamma-secretase in whole cell inhibition assay using SH-SY5Y cells				Bioorg Med Chem Lett 15: 373-8 (2004) Article DOI: 10.1016/j.bmcl.2004.10.062 BindingDB Entry DOI: 10.7270/Q2445KZQ
					More data for this Ligand-Target Pair
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2 (Homo sapiens (Human))	BDBM50158009 (5-Chloro-thiophene-2-sulfonic acid [5-((E)-3-imida...) Show SMILES Clc1ccc(s1)S(=O)(=O)NC1C2CCC1Cc1cc(\C=C\Cn3ccnc3)ccc1C2 |THB:9:10:16.29.15.30:12.13,17:16:10:12.13,28:29:10:12.13| Show InChI InChI=1S/C23H24ClN3O2S2/c24-21-7-8-22(30-21)31(28,29)26-23-18-5-6-19(23)14-20-12-16(3-4-17(20)13-18)2-1-10-27-11-9-25-15-27/h1-4,7-9,11-12,15,18-19,23,26H,5-6,10,13-14H2/b2-1+	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Research Laboratories Curated by ChEMBL					Assay Description Inhibitory concentration against Gamma-secretase in whole cell inhibition assay using SH-SY5Y cells				Bioorg Med Chem Lett 15: 373-8 (2004) Article DOI: 10.1016/j.bmcl.2004.10.062 BindingDB Entry DOI: 10.7270/Q2445KZQ
					More data for this Ligand-Target Pair
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2 (Homo sapiens (Human))	BDBM50158018 ((13-Benzenesulfonylamino-tricyclo[8.2.1.0*3,8*]tri...) Show SMILES Clc1ccc(COC(=O)Nc2ccc3CC4CCC(Cc3c2)C4NS(=O)(=O)c2ccccc2)cc1 |TLB:12:13:22:16.17,21:20:22:16.17,THB:23:22:20.13.19.14:16.17| Show InChI InChI=1S/C27H27ClN2O4S/c28-23-11-6-18(7-12-23)17-34-27(31)29-24-13-10-19-14-20-8-9-21(15-22(19)16-24)26(20)30-35(32,33)25-4-2-1-3-5-25/h1-7,10-13,16,20-21,26,30H,8-9,14-15,17H2,(H,29,31)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Research Laboratories Curated by ChEMBL					Assay Description Inhibitory concentration against Gamma-secretase in whole cell inhibition assay using SH-SY5Y cells				Bioorg Med Chem Lett 15: 373-8 (2004) Article DOI: 10.1016/j.bmcl.2004.10.062 BindingDB Entry DOI: 10.7270/Q2445KZQ
					More data for this Ligand-Target Pair
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2 (Homo sapiens (Human))	BDBM50157975 (5-Chloro-thiophene-2-sulfonic acid {5-[(E)-3-(4-ph...) Show SMILES Clc1ccc(s1)S(=O)(=O)NC1C2CCC1Cc1cc(\C=C\CN3CCN(CC3)c3ccccc3)ccc1C2 |THB:9:10:16.36.15.37:12.13,17:16:10:12.13,35:36:10:12.13| Show InChI InChI=1S/C30H34ClN3O2S2/c31-28-12-13-29(37-28)38(35,36)32-30-24-10-11-25(30)21-26-19-22(8-9-23(26)20-24)5-4-14-33-15-17-34(18-16-33)27-6-2-1-3-7-27/h1-9,12-13,19,24-25,30,32H,10-11,14-18,20-21H2/b5-4+	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	21	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Research Laboratories Curated by ChEMBL					Assay Description Inhibitory concentration against Gamma-secretase in whole cell inhibition assay using SH-SY5Y cells				Bioorg Med Chem Lett 15: 373-8 (2004) Article DOI: 10.1016/j.bmcl.2004.10.062 BindingDB Entry DOI: 10.7270/Q2445KZQ
					More data for this Ligand-Target Pair
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2 (Homo sapiens (Human))	BDBM50157966 (CHEMBL180784 | [13-(5-Chloro-thiophene-2-sulfonyla...) Show SMILES Clc1ccc(s1)S(=O)(=O)NC1C2CCC1Cc1cc(NC(=O)OCc3ccccc3)ccc1C2 |THB:9:10:16.32.15.33:12.13,17:16:10:12.13,31:32:10:12.13| Show InChI InChI=1S/C25H25ClN2O4S2/c26-22-10-11-23(33-22)34(30,31)28-24-18-6-7-19(24)13-20-14-21(9-8-17(20)12-18)27-25(29)32-15-16-4-2-1-3-5-16/h1-5,8-11,14,18-19,24,28H,6-7,12-13,15H2,(H,27,29)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	23	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Research Laboratories Curated by ChEMBL					Assay Description Inhibitory concentration against Gamma-secretase in whole cell inhibition assay using SH-SY5Y cells				Bioorg Med Chem Lett 15: 373-8 (2004) Article DOI: 10.1016/j.bmcl.2004.10.062 BindingDB Entry DOI: 10.7270/Q2445KZQ
					More data for this Ligand-Target Pair
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2 (Homo sapiens (Human))	BDBM50158010 (5-Chloro-thiophene-2-sulfonic acid (5-fluoro-tricy...) Show SMILES Fc1ccc2CC3CCC(Cc2c1)C3NS(=O)(=O)c1ccc(Cl)s1 |TLB:12:11:13:8.7,3:4:13:8.7,THB:14:13:11.4.10.5:8.7| Show InChI InChI=1S/C17H17ClFNO2S2/c18-15-5-6-16(23-15)24(21,22)20-17-11-1-2-12(17)8-13-9-14(19)4-3-10(13)7-11/h3-6,9,11-12,17,20H,1-2,7-8H2	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	29	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Research Laboratories Curated by ChEMBL					Assay Description Inhibitory concentration against Gamma-secretase in whole cell inhibition assay using SH-SY5Y cells				Bioorg Med Chem Lett 15: 373-8 (2004) Article DOI: 10.1016/j.bmcl.2004.10.062 BindingDB Entry DOI: 10.7270/Q2445KZQ
					More data for this Ligand-Target Pair
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2 (Homo sapiens (Human))	BDBM50157965 (5-Chloro-thiophene-2-sulfonic acid (4-fluoro-tricy...) Show SMILES Fc1cccc2CC3CCC(Cc12)C3NS(=O)(=O)c1ccc(Cl)s1 |TLB:1:12:13:9.8,4:5:13:9.8,THB:14:13:12.11.5.6:9.8| Show InChI InChI=1S/C17H17ClFNO2S2/c18-15-6-7-16(23-15)24(21,22)20-17-11-4-5-12(17)9-13-10(8-11)2-1-3-14(13)19/h1-3,6-7,11-12,17,20H,4-5,8-9H2	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	34	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Research Laboratories Curated by ChEMBL					Assay Description Inhibitory concentration against Gamma-secretase in whole cell inhibition assay using SH-SY5Y cells				Bioorg Med Chem Lett 15: 373-8 (2004) Article DOI: 10.1016/j.bmcl.2004.10.062 BindingDB Entry DOI: 10.7270/Q2445KZQ
					More data for this Ligand-Target Pair
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2 (Homo sapiens (Human))	BDBM50158008 (5-Chloro-thiophene-2-sulfonic acid {5-[(E)-3-(4-me...) Show SMILES CN1CCN(C\C=C\c2ccc3CC4CCC(Cc3c2)C4NS(=O)(=O)c2ccc(Cl)s2)CC1 |TLB:19:18:20:15.14,10:11:20:15.14,THB:21:20:18.11.17.12:15.14| Show InChI InChI=1S/C25H32ClN3O2S2/c1-28-11-13-29(14-12-28)10-2-3-18-4-5-19-16-20-6-7-21(17-22(19)15-18)25(20)27-33(30,31)24-9-8-23(26)32-24/h2-5,8-9,15,20-21,25,27H,6-7,10-14,16-17H2,1H3/b3-2+	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	39	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Research Laboratories Curated by ChEMBL					Assay Description Inhibitory concentration against Gamma-secretase in whole cell inhibition assay using SH-SY5Y cells				Bioorg Med Chem Lett 15: 373-8 (2004) Article DOI: 10.1016/j.bmcl.2004.10.062 BindingDB Entry DOI: 10.7270/Q2445KZQ
					More data for this Ligand-Target Pair
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2 (Homo sapiens (Human))	BDBM50157984 (CHEMBL182349 | N-[13-(5-Chloro-thiophene-2-sulfony...) Show SMILES CCN(CC)CC(=O)Nc1ccc2CC3CCC(Cc2c1)C3NS(=O)(=O)c1ccc(Cl)s1 |TLB:20:19:21:16.15,11:12:21:16.15,THB:22:21:19.12.18.13:16.15| Show InChI InChI=1S/C23H30ClN3O3S2/c1-3-27(4-2)14-21(28)25-19-8-7-15-11-16-5-6-17(12-18(15)13-19)23(16)26-32(29,30)22-10-9-20(24)31-22/h7-10,13,16-17,23,26H,3-6,11-12,14H2,1-2H3,(H,25,28)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	41	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Research Laboratories Curated by ChEMBL					Assay Description Inhibitory concentration against Gamma-secretase in whole cell inhibition assay using SH-SY5Y cells				Bioorg Med Chem Lett 15: 373-8 (2004) Article DOI: 10.1016/j.bmcl.2004.10.062 BindingDB Entry DOI: 10.7270/Q2445KZQ
					More data for this Ligand-Target Pair
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2 (Homo sapiens (Human))	BDBM50157977 (CHEMBL183654 | Thiophene-2-sulfonic acid tricyclo[...) Show SMILES O=S(=O)(NC1C2CCC1Cc1ccccc1C2)c1cccs1 |THB:3:4:16.9.10.15:6.7,14:15:4:6.7,11:10:4:6.7| Show InChI InChI=1S/C17H19NO2S2/c19-22(20,16-6-3-9-21-16)18-17-14-7-8-15(17)11-13-5-2-1-4-12(13)10-14/h1-6,9,14-15,17-18H,7-8,10-11H2	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	50	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Research Laboratories Curated by ChEMBL					Assay Description Inhibitory concentration against Gamma-secretase in whole cell inhibition assay using SH-SY5Y cells				Bioorg Med Chem Lett 15: 373-8 (2004) Article DOI: 10.1016/j.bmcl.2004.10.062 BindingDB Entry DOI: 10.7270/Q2445KZQ
					More data for this Ligand-Target Pair
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2 (Homo sapiens (Human))	BDBM50157973 (5-chloro-thiophene-2-sulfonic acid tricyclo[8.2.1....) Show SMILES Clc1ccc(s1)S(=O)(=O)NC1C2CCC1Cc1ccccc1C2 |THB:17:16:10:12.13,9:10:22.15.16.21:12.13,20:21:10:12.13| Show InChI InChI=1S/C17H18ClNO2S2/c18-15-7-8-16(22-15)23(20,21)19-17-13-5-6-14(17)10-12-4-2-1-3-11(12)9-13/h1-4,7-8,13-14,17,19H,5-6,9-10H2	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	62	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Research Laboratories Curated by ChEMBL					Assay Description Inhibitory concentration against Gamma-secretase in whole cell inhibition assay using SH-SY5Y cells				Bioorg Med Chem Lett 15: 373-8 (2004) Article DOI: 10.1016/j.bmcl.2004.10.062 BindingDB Entry DOI: 10.7270/Q2445KZQ
					More data for this Ligand-Target Pair
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2 (Homo sapiens (Human))	BDBM50157960 (CHEMBL362644 | N-[13-(5-Chloro-thiophene-2-sulfony...) Show SMILES CN1CCN(CC(=O)Nc2ccc3CC4CCC(Cc3c2)C4NS(=O)(=O)c2ccc(Cl)s2)CC1 |TLB:20:19:21:15.16,11:12:21:15.16,THB:22:21:19.12.18.13:15.16| Show InChI InChI=1S/C24H31ClN4O3S2/c1-28-8-10-29(11-9-28)15-22(30)26-20-5-4-16-12-17-2-3-18(13-19(16)14-20)24(17)27-34(31,32)23-7-6-21(25)33-23/h4-7,14,17-18,24,27H,2-3,8-13,15H2,1H3,(H,26,30)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	69	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Research Laboratories Curated by ChEMBL					Assay Description Inhibitory concentration against Gamma-secretase in whole cell inhibition assay using SH-SY5Y cells				Bioorg Med Chem Lett 15: 373-8 (2004) Article DOI: 10.1016/j.bmcl.2004.10.062 BindingDB Entry DOI: 10.7270/Q2445KZQ
					More data for this Ligand-Target Pair
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2 (Homo sapiens (Human))	BDBM50157991 (CHEMBL183449 | N-(5-Fluoro-tricyclo[8.2.1.0*3,8*]t...) Show SMILES Fc1ccc2CC3CCC(Cc2c1)C3NS(=O)(=O)c1ccccc1 |TLB:12:11:13:8.7,3:4:13:8.7,THB:14:13:11.4.10.5:8.7| Show InChI InChI=1S/C19H20FNO2S/c20-17-9-8-13-10-14-6-7-15(11-16(13)12-17)19(14)21-24(22,23)18-4-2-1-3-5-18/h1-5,8-9,12,14-15,19,21H,6-7,10-11H2	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	70	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Research Laboratories Curated by ChEMBL					Assay Description Inhibitory concentration against Gamma-secretase in whole cell inhibition assay using SH-SY5Y cells				Bioorg Med Chem Lett 15: 373-8 (2004) Article DOI: 10.1016/j.bmcl.2004.10.062 BindingDB Entry DOI: 10.7270/Q2445KZQ
					More data for this Ligand-Target Pair
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2 (Homo sapiens (Human))	BDBM50158003 (5-Chloro-thiophene-2-sulfonic acid [5-(2-piperidin...) Show SMILES Clc1ccc(s1)S(=O)(=O)NC1C2CCC1Cc1cc(OCCN3CCCCC3)ccc1C2 |THB:17:16:10:13.12,9:10:16.30.15.31:13.12,29:30:10:13.12| Show InChI InChI=1S/C24H31ClN2O3S2/c25-22-8-9-23(31-22)32(28,29)26-24-18-4-5-19(24)15-20-16-21(7-6-17(20)14-18)30-13-12-27-10-2-1-3-11-27/h6-9,16,18-19,24,26H,1-5,10-15H2	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	73	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Research Laboratories Curated by ChEMBL					Assay Description Inhibitory concentration against Gamma-secretase in whole cell inhibition assay using SH-SY5Y cells				Bioorg Med Chem Lett 15: 373-8 (2004) Article DOI: 10.1016/j.bmcl.2004.10.062 BindingDB Entry DOI: 10.7270/Q2445KZQ
					More data for this Ligand-Target Pair
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2 (Homo sapiens (Human))	BDBM50158007 ((13-Benzenesulfonylamino-tricyclo[8.2.1.0*3,8*]tri...) Show SMILES O=C(Nc1ccc2CC3CCC(Cc2c1)C3NS(=O)(=O)c1ccccc1)OCc1ccccc1 |TLB:5:6:15:9.10,14:13:15:9.10,THB:16:15:13.6.12.7:9.10| Show InChI InChI=1S/C27H28N2O4S/c30-27(33-18-19-7-3-1-4-8-19)28-24-14-13-20-15-21-11-12-22(16-23(20)17-24)26(21)29-34(31,32)25-9-5-2-6-10-25/h1-10,13-14,17,21-22,26,29H,11-12,15-16,18H2,(H,28,30)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	74	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Research Laboratories Curated by ChEMBL					Assay Description Inhibitory concentration against Gamma-secretase in whole cell inhibition assay using SH-SY5Y cells				Bioorg Med Chem Lett 15: 373-8 (2004) Article DOI: 10.1016/j.bmcl.2004.10.062 BindingDB Entry DOI: 10.7270/Q2445KZQ
					More data for this Ligand-Target Pair
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2 (Homo sapiens (Human))	BDBM50157972 (CHEMBL183585 | Pyridine-2-carboxylic acid (13-benz...) Show SMILES O=C(Nc1ccc2CC3CCC(Cc2c1)C3NS(=O)(=O)c1ccccc1)c1ccccn1 |TLB:14:13:15:9.10,5:6:15:9.10,THB:16:15:13.6.12.7:9.10| Show InChI InChI=1S/C25H25N3O3S/c29-25(23-8-4-5-13-26-23)27-21-12-11-17-14-18-9-10-19(15-20(17)16-21)24(18)28-32(30,31)22-6-2-1-3-7-22/h1-8,11-13,16,18-19,24,28H,9-10,14-15H2,(H,27,29)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	75	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Research Laboratories Curated by ChEMBL					Assay Description Inhibitory concentration against Gamma-secretase in whole cell inhibition assay using SH-SY5Y cells				Bioorg Med Chem Lett 15: 373-8 (2004) Article DOI: 10.1016/j.bmcl.2004.10.062 BindingDB Entry DOI: 10.7270/Q2445KZQ
					More data for this Ligand-Target Pair
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2 (Homo sapiens (Human))	BDBM50157978 (4-Fluoro-N-tricyclo[8.2.1.0*3,8*]trideca-3(8),4,6-...) Show SMILES Fc1ccc(cc1)S(=O)(=O)NC1C2CCC1Cc1ccccc1C2 |THB:10:11:23.16.17.22:13.14,18:17:11:13.14,21:22:11:13.14| Show InChI InChI=1S/C19H20FNO2S/c20-17-7-9-18(10-8-17)24(22,23)21-19-15-5-6-16(19)12-14-4-2-1-3-13(14)11-15/h1-4,7-10,15-16,19,21H,5-6,11-12H2	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	129	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Research Laboratories Curated by ChEMBL					Assay Description Inhibitory concentration against Gamma-secretase in whole cell inhibition assay using SH-SY5Y cells				Bioorg Med Chem Lett 15: 373-8 (2004) Article DOI: 10.1016/j.bmcl.2004.10.062 BindingDB Entry DOI: 10.7270/Q2445KZQ
					More data for this Ligand-Target Pair
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2 (Homo sapiens (Human))	BDBM50157988 (5-Chloro-thiophene-2-sulfonic acid (5-chloro-tricy...) Show SMILES Clc1ccc(s1)S(=O)(=O)NC1C2CCC1Cc1cc(Cl)ccc1C2 |THB:17:16:10:13.12,21:22:10:13.12,9:10:16.22.15.23:13.12| Show InChI InChI=1S/C17H17Cl2NO2S2/c18-14-4-3-10-7-11-1-2-12(8-13(10)9-14)17(11)20-24(21,22)16-6-5-15(19)23-16/h3-6,9,11-12,17,20H,1-2,7-8H2	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	146	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Research Laboratories Curated by ChEMBL					Assay Description Inhibitory concentration against Gamma-secretase in whole cell inhibition assay using SH-SY5Y cells				Bioorg Med Chem Lett 15: 373-8 (2004) Article DOI: 10.1016/j.bmcl.2004.10.062 BindingDB Entry DOI: 10.7270/Q2445KZQ
					More data for this Ligand-Target Pair
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2 (Homo sapiens (Human))	BDBM50158016 (5-Chloro-thiophene-2-sulfonic acid [5-((E)-3-piper...) Show SMILES Clc1ccc(s1)S(=O)(=O)NC1C2CCC1Cc1cc(\C=C\CN3CCCCC3)ccc1C2 |THB:17:16:10:12.13,9:10:16.30.15.31:12.13,29:30:10:12.13| Show InChI InChI=1S/C25H31ClN2O2S2/c26-23-10-11-24(31-23)32(29,30)27-25-20-8-9-21(25)17-22-15-18(6-7-19(22)16-20)5-4-14-28-12-2-1-3-13-28/h4-7,10-11,15,20-21,25,27H,1-3,8-9,12-14,16-17H2/b5-4+	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	152	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Research Laboratories Curated by ChEMBL					Assay Description Inhibitory concentration against Gamma-secretase in whole cell inhibition assay using SH-SY5Y cells				Bioorg Med Chem Lett 15: 373-8 (2004) Article DOI: 10.1016/j.bmcl.2004.10.062 BindingDB Entry DOI: 10.7270/Q2445KZQ
					More data for this Ligand-Target Pair
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2 (Homo sapiens (Human))	BDBM50157968 ((13-Benzenesulfonylamino-tricyclo[8.2.1.0*3,8*]tri...) Show SMILES Clc1ccccc1COC(=O)Nc1ccc2CC3CCC(Cc2c1)C3NS(=O)(=O)c1ccccc1 |TLB:14:15:24:18.19,23:22:24:18.19,THB:25:24:22.15.21.16:18.19| Show InChI InChI=1S/C27H27ClN2O4S/c28-25-9-5-4-6-21(25)17-34-27(31)29-23-13-12-18-14-19-10-11-20(15-22(18)16-23)26(19)30-35(32,33)24-7-2-1-3-8-24/h1-9,12-13,16,19-20,26,30H,10-11,14-15,17H2,(H,29,31)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	153	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Research Laboratories Curated by ChEMBL					Assay Description Inhibitory concentration against Gamma-secretase in whole cell inhibition assay using SH-SY5Y cells				Bioorg Med Chem Lett 15: 373-8 (2004) Article DOI: 10.1016/j.bmcl.2004.10.062 BindingDB Entry DOI: 10.7270/Q2445KZQ
					More data for this Ligand-Target Pair
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2 (Homo sapiens (Human))	BDBM50157995 (5-Chloro-thiophene-2-sulfonic acid (4-chloro-tricy...) Show SMILES Clc1ccc(s1)S(=O)(=O)NC1C2CCC1Cc1c(Cl)cccc1C2 |THB:17:16:10:13.12,9:10:16.15.22.23:13.12,21:22:10:13.12| Show InChI InChI=1S/C17H17Cl2NO2S2/c18-14-3-1-2-10-8-11-4-5-12(9-13(10)14)17(11)20-24(21,22)16-7-6-15(19)23-16/h1-3,6-7,11-12,17,20H,4-5,8-9H2	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	175	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Research Laboratories Curated by ChEMBL					Assay Description Inhibitory concentration against Gamma-secretase in whole cell inhibition assay using SH-SY5Y cells				Bioorg Med Chem Lett 15: 373-8 (2004) Article DOI: 10.1016/j.bmcl.2004.10.062 BindingDB Entry DOI: 10.7270/Q2445KZQ
					More data for this Ligand-Target Pair
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2 (Homo sapiens (Human))	BDBM50158004 (CHEMBL183326 | N-Tricyclo[8.2.1.0*3,8*]trideca-3(8...) Show SMILES O=S(=O)(NC1C2CCC1Cc1ccccc1C2)c1ccccc1 |THB:3:4:9.16.15.10:6.7,14:15:4:6.7,11:10:4:6.7| Show InChI InChI=1S/C19H21NO2S/c21-23(22,18-8-2-1-3-9-18)20-19-16-10-11-17(19)13-15-7-5-4-6-14(15)12-16/h1-9,16-17,19-20H,10-13H2	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	190	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Research Laboratories Curated by ChEMBL					Assay Description Inhibitory concentration against Gamma-secretase in whole cell inhibition assay using SH-SY5Y cells				Bioorg Med Chem Lett 15: 373-8 (2004) Article DOI: 10.1016/j.bmcl.2004.10.062 BindingDB Entry DOI: 10.7270/Q2445KZQ
					More data for this Ligand-Target Pair
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2 (Homo sapiens (Human))	BDBM50157969 (5-Chloro-thiophene-2-sulfonic acid {5-[2-(3-hydrox...) Show SMILES OC1CCN(CCOc2ccc3CC4CCC(Cc3c2)C4NS(=O)(=O)c2ccc(Cl)s2)C1 |TLB:19:18:20:15.14,10:11:20:15.14,THB:21:20:18.11.17.12:15.14| Show InChI InChI=1S/C23H29ClN2O4S2/c24-21-5-6-22(31-21)32(28,29)25-23-16-1-2-17(23)12-18-13-20(4-3-15(18)11-16)30-10-9-26-8-7-19(27)14-26/h3-6,13,16-17,19,23,25,27H,1-2,7-12,14H2	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	209	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Research Laboratories Curated by ChEMBL					Assay Description Inhibitory concentration against Gamma-secretase in whole cell inhibition assay using SH-SY5Y cells				Bioorg Med Chem Lett 15: 373-8 (2004) Article DOI: 10.1016/j.bmcl.2004.10.062 BindingDB Entry DOI: 10.7270/Q2445KZQ
					More data for this Ligand-Target Pair
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2 (Homo sapiens (Human))	BDBM50158002 (2-(Benzyl-methyl-amino)-N-[13-(5-chloro-thiophene-...) Show SMILES CN(CC(=O)Nc1ccc2CC3CCC(Cc2c1)C3NS(=O)(=O)c1ccc(Cl)s1)Cc1ccccc1 |TLB:17:16:18:12.13,8:9:18:12.13,THB:19:18:16.9.15.10:12.13| Show InChI InChI=1S/C27H30ClN3O3S2/c1-31(16-18-5-3-2-4-6-18)17-25(32)29-23-10-9-19-13-20-7-8-21(14-22(19)15-23)27(20)30-36(33,34)26-12-11-24(28)35-26/h2-6,9-12,15,20-21,27,30H,7-8,13-14,16-17H2,1H3,(H,29,32)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	226	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Research Laboratories Curated by ChEMBL					Assay Description Inhibitory concentration against Gamma-secretase in whole cell inhibition assay using SH-SY5Y cells				Bioorg Med Chem Lett 15: 373-8 (2004) Article DOI: 10.1016/j.bmcl.2004.10.062 BindingDB Entry DOI: 10.7270/Q2445KZQ
					More data for this Ligand-Target Pair
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2 (Homo sapiens (Human))	BDBM50157963 (5-Chloro-thiophene-2-sulfonic acid {5-[2-(2-methyl...) Show SMILES CC1CCCCN1CCOc1ccc2CC3CCC(Cc2c1)C3NS(=O)(=O)c1ccc(Cl)s1 |TLB:21:20:22:17.16,12:13:22:17.16,THB:23:22:20.13.19.14:17.16| Show InChI InChI=1S/C25H33ClN2O3S2/c1-17-4-2-3-11-28(17)12-13-31-22-8-7-18-14-19-5-6-20(15-21(18)16-22)25(19)27-33(29,30)24-10-9-23(26)32-24/h7-10,16-17,19-20,25,27H,2-6,11-15H2,1H3	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	227	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Research Laboratories Curated by ChEMBL					Assay Description Inhibitory concentration against Gamma-secretase in whole cell inhibition assay using SH-SY5Y cells				Bioorg Med Chem Lett 15: 373-8 (2004) Article DOI: 10.1016/j.bmcl.2004.10.062 BindingDB Entry DOI: 10.7270/Q2445KZQ
					More data for this Ligand-Target Pair
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2 (Homo sapiens (Human))	BDBM50157967 (2-Fluoro-N-tricyclo[8.2.1.0*3,8*]trideca-3(8),4,6-...) Show SMILES Fc1ccccc1S(=O)(=O)NC1C2CCC1Cc1ccccc1C2 |THB:21:22:11:13.14,10:11:16.23.22.17:13.14,18:17:11:13.14| Show InChI InChI=1S/C19H20FNO2S/c20-17-7-3-4-8-18(17)24(22,23)21-19-15-9-10-16(19)12-14-6-2-1-5-13(14)11-15/h1-8,15-16,19,21H,9-12H2	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	239	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Research Laboratories Curated by ChEMBL					Assay Description Inhibitory concentration against Gamma-secretase in whole cell inhibition assay using SH-SY5Y cells				Bioorg Med Chem Lett 15: 373-8 (2004) Article DOI: 10.1016/j.bmcl.2004.10.062 BindingDB Entry DOI: 10.7270/Q2445KZQ
					More data for this Ligand-Target Pair
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2 (Homo sapiens (Human))	BDBM50157976 (5-Chloro-thiophene-2-sulfonic acid (5-hydroxy-tric...) Show SMILES Oc1ccc2CC3CCC(Cc2c1)C3NS(=O)(=O)c1ccc(Cl)s1 |TLB:12:11:13:8.7,3:4:13:8.7,THB:14:13:11.4.10.5:8.7| Show InChI InChI=1S/C17H18ClNO3S2/c18-15-5-6-16(23-15)24(21,22)19-17-11-1-2-12(17)8-13-9-14(20)4-3-10(13)7-11/h3-6,9,11-12,17,19-20H,1-2,7-8H2	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	269	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Research Laboratories Curated by ChEMBL					Assay Description Inhibitory concentration against Gamma-secretase in whole cell inhibition assay using SH-SY5Y cells				Bioorg Med Chem Lett 15: 373-8 (2004) Article DOI: 10.1016/j.bmcl.2004.10.062 BindingDB Entry DOI: 10.7270/Q2445KZQ
					More data for this Ligand-Target Pair
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2 (Homo sapiens (Human))	BDBM50157964 (3-Fluoro-N-tricyclo[8.2.1.0*3,8*]trideca-3(8),4,6-...) Show SMILES Fc1cccc(c1)S(=O)(=O)NC1C2CCC1Cc1ccccc1C2 |THB:10:11:16.23.22.17:13.14,21:22:11:13.14,18:17:11:13.14| Show InChI InChI=1S/C19H20FNO2S/c20-17-6-3-7-18(12-17)24(22,23)21-19-15-8-9-16(19)11-14-5-2-1-4-13(14)10-15/h1-7,12,15-16,19,21H,8-11H2	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	324	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Research Laboratories Curated by ChEMBL					Assay Description Inhibitory concentration against Gamma-secretase in whole cell inhibition assay using SH-SY5Y cells				Bioorg Med Chem Lett 15: 373-8 (2004) Article DOI: 10.1016/j.bmcl.2004.10.062 BindingDB Entry DOI: 10.7270/Q2445KZQ
					More data for this Ligand-Target Pair
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2 (Homo sapiens (Human))	BDBM50157981 (5-Chloro-thiophene-2-sulfonic acid {5-[2-(2-methyl...) Show SMILES CC1CCCN1CCOc1ccc2CC3CCC(Cc2c1)C3NS(=O)(=O)c1ccc(Cl)s1 |TLB:20:19:21:16.15,11:12:21:16.15,THB:22:21:19.12.18.13:16.15| Show InChI InChI=1S/C24H31ClN2O3S2/c1-16-3-2-10-27(16)11-12-30-21-7-6-17-13-18-4-5-19(14-20(17)15-21)24(18)26-32(28,29)23-9-8-22(25)31-23/h6-9,15-16,18-19,24,26H,2-5,10-14H2,1H3	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	335	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Research Laboratories Curated by ChEMBL					Assay Description Inhibitory concentration against Gamma-secretase in whole cell inhibition assay using SH-SY5Y cells				Bioorg Med Chem Lett 15: 373-8 (2004) Article DOI: 10.1016/j.bmcl.2004.10.062 BindingDB Entry DOI: 10.7270/Q2445KZQ
					More data for this Ligand-Target Pair
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2 (Homo sapiens (Human))	BDBM50157970 ((13-Benzenesulfonylamino-tricyclo[8.2.1.0*3,8*]tri...) Show SMILES Clc1cccc(COC(=O)Nc2ccc3CC4CCC(Cc3c2)C4NS(=O)(=O)c2ccccc2)c1 |TLB:13:14:23:17.18,22:21:23:17.18,THB:24:23:21.14.20.15:17.18| Show InChI InChI=1S/C27H27ClN2O4S/c28-23-6-4-5-18(13-23)17-34-27(31)29-24-12-11-19-14-20-9-10-21(15-22(19)16-24)26(20)30-35(32,33)25-7-2-1-3-8-25/h1-8,11-13,16,20-21,26,30H,9-10,14-15,17H2,(H,29,31)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	412	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Research Laboratories Curated by ChEMBL					Assay Description Inhibitory concentration against Gamma-secretase in whole cell inhibition assay using SH-SY5Y cells				Bioorg Med Chem Lett 15: 373-8 (2004) Article DOI: 10.1016/j.bmcl.2004.10.062 BindingDB Entry DOI: 10.7270/Q2445KZQ
					More data for this Ligand-Target Pair
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2 (Homo sapiens (Human))	BDBM50157979 (4-Chloro-N-tricyclo[8.2.1.0*3,8*]trideca-3(8),4,6-...) Show SMILES Clc1ccc(cc1)S(=O)(=O)NC1C2CCC1Cc1ccccc1C2 |THB:10:11:23.16.17.22:13.14,18:17:11:13.14,21:22:11:13.14| Show InChI InChI=1S/C19H20ClNO2S/c20-17-7-9-18(10-8-17)24(22,23)21-19-15-5-6-16(19)12-14-4-2-1-3-13(14)11-15/h1-4,7-10,15-16,19,21H,5-6,11-12H2	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	467	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Research Laboratories Curated by ChEMBL					Assay Description Inhibitory concentration against Gamma-secretase in whole cell inhibition assay using SH-SY5Y cells				Bioorg Med Chem Lett 15: 373-8 (2004) Article DOI: 10.1016/j.bmcl.2004.10.062 BindingDB Entry DOI: 10.7270/Q2445KZQ
					More data for this Ligand-Target Pair
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2 (Homo sapiens (Human))	BDBM50158006 (5-Chloro-thiophene-2-sulfonic acid (5-methoxy-tric...) Show SMILES COc1ccc2CC3CCC(Cc2c1)C3NS(=O)(=O)c1ccc(Cl)s1 |TLB:13:12:14:8.9,4:5:14:8.9,THB:15:14:12.5.11.6:8.9| Show InChI InChI=1S/C18H20ClNO3S2/c1-23-15-5-4-11-8-12-2-3-13(9-14(11)10-15)18(12)20-25(21,22)17-7-6-16(19)24-17/h4-7,10,12-13,18,20H,2-3,8-9H2,1H3	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	490	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Research Laboratories Curated by ChEMBL					Assay Description Inhibitory concentration against Gamma-secretase in whole cell inhibition assay using SH-SY5Y cells				Bioorg Med Chem Lett 15: 373-8 (2004) Article DOI: 10.1016/j.bmcl.2004.10.062 BindingDB Entry DOI: 10.7270/Q2445KZQ
					More data for this Ligand-Target Pair
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2 (Homo sapiens (Human))	BDBM50158014 (5-Methyl-hexanoic acid (13-benzenesulfonylamino-tr...) Show SMILES CC(C)CCCC(=O)Nc1ccc2CC3CCC(Cc2c1)C3NS(=O)(=O)c1ccccc1 |TLB:11:12:21:16.15,20:19:21:16.15,THB:22:21:19.12.18.13:16.15| Show InChI InChI=1S/C26H34N2O3S/c1-18(2)7-6-10-25(29)27-23-14-13-19-15-20-11-12-21(16-22(19)17-23)26(20)28-32(30,31)24-8-4-3-5-9-24/h3-5,8-9,13-14,17-18,20-21,26,28H,6-7,10-12,15-16H2,1-2H3,(H,27,29)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	535	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Research Laboratories Curated by ChEMBL					Assay Description Inhibitory concentration against Gamma-secretase in whole cell inhibition assay using SH-SY5Y cells				Bioorg Med Chem Lett 15: 373-8 (2004) Article DOI: 10.1016/j.bmcl.2004.10.062 BindingDB Entry DOI: 10.7270/Q2445KZQ
					More data for this Ligand-Target Pair
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2 (Homo sapiens (Human))	BDBM50157997 (Butane-1-sulfonic acid tricyclo[8.2.1.0*3,8*]tride...) Show SMILES CCCCS(=O)(=O)NC1C2CCC1Cc1ccccc1C2 |THB:7:8:20.13.14.19:10.11,15:14:8:10.11,18:19:8:10.11| Show InChI InChI=1S/C17H25NO2S/c1-2-3-10-21(19,20)18-17-15-8-9-16(17)12-14-7-5-4-6-13(14)11-15/h4-7,15-18H,2-3,8-12H2,1H3	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	610	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Research Laboratories Curated by ChEMBL					Assay Description Inhibitory concentration against Gamma-secretase in whole cell inhibition assay using SH-SY5Y cells				Bioorg Med Chem Lett 15: 373-8 (2004) Article DOI: 10.1016/j.bmcl.2004.10.062 BindingDB Entry DOI: 10.7270/Q2445KZQ
					More data for this Ligand-Target Pair
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2 (Homo sapiens (Human))	BDBM50157989 (5-Chloro-thiophene-2-sulfonic acid {5-[2-(4-hydrox...) Show SMILES OC1CCN(CCOc2ccc3CC4CCC(Cc3c2)C4NS(=O)(=O)c2ccc(Cl)s2)CC1 |TLB:19:18:20:15.14,10:11:20:15.14,THB:21:20:18.11.17.12:15.14| Show InChI InChI=1S/C24H31ClN2O4S2/c25-22-5-6-23(32-22)33(29,30)26-24-17-1-2-18(24)14-19-15-21(4-3-16(19)13-17)31-12-11-27-9-7-20(28)8-10-27/h3-6,15,17-18,20,24,26,28H,1-2,7-14H2	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	623	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Research Laboratories Curated by ChEMBL					Assay Description Inhibitory concentration against Gamma-secretase in whole cell inhibition assay using SH-SY5Y cells				Bioorg Med Chem Lett 15: 373-8 (2004) Article DOI: 10.1016/j.bmcl.2004.10.062 BindingDB Entry DOI: 10.7270/Q2445KZQ
					More data for this Ligand-Target Pair
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2 (Homo sapiens (Human))	BDBM50157999 (4-Methyl-N-tricyclo[8.2.1.0*3,8*]trideca-3(8),4,6-...) Show SMILES Cc1ccc(cc1)S(=O)(=O)NC1C2CCC1Cc1ccccc1C2 |THB:10:11:23.16.17.22:13.14,18:17:11:13.14,21:22:11:13.14| Show InChI InChI=1S/C20H23NO2S/c1-14-6-10-19(11-7-14)24(22,23)21-20-17-8-9-18(20)13-16-5-3-2-4-15(16)12-17/h2-7,10-11,17-18,20-21H,8-9,12-13H2,1H3	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	651	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Research Laboratories Curated by ChEMBL					Assay Description Inhibitory concentration against Gamma-secretase in whole cell inhibition assay using SH-SY5Y cells				Bioorg Med Chem Lett 15: 373-8 (2004) Article DOI: 10.1016/j.bmcl.2004.10.062 BindingDB Entry DOI: 10.7270/Q2445KZQ
					More data for this Ligand-Target Pair
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2 (Homo sapiens (Human))	BDBM50157986 (CHEMBL360239 | Propane-1-sulfonic acid tricyclo[8....) Show SMILES CCCS(=O)(=O)NC1C2CCC1Cc1ccccc1C2 |THB:6:7:19.12.13.18:9.10,14:13:7:9.10,17:18:7:9.10| Show InChI InChI=1S/C16H23NO2S/c1-2-9-20(18,19)17-16-14-7-8-15(16)11-13-6-4-3-5-12(13)10-14/h3-6,14-17H,2,7-11H2,1H3	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	721	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Research Laboratories Curated by ChEMBL					Assay Description Inhibitory concentration against Gamma-secretase in whole cell inhibition assay using SH-SY5Y cells				Bioorg Med Chem Lett 15: 373-8 (2004) Article DOI: 10.1016/j.bmcl.2004.10.062 BindingDB Entry DOI: 10.7270/Q2445KZQ
					More data for this Ligand-Target Pair
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2 (Homo sapiens (Human))	BDBM50157987 (CHEMBL181152 | N-(13-Benzenesulfonylamino-tricyclo...) Show SMILES O=C(Nc1ccc2CC3CCC(Cc2c1)C3NS(=O)(=O)c1ccccc1)c1ccncc1 |TLB:5:6:15:10.9,14:13:15:10.9,THB:16:15:13.6.12.7:10.9| Show InChI InChI=1S/C25H25N3O3S/c29-25(17-10-12-26-13-11-17)27-22-9-8-18-14-19-6-7-20(15-21(18)16-22)24(19)28-32(30,31)23-4-2-1-3-5-23/h1-5,8-13,16,19-20,24,28H,6-7,14-15H2,(H,27,29)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Research Laboratories Curated by ChEMBL					Assay Description Inhibitory concentration against Gamma-secretase in whole cell inhibition assay using SH-SY5Y cells				Bioorg Med Chem Lett 15: 373-8 (2004) Article DOI: 10.1016/j.bmcl.2004.10.062 BindingDB Entry DOI: 10.7270/Q2445KZQ
					More data for this Ligand-Target Pair
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2 (Homo sapiens (Human))	BDBM50157985 (4-tert-Butyl-N-tricyclo[8.2.1.0*3,8*]trideca-3(8),...) Show SMILES CC(C)(C)c1ccc(cc1)S(=O)(=O)NC1C2CCC1Cc1ccccc1C2 |THB:13:14:26.19.20.25:16.17,21:20:14:16.17,24:25:14:16.17| Show InChI InChI=1S/C23H29NO2S/c1-23(2,3)20-10-12-21(13-11-20)27(25,26)24-22-18-8-9-19(22)15-17-7-5-4-6-16(17)14-18/h4-7,10-13,18-19,22,24H,8-9,14-15H2,1-3H3	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Research Laboratories Curated by ChEMBL					Assay Description Inhibitory concentration against Gamma-secretase in whole cell inhibition assay using SH-SY5Y cells				Bioorg Med Chem Lett 15: 373-8 (2004) Article DOI: 10.1016/j.bmcl.2004.10.062 BindingDB Entry DOI: 10.7270/Q2445KZQ
					More data for this Ligand-Target Pair
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2 (Homo sapiens (Human))	BDBM50158011 (CHEMBL183165 | N-(13-Benzenesulfonylamino-tricyclo...) Show SMILES CC(=O)Nc1ccc2CC3CCC(Cc2c1)C3NS(=O)(=O)c1ccccc1 |TLB:6:7:16:11.10,15:14:16:11.10,THB:17:16:14.7.13.8:11.10| Show InChI InChI=1S/C21H24N2O3S/c1-14(24)22-19-10-9-15-11-16-7-8-17(12-18(15)13-19)21(16)23-27(25,26)20-5-3-2-4-6-20/h2-6,9-10,13,16-17,21,23H,7-8,11-12H2,1H3,(H,22,24)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Research Laboratories Curated by ChEMBL					Assay Description Inhibitory concentration against Gamma-secretase in whole cell inhibition assay using SH-SY5Y cells				Bioorg Med Chem Lett 15: 373-8 (2004) Article DOI: 10.1016/j.bmcl.2004.10.062 BindingDB Entry DOI: 10.7270/Q2445KZQ
					More data for this Ligand-Target Pair
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2 (Homo sapiens (Human))	BDBM50158001 (CHEMBL361113 | Ethanesulfonic acid tricyclo[8.2.1....) Show SMILES CCS(=O)(=O)NC1C2CCC1Cc1ccccc1C2 |THB:5:6:18.11.12.17:8.9,13:12:6:8.9,16:17:6:8.9| Show InChI InChI=1S/C15H21NO2S/c1-2-19(17,18)16-15-13-7-8-14(15)10-12-6-4-3-5-11(12)9-13/h3-6,13-16H,2,7-10H2,1H3	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Research Laboratories Curated by ChEMBL					Assay Description Inhibitory concentration against Gamma-secretase in whole cell inhibition assay using SH-SY5Y cells				Bioorg Med Chem Lett 15: 373-8 (2004) Article DOI: 10.1016/j.bmcl.2004.10.062 BindingDB Entry DOI: 10.7270/Q2445KZQ
					More data for this Ligand-Target Pair
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2 (Homo sapiens (Human))	BDBM50157996 (4-Ethyl-N-tricyclo[8.2.1.0*3,8*]trideca-3(8),4,6-t...) Show SMILES CCc1ccc(cc1)S(=O)(=O)NC1C2CCC1Cc1ccccc1C2 |THB:11:12:24.17.18.23:14.15,19:18:12:14.15,22:23:12:14.15| Show InChI InChI=1S/C21H25NO2S/c1-2-15-7-11-20(12-8-15)25(23,24)22-21-18-9-10-19(21)14-17-6-4-3-5-16(17)13-18/h3-8,11-12,18-19,21-22H,2,9-10,13-14H2,1H3	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Research Laboratories Curated by ChEMBL					Assay Description Inhibitory concentration against Gamma-secretase in whole cell inhibition assay using SH-SY5Y cells				Bioorg Med Chem Lett 15: 373-8 (2004) Article DOI: 10.1016/j.bmcl.2004.10.062 BindingDB Entry DOI: 10.7270/Q2445KZQ
					More data for this Ligand-Target Pair

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