Found 370 hits with Last Name = 'roeloffs' and Initial = 'r' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Gamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2
(Homo sapiens (Human)) | BDBM144227
(US8952008, 4)Show SMILES CCn1cnc2c(cnnc12)-c1ccc(F)c(c1)-c1ccc(cc1OC)S(=O)(=O)CC Show InChI InChI=1S/C22H21FN4O3S/c1-4-27-13-24-21-18(12-25-26-22(21)27)14-6-9-19(23)17(10-14)16-8-7-15(11-20(16)30-3)31(28,29)5-2/h6-13H,4-5H2,1-3H3 | UniProtKB/SwissProt
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| Article
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| 0.180 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Displacement of [3H]-flumazenil from human GABAA alpha1beta3gamma2 receptor expressed in HEK293 cell membranes measured after 2 hrs by liquid scintil... |
J Med Chem 62: 5773-5796 (2019)
Article DOI: 10.1021/acs.jmedchem.9b00322
BindingDB Entry DOI: 10.7270/Q2HQ437D |
More data for this
Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2
(Homo sapiens (Human)) | BDBM50512947
(CHEMBL4545044)Show SMILES CCn1cnc2c(cnnc12)-c1ccc(F)c(c1)-c1cc2CN(C)C(=O)c2cc1OC Show InChI InChI=1S/C23H20FN5O2/c1-4-29-12-25-21-18(10-26-27-22(21)29)13-5-6-19(24)16(7-13)17-8-14-11-28(2)23(30)15(14)9-20(17)31-3/h5-10,12H,4,11H2,1-3H3 | UniProtKB/SwissProt
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UniChem
| Article
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| 0.640 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Displacement of [3H]-flumazenil from human GABAA alpha1beta3gamma2 receptor expressed in HEK293 cell membranes measured after 2 hrs by liquid scintil... |
J Med Chem 62: 5773-5796 (2019)
Article DOI: 10.1021/acs.jmedchem.9b00322
BindingDB Entry DOI: 10.7270/Q2HQ437D |
More data for this
Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-3/beta-3/gamma-2
(Homo sapiens (Human)) | BDBM144227
(US8952008, 4)Show SMILES CCn1cnc2c(cnnc12)-c1ccc(F)c(c1)-c1ccc(cc1OC)S(=O)(=O)CC Show InChI InChI=1S/C22H21FN4O3S/c1-4-27-13-24-21-18(12-25-26-22(21)27)14-6-9-19(23)17(10-14)16-8-7-15(11-20(16)30-3)31(28,29)5-2/h6-13H,4-5H2,1-3H3 | PDB
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| 1.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Displacement of [3H]-flumazenil from human GABAA alpha3beta3gamma2 receptor expressed in HEK293 cell membranes measured after 2 hrs by liquid scintil... |
J Med Chem 62: 5773-5796 (2019)
Article DOI: 10.1021/acs.jmedchem.9b00322
BindingDB Entry DOI: 10.7270/Q2HQ437D |
More data for this
Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-3/beta-3/gamma-2
(Homo sapiens (Human)) | BDBM50512947
(CHEMBL4545044)Show SMILES CCn1cnc2c(cnnc12)-c1ccc(F)c(c1)-c1cc2CN(C)C(=O)c2cc1OC Show InChI InChI=1S/C23H20FN5O2/c1-4-29-12-25-21-18(10-26-27-22(21)29)13-5-6-19(24)16(7-13)17-8-14-11-28(2)23(30)15(14)9-20(17)31-3/h5-10,12H,4,11H2,1-3H3 | PDB
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| PC cid
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UniChem
| Article
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| 2.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Displacement of [3H]-flumazenil from human GABAA alpha3beta3gamma2 receptor expressed in HEK293 cell membranes measured after 2 hrs by liquid scintil... |
J Med Chem 62: 5773-5796 (2019)
Article DOI: 10.1021/acs.jmedchem.9b00322
BindingDB Entry DOI: 10.7270/Q2HQ437D |
More data for this
Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-5/beta-2/gamma-2
(Homo sapiens (Human)) | BDBM144227
(US8952008, 4)Show SMILES CCn1cnc2c(cnnc12)-c1ccc(F)c(c1)-c1ccc(cc1OC)S(=O)(=O)CC Show InChI InChI=1S/C22H21FN4O3S/c1-4-27-13-24-21-18(12-25-26-22(21)27)14-6-9-19(23)17(10-14)16-8-7-15(11-20(16)30-3)31(28,29)5-2/h6-13H,4-5H2,1-3H3 | PDB
KEGG
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| 18 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Displacement of [3H]-flumazenil from human GABAA alpha5beta2gamma2 receptor expressed in HEK293 cell membranes measured after 2 hrs by liquid scintil... |
J Med Chem 62: 5773-5796 (2019)
Article DOI: 10.1021/acs.jmedchem.9b00322
BindingDB Entry DOI: 10.7270/Q2HQ437D |
More data for this
Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-5/beta-2/gamma-2
(Homo sapiens (Human)) | BDBM50512947
(CHEMBL4545044)Show SMILES CCn1cnc2c(cnnc12)-c1ccc(F)c(c1)-c1cc2CN(C)C(=O)c2cc1OC Show InChI InChI=1S/C23H20FN5O2/c1-4-29-12-25-21-18(10-26-27-22(21)29)13-5-6-19(24)16(7-13)17-8-14-11-28(2)23(30)15(14)9-20(17)31-3/h5-10,12H,4,11H2,1-3H3 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
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| PC cid
PC sid
UniChem
| Article
PubMed
| 33 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Displacement of [3H]-flumazenil from human GABAA alpha5beta2gamma2 receptor expressed in HEK293 cell membranes measured after 2 hrs by liquid scintil... |
J Med Chem 62: 5773-5796 (2019)
Article DOI: 10.1021/acs.jmedchem.9b00322
BindingDB Entry DOI: 10.7270/Q2HQ437D |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 10 subunit alpha
(Homo sapiens (Human)) | BDBM50329223
(CHEMBL1270797 | N-(3,5-dimethylphenyl)-5-(4-(trifl...)Show SMILES Cc1cc(C)cc(NC(=O)c2ccc(o2)-c2ccc(OC(F)(F)F)cc2)c1 Show InChI InChI=1S/C20H16F3NO3/c1-12-9-13(2)11-15(10-12)24-19(25)18-8-7-17(26-18)14-3-5-16(6-4-14)27-20(21,22)23/h3-11H,1-2H3,(H,24,25) | PDB
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| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of human NaV1.8 by electrophysiology |
Bioorg Med Chem Lett 20: 6812-5 (2010)
Article DOI: 10.1016/j.bmcl.2010.08.121
BindingDB Entry DOI: 10.7270/Q2F76CS6 |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 10 subunit alpha
(Homo sapiens (Human)) | BDBM50329211
(5-(4-chlorophenyl)-N-(2-methylbenzyl)nicotinamide ...)Show InChI InChI=1S/C20H17ClN2O/c1-14-4-2-3-5-16(14)13-23-20(24)18-10-17(11-22-12-18)15-6-8-19(21)9-7-15/h2-12H,13H2,1H3,(H,23,24) | PDB
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| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of human NaV1.8 by electrophysiology |
Bioorg Med Chem Lett 20: 6812-5 (2010)
Article DOI: 10.1016/j.bmcl.2010.08.121
BindingDB Entry DOI: 10.7270/Q2F76CS6 |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 10 subunit alpha
(Homo sapiens (Human)) | BDBM50329203
(5-(4-chlorophenyl)-N-((2-(2,2,2-trifluoroethoxy)py...)Show SMILES FC(F)(F)COc1ncccc1CNC(=O)c1cncc(c1)-c1ccc(Cl)cc1 Show InChI InChI=1S/C20H15ClF3N3O2/c21-17-5-3-13(4-6-17)15-8-16(10-25-9-15)18(28)27-11-14-2-1-7-26-19(14)29-12-20(22,23)24/h1-10H,11-12H2,(H,27,28) | PDB
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| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of human NaV1.8 by electrophysiology |
Bioorg Med Chem Lett 20: 6812-5 (2010)
Article DOI: 10.1016/j.bmcl.2010.08.121
BindingDB Entry DOI: 10.7270/Q2F76CS6 |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 10 subunit alpha
(Homo sapiens (Human)) | BDBM50329210
(CHEMBL1269883 | N-(2-chlorobenzyl)-5-(4-chlorophen...)Show InChI InChI=1S/C19H14Cl2N2O/c20-17-7-5-13(6-8-17)15-9-16(11-22-10-15)19(24)23-12-14-3-1-2-4-18(14)21/h1-11H,12H2,(H,23,24) | PDB
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| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of human NaV1.8 by electrophysiology |
Bioorg Med Chem Lett 20: 6812-5 (2010)
Article DOI: 10.1016/j.bmcl.2010.08.121
BindingDB Entry DOI: 10.7270/Q2F76CS6 |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 10 subunit alpha
(Homo sapiens (Human)) | BDBM50329206
(5-(4-chlorophenyl)-N-((2-ethoxypyridin-3-yl)methyl...)Show InChI InChI=1S/C20H18ClN3O2/c1-2-26-20-15(4-3-9-23-20)13-24-19(25)17-10-16(11-22-12-17)14-5-7-18(21)8-6-14/h3-12H,2,13H2,1H3,(H,24,25) | PDB
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| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of human NaV1.8 by electrophysiology |
Bioorg Med Chem Lett 20: 6812-5 (2010)
Article DOI: 10.1016/j.bmcl.2010.08.121
BindingDB Entry DOI: 10.7270/Q2F76CS6 |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 10 subunit alpha
(Homo sapiens (Human)) | BDBM50329218
(CHEMBL1271105 | N-(3,5-dimethylphenyl)-5-(4-(trifl...)Show SMILES Cc1cc(C)cc(NC(=O)c2nsc(n2)-c2ccc(OC(F)(F)F)cc2)c1 Show InChI InChI=1S/C18H14F3N3O2S/c1-10-7-11(2)9-13(8-10)22-16(25)15-23-17(27-24-15)12-3-5-14(6-4-12)26-18(19,20)21/h3-9H,1-2H3,(H,22,25) | PDB
UniProtKB/SwissProt
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| CHEMBL
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UniChem
| Article
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| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of human NaV1.8 by electrophysiology |
Bioorg Med Chem Lett 20: 6812-5 (2010)
Article DOI: 10.1016/j.bmcl.2010.08.121
BindingDB Entry DOI: 10.7270/Q2F76CS6 |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 10 subunit alpha
(Rattus norvegicus (Rat)) | BDBM50329205
(5-(4-chlorophenyl)-N-((2-(piperidin-1-yl)pyridin-3...)Show SMILES Clc1ccc(cc1)-c1cncc(c1)C(=O)NCc1cccnc1N1CCCCC1 Show InChI InChI=1S/C23H23ClN4O/c24-21-8-6-17(7-9-21)19-13-20(15-25-14-19)23(29)27-16-18-5-4-10-26-22(18)28-11-2-1-3-12-28/h4-10,13-15H,1-3,11-12,16H2,(H,27,29) | PDB
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| Article
PubMed
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of tetrodotoxin-resistant NaV1.8 in rat DRG neuron by electrophysiology |
Bioorg Med Chem Lett 20: 6812-5 (2010)
Article DOI: 10.1016/j.bmcl.2010.08.121
BindingDB Entry DOI: 10.7270/Q2F76CS6 |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 10 subunit alpha
(Homo sapiens (Human)) | BDBM50212239
(5-(4-chlorophenyl)-N-(3,5-dimethoxyphenyl)furan-2-...)Show SMILES COc1cc(NC(=O)c2ccc(o2)-c2ccc(Cl)cc2)cc(OC)c1 Show InChI InChI=1S/C19H16ClNO4/c1-23-15-9-14(10-16(11-15)24-2)21-19(22)18-8-7-17(25-18)12-3-5-13(20)6-4-12/h3-11H,1-2H3,(H,21,22) | PDB
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| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of human Nav1.8 channel expressed in HEK293 cells at -40 mV by patch clamp method |
Proc Natl Acad Sci USA 104: 8520-5 (2007)
Article DOI: 10.1073/pnas.0611364104
BindingDB Entry DOI: 10.7270/Q2J10411 |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
Sodium channel protein type 10 subunit alpha
(Homo sapiens (Human)) | BDBM50212239
(5-(4-chlorophenyl)-N-(3,5-dimethoxyphenyl)furan-2-...)Show SMILES COc1cc(NC(=O)c2ccc(o2)-c2ccc(Cl)cc2)cc(OC)c1 Show InChI InChI=1S/C19H16ClNO4/c1-23-15-9-14(10-16(11-15)24-2)21-19(22)18-8-7-17(25-18)12-3-5-13(20)6-4-12/h3-11H,1-2H3,(H,21,22) | PDB
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| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of human Nav1.8 channel expressed in human HEK293 cells by patch clamp method |
Proc Natl Acad Sci USA 104: 8520-5 (2007)
Article DOI: 10.1073/pnas.0611364104
BindingDB Entry DOI: 10.7270/Q2J10411 |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Sodium channel protein type 10 subunit alpha
(Homo sapiens (Human)) | BDBM50212239
(5-(4-chlorophenyl)-N-(3,5-dimethoxyphenyl)furan-2-...)Show SMILES COc1cc(NC(=O)c2ccc(o2)-c2ccc(Cl)cc2)cc(OC)c1 Show InChI InChI=1S/C19H16ClNO4/c1-23-15-9-14(10-16(11-15)24-2)21-19(22)18-8-7-17(25-18)12-3-5-13(20)6-4-12/h3-11H,1-2H3,(H,21,22) | PDB
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| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant Nav 1.8 channel expressed in HEK293 cells |
J Med Chem 51: 407-16 (2008)
Article DOI: 10.1021/jm070637u
BindingDB Entry DOI: 10.7270/Q2KK9CN7 |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Sodium channel protein type 10 subunit alpha
(Homo sapiens (Human)) | BDBM50329209
(5-(4-chlorophenyl)-N-(2-(piperidin-1-yl)benzyl)nic...)Show SMILES Clc1ccc(cc1)-c1cncc(c1)C(=O)NCc1ccccc1N1CCCCC1 Show InChI InChI=1S/C24H24ClN3O/c25-22-10-8-18(9-11-22)20-14-21(16-26-15-20)24(29)27-17-19-6-2-3-7-23(19)28-12-4-1-5-13-28/h2-3,6-11,14-16H,1,4-5,12-13,17H2,(H,27,29) | PDB
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| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of human NaV1.8 by electrophysiology |
Bioorg Med Chem Lett 20: 6812-5 (2010)
Article DOI: 10.1016/j.bmcl.2010.08.121
BindingDB Entry DOI: 10.7270/Q2F76CS6 |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 10 subunit alpha
(Rattus norvegicus (Rat)) | BDBM50329211
(5-(4-chlorophenyl)-N-(2-methylbenzyl)nicotinamide ...)Show InChI InChI=1S/C20H17ClN2O/c1-14-4-2-3-5-16(14)13-23-20(24)18-10-17(11-22-12-18)15-6-8-19(21)9-7-15/h2-12H,13H2,1H3,(H,23,24) | PDB
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| n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of tetrodotoxin-resistant NaV1.8 in rat DRG neuron by electrophysiology |
Bioorg Med Chem Lett 20: 6812-5 (2010)
Article DOI: 10.1016/j.bmcl.2010.08.121
BindingDB Entry DOI: 10.7270/Q2F76CS6 |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 10 subunit alpha
(Homo sapiens (Human)) | BDBM50329213
(5-(4-chlorophenyl)-N-(3,5-dimethylphenyl)nicotinam...)Show SMILES Cc1cc(C)cc(NC(=O)c2cncc(c2)-c2ccc(Cl)cc2)c1 Show InChI InChI=1S/C20H17ClN2O/c1-13-7-14(2)9-19(8-13)23-20(24)17-10-16(11-22-12-17)15-3-5-18(21)6-4-15/h3-12H,1-2H3,(H,23,24) | PDB
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| n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of human NaV1.8 by electrophysiology |
Bioorg Med Chem Lett 20: 6812-5 (2010)
Article DOI: 10.1016/j.bmcl.2010.08.121
BindingDB Entry DOI: 10.7270/Q2F76CS6 |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 10 subunit alpha
(Homo sapiens (Human)) | BDBM50329208
(5-(4-chlorophenyl)-N-(2-morpholinobenzyl)nicotinam...)Show SMILES Clc1ccc(cc1)-c1cncc(c1)C(=O)NCc1ccccc1N1CCOCC1 Show InChI InChI=1S/C23H22ClN3O2/c24-21-7-5-17(6-8-21)19-13-20(15-25-14-19)23(28)26-16-18-3-1-2-4-22(18)27-9-11-29-12-10-27/h1-8,13-15H,9-12,16H2,(H,26,28) | PDB
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| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of human NaV1.8 by electrophysiology |
Bioorg Med Chem Lett 20: 6812-5 (2010)
Article DOI: 10.1016/j.bmcl.2010.08.121
BindingDB Entry DOI: 10.7270/Q2F76CS6 |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 10 subunit alpha
(Homo sapiens (Human)) | BDBM50329205
(5-(4-chlorophenyl)-N-((2-(piperidin-1-yl)pyridin-3...)Show SMILES Clc1ccc(cc1)-c1cncc(c1)C(=O)NCc1cccnc1N1CCCCC1 Show InChI InChI=1S/C23H23ClN4O/c24-21-8-6-17(7-9-21)19-13-20(15-25-14-19)23(29)27-16-18-5-4-10-26-22(18)28-11-2-1-3-12-28/h4-10,13-15H,1-3,11-12,16H2,(H,27,29) | PDB
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Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of human NaV1.8 by electrophysiology |
Bioorg Med Chem Lett 20: 6812-5 (2010)
Article DOI: 10.1016/j.bmcl.2010.08.121
BindingDB Entry DOI: 10.7270/Q2F76CS6 |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 10 subunit alpha
(Homo sapiens (Human)) | BDBM50329217
(CHEMBL1271106 | N-(2-Methylbenzyl)-6-(4-trifluorom...)Show SMILES Cc1cc(C)cc(NC(=O)c2cncc(n2)-c2ccc(OC(F)(F)F)cc2)c1 Show InChI InChI=1S/C20H16F3N3O2/c1-12-7-13(2)9-15(8-12)25-19(27)18-11-24-10-17(26-18)14-3-5-16(6-4-14)28-20(21,22)23/h3-11H,1-2H3,(H,25,27) | PDB
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Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of human NaV1.8 by electrophysiology |
Bioorg Med Chem Lett 20: 6812-5 (2010)
Article DOI: 10.1016/j.bmcl.2010.08.121
BindingDB Entry DOI: 10.7270/Q2F76CS6 |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 10 subunit alpha
(Homo sapiens (Human)) | BDBM50329212
(CHEMBL1271417 | N-benzyl-5-(4-chlorophenyl)nicotin...)Show InChI InChI=1S/C19H15ClN2O/c20-18-8-6-15(7-9-18)16-10-17(13-21-12-16)19(23)22-11-14-4-2-1-3-5-14/h1-10,12-13H,11H2,(H,22,23) | PDB
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Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of human NaV1.8 by electrophysiology |
Bioorg Med Chem Lett 20: 6812-5 (2010)
Article DOI: 10.1016/j.bmcl.2010.08.121
BindingDB Entry DOI: 10.7270/Q2F76CS6 |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 10 subunit alpha
(Homo sapiens (Human)) | BDBM50329202
(5-(4-cyanophenyl)-N-(3,5-dimethylphenyl)nicotinami...)Show SMILES Cc1cc(C)cc(NC(=O)c2cncc(c2)-c2ccc(cc2)C#N)c1 Show InChI InChI=1S/C21H17N3O/c1-14-7-15(2)9-20(8-14)24-21(25)19-10-18(12-23-13-19)17-5-3-16(11-22)4-6-17/h3-10,12-13H,1-2H3,(H,24,25) | PDB
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Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of human NaV1.8 by electrophysiology |
Bioorg Med Chem Lett 20: 6812-5 (2010)
Article DOI: 10.1016/j.bmcl.2010.08.121
BindingDB Entry DOI: 10.7270/Q2F76CS6 |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 10 subunit alpha
(Mus musculus) | BDBM50329205
(5-(4-chlorophenyl)-N-((2-(piperidin-1-yl)pyridin-3...)Show SMILES Clc1ccc(cc1)-c1cncc(c1)C(=O)NCc1cccnc1N1CCCCC1 Show InChI InChI=1S/C23H23ClN4O/c24-21-8-6-17(7-9-21)19-13-20(15-25-14-19)23(29)27-16-18-5-4-10-26-22(18)28-11-2-1-3-12-28/h4-10,13-15H,1-3,11-12,16H2,(H,27,29) | PDB
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Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of mouse NaV1.8 by electrophysiology |
Bioorg Med Chem Lett 20: 6812-5 (2010)
Article DOI: 10.1016/j.bmcl.2010.08.121
BindingDB Entry DOI: 10.7270/Q2F76CS6 |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 10 subunit alpha
(Homo sapiens (Human)) | BDBM50329215
(CHEMBL1271206 | N-(3,5-dimethylphenyl)-5-(4-(trifl...)Show SMILES Cc1cc(C)cc(NC(=O)c2cncc(c2)-c2ccc(OC(F)(F)F)cc2)c1 Show InChI InChI=1S/C21H17F3N2O2/c1-13-7-14(2)9-18(8-13)26-20(27)17-10-16(11-25-12-17)15-3-5-19(6-4-15)28-21(22,23)24/h3-12H,1-2H3,(H,26,27) | PDB
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Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of human NaV1.8 by electrophysiology |
Bioorg Med Chem Lett 20: 6812-5 (2010)
Article DOI: 10.1016/j.bmcl.2010.08.121
BindingDB Entry DOI: 10.7270/Q2F76CS6 |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 10 subunit alpha
(Rattus norvegicus (Rat)) | BDBM50329203
(5-(4-chlorophenyl)-N-((2-(2,2,2-trifluoroethoxy)py...)Show SMILES FC(F)(F)COc1ncccc1CNC(=O)c1cncc(c1)-c1ccc(Cl)cc1 Show InChI InChI=1S/C20H15ClF3N3O2/c21-17-5-3-13(4-6-17)15-8-16(10-25-9-15)18(28)27-11-14-2-1-7-26-19(14)29-12-20(22,23)24/h1-10H,11-12H2,(H,27,28) | PDB
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Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of tetrodotoxin-resistant NaV1.8 in rat DRG neuron by electrophysiology |
Bioorg Med Chem Lett 20: 6812-5 (2010)
Article DOI: 10.1016/j.bmcl.2010.08.121
BindingDB Entry DOI: 10.7270/Q2F76CS6 |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 10 subunit alpha
(Mus musculus) | BDBM50329209
(5-(4-chlorophenyl)-N-(2-(piperidin-1-yl)benzyl)nic...)Show SMILES Clc1ccc(cc1)-c1cncc(c1)C(=O)NCc1ccccc1N1CCCCC1 Show InChI InChI=1S/C24H24ClN3O/c25-22-10-8-18(9-11-22)20-14-21(16-26-15-20)24(29)27-17-19-6-2-3-7-23(19)28-12-4-1-5-13-28/h2-3,6-11,14-16H,1,4-5,12-13,17H2,(H,27,29) | PDB
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Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of mouse NaV1.8 by electrophysiology |
Bioorg Med Chem Lett 20: 6812-5 (2010)
Article DOI: 10.1016/j.bmcl.2010.08.121
BindingDB Entry DOI: 10.7270/Q2F76CS6 |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 10 subunit alpha
(Homo sapiens (Human)) | BDBM50270707
(CHEMBL486495 | [5-(4-tert-Butylphenyl)furan-2-yl]-...)Show SMILES CC(C)(C)c1ccc(cc1)-c1ccc(o1)C(=O)N1CCN(CC1)C1CCCCC1 Show InChI InChI=1S/C25H34N2O2/c1-25(2,3)20-11-9-19(10-12-20)22-13-14-23(29-22)24(28)27-17-15-26(16-18-27)21-7-5-4-6-8-21/h9-14,21H,4-8,15-18H2,1-3H3 | PDB
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Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant Nav1.8 channel expressed in HEK293 cells by whole cell voltage clamp technique |
Bioorg Med Chem 16: 6379-86 (2008)
Article DOI: 10.1016/j.bmc.2008.05.003
BindingDB Entry DOI: 10.7270/Q2VH5NNT |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 10 subunit alpha
(Mus musculus) | BDBM50231774
(5-(4-chlorophenyl)-N-cyano-N'-(3-methylphenyl)fura...)Show SMILES Cc1cccc(c1)N=C(NC#N)c1ccc(o1)-c1ccc(Cl)cc1 |w:7.7| Show InChI InChI=1S/C19H14ClN3O/c1-13-3-2-4-16(11-13)23-19(22-12-21)18-10-9-17(24-18)14-5-7-15(20)8-6-14/h2-11H,1H3,(H,22,23) | PDB
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Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of mouse recombinant Nav 1.8 channel expressed in HEK293 cells by isotopic efflux assay |
J Med Chem 51: 407-16 (2008)
Article DOI: 10.1021/jm070637u
BindingDB Entry DOI: 10.7270/Q2KK9CN7 |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 10 subunit alpha
(Mus musculus) | BDBM50329211
(5-(4-chlorophenyl)-N-(2-methylbenzyl)nicotinamide ...)Show InChI InChI=1S/C20H17ClN2O/c1-14-4-2-3-5-16(14)13-23-20(24)18-10-17(11-22-12-18)15-6-8-19(21)9-7-15/h2-12H,13H2,1H3,(H,23,24) | PDB
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Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of mouse NaV1.8 by electrophysiology |
Bioorg Med Chem Lett 20: 6812-5 (2010)
Article DOI: 10.1016/j.bmcl.2010.08.121
BindingDB Entry DOI: 10.7270/Q2F76CS6 |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 10 subunit alpha
(Mus musculus) | BDBM50329208
(5-(4-chlorophenyl)-N-(2-morpholinobenzyl)nicotinam...)Show SMILES Clc1ccc(cc1)-c1cncc(c1)C(=O)NCc1ccccc1N1CCOCC1 Show InChI InChI=1S/C23H22ClN3O2/c24-21-7-5-17(6-8-21)19-13-20(15-25-14-19)23(28)26-16-18-3-1-2-4-22(18)27-9-11-29-12-10-27/h1-8,13-15H,9-12,16H2,(H,26,28) | PDB
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Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of mouse NaV1.8 by electrophysiology |
Bioorg Med Chem Lett 20: 6812-5 (2010)
Article DOI: 10.1016/j.bmcl.2010.08.121
BindingDB Entry DOI: 10.7270/Q2F76CS6 |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 10 subunit alpha
(Rattus norvegicus (Rat)) | BDBM50329206
(5-(4-chlorophenyl)-N-((2-ethoxypyridin-3-yl)methyl...)Show InChI InChI=1S/C20H18ClN3O2/c1-2-26-20-15(4-3-9-23-20)13-24-19(25)17-10-16(11-22-12-17)14-5-7-18(21)8-6-14/h3-12H,2,13H2,1H3,(H,24,25) | PDB
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Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of tetrodotoxin-resistant NaV1.8 in rat DRG neuron by electrophysiology |
Bioorg Med Chem Lett 20: 6812-5 (2010)
Article DOI: 10.1016/j.bmcl.2010.08.121
BindingDB Entry DOI: 10.7270/Q2F76CS6 |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 10 subunit alpha
(Rattus norvegicus (Rat)) | BDBM50329217
(CHEMBL1271106 | N-(2-Methylbenzyl)-6-(4-trifluorom...)Show SMILES Cc1cc(C)cc(NC(=O)c2cncc(n2)-c2ccc(OC(F)(F)F)cc2)c1 Show InChI InChI=1S/C20H16F3N3O2/c1-12-7-13(2)9-15(8-12)25-19(27)18-11-24-10-17(26-18)14-3-5-16(6-4-14)28-20(21,22)23/h3-11H,1-2H3,(H,25,27) | PDB
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Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of tetrodotoxin-resistant NaV1.8 in rat DRG neuron by electrophysiology |
Bioorg Med Chem Lett 20: 6812-5 (2010)
Article DOI: 10.1016/j.bmcl.2010.08.121
BindingDB Entry DOI: 10.7270/Q2F76CS6 |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 10 subunit alpha
(Rattus norvegicus (Rat)) | BDBM50212239
(5-(4-chlorophenyl)-N-(3,5-dimethoxyphenyl)furan-2-...)Show SMILES COc1cc(NC(=O)c2ccc(o2)-c2ccc(Cl)cc2)cc(OC)c1 Show InChI InChI=1S/C19H16ClNO4/c1-23-15-9-14(10-16(11-15)24-2)21-19(22)18-8-7-17(25-18)12-3-5-13(20)6-4-12/h3-11H,1-2H3,(H,21,22) | PDB
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Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of recombinant rat Nav1.8 sodium channel assessed as blockade of TTXR current by patch clamp method |
Proc Natl Acad Sci USA 104: 8520-5 (2007)
Article DOI: 10.1073/pnas.0611364104
BindingDB Entry DOI: 10.7270/Q2J10411 |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 10 subunit alpha
(Rattus norvegicus (Rat)) | BDBM50329209
(5-(4-chlorophenyl)-N-(2-(piperidin-1-yl)benzyl)nic...)Show SMILES Clc1ccc(cc1)-c1cncc(c1)C(=O)NCc1ccccc1N1CCCCC1 Show InChI InChI=1S/C24H24ClN3O/c25-22-10-8-18(9-11-22)20-14-21(16-26-15-20)24(29)27-17-19-6-2-3-7-23(19)28-12-4-1-5-13-28/h2-3,6-11,14-16H,1,4-5,12-13,17H2,(H,27,29) | PDB
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Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of tetrodotoxin-resistant NaV1.8 in rat DRG neuron by electrophysiology |
Bioorg Med Chem Lett 20: 6812-5 (2010)
Article DOI: 10.1016/j.bmcl.2010.08.121
BindingDB Entry DOI: 10.7270/Q2F76CS6 |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 2 subunit alpha
(Homo sapiens (Human)) | BDBM50329209
(5-(4-chlorophenyl)-N-(2-(piperidin-1-yl)benzyl)nic...)Show SMILES Clc1ccc(cc1)-c1cncc(c1)C(=O)NCc1ccccc1N1CCCCC1 Show InChI InChI=1S/C24H24ClN3O/c25-22-10-8-18(9-11-22)20-14-21(16-26-15-20)24(29)27-17-19-6-2-3-7-23(19)28-12-4-1-5-13-28/h2-3,6-11,14-16H,1,4-5,12-13,17H2,(H,27,29) | PDB
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Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of human NaV1.2 by electrophysiology |
Bioorg Med Chem Lett 20: 6812-5 (2010)
Article DOI: 10.1016/j.bmcl.2010.08.121
BindingDB Entry DOI: 10.7270/Q2F76CS6 |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 10 subunit alpha
(Homo sapiens (Human)) | BDBM50329219
(CHEMBL1270999 | N-(3,5-dimethylphenyl)-2-(4-(trifl...)Show SMILES Cc1cc(C)cc(NC(=O)c2csc(n2)-c2ccc(OC(F)(F)F)cc2)c1 Show InChI InChI=1S/C19H15F3N2O2S/c1-11-7-12(2)9-14(8-11)23-17(25)16-10-27-18(24-16)13-3-5-15(6-4-13)26-19(20,21)22/h3-10H,1-2H3,(H,23,25) | PDB
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Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of human NaV1.8 by electrophysiology |
Bioorg Med Chem Lett 20: 6812-5 (2010)
Article DOI: 10.1016/j.bmcl.2010.08.121
BindingDB Entry DOI: 10.7270/Q2F76CS6 |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 10 subunit alpha
(Mus musculus) | BDBM50329217
(CHEMBL1271106 | N-(2-Methylbenzyl)-6-(4-trifluorom...)Show SMILES Cc1cc(C)cc(NC(=O)c2cncc(n2)-c2ccc(OC(F)(F)F)cc2)c1 Show InChI InChI=1S/C20H16F3N3O2/c1-12-7-13(2)9-15(8-12)25-19(27)18-11-24-10-17(26-18)14-3-5-16(6-4-14)28-20(21,22)23/h3-11H,1-2H3,(H,25,27) | PDB
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Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of mouse NaV1.8 by electrophysiology |
Bioorg Med Chem Lett 20: 6812-5 (2010)
Article DOI: 10.1016/j.bmcl.2010.08.121
BindingDB Entry DOI: 10.7270/Q2F76CS6 |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 10 subunit alpha
(Homo sapiens (Human)) | BDBM50329216
(CHEMBL1271205 | N-(3,5-dimethylphenyl)-6-(4-(trifl...)Show SMILES Cc1cc(C)cc(NC(=O)c2cccc(n2)-c2ccc(OC(F)(F)F)cc2)c1 Show InChI InChI=1S/C21H17F3N2O2/c1-13-10-14(2)12-16(11-13)25-20(27)19-5-3-4-18(26-19)15-6-8-17(9-7-15)28-21(22,23)24/h3-12H,1-2H3,(H,25,27) | PDB
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Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of human NaV1.8 by electrophysiology |
Bioorg Med Chem Lett 20: 6812-5 (2010)
Article DOI: 10.1016/j.bmcl.2010.08.121
BindingDB Entry DOI: 10.7270/Q2F76CS6 |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 10 subunit alpha
(Rattus norvegicus (Rat)) | BDBM50329210
(CHEMBL1269883 | N-(2-chlorobenzyl)-5-(4-chlorophen...)Show InChI InChI=1S/C19H14Cl2N2O/c20-17-7-5-13(6-8-17)15-9-16(11-22-10-15)19(24)23-12-14-3-1-2-4-18(14)21/h1-11H,12H2,(H,23,24) | PDB
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Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of tetrodotoxin-resistant NaV1.8 in rat DRG neuron by electrophysiology |
Bioorg Med Chem Lett 20: 6812-5 (2010)
Article DOI: 10.1016/j.bmcl.2010.08.121
BindingDB Entry DOI: 10.7270/Q2F76CS6 |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 2 subunit alpha
(Homo sapiens (Human)) | BDBM50329205
(5-(4-chlorophenyl)-N-((2-(piperidin-1-yl)pyridin-3...)Show SMILES Clc1ccc(cc1)-c1cncc(c1)C(=O)NCc1cccnc1N1CCCCC1 Show InChI InChI=1S/C23H23ClN4O/c24-21-8-6-17(7-9-21)19-13-20(15-25-14-19)23(29)27-16-18-5-4-10-26-22(18)28-11-2-1-3-12-28/h4-10,13-15H,1-3,11-12,16H2,(H,27,29) | PDB
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Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of human NaV1.2 by electrophysiology |
Bioorg Med Chem Lett 20: 6812-5 (2010)
Article DOI: 10.1016/j.bmcl.2010.08.121
BindingDB Entry DOI: 10.7270/Q2F76CS6 |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 10 subunit alpha
(Homo sapiens (Human)) | BDBM50231767
(5-(4-cyanophenyl)-N-(3-methylphenyl)furan-2-carbox...)Show InChI InChI=1S/C19H14N2O2/c1-13-3-2-4-16(11-13)21-19(22)18-10-9-17(23-18)15-7-5-14(12-20)6-8-15/h2-11H,1H3,(H,21,22) | PDB
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Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant Nav 1.8 channel expressed in HEK293 cells |
J Med Chem 51: 407-16 (2008)
Article DOI: 10.1021/jm070637u
BindingDB Entry DOI: 10.7270/Q2KK9CN7 |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 10 subunit alpha
(Homo sapiens (Human)) | BDBM50212239
(5-(4-chlorophenyl)-N-(3,5-dimethoxyphenyl)furan-2-...)Show SMILES COc1cc(NC(=O)c2ccc(o2)-c2ccc(Cl)cc2)cc(OC)c1 Show InChI InChI=1S/C19H16ClNO4/c1-23-15-9-14(10-16(11-15)24-2)21-19(22)18-8-7-17(25-18)12-3-5-13(20)6-4-12/h3-11H,1-2H3,(H,21,22) | PDB
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Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of human Nav1.8 channel expressed in HEK293 cells at -100 mV by patch clamp method |
Proc Natl Acad Sci USA 104: 8520-5 (2007)
Article DOI: 10.1073/pnas.0611364104
BindingDB Entry DOI: 10.7270/Q2J10411 |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Sodium channel protein type 10 subunit alpha
(Mus musculus) | BDBM50329210
(CHEMBL1269883 | N-(2-chlorobenzyl)-5-(4-chlorophen...)Show InChI InChI=1S/C19H14Cl2N2O/c20-17-7-5-13(6-8-17)15-9-16(11-22-10-15)19(24)23-12-14-3-1-2-4-18(14)21/h1-11H,12H2,(H,23,24) | PDB
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Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of mouse NaV1.8 by electrophysiology |
Bioorg Med Chem Lett 20: 6812-5 (2010)
Article DOI: 10.1016/j.bmcl.2010.08.121
BindingDB Entry DOI: 10.7270/Q2F76CS6 |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 10 subunit alpha
(Rattus norvegicus (Rat)) | BDBM50329212
(CHEMBL1271417 | N-benzyl-5-(4-chlorophenyl)nicotin...)Show InChI InChI=1S/C19H15ClN2O/c20-18-8-6-15(7-9-18)16-10-17(13-21-12-16)19(23)22-11-14-4-2-1-3-5-14/h1-10,12-13H,11H2,(H,22,23) | PDB
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Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of tetrodotoxin-resistant NaV1.8 in rat DRG neuron by electrophysiology |
Bioorg Med Chem Lett 20: 6812-5 (2010)
Article DOI: 10.1016/j.bmcl.2010.08.121
BindingDB Entry DOI: 10.7270/Q2F76CS6 |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 10 subunit alpha
(Mus musculus) | BDBM50329203
(5-(4-chlorophenyl)-N-((2-(2,2,2-trifluoroethoxy)py...)Show SMILES FC(F)(F)COc1ncccc1CNC(=O)c1cncc(c1)-c1ccc(Cl)cc1 Show InChI InChI=1S/C20H15ClF3N3O2/c21-17-5-3-13(4-6-17)15-8-16(10-25-9-15)18(28)27-11-14-2-1-7-26-19(14)29-12-20(22,23)24/h1-10H,11-12H2,(H,27,28) | PDB
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Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of mouse NaV1.8 by electrophysiology |
Bioorg Med Chem Lett 20: 6812-5 (2010)
Article DOI: 10.1016/j.bmcl.2010.08.121
BindingDB Entry DOI: 10.7270/Q2F76CS6 |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 10 subunit alpha
(Homo sapiens (Human)) | BDBM50329204
(5-(4-chlorophenyl)-N-((2-morpholinopyridin-3-yl)me...)Show SMILES Clc1ccc(cc1)-c1cncc(c1)C(=O)NCc1cccnc1N1CCOCC1 Show InChI InChI=1S/C22H21ClN4O2/c23-20-5-3-16(4-6-20)18-12-19(14-24-13-18)22(28)26-15-17-2-1-7-25-21(17)27-8-10-29-11-9-27/h1-7,12-14H,8-11,15H2,(H,26,28) | PDB
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Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of human NaV1.8 by electrophysiology |
Bioorg Med Chem Lett 20: 6812-5 (2010)
Article DOI: 10.1016/j.bmcl.2010.08.121
BindingDB Entry DOI: 10.7270/Q2F76CS6 |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 10 subunit alpha
(Rattus norvegicus (Rat)) | BDBM50329213
(5-(4-chlorophenyl)-N-(3,5-dimethylphenyl)nicotinam...)Show SMILES Cc1cc(C)cc(NC(=O)c2cncc(c2)-c2ccc(Cl)cc2)c1 Show InChI InChI=1S/C20H17ClN2O/c1-13-7-14(2)9-19(8-13)23-20(24)17-10-16(11-22-12-17)15-3-5-18(21)6-4-15/h3-12H,1-2H3,(H,23,24) | PDB
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Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of tetrodotoxin-resistant NaV1.8 in rat DRG neuron by electrophysiology |
Bioorg Med Chem Lett 20: 6812-5 (2010)
Article DOI: 10.1016/j.bmcl.2010.08.121
BindingDB Entry DOI: 10.7270/Q2F76CS6 |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 10 subunit alpha
(Mus musculus) | BDBM50329206
(5-(4-chlorophenyl)-N-((2-ethoxypyridin-3-yl)methyl...)Show InChI InChI=1S/C20H18ClN3O2/c1-2-26-20-15(4-3-9-23-20)13-24-19(25)17-10-16(11-22-12-17)14-5-7-18(21)8-6-14/h3-12H,2,13H2,1H3,(H,24,25) | PDB
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Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of mouse NaV1.8 by electrophysiology |
Bioorg Med Chem Lett 20: 6812-5 (2010)
Article DOI: 10.1016/j.bmcl.2010.08.121
BindingDB Entry DOI: 10.7270/Q2F76CS6 |
More data for this
Ligand-Target Pair | |
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